@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0730: (2016-04-25 )
MHGARTGVSFYAYAMTDHDQTAARREIADALLAALERRHEVADAIVEAANKAAAVEAIVNLLGTSHLAAEAVMSMSFDQLTQDARTKIIAELDDLNKQLSFTVKERPASSGEGLELRPFSPDEDRDIFARRTEEMGAAGDGSGGPAGSVDDEIRAAQKRVDDEEAAWFVAVDSGVKVGMVFGELVHGEVDVRIWIHPDHRKKGYGTAALRKSRSEMAWAFPAVPMVARAPAAQPAQPGSAGR
Atome Classification :
(20 SA)
-------------------------------------.........10........20-------.........30........40..-----...-----...50........60---------------------------------.........70........80........90........100-----.......110.......120.......130.-...---------------------------------------.--..140.......150.......-160--.-......-..170-.......180..---.---------...----.190.......200.......210.......--.--220..------.....230.......240--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------MHGARTG
V
S
F
Y
A
Y
A
MTDH
D
Q
--------
T
A
A
R
R
E
I
A
D
A
L
L
A
A
L
E
R
R
H
E
V
A
D
-----
A
I
V
-----
E
A
A
N
K
A
A
A
V
E
A
I
V
N
----------------------------------
L
LGT
S
H
L
A
A
E
A
V
M
S
M
S
F
D
Q
L
T
Q
D
A
R
T
K
I
I
A
E
L
D
D
L
N
K
Q
L
S
F
T
-----
V
KERPASSGE
G
L
E
LRPFSPDE
D
R
D
I
F
A
R
R
T
E
-
E
MG---------------------------------------A--AGDGSGGPAGS
V
D
D
E
I
R
A
A
Q
KR-V----D-DEE
A
A
W
-
F
V
A
VD-SGV
K
V
G
M
V
F
G
E
L
---V---------HG
E
----
V
D
V
R
I
W
IHPDHRKKGY
G
T
A
A
L
R
K-SRSE
M
A
W--A--FPAVP------MVARAPAAQPAQPGSAGR--------------
8
HHSearch
75.64
24%
-76
- C2 -
4ELY
2
GYRA_ECOLI
A:
[25-147]
--------------------------------------------------
T
I
F
E
L
R
K
--------
A
R
D
R
A
H
I
L
E
A
L
A
V
A
L
A
N
I
D
P
I
I
E
-----
L
I
R
-----
H
A
P
T
P
A
E
A
K
T
A
L
V
A
N
P
W
Q
L
G
N
V
A
A
M
L
E
RAGDDAARPEWLEPEFGVRDG
L
Y
Y
L
T
E
Q
Q
A
Q
A
I
L
D
L
R
L
Q
K
L
T
G
L
E
H
E
K
L
L
D
E
Y
K
E
L
L
D
Q
I
A
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
73.73
26%
-83
- C2 -
2XCS
-
GYRA_STAAN (first)
B:
[568-657]
--------------------------------------------------
T
Q
Y
N
L
R
K
--------
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
-----
T
I
R
-----
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
----------------------------------
R
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
-----
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
73.02
24%
-80
- C2 -
4CKK
-
?
A:
[367-489]
---------------------------------------------------
I
F
E
L
R
K
--------
A
R
D
R
A
H
I
L
E
A
L
A
V
A
L
A
N
I
D
P
I
I
E
-----
L
I
R
-----
H
A
P
T
P
A
E
A
K
T
A
L
V
A
N
P
W
Q
LGNV
A
A
M
L
E
RDDAARPEWLEPEFGVRDG--
L
Y
Y
L
T
E
Q
Q
A
Q
A
I
L
D
L
R
L
Q
K
L
T
G
L
E
H
E
K
L
L
D
E
Y
K
E
L
L
D
Q
I
A
E
L
-----
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
71.60
21%
-93
- C2 -
3ILW
-
GYRA_MYCTU
A:
[347-436]
--------------------------------------------------
T
T
Y
R
L
R
K
--------
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
-----
L
I
R
-----
A
S
E
T
V
D
I
A
R
A
G
L
I
E
----------------------------------
L
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
-----
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
70.97
15%
-29
- C1 -
1E19
1
CPKA_PYRFU
A:
[2-314]
---------------------------------------
G
K
R
V
V
I
A
L
G
G
N
A
L
Q
Q
R
G
Q
--------
K
G
S
Y
E
E
M
M
D
N
V
R
K
T
A
R
Q
I
A
E
I
I
A
R
GYE
V
V
I
T
H
G
N
G
P
Q
V
G
S
L
L
L
H
M
D
A
G
Q
A
----------------------------------
T
Y
G
I
P
A
Q
P
M
D
V
A
G
A
M
S
Q
G
W
I
G
Y
M
I
Q
Q
A
L
K
N
E
L
R
K
R
G
M
E
K
K
V
V
T
I
I
T
Q
T
I
V
D
K
N
D
P
A
F
Q
N
P
T
K
P
V
G
P
F
Y
D
E
E
T
A
K
R
L
A
R
-
E
K
G
W
I
V
K
EDSGR
G
W
R
R
V
V
P
SPDPKGHVE
A
E
T
I
K
K
L
V
E
R
GVIV
I
--
A
S
G
G
G
G
V
P
V
I
L
E
D
G
E
I
K
G
V
E
A
V
-
I
----
D
-
K
D
L
A
G
E
-
K
L
A
E
E
-
V
N
A
D
I
F
M
I
L
T
D
V
---
N
G
A
A
L
YYGTE
K
E
Q
----
W
L
R
E
V
K
V
E
E
L
R
K
Y
Y
E
E
G
H
F
K
A
G
S
-
M
G
P
K
V
L
A
--
A
--
I
R
F
I
E
W
GGE
R
A
I
I
A
H
L
E
K
A
V
E
A
L
E
G
K
T
G
T
Q
V
L
P----------
10
HHSearch
69.83
21%
-81
- C2 -
2INR
-
PARC_STAAS
A:
[385-474]
--------------------------------------------------
T
K
F
E
L
D
N
--------
A
E
K
R
M
H
I
V
E
G
L
I
K
A
L
S
I
L
D
K
V
I
E
-----
L
I
R
-----
S
S
K
N
K
R
D
A
K
E
N
L
I
E
----------------------------------
V
Y
E
F
T
E
E
Q
A
E
A
I
V
M
L
Q
L
Y
R
L
T
N
T
D
I
V
A
L
E
G
E
H
K
E
L
E
A
L
I
K
Q
L
-----
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
66.17
20%
-30
- C2 -
3WR7
2
?
A:
[2-110]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
L
R
P
L
E
R
E
D
L
R
Y
V
H
Q
L
D
N
N
-
A
S
V
---------------------------------------
M
--
R
Y
W
F
E
--
E
P
Y
E
A
F
V
E
L
S
D
L
Y
D
K
H
I
----
H
-
D
Q
S
E
R
R
-
F
V
V
E
C
-
D
G
E
K
A
G
L
V
E
L
V
E
INH
V
---------
H
R
R
----
A
E
F
Q
I
I
I
S
P
E
Y
Q
G
K
G
L
A
T
R
A
A
K
L
-
A
M
D
Y
G
F
T
--
V
---------------------------------------------
12
HHSearch
65.48
22%
-79
- C2 -
1ZVU
-
PARC_ECOLI
A:
[362-466]
--------------------------------------------------
L
N
Y
R
L
E
K
--------
V
L
K
R
L
H
I
L
E
G
L
L
V
A
F
L
N
I
D
E
V
I
E
-----
I
I
R
-----
N
E
D
E
---
P
K
P
A
L
M
S
----------------------------------
R
F
G
L
T
E
T
Q
A
E
A
I
L
E
L
K
L
R
H
L
A
K
L
E
E
M
K
I
R
G
E
Q
S
E
L
E
K
E
R
D
Q
L
-----
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
65.45
21%
-81
- C2 -
4I3H
-
?
A:
[1009-1098]
--------------------------------------------------
S
R
F
D
K
E
K
--------
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
-----
L
I
R
-----
A
S
E
N
K
A
D
A
K
E
N
L
K
V
----------------------------------
S
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
-----
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
62.25
21%
-71
- C2 -
2NOV
-
PARC_STRPN
A:
[361-450]
--------------------------------------------------
S
R
F
D
K
E
K
--------
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
-----
L
I
R
-----
A
S
E
N
K
A
D
A
K
E
N
L
K
V
-----------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
-----
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
61.85
11%
-37
- C2 -
1P0H
2
MSHD_MYCTU
A:
[6-313]
A
L
D
W
R
SALT
A
D
E
Q
R
S
V
R
A
L
V
T
A
T
T
A
V
D
GVAPVG
E
Q
V
L
R
E
L
G
Q
Q
R
T
E
H
L
L
V
A
G
S
R
P
G
G
PII
G
Y
L
N
L
S
P
P
G
G
A
M
A
E
L
V
V
H
P
Q
S
R
R
R
G
I
G
T
-----
A
M
A
-----
R
A
A
L
A
K
T
A
G
R
N
Q
F
W
----------------------------------
A
H
G
T
L
D
P
A
R
A
T
A
S
A
L
G
L
V
G
V
R
E
L
I
Q
M
R
R
P
L
R
-----------------
D
I
P
E
P
T
I
P
D
G
V
V
I
R
T
Y
A
G
T
S
D
D
A
E
L
L
R
V
N
N
-
A
A
F
--------------------------------------------
A
G
H
P
E
Q
G
G
W
T
A
V
Q
L
A
E
R
R
G
E
-
A
----
W
-
F
D
P
D
G
L
-
I
L
A
F
G
-
D
G
R
L
L
G
F
H
W
T
K
V
---
H
---------
P
D
H
PGLG
E
V
Y
V
L
G
V
D
P
A
A
Q
R
R
G
L
G
Q
M
L
T
S
I
-
G
I
V
S
L
A
R
--
R
--
L
V
E
P
A
------
V
L
L
Y
V
E
S
D
N
V
A
A
V
R
T
Y
Q
S
L
GFTTY
S
V
D
T
A
Y
A
L
28
HHSearch
60.63
11%
-39
- C2 -
4J3G
4
?
A:
[22-143]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
L
L
I
R
H
A
T
E
A
D
L
P
A
L
L
A
I
Y
N
D
-
A
V
E
---------------------------------------
N
--
T
L
A
I
W
N
-
E
T
L
V
D
L
E
N
R
H
Q
W
L
E
N
-
R
----
N
-
R
D
G
F
P
V
-
L
V
A
E
R
-
E
G
Q
V
V
G
Y
A
S
Y
G
P
F--
R
PFEGF----
R
H
S
----
S
E
L
S
V
Y
V
A
S
N
A
R
G
G
G
I
G
R
T
L
L
A
E
-
L
I
E
E
A
R
E
R
-
K
--
V
H
V
L
I
------
A
G
I
-----------------------------
16
HHSearch
58.89
18%
-93
- C2 -
2XKJ
-
?
E:
[630-716]
--------------------------------------------------
L
Q
Y
H
L
N
R
--------
I
E
K
R
L
H
I
L
A
G
L
L
I
A
Y
L
D
I
D
T
V
I
R
-----
I
I
R
-----
E
E
D
Q
---
P
K
P
V
L
M
E
----------------------------------
H
F
N
I
D
E
I
Q
A
E
A
I
L
E
L
K
L
R
H
L
A
K
L
E
E
M
E
I
R
H
E
Q
D
E
L
S
A
K
A
A
I
I
-----
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
56.79
17%
-45
- C2 -
3TTH
-
?
A:
[5-115]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
I
R
L
S
A
L
E
R
E
D
L
K
F
V
H
E
L
N
N
N
---
I
---------------------------------------
M
--
S
Y
W
F
E
E
-
P
Y
E
S
Y
R
E
L
E
D
L
H
I
K
H
-
I
----
H
D
Q
S
E
R
R
F
-
I
I
K
D
L
-
K
D
N
K
V
G
L
V
E
L
T
E
IDF
I
---------
H
R
R
----
C
E
F
A
I
I
I
S
P
G
E
E
G
K
G
Y
A
T
E
A
T
D
L
-
T
V
E
Y
A
F
S
--
I
---------------------------------------------
20
HHSearch
56.65
16%
-21
- C2 -
2VI7
3
?
A:
[7-128]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
R
L
E
R
Y
S
E
R
H
V
E
G
L
T
A
L
Y
N
D
-
P
A
V
---------------------------------------
A
--
R
Q
V
L
Q
-
M
P
Y
Q
S
V
E
Q
R
R
K
R
L
H
D
S
------
D
-
D
D
R
L
L
I
-
L
V
A
L
H
-
Q
G
D
V
I
G
S
A
S
L
E
Q
---
H
PRIRR----
S
H
S
----
G
S
I
G
M
G
V
A
V
A
W
Q
G
K
G
V
G
S
R
L
L
G
E
-
L
L
D
I
A
D
N
--
W
MN
L
R
R
V
E
------
L
T
V
Y
----------------------------
24
HHSearch
55.75
10%
-39
- C2 -
3R9F
2
?
A:
[17-145]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
N
D
E
I
T
L
L
Y
P
A
L
K
Y
A
E
E
L
Y
L
L
I
N
Q
-
N
K
I
---------------------------------------
N
F
I
K
S
M
A
W
P
-
A
F
V
N
N
I
S
D
S
V
S
F
I
E
Q
-
S
M
I
D
N
Q
-
N
E
K
A
L
I
-
L
F
I
K
Y
-
K
T
K
I
A
G
V
V
S
F
N
I
---
I
DHA------
N
K
T
----
A
Y
I
G
Y
W
L
G
A
N
F
Q
G
K
G
I
V
T
N
A
I
N
K
-
L
I
Q
E
Y
G
D
SG
V
--
I
K
R
F
V
------
I
K
C
-----------------------------
23
HHSearch
55.70
15%
-27
- C2 -
2FSR
2
?
A:
[29-142]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
R
T
E
R
L
T
L
R
P
L
A
M
A
D
F
P
A
Y
R
D
F
M
A
S
-
P
R
S
---------------------------------------
T
--
G
V
G
G
P
Y
-
D
L
P
S
T
W
G
V
F
C
H
D
L
A
N
W
H
----
F
-
F
G
H
G
A
L
-
M
I
D
L
G
E
T
G
E
C
I
G
Q
I
G
I
N
H
---
G
PL-------
F
P
E
----
K
E
L
G
W
L
L
Y
E
G
H
E
G
R
G
Y
A
A
E
A
A
V
A
-
L
R
D
W
A
F
E
------------------------------------------------
26
HHSearch
55.16
11%
-44
- C2 -
1S7K
-
?
A:
[6-124]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
S
T
T
L
E
L
R
A
A
D
E
S
H
V
P
A
L
H
Q
L
V
L
K
N------------------------------------------------------------
T
R
K
H
V
Q
G
-
N
I
L
L
H
Q
-
R
G
Y
A
K
M
-
Y
L
I
F
C
-
Q
N
E
M
A
G
V
L
S
F
N
A
IEP
I
---------
N
K
A
----
A
Y
I
G
Y
W
L
D
E
S
F
Q
G
Q
G
I
M
S
Q
S
L
Q
A
-
L
M
T
H
Y
A
R
--
R
---------------------------------------------
17
HHSearch
54.49
11%
-36
- C2 -
3FBU
1
?
A:
[3-125]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
E
R
L
L
I
R
K
F
E
F
K
D
W
E
A
V
H
E
Y
T
S
D
-
S
D
V
---------------------------------------
M
--
K
Y
I
P
E
--
G
V
-
F
T
E
E
D
T
R
N
F
V
N
K
-
N
----
M
G--
A
K
N
F
P
V
I
L
I
G
-
E
N
I
L
V
G
H
I
V
F
H
K
Y
F
-
G
---------
E
H
T
----
Y
E
I
G
W
V
F
N
P
K
Y
F
N
K
G
Y
A
S
E
A
A
Q
A
-
T
L
K
Y
G
F
K
--
E
--
M
K
L
H
R
------
I
I
A
T
C
Q
--------------------------
33
Fugue
53.53
11%
-34
- C2 -
1EB6
4
NPII_ASPOR
A:
[1-177]
------------------------------------------------------
T
E
V
--------
T
D
C
K
G
D
A
E
S
S
L
T
T
A
L
S
N
A
A
K
L
A
N
-----
Q
A
A
-----
E
A
A
E
S
G
D
-
E
S
K
F
E
E
----------------------------------
Y
F
K
T
T
D
Q
Q
T
R
T
T
V
A
E
R
L
R
A
V
A
K
E
A
G
S
-------
T
S
G
G
S
T
T
Y
H
-----
C
N
D
P
Y
G
Y
C
E
P
N
V
L
A
Y
T
L
P
S
K
N
E
I
A
N
C
D
I
Y
Y
S
-
E
L
P
---------------------------------------
P
--
L
A
Q
K
C
H
A
Q
D
-----------------------------------------
Q
A
T
T
T
---
L
---------
H
E
F
----
T
H
A
P
G
V
Y
Q
P
G
T
E
D
L
G
Y
G
Y
D
A
A
T
Q
L
S
A
Q
D
A
L
N
--
N
--
A
D
S
Y
A
------
L
Y
A
N
A
I
E
L
K
C
----------------------