@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0778: (2016-04-25 )
MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEHTPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPADDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRGG
Atome Classification :
(46 SA)
.........10........--20-..-.......30.....-...40-.---.--.----....---..50........60........70----......-------..80-..--------..-.-..-----.------90..--....-------.---.100.......110.......120.......130----.....------..---140........150.......160...----....170.......180..-.....190--..-.....-..200..-------.......210...--------....220.......230.......240.......250.......260.......270.......280..-...-..290.....--..-300..-.....310.......320.......330.......340......-.350....-.-.-.360.......370.......380.......-390..--.....400.......410..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTTAAGLSGIDL
T
D
L
D
N
F
A--D--GF-
P
H
H
L
F
A
I
H
RREA
P
V
-
Y
W
HR--P---T--E----HTPD---GEGF
W
S
V
A
T
Y
A
E
T
L
E
V
L
RDPVTYS----SVTGGQ-------RRFG-
G
T
--------
V
L
-
Q
-DL-----P------V
A
G
Q
--
V
L
N
M-------M---DDP
R
H
T
R
I
R
R
L
V
S
SGL
T
P
R
M
I
R
R
V
E
D
D
L
R
R
R
A
R
G
----LLDGV------EP---G-A
P
F
D
F
V
V
E
I
A
A
EL
P
M
Q
M
I
C
I
LLGVP----ETD
R
H
W
L
F
E
AVEPGFDFRG-SRRATM----PR-L
N
V
E
D-AGS--
R
L
-------
Y
T
Y
A
L
E
L
I
AGKRA--------E
P
A
D
D
M
L
S
V
V
ANATIDDPDAPALS
D
A
E
L
Y
L
F
F
H
L
L
F
SAGAE
T
T
R
N
S
IAG
G
L
LALAEN
P
D
Q
L
Q
T
L
R
S
D
F
E
-
L
L
P
-
T
A
I
E
E
I
V
RWT--SP-SPSKR-
R
T
A
S
R
A
VSLGGQPIEAG
Q
K
V
V
V
WEGSANRDPSVFDRADEFDITR-KPNPHLGF-G-
Q
-
G
V
H
Y
C
LGA
N
L
A
R
L
E
L
R
V
L
F
E
E
L
L
S
RFG
S
V
R
V
-V
E
P
A
E
--WTRSNRHTGI
R
H
L
V
V
E
LRGG
9
PsiBlast_PDB
87.07
37%
-92
- C6 -
2WM4
3
CP124_MYCTU
A:
[28-432]
------
I
A
D
I
E
L
G
S
L
D
F
W
A
LD
D
--
D
V
-
R
D
G
A
F
A
T
L
R
R
E
A
P
I
S
F
W
----
P
---
T
--
I
----
E
L
P
G
FVA
G
N
G
H
W
A
L
T
K
Y
D
D
V
F
Y
A
S
R
H
P
D
I
F
S
----
S
Y
P
N
I
--------------
T
--------
I
N
-
D
-
Q
T
-----
P
------
E
L
A
E
--
Y
F
G
S
-------
M
IVL
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
----
L
V
S
S
M
I
A
N
---
N
P
---
D
-
R
Q
A
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
----
K
A
D
H
Q
R
I
F
H
W
T
N
V
I
L
G
F
G
D
-
P
D
L
A
T
D
----
F
D
-
E
F
M
Q
--
V
S
A
--
D
I
-------
G
A
Y
A
T
A
L
A
E
D
R
R
V
--------
N
H
H
D
D
L
T
S
S
L
V
E
A
E
V
D
---
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
L
A
P
-
T
A
V
E
E
I
V
R
W
A
--
S
P
-
V
V
Y
M
R
-
R
T
L
T
Q
D
I
E
L
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
D
P
W
T
F
D
L
A
R
-
N
P
N
P
H
L
G
F
G
G
-
G
-
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
Q
M
P
D
V
V
A
-
T
E
E
P
A
--
R
L
L
S
Q
F
I
H
G
I
K
T
L
P
V
-----
121
HHSearch
86.52
38%
-88
- C6 -
2WM5
1
CP124_MYCTU
A:
[30-434]
--------
D
I
E
L
G
S
L
D
F
W
A
--
L
D
D
D
V
-
R
D
G
A
F
A
T
L
R
R
E
A
P
I
-
S
F
W
P
--
T
---
I
EL-------
V
A
---
G
N
G
H
W
A
L
T
K
Y
D
D
V
F
Y
A
S
R
H
P
D
I
F
S
----
S
Y
P
-
N
I
--------
T
I
N
D
Q
T
-----------
P
-
E
L
-----
A
------
E
Y
F
G
--
S
M
I
V
-------
L
---
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
----
L
V
S
S
M
------
I
A
N
N
P
D
-
R
Q
A
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
----
K
A
D
H
Q
R
I
F
H
W
T
N
V
I
L
G
F
G
D
-
P
D
L
-
A
T
----
D
F
-
D
E
F
M
Q
-
V
S
A
--
D
I
-------
G
A
Y
A
T
A
L
A
E
D
R
R
V
--------
N
H
H
D
D
L
T
S
S
L
V
E
A
E
V
D
G
---
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
L
A
P
-
T
A
V
E
E
I
V
R
W
A
--
S
P
-
V
V
Y
M
R
-
R
T
L
T
Q
D
I
E
L
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
D
P
W
T
F
D
L
A
R
-
N
P
N
P
H
L
G
F
-
G
-
G
G
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
Q
M
P
D
V
V
A
-
T
E
E
P
A
--
R
L
L
S
Q
F
I
H
G
I
K
T
L
P
V
T
W
---
8
PsiBlast_PDB
85.28
35%
-86
- C6 -
2X5L
1
CP125_MYCTU
A:
[23-425]
--------
G
F
D
F
T
D
P
A
I
Y
A
--
E
--
R
L
-
P
V
A
E
F
A
E
L
R
S
A
A
P
I
-
W
W
N
G
--
Q
D
PG
K
--
G
----
G
G
F
H
---
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
----
S
Y
E
N
G
V
I------
P
R
F
K
-
N
D
--------
I
A
R
E
-
D
I
-----
E
------
V
Q
R
F
--
V
M
L
N
-------
M
---
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
----
I
A
A
E
A
------
A
A
---
A
-
G
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
----
Q
E
D
R
G
K
L
F
H
W
S
N
---
E
M
T
G
-
N
E
D
P
E
Y
----
A
H
-
I
D
P
K
A
-
S
S
A
--
E
L
-------
I
G
Y
A
M
K
M
A
E
E
K
A
K
--------
N
P
A
D
D
I
V
T
Q
L
I
Q
A
D
I
---
D
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
W
E
L
Y
K
---
K
-
V
R
P
E
T
A
A
D
E
I
V
R
W
A
--
T
P
-
V
T
A
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
-
N
P
N
P
H
V
G
F
G
G
-
T
-
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
L
K
P
-
I
S
A
P
E
--
R
L
R
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
G
-
1
PsiBlast_PDB
85.14
35%
-86
- C6 -
2X5W
4
CP125_MYCTU
A:
[32-434]
--------
G
F
D
F
T
D
P
A
I
Y
A
--
E
--
R
L
-
P
V
A
E
F
A
E
L
R
S
A
A
P
I
-
W
W
N
G
--
Q
DPG
K
--
G
----
G
G
F
H
---
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
----
S
Y
E
N
G
V
I------
P
R
F
K
-
N
D
--------
I
A
R
E
-
D
I
-----
E
------
V
Q
R
F
--
V
M
L
N
-------
M
---
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
----
I
A
A
E
A
------
A
A
---
A
-
G
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
----
Q
E
D
R
G
K
L
F
H
W
S
N
---
E
M
T
G
-
N
E
D
P
E
Y
----
A
H
-
I
D
P
K
A
-
S
S
A
--
E
L
-------
I
G
Y
A
M
K
M
A
E
E
K
A
K
--------
N
P
A
D
D
I
V
T
Q
L
I
Q
A
D
I
---
D
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
W
E
L
Y
K
---
K
-
V
R
P
E
T
A
A
D
E
I
V
R
W
A
--
T
P
-
V
T
A
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
-
N
P
N
P
H
V
G
F
G
G
-
T
-
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
L
K
P
-
I
S
A
P
E
--
R
L
R
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
G
-
7
PsiBlast_PDB
84.88
35%
-86
- C6 -
2XN8
2
CP125_MYCTU
A:
[15-417]
--------
G
F
D
F
T
D
P
A
I
Y
A
--
E
--
R
L
-
P
V
A
E
F
A
E
L
R
S
A
A
P
I
-
W
W
N
G
--
Q
DPG
K
--
G
----
G
G
F
H
---
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
----
S
Y
E
N
G
V
I------
P
R
F
K
-
N
D
--------
I
A
R
E
-
D
I
-----
E
------
V
Q
R
F
--
V
M
L
N
-------
M
---
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
----
I
A
A
E
A
------
A
A
---
A
-
G
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
----
Q
E
D
R
G
K
L
F
H
W
S
N
---
E
M
T
G
-
N
E
D
P
E
Y
----
A
H
-
I
D
P
K
A
-
S
S
A
--
E
L
-------
I
G
Y
A
M
K
M
A
E
E
K
A
K
----------
A
D
D
I
V
T
Q
L
I
Q
A
D
-----
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
W
E
L
Y
K
---
K
-
V
R
P
E
T
A
A
D
E
I
V
R
W
A
--
T
P
-
V
T
A
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
-
N
P
N
P
H
V
G
F
G
G
-
T
-
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
L
K
P
-
I
S
A
P
E
--
R
L
R
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
G
-
113
HHSearch
84.46
36%
-89
- C6 -
3IVY
1
CP125_MYCTU
A:
[22-427]
-----
L
P
P
G
F
D
F
T
D
P
A
I
Y
A
--
E
--
R
L
-
P
V
A
E
F
A
E
L
R
S
A
A
P
I
-
W
W
N
G
--
Q
---
D
--
P
GKGG
G
F
-
H
---
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
----
S
Y
E
-
N
G
--------
V
I
P
-
R
F
KND-----
I
A
-
R
E
D
I
-----
E
------
V
Q
R
F
--
V
M
L
N
-------
M
---
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
----
I
A
A
E
A
------
A
A
---
A
-
G
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
----
Q
E
D
R
G
K
L
F
H
W
S
N
E
M
T
G
N
E
D
-
P
E
Y
-------
A
H
-
I
D
P
K
A
-
S
S
A
--
E
L
-------
I
G
Y
A
M
K
M
A
E
E
K
---------------
I
V
T
Q
L
I
Q
A
D
--
G
---
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
W
E
-
L
Y
K
K
V
R
--
P
E
-
T
A
A
D
E
I
V
R
W
A
--
T
P
-
V
T
A
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
-
N
P
N
P
H
V
G
F
-
G
G
T
-
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
L
K
P
-
I
S
A
P
E
--
R
L
R
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
G
-
114
HHSearch
83.98
31%
-100
- C6 -
3TKT
1
?
A:
[46-449]
-------------------------
P
-
L
L
D
R
F
D
A
L
R
A
E
A
P
V
-
A
K
V
V
--
A
PDD
E
--------------
H
E
P
F
W
L
V
S
S
F
D
G
V
M
K
A
S
K
D
N
A
T
F
L
----
N
N
P
-
K
S
--------
T
V
F
-
T
L
R
V
G
E
M
M
A
K
A
I
-
T
G
G
S
-----
P
------
H
L
V
E
--
S
L
V
Q
-------
M
---
D
A
P
K
H
P
K
L
R
R
L
T
Q
D
W
F
M
P
K
N
L
A
R
L
D
G
E
I
R
K
I
A
N
E
----
A
I
D
R
M
------
L
G
---
A
G
E
E
G
D
F
M
A
L
V
A
A
P
Y
P
L
H
V
V
M
Q
I
L
G
V
P
----
P
E
D
E
P
K
M
L
F
L
T
Q
Q
M
F
G
G
-------------
Q
I
S
Q
I
V
A
G
-
A
V
A
--
E
F
-------
E
R
Y
F
A
G
L
A
A
E
R
R
R
--------
N
P
T
D
D
V
A
T
V
I
A
N
A
V
V
D
G
---
E
P
M
S
D
R
D
T
A
G
Y
Y
I
I
T
A
S
A
G
H
D
T
T
S
A
S
S
A
G
A
A
L
A
L
A
R
D
P
D
L
F
A
R
V
K
A
D
R
N
-
L
L
P
-
G
I
V
E
E
A
I
R
W
T
--
T
P
-
V
Q
H
F
M
-
R
T
A
A
T
D
T
E
L
C
G
Q
K
I
A
A
G
D
W
L
M
L
N
Y
V
A
A
N
H
D
P
A
Q
F
P
E
P
R
K
F
D
P
T
R
-
P
A
N
R
H
L
A
F
-
G
-
A
-
G
S
H
Q
C
L
G
L
H
L
A
R
L
E
M
R
V
L
L
D
V
L
L
D
R
V
D
S
L
E
L
-
A
G
E
P
K
--
R
V
N
S
T
F
V
G
G
F
K
S
L
P
M
R
W
K
A
-
6
PsiBlast_PDB
83.79
35%
-87
- C6 -
2XC3
2
CP125_MYCTU
A:
[16-418]
--------
G
F
D
F
T
D
P
A
I
Y
A
--
E
--
R
L
-
P
V
A
E
F
A
E
L
R
S
A
A
P
I
-
W
W
N
G
--
Q
DPG
K
--
G
----
G
G
F
H
---
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
----
S
Y
E
N
G
V
I------
P
R
F
K
-
N
D
--------
I
A
R
E
-
D
I
-----
E
------
V
Q
R
F
--
V
M
L
N
-------
M
---
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
----
I
A
A
E
A
------
A
A
---
A
-
G
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
----
Q
E
D
R
G
K
L
F
H
W
S
N
---
E
M
T
G
-
N
E
D
P
E
Y
----
A
H
-
I
D
P
K
A
-
S
S
A
--
E
L
-------
I
G
Y
A
M
K
M
A
E
E
K
A
-------------
D
I
V
T
Q
L
I
Q
A
D
I
---
D
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
W
E
L
Y
K
---
K
-
V
R
P
E
T
A
A
D
E
I
V
R
W
A
--
T
P
-
V
T
A
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
-
N
P
N
P
H
V
G
F
G
G
-
T
-
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
L
K
P
-
I
S
A
P
E
--
R
L
R
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
G
-
10
PsiBlast_PDB
83.68
37%
-91
- C6 -
2WM5
1
CP124_MYCTU
A:
[28-432]
------
I
A
D
I
E
L
G
S
L
D
F
W
A
LD
D
--
D
V
-
R
D
G
A
F
A
T
L
R
R
E
A
P
I
S
F
W
----
P
---
T
--
I
----
E
L
--VA-
G
N
G
H
W
A
L
T
K
Y
D
D
V
F
Y
A
S
R
H
P
D
I
F
S
----
S
Y
P
N
I
--------------
T
--------
I
N
-
D
-
Q
T
-----
P
------
E
L
A
E
--
Y
F
G
S
-------
M
IVL
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
----
L
V
S
S
M
I
A
N
---
N
P
---
D
-
R
Q
A
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
----
K
A
D
H
Q
R
I
F
H
W
T
N
V
I
L
G
F
G
D
-
P
D
L
A
T
D
----
F
D
-
E
F
M
Q
--
V
S
A
--
D
I
-------
G
A
Y
A
T
A
L
A
E
D
R
R
V
--------
N
H
H
D
D
L
T
S
S
L
V
E
A
E
V
D
---
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
L
A
P
-
T
A
V
E
E
I
V
R
W
A
--
S
P
-
V
V
Y
M
R
-
R
T
L
T
Q
D
I
E
L
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
D
P
W
T
F
D
L
A
R
-
N
P
N
P
H
L
G
F
G
G
-
G
-
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
Q
M
P
D
V
V
A
-
T
E
E
P
A
--
R
L
L
S
Q
F
I
H
G
I
K
T
L
P
V
-----
3
PsiBlast_PDB
83.33
35%
-86
- C6 -
3IW0
2
CP125_MYCTU
A:
[25-426]
--------
G
F
D
F
T
D
P
A
I
Y
A
--
E
--
R
L
-
P
V
A
E
F
A
E
L
R
S
A
A
P
I
-
W
W
N
G
--
Q
DPG
K
--
G
----
G
G
F
H
---
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
----
S
Y
E
N
G
V
I------
P
R
F
K
-
N
D
--------
I
A
R
E
-
D
I
-----
E
------
V
Q
R
F
--
V
M
L
N
-------
M
---
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
----
I
A
A
E
A
------
A
A
---
A
-
G
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
----
Q
E
D
R
G
K
L
F
H
W
S
N
---
E
M
T
G
-
N
E
D
P
E
Y
----
A
H
-
I
D
P
K
A
-
S
S
A
--
E
L
-------
I
G
Y
A
M
K
M
A
E
E
K
A
K
--------
N
P
A
D
D
I
V
T
Q
L
I
Q
A
D
I
---
D
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
W
E
L
Y
K
---
K
-
V
R
P
E
T
A
A
D
E
I
V
R
W
A
--
T
P
-
V
T
A
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
-
N
P
N
P
H
V
G
F
G
G
-
T
-
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
L
K
P
-
I
S
A
P
E
--
R
L
R
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
--
5
PsiBlast_PDB
83.11
35%
-90
- C6 -
3IW2
2
CP125_MYCTU
A:
[25-426]
--------
G
F
D
F
T
D
P
A
I
Y
A
--
E
--
R
L
-
P
V
A
E
F
A
E
L
R
S
A
A
P
I
-
W
W
N
G
--
Q
DPG
K
--
G
----
G
G
F
H
---
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
----
S
Y
E
N
G
V
I------
P
R
F
K
-
N
D
--------
I
A
R
E
-
D
I
-----
E
------
V
Q
R
F
--
V
M
L
N
-------
M
---
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
----
I
A
A
E
A
------
A
A
---
A
-
G
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
----
Q
E
D
R
G
K
L
F
H
W
S
N
---
E
M
T
G
-
N
E
D
P
E
Y
----
A
H
-
I
D
P
K
A
-
S
S
A
--
E
L
-------
I
G
Y
A
M
K
M
A
E
E
K
---------------
I
V
T
Q
L
I
Q
A
D
-----
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
W
E
L
Y
K
---
K
-
V
R
P
E
T
A
A
D
E
I
V
R
W
A
--
T
P
-
V
T
A
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
-
N
P
N
P
H
V
G
F
G
G
-
T
-
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
L
K
P
-
I
S
A
P
E
--
R
L
R
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
--
4
PsiBlast_PDB
82.85
35%
-90
- C6 -
3IW1
2
CP125_MYCTU
A:
[25-426]
--------
G
F
D
F
T
D
P
A
I
Y
A
--
E
--
R
L
-
P
V
A
E
F
A
E
L
R
S
A
A
P
I
-
W
W
N
G
--
Q
DPG
K
--
G
----
G
G
F
H
---
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
----
S
Y
E
N
G
V
I------
P
R
F
K
-
N
D
--------
I
A
R
E
-
D
I
-----
E
------
V
Q
R
F
--
V
M
L
N
-------
M
---
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
----
I
A
A
E
A
------
A
A
---
A
-
G
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
----
Q
E
D
R
G
K
L
F
H
W
S
N
---
E
M
T
G
-
N
E
D
P
E
Y
----
A
H
-
I
D
P
K
A
-
S
S
A
--
E
L
-------
I
G
Y
A
M
K
M
A
E
E
K
---------------
I
V
T
Q
L
I
Q
A
D
-----
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
W
E
L
Y
K
---
K
-
V
R
P
E
T
A
A
D
E
I
V
R
W
A
--
T
P
-
V
T
A
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
-
N
P
N
P
H
V
G
F
G
G
-
T
-
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
L
K
P
-
I
S
A
P
E
--
R
L
R
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
--
2
PsiBlast_PDB
82.60
35%
-89
- C6 -
3IVY
1
CP125_MYCTU
A:
[25-427]
--------
G
F
D
F
T
D
P
A
I
Y
A
--
E
--
R
L
-
P
V
A
E
F
A
E
L
R
S
A
A
P
I
-
W
W
N
G
--
Q
DPG
K
--
G
----
G
G
F
H
---
D
G
G
F
W
A
I
T
K
L
N
D
V
K
E
I
S
R
H
S
D
V
F
S
----
S
Y
E
N
G
V
I------
P
R
F
K
-
N
D
--------
I
A
R
E
-
D
I
-----
E
------
V
Q
R
F
--
V
M
L
N
-------
M
---
D
A
P
H
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
V
G
R
L
H
D
E
L
Q
E
R
A
Q
K
----
I
A
A
E
A
------
A
A
---
A
-
G
S
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
G
L
L
G
V
P
----
Q
E
D
R
G
K
L
F
H
W
S
N
---
E
M
T
G
-
N
E
D
P
E
Y
----
A
H
-
I
D
P
K
A
-
S
S
A
--
E
L
-------
I
G
Y
A
M
K
M
A
E
E
K
---------------
I
V
T
Q
L
I
Q
A
D
-----
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
Q
G
M
M
A
F
A
E
H
P
D
Q
W
E
L
Y
K
---
K
-
V
R
P
E
T
A
A
D
E
I
V
R
W
A
--
T
P
-
V
T
A
F
Q
-
R
T
A
L
R
D
Y
E
L
S
G
V
Q
I
K
K
G
Q
R
V
V
M
F
Y
R
S
A
N
F
D
E
E
V
F
Q
D
P
F
T
F
N
I
L
R
-
N
P
N
P
H
V
G
F
G
G
-
T
-
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
V
A
D
H
M
P
D
L
K
P
-
I
S
A
P
E
--
R
L
R
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
G
-
91
PsiBlast_CBE
82.38
35%
-87
- C6 -
2WI9
2
PIKC_STRVZ
A:
[32-427]
------
P
P
V
L
D
L
G
A
L
G
Q
D
F
--
A
--
A
D
-
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
-
H
R
V
R
---------------
T
P
E
---
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
-
R
F
S
----
K
----
D
-------
W
R
N
S
-
T
T
--------
P
L
-
T
-
E
A
-----
E
------
A
A
L
N
---
H
N
M
-------
L
ES-
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
---
M
R
R
V
E
L
-
L
R
P
R
V
Q
E
----
I
V
D
G
L
V
D
A
M
L
A
A
P
---
D
-
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
----
E
P
D
R
A
-
A
F
R
V
W
T
D
A
F
V
F
P
D
-
D
P
-----------
A
Q
A
Q
T
-
A
M
A
--
E
M
-------
S
G
Y
L
S
R
L
I
D
S
K
R
G
--------
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
--
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
--
G
P
-
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
G
H
L
A
F
-
G
-
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
LV
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
R
R
-
17
PsiBlast_PDB
82.26
31%
-103
- C6 -
1CPT
1
CPXL_PSESP
A:
[44-425]
------------------------------------------------------------
H
I
E
G
---
Y
D
P
M
W
I
A
T
K
H
A
D
V
M
Q
I
G
K
Q
P
G
L
F
S
----
N
A
E
G
S
E
ILYD
Q
N
N
E
A
F
M
-
R
S
--------
I
S
-
G
-
G
C
-----
P
------
H
V
I
D
--
S
L
T
S
-------
M
---
D
P
P
T
H
T
A
Y
R
G
L
T
L
N
W
F
Q
P
A
S
I
R
K
L
E
E
N
I
R
R
I
A
Q
A
S
V
Q
R
L
L
D
F
------------
D
-
G
E
C
D
F
M
T
D
C
A
L
Y
Y
P
L
H
V
V
M
T
A
L
G
V
P
----
E
D
D
E
P
L
M
L
K
L
T
Q
---
D
F
F
G
V-----------------
E
-
A
A
R
--
R
F
H
E
T
I
A
T
F
Y
D
Y
F
N
G
F
T
V
D
R
R
S
--------
C
P
K
D
D
V
M
S
L
L
A
N
S
K
L
D
---
G
N
Y
I
D
D
K
Y
I
N
A
Y
Y
V
A
I
A
T
A
G
H
D
T
T
S
S
S
S
G
G
A
I
I
G
L
S
R
N
P
E
Q
L
A
L
A
K
S
D
P
A
-
L
I
P
-
R
L
V
D
E
A
V
R
W
T
--
A
P
-
V
K
S
F
M
-
R
T
A
L
A
D
T
E
V
R
G
Q
N
I
K
R
G
D
R
I
M
L
S
Y
P
S
A
N
R
D
E
E
V
F
S
N
P
D
E
F
D
I
T
R
-
F
P
N
R
H
L
G
F
-
G
-
W
-
G
A
H
M
C
L
G
Q
H
L
A
K
L
E
M
K
I
F
F
E
E
L
L
P
K
L
K
S
V
E
L
-
S
G
P
P
R
--
L
V
A
T
N
F
V
G
G
P
K
N
V
P
I
R
F
---
12
PsiBlast_PDB
81.88
35%
-84
- C6 -
4APY
12
?
A:
[2-411]
-
P
T
P
N
I
P
S
D
F
D
F
L
D
A
T
L
N
L
--
E
--
R
L
-
P
V
E
E
L
A
E
L
R
K
S
E
P
I
-
H
W
V
D
VP
G
---
G
--
T
----
G
G
F
G
---
D
K
G
Y
W
L
V
T
K
H
A
D
V
K
E
V
S
R
R
S
D
V
F
G
----
S
S
P
D
G
A
-------
I
P
V
W
-
P
Q
--------
D
M
-
T
-
R
E
-----
A
------
V
D
L
Q
RA
V
L
L
N
-------
M
---
D
A
P
Q
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
I
G
R
L
E
D
E
L
R
S
R
A
Q
K
----
I
A
Q
T
A
------
A
A
---
Q
-
G
A
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
E
L
L
G
V
P
----
Q
D
D
R
D
K
L
---------
F
R
W
-
S
N
E
M
T
A
GEDP
E
Y
-
A
D
V
D
P
-
A
M
S
S
F
E
L
-------
I
S
Y
A
M
K
M
A
E
E
R
A
V
--------
N
P
T
E
D
I
V
T
K
L
I
E
A
D
I
---
D
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
H
G
M
I
A
F
A
Q
N
P
D
Q
W
E
L
Y
K
K
--
E
-
R
P
E
-
T
A
A
D
E
I
V
R
W
A
--
T
P
-
V
S
A
F
Q
-
R
T
A
L
E
D
V
E
L
G
G
V
Q
I
K
K
G
Q
R
V
V
M
S
Y
R
S
A
N
F
D
E
E
V
F
E
D
P
H
T
F
N
I
L
R
-
S
P
N
P
H
V
G
F
G
G
-
T
-
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
I
A
D
N
M
P
D
L
K
P
-
I
G
A
P
E
--
R
L
K
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
G
A
20
PsiBlast_PDB
81.46
30%
-102
- C6 -
4L0E
3
?
A:
[35-429]
------
I
S
T
I
N
L
T
D
P
R
T
Y
E
--
V
--
N
D
-
L
S
E
Y
W
R
Q
L
R
T
T
R
P
L
-
Y
W
H
P
--
P
---
V
--
G
----
D
A
P
------
G
F
W
V
V
S
R
Y
A
D
V
M
A
L
Y
K
D
N
K
K
L
T
----
S
E
K
G
N
-----------------------
V
L
-
V
-
T
L
L
A
GGD
S
------
A
A
G
K
--
M
L
A
V
-------
T
---
D
G
A
M
H
R
G
L
R
N
V
L
L
K
S
F
S
P
Q
A
L
K
P
I
V
D
Q
I
R
V
N
T
T
R
----
L
V
V
D
A
------
A
R
---
R
-
G
E
C
D
F
A
A
D
V
A
E
Q
I
P
L
N
T
I
S
D
L
L
G
V
P
----
A
A
D
R
E
F
L
L
K
L
N
K
S
A
L
---
S
-
S
E
--
D
Q
----
S
A
-
T
D
A
W
L
-
A
R
N
--
E
I
-------
L
L
Y
F
S
E
L
V
A
E
R
R
A
--------
K
P
T
E
D
V
I
S
V
L
A
N
S
M
V
D
---
G
K
P
L
T
E
E
V
I
V
L
N
C
Y
S
L
I
L
G
G
D
E
T
S
R
L
S
M
I
D
S
V
Q
T
F
T
Q
Y
P
D
Q
W
E
L
L
R
D
G
K
V
-
T
L
E
-
S
A
T
E
E
V
L
R
W
A
--
T
P
-
A
M
H
F
G
-
R
R
A
V
T
D
M
E
L
H
G
Q
V
I
A
A
G
D
V
V
T
L
W
N
N
S
A
N
R
D
E
E
V
F
A
D
P
Y
A
F
D
L
N
R
-
S
P
N
K
H
I
T
F
-
G
-
Y
-
G
P
H
F
C
L
G
A
Y
L
G
R
A
E
V
H
A
L
L
D
A
L
R
T
Y
T
T
G
F
E
I
-
T
G
E
P
Q
--
R
I
H
S
N
F
L
T
G
L
S
R
L
P
V
R
I
Q
--
18
PsiBlast_PDB
81.26
32%
-90
- C6 -
3RWL
1
?
A:
[24-424]
------
L
D
S
I
D
V
S
I
P
E
L
F
Y
--
N
--
D
S
-
V
G
E
Y
F
K
R
L
R
K
D
D
P
V
-
H
Y
C
A
--
D
---
S
--
A
----
F
G
P
-------
Y
W
S
I
T
K
Y
N
D
I
M
H
V
D
T
N
H
D
I
F
S
----
S
D
A
G
-----------
Y
G
-
G
I
--------
I
I
-
D
-
D
G
-----
I
---------------
L
DLPNFIA
M
---
D
R
P
R
H
D
E
Q
R
K
A
V
S
P
I
V
A
P
A
N
L
A
A
L
E
G
T
I
R
E
R
V
S
K
----
T
L
D
G
L
------
P
V
---
G
-
E
E
F
D
W
V
D
R
V
S
I
E
I
T
T
Q
M
L
A
T
L
F
D
F
P
----
F
E
E
R
R
K
L
T
---------
R
W
-
S
D
V
T
T
A
A---
P
G
-
G
G
V
V
E
-
S
W
D
--
Q
R
-------
K
T
E
L
L
E
C
A
A
Y
F
Q
V
L
W
N
E
R
V
NK
D
P
G
N
D
L
I
S
M
L
A
H
S
----
P
A
T
R
N
M
T
P
E
E
Y
L
G
N
V
L
L
L
I
V
G
G
N
D
T
T
R
N
S
M
T
G
G
V
L
A
L
H
K
N
P
D
Q
F
A
K
L
K
A
N
P
A
-
L
V
E
-
T
M
V
P
E
I
I
R
W
Q
--
T
P
-
L
A
H
M
R
-
R
T
A
I
A
D
S
E
L
G
G
K
T
I
R
K
G
D
K
V
V
M
W
Y
Y
S
G
N
R
D
D
E
V
I
D
R
P
E
E
F
I
I
D
R
P
R
P
R
Q
H
L
S
F
-
G
-
F
-
G
I
H
R
C
V
G
N
R
L
A
E
M
Q
L
R
I
L
W
E
E
I
L
T
R
F
S
R
I
E
V
-
M
A
E
P
E
--
R
V
R
S
N
F
V
R
G
Y
A
K
M
M
V
R
V
---
93
PsiBlast_CBE
81.09
35%
-86
- C6 -
2WHW
2
PIKC_STRVZ
A:
[32-427]
------
P
P
V
L
D
L
G
A
L
G
Q
D
F
--
A
--
A
D
-
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
-
H
R
V
R
---------------
T
P
E
---
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
-
R
F
S
----
K
----
D
-------
W
R
N
S
-
T
T
--------
P
L
-
T
-
E
A
-----
E
------
A
A
L
N
---
H
N
M
-------
L
ES-
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
---
M
R
R
V
E
L
-
L
R
P
R
V
Q
E
----
I
V
D
G
L
V
D
A
M
L
A
A
P
---
D
-
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
----
E
P
D
R
A
-
A
F
R
V
W
T
D
A
F
V
F
P
D
-
D
P
-----------
A
Q
A
Q
T
-
A
M
A
--
E
M
-------
S
G
Y
L
S
R
L
I
D
S
K
R
G
--------
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
--
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
--
G
P
-
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
G
H
L
A
F
-
G
-
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
R
R
-
21
PsiBlast_CBE
81.04
34%
-93
- C6 -
4TRI
3
?
B:
[2-373]
-
T
Q
M
L
T
R
P
D
V
D
L
V
N
G
M
F
Y
A
--
D
--
G
G
-
A
R
E
A
Y
R
W
M
R
A
N
E
P
V
-
F
R
D
R
----------------------
N
G
L
A
A
A
T
T
Y
Q
A
V
L
D
A
E
R
N
P
E
L
F
S
----
S
-
T
G
G
I
-------
R
-----------------
P
-
D
Q
-----
P
------
G
M
P
Y
--
M
I
D
M
-----------
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
L
C
D
T
----
L
I
D
A
V
------
C
E
---
R
-
G
E
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
----
P
T
E
R
D
M
L
L
K
W
S
D
D
L
V
C
G
L
S
-
S
H
V
D
E
A
----
A
I
-
Q
K
L
M
D
-
T
F
A
--
A
Y
-------
T
E
F
T
K
D
V
I
T
K
R
R
A
--------
E
P
T
D
D
L
F
S
V
L
V
N
S
E
V
E
---
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
-
L
L
P
-
G
A
I
E
E
M
L
R
W
T
--
S
P
-
V
K
N
M
C
-
R
T
L
T
A
D
T
V
F
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
-
N
P
N
S
H
V
A
F
-
G
-
F
-
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
-
A
D
D
A
-----------------------
92
PsiBlast_CBE
80.73
35%
-86
- C6 -
2WHW
4
PIKC_STRVZ
B:
[34-426]
--------
V
L
D
L
G
A
L
G
Q
D
F
--
A
--
A
D
-
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
-
H
R
V
R
---------------
T
P
E
---
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
-
R
F
S
----
K
----
D
-------
W
R
N
S
-
T
T
--------
P
L
-
T
-
E
A
-----
E
------
A
A
L
N
---
H
N
M
-------
L
ES-
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
---
M
R
R
V
E
L
-
L
R
P
R
V
Q
E
----
I
V
D
G
L
V
D
A
M
L
A
A
P
---
D
-
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
----
E
P
D
R
A
-
A
F
R
V
W
T
D
A
F
V
F
P
D
-
D
P
-----------
A
Q
A
Q
T
-
A
M
A
--
E
M
-------
S
G
Y
L
S
R
L
I
D
S
K
R
G
--------
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
--
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
--
G
P
-
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
G
H
L
A
F
-
G
-
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
R
--
78
PsiBlast_CBE
80.35
35%
-85
- C6 -
4B7D
3
PIKC_STRVZ
A:
[34-426]
--------
V
L
D
L
G
A
L
G
Q
D
F
--
A
--
A
D
-
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
-
H
R
V
R
---------------
T
P
E
---
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
-
R
F
S
----
K
----
D
-------
W
R
N
S
-
T
T
--------
P
L
-
T
-
E
A
-----
E
------
A
A
L
N
---
H
N
M
-------
L
ES-
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
---
M
R
R
V
E
L
-
L
R
P
R
V
Q
E
----
I
V
D
G
L
V
D
A
M
L
A
A
P
---
D
-
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
----
E
P
D
R
A
-
A
F
R
V
W
T
D
A
F
V
F
P
D
-
D
P
-----------
A
Q
A
Q
T
-
A
M
A
--
E
M
-------
S
G
Y
L
S
R
L
I
D
S
K
R
G
--------
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
--
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
--
G
P
-
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
G
H
L
A
F
-
G
-
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
R
--
96
PsiBlast_CBE
80.26
35%
-85
- C6 -
4UMZ
2
PIKC_STRVZ
A:
[32-427]
------
P
P
V
L
D
L
G
A
L
G
Q
D
F
--
A
--
A
D
-
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
-
H
R
V
R
---------------
T
P
E
---
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
-
R
F
S
----
K
----
D
-------
W
R
N
S
-
T
T
--------
P
L
-
T
-
E
A
-----
E
------
A
A
L
N
---
H
N
M
-------
L
ES-
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
---
M
R
R
V
E
L
-
L
R
P
R
V
Q
E
----
I
V
D
G
L
V
D
A
M
L
A
A
P
---
D
-
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
----
E
P
D
R
A
-
A
F
R
V
W
T
D
A
F
V
F
P
D
-
D
P
-----------
A
Q
A
Q
T
-
A
M
A
--
E
M
-------
S
G
Y
L
S
R
L
I
D
S
K
R
G
--------
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
--
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
--
G
P
-
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
G
H
L
A
F
-
G
-
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
R
R
-
90
PsiBlast_CBE
79.78
35%
-84
- C6 -
2WI9
5
PIKC_STRVZ
B:
[34-427]
--------
V
L
D
L
G
A
L
G
Q
D
F
--
A
--
A
D
-
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
-
H
R
V
R
---------------
T
P
E
---
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
-
R
F
S
----
K
----
D
-------
W
R
N
S
-
T
T
--------
P
L
-
T
-
E
A
-----
E
------
A
A
L
N
---
H
N
M
-------
L
ES-
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
---
M
R
R
V
E
L
-
L
R
P
R
V
Q
E
----
I
V
D
G
L
V
D
A
M
L
A
A
P
---
D
-
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
----
E
P
D
R
A
-
A
F
R
V
W
T
D
A
F
V
F
P
D
-
D
P
-----------
A
Q
A
Q
T
-
A
M
A
--
E
M
-------
S
G
Y
L
S
R
L
I
D
S
K
R
G
--------
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
--
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
--
G
P
-
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
G
H
L
A
F
-
G
-
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
LV
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
R
R
-
11
PsiBlast_PDB
79.77
35%
-82
- C6 -
5DQN
4
?
A:
[2-411]
-
P
T
P
N
I
P
S
D
F
D
F
L
D
A
T
L
N
L
--
E
--
R
L
-
P
V
E
E
L
A
E
L
R
K
S
E
P
I
-
H
W
V
D
VP
G
---
G
--
T
----
G
G
F
G
---
D
K
G
Y
W
L
V
T
K
H
A
D
V
K
E
V
S
R
R
S
D
V
F
G
----
S
S
P
D
G
A
-------
I
P
V
Y
-
P
Q
--------
D
M
-
T
-
R
E
-----
A
------
V
D
L
Q
RA
V
L
L
N
-------
M
---
D
A
P
Q
H
T
R
L
R
K
I
I
S
R
G
F
T
P
R
A
I
G
R
L
E
D
E
L
R
S
R
A
Q
K
----
I
A
Q
T
A
------
A
A
---
Q
-
G
A
G
D
F
V
E
Q
V
S
C
E
L
P
L
Q
A
I
A
E
L
L
G
V
P
----
Q
D
D
R
D
K
L
---------
F
R
W
-
S
N
E
M
T
A
GEDP
E
Y
-
A
D
V
D
P
-
A
M
S
S
F
E
L
-------
I
S
Y
A
M
K
M
A
E
E
R
A
V
--------
N
P
T
E
D
I
V
T
K
L
I
E
A
D
I
---
D
G
E
K
L
S
D
D
E
F
G
F
F
V
V
M
L
A
V
A
G
N
E
T
T
R
N
S
I
T
H
G
M
I
A
F
A
Q
N
P
D
Q
W
E
L
Y
K
K
--
E
-
R
P
E
-
T
A
A
D
E
I
V
R
W
A
--
T
P
-
V
S
A
F
Q
-
R
T
A
L
E
D
V
E
L
G
G
V
Q
I
K
K
G
Q
R
V
V
M
S
Y
R
S
A
N
F
D
E
E
V
F
E
D
P
H
T
F
N
I
L
R
-
S
P
N
P
H
V
G
F
G
G
-
T
-
G
A
H
Y
C
I
G
A
N
L
A
R
M
T
I
N
L
I
F
N
A
I
A
D
N
M
P
D
L
K
P
-
I
G
A
P
E
--
R
L
K
S
G
W
L
N
G
I
K
H
W
Q
V
D
Y
T
G
A
95
PsiBlast_CBE
79.72
35%
-87
- C6 -
4UMZ
2
PIKC_STRVZ
B:
[33-427]
-------
P
V
L
D
L
G
A
L
G
Q
D
F
--
A
--
A
D
-
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
-
H
R
V
R
---------------
T
P
E
---
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
-
R
F
S
----
K
----
D
-------
W
R
N
S
-
T
T
--------
P
L
-
T
-
E
A
-----
E
------
A
A
L
N
---
H
N
M
-------
L
ES-
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
---
M
R
R
V
E
L
-
L
R
P
R
V
Q
E
----
I
V
D
G
L
V
D
A
M
L
A
A
P
---
D
-
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
----
E
P
D
R
A
-
A
F
R
V
W
T
D
A
F
V
F
P
D
-
D
P
-----------
A
Q
A
Q
T
-
A
M
A
--
E
M
-------
S
G
Y
L
S
R
L
I
D
S
K
R
G
--------
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
--
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
--
G
P
-
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
G
H
L
A
F
-
G
-
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
R
R
-
77
PsiBlast_CBE
79.57
35%
-86
* C6 *
4B7D
4
PIKC_STRVZ
B:
[34-426]
--------
V
L
D
L
G
A
L
G
Q
D
F
--
A
--
A
D
-
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
-
H
R
V
R
---------------
T
P
E
---
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
-
R
F
S
----
K
----
D
-------
W
R
N
S
-
T
T
--------
P
L
-
T
-
E
A
-----
E
------
A
A
L
N
---
H
N
M
-------
L
ES-
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
---
M
R
R
V
E
L
-
L
R
P
R
V
Q
E
----
I
V
D
G
L
VDAMLA
A
P
---
D
-
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
----
E
P
D
R
A
-
A
F
R
V
W
T
D
A
F
V
F
P
D
-
D
P
-----------
A
Q
A
Q
T
-
A
M
A
--
E
M
-------
S
G
Y
L
S
R
L
I
D
S
K
R
G
--------
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
--
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
--
G
P
-
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
G
H
L
A
F
-
G
-
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
LV
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
R
--
82
PsiBlast_CBE
79.34
35%
-85
- C6 -
2CA0
2
PIKC_STRVZ
A:
[34-426]
--------
V
L
D
L
G
A
L
G
Q
D
F
--
A
--
A
D
-
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
-
H
R
V
R
---------------
T
P
E
---
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
-
R
F
S
----
K
----
D
-------
W
R
N
S
-
T
T
--------
P
L
-
T
-
E
A
-----
E
------
A
A
L
N
---
H
N
M
-------
L
ES-
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
---
M
R
R
V
E
L
-
L
R
P
R
V
Q
E
----
I
V
D
G
L
V
D
A
M
L
A
A
P
---
D
-
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
----
E
P
D
R
A
-
A
F
R
V
W
T
D
A
F
V
F
P
D
-
D
P
-----------
A
Q
A
Q
T
-
A
M
A
--
E
M
-------
S
G
Y
L
S
R
L
I
D
S
K
R
G
--------
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
--
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
--
G
P
-
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
G
H
L
A
F
-
G
-
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
R
--
81
PsiBlast_CBE
76.21
35%
-80
- C6 -
2CA0
2
PIKC_STRVZ
B:
[34-426]
--------
V
L
D
L
G
A
L
G
Q
D
F
--
A
--
A
D
-
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
-
H
R
V
R
---------------
T
P
E
---
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
-
R
F
S
----
K
----
D
-------
W
R
N
S
-
T
T
--------
P
L
-
T
-
E
A
-----
E
------
A
A
L
N
---
H
N
M
-------
L
ES-
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
---
M
R
R
V
E
L
-
L
R
P
R
V
Q
E
----
I
V
D
G
L
VDAMLA
A
P
---
D
-
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
----
E
P
D
R
A
-
A
F
R
V
W
T
D
A
F
V
F
P
D
-
D
P
-----------
A
Q
A
Q
T
-
A
M
A
--
E
M
-------
S
G
Y
L
S
R
L
I
D
S
K
R
G
--------
Q
D
G
E
D
L
L
S
A
L
V
R
T
S
--
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
-
L
L
D
-
G
A
V
E
E
M
L
R
Y
E
--
G
P
-
V
E
S
A
T
Y
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
G
H
L
A
F
-
G
-
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
LV
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
R
--
19
PsiBlast_PDB
76.00
33%
-97
- C6 -
4RM4
1
YJIB_BACSU
A:
[22-376]
---------------------
D
--
A
Y
H
P
F
P
W
Y
E
S
M
R
K
D
A
P
V
-
S
F
D
E
--
E
---
N
--
Q
--------------
V
W
S
V
F
L
Y
D
D
V
K
K
V
V
G
D
K
E
L
F
S
----
S
C
M
---------------------------------------------
G
N
S
--
I
I
N
M
-----------
D
P
P
K
H
T
K
I
R
S
V
V
N
K
A
F
T
P
R
V
M
K
Q
W
E
P
R
I
Q
E
I
T
D
E
----
L
I
Q
K
F
------
Q
G
---
R
-
S
E
F
D
L
V
H
D
F
S
Y
P
L
P
V
I
V
I
S
E
L
L
G
V
P
SAH
M
E
Q
F
K
A
W
S
D
L
L
V
S
T
P
K
D
--
K
-
S
E
E
A
E
K
----
A
F
-
L
E
E
R
D
K
C
E
E
--
E
L
-------
A
A
F
F
A
G
I
I
E
E
K
R
N
--------
K
P
E
Q
D
I
I
S
I
L
V
E
-------
G
E
K
L
S
G
E
E
L
I
P
F
C
T
L
L
L
V
A
G
N
E
T
T
T
N
L
I
S
N
A
M
Y
S
I
L
E
T
P
G
V
Y
E
E
L
R
S
H
P
E
-
L
M
P
-
Q
A
V
E
E
A
L
R
F
R
--
A
P
-
A
P
V
L
R
-
R
I
A
K
R
D
T
E
I
G
G
H
L
I
K
E
G
D
M
V
L
A
F
V
A
S
A
N
R
D
E
A
K
F
D
R
P
H
M
F
D
I
R
R
-
H
P
N
P
H
I
A
F
-
G
-
H
-
G
I
H
F
C
L
G
A
P
L
A
R
L
E
A
N
I
A
L
T
S
L
I
S
A
F
P
H
M
E
C
-
V
--------------------------
53
PsiBlast_CBE
75.29
36%
-96
- C6 -
2Y5Z
7
MYCG_MICGR
B:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRPEM
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T
--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
-----
L
S
T
A
E
V
----
T
A
-
E
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
F
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
57
PsiBlast_CBE
74.96
36%
-94
- C6 -
2Y46
5
MYCG_MICGR
C:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRPEM
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
-----
L
S
T
A
E
V
----
T
A
-
E
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
F
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
55
PsiBlast_CBE
74.52
36%
-95
- C6 -
2Y5N
7
MYCG_MICGR
B:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRP
E
M
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T
--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
-----
L
S
T
A
E
V
----
T
A
-
E
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
F
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
51
PsiBlast_CBE
74.52
36%
-95
- C6 -
2Y98
7
MYCG_MICGR
A:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRP
E
M
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T
--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
-----
L
S
T
A
E
V
----
T
A
-
E
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
F
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
59
PsiBlast_CBE
74.34
36%
-94
- C6 -
2Y46
6
MYCG_MICGR
A:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRP
E
M
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T
--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
-----
L
S
T
A
E
V
----
T
A
-
E
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
F
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
58
PsiBlast_CBE
74.00
36%
-94
- C6 -
2Y46
5
MYCG_MICGR
B:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRPEM
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
-----
L
S
T
A
E
V
----
T
A
-
E
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
F
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
56
PsiBlast_CBE
73.84
36%
-94
- C6 -
2Y5N
9
MYCG_MICGR
A:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRP
E
M
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T
--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
-----
L
S
T
A
E
V
----
T
A
-
E
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
F
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
52
PsiBlast_CBE
73.79
36%
-94
- C6 -
2Y5Z
6
MYCG_MICGR
C:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRPEM
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
-----
L
S
T
A
E
V
----
T
A
-
E
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
F
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
61
PsiBlast_CBE
73.24
35%
-95
- C6 -
3A4G
2
CPVDH_PSEAH
A:
[22-366]
---------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
-
R
---------
K
--
L
----
A
L
P
D
---
G
P
-
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
DWRH
T
L
P
E
D
Q
-------
R
-----------------
A
-
D
M
-----
P
------
A
T
P
T
P-
M
M
I
L
-------
M
---
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
----
L
L
A
G
L
------
P
T
---
D
-
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
----
A
E
D
R
D
----------
D
F
S
A
-
W
S
S
V
L
V
DDS-
P
A
-
D
D
K
N
A
-
A
M
G
--
K
L
-------
H
G
Y
L
S
D
L
L
E
R
K
R
T
--------
E
P
D
D
A
L
L
S
S
L
--
L
A
V
S
D
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
-
L
I
S
-
S
A
V
E
E
F
L
R
F
D
--
S
P
V
S
Q
A
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
G
G
V
F
F
-
G
-
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
-----------------------------------
45
PsiBlast_CBE
73.12
36%
-91
- C6 -
4AW3
8
MYCG_MICGR
A:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRP
E
M
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T
--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
-
E
V
T
A
E
---------
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
V
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
54
PsiBlast_CBE
72.92
36%
-92
- C6 -
2Y5Z
8
MYCG_MICGR
A:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRPEM
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T
--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
-----
L
S
T
A
E
V
----
T
A
-
E
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
F
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
44
PsiBlast_CBE
72.73
36%
-91
- C6 -
4AW3
8
MYCG_MICGR
B:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRPEM
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
-
E
V
T
A
E
---------
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
V
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
41
PsiBlast_CBE
71.03
36%
-90
- C6 -
3ZSN
6
MYCG_MICGR
C:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRPEM
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
-
E
V
T
A
E
---------
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
A
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
42
PsiBlast_CBE
70.72
36%
-90
- C6 -
3ZSN
6
MYCG_MICGR
B:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRPEM
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
-
E
V
T
A
E
---------
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
A
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
43
PsiBlast_CBE
70.01
36%
-90
- C6 -
3ZSN
7
MYCG_MICGR
A:
[51-400]
---------------------------------------
P
V
-
S
R
V
R
--
P
-------------
P
Y
---
G
E
E
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
-------------
G
R
-------
F
V
R
G
-
P
S
--------
M
T
-
R
-
D
E
-----
P
RTRP
E
M
V
K
G
G
--
L
L
S
M
-----------
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
----
L
V
D
Q
M
------
A
A
T
--
G
-
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
----
S
A
D
-
H
D
R
F
T
R
W
S
G
A
F
L
S
T
A
-
E
V
T
A
E
---------
E
M
Q
E
-
A
A
E
--
Q
A
-------
Y
A
Y
M
G
D
L
I
D
R
R
R
K
--------
E
P
T
D
D
L
V
S
A
L
V
Q
A
R
-
D
Q
Q
D
S
--
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
-
L
I
P
-
S
A
V
E
E
L
T
R
W
V
PL
G
V
-
G
T
A
A
P
-
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
Q
H
L
G
F
-
G
-
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
-
G
I
P
E
T
--
Q
L
R
-----------------
94
PsiBlast_CBE
69.54
34%
-90
- C6 -
3VRM
2
CPVDH_PSEAH
A:
[22-366]
---------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
-
R
---------
K
--
L
----
A
L
P
D
---
G
P
-
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
DWRH
T
L
P
E
D
Q
-------
R
-----------------
A
-
D
M
-----
P
------
A
T
P
T
P-
M
M
I
L
-------
M
---
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
A
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
----
L
L
A
G
L
------
P
T
---
D
-
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
----
A
E
D
R
D
----------
D
F
S
A
-
W
S
S
V
L
V
D
DS-
P
A
-
D
D
K
N
A
-
A
M
G
--
K
L
-------
H
G
Y
L
S
D
L
L
E
R
K
R
T
--------
E
P
D
D
A
L
L
S
S
L
--
L
A
V
S
D
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
-
L
I
S
-
S
A
V
E
E
F
L
R
F
D
--
S
P
V
S
Q
A
P
I
-
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
G
G
V
F
F
-
G
-
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
-----------------------------------