@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0860: (2016-04-26 )
MPDNTIQWDKDADGIVTLTMDDPSGSTNVMNEAYIESMGKAVDRLVAEKDSITGVVVASAKKTFFAGGDVKTMIQARPEDAGDVFNTVETIKRQLRTLETLGKPVVAAINGAALGGGLEIALACHHRIAADVKGSQLGLPEVTLGLLPGGGGVTRTVRMFGIQNAFVSVLAQGTRFKPAKAKEIGLVDELVATVEELVPAAKAWIKEELKANPDGAGVQPWDKKGYKMPGGTPSSPGLAAILPSFPSNLRKQLKGAPMPAPRAILAAAVEGAQVDFDTASRIESRYFASLVTGQVAKNMMQAFFFDLQAINAGGSRPEGIGKTPIKRIGVLGAGMMGAGIAYVSAKAGYEVVLKDVSLEAAAKGKGYSEKLEAKALERGRTTQERSDALLARITPTADAADFKGVDFVIEAVFENQELKHKVFGEIEDIVEPNAILGSNTSTLPITGLATGVKRQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYTLAIGKTPIVVNDSRGFFTSRVIGTFVNEALAMLGEGVEPASIEQAGSQAGYPAPPLQLSDELNLELMHKIAVATRKGVEDAGGTYQPHPAEAVVEKMIELGRSGRLKGAGFYEYADGKRSGLWPGLRETFKSGSSQPPLQDMIDRMLFAEALETQKCLDEGVLTSTADANIGSIMGIGFPPWTGGSAQFIVGYSGPAGTGKAAFVARARELAAAYGDRFLPPESLLS
Atome Classification :
(30 SA)
--.........10........20........30........40........50........60.-.......70.....-...80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.---......190.--......200.......210.-.-.-....220.-.-----.....230.......240.........250...--..-..260......----.270.......280.......290.......300.......---310....-.----.-.320.......330....-...340.......350.......360...-....370---.......--.-----380.......390.......400.-.......410.......420.......430.......440.......450.......460.......470........480........490.......500.......510.......520.......530.......540---..--......550.......560.......570....------...580-------....----.....590.......600.....---------..610--.......--620-...--------..--...------.630--------.......640.......650.......660.......670.......680.......690.......700.......--710.......720--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MPDNTIQWDKDAD
G
I
V
T
L
T
MDDPSGST
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
AEKDSI
T
G
V
V
V
ASAK
K
-
T
F
FAGG
D
V
K
T
M
I
QA-RPEDA
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
LG
K
P
V
V
A
AINGAALGGG
L
E
I
A
L
ACH
H
R
I
AADVKGSQLGL
P
E
V
T
L
G
L
LPGGGG
V
T
R
T
V
R
MFG
I
Q
N
A
F
V
S
V
LAQGTRFKPAK
A
K
E---IG
L
V
D
E
L
V
A
T
--
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
KANP-D-G-AGVQPWDK-K-----GYKMPGGTPSSP
G
L
A
A
--ILPS
F
P
S
N
L
R
K
Q
LKG--AP-MPA
P
R
A
I
L
A
A
A----VEG
A
Q
VDF
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
---INAGGSR-P----E-GIGK
T
P
I
K
R
I
GVLGA
G
M
M-GA
G
I
A
Y
V
SAKAG
Y
E
V
V
L
K
DV
S
L
E
AAAKGK-G
Y
S
E
K
L
----
E
A
K
A
L
ER--G-----RTT
Q
E
RSD
A
L
L
A
R
ITPTADAAD-F-K
G
V
D
F
V
I
E
A
V
FEN
Q
E
L
K
H
K
V
F
G
E
I
E
D
IVEPNAILGSNTS
T
L
P
I
T
G
LATGVKRQE
D
F
I
G
I
H
FFSPVDKM-
P
L
V
E
I
IKGEK-T
S
D
E
A
L
A
R
V
F
D
Y
T
LAIGKT
P
I
V
V
NDSRG
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
LGEGVE
P
A
S
I
E
QAGSQ----AG--YPAPPLQLSDEL
N
L
E
L
M
H
K
I
A
V
A
T
RKGVEDAGG------TYQP---------H
P
A
E
----
A
V
V
E
K
M
I
E
LGRSGRLKGA
G
F
Y
EY---------ADGKR--SGLW
P
G
L
--
R
---
E
T
F
--------KS--GSS------QP
P
L
--------
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
EGVLTSTADANI
G
S
I
M
GIGFPPWTGGS
A
Q
F
I
V
G
YSGPAGT
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
YG--DRFL
P
P
E
S
LLS----------
1
PsiBlast_PDB
98.88
100%
-88
- C2 -
4B3H
10
?
A:
[17-736]
--
M
P
D
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
-
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
---
I
G
L
V
D
E
L
V
A
T
--
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
-
D
-
G
-
A
G
V
Q
P
W
D
K
-
K
-----
G
Y
K
M
P
G
G
T
P
S
S
P
G
L
A
A
--
I
L
P
S
F
P
S
N
L
R
K
Q
L
K
G
--
A
P
-
M
P
A
P
R
A
I
L
A
A
A
----
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
---
I
N
A
G
G
S
R
-
P
----
E
-
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
-
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
-
G
Y
S
E
K
L
----
E
A
K
A
L
E
R
--
G
-----
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
-
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
-
P
L
V
E
I
I
K
G
E
K
-
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
----
A
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
------
T
Y
Q
P
---------
H
P
A
E
----
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
---------
A
D
G
K
R
--
S
G
L
W
P
G
L
--
R
---
E
T
F
--------
K
S
--
G
S
S
------
Q
P
P
L
--------
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
Y
S
G
P
A
G
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
--
D
R
F
L
P
P
E
S
L
L
S
----------
3
PsiBlast_PDB
98.46
100%
-88
- C2 -
4B3J
10
?
A:
[17-736]
--
M
P
D
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
-
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
---
I
G
L
V
D
E
L
V
A
T
--
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
-
D
-
G
-
A
G
V
Q
P
W
D
K
-
K
-----
G
Y
K
M
P
G
G
T
P
S
S
P
G
L
A
A
--
I
L
P
S
F
P
S
N
L
R
K
Q
L
K
G
--
A
P
-
M
P
A
P
R
A
I
L
A
A
A
----
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
---
I
N
A
G
G
S
R
-
P
----
E
-
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
-
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
-
G
Y
S
E
K
L
----
E
A
K
A
L
E
R
--
G
-----
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
-
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
-
P
L
V
E
I
I
K
G
E
K
-
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
----
A
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
------
T
Y
Q
P
---------
H
P
A
E
----
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
---------
A
D
G
K
R
--
S
G
L
W
P
G
L
--
R
---
E
T
F
--------
K
S
--
G
S
S
------
Q
P
P
L
--------
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
Y
S
G
P
A
G
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
--
D
R
F
L
P
P
E
S
L
L
S
----------
21
PsiBlast_CBE
98.25
100%
-86
- C2 -
4B3H
11
?
B:
[17-736]
--
M
P
D
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
-
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
---
I
G
L
V
D
E
L
V
A
T
--
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
-
D
-
G
-
A
G
V
Q
P
W
D
K
-
K
-----
G
Y
K
M
P
G
G
T
P
S
S
P
G
L
A
A
--
I
L
P
S
F
P
S
N
L
R
K
Q
L
K
G
--
A
P
-
M
P
A
P
R
A
I
L
A
A
A
----
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
---
I
N
A
G
G
S
R
-
P
----
E
-
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
-
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
-
G
Y
S
E
K
L
----
E
A
K
A
L
E
R
--
G
-----
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
-
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
-
P
L
V
E
I
I
K
G
E
K
-
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
----
A
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
------
T
Y
Q
P
---------
H
P
A
E
----
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
---------
A
D
G
K
R
--
S
G
L
W
P
G
L
--
R
---
E
T
F
--------
K
S
--
G
S
S
------
Q
P
P
L
--------
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
Y
S
G
P
A
G
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
--
D
R
F
L
P
P
E
S
L
L
S
----------
2
PsiBlast_PDB
98.03
100%
-88
- C2 -
4B3I
10
?
A:
[17-736]
--
M
P
D
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
-
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
---
I
G
L
V
D
E
L
V
A
T
--
V
E
E
L
V
P
A
A
K
A
W
I
K
E
E
L
K
A
N
P
-
D
-
G
-
A
G
V
Q
P
W
D
K
-
K
-----
G
Y
K
M
P
G
G
T
P
S
S
P
G
L
A
A
--
I
L
P
S
F
P
S
N
L
R
K
Q
L
K
G
--
A
P
-
M
P
A
P
R
A
I
L
A
A
A
----
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
---
I
N
A
G
G
S
R
-
P
----
E
-
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
-
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
-
G
Y
S
E
K
L
----
E
A
K
A
L
E
R
--
G
-----
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
-
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
-
P
L
V
E
I
I
K
G
E
K
-
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
----
A
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
A
G
G
------
T
Y
Q
P
---------
H
P
A
E
----
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
---------
A
D
G
K
R
--
S
G
L
W
P
G
L
--
R
---
E
T
F
--------
K
S
--
G
S
S
------
Q
P
P
L
--------
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
Y
S
G
P
A
G
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
--
D
R
F
L
P
P
E
S
L
L
S
----------
105
HHSearch
97.03
97%
-87
- C2 -
4B3H
10
?
A:
[18-735]
---
P
D
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
I
T
G
V
V
V
A
S
A
-
K
K
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
-
R
P
E
D
A
G
D
V
F
N
T
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
V
K
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
---
I
G
L
V
D
E
L
V
A
T
--
V
E
E
L
V
P
A
A
K
A
W
I
K
E
--
E
L
K
A
N
P
-
D
G
A
G
V
Q
P
W
D
K
-
K
-----
G
Y
K
M
P
G
G
T
P
S
S
P
G
L
A
A
--
I
L
P
S
F
P
S
N
L
R
K
Q
L
K
G
--
A
P
-
M
P
A
P
R
A
I
L
A
A
A
----
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
-
F
F
D
L
Q
---
A
I
N
A
G
G
S
R
P
----
E
-
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
-
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
-
G
Y
S
E
K
L
----
E
A
K
A
L
E
R
--
G
-----
R
T
T
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
D
A
A
D
-
F
-
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
-
P
L
V
E
I
I
K
G
E
K
-
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
L
A
M
L
G
E
G
V
E
P
A
S
I
E
Q
A
G
S
Q
----
A
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
I
A
V
A
T
R
K
G
V
E
D
----------
A
G
G
---------
T
Y
Q
P
H
P
A
E
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
---------
A
D
G
K
R
--
S
G
L
W
P
G
L
--
R
---
E
T
F
--------
K
S
--
G
S
S
------
Q
P
P
L
--------
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
Y
S
G
P
A
G
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
Y
G
--
D
R
F
L
P
P
E
S
L
L
-----------
126
Fugue
69.96
32%
-72
- C2 -
1WDK
4
FADB_PSEFR
A:
[1-715]
MI
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
-
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
---
V
S
A
V
D
A
V
V
-
T
--
A
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
---------
G
E
L
D
Y
K
A
-
K
-----
R
Q
P
K
L
E
K
L
K
L
N
A
I
E
Q
M
--
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
G
--
P
N
-
Y
P
A
P
V
E
A
I
K
T
I
----
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
Q
E
L
---
K
K
K
A
K
V
Y
-
D
----
K
-
I
A
--
K
D
V
K
Q
A
A
V
L
G
A
G
I
M
-
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
-
A
E
A
A
K
L
----
L
V
G
R
V
D
K
--
G
-----
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
-
P
L
V
E
V
I
R
G
E
K
-
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
----
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
R
M
----------
K
---------
D
D
R
R
----
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
---------
E
K
K
L
V
--
D
S
S
V
L
E
V
--
L
---
K
P
I
--------
V
Y
--
E
Q
R
------
D
V
T
D
--------
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
D
S
I
------
G
V
A
E
F
V
A
L
A
D
Q
Y
A
E
L
-
G
--
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
GQSFFG
25
PsiBlast_CBE
66.10
33%
-67
- C2 -
1WDK
3
FADB_PSEFR
B:
[16-691]
---------------
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
---
V
S
A
V
D
A
V
V
-
T
--
A
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
L
-
D
Y
K
-
A
K
R
Q
P
K
L
E
-
K
LKLN-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
GQ
A
G
P
N
Y
P
-----------
A
P
-
V
E
A
I
K
T
I
Q
K
A
A
----
N
F
G
R
----
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
-
A
S
N
C
L
I
G
L
F
L
N
D
Q
E
---
L
K
K
K
A
K
V
-
Y
----
D
-
K
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
-
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
-
A
E
A
A
K
L
----
L
V
G
R
V
D
K
--
G
-----
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
-
P
L
V
E
V
I
R
G
E
K
-
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
----
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
----------
R
M
K
---------
D
D
R
R
----
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
----------
E
A
D
------
Q
K
K
L
--
V
---
D
S
S
--------
V
L
--
E
V
L
------
K
P
I
V
YEQRDVTD
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
---------------------------
22
PsiBlast_CBE
65.86
33%
-69
- C2 -
2D3T
1
FADB_PSEFR
B:
[16-691]
---------------
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
---
V
S
A
V
D
A
V
V
-
T
--
A
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
L
-
D
Y
K
-
A
K
R
Q
P
K
L
E
-
K
LKLN-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
GQ
A
G
P
N
Y
P
-----------
A
P
-
V
E
A
I
K
T
I
Q
K
A
A
----
N
F
G
R
----
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
-
A
S
N
C
L
I
G
L
F
L
N
D
Q
E
---
L
K
K
K
A
K
V
-
Y
----
D
-
K
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
-
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
-
A
E
A
A
K
L
----
L
V
G
R
V
D
K
--
G
-----
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
-
P
L
V
E
V
I
R
G
E
K
-
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
----
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
----------
R
M
K
---------
D
D
R
R
----
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
----------
E
A
D
------
Q
K
K
L
--
V
---
D
S
S
--------
V
L
--
E
V
L
------
K
P
I
V
YEQRDVTD
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
---------------------------
24
PsiBlast_CBE
65.82
33%
-66
* C1 *
1WDL
2
FADB_PSEFR
B:
[16-691]
---------------
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
---
V
S
A
V
D
A
V
V
-
T
--
A
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
L
-
D
Y
K
-
A
K
R
Q
P
K
L
E
-
K
LKLN-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
GQ
A
G
P
N
Y
P
-----------
A
P
-
V
E
A
I
K
T
I
Q
K
A
A
----
N
F
G
R
----
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
-
A
S
N
C
L
I
G
L
F
L
N
D
Q
E
---
L
K
K
K
A
K
V
-
Y
----
D
-
K
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
-
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
-
A
E
A
A
K
L
----
L
V
G
R
V
D
K
--
G
-----
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
-
P
L
V
E
V
I
R
G
E
K
-
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
----
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
----------
R
M
K
---------
D
D
R
R
----
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
---------------------
K
L
--
V
---
D
S
S
--------
V
L
--
E
V
L
------
K
P
I
V
YEQRDVTD
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
---------------------------
23
PsiBlast_CBE
65.75
33%
-68
- C2 -
1WDM
1
FADB_PSEFR
B:
[16-691]
---------------
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
---
V
S
A
V
D
A
V
V
-
T
--
A
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
L
-
D
Y
K
-
A
K
R
Q
P
K
L
E
-
K
LKLN-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
GQ
A
G
P
N
Y
P
-----------
A
P
-
V
E
A
I
K
T
I
Q
K
A
A
----
N
F
G
R
----
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
-
A
S
N
C
L
I
G
L
F
L
N
D
Q
E
---
L
K
K
K
A
K
V
-
Y
----
D
-
K
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
-
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
-
A
E
A
A
K
L
----
L
V
G
R
V
D
K
--
G
-----
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
-
P
L
V
E
V
I
R
G
E
K
-
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
----
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
----------
R
M
K
---------
D
D
R
R
----
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
----------
E
-------
K
Q
K
K
L
--
V
---
D
S
S
--------
V
L
--
E
V
L
------
K
P
I
V
YEQRDVTD
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
---------------------------
5
PsiBlast_PDB
65.45
33%
-68
- C2 -
1WDM
3
FADB_PSEFR
A:
[16-691]
---------------
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
---
V
S
A
V
D
A
V
V
-
T
--
A
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
L
-
D
Y
K
-
A
K
R
Q
P
K
L
E
-
K
LKLN-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
G
P
N
Y
P
-----------
A
P
-
V
E
A
I
K
T
I
Q
K
A
A
----
N
F
G
R
----
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
-
A
S
N
C
L
I
G
L
F
L
N
D
Q
E
---
L
K
K
K
A
K
V
-
Y
----
D
-
K
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
-
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
-
A
E
A
A
K
L
----
L
V
G
R
V
D
K
--
G
-----
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
-
P
L
V
E
V
I
R
G
E
K
-
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
----
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
----------
R
M
K
---------
D
D
R
R
----
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
--------------------
K
K
L
--
V
---
D
S
S
--------
V
L
--
E
V
L
------
K
P
I
V
YEQ
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
---------------------------
108
HHSearch
65.14
25%
-76
- C2 -
3ZWC
5
ECHP_RAT
A:
[23-718]
--------
E
Y
L
R
L
P
H
S
L
A
M
I
R
L
C
N
P
P
--
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
-
D
H
T
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
S
A
F
-
T
P
---------
G
L
A
L
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
--
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
L
-
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
---
L
G
I
L
D
A
V
V
K
S
--
D
-
P
V
-
E
E
A
I
K
F
A
Q
K
--
I
I
-------
D
--
K
P
I
E
P
R
R
IFNKP
V
P
S
L
P
N
M
---
D
S
------
V
F
A
E
A
I
A
K
V
R
K
Q
Y
----
P
G
-
V
L
A
P
E
T
C
V
R
S
I
----
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
-
F
A
E
K
S
---
A
N
K
W
S
T
P
-
S
GASW
K
-
T
A
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
-
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
-
K
I
I
T
F
T
----
L
E
K
E
A
S
R
--
A
-----
H
Q
N
G
Q
A
--
S
A
K
P
K
L
R
F
S
S
S
T
K
E
-
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
-
R
L
L
E
V
I
P
S
R
Y
-
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
S
K
P
E
D
V
D
G
V
L
E
E
----
F
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
G
L
T
G
P
S
L
P
P
GTPVRK
R
G
N
S
---------
R
Y
-
S
----
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
---------
D
K
P
L
G
RI
H
K
P
D
P
W
L
--
S
T
F
L
S
Q
Y
R
E
------
V
H
HI
E
Q
R
------
T
I
S
K
--------
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
A
S
V
------
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
DI
P
Q
L
E
P
S
D
Y
L
R
-----------
4
PsiBlast_PDB
64.76
33%
-65
- C2 -
1WDL
4
FADB_PSEFR
A:
[16-691]
---------------
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
D
A
-
S
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
D
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
---
V
S
A
V
D
A
V
V
-
T
--
A
D
K
L
G
A
A
A
L
D
L
I
K
R
A
I
S
G
E
L
-
D
Y
K
-
A
K
R
Q
P
K
L
E
-
K
LKLN-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
G
P
N
Y
P
-----------
A
P
-
V
E
A
I
K
T
I
Q
K
A
A
----
N
F
G
R
----
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
-
A
S
N
C
L
I
G
L
F
L
N
D
Q
E
---
L
K
K
K
A
K
V
-
Y
----
D
-
K
I
A
K
D
-
V
K
Q
A
A
V
L
G
A
G
I
M
-
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
-
A
E
A
A
K
L
----
L
V
G
R
V
D
K
--
G
-----
R
M
T
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
S
Y
G
D
-
F
-
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
-
P
L
V
E
V
I
R
G
E
K
-
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
A
K
L
V
S
A
G
V
D
F
V
R
I
D
K
V
M
E
K
----
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
G
R
D
V
M
A
E
G
F
P
D
----------
R
M
K
---------
D
D
R
R
----
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
----------
E
A
D
K
--
K
G
K
Q
K
K
L
--
V
---
D
S
S
--------
V
L
--
E
V
L
------
K
P
I
V
YEQ
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
I
G
V
A
E
F
V
A
L
A
D
Q
Y
A
---------------------------
106
HHSearch
64.42
29%
-71
- C2 -
2WTB
-
MFP2_ARATH
A:
[8-705]
------
K
T
V
M
E
V
G
G
D
G
V
A
V
I
T
L
I
N
P
P
--
V
N
S
L
S
F
D
V
L
Y
N
L
K
S
N
Y
E
E
A
L
S
-
R
N
D
V
K
A
I
V
I
T
G
A
-
K
G
R
F
S
G
G
F
D
I
-------------
E
P
K
A
G
Y
I
S
I
D
I
I
T
D
L
L
E
A
A
R
K
P
S
V
A
A
I
D
G
L
A
L
G
G
G
L
E
L
A
M
A
C
H
A
R
I
S
A
--
P
A
A
Q
L
G
L
P
E
L
Q
L
G
V
I
P
G
F
G
G
T
Q
R
L
P
R
L
V
G
L
T
K
A
L
-
E
M
I
L
T
S
K
P
V
K
A
E
E
G
H
S
---
L
G
L
I
D
A
V
V
P
P
--
A
-
E
L
V
T
T
A
R
R
W
A
L
D
--
I
V
-------
G
R
R
K
P
W
V
S
-
S
VSK--
T
D
K
L
P
P
L
G
E
A
R
-
E
-----
I
L
T
F
A
K
A
Q
T
L
K
R
-
A
P
---
N
-
M
K
H
P
L
M
C
L
D
A
I
----
E
V
G
I
V
S
G
P
R
A
G
L
E
K
E
A
E
V
A
S
Q
V
V
K
L
D
T
T
K
G
L
I
H
V
F
-
F
S
Q
R
G
---
T
A
K
V
P
G
V
-
T
----
D
R
G
L
V
P
R
K
I
K
K
V
A
I
I
G
G
G
L
M
-
G
S
G
I
A
T
A
L
I
L
S
N
Y
P
V
I
L
K
E
V
N
E
K
F
L
E
A
G
I
-
G
R
V
K
A
N
----
L
Q
S
R
V
R
-----------
S
Q
E
K
F
E
K
T
M
S
L
L
K
G
S
L
D
Y
E
S
-
F
-
R
D
V
D
M
V
I
E
A
V
I
E
N
I
S
L
K
Q
Q
I
F
A
D
L
E
K
Y
C
P
Q
H
C
I
L
A
S
N
T
S
T
I
D
L
N
K
I
G
E
R
T
K
S
Q
D
R
I
V
G
A
H
F
F
S
P
A
H
I
M
-
P
L
L
E
I
V
R
T
N
H
-
T
S
A
Q
V
I
V
D
L
L
D
V
G
K
K
I
K
K
T
P
V
V
V
G
N
C
T
G
F
A
V
N
R
M
F
F
P
Y
T
Q
A
A
M
F
L
V
E
C
G
A
D
P
Y
L
I
D
R
A
I
S
K
----
F
G
--
M
P
M
G
P
F
R
L
C
D
L
V
G
F
G
V
A
I
A
T
A
T
Q
F
I
E
N
F
------------
S
E
R
---------
T
Y
K
S
----
M
I
I
P
L
M
Q
E
D
K
--------------------------------
D
P
E
L
KK
Y
---
I
E
K
A
R
S
I
S
GV
K
L
D
P
-
K
L
A
------
N
L
S
E
--------
K
D
I
I
E
M
T
F
F
P
V
V
N
E
A
C
R
V
F
A
E
G
I
A
V
K
A
A
D
L
D
I
A
G
I
M
G
M
G
F
P
P
Y
R
G
G
I
M
F
W
A
D
S
I
------
G
S
K
Y
I
Y
S
R
L
D
E
W
S
K
A
Y
G
--
E
F
F
K
P
C
A
F
L
A
-----------
6
PsiBlast_PDB
63.05
29%
-73
- C2 -
2WTB
-
MFP2_ARATH
A:
[16-700]
--------------
D
G
V
A
V
I
T
L
I
N
P
P
--
V
N
S
L
S
F
D
V
L
Y
N
L
K
S
N
Y
E
E
A
L
S
R
N
D
-
V
K
A
I
V
I
T
G
A
K
G
-
R
F
S
G
G
F
D
I
-------------
E
P
K
A
G
Y
I
S
I
D
I
I
T
D
L
L
E
A
A
R
K
P
S
V
A
A
I
D
G
L
A
L
G
G
G
L
E
L
A
M
A
C
H
A
R
I
S
A
--
P
A
A
Q
L
G
L
P
E
L
Q
L
G
V
I
P
G
F
G
G
T
Q
R
L
P
R
L
V
G
L
T
K
A
L
E
M
I
L
T
S
----
K
P
V
K
A
E
E
G
H
S
L
G
L
I
D
A
V
V
P
P
--
A
E
-
L
V
T
T
A
R
R
W
A
L
D
I
V
G
R
R
---------
K
P
W
V
S
-
S
-----
V
S
K
----
T
D
K
L
P
P
L
G
E
--
A
R
E
I
L
T
F
A
K
A
Q
T
L
K
R
--
A
P
N
M
K
H
P
L
M
C
L
D
A
I
E
V
G
I
V
S
G
P
R
A
G
L
E
K
E
A
E
V
A
S
Q
----
V
V
K
L
D
T
T
K
G
L
I
H
V
F
F
S
Q
R
G
T
---
A
K
V
P
G
V
T
-
D
----
R
-
G
L
V
P
R
K
I
K
K
V
A
I
I
G
G
G
L
M
-
G
S
G
I
A
T
A
L
I
L
S
N
Y
P
V
I
L
K
E
V
N
E
K
F
L
E
A
G
I
-
G
R
V
K
A
N
----
L
Q
S
R
V
R
-----------
S
Q
E
K
F
E
K
T
M
S
L
L
K
G
S
L
D
Y
E
S
-
F
-
R
D
V
D
M
V
I
E
A
V
I
E
N
I
S
L
K
Q
Q
I
F
A
D
L
E
K
Y
C
P
Q
H
C
I
L
A
S
N
T
S
T
I
D
L
N
K
I
G
E
R
T
K
S
Q
D
R
I
V
G
A
H
F
F
S
P
A
H
I
M
-
P
L
L
E
I
V
R
T
N
H
-
T
S
A
Q
V
I
V
D
L
L
D
V
G
K
K
I
K
K
T
P
V
V
V
G
N
C
T
G
F
A
V
N
R
M
F
F
P
Y
T
Q
A
A
M
F
L
V
E
C
G
A
D
P
Y
L
I
D
R
A
I
S
K
----
F
G
--
M
P
M
G
P
F
R
L
C
D
L
V
G
F
G
V
--
A
I
A
T
A
T
Q
F
I
E
N
F
S
E
R
------
T
Y
K
-------------
S
----
M
I
I
P
L
M
Q
E
D
K
--------------------------------
D
P
E
L
--
K
---
K
Y
I
--------
E
K
--
A
R
S
I
S
GV
K
L
D
P
K
L
ANLS
E
---
K
D
I
I
E
M
T
F
F
P
V
V
N
E
A
C
R
V
F
A
E
G
I
A
V
K
A
A
D
L
D
I
A
G
I
M
G
M
G
F
P
P
Y
R
G
G
----
I
M
F
W
A
D
S
I
G
S
--
K
Y
I
Y
S
R
L
D
E
W
S
K
A
Y
G
--
E
F
F
K
P
----------------
10
PsiBlast_PDB
62.40
28%
-76
- C2 -
3ZWC
5
ECHP_RAT
A:
[63-681]
---------------------------------------------------
H
T
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
S
A
F
-
T
P
G
L
A
--
L
G
S
L
V
D
E
I
Q
R
-------
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
--
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
---
L
G
I
L
D
A
V
V
K
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
E
P
--------------
R
-
R
-----
I
F
N
K
P
--
V
P
S
L
P
N
M
D
S
--
V
F
A
E
A
I
A
K
V
R
K
Q
Y
P
G
V
L
A
P
-
E
T
C
V
R
S
I
Q
A
S
V
--------
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
K
S
A
NKW
S
T
P
S
G
A
S
-
W
----
K
-
T
A
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
-
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
----
A
V
E
S
D
P
K
Q
L
-
D
A
A
K
K
I
----
I
T
F
T
L
E
K
E
A
S
-----
R
A
H
Q
N
G
Q
A
S
A
K
P
K
L
R
F
S
S
S
T
K
E
-
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
-
R
L
L
E
V
I
P
S
R
Y
-
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
S
K
P
E
D
V
D
G
V
L
E
E
----
F
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
----
R
K
G
Q
G
L
T
G
P
------
S
L
P
P
GTPVRKRGN
S
R
Y
S
----
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
DKPLGRIHK
P
D
P
W
L
--
S
T
F
L
S
Q
Y
--
R
---
E
V
H
--------
H
I
--
E
Q
R
------
T
I
S
K
--------
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
------------------------------------------------------
8
PsiBlast_PDB
62.21
28%
-74
- C2 -
3ZW9
3
ECHP_RAT
A:
[63-681]
---------------------------------------------------
H
T
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
S
A
F
-
T
P
G
L
A
--
L
G
S
L
V
D
E
I
Q
R
-------
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
--
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
---
L
G
I
L
D
A
V
V
K
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
E
P
--------------
R
-
R
-----
I
F
N
K
P
--
V
P
S
L
P
N
M
D
S
--
V
F
A
E
A
I
A
K
V
R
K
Q
Y
P
G
VL
A
P
-
E
T
C
V
R
S
I
Q
A
S
V
--------
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
K
S
A
NKW
S
T
P
S
G
A
S
-
W
----
K
-
T
A
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
-
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
----
A
V
E
S
D
P
K
Q
L
-
D
A
A
K
K
I
----
I
T
F
T
L
E
K
E
A
S
-----
R
A
H
Q
N
G
Q
A
S
A
K
P
K
L
R
F
S
S
S
T
K
E
-
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
-
R
L
L
E
V
I
P
S
R
Y
-
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
S
K
P
E
D
V
D
G
V
L
E
E
----
F
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
----
R
K
G
Q
G
L
T
G
P
------
S
L
P
P
GTPVRKRGN
S
R
Y
S
----
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
DKPLGRIHK
P
D
P
W
L
--
S
T
F
L
S
Q
Y
--
R
---
E
V
H
--------
H
I
--
E
Q
R
------
T
I
S
K
--------
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
------------------------------------------------------
11
PsiBlast_PDB
62.12
28%
-78
- C2 -
2X58
6
ECHP_RAT
A:
[48-666]
---------------------------------------------------
H
T
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
S
A
F
-
T
P
G
L
A
--
L
G
S
L
V
D
E
I
Q
R
-------
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
--
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
---
L
G
I
L
D
A
V
V
K
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
E
P
--------------
R
-
R
-----
I
F
N
K
P
--
V
P
S
L
P
N
M
D
S
--
V
F
A
E
A
I
A
K
V
R
K
Q
Y
P
G
VL
A
P
-
E
T
C
V
R
S
I
Q
A
S
V
--------
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
K
S
A
NKW
S
T
P
S
G
A
S
-
W
----
K
-
T
A
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
-
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
----
A
V
E
S
D
P
K
Q
L
-
D
A
A
K
K
I
----
I
T
F
T
L
E
K
E
A
S
-----
R
A
H
Q
N
G
Q
A
S
A
K
P
K
L
R
F
S
S
S
T
K
E
-
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
-
R
L
L
E
V
I
P
S
R
Y
-
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
S
K
P
E
D
V
D
G
V
L
E
E
----
F
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
----
R
K
G
Q
G
L
T
G
P
------
S
L
P
P
GTPVRKRGN
S
R
Y
S
----
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
DKPLGR
I
H
K
P
D
P
W
L
--
S
T
F
L
S
Q
Y
--
R
---
E
V
H
--------
H
I
--
E
Q
R
------
T
I
S
K
--------
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
------------------------------------------------------
12
PsiBlast_PDB
62.11
28%
-76
- C2 -
3ZWB
2
ECHP_RAT
A:
[63-681]
---------------------------------------------------
H
T
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
S
A
F
-
T
P
G
L
A
--
L
G
S
L
V
D
E
I
Q
R
-------
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
--
A
K
A
R
V
G
L
P
A
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
---
L
G
I
L
D
A
V
V
K
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
E
P
--------------
R
-
R
-----
I
F
N
K
P
--
V
P
S
L
P
N
M
D
S
--
V
F
A
E
A
I
A
K
V
R
K
Q
Y
P
G
V
L
A
P
-
E
T
C
V
R
S
I
Q
A
S
V
--------
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
K
S
A
N
K
W
S
T
P
S
G
A
S
-
W
----
K
-
T
A
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
-
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
----
A
V
E
S
D
P
K
Q
L
-
D
A
A
K
K
I
----
I
T
F
T
L
E
K
E
A
S
-----
R
A
H
Q
N
G
Q
A
S
A
K
P
K
L
R
F
S
S
S
T
K
E
-
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
-
R
L
L
E
V
I
P
S
R
Y
-
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
S
K
P
E
D
V
D
G
V
L
E
E
----
F
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
----
R
K
G
Q
G
L
T
G
P
------
S
L
P
P
GTPVRKRGN
S
R
Y
S
----
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
DKPLGR
I
H
K
P
D
P
W
L
--
S
T
F
L
S
Q
Y
--
R
---
E
V
H
--------
H
I
--
E
Q
R
------
T
I
S
K
--------
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
------------------------------------------------------
7
PsiBlast_PDB
61.88
28%
-75
- C2 -
3ZW8
5
ECHP_RAT
A:
[63-681]
---------------------------------------------------
H
T
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
S
A
F
-
T
P
G
L
A
--
L
G
S
L
V
D
E
I
Q
R
-------
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
--
A
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
---
L
G
I
L
D
A
V
V
K
S
D
P
V
E
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
E
P
--------------
R
-
R
-----
I
F
N
K
P
--
V
P
S
L
P
N
M
D
S
--
V
F
A
E
A
I
A
K
V
R
K
Q
Y
P
G
V
L
A
P
-
E
T
C
V
R
S
I
Q
A
S
V
--------
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
K
S
A
NKW
S
T
P
S
G
A
S
-
W
----
K
-
T
A
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
-
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
----
A
V
E
S
D
P
K
Q
L
-
D
A
A
K
K
I
----
I
T
F
T
L
E
K
E
A
S
-----
R
A
H
Q
N
G
Q
A
S
A
K
P
K
L
R
F
S
S
S
T
K
E
-
L
-
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
-
R
L
L
E
V
I
P
S
R
Y
-
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
S
K
P
E
D
V
D
G
V
L
E
E
----
F
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
----
R
K
G
Q
G
L
T
G
P
------
S
L
P
P
GTPVRKRGN
S
R
Y
S
----
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
DKPLGR
I
H
K
P
D
P
W
L
--
S
T
F
L
S
Q
Y
--
R
---
E
V
H
--------
H
I
--
E
Q
R
------
T
I
S
K
--------
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
------------------------------------------------------
56
PsiBlast_CBE
44.92
34%
-70
- C2 -
1F17
1
HCDH_HUMAN
B:
[12-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
V
K
H
V
T
V
I
G
G
G
L
M
-
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
RKVA
K
K
K
F
A
E
N
--
P
-----
K
A
G
D
E
C
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
-
K
L
V
E
V
I
K
T
P
M
-
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
--
D
A
S
K
E
D
I
D
T
A
MKLG
A
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
-
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
------
L
H
Q
P
---------
S
P
S
-------
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
44.22
34%
-71
- C2 -
3HDH
1
HCDH_PIG
A:
[12-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
L
V
K
H
V
T
V
I
G
G
G
L
M
-
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
--
P
-----
K
A
G
D
E
F
V
E
K
T
L
S
S
I
S
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
-
K
L
V
E
V
V
K
T
P
M
-
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
--
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
-
K
F
I
I
D
G
W
H
E
M
D
S
Q
N
P
------
L
F
Q
P
---------
S
P
A
-------
M
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
44.11
34%
-70
- C2 -
1M75
3
HCDH_HUMAN
B:
[12-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
V
K
H
V
T
V
I
G
G
G
L
M
-
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
RKVA
K
K
K
F
A
E
N
--
P
-----
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
-
K
L
V
E
V
I
K
T
P
M
-
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
--
D
A
S
K
E
D
I
D
T
A
MKLG
A
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
-
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
------
L
H
Q
P
---------
S
P
S
-------
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
43.78
34%
-72
- C2 -
1F17
1
HCDH_HUMAN
A:
[12-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
V
K
H
V
T
V
I
G
G
G
L
M
-
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
--
P
-----
K
A
G
D
E
C
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
-
K
L
V
E
V
I
K
T
P
M
-
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
--
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
-
K
F
I
V
D
G
W
H
E
M
D
A
E
N
P
------
L
H
Q
P
---------
S
P
S
-------
L
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
43.58
34%
-69
- C2 -
3HDH
1
HCDH_PIG
B:
[12-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
L
V
K
H
V
T
V
I
G
G
G
L
M
-
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
RKVA
K
K
K
F
A
E
N
--
P
-----
K
A
G
D
E
F
V
E
K
T
L
S
S
I
S
T
S
T
D
A
A
S
-
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
-
K
L
V
E
V
V
K
T
P
M
-
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
--
D
A
S
K
E
D
I
D
T
A
MKLG
A
G
--
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
-
K
F
I
I
D
G
W
H
E
M
D
S
Q
N
P
------
L
F
Q
P
---------
S
P
A
-------
M
N
K
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
40.93
35%
-64
- C2 -
4KUG
1
?
A:
[1-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
K
V
F
V
L
G
A
G
T
M
-
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
-
A
T
I
T
K
S
----
L
S
K
L
V
A
K
--
E
-----
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
-
A
-
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
-
K
L
V
E
V
I
R
G
A
A
-
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
----
L
G
AN
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
----
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
------
D
T
K
----------
Y
R
A
S
----
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
---------
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
40.21
35%
-59
- C2 -
4KUG
1
?
D:
[1-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
K
V
F
V
L
G
A
G
T
M
-
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
-
A
T
I
T
K
S
----
L
S
K
L
V
A
K
--
E
-----
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
-
A
-
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
-
K
L
V
E
V
I
R
G
A
A
-
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
----
L
G
AN
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
----
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
------
D
T
K
----------
Y
R
A
S
----
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
---------
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
40.15
35%
-61
- C2 -
4KUG
1
?
B:
[1-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
K
V
F
V
L
G
A
G
T
M
-
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
-
A
T
I
T
K
S
----
L
S
K
L
V
A
K
--
E
-----
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
-
A
-
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
-
K
L
V
E
V
I
R
G
A
A
-
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
----
L
G
AN
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
----
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
------
D
T
K
----------
Y
R
A
S
----
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
---------
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
40.15
35%
-61
- C2 -
4KUG
1
?
C:
[1-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
K
V
F
V
L
G
A
G
T
M
-
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
-
A
T
I
T
K
S
----
L
S
K
L
V
A
K
--
E
-----
K
I
T
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
D
M
K
L
-
A
-
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
-
K
L
V
E
V
I
R
G
A
A
-
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
----
L
G
AN
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
----
V
C
L
A
I
M
D
V
L
Y
N
E
T
G
------
D
T
K
----------
Y
R
A
S
----
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
---------
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
130
Fugue
37.17
36%
-75
* C2 *
2HDH
1
HCDH_HUMAN
A:
[1-192]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
V
K
H
V
T
V
I
G
G
G
L
-
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
-
K
G
I
E
E
S
----
L
R
K
V
A
K
K
--
K
F
A
EN
P
K
A
G
D
E
F
V
A
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
V
-
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
-
P
V
M
K
L
V
E
V
I
K
T
-
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------