@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0815c: (2016-04-26 )
MARCDVLVSADWAESNLHAPKVVFVEVDEDTSAYDRDHIAGAIKLDWRTDLQDPVKRDFVDAQQFSKLLSERGIANEDTVILYGGNNNWFAAYAYWYFKLYGHEKVKLLDGGRKKWELDGRPLSSDPVSRPVTSYTASPPDNTIRAFRDEVLAAINVKNLIDVRSPDEFSGKILAPAHLPQEQSQRPGHIPGAINVPWSRAANEDGTFKSDEELAKLYADAGLDNSKETIAYCRIGERSSHTWFVLRELLGHQNVKNYDGSWTEYGSLVGAPIELGS
Atome Classification :
(20 SA)
.........10.......----.20.-----------......-.30------.----------.-.......40.--....-...--50-..--......60........70........80......--.--.90........100.......110.......120....---...130--.....-...-.-140.......--150...------...--.160-........170........180.......190.......200....-..-.210.......220-----........230.......240.......250.......260.......270.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAR
C
D
V
L
V
SADWAESNLH----A
P
K
V
-----------
V
F
V
E
VD-ED-------T----------S-AYDRDHI
A
G
A
--
I
K
L
D
-WRT--DL-Q
D
--
P
V
K
R
D
F
V
D
A
Q
Q
F
S
K
L
L
S
ERGIANED
T
V
I
L
Y
GGNN--
N
--
W
F
A
A
Y
A
Y
W
Y
F
K
LYG
H
E
K
V
K
L
LDGGR
K
K
W
ELDGRPLSSD---PVSR----PVTSY-TAS-P-PD
N
T
I
R
A
F
R
D
--
E
V
L
A
A
I------NV
K
--
N
LI--DVRSPDEFS
G
-
K
I
LAPAHL
P
Q
E
QSQRPGHIPGAINVPWSRAANEDG-TF-K
S
D
E
E
L
A
K
L
Y
A
DA------GLDNSK
E
T
I
A
Y
C
RIGERSS
H
T
W
F
V
L
R
E
L
LGHQNVKNYDGS
W
T
EYGSLVGAPIELGS
2
PsiBlast_PDB
98.68
100%
-89
- C2 -
3AAX
-
THTR_MYCTU
A:
[4-277]
---
C
D
V
L
V
S
A
D
W
A
E
S
N
L
H
----
A
P
K
V
-----------
V
F
V
E
V
D
-
E
D
-------
T
----------
S
-
A
Y
D
R
D
H
I
A
G
A
--
I
K
L
D
-
W
R
T
--
D
L
-
Q
D
--
P
V
K
R
D
F
V
D
A
Q
Q
F
S
K
L
L
S
E
R
G
I
A
N
E
D
T
V
I
L
Y
G
G
N
N
--
N
--
W
F
A
A
Y
A
Y
W
Y
F
K
L
Y
G
H
E
K
V
K
L
L
D
G
G
R
K
K
W
E
L
D
G
R
P
L
S
S
D
---
P
V
S
R
----
P
V
T
S
Y
-
T
A
S
-
P
-
P
D
N
T
I
R
A
F
R
D
--
E
V
L
A
A
I
------
N
V
K
--
N
L
I
--
D
V
R
S
P
D
E
F
S
G
-
K
I
L
A
P
A
H
L
--
E
Q
S
Q
R
P
G
H
I
P
G
A
I
N
V
P
W
S
R
A
A
N
E
D
G
-
T
F
-
K
S
D
E
E
L
A
K
L
Y
A
D
A
------
G
L
D
N
S
K
E
T
I
A
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
R
E
L
L
G
H
Q
N
V
K
N
Y
D
G
S
W
T
E
Y
G
S
L
V
G
A
P
I
E
L
G
S
21
PsiBlast_CBE
98.00
99%
-86
- C2 -
3AAY
4
THTR_MYCTU
B:
[1-277]
M
A
R
C
D
V
L
V
S
A
D
W
A
E
S
N
L
H
----
A
P
K
V
-----------
V
F
V
E
V
D
-
E
D
-------
T
----------
S
-
A
Y
D
R
D
H
I
A
G
A
--
I
K
L
D
-
W
R
T
--
D
L
-
Q
D
--
P
V
K
R
D
F
V
D
A
Q
Q
F
S
K
L
L
S
E
R
G
I
A
N
E
D
T
V
I
L
Y
G
G
N
N
--
N
--
W
F
A
A
Y
A
Y
W
Y
F
K
L
Y
G
H
E
K
V
K
L
L
D
G
G
R
K
K
W
E
L
D
G
R
P
L
S
S
D
---
P
V
S
R
----
P
V
T
S
Y
-
T
A
S
-
P
-
P
D
N
T
I
R
A
F
R
D
--
E
V
L
A
A
I
------
N
V
K
--
N
L
I
--
D
V
R
S
P
D
E
F
S
G
-
K
I
L
A
P
A
H
L
P
Q
E
Q
S
Q
R
P
G
H
I
P
G
A
I
N
V
P
W
S
R
A
A
N
E
D
G
-
T
F
-
K
S
D
E
E
L
A
K
L
Y
A
D
A
------
G
L
D
N
S
K
E
T
I
A
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
R
E
L
L
G
H
Q
N
V
K
N
Y
D
G
S
W
T
E
Y
G
S
L
V
G
A
P
I
E
L
G
S
1
PsiBlast_PDB
97.21
100%
-89
- C2 -
3HWI
-
THTR_MYCTU
A:
[3-277]
--
R
C
D
V
L
V
S
A
D
W
A
E
S
N
L
H
----
A
P
K
V
-----------
V
F
V
E
V
D
-
E
D
-------
T
----------
S
-
A
Y
D
R
D
H
I
A
G
A
--
I
K
L
D
-
W
R
T
--
D
L
-
Q
D
--
P
V
K
R
D
F
V
D
A
Q
Q
F
S
K
L
L
S
E
R
G
I
A
N
E
D
T
V
I
L
Y
G
G
N
N
--
N
--
W
F
A
A
Y
A
Y
W
Y
F
K
L
Y
G
H
E
K
V
K
L
L
D
G
G
R
K
K
W
E
L
D
G
R
P
L
S
S
D
---
P
V
S
R
----
P
V
T
S
Y
-
T
A
S
-
P
-
P
D
N
T
I
R
A
F
R
D
--
E
V
L
A
A
I
------
N
V
K
--
N
L
I
--
D
V
R
S
P
D
E
F
S
G
-
K
I
L
A
P
--------
Q
R
P
G
H
I
P
G
A
I
N
V
P
W
S
R
A
A
N
E
D
G
-
T
F
-
K
S
D
E
E
L
A
K
L
Y
A
D
A
------
G
L
D
N
S
K
E
T
I
A
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
R
E
L
L
G
H
Q
N
V
K
N
Y
D
G
S
W
T
E
Y
G
S
L
V
G
A
P
I
E
L
G
S
24
HHSearch
97.18
100%
-90
- C2 -
3AAY
4
THTR_MYCTU
A:
[1-276]
M
A
R
C
D
V
L
V
S
A
D
W
A
E
S
N
L
H
----
A
P
K
V
-----------
V
F
V
E
V
D
E
D
--------
T
----------
S
-
A
Y
D
R
D
H
I
A
G
A
--
I
K
L
D
-
W
R
T
--
D
L
-
Q
D
--
P
V
K
R
D
F
V
D
A
Q
Q
F
S
K
L
L
S
E
R
G
I
A
N
E
D
T
V
I
L
Y
G
G
N
N
--
N
--
W
F
A
A
Y
A
Y
W
Y
F
K
L
Y
G
H
E
K
V
K
L
L
D
G
G
R
K
K
W
E
L
D
G
R
P
L
S
S
D
---
P
V
S
R
----
P
V
T
S
Y
-
T
A
S
-
P
-
P
D
N
T
I
R
A
F
R
D
--
E
V
L
A
A
I
------
N
V
K
--
N
L
I
--
D
V
R
S
P
D
E
F
S
G
-
K
I
L
A
-----
Q
E
Q
S
Q
R
P
G
H
I
P
G
A
I
N
V
P
W
S
R
A
A
N
E
D
G
-
T
F
-
K
S
D
E
E
L
A
K
L
Y
A
D
A
------
G
L
D
N
S
K
E
T
I
A
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
R
E
L
L
G
H
Q
N
V
K
N
Y
D
G
S
W
T
E
Y
G
S
L
V
G
A
P
I
E
L
G
-
3
PsiBlast_PDB
95.96
99%
-88
- C2 -
3AAY
4
THTR_MYCTU
A:
[1-277]
M
A
R
C
D
V
L
V
S
A
D
W
A
E
S
N
L
H
----
A
P
K
V
-----------
V
F
V
E
V
D
-
E
D
-------
T
----------
S
-
A
Y
D
R
D
H
I
A
G
A
--
I
K
L
D
-
W
R
T
--
D
L
-
Q
D
--
P
V
K
R
D
F
V
D
A
Q
Q
F
S
K
L
L
S
E
R
G
I
A
N
E
D
T
V
I
L
Y
G
G
N
N
--
N
--
W
F
A
A
Y
A
Y
W
Y
F
K
L
Y
G
H
E
K
V
K
L
L
D
G
G
R
K
K
W
E
L
D
G
R
P
L
S
S
D
---
P
V
S
R
----
P
V
T
S
Y
-
T
A
S
-
P
-
P
D
N
T
I
R
A
F
R
D
--
E
V
L
A
A
I
------
N
V
K
--
N
L
I
--
D
V
R
S
P
D
E
F
S
G
-
K
I
L
A
-----
Q
E
Q
S
Q
R
P
G
H
I
P
G
A
I
N
V
P
W
S
R
A
A
N
E
D
G
-
T
F
-
K
S
D
E
E
L
A
K
L
Y
A
D
A
------
G
L
D
N
S
K
E
T
I
A
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
R
E
L
L
G
H
Q
N
V
K
N
Y
D
G
S
W
T
E
Y
G
S
L
V
G
A
P
I
E
L
G
S
26
HHSearch
82.90
50%
-81
- C2 -
3HZU
2
THT2_MYCTU
A:
[38-309]
---
P
E
R
L
V
T
A
D
W
L
S
A
H
M
G
----
A
P
G
L
-----------
A
I
V
E
S
D
-
E
D
-------
V
----------
L
-
L
Y
D
V
G
H
I
P
G
A
--
V
K
I
D
-
W
H
T
--
D
L
-
N
D
--
P
R
V
R
D
Y
I
N
G
E
Q
F
A
E
L
M
D
R
K
G
I
A
R
D
D
T
V
V
I
Y
G
D
K
S
--
N
--
W
W
A
A
Y
A
L
W
V
F
T
L
F
G
H
A
D
V
R
L
L
N
G
G
R
D
L
W
L
A
E
R
R
E
T
T
L
D
---
V
P
T
K
----
T
C
T
G
Y
-
P
V
V
-
Q
R
N
D
A
P
I
R
A
F
R
D
--
D
V
L
A
I
L
------
G
A
Q
--
P
L
I
--
D
V
R
S
P
E
E
Y
T
G
-
K
R
T
H
M
P
D
Y
P
E
E
G
A
L
R
A
G
H
I
P
T
A
V
H
I
P
W
G
K
A
A
D
E
S
G
-
R
F
-
R
S
R
E
E
L
E
R
L
Y
D
--------
F
I
N
P
D
D
Q
T
V
V
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
T
H
L
L
G
K
A
D
V
R
N
Y
D
G
S
W
T
E
W
G
N
A
V
R
V
P
I
V
A
G
-
4
PsiBlast_PDB
82.48
49%
-81
- C2 -
3HZU
2
THT2_MYCTU
A:
[36-309]
-
A
H
P
E
R
L
V
T
A
D
W
L
S
A
H
M
G
----
A
P
G
L
-----------
A
I
V
E
S
D
-
E
D
-------
V
----------
L
-
L
Y
D
V
G
H
I
P
G
A
--
V
K
I
D
-
W
H
T
--
D
L
-
N
D
--
P
R
V
R
D
Y
I
N
G
E
Q
F
A
E
L
M
D
R
K
G
I
A
R
D
D
T
V
V
I
Y
G
D
K
S
--
N
--
W
W
A
A
Y
A
L
W
V
F
T
L
F
G
H
A
D
V
R
L
L
N
G
G
R
D
L
W
L
A
E
R
R
E
T
T
L
D
---
V
P
T
K
----
T
C
T
G
Y
P
V
V
Q
-
R
-
N
D
A
P
I
R
A
F
R
D
--
D
V
L
A
I
L
------
G
A
Q
--
P
L
I
--
D
V
R
S
P
E
E
Y
T
G
-
K
R
T
H
M
P
D
Y
P
E
E
G
A
L
R
A
G
H
I
P
T
A
V
H
I
P
W
G
K
A
A
D
E
S
G
-
R
F
-
R
S
R
E
E
L
E
R
L
Y
D
F
I
------
N
P
D
D
--
Q
T
V
V
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
T
H
L
L
G
K
A
D
V
R
N
Y
D
G
S
W
T
E
W
G
N
A
V
R
V
P
I
V
A
G
-
5
PsiBlast_PDB
77.42
49%
-74
- C2 -
3P3A
-
?
A:
[16-289]
-
A
H
P
E
R
L
V
T
A
D
W
L
A
S
N
L
G
----
R
P
G
L
-----------
V
I
V
E
S
D
-
E
D
-------
V
----------
L
-
L
Y
D
T
G
H
I
P
G
A
--
V
K
I
D
-
W
H
T
--
D
L
-
N
D
--
P
A
V
R
D
Y
I
N
G
E
Q
F
A
A
L
M
D
R
K
G
V
T
R
D
D
T
V
V
I
Y
G
D
K
S
--
N
--
W
W
A
A
Y
A
M
W
V
F
H
L
F
G
H
P
D
V
R
L
L
D
G
G
R
D
L
W
V
S
T
G
R
D
T
T
L
E
---
V
P
T
R
----
Q
T
S
G
Y
P
V
V
E
-
R
-
N
D
A
P
I
R
A
F
K
D
--
D
V
L
R
V
L
------
G
K
E
--
P
L
I
--
D
V
R
S
P
Q
E
Y
T
G
-
E
R
T
-----
P
E
E
G
A
L
R
G
G
H
I
P
T
A
V
S
V
P
W
S
K
A
A
Y
D
D
G
-
R
F
-
R
A
R
A
E
L
E
E
I
Y
G
F
V
------
K
P
D
D
--
K
P
I
V
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
T
Y
L
L
G
H
P
N
V
R
N
Y
D
G
S
W
T
E
W
G
N
A
V
R
V
P
I
V
V
G
-
29
HHSearch
70.14
27%
-68
- C2 -
1RHS
-
THTR_BOVIN
A:
[7-285]
----
R
A
L
V
S
T
K
W
L
A
E
S
V
R
A
GKV
G
P
G
L
-----------
R
V
L
D
A
S
-
W
Y
S
P
GTRE
A
R
----------
K
-
E
Y
L
E
R
H
V
P
G
A
--
S
F
F
D
-
I
E
E
--
C
R
-
D
K
AS
P
Y
E
V
M
L
P
S
E
A
G
F
A
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
D
G
D
D
LG
S
--
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
L
K
E
G
H
P
V
T
S
E
---
P
S
R
P
----
E
P
A
I
F
-
K
A
--
T
-
L
N
R
S
L
L
K
T
Y
E
--
Q
V
L
E
N
L
E
S
----
K
R
F
--
Q
L
V
--
D
S
R
A
Q
G
R
Y
L
G
-
T
Q
P
E
P
D
----
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
N
F
L
T
E
D
G
-
F
E
-
K
S
P
E
E
L
R
A
M
F
E
A
K
------
K
V
D
L
T
K
P
L
I
A
T
-
R
K
G
V
T
A
C
H
I
A
L
A
A
Y
L
-
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
F
H
-
R
A
P
P
E
----
6
PsiBlast_PDB
64.37
29%
-63
- C2 -
1H4K
5
THTR_AZOVI
X:
[17-271]
-------------
Q
A
R
L
S
----
A
P
E
L
-----------
I
L
V
D
L
T
--
S
-------
A
----------
A
-
R
Y
A
E
G
H
I
P
G
A
--
R
F
V
D
P
K
R
T
--
Q
L
G
Q
P
--
P
A
P
G
L
Q
P
P
R
E
Q
L
E
S
L
F
G
E
L
G
H
R
P
E
A
V
Y
V
V
Y
D
D
E
G
--
G
--
G
W
A
G
R
F
I
W
L
L
D
V
I
G
Q
Q
R
Y
H
Y
L
N
G
G
L
T
A
W
L
A
E
D
R
P
L
S
R
E
LPA
P
A
G
G
----
P
V
A
L
S
-
L
H
D
-
E
-
P
T
----
A
S
R
D
--
Y
L
L
G
R
L
------
G
A
A
--
D
L
A
IW
D
A
R
S
P
Q
E
Y
R
G
E
K
V
L
A
---------
A
K
G
G
H
I
P
G
A
V
N
F
E
W
T
A
A
M
D
P
S
R
-
A
L
-
R
I
R
T
D
I
A
G
R
L
E
E
L
------
G
I
T
P
D
K
E
I
V
T
H
C
Q
T
H
H
R
S
G
L
T
Y
L
I
A
K
A
-
L
G
Y
P
R
V
K
G
Y
A
G
S
W
G
E
W
G
N
H
P
D
T
P
V
E
L
--
32
HHSearch
64.04
25%
-64
- C2 -
3UTN
10
THTR_YEAST
X:
[26-319]
---
L
F
D
L
I
S
P
K
A
F
V
K
L
V
A
SEK-
V
H
R
I
-----------
V
P
V
D
A
T
-
W
--------
Y
LPSWKLDNKV
D
-
F
L
T
K
P
R
I
P
N
S
--
I
F
F
D
-
I
D
A
--
I
S
-
D
K
KS
P
Y
P
H
M
F
P
T
K
K
V
F
D
D
A
M
S
N
L
G
V
Q
K
D
D
I
L
V
V
Y
D
R
V
G
--
N
--
F
S
S
P
R
C
A
W
T
L
G
V
M
G
H
P
K
V
Y
L
L
N
N
-
F
N
Q
Y
R
E
F
K
Y
P
L
D
S
S
---
K
V
A
A
FSPY
P
K
S
H
Y
-
E
S
S
E
S
-
F
Q
D
K
E
I
V
D
Y
E
--
E
M
F
Q
L
V
KSGELA
K
K
F
--
N
A
F
--
D
A
R
S
L
G
R
F
E
G
-
T
E
P
E
P
R
-----
S
D
I
P
S
G
H
I
P
G
T
Q
P
L
P
Y
G
S
L
L
D
P
E
T
K
T
Y
P
E
A
G
E
A
I
H
A
T
L
E
K
A
LKDFHC
T
L
D
P
S
K
P
T
I
C
S
C
G
T
G
V
S
G
V
I
I
K
T
A
L
E
L
-
A
G
V
P
N
V
R
L
Y
D
G
S
W
T
E
W
V
L
-
K
S
G
P
-----
12
PsiBlast_PDB
63.73
27%
-56
- C2 -
3OLH
3
THTM_HUMAN
A:
[23-292]
------
M
V
S
A
Q
W
V
A
E
A
L
R
----
A
P
R
A
G
Q
P
L
Q
L
L
DA
S
W
Y
L
P
K
---
R
D
-------
A
----------
R
R
E
F
E
E
R
H
I
P
G
A
A
F
F
D
I
D
-
Q
C
S
--
D
R
-
T
S
--
P
Y
D
H
M
L
P
G
A
E
H
F
A
E
Y
A
G
R
L
G
V
G
A
A
T
H
V
V
I
Y
D
A
S
D
--
Q
GL
Y
S
A
P
R
V
W
W
M
F
R
A
F
G
H
H
A
V
S
L
L
D
G
G
L
R
H
W
L
R
Q
N
L
P
-
S
S
G
---
K
S
Q
P
----
A
P
A
E
F
-
R
A
Q
-
L
-
D
P
A
F
I
K
T
Y
E
D
I
K
E
N
L
E
S
R
------
R
F
Q
---
V
V
--
D
S
R
A
T
G
R
F
R
G
-
T
E
P
E
P
-----
R
D
G
I
E
P
G
H
I
P
G
T
V
N
I
P
F
T
D
F
L
S
Q
E
G
-
L
E
-
K
S
P
E
E
I
R
H
L
F
Q
E
K
------
K
V
D
L
S
K
P
L
V
A
T
C
G
S
G
V
T
A
C
H
V
-
A
L
G
A
Y
L
C
G
K
P
D
V
P
I
Y
D
G
S
W
V
E
W
------------
13
PsiBlast_PDB
63.58
29%
-59
- C2 -
1RHS
-
THTR_BOVIN
A:
[42-278]
--------------------------------------------
E
A
-------
R
----------
K
-
E
Y
L
E
R
H
V
P
G
A
--
S
F
F
D
-
I
E
E
CR
D
K
-
A
S
--
P
Y
E
V
M
L
P
S
E
A
G
F
A
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
D
G
D
D
LG
S
--
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
L
K
E
G
H
P
V
T
S
E
---
P
-
S
R
----
P
E
P
A
I
-
F
K
A
-
T
-
L
N
R
S
L
L
K
T
Y
E
--
Q
V
L
E
N
L
------
E
S
K
R
F
Q
L
V
--
D
S
R
A
----
Q
G
-
R
Y
L
G
T
Q
P
E
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
N
F
L
T
E
D
G
-
F
E
-
K
S
P
E
E
L
R
A
M
F
E
A
K
------
K
V
D
L
T
K
P
L
I
A
T
-
R
K
G
V
T
A
C
H
I
A
L
A
A
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
------------
7
PsiBlast_PDB
63.55
29%
-62
- C2 -
1H4M
2
THTR_AZOVI
X:
[17-271]
-------------
Q
A
R
L
S
----
A
P
E
L
-----------
I
L
V
D
L
T
--
S
-------
A
----------
A
-
R
Y
A
E
G
H
I
P
G
A
--
R
F
V
D
P
K
R
T
--
Q
L
G
Q
P
--
P
A
P
G
L
Q
P
P
R
E
Q
L
E
S
L
F
G
E
L
G
H
R
P
E
A
V
Y
V
V
Y
D
D
E
G
--
G
--
G
W
A
G
R
F
I
W
L
L
D
V
I
G
Q
Q
R
Y
H
Y
L
N
G
G
L
T
A
W
L
A
E
D
R
P
L
S
R
E
LPA
P
A
G
G
----
P
V
A
L
S
-
L
H
D
-
E
-
P
T
----
A
S
R
D
--
Y
L
L
G
R
L
------
G
A
A
--
D
L
A
IW
D
A
R
S
P
Q
E
Y
R
G
E
K
V
L
A
---------
A
K
G
G
H
I
P
G
A
V
N
F
E
W
T
A
A
M
D
P
S
R
-
A
L
-
R
I
R
T
D
I
A
G
R
L
E
E
L
------
G
I
T
P
D
K
E
I
V
T
H
C
Q
T
H
H
R
S
G
L
T
Y
L
I
A
K
A
-
L
G
Y
P
R
V
K
G
Y
A
G
S
W
G
E
W
G
N
H
P
D
T
P
V
E
L
--
10
PsiBlast_PDB
63.33
29%
-58
- C2 -
1BOI
-
THTR_BOVIN
A:
[42-278]
--------------------------------------------
E
A
-------
R
----------
K
-
E
Y
L
E
R
H
V
P
G
A
--
S
F
F
D
-
I
E
E
CR
D
K
-
A
S
--
P
Y
E
V
M
L
P
S
E
A
G
F
A
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
D
G
D
D
LG
S
--
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
L
K
E
G
H
P
V
T
S
E
---
P
-
S
R
----
P
E
P
A
I
-
F
K
A
-
T
-
L
N
R
S
L
L
K
T
Y
E
--
Q
V
L
E
N
L
------
E
S
K
R
F
Q
L
V
--
D
S
R
A
----
Q
G
-
R
Y
L
G
T
Q
P
E
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
N
F
L
T
E
D
G
-
F
E
-
K
S
P
E
E
L
R
A
M
F
E
A
K
------
K
V
D
L
T
K
P
L
I
A
T
-
R
K
G
V
T
A
C
H
I
A
L
A
A
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
------------
35
HHSearch
63.09
29%
-76
- C2 -
2EG4
7
?
A:
[4-229]
----------------------
P
E
D
A
-----------
V
L
V
D
T
R
-
P
--------
R
----------
P
-
A
Y
E
A
G
H
L
P
G
A
--
R
H
L
D
-
L
S
A
--
P
K
-
L
R
L
R
E
E
A
E
L
K
A
L
E
G
G
L
T
E
L
F
Q
T
L
G
L
--
R
S
P
V
V
L
Y
D
E
G
L
--
T
--
S
R
L
C
R
T
A
F
F
L
G
L
G
G
L
-
E
V
Q
L
W
T
E
G
W
E
P
Y
A
T
E
K
E
E
P
K
P
E
------------
R
T
E
V
-
V
A
--
K
-
L
R
R
D
W
L
L
T
A
D
--
E
A
---
A
------
R
H
P
--
L
L
L
--
D
V
R
S
P
E
E
F
Q
G
-
K
V
H
P
P
C
------
C
P
R
G
G
R
I
P
G
S
K
N
A
P
L
E
L
F
L
S
P
E
---------
G
---
L
L
E
R
L
------
G
L
Q
P
G
Q
E
V
G
V
Y
C
H
S
G
A
R
S
A
V
A
F
F
V
L
R
S
-
L
G
V
R
-
A
R
N
Y
L
G
S
M
H
E
W
L
Q
-
E
G
L
P
T
E
---
14
PsiBlast_PDB
62.77
28%
-58
- C2 -
1RHD
1
THTR_BOVIN
A:
[42-278]
--------------------------------------------
E
A
-------
R
----------
K
-
E
Y
L
E
R
H
V
P
G
A
--
S
F
F
D
-
I
E
E
CR
D
K
-
A
S
--
P
Y
E
V
M
L
P
S
E
A
G
F
A
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
N
G
D
D
LG
S
--
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
L
K
E
G
H
P
V
T
S
E
---
P
-
S
R
----
P
E
P
A
I
-
F
K
A
-
T
-
L
N
R
S
L
L
K
T
Y
E
--
Q
V
L
E
N
L
------
E
S
K
R
F
Q
L
V
--
D
S
R
A
----
Q
G
-
R
Y
L
G
T
Q
P
E
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
D
F
L
T
E
N
G
-
F
E
-
K
S
P
E
E
L
R
A
M
F
E
A
K
------
K
V
D
L
T
K
P
L
I
A
T
C
R
K
G
V
T
A
C
H
I
A
L
A
A
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
------------
9
PsiBlast_PDB
62.12
29%
-60
- C2 -
1BOH
-
THTR_BOVIN
A:
[42-278]
--------------------------------------------
E
A
-------
R
----------
K
-
E
Y
L
E
R
H
V
P
G
A
--
S
F
F
D
-
I
E
E
CR
D
K
-
A
S
--
P
Y
E
V
M
L
P
S
E
A
G
F
A
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
D
G
D
D
LG
S
--
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
L
K
E
G
H
P
V
T
S
E
---
P
-
S
R
----
P
E
P
A
I
-
F
K
A
-
T
-
L
N
R
S
L
L
K
T
Y
E
--
Q
V
L
E
N
L
------
E
S
K
R
F
Q
L
V
--
D
S
R
A
----
Q
G
-
R
Y
L
G
T
Q
P
E
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
N
F
L
T
E
D
G
-
F
E
-
K
S
P
E
E
L
R
A
M
F
E
A
K
------
K
V
D
L
T
K
P
L
I
A
T
-
R
K
G
V
T
A
C
H
I
A
L
A
A
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
------------
8
PsiBlast_PDB
62.07
29%
-58
- C2 -
1ORB
1
THTR_BOVIN
A:
[42-278]
--------------------------------------------
E
A
-------
R
----------
K
-
E
Y
L
E
R
H
V
P
G
A
--
S
F
F
D
-
I
E
E
CR
D
K
-
A
S
--
P
Y
E
V
M
L
P
S
E
A
G
F
A
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
D
G
D
D
LG
S
--
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
L
K
E
G
H
P
V
T
S
E
---
P
-
S
R
----
P
E
P
A
I
-
F
K
A
-
T
-
L
N
R
S
L
L
K
T
Y
E
--
Q
V
L
E
N
L
------
E
S
K
R
F
Q
L
V
--
D
S
R
A
----
Q
G
-
R
Y
L
G
T
Q
P
E
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
N
F
L
T
E
D
G
-
F
E
-
K
S
P
E
E
L
R
A
M
F
E
A
K
------
K
V
D
L
T
K
P
L
I
A
T
C
R
K
G
V
T
A
C
H
I
A
L
A
A
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
------------
11
PsiBlast_PDB
58.80
29%
-50
- C2 -
2ORA
-
THTR_BOVIN
A:
[42-278]
--------------------------------------------
E
A
-------
R
----------
K
-
E
Y
L
E
R
H
V
P
G
A
--
S
F
F
D
-
I
E
E
CR
D
K
-
A
S
--
P
Y
E
V
M
L
P
S
E
A
G
F
A
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
D
G
D
D
LG
S
--
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
L
K
E
G
H
P
V
T
S
E
---
P
-
S
R
----
P
E
P
A
I
-
F
K
A
-
T
-
L
N
R
S
L
L
K
T
Y
E
--
Q
V
L
E
N
L
------
E
S
K
R
F
Q
L
V
--
D
S
R
A
----
Q
G
-
R
Y
L
G
T
Q
P
E
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
N
F
L
T
E
D
G
-
F
E
-
K
S
P
E
E
L
R
A
M
F
E
A
K
------
K
V
D
L
T
K
P
L
I
A
T
C
R
K
G
V
T
A
C
H
I
A
L
A
A
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
------------