@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0858c: (2016-04-26 )
MTVSRLRPYATTVFAEMSALATRIGAVNLGQGFPDEDGPPKMLQAAQDAIAGGVNQYPPGPGSAPLRRAIAAQRRRHFGVDYDPETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAHRVTVPLVPDGRGFALDADALRRAVTPRTRALIINSPHNPTGAVLSATELAAIAEIAVAANLVVITDEVYEHLVFDHARHLPLAGFDGMAERTITISSAAKMFNCTGWKIGWACGPAELIAGVRAAKQYLSYVGGAPFQPAVALALDTEDAWVAALRNSLRARRDRLAAGLTEIGFAVHDSYGTYFLCADPRPLGYDDSTEFCAALPEKVGVAAIPMSAFCDPAAGQASQQADVWNHLVRFTFCKRDDTLDEAIRRLSVLAERPAT
Atome Classification :
(45 SA)
.........10........20.-.---......30........40-----.....--....50.---.--......60........70........80........90........100.......110.......120.......130.......140----.--------.-------..-------.....150.......160.......170.......180.......190.......200....-...210.......220-........230.......240.......250.......260.......270.--...-------...-------280-----.-------..--......290.......300.......310.......320----------......-----------.-.330--------.---------.......340.......350.......360......-.370.......380--........-390.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
V
S
RLR
P
Y
A
T
T
V
F
A
E
M
S
A
L
A
T
-
R
---IG
A
V
NLGQGFPDEDG
P
P
------
K
M
L
Q
A
--
A
Q
D
A
I
AG---G--VNQYPPGP
G
S
A
P
L
R
R
A
I
A
A
Q
R
R
R
HFGVDYDPET
E
V
L
V
T
VG
A
T
E
A
I
A
A
A
V
L
G
LVEPGS
E
V
L
L
IEPFYDSYS
P
V
V
A
MAGA
H
R
V
T
V
P
LVP------D--------G-------RG-------
F
A
L
D
A
D
A
L
R
R
AVTPR
T
R
A
L
I
I
NSPHNPTG
A
V
L
S
A
T
E
L
A
A
I
A
E
I
A
V
A
A
N
L
V
V
I
T
D
E
V
Y
E
H
L
V
F
-
D
HARHLPLAGFDGM
A
--
E
R
T
I
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I
S
SAA
K
M
FNCTG
W
K
I
GWAC
G
P
A
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V
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Y
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HDSY
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CAD-----------PRPLGY-----------D-DS
T
---------
E
---------
F
C
A
A
L
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KVGVAAI
P
M
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AFCDPAAGQA
S
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A
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W
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-
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TFCKRDD
T
L
---
D
E
A
I
R
R
L
S
-
V
L
AERPAT
21
PsiBlast_CBE
99.16
99%
-125
- C1 -
2O0R
4
DAPC_MYCTU
B:
[3-393]
-
T
V
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P
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P
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Y
-----------
D
-
D
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T
---------
E
---------
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A
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V
A
A
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P
M
S
A
F
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A
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D
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---
D
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A
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R
R
L
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-
V
L
A
-----
98
HHSearch
99.00
100%
-123
- C1 -
2O0R
3
DAPC_MYCTU
A:
[3-394]
-
T
V
S
R
L
R
P
Y
A
T
T
V
F
A
E
M
S
A
L
A
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R
---
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N
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Q
G
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---
G
--
V
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A
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V
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L
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L
L
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V
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M
A
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A
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V
T
V
P
L
V
P
------
D
--------
G
-------
R
G
-------
F
A
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A
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A
L
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R
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P
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A
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I
I
N
S
P
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N
P
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W
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A
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V
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A
A
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Q
Y
L
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Y
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G
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A
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A
-------
L
D
T
-------
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-------
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Y
-----------
D
-
D
S
T
---------
E
---------
F
C
A
A
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P
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K
V
G
V
A
A
I
P
M
S
A
F
C
D
P
--------
A
D
V
W
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H
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R
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K
R
D
D
T
L
---
D
E
A
I
R
R
L
S
-
V
L
A
E
----
1
PsiBlast_PDB
98.77
99%
-123
- C1 -
2O0R
3
DAPC_MYCTU
A:
[3-394]
-
T
V
S
R
L
R
P
Y
A
T
T
V
F
A
E
M
S
A
L
A
T
-
R
---
I
G
A
V
N
L
G
Q
G
F
P
D
E
D
G
P
P
------
K
M
L
Q
A
--
A
Q
D
A
I
A
G
---
G
--
V
N
Q
Y
P
P
G
P
G
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A
P
L
R
R
A
I
A
A
Q
R
R
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H
F
G
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D
Y
D
P
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T
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L
V
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V
G
A
T
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A
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A
A
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G
L
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L
L
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V
V
A
M
A
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A
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P
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------
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--------
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-------
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A
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A
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A
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A
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N
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W
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P
A
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A
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V
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A
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K
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Y
L
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Y
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G
G
A
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--
A
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A
-------
L
D
T
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-------
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-------
A
W
--
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A
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Y
G
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-----------
P
R
P
L
G
Y
-----------
D
-
D
S
T
---------
E
---------
F
C
A
A
L
P
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K
V
G
V
A
A
I
P
M
S
A
F
C
D
P
--------
A
D
V
W
N
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-
L
V
R
F
T
F
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K
R
D
D
T
L
---
D
E
A
I
R
R
L
S
-
V
L
A
E
----
14
PsiBlast_PDB
70.70
36%
-119
- C1 -
1GDE
4
?
A:
[29-386]
------------------------------
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
------
H
I
K
E
Y
--
A
K
E
A
L
D
K
---
G
--
L
T
H
Y
G
P
N
I
G
L
L
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L
R
E
A
I
A
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K
K
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N
G
I
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A
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A
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A
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Y
A
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A
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A
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G
K
P
V
E
V
P
T
Y
E
------
E
--------
D
-------
E
--------
F
R
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K
K
Y
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K
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A
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K
D
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V
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D
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Y
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D
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A
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G
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K
T
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A
M
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W
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W
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Y
A
A
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A
K
A
-------
L
K
D
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E
-------
R
-------
S
W
K
A
V
E
E
M
R
K
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Y
D
R
R
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K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
-----------
I
R
D
T
G
L
-------------
T
S
K
---------
K
---------
F
S
E
L
M
L
K
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A
R
V
A
V
V
P
G
S
A
F
G
K
A
G
E
G
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Y
V
R
I
S
Y
A
T
A
Y
E
K
L
---
E
E
A
M
D
R
M
E
R
V
L
K
E
R
---
15
PsiBlast_PDB
69.71
36%
-119
- C1 -
1GD9
2
?
A:
[29-386]
------------------------------
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
------
H
I
K
E
Y
--
A
K
E
A
L
D
K
---
G
--
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
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A
D
P
K
T
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I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
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A
F
L
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D
G
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Y
A
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A
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D
-------
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--------
F
R
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V
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A
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K
D
L
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F
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D
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D
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Y
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H
F
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Y
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D
D
A
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Y
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A
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M
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--
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K
F
Q
M
Y
N
A
T
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P
V
T
F
I
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Y
A
A
--
A
K
A
-------
L
K
D
-------
E
-------
R
-------
S
W
K
A
V
E
E
M
R
K
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Y
D
R
R
R
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L
V
W
K
R
L
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M
G
L
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K
P
K
G
A
F
Y
I
F
P
R
-----------
I
R
D
T
G
L
-------------
T
S
K
---------
K
---------
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
G
E
G
------------
Y
V
R
I
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Y
A
T
A
Y
E
K
L
---
E
E
A
M
D
R
M
E
R
V
L
K
E
R
---
85
HHSearch
69.67
38%
-112
- C1 -
3E2Y
6
KAT3_MOUSE
A:
[10-409]
----------
S
N
V
W
V
E
F
T
K
L
A
A
-
D
---
P
S
V
V
N
L
G
Q
G
F
P
D
I
S
P
P
S
------
Y
V
K
E
E
--
L
S
K
A
A
F
I
D--
N
--
M
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
P
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
V
P
V
F
I
P
L
R
S
------
K
PTDGMKWT
S
-------
S
D
-------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
-
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
--
A
E
A
-------
F
W
I
D
I
K
R
M
DD
P
-------
E
-------
C
Y
--
F
N
S
L
P
K
E
L
E
V
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
-----------
V
S
S
L
G
A
DLSDMNSDE--
P
-
Y
D
Y
---------
K
---------
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
D
S
K
S
------
K
P
H
F
E
K
-
L
V
R
F
C
F
I
K
K
D
S
T
L
---
D
A
A
E
E
I
F
R
-
A
W
------
95
HHSearch
69.66
35%
-113
- C1 -
4WLH
2
KAT1_HUMAN
A:
[11-420]
------
D
G
I
D
Y
N
P
W
V
E
F
V
K
L
A
S
-
E
---
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
P
P
D
------
F
A
V
E
A
--
F
Q
H
A
V
S
G
DF-
M
--
L
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
P
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
R
P
V
F
V
S
L
K
P
-------ELGS----
S
-------
S
N
-------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
-
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
--
E
R
T
L
T
I
G
S
A
G
-
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
--
A
E
S
-------
F
E
R
-------
E
Q
L
L
FRQP
S
-------
S
Y
--
F
V
Q
F
P
Q
A
M
Q
R
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
-----------
I
S
D
F
K
R
K
M
PDLPGAVDE
P
-
Y
D
R
---------
R
---------
F
V
K
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
S
V
P
H
Q
------
K
H
F
D
H
-
Y
I
R
F
C
F
V
K
D
E
A
T
L
---
Q
A
M
D
E
K
L
R
-
K
W
K
V
----
32
PsiBlast_CBE
69.53
36%
-119
- C1 -
1GD9
2
?
B:
[29-386]
------------------------------
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
------
H
I
K
E
Y
--
A
K
E
A
L
D
K
---
G
--
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
------
E
--------
D
-------
E
--------
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
-
D
D
A
R
H
Y
S
I
A
S
L
D
G
M
F
--
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
--
A
K
A
-------
L
K
D
-------
E
-------
R
-------
S
W
KA
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
-----------
I
R
D
T
G
L
-------------
T
S
K
---------
K
---------
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
G
E
G
------------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
---
E
E
A
M
D
R
M
E
R
V
L
K
E
R
---
30
PsiBlast_CBE
69.10
36%
-119
- C1 -
1DJU
2
?
B:
[28-385]
------------------------------
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
------
H
I
K
E
Y
--
A
K
E
A
L
D
K
---
G
--
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
------
E
--------
D
-------
E
--------
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
-
D
D
A
R
H
Y
S
I
A
S
L
D
G
M
F
--
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
--
A
K
A
-------
L
K
D
-------
E
-------
R
-------
S
W
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
-----------
I
R
D
T
G
L
-------------
T
S
K
---------
K
---------
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
G
E
G
------------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
---
E
E
A
M
E
R
M
E
R
V
L
K
E
R
---
90
HHSearch
69.05
37%
-112
- C1 -
1YIZ
3
?
A:
[24-428]
----------
K
S
V
W
V
E
Y
I
Q
L
A
A
-
Q
---
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
------
Y
A
L
N
A
--
L
A
A
A
A
N
S
PDP
L
--
A
N
Q
Y
T
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
D
R
T
I
N
P
M
T
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
G
G
I
P
R
F
I
P
L
K
P
------
N
--------
K
TGGTISS
A
D
-------
W
V
L
D
N
N
E
L
E
A
L
F
N
E
K
T
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
-
E
P
F
E
H
I
R
I
C
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
--
A
V
G
-------
F
E
T
-------
E
L
K
R
LKSP
E
-------
C
Y
--
F
N
S
I
S
G
E
L
M
A
K
R
D
Y
M
A
S
F
L
A
E
V
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
-----------
W
S
S
L
D
S
KVDLTQETDA-
R
-
K
D
Y
---------
R
---------
F
T
K
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
Y
S
E
P
N
------
K
H
L
G
E
D
-
F
V
R
Y
C
F
F
K
K
D
E
N
L
---
Q
K
A
A
E
I
L
R
-
K
W
K
G
S
---
31
PsiBlast_CBE
68.99
36%
-118
- C1 -
1GDE
4
?
B:
[29-386]
------------------------------
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
------
H
I
K
E
Y
--
A
K
E
A
L
D
K
---
G
--
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
------
E
--------
D
-------
E
--------
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
-
D
D
A
R
H
Y
S
I
A
S
L
D
G
M
F
--
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
--
A
K
A
-------
L
K
D
-------
E
-------
R
-------
S
W
KA
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
-----------
I
R
D
T
G
L
-------------
T
S
K
---------
K
---------
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
G
E
G
------------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
---
E
E
A
M
D
R
M
E
R
V
L
K
E
R
---
2
PsiBlast_PDB
68.92
38%
-117
- C1 -
1U08
2
YBDL_ECOLI
A:
[10-386]
---
S
K
L
P
Q
L
G
T
T
I
F
T
Q
M
S
A
L
A
Q
-
Q
---
H
Q
A
I
N
L
S
Q
G
F
P
D
F
D
G
P
R
------
Y
L
Q
E
R
--
L
A
H
H
V
A
Q
---
G
--
A
N
Q
Y
A
P
M
T
G
V
Q
A
L
R
E
A
I
A
Q
K
T
E
R
L
Y
G
Y
Q
P
D
A
D
S
D
I
T
V
T
A
G
A
T
E
A
L
Y
A
A
I
T
A
L
V
R
N
G
D
E
V
I
C
F
D
P
S
Y
D
S
Y
A
P
A
I
A
L
S
G
G
I
V
K
R
M
A
L
Q
P
------
P
--------
H
----------------
F
R
V
D
W
Q
E
F
A
A
L
L
S
E
R
T
R
L
V
I
L
N
T
P
H
N
P
S
A
T
V
W
Q
Q
A
D
F
A
A
L
W
Q
A
I
A
G
H
E
I
F
V
I
S
D
E
V
Y
E
H
I
N
F
-
S
Q
Q
G
H
A
S
V
L
A
H
P
Q
L
R
--
E
R
A
V
A
V
S
S
F
G
K
T
Y
H
M
T
G
W
K
V
G
Y
C
V
A
P
A
P
I
S
A
E
I
R
K
V
H
Q
Y
L
T
F
S
V
N
T
P
A
Q
L
A
L
--
A
D
M
-------
L
R
A
-------
E
-------
P
-------
E
H
--
Y
L
A
L
P
D
F
Y
R
Q
K
R
D
I
L
V
N
A
L
N
E
S
R
L
E
I
L
P
C
E
G
T
Y
F
L
L
V
D
-----------
Y
S
A
V
S
T
-----------
L
-
D
D
V
---------
E
---------
F
C
Q
W
L
T
Q
E
H
G
V
A
A
I
P
L
S
V
F
C
----------
A
D
P
F
P
H
K
L
I
R
L
C
F
A
K
K
E
S
T
L
---
L
A
A
A
E
R
L
R
-
Q
L
------
13
PsiBlast_PDB
68.64
36%
-121
- C1 -
1DJU
2
?
A:
[28-385]
------------------------------
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
------
H
I
K
E
Y
--
A
K
E
A
L
D
K
---
G
--
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
------
E
--------
D
-------
E
--------
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
-
D
D
A
R
H
Y
S
I
A
S
L
D
G
M
F
--
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
--
A
K
A
-------
L
K
D
-------
E
-------
R
-------
S
W
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
-----------
I
R
D
T
G
L
-------------
T
S
K
---------
K
---------
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
G
E
G
------------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
---
E
E
A
M
E
R
M
E
R
V
L
K
E
R
---
96
HHSearch
68.47
35%
-112
- C1 -
4WP0
-
KAT1_HUMAN
A:
[18-419]
-------------
W
V
E
F
V
K
L
A
S
-
E
---
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
P
P
D
------
F
A
V
E
A
--
F
Q
H
A
V
S
G
D
F
-
M
--
L
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
P
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
R
P
V
F
V
S
L
K
P
------
G
LGS-----
S
-------
S
N
-------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
-
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
--
E
R
T
L
T
I
G
S
A
G
-
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
--
A
E
S
-------
F
E
R
-------
E
Q
L
L
FRQP
S
-------
S
Y
--
F
V
Q
F
P
Q
A
M
Q
R
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
-----------
I
S
D
F
K
R
K
MPD
L
P
G
A
V
DE
P
-
Y
D
R
---------
R
---------
F
V
K
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
S
V
P
H
------
Q
K
H
F
D
H
-
Y
I
R
F
C
F
V
K
D
E
A
T
L
---
Q
A
M
D
E
K
L
R
-
K
W
K
-----
25
PsiBlast_CBE
68.45
36%
-115
- C1 -
3E2Z
5
KAT3_MOUSE
A:
[3-402]
---
K
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
-
D
---
P
S
V
V
N
L
G
Q
G
F
P
D
I
-
S
P
P
------
S
Y
V
K
E
E
L
S
K
A
A
F
I
D
---
N
--
M
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
P
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
V
P
V
F
I
P
L
R
S
KPT---
D
--------
G
MKWTS--
S
D
-------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
-
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
--
A
E
A
F
W
I
D
I
K
R
M
D
D
-------
P
-------
E
-------
C
Y
--
F
N
S
L
P
K
E
L
E
V
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
-----------
V
S
S
L
G
A
-----------
D
-
L
S
D
MNSDE
P
Y
D
Y
K
---------
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
D
------
S
K
S
K
P
H
F
E
K
-
L
V
R
F
C
F
I
K
K
D
S
T
L
---
D
A
A
--------------
4
PsiBlast_PDB
68.23
36%
-115
- C1 -
3E2Y
6
KAT3_MOUSE
A:
[3-402]
---
K
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
-
D
---
P
S
V
V
N
L
G
Q
G
F
P
D
I
-
S
P
P
------
S
Y
V
K
E
E
L
S
K
A
A
F
I
D
---
N
--
M
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
P
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
V
P
V
F
I
P
L
R
S
K
PT---
D
--------
G
MKWTS--
S
D
-------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
-
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
--
A
E
A
F
W
I
D
I
K
R
M
D
D
-------
P
-------
E
-------
C
Y
--
F
N
S
L
P
K
E
L
E
V
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
-----------
V
S
S
L
G
A
-----------
D
-
L
S
D
MNSDEP
Y
D
Y
K
---------
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
D
------
S
K
S
K
P
H
F
E
K
-
L
V
R
F
C
F
I
K
K
D
S
T
L
---
D
A
A
--------------
20
PsiBlast_PDB
67.94
33%
-112
- C1 -
4WP0
-
KAT1_HUMAN
A:
[18-424]
-------------
W
V
E
F
V
K
L
A
S
-
E
---
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
P
P
D
------
F
A
V
E
A
--
F
Q
H
A
V
S
G
---
D
F
M
L
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
P
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
R
P
V
F
V
S
L
K
P
GLG---
S
--------
S
-------
S
N
-------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
-
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
--
E
R
T
L
T
I
G
S
A
G
-
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
--
A
E
S
-------
F
E
R
-------
E
-------
Q
L
L
FRQPS
S
Y
--
F
V
Q
F
P
Q
A
M
Q
R
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
R
K
MPD
L
P
G
A
V
D
E
-----------
P
-
Y
D
R
---------
R
---------
F
V
K
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
------
S
V
P
H
Q
K
H
F
D
H
-
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
R
K
W
K
-
V
E
L
E
N
---
28
PsiBlast_CBE
67.45
34%
-115
- C1 -
2R5E
2
?
B:
[17-418]
---
K
R
Y
Q
G
S
T
K
S
V
W
V
E
Y
I
Q
L
A
A
-
Q
---
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
YALNAL
A
A
A
A
N
--
S
P
D
P
L
A
--------
N
Q
Y
T
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
D
R
T
I
N
P
M
T
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
G
G
I
P
R
F
I
P
L
K
P
------
N
--------
K
-------
T
G
GTISSAD
W
V
L
D
N
N
E
L
E
A
L
F
N
E
K
T
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
-
E
P
F
E
H
I
R
I
C
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
--
A
V
G
-------
F
E
T
-------
E
LKRLKSP
E
-------
C
Y
--
F
N
S
I
S
G
E
L
M
A
K
R
D
Y
M
A
S
F
L
A
E
V
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
-----------
W
S
S
L
D
S
-----------
K
V
D
L
T
---------
Q
ETDARKDYR
F
T
K
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
Y
S
E
P
N
K
H
L
G
E
D
-------
F
V
R
Y
C
F
F
K
K
D
E
N
L
---
Q
K
A
--------------
82
HHSearch
67.17
38%
-113
- C1 -
1U08
2
YBDL_ECOLI
A:
[8-385]
-
P
Q
S
K
L
P
Q
L
G
T
T
I
F
T
Q
M
S
A
L
A
Q
-
Q
---
H
Q
A
I
N
L
S
Q
G
F
P
D
F
D
G
P
R
------
Y
L
Q
E
R
--
L
A
H
H
V
A
Q
---
G
--
A
N
Q
Y
A
P
M
T
G
V
Q
A
L
R
E
A
I
A
Q
K
T
E
R
L
Y
G
Y
Q
P
D
A
D
S
D
I
T
V
T
A
G
A
T
E
A
L
Y
A
A
I
T
A
L
V
R
N
G
D
E
V
I
C
F
D
P
S
Y
D
S
Y
A
P
A
I
A
L
S
G
G
I
V
K
R
M
A
L
--------
Q
--------
P
-------
P
H
-------
F
R
V
D
W
Q
E
F
A
A
L
L
S
E
R
T
R
L
V
I
L
N
T
P
H
N
P
S
A
T
V
W
Q
Q
A
D
F
A
A
L
W
Q
A
I
A
G
H
E
I
F
V
I
S
D
E
V
Y
E
H
I
N
F
-
S
Q
Q
G
H
A
S
V
L
A
H
P
Q
L
R
--
E
R
A
V
A
V
S
S
F
G
K
T
Y
H
M
T
G
W
K
V
G
Y
C
V
A
P
A
P
I
S
A
E
I
R
K
V
H
Q
Y
L
T
F
S
V
N
T
P
A
Q
L
A
L
--
A
D
M
-------
L
R
A
-------
E
-------
P
-------
E
H
--
Y
L
A
L
P
D
F
Y
R
Q
K
R
D
I
L
V
N
A
L
N
E
S
R
L
E
I
L
P
C
E
G
T
Y
F
L
L
V
D
-----------
Y
S
A
V
S
T
-----------
L
-
D
D
V
---------
E
---------
F
C
Q
W
L
T
Q
E
H
G
V
A
A
I
P
L
S
V
F
C
A
D
P
---------
F
P
H
K
-
L
I
R
L
C
F
A
K
K
E
S
T
L
---
L
A
A
A
E
R
L
R
-
Q
-------
37
PsiBlast_CBE
67.17
33%
-112
- C1 -
4WLH
2
KAT1_HUMAN
A:
[18-420]
-------------
W
V
E
F
V
K
L
A
S
-
E
---
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
P
P
D
------
F
A
V
E
A
--
F
Q
H
A
V
S
G
---
D
FM
L
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
P
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
R
P
V
F
V
S
L
K
P
ELG---
S
--------
S
-------
S
N
-------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
-
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
--
E
R
T
L
T
I
G
S
A
G
T
-
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
--
A
E
S
-------
F
E
R
-------
E
-------
Q
L
L
FRQPS
S
Y
--
F
V
Q
F
P
Q
A
M
Q
R
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
I
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
R
K
M
PDL
P
G
A
V
D
E
-----------
P
-
Y
D
R
---------
R
---------
F
V
K
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
------
S
V
P
H
Q
K
H
F
D
H
-
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
R
K
W
K
-
V
-------
79
HHSearch
66.92
35%
-115
- C1 -
1GD9
2
?
A:
[12-386]
----------
A
S
E
I
R
K
L
F
D
I
A
A
G
M
---
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
------
H
I
K
E
Y
--
A
K
E
A
L
D
K
---
G
--
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
-------
E
--------
E
-------
D
E
-------
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
-
D
D
A
R
H
Y
S
I
A
S
L
D
G
M
F
--
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
--
A
K
A
-------
L
K
D
-------
E
R
S
-----
W
-------
K
A
--
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
-----------
I
R
D
T
G
------------
L
-
T
S
K
---------
K
---------
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
-----------
G
E
G
-
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
---
E
E
A
M
D
R
M
E
-
R
V
L
K
E
R
--
26
PsiBlast_CBE
66.85
36%
-116
- C1 -
3E2F
5
KAT3_MOUSE
B:
[3-402]
---
K
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
-
D
---
P
S
V
V
N
L
G
Q
G
F
P
D
I
-
S
P
P
------
S
Y
V
K
E
EL
S
K
A
A
F
I
D
---
N
--
M
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
P
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
V
P
V
F
I
P
L
R
S
KPT---
D
--------
G
MKWTS--
S
D
-------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
-
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
--
A
E
A
FWIDIKR
M
D
D
-------
P
-------
E
-------
C
Y
--
F
N
S
L
P
K
E
L
E
V
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
-----------
V
S
S
L
G
A
-----------
D
-
L
S
D
MNSDEPYDY
K
---------
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
D
------
S
K
S
K
P
H
F
E
K
-
L
V
R
F
C
F
I
K
K
D
S
T
L
---
D
A
A
--------------
8
PsiBlast_PDB
66.72
41%
-123
- C1 -
1V2F
4
?
A:
[13-368]
-----------
S
I
F
P
R
M
S
G
L
A
Q
-
R
---
L
G
A
V
N
L
G
Q
G
F
P
S
N
P
P
P
P
------
F
L
L
E
A
--
V
R
R
A
L
-
G
---
R
--
Q
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
E
----
F
A
V
E
--
P
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
G
A
K
A
R
L
V
R
L
D
L
------
T
--------
P
-------
E
G
-------
F
R
L
D
L
S
A
L
E
K
A
L
T
P
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
Y
Y
G
E
R
P
R
R
L
R
----
E
F
A
P
--
E
R
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
G
P
K
E
F
M
P
R
L
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
A
E
A
L
K
-------
L
A
R
-------
R
-------
E
-------
G
F
--
Y
E
A
L
R
E
G
Y
R
R
R
R
D
L
L
A
G
G
L
R
A
M
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L
----------
P
---
G
W
-----------
D
------------------------
A
F
R
L
V
E
E
A
R
V
A
L
I
P
A
S
A
F
Y
---------
L
E
D
P
P
K
D
-
L
F
R
F
A
F
C
K
T
E
E
E
L
---
H
L
A
L
E
R
L
G
-
R
V
V
-----
83
HHSearch
66.64
35%
-115
* C1 *
1B5P
3
AAT_THET8
A:
[31-382]
---------------------------
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
------
H
V
K
E
A
--
A
R
R
A
L
A
Q
---
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
-------
P
--------
E
-------
E
G
-------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
G
E
H
F
S
P
G
-
R
--
V
A
P
--
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
--
L
E
A
-------
L
T
N
-------
Q
E
A
S
----
R
-------
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
-----------
T
S
P
I
A
------------
P
-
D
E
V
---------
R
---------
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
-------------
F
G
-
H
V
R
L
S
Y
A
T
S
E
E
N
L
---
R
K
A
L
E
R
F
A
-
R
V
L
-----
11
PsiBlast_PDB
66.09
34%
-114
- C1 -
2R5E
2
?
A:
[17-418]
---
K
R
Y
Q
G
S
T
K
S
V
W
V
E
Y
I
Q
L
A
A
-
Q
---
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
Y
A
L
N
A
L
A
A
A
A
N
--
S
P
D
P
L
A
--------
N
Q
Y
T
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
D
R
T
I
N
P
M
T
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
G
G
I
P
R
F
I
P
L
K
P
------
N
--------
K
-------
T
G
GTISSAD
W
V
L
D
N
N
E
L
E
A
L
F
N
E
K
T
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
-
E
P
F
E
H
I
R
I
C
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
--
A
V
G
-------
F
E
T
-------
E
L
K
R
L
KSP
E
-------
C
Y
--
F
N
S
I
S
G
E
L
M
A
K
R
D
Y
M
A
S
F
L
A
E
V
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
-----------
W
S
S
L
D
S
-----------
K
V
D
L
T
---------
Q
ETDAR
K
D
Y
R
F
T
K
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
Y
S
E
P
N
K
H
L
G
E
D
-------
F
V
R
Y
C
F
F
K
K
D
E
N
L
---
Q
K
A
--------------
22
PsiBlast_CBE
66.02
36%
-113
- C1 -
3E2Y
6
KAT3_MOUSE
B:
[3-402]
---
K
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
-
D
---
P
S
V
V
N
L
G
Q
G
F
P
D
I
-
S
P
P
------
S
Y
V
K
E
EL
S
K
A
A
F
I
D
---
N
--
M
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
P
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
V
P
V
F
I
P
L
R
S
KPT---
D
--------
G
MKWTS--
S
D
-------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
-
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
--
A
E
A
FWIDIKR
M
D
D
-------
P
-------
E
-------
C
Y
--
F
N
S
L
P
K
E
L
E
V
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
-----------
V
S
S
L
G
A
-----------
D
-
L
S
D
MNSDEPYDY
K
---------
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
D
------
S
K
S
K
P
H
F
E
K
-
L
V
R
F
C
F
I
K
K
D
S
T
L
---
D
A
A
--------------
3
PsiBlast_PDB
66.00
36%
-113
- C1 -
3E2Z
5
KAT3_MOUSE
B:
[3-402]
---
K
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
-
D
---
P
S
V
V
N
L
G
Q
G
F
P
D
I
-
S
P
P
------
S
Y
V
K
E
E
L
S
K
A
A
F
I
D
---
N
--
M
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
P
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
V
P
V
F
I
P
L
R
S
K
PT---
D
--------
G
MKWTS--
S
D
-------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
-
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
--
A
E
A
F
W
I
D
I
K
R
M
D
D
-------
P
-------
E
-------
C
Y
--
F
N
S
L
P
K
E
L
E
V
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
-----------
V
S
S
L
G
A
-----------
D
-
L
S
D
MNSDEP
Y
D
Y
K
---------
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
D
------
S
K
S
K
P
H
F
E
K
-
L
V
R
F
C
F
I
K
K
D
S
T
L
---
D
A
A
--------------
7
PsiBlast_PDB
65.98
41%
-123
- C1 -
1V2E
4
?
A:
[13-368]
-----------
S
I
F
P
R
M
S
G
L
A
Q
-
R
---
L
G
A
V
N
L
G
Q
G
F
P
S
N
P
P
P
P
------
F
L
L
E
A
--
V
R
R
A
L
-
G
---
R
--
Q
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
E
----
F
A
V
E
--
P
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
G
A
K
A
R
L
V
R
L
D
L
------
T
--------
P
-------
E
G
-------
F
R
L
D
L
S
A
L
E
K
A
L
T
P
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
Y
Y
G
E
R
P
R
R
L
R
----
E
F
A
P
--
E
R
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
G
P
K
E
F
M
P
R
L
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
A
E
A
L
K
-------
L
A
R
-------
R
-------
E
-------
G
F
--
Y
E
A
L
R
E
G
Y
R
R
R
R
D
L
L
A
G
G
L
R
A
M
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L
----------
P
---
G
W
-----------
D
------------------------
A
F
R
L
V
E
E
A
R
V
A
L
I
P
A
S
A
F
Y
---------
L
E
D
P
P
K
D
-
L
F
R
F
A
F
C
K
T
E
E
E
L
---
H
L
A
L
E
R
L
G
-
R
V
V
-----
5
PsiBlast_PDB
65.81
36%
-113
- C1 -
3E2F
7
KAT3_MOUSE
A:
[3-402]
---
K
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
-
D
---
P
S
V
V
N
L
G
Q
G
F
P
D
I
-
S
P
P
------
S
Y
V
K
E
E
L
S
K
A
A
F
I
D
---
N
--
M
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
P
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
V
P
V
F
I
P
L
R
S
K
P
T---
D
--------
G
MKWTS--
S
D
-------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
-
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
--
A
E
A
F
W
I
D
I
K
R
M
D
D
-------
P
-------
E
-------
C
Y
--
F
N
S
L
P
K
E
L
E
V
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
-----------
V
S
S
L
G
A
-----------
D
-
L
S
D
MNSDE
P
Y
D
Y
K
---------
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
D
------
S
K
S
K
P
H
F
E
K
-
L
V
R
F
C
F
I
K
K
D
S
T
L
---
D
A
A
--------------
24
PsiBlast_CBE
65.73
41%
-122
- C1 -
1V2E
4
?
B:
[13-367]
-----------
S
I
F
P
R
M
S
G
L
A
Q
-
R
---
L
G
A
V
N
L
G
Q
G
F
P
S
N
P
P
P
P
------
F
L
L
E
A
--
V
R
R
A
L
-
G
---
R
--
Q
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
E
----
F
A
V
E
--
P
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
G
A
K
A
R
L
V
R
L
D
L
------
T
--------
P
-------
E
G
-------
F
R
L
D
L
S
A
L
E
K
A
L
T
P
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
Y
Y
G
E
R
P
R
R
L
R
----
E
F
A
P
--
E
R
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
G
P
K
E
F
M
P
R
L
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
AE
A
L
K
-------
L
A
R
-------
R
-------
E
-------
G
F
--
Y
E
A
L
R
E
G
Y
R
R
R
R
D
L
L
A
G
G
L
R
A
M
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L----------
P
---
G
W
-----------
D
------------------------
A
F
R
L
V
E
E
A
R
V
A
L
I
P
A
S
A
F
Y
---------
L
E
D
P
P
K
D
-
L
F
R
F
A
F
C
K
T
E
E
E
L
---
H
L
A
L
E
R
L
G
-
R
V
------
23
PsiBlast_CBE
65.64
41%
-121
- C1 -
1V2F
4
?
B:
[13-367]
-----------
S
I
F
P
R
M
S
G
L
A
Q
-
R
---
L
G
A
V
N
L
G
Q
G
F
P
S
N
P
P
P
P
------
F
L
L
E
A
--
V
R
R
A
L
-
G
---
R
--
Q
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
E
----
F
A
V
E
--
P
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
G
A
K
A
R
L
V
R
L
D
L
------
T
--------
P
-------
E
G
-------
F
R
L
D
L
S
A
L
E
K
A
L
T
P
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
Y
Y
G
E
R
P
R
R
L
R
----
E
F
A
P
--
E
R
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
G
P
K
E
F
M
P
R
L
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
AE
A
L
K
-------
L
A
R
-------
R
-------
E
-------
G
F
--
Y
E
A
L
R
E
G
Y
R
R
R
R
D
L
L
A
G
G
L
R
A
M
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L----------
P
---
G
W
-----------
D
------------------------
A
F
R
L
V
E
E
A
R
V
A
L
I
P
A
S
A
F
Y
---------
L
E
D
P
P
K
D
-
L
F
R
F
A
F
C
K
T
E
E
E
L
---
H
L
A
L
E
R
L
G
-
R
V
------
6
PsiBlast_PDB
65.22
36%
-113
- C1 -
2ZJG
5
KAT3_MOUSE
A:
[3-402]
---
K
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
-
D
---
P
S
V
V
N
L
G
Q
G
F
P
D
I
-
S
P
P
------
S
Y
V
K
E
E
L
S
K
A
A
F
I
D
---
N
--
M
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
P
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
V
P
V
F
I
P
L
R
S
K
PT---
D
--------
G
MKWTS--
S
D
-------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
-
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
--
A
E
A
F
W
I
D
IKR
M
D
D
-------
P
-------
E
-------
C
Y
--
F
N
S
L
P
K
E
L
E
V
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
-----------
V
S
S
L
G
A
-----------
D
-
L
S
D
MNSDE
P
Y
D
Y
K
---------
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
D
------
S
K
S
K
P
H
F
E
K
-
L
V
R
F
C
F
I
K
K
D
S
T
L
---
D
A
A
--------------
10
PsiBlast_PDB
65.18
34%
-116
- C1 -
2R5C
1
?
B:
[17-418]
---
K
R
Y
Q
G
S
T
K
S
V
W
V
E
Y
I
Q
L
A
A
-
Q
---
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
Y
A
L
N
A
L
A
A
A
A
N
--
S
P
D
P
L
A
--------
N
Q
Y
T
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
D
R
T
I
N
P
M
T
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
G
G
I
P
R
F
I
P
L
K
P
------
N
--------
K
-------
T
G
GTISSAD
W
V
L
D
N
N
E
L
E
A
L
F
N
E
K
T
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
-
E
P
F
E
H
I
R
I
C
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
--
A
V
G
-------
F
E
T
-------
E
L
K
R
L
KSP
E
-------
C
Y
--
F
N
S
I
S
G
E
L
M
A
K
R
D
Y
M
A
S
F
L
A
E
V
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
-----------
W
S
S
L
D
S
-----------
K
V
D
L
T
---------
Q
ETDAR
K
D
Y
R
F
T
K
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
Y
S
E
P
N
K
H
L
G
E
D
-------
F
V
R
Y
C
F
F
K
K
D
E
N
L
---
Q
K
A
--------------
16
PsiBlast_PDB
65.15
33%
-112
- C1 -
1W7N
1
KAT1_HUMAN
A:
[18-420]
-------------
W
V
E
F
V
K
L
A
S
-
E
---
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
P
P
D
------
F
A
V
E
A
--
F
Q
H
A
V
S
G
---
D
FM
L
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
P
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
R
P
V
F
V
S
L
K
P
GPGELG
S
--------
S
-------
S
N
-------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
-
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
--
E
R
T
L
T
I
G
S
A
G
K
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
--
A
E
S
-------
F
E
R
-------
E
-------
Q
L
L
FRQPS
S
Y
--
F
V
Q
F
P
Q
A
M
Q
R
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
L
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
R
K
MPDL
P
G
A
V
D
E
-----------
P
-
Y
D
R
---------
R
---------
F
V
K
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
------
S
V
P
H
Q
K
H
F
D
H
-
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
R
K
W
K
-
V
-------
41
PsiBlast_CBE
64.88
34%
-112
- C1 -
1B5P
3
AAT_THET8
A:
[8-379]
--
V
Q
A
M
K
P
S
A
T
-
V
A
V
N
A
K
A
L
E
L
-
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
------
H
V
K
E
A
--
A
R
R
A
L
A
Q
---
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
------
E
----------------
E
G
-------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
G
E
H
F
S
P
-----
G
R
V
AP
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
--
L
E
A
-------
L
T
N
-------
Q
-------
E
A
S
R
----
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
-----------
T
S
P
I
A
P
-----------
D
-
E
V
R
---------
A
---------
A
E
R
L
L
--
E
A
G
V
A
V
V
P
G
T
D
F
A
------------
A
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
---
R
K
A
L
E
R
F
A
---------
29
PsiBlast_CBE
64.59
34%
-115
- C1 -
1YIY
4
?
B:
[17-418]
---
K
R
Y
Q
G
S
T
K
S
V
W
V
E
Y
I
Q
L
A
A
-
Q
---
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
YALNAL
A
A
A
A
N
--
S
P
D
P
L
A
--------
N
Q
Y
T
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
D
R
T
I
N
P
M
T
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
G
G
I
P
R
F
I
P
L
K
P
------
N
--------
K
-------
T
G
GTISSAD
W
V
L
D
N
N
E
L
E
A
L
F
N
E
K
T
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
-
E
P
F
E
H
I
R
I
C
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
--
A
V
G
-------
F
E
T
-------
E
LKRLKSP
E
-------
C
Y
--
F
N
S
I
S
G
E
L
M
A
K
R
D
Y
M
A
S
F
L
A
E
V
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
-----------
W
S
S
L
D
S
-----------
K
V
D
L
T
---------
Q
ETDARKDYR
F
T
K
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
Y
S
E
P
N
K
H
L
G
E
D
-------
F
V
R
Y
C
F
F
K
K
D
E
N
L
---
Q
K
A
--------------
38
PsiBlast_CBE
64.58
34%
-109
- C1 -
1GCK
4
AAT_THET8
B:
[8-379]
--
V
Q
A
M
K
P
S
A
T
-
V
A
V
N
A
K
A
L
E
L
-
R
RQG
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
------
H
V
K
E
A
--
A
R
R
A
L
A
Q
---
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
------
E
----------------
E
G
-------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
G
E
H
F
S
P
-----
G
R
V
AP
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
--
L
E
A
-------
L
T
N
-------
Q
-------
E
ASR----
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
-----------
T
S
P
I
A
P
-----------
D
-
E
V
R
---------
A
---------
A
E
R
L
L
--
E
A
G
V
A
V
V
P
G
T
D
F
A
------------
A
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
---
R
K
A
L
E
R
F
A
---------
43
PsiBlast_CBE
64.05
34%
-113
- C1 -
1B5O
3
AAT_THET8
A:
[8-379]
--
V
Q
A
M
K
P
S
A
T
-
V
A
V
N
A
K
A
L
E
L
-
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
------
H
V
K
E
A
--
A
R
R
A
L
A
Q
---
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
------
E
----------------
E
G
-------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
G
E
H
F
S
P
-----
G
R
V
AP
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
--
L
E
A
-------
L
T
N
-------
Q
-------
E
A
S
R
----
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
-----------
T
S
P
I
A
P
-----------
D
-
E
V
R
---------
A
---------
A
E
R
L
L
--
E
A
G
V
A
V
V
P
G
T
D
F
A
------------
A
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
---
R
K
A
L
E
R
F
A
---------
42
PsiBlast_CBE
63.95
34%
-112
- C1 -
1B5O
3
AAT_THET8
B:
[8-379]
--
V
Q
A
M
K
P
S
A
T
-
V
A
V
N
A
K
A
L
E
L
-
R
RQG
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
------
H
V
K
E
A
--
A
R
R
A
L
A
Q
---
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
------
E
----------------
E
G
-------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
G
E
H
F
S
P
-----
G
R
V
AP
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
--
L
E
A
-------
L
T
N
-------
Q
-------
E
ASR----
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
-----------
T
S
P
I
A
P
-----------
D
-
E
V
R
---------
A
---------
A
E
R
L
L
--
E
A
G
V
A
V
V
P
G
T
D
F
A
------------
A
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
---
R
K
A
L
E
R
F
A
---------
53
PsiBlast_CBE
63.87
34%
-115
- C1 -
5BJ4
3
AAT_THET8
A:
[31-379]
---------------------------
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
------
H
V
K
E
A
--
A
R
R
A
L
A
Q
---
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
------
E
----------------
E
G
-------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
G
E
H
F
S
P
-----
G
R
V
AP
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
--
L
E
A
-------
L
T
N
-------
Q
-------
E
A
S
R
----
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
-----------
T
S
P
I
A
P
-----------
D
-
E
V
R
---------
A
---------
A
E
R
L
L
--
E
A
G
V
A
V
V
P
G
T
D
F
A
------------
A
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
---
R
K
A
L
E
R
F
A
---------
27
PsiBlast_CBE
62.96
36%
-112
- C1 -
2ZJG
6
KAT3_MOUSE
B:
[3-402]
---
K
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
L
A
A
-
D
---
P
S
V
V
N
L
G
Q
G
F
P
D
I
-
S
P
P
------
S
Y
V
K
E
EL
S
K
A
A
F
I
D
---
N
--
M
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
P
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
G
A
V
P
V
F
I
P
L
R
S
KPT---
D
--------
G
MKWTS--
S
D
-------
W
T
F
D
P
R
E
L
E
S
K
F
S
S
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
-
T
G
H
T
H
V
K
I
A
T
L
P
G
M
W
--
E
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
--
A
E
A
FWIDIKR
M
D
D
-------
P
-------
E
-------
C
Y
--
F
N
S
L
P
K
E
L
E
V
K
R
D
R
M
V
R
L
L
N
S
V
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
-----------
V
S
S
L
G
A
-----------
D
-
L
S
D
MNSDEPYDY
K
---------
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
D
------
S
K
S
K
P
H
F
E
K
-
L
V
R
F
C
F
I
K
K
D
S
T
L
---
D
A
A
--------------
17
PsiBlast_PDB
62.96
33%
-109
- C1 -
1W7M
1
KAT1_HUMAN
A:
[18-420]
-------------
W
V
E
F
V
K
L
A
S
-
E
---
H
D
V
V
N
L
G
Q
G
F
P
D
F
P
P
P
D
------
F
A
V
E
A
--
F
Q
H
A
V
S
G
---
D
FM
L
N
Q
Y
T
K
T
F
G
Y
P
P
L
T
K
I
L
A
S
F
F
G
E
L
L
G
Q
E
I
D
P
L
R
N
V
L
V
T
V
G
G
Y
G
A
L
F
T
A
F
Q
A
L
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
T
M
M
A
G
G
R
P
V
F
V
S
L
K
P
GPGELG
S
--------
S
-------
S
N
-------
W
Q
L
D
P
M
E
L
A
G
K
F
T
S
R
T
K
A
L
V
L
N
T
P
N
N
P
L
G
K
V
F
S
R
E
E
L
E
L
V
A
S
L
C
Q
Q
H
D
V
V
C
I
T
D
E
V
Y
Q
W
M
V
Y
-
D
G
H
Q
H
I
S
I
A
S
L
P
G
M
W
--
E
R
T
L
T
I
G
S
A
G
K
T
F
S
A
T
G
W
K
V
G
W
V
L
G
P
D
H
I
M
K
H
L
R
T
V
H
Q
N
S
V
F
H
C
P
T
Q
S
Q
A
A
V
--
A
E
S
-------
F
E
R
-------
E
-------
Q
L
LFRQPS
S
Y
--
F
V
Q
F
P
Q
A
M
Q
R
C
R
D
H
M
I
R
S
L
Q
S
V
G
L
K
P
L
I
P
Q
G
S
Y
F
L
I
T
D
I
S
D
F
K
R
KMPDL
P
G
A
V
D
E
-----------
P
-
Y
D
R
---------
R
---------
F
V
K
W
M
I
K
N
K
G
L
V
A
I
P
V
S
I
F
Y
------
S
V
P
H
Q
K
H
F
D
H
-
Y
I
R
F
C
F
V
K
D
E
A
T
L
Q
A
M
D
E
K
L
R
K
W
K
-
V
-------
40
PsiBlast_CBE
62.70
34%
-112
- C1 -
1B5P
3
AAT_THET8
B:
[8-379]
--
V
Q
A
M
K
P
S
A
T
-
V
A
V
N
A
K
A
L
E
L
-
R
RQG
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
------
H
V
K
E
A
--
A
R
R
A
L
A
Q
---
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
------
E
----------------
E
G
-------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
G
E
H
F
S
P
-----
G
R
V
AP
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
--
L
E
A
-------
L
T
N
-------
Q
-------
E
ASR----
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
-----------
T
S
P
I
A
P
-----------
D
-
E
V
R
---------
A
---------
A
E
R
L
L
--
E
A
G
V
A
V
V
P
G
T
D
F
A
------------
A
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
---
R
K
A
L
E
R
F
A
---------
52
PsiBlast_CBE
62.16
34%
-113
- C1 -
5BJ4
3
AAT_THET8
B:
[31-379]
---------------------------
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
------
H
V
K
E
A
--
A
R
R
A
L
A
Q
---
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
------
E
----------------
E
G
-------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
G
E
H
F
S
P
-----
G
R
V
AP
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
--
L
E
A
-------
L
T
N
-------
Q
-------
E
ASR----
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
-----------
T
S
P
I
A
P
-----------
D
-
E
V
R
---------
A
---------
A
E
R
L
L
--
E
A
G
V
A
V
V
P
G
T
D
F
A
------------
A
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
---
R
K
A
L
E
R
F
A
---------
39
PsiBlast_CBE
61.86
34%
-107
- C1 -
1GCK
4
AAT_THET8
A:
[8-379]
--
V
Q
A
M
K
P
S
A
T
-
V
A
V
N
A
K
A
L
E
L
-
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
------
H
V
K
E
A
--
A
R
R
A
L
A
Q
---
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
------
E
----------------
E
G
-------
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
G
E
H
F
S
P
-----
G
R
V
AP
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
--
L
E
A
-------
L
T
N
-------
Q
-------
E
A
S
R
----
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
-----------
T
S
P
I
A
P
-----------
D
-
E
V
R
---------
A
---------
A
E
R
L
L
--
E
A
G
V
A
V
V
P
G
T
D
F
A
------------
A
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
---
R
K
A
L
E
R
F
A
---------