@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0694: (2016-04-24 )
MAEAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAAFSELGFAPHVIGATDKRDLSTTVMGQEVSLPVIISPTGVQAVDPGGEVAVARAAAARGTVMGLSSFASKPIEEVIAANPKTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWTFSHGRDWGSPKIPEEMNLKTILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGRRGEPGPPFFAAYGEWMATPPPTWEDIGWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAVSAAVGDQVEVLLDGGIRRGSDVVKAVALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDSALMGLGHASVHDLSPADILVPTGFIRDLGVPSRRDV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80...-.-.-..-.90........100.........110.......-120---....-.--...130.......140.......150.......160-.---....---....170-.......180.......190.......200.......210--........220-----.......230.......240.......250.......260.......270.......280.......290.......300---.........310.......320.......330.......340.......350.....--..360.......370.......380.......390....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
E
A
W
F
E
T
V
A
I
A
Q
Q
R
A
K
RRL
P
K
S
V
Y
S
S
L
I
A
ASEKG
I
T
V
A
D
N
V
A
A
F
S
ELGFAPHVIGATDKRDLS
T
T
VMGQEVS
L
P
V
I
ISPTG
V
Q
-
A
-V-DP-GG
E
V
A
V
A
RAAAA--R
G
T
V
M
G
L
S
S
F
A
SK
P
I
E
E
V
I
-AA----N
P
K
T
-
F
--
F
Q
V
YWQG
G
R
D
A
L
A
E
R
V
E
R
A
R
QAG
A
V
G
L
V
V
TT
D
W
T
---F---SHGR---DWGSPKI-PEEM
N
L
K
T
I
L
R
LS
P
E
AITR
P
R
W
L
W
K
F
A
K
TLRPPDLRVPN---QGRRGEPGP
P
F
-----
F
A
A
YGEWMATPPP
T
W
E
D
I
G
W
L
R
E
LWG
G
P
F
M
L
K
G
V
M
R
V
D
D
A
K
R
A
V
D
AGV
S
A
I
S
VSNHGGNNLDGTP
A
S
I
R
AL
P
A
V
S
A
AV-----G
D
Q
V
E
V
L
LDGGIRR
G
S
D
V
V
K
A
V
A
LG
A
R
A
V
M
IG
R
A
Y
L
W
G
LAANGQA
G
V
E
N
V
L
D
I
L
R
G
G
--
I
D
S
A
L
M
GLGHASVHDLSPA
D
I
L
VPT
G
F
I
R
DLGVPSRRDV
121
HHSearch
95.82
36%
-93
- C1 -
1GOX
2
GOX_SPIOL
A:
[2-359]
----
E
I
T
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
-
K
M
A
-
H
P
-
E
G
E
Y
A
T
A
R
A
A
S
A
--
A
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
-
S
T
G
---
P
G
I
R
-
F
--
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
RLG
R
---
R
E
A
D
---
I
K
N
R
F
V
L
-
P
P
F
L
T
L
K
N
F
E
G
I
----------------
D
L
G
---------------------------
L
S
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
-----
Q
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
--
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
S
H
I
A
A
D
W
D
-------------
14
PsiBlast_PDB
93.28
32%
-87
- C1 -
2A7P
3
GOX_SPIOL (first)
A:
[4-350]
---
N
L
F
-
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
-
L
-
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
----
D
G
D
L
-
W
--
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
---
V
---
N
G
Y
R
-------------
E
R
D
L
H
N
R
F
K
I
P
P
---------
F
L
T
L
K
N
F
E
G
I
D
L
--------
G
K
M
D
K
A
N
L
E
M
-----
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
--
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
---------------------
4
PsiBlast_PDB
93.05
38%
-86
- C1 -
2RDW
2
HAOX1_HUMAN
A:
[29-354]
------------
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
-
R
-
M
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
-
E
A
----
G
P
E
A
-
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
---
Y
---
L
G
N
R
---------------------------
L
D
D
V
R
N
R
F
K
L
-----
P
P
Q
L
R
M
K
N
FET
S
T
L
S
F
S
P
E
E
N
F
GDDS
G
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
-----
E
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
-------------------------------------------
1
PsiBlast_PDB
92.73
38%
-90
- C1 -
2W0U
2
HAOX1_HUMAN
A:
[12-356]
------------
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
-
R
-
M
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
-
E
A
----
G
P
E
A
-
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
---
Y
---
L
G
N
R
L
D
D
V
R
N
R
F
K
L
-
P
------------------------------------------------
G
--------
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
-----
E
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
------------------------
15
PsiBlast_PDB
92.61
32%
-87
- C1 -
2A85
3
GOX_SPIOL
A:
[4-350]
---
N
L
F
-
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
-
L
-
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
----
D
G
D
L
-
W
--
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
---
V
---
N
G
Y
R
-------------
E
R
D
L
H
N
R
F
K
I
P
P
---------
F
L
T
L
K
N
F
E
G
I
D
L
--------
G
K
M
D
K
A
N
L
E
M
-----
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
--
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
---------------------
119
HHSearch
92.56
34%
-87
- C1 -
1P4C
3
GOX_SPIOL
A:
[4-356]
----
N
L
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
-
G
A
L
-
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
-
R
Q
C
---
D
G
D
L
-
W
--
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
VNG
Y
---
R
E
R
D
---
L
H
N
R
F
K
I
-
P
P
F
L
T
L
K
N
F
E
G
I
D
L
G
---------
K
M
D
K
A
N
L
E
-----------------
M
Q
A
A
-----
L
---
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
-------
G
K
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
--
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
Q
N
E
---------------
16
PsiBlast_PDB
92.50
32%
-85
- C1 -
3GIY
2
MDLB_PSEPU
A:
[4-350]
---
N
L
F
-
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
-
L
-
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
----
D
G
D
L
-
W
--
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
---
V
---
N
G
Y
R
-------------
E
R
D
L
H
N
R
F
K
I
P
P
---------
F
L
T
L
K
N
F
E
G
I
D
L
--------
G
K
M
D
K
A
N
L
E
M
-----
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
--
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
---------------------
3
PsiBlast_PDB
92.44
38%
-87
- C1 -
2RDU
2
HAOX1_HUMAN
A:
[29-354]
------------
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
-
R
-
M
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
-
E
A
----
G
P
E
A
-
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
---
Y
---
L
G
N
R
---------------------------
L
D
D
V
R
N
R
F
K
L
-----
P
P
Q
L
R
M
K
N
FET
S
T
L
S
F
S
P
E
E
N
F
GDDS
G
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
-----
E
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
-------------------------------------------
21
PsiBlast_CBE
91.91
38%
-89
- C1 -
2W0U
2
HAOX1_HUMAN
D:
[12-356]
------------
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
-
R
-
M
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
-
E
A
----
G
P
E
A
-
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
---
Y
---
L
G
N
R
L
D
D
V
R
N
R
F
K
L
--------------------------------------------------
G
--------
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
-----
E
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
------------------------
12
PsiBlast_PDB
91.77
32%
-87
- C1 -
1P5B
3
GOX_SPIOL (first)
A:
[4-350]
---
N
L
F
-
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
-
L
-
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
----
D
G
D
L
-
W
--
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
---
V
---
N
G
Y
R
-------------
E
R
D
L
H
N
R
F
K
I
P
P
---------
F
L
T
L
K
N
F
E
G
I
D
L
--------
G
K
M
D
K
A
N
L
E
M
-----
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
--
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
---------------------
11
PsiBlast_PDB
91.74
32%
-85
- C1 -
1P4C
3
GOX_SPIOL
A:
[4-350]
---
N
L
F
-
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
-
L
-
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
----
D
G
D
L
-
W
--
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
---
V
---
N
G
Y
R
-------------
E
R
D
L
H
N
R
F
K
I
P
P
---------
F
L
T
L
K
N
F
E
G
I
D
L
--------
G
K
M
D
K
A
N
L
E
M
-----
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
--
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
---------------------
23
PsiBlast_CBE
91.68
38%
-90
- C1 -
2W0U
2
HAOX1_HUMAN
B:
[12-356]
------------
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
-
R
-
M
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
-
E
A
----
G
P
E
A
-
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
---
Y
---
L
G
N
R
L
D
D
V
R
N
R
F
K
L
--------------------------------------------------
G
--------
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
-----
E
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
------------------------
13
PsiBlast_PDB
91.35
32%
-85
- C1 -
2A7N
2
GOX_SPIOL
A:
[4-350]
---
N
L
F
-
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
-
L
-
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
----
D
G
D
L
-
W
--
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
---
V
---
N
G
Y
R
-------------
E
R
D
L
H
N
R
F
K
I
P
P
---------
F
L
T
L
K
N
F
E
G
I
D
L
--------
G
K
M
D
K
A
N
L
E
M
-----
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
--
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
---------------------
22
PsiBlast_CBE
91.33
38%
-90
- C1 -
2W0U
2
HAOX1_HUMAN
C:
[12-356]
------------
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
-
R
-
M
A
H
V
-
D
G
E
L
A
T
V
R
A
C
Q
S
--
L
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
-
E
A
----
G
P
E
A
-
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
---
Y
---
L
G
N
R
L
D
D
V
R
N
R
F
----------------------------------------------------
G
--------
L
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
-----
E
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
------------------------
8
PsiBlast_PDB
90.86
35%
-87
- C1 -
1GOX
1
GOX_SPIOL
A:
[13-354]
---------------
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
-
K
-
M
A
H
P
-
E
G
E
Y
A
T
A
R
A
A
S
A
--
A
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
-
S
T
----
G
P
G
I
R
F
--
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
-------------------
T
P
R
L
G
R
R
E
A
D
I
K
N
R
F
V
L
P
P
---------
F
L
T
L
K
N
F
E
G
I
D
L
--------
G
--------------
L
S
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
-----
Q
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
--
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
S
H
I
------------------
10
PsiBlast_PDB
90.84
32%
-87
- C1 -
1HUV
3
GOX_SPIOL (first)
A:
[4-350]
---
N
L
F
-
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
-
L
-
W
P
-
K
G
D
L
A
L
A
R
A
A
T
K
--
A
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
----
D
G
D
L
-
W
--
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
---
V
---
N
G
Y
R
-------------
E
R
D
L
H
N
R
F
K
I
P
P
---------
F
L
T
L
K
N
F
E
G
I
D
L
--------
G
K
M
D
----
E
M
-----
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
-----
G
K
--
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
--
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
---------------------
7
PsiBlast_PDB
90.55
35%
-88
- C1 -
1AL8
2
GOX_SPIOL
A:
[13-354]
---------------
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
-
K
-
M
A
H
P
-
E
G
E
Y
A
T
A
R
A
A
S
A
--
A
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
-
S
T
----
G
P
G
I
R
F
--
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
-------------------
T
P
R
L
------
I
K
N
R
F
V
L
P
P
---------
F
L
T
L
K
N
F
E
G
I
D
L
--------
G
--------------
L
S
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
-----
Q
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
--
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
S
H
I
------------------
123
HHSearch
90.48
29%
-92
- C1 -
1KBI
6
CYB2_YEAST
A:
[121-491]
----
N
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
-
K
L
G
-
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
GV
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
-
E
A
APSD
K
Q
I
Q
-
W
--
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
---
S
LGQ
R
E
K
D
---
M
K
L
K
F
S
N
-
T
-----------------------------
K
K
T
N
V
E
---------
E
S
Q
G
A
S
R
A
-----
L
----
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
RNL
K
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
--
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
D
L
S
T
L
K
A
R
T
V
G
V
P
-----
6
PsiBlast_PDB
89.35
35%
-86
- C1 -
1AL7
2
GOX_SPIOL
A:
[13-354]
---------------
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
-
K
-
M
A
H
P
-
E
G
E
Y
A
T
A
R
A
A
S
A
--
A
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
-
S
T
----
G
P
G
I
R
F
--
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
-------------------
T
P
R
L
G
R
R
E
A
D
I
K
N
R
F
V
L
P
P
---------
F
L
T
L
K
N
F
E
G
I
D
L
--------
G
--------------
L
S
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
-----
Q
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
--
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
S
H
I
------------------
122
HHSearch
89.31
35%
-94
* C1 *
3SGZ
2
HAOX2_RAT
A:
[2-349]
-----
L
V
C
L
A
D
F
K
A
H
A
Q
K
Q
L
S
K
T
S
W
D
F
I
E
G
E
A
D
D
G
I
T
Y
S
E
N
I
A
A
F
K
R
I
R
L
R
P
R
Y
L
R
D
M
S
K
V
D
T
R
T
T
I
Q
G
Q
E
I
S
A
P
I
C
I
S
P
T
A
F
H
-
S
I
A
-
W
P
-
D
G
E
K
S
T
A
R
A
A
Q
E
--
A
N
I
C
Y
V
I
S
S
Y
A
S
Y
S
L
E
D
I
V
-
A
A
A
P--
E
G
F
R
-
W
--
F
Q
L
Y
M
K
S
D
W
D
F
N
K
Q
M
V
Q
R
A
E
A
L
G
F
K
A
L
V
I
T
I
D
T
P
---
V
LGN
R
R
R
D
---
K
R
N
Q
L
N
L
-
E
A
N
I
L
-
K
A
--------------------
A
L
-----------------------------------
F
P
K
A
S
F
C
W
N
D
L
S
L
L
Q
S
I
T
R
L
P
I
I
L
K
G
I
L
T
K
E
D
A
E
L
A
M
K
H
N
V
Q
G
I
V
V
S
N
H
G
G
R
Q
L
D
E
V
S
A
S
I
D
A
L
R
E
V
V
A
A
V
-----
K
G
K
I
E
V
Y
M
D
G
G
V
R
T
G
T
D
V
L
K
A
L
A
L
G
A
R
C
I
F
L
G
R
P
I
L
W
G
L
A
C
K
G
E
D
G
V
K
E
V
L
D
I
L
T
A
E
--
L
H
R
C
M
T
L
S
G
C
Q
S
V
A
E
I
S
P
D
L
I
Q
F
----------------