@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0799c: (2016-04-26 )
MAVPAVSPQPILAPLTPAAIFLVATIGADGEATVHDALSKISGLVRAIGFRDPTKHLSVVVSIGSDAWDRLFAGPRPTELHPFVELTGPRHTAPATPGDLLFHIRAETMDVCFELAGRILKSMGDAVTVVDEVHGFRFFDNRDLLGFVDGTENPSGPIAIKATTIGDEDRNFAGSCYVHVQKYVHDMASWESLSVTEQERVIGRTKLDDIELDDNAKPANSHVALNVITDDDGTERKIVRHNMPFGEVGKGEYGTYFIGYSRTPTVTEQMLRNMFLGDPAGNTDRVLDFSTAVTGGLFFSPTIDFLDHPPPLPQAATPTLAAGSLSIGSLKGSPR
Atome Classification :
(38 SA)
.........10.-.......20.....--..--.--30........40........50-..-......60........70....-....80........90........100.......110.......120.......130.......140.......150...---...-.160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300....----...310.......320.......330...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAVPAVSPQPIL-APLTP
A
A
I
F
L
V
A
T
I--GA--D--G
E
A
T
V
H
D
A
L
S
K
I
S
G
L
V
R
A
IGFR-DP-TK
H
L
S
V
V
V
S
IG
S
D
A
W
D
R
LFAGP-RPTE
L
H
P
F
V
E
LTGPRHTAPATPG
D
L
L
F
H
I
R
A
E
T
M
D
V
C
F
E
L
A
G
R
I
L
K
SMG
D
A
V
T
V
V
DEVH
G
F
R
F
FDNRD
L
L
G
F
VDGTENPS---G
P
I
-
A
I
K
A
T
TIGDEDRNFA
G
S
C
Y
V
H
V
Q
K
Y
V
H
D
M
ASWESLS
V
T
E
Q
E
R
VIGRTKLD
D
I
ELDDNAKPAN
S
H
V
A
L
N
V
I
TDDDGTE
R
K
I
V
RHNMPFGEVGKGEYG
T
Y
F
IGYSRT
P
T
V
T
E
Q
M
L
R
N
MFLGDPAGNT
D
R
V
L
D
F
STAVTG
G
L
F
FSPT
I
D
FL----DHPPPLPQAATPTLAAGS
L
S
I
GSLKGSPR
2
PsiBlast_PDB
96.58
56%
-102
- C3 -
3QNS
8
?
A:
[8-318]
--
V
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
S
D
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
E
S
LG
D
----------------------------
35
PsiBlast_CBE
96.54
60%
-98
- C3 -
4GU7
2
?
D:
[30-336]
-------
P
Q
M
V
L
-
S
P
L
T
S
A
A
I
F
L
V
V
T
I
--
D
S
--
G
--
G
E
D
T
V
R
D
L
L
S
D
V
A
S
L
E
R
A
V
G
F
R
A
Q
P
-
D
G
R
L
S
C
V
T
G
I
G
S
E
A
W
D
R
L
F
S
G
A
-
R
P
A
G
L
H
P
F
R
E
L
D
G
P
V
H
R
A
V
A
T
P
G
D
L
L
F
H
I
R
A
S
R
L
D
L
C
F
A
L
A
T
E
I
M
G
R
L
R
G
A
V
T
P
Q
D
E
V
H
G
F
K
Y
F
D
E
R
D
M
L
G
F
V
D
G
T
E
N
P
T
---
G
A
A
-
A
R
R
A
V
L
V
G
A
E
D
P
A
F
A
G
G
S
Y
A
V
V
Q
K
Y
L
H
D
I
D
A
W
E
G
L
S
V
E
A
Q
E
R
V
I
G
R
R
K
M
T
D
V
E
L
S
D
D
V
K
P
A
D
S
H
V
A
L
T
S
V
T
G
P
D
G
S
D
L
E
I
L
R
D
N
M
P
F
G
S
V
G
R
E
E
F
G
T
Y
F
I
G
Y
A
R
T
P
E
V
T
E
T
M
L
E
R
M
F
L
G
T
A
S
A
P
H
D
R
I
L
D
F
S
T
A
V
T
G
S
L
F
F
T
P
A
A
D
F
L
----
E
D
L
P
A
R
P
----------------------
56
Fugue
96.49
58%
-99
* C3 *
3QNS
8
?
A:
[8-318]
--
V
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
G
D
S
D
--
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
----
E
S
L
G
D
------------------------
43
HHSearch
96.26
60%
-94
- C3 -
4GU7
1
?
A:
[27-336]
----
E
P
E
P
Q
M
V
L
-
S
P
L
T
S
A
A
I
F
L
V
V
T
I
--
D
S
--
G
--
G
E
D
T
V
R
D
L
L
S
D
V
A
S
L
E
R
A
V
G
F
R
-
A
Q
P
D
G
R
L
S
C
V
T
G
I
G
S
E
A
W
D
R
L
F
S
G
A
-
R
P
A
G
L
H
P
F
R
E
L
D
G
P
V
H
R
A
V
A
T
P
G
D
L
L
F
H
I
R
A
S
R
L
D
L
C
F
A
L
A
T
E
I
M
G
R
L
R
G
A
V
T
P
Q
D
E
V
H
G
F
K
Y
F
D
E
R
D
M
L
G
F
V
D
G
T
E
N
P
T
---
G
A
A
-
A
R
R
A
V
L
V
G
A
E
D
P
A
F
A
G
G
S
Y
A
V
V
Q
K
Y
L
H
D
I
D
A
W
E
G
L
S
V
E
A
Q
E
R
V
I
G
R
R
K
M
T
D
V
E
L
S
D
D
V
K
P
A
D
S
H
V
A
L
T
S
V
T
G
P
D
G
S
D
L
E
I
L
R
D
N
M
P
F
G
S
V
G
R
E
E
F
G
T
Y
F
I
G
Y
A
R
T
P
E
V
T
E
T
M
L
E
R
M
F
L
G
T
A
S
A
P
H
D
R
I
L
D
F
S
T
A
V
T
G
S
L
F
F
T
P
A
A
D
F
L
----
E
D
L
P
A
R
P
----------------------
37
PsiBlast_CBE
96.17
60%
-94
- C3 -
4GU7
2
?
B:
[30-336]
-------
P
Q
M
V
L
-
S
P
L
T
S
A
A
I
F
L
V
V
T
I
--
D
S
--
G
--
G
E
D
T
V
R
D
L
L
S
D
V
A
S
L
E
R
A
V
G
F
R
A
Q
P
-
D
G
R
L
S
C
V
T
G
I
G
S
E
A
W
D
R
L
F
S
G
A
-
R
P
A
G
L
H
P
F
R
E
L
D
G
P
V
H
R
A
V
A
T
P
G
D
L
L
F
H
I
R
A
S
R
L
D
L
C
F
A
L
A
T
E
I
M
G
R
L
R
G
A
V
T
P
Q
D
E
V
H
G
F
K
Y
F
D
E
R
D
M
L
G
F
V
D
G
T
E
N
P
T
---
G
A
A
-
A
R
R
A
V
L
V
G
A
E
D
P
A
F
A
G
G
S
Y
A
V
V
Q
K
Y
L
H
D
I
D
A
W
E
G
L
S
V
E
A
Q
E
R
V
I
G
R
R
K
M
T
D
V
E
L
S
D
D
V
K
P
A
D
S
H
V
A
L
T
S
V
T
G
P
D
G
S
D
L
E
I
L
R
D
N
M
P
F
G
S
V
G
R
E
E
F
G
T
Y
F
I
G
Y
A
R
T
P
E
V
T
E
T
M
L
E
R
M
F
L
G
T
A
S
A
P
H
D
R
I
L
D
F
S
T
A
V
T
G
S
L
F
F
T
P
A
A
D
F
L
----
E
D
L
P
A
R
P
----------------------
33
PsiBlast_CBE
95.95
56%
-100
- C3 -
3VEG
2
?
C:
[9-317]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
L
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESLG-----------------------------
36
PsiBlast_CBE
95.94
60%
-95
- C3 -
4GU7
1
?
C:
[30-336]
-------
P
Q
M
V
L
-
S
P
L
T
S
A
A
I
F
L
V
V
T
I
--
D
S
--
G
--
G
E
D
T
V
R
D
L
L
S
D
V
A
S
L
E
R
A
V
G
F
R
A
Q
P
-
D
G
R
L
S
C
V
T
G
I
G
S
E
A
W
D
R
L
F
S
G
A
-
R
P
A
G
L
H
P
F
R
E
L
D
G
P
V
H
R
A
V
A
T
P
G
D
L
L
F
H
I
R
A
S
R
L
D
L
C
F
A
L
A
T
E
I
M
G
R
L
R
G
A
V
T
P
Q
D
E
V
H
G
F
K
Y
F
D
E
R
D
M
L
G
F
V
D
G
T
E
N
P
T
---
G
A
A
-
A
R
R
A
V
L
V
G
A
E
D
P
A
F
A
G
G
S
Y
A
V
V
Q
K
Y
L
H
D
I
D
A
W
E
G
L
S
V
E
A
Q
E
R
V
I
G
R
R
K
M
T
D
V
E
L
S
D
D
V
K
P
A
D
S
H
V
A
L
T
S
V
T
G
P
D
G
S
D
L
E
I
L
R
D
N
M
P
F
G
S
V
G
R
E
E
F
G
T
Y
F
I
G
Y
A
R
T
P
E
V
T
E
T
M
L
E
R
M
F
L
G
T
A
S
A
P
H
D
R
I
L
D
F
S
T
A
V
T
G
S
L
F
F
T
P
A
A
D
F
L
----
E
D
L
P
A
R
P
----------------------
41
HHSearch
95.83
57%
-99
- C3 -
3QNS
8
?
A:
[10-318]
----
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
--
S
D
D
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
----
E
S
L
G
D
------------------------
9
PsiBlast_PDB
95.57
60%
-95
- C3 -
4GU7
1
?
A:
[30-336]
-------
P
Q
M
V
L
-
S
P
L
T
S
A
A
I
F
L
V
V
T
I
--
D
S
--
G
--
G
E
D
T
V
R
D
L
L
S
D
V
A
S
L
E
R
A
V
G
F
R
A
Q
P
-
D
G
R
L
S
C
V
T
G
I
G
S
E
A
W
D
R
L
F
S
G
A
-
R
P
A
G
L
H
P
F
R
E
L
D
G
P
V
H
R
A
V
A
T
P
G
D
L
L
F
H
I
R
A
S
R
L
D
L
C
F
A
L
A
T
E
I
M
G
R
L
R
G
A
V
T
P
Q
D
E
V
H
G
F
K
Y
F
D
E
R
D
M
L
G
F
V
D
G
T
E
N
P
T
---
G
A
A
-
A
R
R
A
V
L
V
G
A
E
D
P
A
F
A
G
G
S
Y
A
V
V
Q
K
Y
L
H
D
I
D
A
W
E
G
L
S
V
E
A
Q
E
R
V
I
G
R
R
K
M
T
D
V
E
L
S
D
D
V
K
P
A
D
S
H
V
A
L
T
S
V
T
G
P
D
G
S
D
L
E
I
L
R
D
N
M
P
F
G
S
V
G
R
E
E
F
G
T
Y
F
I
G
Y
A
R
T
P
E
V
T
E
T
M
L
E
R
M
F
L
G
T
A
S
A
P
H
D
R
I
L
D
F
S
T
A
V
T
G
S
L
F
F
T
P
A
A
D
F
L
----
E
D
L
P
A
R
P
----------------------
31
PsiBlast_CBE
95.56
56%
-104
- C3 -
3VED
3
?
C:
[9-317]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
H
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESLG-----------------------------
34
PsiBlast_CBE
95.14
56%
-102
- C3 -
3VEG
2
?
B:
[9-318]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
L
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESLG
D
----------------------------
1
PsiBlast_PDB
95.02
56%
-104
- C3 -
3QNR
4
?
A:
[9-316]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
S
D
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
E
S
L------------------------------
21
PsiBlast_CBE
95.00
56%
-103
- C3 -
3QNR
3
?
C:
[9-316]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESL------------------------------
26
PsiBlast_CBE
94.99
56%
-104
- C3 -
3VEC
4
?
B:
[9-317]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
A
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESLG-----------------------------
30
PsiBlast_CBE
94.92
56%
-104
- C3 -
3VEE
3
?
B:
[9-317]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
A
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESLG-----------------------------
22
PsiBlast_CBE
94.80
56%
-103
- C3 -
3QNR
4
?
B:
[9-317]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESLG-----------------------------
8
PsiBlast_PDB
94.70
56%
-101
- C3 -
3VEG
2
?
A:
[9-316]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
S
D
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
L
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
E
S
L------------------------------
27
PsiBlast_CBE
94.64
56%
-101
- C3 -
4HOV
2
?
C:
[9-316]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
A
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESL------------------------------
32
PsiBlast_CBE
94.62
56%
-102
- C3 -
3VED
4
?
B:
[9-317]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
S
D
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
H
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
E
S
LG-----------------------------
28
PsiBlast_CBE
94.59
56%
-101
- C3 -
4HOV
3
?
B:
[9-317]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
A
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESLG-----------------------------
25
PsiBlast_CBE
94.55
56%
-101
- C3 -
3VEC
3
?
C:
[9-317]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
A
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESLG-----------------------------
29
PsiBlast_CBE
94.52
56%
-102
- C3 -
3VEE
2
?
C:
[9-316]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
A
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESL------------------------------
7
PsiBlast_PDB
94.49
56%
-103
- C3 -
3VED
4
?
A:
[9-316]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
S
D
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
H
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
-
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
E
S
L------------------------------
24
PsiBlast_CBE
94.14
56%
-99
- C3 -
3VEF
2
?
B:
[9-318]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
H
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESLG
D
----------------------------
23
PsiBlast_CBE
94.07
56%
-99
- C3 -
3VEF
2
?
C:
[9-316]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
SD
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
H
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
ESL------------------------------
6
PsiBlast_PDB
93.89
56%
-101
- C3 -
4HOV
5
?
A:
[9-316]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
S
D
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
A
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
E
S
L------------------------------
5
PsiBlast_PDB
93.69
56%
-103
- C3 -
3VEE
2
?
A:
[9-316]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
S
D
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
A
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
E
S
L------------------------------
4
PsiBlast_PDB
93.54
56%
-101
- C3 -
3VEC
4
?
A:
[9-316]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
S
D
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
A
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
N
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
E
S
L------------------------------
3
PsiBlast_PDB
93.45
56%
-100
- C3 -
3VEF
2
?
A:
[9-316]
---
A
R
L
A
P
Q
A
V
L
-
T
P
P
S
A
A
S
L
F
L
V
L
V
A
--
G
D
S
D
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
G
P
L
K
A
V
G
F
R
-
E
L
-
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
D
R
V
S
A
S
S
-
K
P
A
H
L
H
P
F
V
P
L
S
G
P
V
H
S
A
P
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
R
Y
F
D
S
R
D
L
L
G
F
V
D
G
T
E
N
P
T
---
D
D
D
-
A
A
D
S
A
L
I
G
D
E
D
P
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
S
T
E
E
Q
E
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
Q
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
E
H
D
I
L
R
D
H
M
A
F
G
S
L
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
K
D
P
A
V
T
E
L
M
L
R
R
M
F
L
G
E
P
P
G
N
Y
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
L
E
S
L------------------------------
10
PsiBlast_PDB
88.60
47%
-92
- C3 -
2GVK
12
?
A:
[14-312]
-------
P
Q
D
V
A
-
G
K
Q
G
E
N
V
I
F
I
V
Y
N
L
T
D
S
P
--
D
--
T
V
D
K
V
K
D
V
C
A
N
F
S
A
M
I
R
S
M
R
N
R
-
F
P
-
D
M
Q
F
S
C
T
M
G
F
G
A
D
A
W
T
R
L
F
P
D
K
G
K
P
K
E
L
S
T
F
S
E
I
K
G
E
K
Y
T
A
V
S
T
P
G
D
L
L
F
H
I
R
A
K
Q
M
G
L
C
F
E
F
A
S
I
L
D
E
K
L
K
G
A
V
V
S
V
D
E
T
H
G
F
R
Y
M
D
G
K
A
I
I
G
F
V
D
G
T
E
N
P
A
VDE
N
P
Y
-
H
F
--
A
V
I
G
E
E
D
A
D
F
A
G
G
S
Y
V
F
V
Q
K
Y
I
H
D
M
V
A
W
N
A
L
P
V
E
Q
Q
E
K
V
I
G
R
H
K
F
N
D
V
E
L
S
D
E
E
K
P
G
N
A
H
N
A
V
T
N
I
G
D
D
----
L
K
I
V
R
A
N
M
P
F
A
N
T
S
K
G
E
Y
G
T
Y
F
I
G
Y
A
S
T
F
S
T
T
R
R
M
L
E
N
M
F
I
G
S
P
A
G
N
T
D
R
L
L
D
F
S
T
A
I
T
G
T
L
F
F
V
P
S
Y
D
L
L
---------------------------------
45
HHSearch
88.38
48%
-88
- C3 -
2GVK
12
?
A:
[12-317]
-----
H
I
P
Q
D
V
A
-
G
K
Q
G
E
N
V
I
F
I
V
Y
N
L
--
T
D
--
S
PD
T
V
D
K
V
K
D
V
C
A
N
F
S
A
M
I
R
S
M
R
N
R
-
F
P
-
D
M
Q
F
S
C
T
M
G
F
G
A
D
A
W
T
R
L
F
P
D
K
G
K
P
K
E
L
S
T
F
S
E
I
K
G
E
K
Y
T
A
V
S
T
P
G
D
L
L
F
H
I
R
A
K
Q
M
G
L
C
F
E
F
A
S
I
L
D
E
K
L
K
G
A
V
V
S
V
D
E
T
H
G
F
R
Y
M
D
G
K
A
I
I
G
F
V
D
G
T
E
N
P
A
---
V
D
E
N
P
Y
H
F
A
V
I
G
E
E
D
A
D
F
A
G
G
S
Y
V
F
V
Q
K
Y
I
H
D
M
V
A
W
N
A
L
P
V
E
Q
Q
E
K
V
I
G
R
H
K
F
N
D
V
E
L
S
D
E
E
K
P
G
N
A
H
N
A
V
T
N
I
G
----
D
D
L
K
I
V
R
A
N
M
P
F
A
N
T
S
K
G
E
Y
G
T
Y
F
I
G
Y
A
S
T
F
S
T
T
R
R
M
L
E
N
M
F
I
G
S
P
A
G
N
T
D
R
L
L
D
F
S
T
A
I
T
G
T
L
F
F
V
P
S
Y
D
L
L
----
G
E
L
G
E
------------------------
42
HHSearch
81.38
36%
-94
- C3 -
2IIZ
5
?
A:
[6-311]
---
N
M
P
R
E
Q
L
G
V
C
A
E
G
N
L
H
S
V
Y
L
M
F
N
A
--
N
D
--
N
--
V
E
S
Q
L
R
P
C
I
A
N
V
A
Q
Y
I
Y
E
L
T
D
Q
-
Y
S
-
D
S
A
F
N
G
F
V
A
I
G
A
N
Y
W
D
S
L
Y
P
E
S
-
R
P
E
M
L
K
P
F
P
A
M
Q
E
G
N
R
E
A
P
A
I
E
Y
D
L
F
V
H
L
R
C
D
R
Y
D
I
L
H
L
V
A
N
E
I
S
Q
M
F
E
D
L
V
E
L
V
E
E
E
R
G
F
R
F
M
D
S
R
D
L
T
G
F
V
D
G
T
E
N
P
K
---
G
R
H
-
R
Q
E
V
A
L
V
G
S
E
D
P
E
F
K
G
G
S
Y
I
H
V
Q
K
Y
A
H
N
L
S
K
W
H
R
L
P
L
K
K
Q
E
D
I
I
G
R
T
K
Q
D
N
I
E
Y
E
S
E
D
K
P
L
T
S
H
I
K
R
V
N
L
K
D
E
N
G
K
S
I
E
I
L
R
Q
S
M
P
Y
G
S
L
--
K
E
Q
G
L
M
F
I
S
T
C
R
T
P
D
H
F
E
K
M
L
H
S
M
V
F
G
D
G
A
G
N
H
D
H
L
M
H
F
T
S
A
L
T
G
S
S
F
F
A
P
S
L
D
F
L
----
M
Q
F
D
-------------------------
12
PsiBlast_PDB
80.81
36%
-99
- C3 -
2IIZ
5
?
A:
[22-307]
-------------------
S
V
Y
L
M
F
N
A
--
N
D
--
N
--
V
E
S
Q
L
R
P
C
I
A
N
V
A
Q
Y
I
Y
E
L
T
D
Q
-
Y
S
-
D
S
A
F
N
G
F
V
A
I
G
A
N
Y
W
D
S
L
Y
P
E
S
-
R
P
E
M
L
K
P
F
P
A
M
Q
E
G
N
R
E
A
P
A
I
E
Y
D
L
F
V
H
L
R
C
D
R
Y
D
I
L
H
L
V
A
N
E
I
S
Q
M
F
E
D
L
V
E
L
V
E
E
E
R
G
F
R
F
M
D
S
R
D
L
T
G
F
V
D
G
T
E
N
P
K
---
G
R
H
-
R
Q
E
V
A
L
V
G
S
E
D
P
E
F
K
G
G
S
Y
I
H
V
Q
K
Y
A
H
N
L
S
K
W
H
R
L
P
L
K
K
Q
E
D
I
I
G
R
T
K
Q
D
N
I
E
Y
E
S
E
D
K
P
L
T
S
H
I
K
R
V
N
L
K
D
E
N
G
K
S
I
E
I
L
R
Q
S
M
P
Y
G
S
L
--
K
E
Q
G
L
M
F
I
S
T
C
R
T
P
D
H
F
E
K
M
L
H
S
M
V
F
G
D
G
A
G
N
H
D
H
L
M
H
F
T
S
A
L
T
G
S
S
F
F
A
P
S
L
D
F
L
---------------------------------
38
PsiBlast_CBE
78.78
37%
-91
- C3 -
5DE0
1
?
D:
[7-293]
------
S
Q
T
A
I
L
-
P
E
A
G
P
F
A
L
Y
T
L
L
K
V
--
R
Q
--
N
---
H
A
H
V
L
Q
A
L
K
A
L
P
A
L
V
E
E
I
N
Q
N
-
Q
P
-
G
A
E
L
T
V
S
V
A
F
S
K
G
F
W
S
H
-
F
E
M
A
-
S
P
P
E
L
I
D
F
P
E
L
G
E
G
E
T
H
A
P
S
T
D
V
D
V
L
I
H
C
H
A
T
R
H
D
L
L
F
Y
T
L
R
K
G
I
S
D
I
A
Q
D
I
E
I
V
D
E
T
Y
G
F
R
Y
L
D
A
R
D
M
T
G
F
I
D
G
T
E
N
P
K
---
A
E
K
-
R
A
E
V
A
L
V
A
D
G
D
--
F
A
G
G
S
Y
V
M
V
Q
R
F
V
H
N
L
P
A
W
N
R
L
N
L
A
A
Q
E
K
V
I
G
R
T
K
P
D
S
V
E
L
E
N
--
V
P
A
A
S
H
V
G
-
R
V
D
I
K
E
E
G
K
G
L
K
I
V
R
H
S
L
P
Y
G
S
V
S
-
G
D
H
G
L
L
F
I
A
Y
C
H
T
L
H
N
F
K
T
M
L
E
S
M
Y
-
G
V
T
D
G
K
T
D
Q
L
L
R
F
T
K
A
V
T
G
A
Y
F
F
A
P
S
-------------------------------------
13
PsiBlast_PDB
78.52
37%
-88
- C3 -
5DE0
1
?
A:
[7-293]
------
S
Q
T
A
I
L
-
P
E
A
G
P
F
A
L
Y
T
L
L
K
V
--
R
Q
--
N
---
H
A
H
V
L
Q
A
L
K
A
L
P
A
L
V
E
E
I
N
Q
N
-
Q
P
-
G
A
E
L
T
V
S
V
A
F
S
K
G
F
W
S
H
-
F
E
M
A
-
S
P
P
E
L
I
D
F
P
E
L
G
E
G
E
T
H
A
P
S
T
D
V
D
V
L
I
H
C
H
A
T
R
H
D
L
L
F
Y
T
L
R
K
G
I
S
D
I
A
Q
D
I
E
I
V
D
E
T
Y
G
F
R
Y
L
D
A
R
D
M
T
G
F
I
D
G
T
E
N
P
K
---
A
E
K
-
R
A
E
V
A
L
V
A
D
G
D
--
F
A
G
G
S
Y
V
M
V
Q
R
F
V
H
N
L
P
A
W
N
R
L
N
L
A
A
Q
E
K
V
I
G
R
T
K
P
D
S
V
E
L
E
N
--
V
P
A
A
S
H
V
G
-
R
V
D
I
K
E
E
G
K
G
L
K
I
V
R
H
S
L
P
Y
G
S
V
S
-
G
D
H
G
L
L
F
I
A
Y
C
H
T
L
H
N
F
K
T
M
L
E
S
M
Y
-
G
V
T
D
G
K
T
D
Q
L
L
R
F
T
K
A
V
T
G
A
Y
F
F
A
P
S
-------------------------------------
40
PsiBlast_CBE
78.49
37%
-88
- C3 -
5DE0
1
?
B:
[7-293]
------
S
Q
T
A
I
L
-
P
E
A
G
P
F
A
L
Y
T
L
L
K
V
--
R
Q
--
N
---
H
A
H
V
L
Q
A
L
K
A
L
P
A
L
V
E
E
I
N
Q
N
-
Q
P
-
G
A
E
L
T
V
S
V
A
F
S
K
G
F
W
S
H
-
F
E
M
A
-
S
P
P
E
L
I
D
F
P
E
L
G
E
G
E
T
H
A
P
S
T
D
V
D
V
L
I
H
C
H
A
T
R
H
D
L
L
F
Y
T
L
R
K
G
I
S
D
I
A
Q
D
I
E
I
V
D
E
T
Y
G
F
R
Y
L
D
A
R
D
M
T
G
F
I
D
G
T
E
N
P
K
---
A
E
K
-
R
A
E
V
A
L
V
A
D
G
D
--
F
A
G
G
S
Y
V
M
V
Q
R
F
V
H
N
L
P
A
W
N
R
L
N
L
A
A
Q
E
K
V
I
G
R
T
K
P
D
S
V
E
L
E
N
--
V
P
A
A
S
H
V
G
-
R
V
D
I
K
E
E
G
K
G
L
K
I
V
R
H
S
L
P
Y
G
S
V
S
-
G
D
H
G
L
L
F
I
A
Y
C
H
T
L
H
N
F
K
T
M
L
E
S
M
Y
-
G
V
T
D
G
K
T
D
Q
L
L
R
F
T
K
A
V
T
G
A
Y
F
F
A
P
S
-------------------------------------
39
PsiBlast_CBE
78.18
37%
-88
- C3 -
5DE0
1
?
C:
[7-293]
------
S
Q
T
A
I
L
-
P
E
A
G
P
F
A
L
Y
T
L
L
K
V
--
R
Q
--
N
---
H
A
H
V
L
Q
A
L
K
A
L
P
A
L
V
E
E
I
N
Q
N
-
Q
P
-
G
A
E
L
T
V
S
V
A
F
S
K
G
F
W
S
H
-
F
E
M
A
-
S
P
P
E
L
I
D
F
P
E
L
G
E
G
E
T
H
A
P
S
T
D
V
D
V
L
I
H
C
H
A
T
R
H
D
L
L
F
Y
T
L
R
K
G
I
S
D
I
A
Q
D
I
E
I
V
D
E
T
Y
G
F
R
Y
L
D
A
R
D
M
T
G
F
I
D
G
T
E
N
P
K
---
A
E
K
-
R
A
E
V
A
L
V
A
D
G
D
--
F
A
G
G
S
Y
V
M
V
Q
R
F
V
H
N
L
P
A
W
N
R
L
N
L
A
A
Q
E
K
V
I
G
R
T
K
P
D
S
V
E
L
E
N
--
V
P
A
A
S
H
V
G
-
R
V
D
I
K
E
E
G
K
G
L
K
I
V
R
H
S
L
P
Y
G
S
V
S
-
G
D
H
G
L
L
F
I
A
Y
C
H
T
L
H
N
F
K
T
M
L
E
S
M
Y
-
G
V
T
D
G
K
T
D
Q
L
L
R
F
T
K
A
V
T
G
A
Y
F
F
A
P
S
-------------------------------------
44
HHSearch
76.55
35%
-89
- C3 -
5DE0
1
?
A:
[6-301]
------
K
S
Q
T
A
I
L
P
E
A
G
P
F
A
L
Y
T
L
L
K
V
--
R
Q
-----
N
H
A
H
V
L
Q
A
L
K
A
L
P
A
L
V
E
E
I
N
Q
N
-
Q
P
-
G
A
E
L
T
V
S
V
A
F
S
K
G
F
W
S
H
F
E
M
A
--
S
P
P
E
L
I
D
F
P
E
L
G
E
G
E
T
H
A
P
S
T
D
V
D
V
L
I
H
C
H
A
T
R
H
D
L
L
F
Y
T
L
R
K
G
I
S
D
I
A
Q
D
I
E
I
V
D
E
T
Y
G
F
R
Y
L
D
A
R
D
M
T
G
F
I
D
G
T
E
N
P
K
---
A
E
K
-
R
A
E
V
A
L
V
A
--
D
G
D
F
A
G
G
S
Y
V
M
V
Q
R
F
V
H
N
L
P
A
W
N
R
L
N
L
A
A
Q
E
K
V
I
G
R
T
K
P
D
S
V
E
L
E
N
--
V
P
A
A
S
H
V
G
R
V
D
I
K
E
-
E
G
K
G
L
K
I
V
R
H
S
L
P
Y
G
S
V
S
-
G
D
H
G
L
L
F
I
A
Y
C
H
T
L
H
N
F
K
T
M
L
E
S
M
Y
G
V
T
-
D
G
K
T
D
Q
L
L
R
F
T
K
A
V
T
G
A
Y
F
F
A
P
S
Q
V
M
L
----
Q
E
L
T
-------------------------