@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0769: (2016-04-25 )
MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFGGIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIVNQSSTAAWLYSNFYGLAKVGVNGLTQQLARELGGMKIRINAIAPGPIDTEATRTVTPAELVKNMVQTIPLSRMGTPEDLVGMCLFLLSDSASWITGQIFNVDGGQIIRS
Atome Classification :
(35 SA)
...--......10........20........30....-....40........50....-...-..60........70........80........90......------..100.......110.......120.......130....-.....140.....---.-----.150---.---.----.......160.......170.......180....---...190..---.-----.-...200.......210.......220.......230.......240......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFD--S
K
V
A
I
V
T
G
A
A
Q
G
I
G
Q
A
Y
A
Q
A
L
A
REG
A
S
V
V
V
A
D-INAD
G
A
A
A
V
A
K
Q
I
V
A-DGG
T
-
A
I
H
-
V
PVDVSD
E
D
S
A
K
A
M
V
D
R
A
V
G
AFG
G
I
D
Y
L
VNN
A
A
I
YG
G
M
K
L
------
D
L
L
L
TV
P
L
D
Y
Y
K
K
F
MSVNHD
G
V
L
V
C
T
R
A
V
Y
K
H
M
--
A
K
RG-G
G
A
I
VNQSS
T
A
A
W
---
L
-----
Y
S
-----N---F----Y
G
L
A
K
V
G
V
N
G
L
T
Q
Q
L
A
R
E
LGG
M
K
I
R
I
N
A
IAPGPI---DTEATRTV---
T
-----
P
-
A
E
L
V
K
N
M
V
Q
TIPLSRMG
T
P
E
D
L
V
G
M
C
L
F
L
LSDSAS
W
I
T
G
Q
I
F
NVDG
G
Q
I
IRS
118
HHSearch
85.75
81%
-130
- C1 -
3QIV
-
?
A:
[3-241]
-
F
E
--
N
K
V
G
I
V
T
G
S
G
G
G
I
G
Q
A
Y
A
E
A
L
A
R
E
G
A
A
V
V
V
A
D
-
I
N
A
E
A
A
E
A
V
A
K
Q
I
V
A
-
D
G
G
T
-
A
I
S
-
V
A
V
D
V
S
D
P
E
S
A
K
A
M
A
D
R
T
L
A
E
F
G
G
I
D
Y
L
V
N
N
A
A
I
F
G
G
M
K
L
------
D
F
L
L
T
I
D
P
E
Y
Y
K
K
F
M
S
V
N
L
D
G
A
L
W
C
T
R
A
V
Y
K
K
M
--
T
K
R
G
-
G
G
A
I
V
N
Q
S
S
-------------------------------
L
A
K
V
G
I
N
G
L
T
Q
Q
L
S
R
E
L
G
G
R
N
I
R
I
N
A
I
A
P
-------------------------------------------
P
D
D
L
V
G
M
C
L
F
L
L
S
D
E
A
S
W
I
T
G
Q
I
F
N
V
--------
1
PsiBlast_PDB
85.44
80%
-130
- C1 -
3QIV
-
?
A:
[3-241]
-
F
E
--
N
K
V
G
I
V
T
G
S
G
G
G
I
G
Q
A
Y
A
E
A
L
A
R
E
G
A
A
V
V
V
A
D
-
I
N
A
E
A
A
E
A
V
A
K
Q
I
V
A
-
D
G
G
T
-
A
I
S
-
V
A
V
D
V
S
D
P
E
S
A
K
A
M
A
D
R
T
L
A
E
F
G
G
I
D
Y
L
V
N
N
A
A
I
F
G
G
M
K
L
------
D
F
L
L
T
I
D
P
E
Y
Y
K
K
F
M
S
V
N
L
D
G
A
L
W
C
T
R
A
V
Y
K
K
M
--
T
K
R
G
-
G
G
A
I
V
N
Q
S
S
-------------------------------
L
A
K
V
G
I
N
G
L
T
Q
Q
L
S
R
E
L
G
G
R
N
I
R
I
N
A
I
A
P
-------------------------------------------
P
D
D
L
V
G
M
C
L
F
L
L
S
D
E
A
S
W
I
T
G
Q
I
F
N
V
--------
43
PsiBlast_CBE
79.26
35%
-108
- C1 -
3R1I
1
?
A:
[27-272]
L
F
D
LS
G
K
R
A
L
I
T
G
A
S
T
G
I
G
K
K
V
A
L
A
Y
A
E
A
G
A
Q
V
A
V
A
A
-
R
H
S
D
A
L
Q
V
V
A
D
E
I
A
G
-
V
G
G
K
-
A
L
P
-
I
R
C
D
V
T
Q
P
D
Q
V
R
G
M
L
D
Q
M
T
G
E
L
G
G
I
D
I
A
V
C
N
A
G
I
---
V
S
V
------
Q
A
M
L
D
M
P
L
E
E
F
Q
R
I
Q
D
T
N
V
T
G
V
F
L
T
A
Q
A
A
A
R
A
M
--
V
D
Q
G
L
G
G
T
I
I
T
T
A
S
M
S
G
H
---
I
-----
I
N
I
PQQV
S
---
H
----
Y
C
T
S
K
A
A
V
V
H
L
T
K
A
M
A
V
E
L
A
P
H
Q
I
R
V
N
S
V
S
P
G
Y
I
---
R
T
E
L
V
E
P
L
-----------
A
D
Y
H
A
L
W
E
P
K
I
P
L
G
R
M
G
R
P
E
E
L
T
G
L
Y
L
Y
L
A
S
A
A
S
S
Y
M
T
G
S
D
I
V
I
D
G
G
-----
125
HHSearch
77.94
42%
-108
- C1 -
3GAF
-
?
A:
[9-251]
-
L
N
--
D
A
V
A
I
V
T
G
A
A
A
G
I
G
R
A
I
A
G
T
F
A
K
A
G
A
S
V
V
V
T
D
-
L
K
S
E
G
A
E
A
V
A
A
A
I
R
Q
-
A
G
G
K
-
A
I
G
-
L
E
C
N
V
T
D
E
Q
H
R
E
A
V
I
K
A
A
L
D
Q
F
G
K
I
T
V
L
V
N
N
A
G
G
G
G
P
K
P
----------
F
D
M
P
M
S
D
F
E
W
A
F
K
L
N
L
F
S
L
F
R
L
S
Q
L
A
A
P
H
M
--
Q
K
A
G
-
G
G
A
I
L
N
I
S
S
M
A
G
E
---
N
T
N
V
--
R
M
-----
A
---
S
----
Y
G
S
S
K
A
A
V
N
H
L
T
R
N
I
A
F
D
V
G
P
M
G
I
R
V
N
A
I
A
P
G
A
I
---
K
T
D
A
L
A
T
V
---
L
-----
T
-
P
E
I
E
R
A
M
L
K
H
T
P
L
G
R
L
G
E
A
Q
D
I
A
N
A
A
L
F
L
C
S
P
A
A
A
W
I
S
G
Q
V
L
T
V
S
G
G
G
V
---
37
PsiBlast_CBE
77.65
35%
-103
- C1 -
4JRO
1
?
C:
[30-271]
------
K
V
A
V
V
T
G
G
S
R
G
I
G
R
D
I
A
I
N
L
A
K
E
G
A
N
I
F
F
N
Y
-
N
G
S
P
E
A
A
E
E
T
A
K
L
V
A
-
E
H
G
V
-
E
V
E
A
M
K
A
N
V
A
I
A
E
D
V
D
A
F
F
K
Q
A
I
E
R
F
G
R
V
D
I
L
V
N
N
A
G
I
---
T
R
D
------
N
L
L
M
R
M
K
E
D
E
W
D
D
V
I
N
I
N
L
K
G
T
F
L
C
T
K
A
V
S
R
T
M
--
M
K
Q
R
-
A
G
K
I
I
N
M
A
S
V
V
G
L
---
I
GNAG-
Q
A
-----
N
---
Y
----
V
A
-
S
K
A
G
V
I
G
L
T
K
T
T
A
R
E
L
A
P
R
G
I
N
V
N
A
V
A
P
G
F
I
---
T
T
D
M
T
D
K
L
---
D
-----
E
--
K
T
K
E
A
M
L
A
Q
I
P
L
G
A
Y
G
T
T
E
D
I
A
N
A
V
L
F
L
A
S
D
A
S
K
Y
I
T
G
Q
T
L
S
V
D
G
G
M
V
M
--
49
PsiBlast_CBE
77.31
36%
-107
- C1 -
2EWM
2
PED_AROAE
B:
[8-247]
------
K
L
A
V
I
T
G
G
A
N
G
I
G
R
A
I
A
E
R
F
A
V
E
G
A
D
I
A
I
A
D
L
V
P
A
P
E
A
E
A
A
I
R
N
L
----
G
R
R
-
V
L
T
-
V
K
C
D
V
S
Q
P
G
D
V
E
A
F
G
K
Q
V
I
S
T
F
G
R
C
D
I
L
V
N
N
A
G
I
Y
P
L
I
P
F
------
D
E
L
T
---
F
E
Q
W
K
K
T
F
E
I
N
V
D
S
G
F
L
M
A
K
A
F
V
P
G
M
--
K
R
N
G
-
W
G
R
I
I
N
L
T
S
T
T
Y
W
---
L
K
I
E
A-
Y
T
-----
H
---
Y
----
I
S
T
K
A
A
N
I
-
G
F
T
R
A
L
A
S
D
L
G
K
D
G
I
T
V
N
A
I
A
P
S
L
V
RT
A
T
T
E
A
S
A
L
S
---
A
-----
M
-
F
D
V
L
P
N
M
L
Q
A
I
P
--
R
L
Q
V
P
L
D
L
T
G
A
A
A
F
L
A
S
D
D
A
S
F
I
T
G
Q
T
L
A
V
D
G
G
M
V
---
19
PsiBlast_PDB
77.07
35%
-102
- C1 -
4JRO
-
?
A:
[30-271]
------
K
V
A
V
V
T
G
G
S
R
G
I
G
R
D
I
A
I
N
L
A
K
E
G
A
N
I
F
F
N
Y
-
N
G
S
P
E
A
A
E
E
T
A
K
L
V
A
-
E
H
G
V
-
E
V
E
A
M
K
A
N
V
A
I
A
E
D
V
D
A
F
F
K
Q
A
I
E
R
F
G
R
V
D
I
L
V
N
N
A
G
I
---
T
R
D
------
N
L
L
M
R
M
K
E
D
E
W
D
D
V
I
N
I
N
L
K
G
T
F
L
C
T
K
A
V
S
R
T
M
--
M
K
Q
R
-
A
G
K
I
I
N
M
A
S
V
V
G
L
---
I
G
N
A
G-
Q
A
-----
N
---
Y
----
V
A
-
S
K
A
G
V
I
G
L
T
K
T
T
A
R
E
L
A
P
R
G
I
N
V
N
A
V
A
P
G
F
I
---
T
T
D
M
T
D
K
L
---
D
-----
E
--
K
T
K
E
A
M
L
A
Q
I
P
L
G
A
Y
G
T
T
E
D
I
A
N
A
V
L
F
L
A
S
D
A
S
K
Y
I
T
G
Q
T
L
S
V
D
G
G
M
V
M
--
40
PsiBlast_CBE
76.69
38%
-110
- C1 -
2D1Y
1
?
C:
[3-244]
L
F
A
--
G
K
G
V
L
V
T
G
G
A
R
G
I
G
R
A
I
A
Q
A
F
A
R
E
G
A
L
V
A
L
C
D
-
L
R
P
E
G
-
K
E
V
A
E
A
I
----
G
G
A
-
F
F
Q
---
V
D
L
E
D
E
R
E
R
V
R
F
V
E
E
A
A
Y
A
L
G
R
V
D
V
L
V
N
N
A
A
I
A
A
P
G
S
---------
A
L
T
V
R
L
P
E
W
R
R
V
L
E
V
N
L
T
A
P
M
H
L
S
A
L
A
A
R
E
M
--
R
K
V
G
-
G
G
A
I
V
N
V
A
S
V
Q
G
L
---
F
-----
A
E
-----
Q
EN
A
A
----
Y
N
A
S
K
G
G
L
V
N
L
T
R
S
L
A
L
D
L
A
P
L
R
I
R
V
N
A
V
A
P
G
A
I
---
A
T
E
A
V
L
E
A
---
I
A
L
SPD
P
-
E
R
T
R
R
D
W
E
D
L
H
A
L
R
R
L
G
K
P
E
E
V
A
E
A
V
L
F
L
A
S
E
K
A
S
F
I
T
G
A
I
L
P
V
D
G
G
-----
3
PsiBlast_PDB
76.66
41%
-109
- C1 -
3GAF
-
?
A:
[9-251]
-
L
N
--
D
A
V
A
I
V
T
G
A
A
A
G
I
G
R
A
I
A
G
T
F
A
K
A
G
A
S
V
V
V
T
D
-
L
K
S
E
G
A
E
A
V
A
A
A
I
R
Q
-
A
G
G
K
-
A
I
G
-
L
E
C
N
V
T
D
E
Q
H
R
E
A
V
I
K
A
A
L
D
Q
F
G
K
I
T
V
L
V
N
N
A
G
G
G
G
P
K
P
F
------
D
M
----
P
M
S
D
F
E
W
A
F
K
L
N
L
F
S
L
F
R
L
S
Q
L
A
A
P
H
M
--
Q
K
A
G
-
G
G
A
I
L
N
I
S
S
M
A
G
E
N
T
N
V
-----
R
M
-----
A
---
S
----
Y
G
S
S
K
A
A
V
N
H
L
T
R
N
I
A
F
D
V
G
P
M
G
I
R
V
N
A
I
A
P
G
A
I
---
K
T
D
A
L
A
T
V
---
L
-----
T
-
P
E
I
E
R
A
M
L
K
H
T
P
L
G
R
L
G
E
A
Q
D
I
A
N
A
A
L
F
L
C
S
P
A
A
A
W
I
S
G
Q
V
L
T
V
S
G
G
G
V
---
30
PsiBlast_CBE
75.78
39%
-108
- C1 -
4NBW
1
?
B:
[5-257]
-----
K
R
V
A
I
I
T
G
A
A
N
G
I
G
R
A
T
A
L
E
F
A
Q
A
G
Y
H
V
V
A
W
D
-
L
A
E
E
A
G
A
A
L
I
A
E
I
A
D
-
A
G
G
S
-
A
D
F
-
A
R
V
D
V
S
A
A
E
S
V
E
A
A
V
A
E
I
I
A
E
H
G
R
V
D
V
L
V
N
N
A
G
I
L
H
D
G
Q
L
VKVKGG
E
V
V
K
K
M
A
E
A
Q
F
D
A
V
I
S
V
N
L
K
G
V
F
L
C
T
Q
A
V
A
P
H
M
--
I
A
A
K
-
Y
G
R
I
L
N
A
S
S
V
V
G
----
L
-----
Y
G
-----
N
---
F
GQTN
Y
V
A
A
K
S
G
V
I
G
M
T
K
V
W
A
R
E
L
G
R
Y
G
I
T
V
N
A
I
A
P
G
F
I
---
A
T
E
M
V
Q
Q
M
---------
P
-
E
R
V
L
E
A
M
V
A
R
T
P
V
G
R
I
G
D
P
V
D
I
A
R
A
Y
L
F
L
A
S
E
E
S
G
F
I
S
G
T
T
L
S
V
D
G
G
M
V
V
G
S
133
HHSearch
75.52
33%
-107
- C1 -
3AWD
-
?
A:
[11-259]
-
L
D
--
N
R
V
A
I
V
T
G
G
A
Q
N
I
G
L
A
C
V
T
A
L
A
E
A
G
A
R
V
I
I
A
D
-
L
D
E
A
M
A
T
K
A
V
E
D
L
R
M
-
E
G
H
D
-
V
S
S
-
V
V
M
D
V
T
N
T
E
S
V
Q
N
A
V
R
S
V
H
E
Q
E
G
R
V
D
I
L
V
A
C
A
G
I
C
I
S
E
V
--------
K
A
E
D
M
T
D
G
Q
W
L
K
Q
V
D
I
N
L
N
G
M
F
R
S
C
Q
A
V
G
R
I
M
--
L
E
Q
K
-
Q
G
V
I
V
A
I
G
S
M
S
G
L
---
I
V
N
R
PQ
Q
Q
-----
A
---
A
----
Y
N
A
S
K
A
G
V
H
Q
Y
I
R
S
L
A
A
E
W
A
P
H
G
I
R
A
N
A
V
A
P
T
Y
I
---
E
T
T
L
T
R
F
G
---
M
-----
E
K
P
E
L
Y
D
A
W
I
A
G
T
P
M
G
R
V
G
Q
P
D
E
V
A
S
V
V
Q
F
L
A
S
D
A
A
S
L
M
T
G
A
I
V
N
V
D
A
G
F
T
V
--
80
PsiBlast_CBE
75.33
35%
-107
- C1 -
1VL8
3
?
B:
[16-263]
V
F
D
LR
G
R
V
A
L
V
T
G
G
S
R
G
L
G
F
G
I
A
Q
G
L
A
E
A
G
C
S
V
V
V
A
S
-
R
N
L
E
E
A
S
E
A
A
Q
K
L
T
E
-
K
Y
G
V
E
T
M
A
-
F
R
C
D
V
S
N
Y
E
E
V
K
K
L
L
E
A
V
K
E
K
F
G
K
L
D
T
V
V
N
A
A
G
I
N
R
R
H
P
A
------
E
---
E
F
P
L
D
E
F
R
Q
V
I
E
V
N
L
F
G
T
Y
Y
V
C
R
E
A
F
S
L
L
--
R
E
S
D
-
N
P
S
I
I
N
I
G
S
L
T
V
E
---
E
-----
V
T
MPNI-
S
---
A
----
Y
A
A
S
K
G
G
V
A
S
L
T
K
A
L
A
K
E
W
G
R
Y
G
I
R
V
N
V
I
A
P
G
W
Y
---
R
T
K
M
T
E
A
V
F
--
S
-----
D
-
P
E
K
L
D
Y
M
L
K
R
I
P
L
G
R
T
G
V
P
E
D
L
K
G
V
A
V
F
L
A
S
E
E
A
K
Y
V
T
G
Q
I
I
F
V
D
G
G
-----
131
HHSearch
75.23
38%
-108
- C1 -
1FMC
2
HDHA_ECOLI
A:
[9-252]
-
L
D
--
G
K
C
A
I
I
T
G
A
G
A
G
I
G
K
E
I
A
I
T
F
A
T
A
G
A
S
V
V
V
S
D
-
I
N
A
D
A
A
N
H
V
V
D
E
I
Q
Q
-
L
G
G
Q
-
A
F
A
-
C
R
C
D
I
T
S
E
Q
E
L
S
A
L
A
D
F
A
I
S
K
L
G
K
V
D
I
L
V
N
N
A
G
G
G
G
P
K
P
----------
F
D
M
P
M
A
D
F
R
R
A
Y
E
L
N
V
F
S
F
F
H
L
S
Q
L
V
A
P
E
M
--
E
K
N
G
-
G
G
V
I
L
T
I
T
S
M
A
A
E
---
N
K
N
I
--
N
M
-----
T
---
S
----
Y
A
S
S
K
A
A
A
S
H
L
V
R
N
M
A
F
D
L
G
E
K
N
I
R
V
N
G
I
A
P
G
A
I
---
L
T
D
A
L
K
S
V
---
I
-----
T
-
P
E
I
E
Q
K
M
L
Q
H
T
P
I
R
R
L
G
Q
P
Q
D
I
A
N
A
A
L
F
L
C
S
P
A
A
S
W
V
S
G
Q
I
L
T
V
S
G
G
G
V
Q
--
81
PsiBlast_CBE
75.09
35%
-106
- C1 -
1VL8
2
?
A:
[17-263]
-
F
D
LR
G
R
V
A
L
V
T
G
G
S
R
G
L
G
F
G
I
A
Q
G
L
A
E
A
G
C
S
V
V
V
A
S
-
R
N
L
E
E
A
S
E
A
A
Q
K
L
T
E
-
K
Y
G
V
E
T
M
A
-
F
R
C
D
V
S
N
Y
E
E
V
K
K
L
L
E
A
V
K
E
K
F
G
K
L
D
T
V
V
N
A
A
G
I
N
R
R
H
P
A
------
E
---
E
F
P
L
D
E
F
R
Q
V
I
E
V
N
L
F
G
T
Y
Y
V
C
R
E
A
F
S
L
L
--
R
E
S
D
-
N
P
S
I
I
N
I
G
S
L
T
V
E
---
E
-----
V
T
MPNI-
S
---
A
----
Y
A
A
S
K
G
G
V
A
S
L
T
K
A
L
A
K
E
W
G
R
Y
G
I
R
V
N
V
I
A
P
G
W
Y
---
R
T
K
M
T
E
A
V
F
--
S
-----
D
-
P
E
K
L
D
Y
M
L
K
R
I
P
L
G
R
T
G
V
P
E
D
L
K
G
V
A
V
F
L
A
S
E
E
A
K
Y
V
T
G
Q
I
I
F
V
D
G
G
-----
21
PsiBlast_CBE
75.08
38%
-110
- C1 -
4NBU
2
?
D:
[11-247]
-
L
Q
--
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
-
F
N
E
----
A
A
G
K
E
A
V
E
-
A
N
P
G
-
V
V
F
-
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
---
T
R
D
------
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
--
A
E
Q
G
-
K
G
K
I
I
N
T
S
S
V
T
G
----
T
-----
Y
G
-----
N
---
V
GQTN
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
G
F
T
---
E
T
A
M
V
A
E
V
---------
P
-
E
K
V
I
E
K
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
-----
41
PsiBlast_CBE
75.02
38%
-111
- C1 -
2D1Y
1
?
B:
[3-244]
L
F
A
--
G
K
G
V
L
V
T
G
G
A
R
G
I
G
R
A
I
A
Q
A
F
A
R
E
G
A
L
V
A
L
C
D
-
L
R
P
E
G
-
K
E
V
A
E
A
I
----
G
G
A
-
F
F
Q
---
V
D
L
E
D
E
R
E
R
V
R
F
V
E
E
A
A
Y
A
L
G
R
V
D
V
L
V
N
N
A
A
I
A
A
P
G
S
---------
A
L
T
V
R
L
P
E
W
R
R
V
L
E
V
N
L
T
A
P
M
H
L
S
A
L
A
A
R
E
M
--
R
K
V
G
-
G
G
A
I
V
N
V
A
S
V
Q
G
L
---
F
-----
A
E
-----
Q
EN
A
A
----
Y
N
A
S
K
G
G
L
V
N
L
T
R
S
L
A
L
D
L
A
P
L
R
I
R
V
N
A
V
A
P
G
A
I
---
A
T
E
A
V
L
E
A
---
I
--------
R
T
R
R
D
W
E
D
L
H
A
L
R
R
L
G
K
P
E
E
V
A
E
A
V
L
F
L
A
S
E
K
A
S
F
I
T
G
A
I
L
P
V
D
G
G
-----
29
PsiBlast_CBE
74.94
39%
-103
- C1 -
4NBW
1
?
C:
[5-257]
-----
K
R
V
A
I
I
T
G
A
A
N
G
I
G
R
A
T
A
L
E
F
A
Q
A
G
Y
H
V
V
A
W
D
-
L
A
E
E
A
G
A
A
L
I
A
E
I
A
D
-
A
G
G
S
-
A
D
F
-
A
R
V
D
V
S
A
A
E
S
V
E
A
A
V
A
E
I
I
A
E
H
G
R
V
D
V
L
V
N
N
A
G
I
L
H
D
G
Q
L
VKVKGG
E
V
V
K
K
M
A
E
A
Q
F
D
A
V
I
S
V
N
L
K
G
V
F
L
C
T
Q
A
V
A
P
H
M
--
I
A
A
K
-
Y
G
R
I
L
N
A
S
S
V
V
G
----
L
-----
Y
G
-----
N
---
F
GQTN
Y
V
A
A
K
S
G
V
I
G
M
T
K
V
W
A
R
E
L
G
R
Y
G
I
T
V
N
A
I
A
P
G
F
I
---
A
T
E
M
V
Q
Q
M
---------
P
-
E
R
V
L
E
A
M
V
A
R
T
P
V
G
R
I
G
D
P
V
D
I
A
R
A
Y
L
F
L
A
S
E
E
S
G
F
I
S
G
T
T
L
S
V
D
G
G
M
V
V
G
S
119
HHSearch
74.85
34%
-96
- C1 -
2CFC
2
HCDR_XANP2
A:
[1-249]
--
M
--
S
R
V
A
I
V
T
G
A
S
S
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
-
L
S
A
E
T
L
E
E
T
A
R
T
H
W
H
A
Y
A
D
K
-
V
L
R
-
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
G
N
S
E
A
------
G
V
L
H
T
T
P
V
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
--
L
L
Q
G
-
A
G
V
I
V
N
I
A
S
V
A
S
L
---
V
AFP--
G
R
-----
S
---
A
----
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
G
M
I
---
E
T
P
M
T
Q
W
R
---
L
D
----
Q
-
P
E
L
R
D
Q
V
L
A
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
Y
T
A
--
23
PsiBlast_CBE
74.84
38%
-109
- C1 -
4NBU
2
?
B:
[11-247]
-
L
Q
--
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
-
F
N
E
----
A
A
G
K
E
A
V
E
-
A
N
P
G
-
V
V
F
-
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
---
T
R
D
------
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
--
A
E
Q
G
-
K
G
K
I
I
N
T
S
S
V
T
G
----
T
-----
Y
G
-----
N
---
V
GQ
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
G
F
T
---
E
T
A
M
V
A
E
V
---------
P
-
E
K
V
I
E
K
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
-----
12
PsiBlast_PDB
74.82
39%
-106
- C1 -
4NBW
1
?
A:
[5-257]
-----
K
R
V
A
I
I
T
G
A
A
N
G
I
G
R
A
T
A
L
E
F
A
Q
A
G
Y
H
V
V
A
W
D
-
L
A
E
E
A
G
A
A
L
I
A
E
I
A
D
-
A
G
G
S
-
A
D
F
-
A
R
V
D
V
S
A
A
E
S
V
E
A
A
V
A
E
I
I
A
E
H
G
R
V
D
V
L
V
N
N
A
G
I
L
H
D
G
Q
L
V
K
V
K
GG
E
V
V
K
K
M
A
E
A
Q
F
D
A
V
I
S
V
N
L
K
G
V
F
L
C
T
Q
A
V
A
P
H
M
--
I
A
A
K
-
Y
G
R
I
L
N
A
S
S
V
V
G
----
L
-----
Y
G
-----
N
---
F
GQ
T
N
Y
V
A
A
K
S
G
V
I
G
M
T
K
V
W
A
R
E
L
G
R
Y
G
I
T
V
N
A
I
A
P
G
F
I
---
A
T
E
M
V
Q
Q
M
---------
P
-
E
R
V
L
E
A
M
V
A
R
T
P
V
G
R
I
G
D
P
V
D
I
A
R
A
Y
L
F
L
A
S
E
E
S
G
F
I
S
G
T
T
L
S
V
D
G
G
M
V
V
G
S
2
PsiBlast_PDB
74.69
38%
-110
- C1 -
4NBU
1
?
A:
[11-247]
-
L
Q
--
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
-
F
N
E
----
A
A
G
K
E
A
V
E
-
A
N
P
G
-
V
V
F
-
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
---
T
R
D
------
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
--
A
E
Q
G
-
K
G
K
I
I
N
T
S
S
V
T
G
----
T
-----
Y
G
-----
N
---
V
GQ
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
G
F
T
---
E
T
A
M
V
A
E
V
---------
P
-
E
K
V
I
E
K
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
-----
22
PsiBlast_CBE
74.67
38%
-111
- C1 -
4NBU
1
?
C:
[11-247]
-
L
Q
--
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
-
F
N
E
----
A
A
G
K
E
A
V
E
-
A
N
P
G
-
V
V
F
-
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
---
T
R
D
------
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
--
A
E
Q
G
-
K
G
K
I
I
N
T
S
S
V
T
G
----
T
-----
Y
G
-----
N
---
V
GQTN
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
G
F
T
---
E
T
A
M
V
A
E
V
---------
P
-
E
K
V
I
E
K
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
-----
69
PsiBlast_CBE
74.45
40%
-101
- C1 -
3NUG
2
PLDH_RHILO
C:
[7-245]
------
K
T
A
L
V
T
G
A
A
Q
G
I
G
K
A
I
A
A
R
L
A
A
D
G
A
T
V
I
V
S
D
-
I
N
A
E
G
A
K
A
A
A
A
S
I
----
G
K
K
-
A
R
A
-
I
A
A
D
I
S
D
P
G
S
V
K
A
L
F
A
E
I
Q
A
L
T
G
G
I
D
I
L
V
N
N
A
S
I
V
P
F
V
A
W
------
D
---
D
V
D
L
D
H
W
R
K
I
I
D
V
N
L
T
G
T
F
I
V
T
R
A
G
T
D
Q
M
RA
A
G
K
A
-
G
R
V
I
S
I
A
S
N
T
F
F
A
---
G
-----
T
P
-----
N
---
M
AA--
Y
V
A
A
K
G
G
V
I
G
F
T
R
A
L
A
T
E
L
G
K
Y
N
I
T
A
N
A
V
T
P
G
L
I
---
E
S
D
G
V
K
A
S
---
P
-----
H
-
N
E
A
F
G
F
V
E
M
L
Q
A
M
K
G
K
G
Q
P
E
H
I
A
D
V
V
S
F
L
A
S
D
D
A
R
W
I
T
G
Q
T
L
N
V
D
A
G
M
V
---
6
PsiBlast_PDB
73.88
37%
-108
- C1 -
1FMC
2
HDHA_ECOLI
A:
[9-249]
-
L
D
--
G
K
C
A
I
I
T
G
A
G
A
G
I
G
K
E
I
A
I
T
F
A
T
A
G
A
S
V
V
V
S
D
-
I
N
A
D
A
A
N
H
V
V
D
E
I
Q
Q
-
L
G
G
Q
-
A
F
A
-
C
R
C
D
I
T
S
E
Q
E
L
S
A
L
A
D
F
A
I
S
K
L
G
K
V
D
I
L
V
N
N
A
G
G
G
G
P
K
P
F
------
D
M
----
P
M
A
D
F
R
R
A
Y
E
L
N
V
F
S
F
F
H
L
S
Q
L
V
A
P
E
M
--
E
K
N
G
-
G
G
V
I
L
T
I
T
S
M
A
A
E
N
K
N
I
-----
N
M
-----
T
---
S
----
Y
A
S
S
K
A
A
A
S
H
L
V
R
N
M
A
F
D
L
G
E
K
N
I
R
V
N
G
I
A
P
G
A
I
---
L
T
D
A
L
K
S
V
---
I
-----
T
-
P
E
I
E
Q
K
M
L
Q
H
T
P
I
R
R
L
G
Q
P
Q
D
I
A
N
A
A
L
F
L
C
S
P
A
A
S
W
V
S
G
Q
I
L
T
V
S
G
G
-----
71
PsiBlast_CBE
73.85
40%
-103
- C1 -
3NUG
2
PLDH_RHILO
A:
[7-245]
------
K
T
A
L
V
T
G
A
A
Q
G
I
G
K
A
I
A
A
R
L
A
A
D
G
A
T
V
I
V
S
D
-
I
N
A
E
G
A
K
A
A
A
A
S
I
----
G
K
K
-
A
R
A
-
I
A
A
D
I
S
D
P
G
S
V
K
A
L
F
A
E
I
Q
A
L
T
G
G
I
D
I
L
V
N
N
A
S
I
V
P
F
V
A
W
------
D
---
D
V
D
L
D
H
W
R
K
I
I
D
V
N
L
T
G
T
F
I
V
T
R
A
G
T
D
Q
M
R
A
A
G
K
A
-
G
R
V
I
S
I
A
S
N
T
F
F
A
---
G
-----
T
P
-----
N
---
M
A
A
--
Y
V
A
A
K
G
G
V
I
G
F
T
R
A
L
A
T
E
L
G
K
Y
N
I
T
A
N
A
V
T
P
G
L
I
---
E
S
D
G
V
K
A
S
---
P
-----
H
-
N
E
A
F
G
F
V
E
M
L
Q
A
M
K
G
K
G
Q
P
E
H
I
A
D
V
V
S
F
L
A
S
D
D
A
R
W
I
T
G
Q
T
L
N
V
D
A
G
M
V
---
66
PsiBlast_CBE
73.19
40%
-101
- C1 -
3RWB
3
PLDH_RHILO
B:
[7-245]
------
K
T
A
L
V
T
G
A
A
Q
G
I
G
K
A
I
A
A
R
L
A
A
D
G
A
T
V
I
V
S
D
-
I
N
A
E
G
A
K
A
A
A
A
S
I
----
G
K
K
-
A
R
A
-
I
A
A
D
I
S
D
P
G
S
V
K
A
L
F
A
E
I
Q
A
L
T
G
G
I
D
I
L
V
N
N
A
S
I
V
P
F
V
A
W
------
D
---
D
V
D
L
D
H
W
R
K
I
I
D
V
N
L
T
G
T
F
I
V
T
R
A
G
T
D
Q
M
RA
A
G
K
A
-
G
R
V
I
S
I
A
S
N
T
F
F
A
---
G
-----
T
P
-----
N
---
M
AA--
Y
V
A
A
K
G
G
V
I
G
F
T
R
A
L
A
T
E
L
G
K
Y
N
I
T
A
N
A
V
T
P
G
L
I
---
E
S
D
G
V
K
A
S
---
P
-----
H
-
N
E
A
F
G
F
V
E
M
L
Q
A
M
K
G
K
G
Q
P
E
H
I
A
D
V
V
S
F
L
A
S
D
D
A
R
W
I
T
G
Q
T
L
N
V
D
A
G
M
V
---
65
PsiBlast_CBE
72.76
40%
-98
- C1 -
3RWB
4
PLDH_RHILO
C:
[7-245]
------
K
T
A
L
V
T
G
A
A
Q
G
I
G
K
A
I
A
A
R
L
A
A
D
G
A
T
V
I
V
S
D
-
I
N
A
E
G
A
K
A
A
A
A
S
I
----
G
K
K
-
A
R
A
-
I
A
A
D
I
S
D
P
G
S
V
K
A
L
F
A
E
I
Q
A
L
T
G
G
I
D
I
L
V
N
N
A
S
I
V
P
F
V
A
W
------
D
---
D
V
D
L
D
H
W
R
K
I
I
D
V
N
L
T
G
T
F
I
V
T
R
A
G
T
D
Q
M
RA
A
G
K
A
-
G
R
V
I
S
I
A
S
N
T
F
F
A
---
G
-----
T
P
-----
N
---
M
AA--
Y
V
A
A
K
G
G
V
I
G
F
T
R
A
L
A
T
E
L
G
K
Y
N
I
T
A
N
A
V
T
P
G
L
I
---
E
S
D
G
V
K
A
S
---
P
-----
H
-
N
E
A
F
G
F
V
E
M
L
Q
A
M
K
G
K
G
Q
P
E
H
I
A
D
V
V
S
F
L
A
S
D
D
A
R
W
I
T
G
Q
T
L
N
V
D
A
G
M
V
---
70
PsiBlast_CBE
72.65
40%
-103
- C1 -
3NUG
1
PLDH_RHILO
B:
[7-245]
------
K
T
A
L
V
T
G
A
A
Q
G
I
G
K
A
I
A
A
R
L
A
A
D
G
A
T
V
I
V
S
D
-
I
N
A
E
G
A
K
A
A
A
A
S
I
----
G
K
K
-
A
R
A
-
I
A
A
D
I
S
D
P
G
S
V
K
A
L
F
A
E
I
Q
A
L
T
G
G
I
D
I
L
V
N
N
A
S
I
V
P
F
V
A
W
------
D
---
D
V
D
L
D
H
W
R
K
I
I
D
V
N
L
T
G
T
F
I
V
T
R
A
G
T
D
Q
M
RA
A
G
K
A
-
G
R
V
I
S
I
A
S
N
T
F
F
A
---
G
-----
T
P
-----
N
---
M
AA--
Y
V
A
A
K
G
G
V
I
G
F
T
R
A
L
A
T
E
L
G
K
Y
N
I
T
A
N
A
V
T
P
G
L
I
---
E
S
D
G
V
K
A
S
---
P
-----
H
-
N
E
A
F
G
F
V
E
M
L
Q
A
M
K
G
K
G
Q
P
E
H
I
A
D
V
V
S
F
L
A
S
D
D
A
R
W
I
T
G
Q
T
L
N
V
D
A
G
M
V
---
64
PsiBlast_CBE
72.65
40%
-100
- C1 -
3RWB
3
PLDH_RHILO
D:
[7-245]
------
K
T
A
L
V
T
G
A
A
Q
G
I
G
K
A
I
A
A
R
L
A
A
D
G
A
T
V
I
V
S
D
-
I
N
A
E
G
A
K
A
A
A
A
S
I
----
G
K
K
-
A
R
A
-
I
A
A
D
I
S
D
P
G
S
V
K
A
L
F
A
E
I
Q
A
L
T
G
G
I
D
I
L
V
N
N
A
S
I
V
P
F
V
A
W
------
D
---
D
V
D
L
D
H
W
R
K
I
I
D
V
N
L
T
G
T
F
I
V
T
R
A
G
T
D
Q
M
RA
A
G
K
A
-
G
R
V
I
S
I
A
S
N
T
F
F
A
---
G
-----
T
P
-----
N
---
M
AA--
Y
V
A
A
K
G
G
V
I
G
F
T
R
A
L
A
T
E
L
G
K
Y
N
I
T
A
N
A
V
T
P
G
L
I
---
E
S
D
G
V
K
A
S
---
P
-----
H
-
N
E
A
F
G
F
V
E
M
L
Q
A
M
K
G
K
G
Q
P
E
H
I
A
D
V
V
S
F
L
A
S
D
D
A
R
W
I
T
G
Q
T
L
N
V
D
A
G
M
V
---
68
PsiBlast_CBE
72.38
40%
-103
- C1 -
3NUG
1
PLDH_RHILO
D:
[7-245]
------
K
T
A
L
V
T
G
A
A
Q
G
I
G
K
A
I
A
A
R
L
A
A
D
G
A
T
V
I
V
S
D
-
I
N
A
E
G
A
K
A
A
A
A
S
I
----
G
K
K
-
A
R
A
-
I
A
A
D
I
S
D
P
G
S
V
K
A
L
F
A
E
I
Q
A
L
T
G
G
I
D
I
L
V
N
N
A
S
I
V
P
F
V
A
W
------
D
---
D
V
D
L
D
H
W
R
K
I
I
D
V
N
L
T
G
T
F
I
V
T
R
A
G
T
D
Q
M
RA
A
G
K
A
-
G
R
V
I
S
I
A
S
N
T
F
F
A
---
G
-----
T
P
-----
N
---
M
AA--
Y
V
A
A
K
G
G
V
I
G
F
T
R
A
L
A
T
E
L
G
K
Y
N
I
T
A
N
A
V
T
P
G
L
I
---
E
S
D
G
V
K
A
S
---
P
-----
H
-
N
E
A
F
G
F
V
E
M
L
Q
A
M
K
G
K
G
Q
P
E
H
I
A
D
V
V
S
F
L
A
S
D
D
A
R
W
I
T
G
Q
T
L
N
V
D
A
G
M
V
---
67
PsiBlast_CBE
72.22
40%
-103
- C1 -
3RWB
4
PLDH_RHILO
A:
[7-245]
------
K
T
A
L
V
T
G
A
A
Q
G
I
G
K
A
I
A
A
R
L
A
A
D
G
A
T
V
I
V
S
D
-
I
N
A
E
G
A
K
A
A
A
A
S
I
----
G
K
K
-
A
R
A
-
I
A
A
D
I
S
D
P
G
S
V
K
A
L
F
A
E
I
Q
A
L
T
G
G
I
D
I
L
V
N
N
A
S
I
V
P
F
V
A
W
------
D
---
D
V
D
L
D
H
W
R
K
I
I
D
V
N
L
T
G
T
F
I
V
T
R
A
G
T
D
Q
M
R
A
A
G
K
A
-
G
R
V
I
S
I
A
S
N
T
F
F
A
---
G
-----
T
P
-----
N
---
M
A
A
--
Y
V
A
A
K
G
G
V
I
G
F
T
R
A
L
A
T
E
L
G
K
Y
N
I
T
A
N
A
V
T
P
G
L
I
---
E
S
D
G
V
K
A
S
---
P
-----
H
-
N
E
A
F
G
F
V
E
M
L
Q
A
M
K
G
K
G
Q
P
E
H
I
A
D
V
V
S
F
L
A
S
D
D
A
R
W
I
T
G
Q
T
L
N
V
D
A
G
M
V
---
34
PsiBlast_CBE
67.39
35%
-99
- C1 -
4WEC
5
?
C:
[31-269]
------
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
G
D
-
I
D
P
T
T
G
K
A
A
A
D
E
L
------
E
-
G
L
F
-
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
-
S
P
P
E
D
------
D
L
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
--
V
P
A
G
-
K
G
S
I
I
N
T
A
S
F
V
A
V
---
M
-----
G
S
-----
A
---
T
SQIS
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
G
I
R
V
N
A
L
C
P
G
P
V
---
N
T
P
L
L
Q
E
L
FAK
D
-----
P
-
E
R
A
A
R
R
L
V
H
-
I
P
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
-----
18
PsiBlast_PDB
66.48
35%
-98
- C1 -
4WEC
5
?
A:
[31-269]
------
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
G
D
-
I
D
P
T
T
G
K
A
A
A
D
E
L
------
E
-
G
L
F
-
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
-
S
P
P
E
D
------
D
L
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
--
V
P
A
G
-
K
G
S
I
I
N
T
A
S
F
V
A
V
---
M
-----
G
S
-----
A
---
T
SQ
I
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
G
I
R
V
N
A
L
C
P
G
P
V
---
N
T
P
L
L
Q
E
L
F
A
K
D
-----
P
-
E
R
A
A
R
R
L
V
H
-
I
P
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
-----
35
PsiBlast_CBE
65.75
35%
-97
- C1 -
4WEC
5
?
B:
[31-269]
------
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
G
D
-
I
D
P
T
T
G
K
A
A
A
D
E
L
------
E
-
G
L
F
-
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
-
S
P
P
E
D
------
D
L
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
--
V
P
A
G
-
K
G
S
I
I
N
T
A
S
F
V
A
V
---
M
-----
G
S
-----
A
---
T
SQ
I
S
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
G
I
R
V
N
A
L
C
P
G
P
V
---
N
T
P
L
L
Q
E
L
F
A
K
D
-----
P
-
E
R
A
A
R
R
L
V
H
-
I
P
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
-----
33
PsiBlast_CBE
64.18
35%
-100
- C1 -
4WEC
5
?
D:
[31-269]
------
K
V
A
V
I
T
G
G
A
S
G
I
G
L
A
T
G
R
R
L
R
A
E
G
A
T
V
V
V
G
D
-
I
D
P
T
T
G
K
A
A
A
D
E
L
------
E
-
G
L
F
-
V
P
V
D
V
S
E
Q
E
A
V
D
N
L
F
D
T
A
A
S
T
F
G
R
V
D
I
A
F
N
N
A
G
I
-
S
P
P
E
D
------
D
L
I
E
N
T
D
L
P
A
W
Q
R
V
Q
D
I
N
L
K
S
V
Y
L
S
C
R
A
A
L
R
H
M
--
V
P
A
G
-
K
G
S
I
I
N
T
A
S
F
V
A
V
---
M
-----
G
S
-----
A
---
T
SQIS
Y
T
A
S
K
G
G
V
L
A
M
S
R
E
L
G
V
Q
Y
A
R
Q
G
I
R
V
N
A
L
C
P
G
P
V
---
N
T
P
L
L
Q
E
L
FAK
D
-----
P
-
E
R
A
A
R
R
L
V
H
-
I
P
L
G
R
F
A
E
P
E
E
L
A
A
A
V
A
F
L
A
S
D
D
A
S
F
I
T
G
S
T
F
L
V
D
G
G
-----