@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0946c: (2016-04-27 )
MTSAPIPDITATPAWDALRRHHDQIGNTHLRQFFADDPGRGRELTVSVGDLYIDYSKHRVTRETLALLIDLARTAHLEERRDQMFAGVHINTSEDRAVLHTALRLPRDAELVVDGQDVVTDVHAVLDAMGAFTDRLRSGEWTGATGKRISTVVNIGIGGSDLGPVMVYQALRHYADAGISARFVSNVDPADLIATLADLDPATTLFIVASKTFSTLETLTNATAARRWLTDALGDAAVSRHFVAVSTNKRLVDDFGINTDNMFGFWDWVGGRYSVDSAIGLSLMTVIGRDAFADFLAGFHIIDRHFATAPLESNAPVLLGLIGLWYSNFFGAQSRTVLPYSNDLSRFPAYLQQLTMESNGKSTRADGSPVSADTGEIFWGEPGTNGQHAFYQLLHQGTRLVPADFIGFAQPLDDLPTAEGTGSMHDLLMSNFFAQTQVLAFGKTAEEIAADGTPAHVVAHKVMPGNRPSTSILASRLTPSVLGQLIALYEHQVFTEGVVWGIDSFDQWGVELGKTQAKALLPVITGAGSPPPQSDSSTDGLVRRYRTERGRAG
Atome Classification :
(55 SA)
---------------------------------------------.........10........20....-....-.30........40.......-------.-------50.........60........70........80........90........100.......110.-.......120.......130.......140.......150.......160.......170--....-----....180---..-.....190.......200.......210.......220......-.230..------.------.------.------.--..240.......250.......260.......270.......280-......-..290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......---410.......-420.......430.......440....----.----.-----.450--------.--------..--------.---------.---------...460.......470.......480.......490.......500.......510.......520....--...-------530..-.....540.......550.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------MTSAPIPDITATP
A
W
D
A
L
R
R
-
H
H
D
Q-I
G
N
T
-
H
L
R
Q
F
FADDPGRG
R
E
L
T
V
S
V
-------
G
-------
D
-
L
Y
I
DYSKH
R
V
T
R
E
T
L
A
L
L
I
D
L
A
R
T
A
H
L
E
E
R
R
D
Q
M
F
A
G
V
H
I
NTSE
D
R
A
V
L
H
T
A
LRLPRD
A
E
L
-
V
-VD
G
Q
D
V
V
T
D
V
H
A
V
L
D
A
M
G
A
F
T
D
R
LRSGEWTGATG
K
R
I
S
T
V
V
N
IGIGGSD
L
G
P
V
M
V
Y
Q
A
L
---
R
H
Y
A
-----DAGI
S
A
R
---FV-SNV
D
P
A
D
L
I
A
T
L
ADLDPA
T
T
L
F
I
V
ASK
T
F
S
T
L
E
T
L
T
N
A
T
A
A
R
R
W
-
L
T
D
-
A
L
------
G
------
D
------
A
------
A
--
V
S
R
H
F
V
A
VSTNKR
L
V
D
DFGINTDN
M
F
G
F
W
DWVGGRYSV
D
S
A
I
G
-
L
-
S
L
M
T
V
I
-
G
R
D
A
F
A
D
F
L
A
G
F
H
I
I
D
R
H
FATAPLESNAP
V
L
L
G
L
I
G
L
W
Y
S
N
FFGAQS
R
T
V
LPYSN
D
L
S
R
F
P
A
Y
L
Q
Q
L
T
MESNGKSTRADGSPVSADTG
E
I
FWGEPGTN
G
Q
H
A
F
Y
Q
L
L
HQGTRLV
P
A
D
F
IGFA---Q
P
L
D
DLPTAE-GT
G
S
M
H
D
L
L
M
S
N
F
F
A
Q
T
Q
V
LAFGK
T
A
E
----
E
----I-----AAD---------G--------T
P
--------
A
---------
H
---------
V
V
A
H
KVMPGNRP
S
T
S
I
L
A
S
RL
T
P
S
V
L
G
Q
L
I
A
L
Y
E
H
Q
V
FTEGVVWGID
S
F
D
Q
W
G
V
ELGK
T
Q
A
K
A
L
L
P
V
ITG--AGS-------PPPQS-DS
S
T
D
G
L
V
R
R
Y
R
T
ERGRAG
1
PsiBlast_PDB
100.00
99%
-108
- C6 -
2WU8
2
G6PI_MYCTU
A:
[1-547]
---------------------------------------------------
P
D
I
T
A
T
P
A
W
D
A
L
A
R
-
H
H
D
Q
-
I
G
N
T
-
H
L
R
Q
F
F
A
D
D
P
G
R
G
R
E
L
T
V
S
V
-------
G
-------
D
-
L
Y
I
D
Y
S
K
H
R
V
T
R
E
T
L
A
L
L
I
D
L
A
R
T
A
H
L
E
E
R
R
D
Q
M
F
A
G
V
H
I
N
T
S
E
D
R
A
V
L
H
T
A
L
R
L
P
R
D
A
E
L
-
V
-
V
D
G
Q
D
V
V
T
D
V
H
A
V
L
D
A
M
G
A
F
T
D
R
L
R
S
G
E
W
T
G
A
T
G
K
R
I
S
T
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
V
Y
Q
A
L
---
R
H
Y
A
-----
D
A
G
I
S
A
R
---
F
V
-
S
N
V
D
P
A
D
L
I
A
T
L
A
D
L
D
P
A
T
T
L
F
I
V
A
S
K
T
F
S
T
L
E
T
L
T
N
A
T
A
A
R
R
W
-
L
T
D
-
A
L
------
G
------
D
------
A
------
A
--
V
S
R
H
F
V
A
V
S
T
N
K
R
L
V
D
D
F
G
I
N
T
D
N
M
F
G
F
W
D
W
V
G
G
R
Y
S
V
D
S
A
I
G
-
L
-
S
L
M
T
V
I
-
G
R
D
A
F
A
D
F
L
A
G
F
H
I
I
D
R
H
F
A
T
A
P
L
E
S
N
A
P
V
L
L
G
L
I
G
L
W
Y
S
N
F
F
G
A
Q
S
R
T
V
L
P
Y
S
N
D
L
S
R
F
P
A
Y
L
Q
Q
L
T
M
E
S
N
G
K
S
T
R
A
D
G
S
P
V
S
A
D
T
G
E
I
F
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
L
H
Q
G
T
R
L
V
P
A
D
F
I
G
F
A
---
Q
P
L
D
D
L
P
T
A
E
-
G
T
G
S
M
H
D
L
L
M
S
N
F
F
A
Q
T
Q
V
L
A
F
G
K
T
A
E
----
E
----
I
-----
A
A
D
---------
G
--------
T
P
--------
A
---------
H
---------
V
V
A
H
K
V
M
P
G
N
R
P
S
T
S
I
L
A
S
R
L
T
P
S
V
L
G
Q
L
I
A
L
Y
E
H
Q
V
F
T
E
G
V
V
W
G
I
D
S
F
D
Q
W
G
V
E
L
G
K
T
Q
A
K
A
L
L
P
V
I
T
G
--
A
G
S
-------
P
P
P
Q
S
-
D
S
S
T
D
G
L
V
R
R
Y
R
T
E
R
G
R
A
G
101
HHSearch
99.26
99%
-106
- C6 -
2WU8
2
G6PI_MYCTU
A:
[2-547]
----------------------------------------------------
D
I
T
A
T
P
A
W
D
A
L
A
R
-
H
H
D
Q
-
I
G
N
T
-
H
L
R
Q
F
F
A
D
D
P
G
R
G
R
E
L
T
V
S
V
-------
G
-------
D
-
L
Y
I
D
Y
S
K
H
R
V
T
R
E
T
L
A
L
L
I
D
L
A
R
T
A
H
L
E
E
R
R
D
Q
M
F
A
G
V
H
I
N
T
S
E
D
R
A
V
L
H
T
A
L
R
L
P
R
D
A
E
L
-
V
-
V
D
G
Q
D
V
V
T
D
V
H
A
V
L
D
A
M
G
A
F
T
D
R
L
R
S
G
E
W
T
G
A
T
G
K
R
I
S
T
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
V
Y
Q
A
L
---
R
H
Y
A
-----
D
A
G
I
S
A
R
---
F
V
-
S
N
V
D
P
A
D
L
I
A
T
L
A
D
L
D
P
A
T
T
L
F
I
V
A
S
K
T
F
S
T
L
E
T
L
T
N
A
T
A
A
R
R
W
-
L
T
D
-
A
L
------
G
------
D
------
A
------
A
--
V
S
R
H
F
V
A
V
S
T
N
K
R
L
V
D
D
F
G
I
N
T
D
N
M
F
G
F
W
D
W
V
G
G
R
Y
S
V
D
S
A
I
G
-
L
S
L
M
T
V
I
--
G
R
D
A
F
A
D
F
L
A
G
F
H
I
I
D
R
H
F
A
T
A
P
L
E
S
N
A
P
V
L
L
G
L
I
G
L
W
Y
S
N
F
F
G
A
Q
S
R
T
V
L
P
Y
S
N
D
L
S
R
F
P
A
Y
L
Q
Q
L
T
M
E
S
N
G
K
S
T
R
A
D
G
S
P
V
S
A
D
T
G
E
I
F
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
L
H
Q
G
T
R
L
V
P
A
D
F
I
G
F
A
---
Q
P
L
D
D
L
P
T
A
E
-
G
T
G
S
M
H
D
L
L
M
S
N
F
F
A
Q
T
Q
V
L
A
F
G
K
T
A
E
----
E
----
I
-----
A
A
D
---------
G
--------
T
P
--------
A
---------
H
---------
V
V
A
H
K
V
M
P
G
N
R
P
S
T
S
I
L
A
S
R
L
T
P
S
V
L
G
Q
L
I
A
L
Y
E
H
Q
V
F
T
E
G
V
V
W
G
I
D
S
F
D
Q
W
G
V
E
L
G
K
T
Q
A
K
A
L
L
P
V
I
T
G
--
A
G
S
-------
P
P
P
Q
S
-
D
S
S
T
D
G
L
V
R
R
Y
R
T
E
R
G
R
A
G
6
PsiBlast_PDB
85.70
49%
-102
- C6 -
1HM5
-
G6PI_RABIT
A:
[3-552]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
TNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
-
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
--------
E
D
L
M
------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
-
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
21
PsiBlast_CBE
85.29
51%
-100
- C6 -
3HJB
8
G6PI_VIBCH
D:
[32-573]
------------------------------------------------------
T
Q
T
Q
A
W
K
A
L
T
A
-
H
F
E
S
-
A
Q
D
M
-
D
L
K
A
L
F
A
Q
D
S
E
R
F
A
K
Y
S
A
R
F
-------
G
Q------
D
-
I
L
V
D
Y
S
K
N
L
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
T
D
L
Q
S
A
I
T
A
M
F
K
G
E
A
I
N
Q
T
E
D
R
A
V
L
H
T
A
L
R
N
R
S
N
S
P
V
-
L
-
V
N
G
E
D
V
M
P
A
V
N
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
G
E
W
K
G
F
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
---
V
P
Y
K
-----
N
H
-
L
T
V
H
---
F
V
-
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
D
W
-
F
L
K
-
A
A
------
G
------
D
------
E
------
A
H-
V
A
K
H
F
A
A
L
S
T
N
G
K
A
V
A
E
F
G
I
D
T
D
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
I
L
S
I
-
G
Y
D
N
F
V
E
L
L
A
G
A
H
E
M
D
Q
H
F
V
N
T
P
F
E
S
N
I
P
V
I
L
A
L
I
G
I
W
Y
N
N
F
H
G
A
E
S
E
A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
P
V
T
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
A
P
A
---------
V
S
H
N
-
L
V
G
D
H
H
Q
K
L
M
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
A
Q
----
A
----
V
-----
Q
A
E
LEKAGKSA-
A
--------
E
I
--------
A
---------
A
---------
L
V
P
F
K
V
F
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
D
--
S
A
A
-------
V
T
S
H
--
D
S
S
T
N
G
L
I
N
A
F
K
A
F
R
----
10
PsiBlast_PDB
85.25
49%
-102
- C6 -
1N8T
-
G6PI_RABIT
A:
[3-552]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
TNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
D
W
F
L
L
S
-
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
--------
E
D
L
M
------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
-
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
23
PsiBlast_CBE
85.20
51%
-100
- C6 -
3HJB
10
G6PI_VIBCH
B:
[32-573]
------------------------------------------------------
T
Q
T
Q
A
W
K
A
L
T
A
-
H
F
E
S
-
A
Q
D
M
-
D
L
K
A
L
F
A
Q
D
S
E
R
F
A
K
Y
S
A
R
F
-------
G
Q------
D
-
I
L
V
D
Y
S
K
N
L
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
T
D
L
Q
S
A
I
T
A
M
F
K
G
E
A
I
N
Q
T
E
D
R
A
V
L
H
T
A
L
R
N
R
S
N
S
P
V
-
L
-
V
N
G
E
D
V
M
P
A
V
N
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
G
E
W
K
G
F
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
---
V
P
Y
K
-----
N
H
-
L
T
V
H
---
F
V
-
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
D
W
-
F
L
K
-
A
A
------
G
------
D
------
E
------
A
H-
V
A
K
H
F
A
A
L
S
T
N
G
K
A
V
A
E
F
G
I
D
T
D
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
I
L
S
I
-
G
Y
D
N
F
V
E
L
L
A
G
A
H
E
M
D
Q
H
F
V
N
T
P
F
E
S
N
I
P
V
I
L
A
L
I
G
I
W
Y
N
N
F
H
G
A
E
S
E
A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
P
V
T
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
A
P
A
---------
V
S
H
N
-
L
V
G
D
H
H
Q
K
L
M
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
A
Q
----
A
----
V
-----
Q
A
E
LEKAGKSA-
A
--------
E
I
--------
A
---------
A
---------
L
V
P
F
K
V
F
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
D
--
S
A
A
-------
V
T
S
H
--
D
S
S
T
N
G
L
I
N
A
F
K
A
F
R
----
7
PsiBlast_PDB
85.18
49%
-100
- C6 -
1XTB
2
G6PI_RABIT
A:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
TNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
-
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
--------
E
D
L
M
------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
-
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
25
PsiBlast_CBE
85.15
49%
-100
- C6 -
1XTB
2
G6PI_RABIT
B:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
NTNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
-
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
RKELQ
A
A
G
---------
K
--------
S
P
--------
E
DLM------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
-
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
26
PsiBlast_CBE
85.12
49%
-98
- C6 -
1HOX
2
G6PI_RABIT
B:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
NTNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
-
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
RKELQ
A
A
G
---------
K
--------
S
P
--------
E
DLM------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
-
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
30
PsiBlast_CBE
84.91
53%
-99
- C6 -
4EM6
9
G6PI_BRUME
C:
[19-551]
--------------------------------------------------------------
L
K
K
-
H
W
A
E
-
S
A
P
R
-
D
M
R
A
A
F
S
A
D
P
G
R
F
G
R
Y
S
L
C
L
-------
D
-------
D
-
L
L
F
D
W
S
K
C
R
V
N
D
E
T
M
A
L
L
K
E
L
A
V
A
A
D
V
E
G
R
R
A
A
M
F
A
G
E
H
I
N
N
T
E
D
R
A
V
L
H
V
A
L
R
D
T
S
S
K
E
V
-
L
-
V
D
G
H
N
V
L
P
D
V
K
H
V
L
D
R
M
A
A
F
A
D
G
I
R
S
G
A
L
K
G
A
T
G
R
K
I
T
D
I
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
L
A
L
---
A
P
Y
H
-----
D
E
P
-
R
A
H
---
F
V
-
S
N
I
D
G
A
H
I
A
D
T
L
S
P
L
D
P
A
S
T
L
I
I
V
A
S
K
T
F
T
T
I
E
T
M
T
N
A
Q
T
A
R
K
W
-
V
A
D
-
T
L
------
G
------
E
------
A
------
A
--
V
G
A
H
F
A
A
V
S
T
A
L
D
K
V
A
A
F
G
I
P
E
D
R
V
F
G
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
I
G
-
L
-
P
V
M
I
A
V
-
G
P
D
N
F
R
K
F
L
A
G
A
H
A
M
D
V
H
F
R
D
A
P
L
E
K
N
L
P
V
M
L
G
L
I
G
Y
W
H
R
A
I
C
G
Y
G
S
R
A
I
I
P
Y
D
Q
R
L
S
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
S
V
T
L
D
G
K
P
V
S
G
P
T
G
P
V
V
W
G
E
P
G
T
N
G
Q
H
A
F
F
Q
L
L
H
Q
G
T
D
T
I
P
L
E
F
I
V
A
A
---
K
G
H
E
--
P
T
L
D
----
H
Q
H
E
M
L
M
A
N
C
L
A
Q
S
E
A
L
M
K
G
R
T
L
D
----
E
ARAQ
L
-----
Q
A
K
---------
N
--------
L
P
--------
A
SQVE-----
R
---------
I
A
P
H
R
V
F
S
G
N
R
P
S
L
T
L
I
H
D
M
L
D
P
Y
T
L
G
R
L
I
A
L
Y
E
H
R
V
F
V
E
A
Q
I
F
G
I
N
A
F
D
Q
W
G
V
E
L
G
K
E
L
A
T
E
L
L
P
V
V
S
G
--
K
E
G
-------
A
S
G
R
--
D
A
S
T
Q
G
L
V
A
H
L
H
A
R
R
----
59
PsiBlast_CBE
84.87
47%
-101
- C6 -
2O2D
3
G6PI_TRYBB
B:
[50-601]
-----------------------------------------------------
L
T
S
C
A
S
W
T
Q
L
Q
K
-
L
Y
E
Q
-
Y
G
D
E
-
P
I
K
K
H
F
E
T
D
S
E
R
G
Q
R
Y
S
V
K
V
S
LGSKDE
N
-------
F
-
L
F
L
D
Y
S
K
S
H
I
N
D
E
I
K
C
A
L
L
R
L
A
E
E
R
G
I
R
Q
F
V
Q
S
V
F
R
G
E
R
V
N
T
T
E
N
R
P
V
L
H
I
A
L
R
N
R
S
N
R
P
I
-
Y
-
V
D
G
K
D
V
M
P
A
V
N
K
V
L
D
Q
M
R
S
F
S
E
K
V
R
T
G
E
W
K
G
H
T
G
K
A
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
E
A
L
---
K
P
F
S
-----
Q
R
D
L
S
L
H
---
F
V
-
S
N
V
D
G
T
H
I
A
E
V
L
K
S
I
D
I
E
A
T
L
F
I
V
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
R
A
-
L
L
D
-
Y
L
R
S
R
GID
E
------
K
------
G
------
S
--
V
A
K
H
F
V
A
L
S
T
N
N
Q
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
M
W
S
A
I
G
-
L
-
P
I
M
I
S
I
-
G
Y
E
N
F
V
E
L
L
T
G
A
H
V
I
D
E
H
F
A
N
A
P
P
E
Q
N
V
P
L
L
L
A
L
V
G
V
W
Y
I
N
F
F
G
A
V
T
H
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
Y
V
T
R
S
G
K
T
V
S
T
L
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
N
L
I
P
C
D
F
I
G
A
I
---
Q
S
Q
N
K
I
-------
G
D
H
H
K
I
F
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
S
P
S
----
E
----
V
-----
R
R
E
---------
L
--------
E
A
--------
A
GERS
A
E
K
I
N
A
---------
L
L
P
H
K
T
F
I
G
G
R
P
S
N
T
L
L
I
K
S
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
D
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
R
---
P
G
M
-------
R
V
N
N
H
-
D
S
S
T
N
G
L
I
N
M
F
--------
60
PsiBlast_CBE
84.85
47%
-100
- C6 -
2O2D
2
G6PI_TRYBB
A:
[50-601]
-----------------------------------------------------
L
T
S
C
A
S
W
T
Q
L
Q
K
-
L
Y
E
Q
-
Y
G
D
E
-
P
I
K
K
H
F
E
T
D
S
E
R
G
Q
R
Y
S
V
K
V
S
LGSKDE
N
-------
F
-
L
F
L
D
Y
S
K
S
H
I
N
D
E
I
K
C
A
L
L
R
L
A
E
E
R
G
I
R
Q
F
V
Q
S
V
F
R
G
E
R
V
N
T
T
E
N
R
P
V
L
H
I
A
L
R
N
R
S
N
R
P
I
-
Y
-
V
D
G
K
D
V
M
P
A
V
N
K
V
L
D
Q
M
R
S
F
S
E
K
V
R
T
G
E
W
K
G
H
T
G
K
A
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
E
A
L
---
K
P
F
S
-----
Q
R
D
L
S
L
H
---
F
V
-
S
N
V
D
G
T
H
I
A
E
V
L
K
S
I
D
I
E
A
T
L
F
I
V
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
R
A
-
L
L
D
-
Y
L
R
S
R
GID
E
------
K
------
G
------
S
--
V
A
K
H
F
V
A
L
S
T
N
N
Q
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
M
W
S
A
I
G
-
L
-
P
I
M
I
S
I
-
G
Y
E
N
F
V
E
L
L
T
G
A
H
V
I
D
E
H
F
A
N
A
P
P
E
Q
N
V
P
L
L
L
A
L
V
G
V
W
Y
I
N
F
F
G
A
V
T
H
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
Y
V
T
R
S
G
K
T
V
S
T
L
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
N
L
I
P
C
D
F
I
G
A
I
---
Q
S
Q
N
K
I
-------
G
D
H
H
K
I
F
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
S
P
S
----
E
----
V
-----
R
R
E
---------
L
--------
E
A
--------
A
GERS
A
E
K
I
N
A
---------
L
L
P
H
K
T
F
I
G
G
R
P
S
N
T
L
L
I
K
S
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
D
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
R
---
P
G
M
-------
R
V
N
N
H
-
D
S
S
T
N
G
L
I
N
M
F
--------
24
PsiBlast_CBE
84.85
51%
-101
- C6 -
3NBU
1
G6PI_ECOLI
D:
[7-549]
------------------------------------------------------
T
Q
T
A
A
W
Q
A
L
Q
K
-
H
F
D
E
-
M
K
D
V
-
T
I
A
D
L
F
A
K
D
G
D
R
F
S
K
F
S
A
T
F
-------
D
-------
D
Q
M
L
V
D
Y
S
K
N
R
I
T
E
E
T
L
A
K
L
Q
D
L
A
K
E
C
D
L
A
G
A
I
K
S
M
F
S
G
E
K
I
N
R
T
E
N
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
L
-
V
D
G
K
D
V
M
P
E
V
N
A
V
L
E
K
M
K
T
F
S
E
A
I
I
S
G
E
W
K
G
Y
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
---
R
P
Y
K
-----
N
H
-
L
N
M
H
---
F
V
-
S
N
V
D
G
T
H
I
A
E
V
L
K
K
V
N
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
S
A
R
D
W
-
F
L
K
-
A
A
------
G
------
D
------
E
------
K
H-
V
A
K
H
F
T
A
L
S
T
N
A
K
A
V
G
E
F
G
I
D
T
A
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
V
L
S
I
-
G
F
D
N
F
V
E
L
L
S
G
A
H
A
M
D
K
H
F
S
T
T
P
A
E
K
N
L
P
V
L
L
A
L
I
G
I
W
Y
N
N
F
F
G
A
E
T
E
A
I
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
V
V
D
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
V
P
C
D
F
I
A
P
A
ITH
N
P
L
S
D
----------
H
H
Q
K
L
L
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
R
E
----
V
----
V
-----
E
Q
E
YRDQGKDP-
A
--------
T
L
--------
D
---------
Y
---------
V
V
P
F
K
V
F
E
G
N
R
P
T
N
S
I
L
L
R
E
I
T
P
F
S
L
G
A
L
I
A
L
Y
E
H
K
I
F
T
Q
G
V
I
L
N
I
F
T
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
R
I
L
P
E
L
K
D
---
D
K
-------
E
I
S
S
H
-
D
S
S
T
N
G
L
I
N
R
Y
K
A
W
R
G
---
61
PsiBlast_CBE
84.84
47%
-103
- C6 -
2O2C
4
G6PI_TRYBB
C:
[50-601]
-----------------------------------------------------
L
T
S
C
A
S
W
T
Q
L
Q
K
-
L
Y
E
Q
-
Y
G
D
E
-
P
I
K
K
H
F
E
T
D
S
E
R
G
Q
R
Y
S
V
K
V
SLGSKDE
N
-------
F
-
L
F
L
D
Y
S
K
S
H
I
N
D
E
I
K
C
A
L
L
R
L
A
E
E
R
G
I
R
Q
F
V
Q
S
V
F
R
G
E
R
V
N
T
T
E
N
R
P
V
L
H
I
A
L
R
N
R
S
N
R
P
I
-
Y
-
V
D
G
K
D
V
M
P
A
V
N
K
V
L
D
Q
M
R
S
F
S
E
K
V
R
T
G
E
W
K
G
H
T
G
K
A
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
E
A
L
---
K
P
F
S
-----
Q
R
D
L
S
L
H
---
F
V
-
S
N
V
D
G
T
H
I
A
E
V
L
K
S
I
D
I
E
A
T
L
F
I
V
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
R
A
-
L
L
D
-
Y
L
RSRGID
E
------
K
------
G
------
S
--
V
A
K
H
F
V
A
L
S
T
N
N
Q
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
M
W
S
A
I
G
-
L
-
P
I
M
I
S
I
-
G
Y
E
N
F
V
E
L
L
T
G
A
H
V
I
D
E
H
F
A
N
A
P
P
E
Q
N
V
P
L
L
L
A
L
V
G
V
W
Y
I
N
F
F
G
A
V
T
H
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
Y
V
T
R
S
G
K
T
V
S
T
L
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
N
L
I
P
C
D
F
I
G
A
I
---
Q
S
Q
N
K
I
-------
G
D
H
H
K
I
F
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
S
P
S
----
E
----
V
-----
R
R
E
---------
L
--------
E
A
--------
A
GERSAEKIN
A
---------
L
L
P
H
K
T
F
I
G
G
R
P
S
N
T
L
L
I
K
S
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
D
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
R
---
P
G
M
-------
R
V
N
N
H
-
D
S
S
T
N
G
L
I
N
M
F
--------
3
PsiBlast_PDB
84.83
51%
-99
- C6 -
3NBU
-
G6PI_ECOLI
A:
[7-549]
------------------------------------------------------
T
Q
T
A
A
W
Q
A
L
Q
K
-
H
F
D
E
-
M
K
D
V
-
T
I
A
D
L
F
A
K
D
G
D
R
F
S
K
F
S
A
T
F
-------
D
-------
D
Q
M
L
V
D
Y
S
K
N
R
I
T
E
E
T
L
A
K
L
Q
D
L
A
K
E
C
D
L
A
G
A
I
K
S
M
F
S
G
E
K
I
N
R
T
E
N
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
L
-
V
D
G
K
D
V
M
P
E
V
N
A
V
L
E
K
M
K
T
F
S
E
A
I
I
S
G
E
W
K
G
Y
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
---
R
P
Y
K
-----
N
H
-
L
N
M
H
---
F
V
-
S
N
V
D
G
T
H
I
A
E
V
L
K
K
V
N
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
S
A
R
D
W
-
F
L
K
-
A
A
------
G
------
D
------
E
------
K
H-
V
A
K
H
F
T
A
L
S
T
N
----
G
E
F
G
I
D
T
A
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
V
L
S
I
-
G
F
D
N
F
V
E
L
L
S
G
A
H
A
M
D
K
H
F
S
T
T
P
A
E
K
N
L
P
V
L
L
A
L
I
G
I
W
Y
N
N
F
F
G
A
E
T
E
A
I
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
V
V
D
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
V
P
C
D
F
I
A
P
A
ITH
N
P
L
S
D
----------
H
H
Q
K
L
L
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
R
E
----
V
----
V
-----
E
Q
E
Y
R
D
Q
GKDP-
A
--------
T
L
--------
D
---------
Y
---------
V
V
P
F
K
V
F
E
G
N
R
P
T
N
S
I
L
L
R
E
I
T
P
F
S
L
G
A
L
I
A
L
Y
E
H
K
I
F
T
Q
G
V
I
L
N
I
F
T
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
R
I
L
P
E
L
K
D
---
D
K
-------
E
I
S
S
H
-
D
S
S
T
N
G
L
I
N
R
Y
K
A
W
R
G
---
98
HHSearch
84.81
52%
-99
- C6 -
3HJB
12
G6PI_VIBCH
A:
[24-573]
----------------------------------------------
A
M
L
K
N
I
N
P
T
Q
T
Q
A
W
K
A
L
T
A
-
H
F
E
S
-
A
Q
D
M
-
D
L
K
A
L
F
A
Q
D
S
E
R
F
A
K
Y
S
A
R
F
G
------
Q
-------
D
-
I
L
V
D
Y
S
K
N
L
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
T
D
L
Q
S
A
I
T
A
M
F
K
G
E
A
I
N
Q
T
E
D
R
A
V
L
H
T
A
L
R
N
R
S
N
S
P
V
-
L
-
V
N
G
E
D
V
M
P
A
V
N
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
G
E
W
K
G
F
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
---
V
P
Y
K
------
N
H
L
T
V
H
---
F
V
-
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
D
W
-
F
L
K
-
A
A
------
G
------
D
------
E
A-----
H
--
V
A
K
H
F
A
A
L
S
T
N
G
K
A
V
A
E
F
G
I
D
T
D
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
I
L
S
I
--
G
Y
D
N
F
V
E
L
L
A
G
A
H
E
M
D
Q
H
F
V
N
T
P
F
E
S
N
I
P
V
I
L
A
L
I
G
I
W
Y
N
N
F
H
G
A
E
S
E
A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
P
V
T
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
A
P
A
---
V
S
H
N
L
V
-------
G
D
H
H
Q
K
L
M
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
A
Q
----
A
----
V
-----
Q
A
E
---------
L
E
K
A
GKS
A
A
E
I
--------
A
---------
A
---------
L
V
P
F
K
V
F
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
D
--
S
A
A
--------
V
T
S
H
-
D
S
S
T
N
G
L
I
N
A
F
K
A
F
R
----
28
PsiBlast_CBE
84.79
49%
-99
- C6 -
1KOJ
2
G6PI_RABIT
B:
[3-552]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
NTNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
-
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
RKELQ
A
A
G
---------
K
--------
S
P
--------
E
DLM------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
-
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
2
PsiBlast_PDB
84.79
51%
-101
- C6 -
3HJB
12
G6PI_VIBCH
A:
[32-573]
------------------------------------------------------
T
Q
T
Q
A
W
K
A
L
T
A
-
H
F
E
S
-
A
Q
D
M
-
D
L
K
A
L
F
A
Q
D
S
E
R
F
A
K
Y
S
A
R
F
-------
G
Q------
D
-
I
L
V
D
Y
S
K
N
L
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
T
D
L
Q
S
A
I
T
A
M
F
K
G
E
A
I
N
Q
T
E
D
R
A
V
L
H
T
A
L
R
N
R
S
N
S
P
V
-
L
-
V
N
G
E
D
V
M
P
A
V
N
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
G
E
W
K
G
F
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
---
V
P
Y
K
-----
N
H
-
L
T
V
H
---
F
V
-
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
D
W
-
F
L
K
-
A
A
------
G
------
D
------
E
------
A
H-
V
A
K
H
F
A
A
L
S
T
N
G
K
A
V
A
E
F
G
I
D
T
D
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
I
L
S
I
-
G
Y
D
N
F
V
E
L
L
A
G
A
H
E
M
D
Q
H
F
V
N
T
P
F
E
S
N
I
P
V
I
L
A
L
I
G
I
W
Y
N
N
F
H
G
A
E
S
E
A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
P
V
T
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
A
P
A
---------
V
S
H
N
-
L
V
G
D
H
H
Q
K
L
M
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
A
Q
----
A
----
V
-----
Q
A
E
L
E
K
A
GKS
A
-
A
--------
E
I
--------
A
---------
A
---------
L
V
P
F
K
V
F
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
D
--
S
A
A
-------
V
T
S
H
--
D
S
S
T
N
G
L
I
N
A
F
K
A
F
R
----
16
PsiBlast_PDB
84.72
48%
-101
- C6 -
2CXN
4
G6PI_MOUSE
A:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
NTNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
E
D
L
-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
62
PsiBlast_CBE
84.70
47%
-104
- C6 -
2O2C
5
G6PI_TRYBB
B:
[50-601]
-----------------------------------------------------
L
T
S
C
A
S
W
T
Q
L
Q
K
-
L
Y
E
Q
-
Y
G
D
E
-
P
I
K
K
H
F
E
T
D
S
E
R
G
Q
R
Y
S
V
K
V
S
LGSKDE
N
-------
F
-
L
F
L
D
Y
S
K
S
H
I
N
D
E
I
K
C
A
L
L
R
L
A
E
E
R
G
I
R
Q
F
V
Q
S
V
F
R
G
E
R
V
N
T
T
E
N
R
P
V
L
H
I
A
L
R
N
R
S
N
R
P
I
-
Y
-
V
D
G
K
D
V
M
P
A
V
N
K
V
L
D
Q
M
R
S
F
S
E
K
V
R
T
G
E
W
K
G
H
T
G
K
A
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
E
A
L
---
K
P
F
S
-----
Q
R
D
L
S
L
H
---
F
V
-
S
N
V
D
G
T
H
I
A
E
V
L
K
S
I
D
I
E
A
T
L
F
I
V
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
R
A
-
L
L
D
-
Y
L
R
S
R
GID
E
------
K
------
G
------
S
--
V
A
K
H
F
V
A
L
S
T
N
N
Q
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
M
W
S
A
I
G
-
L
-
P
I
M
I
S
I
-
G
Y
E
N
F
V
E
L
L
T
G
A
H
V
I
D
E
H
F
A
N
A
P
P
E
Q
N
V
P
L
L
L
A
L
V
G
V
W
Y
I
N
F
F
G
A
V
T
H
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
Y
V
T
R
S
G
K
T
V
S
T
L
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
N
L
I
P
C
D
F
I
G
A
I
---
Q
S
Q
N
K
I
-------
G
D
H
H
K
I
F
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
S
P
S
----
E
----
V
-----
R
R
E
---------
L
--------
E
A
--------
A
GERS
A
E
K
I
N
A
---------
L
L
P
H
K
T
F
I
G
G
R
P
S
N
T
L
L
I
K
S
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
D
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
R
---
P
G
M
-------
R
V
N
N
H
-
D
S
S
T
N
G
L
I
N
M
F
--------
38
PsiBlast_CBE
84.56
48%
-101
- C6 -
2CXS
5
G6PI_MOUSE
A:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
TNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
E
D
L
-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
5
PsiBlast_PDB
84.53
49%
-101
- C6 -
1HOX
2
G6PI_RABIT
A:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
TNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
-
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
--------
E
D
L
M
------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
-
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
86
Fugue
84.52
47%
-98
- C6 -
4QFH
2
?
A:
[6-615]
H
H
H
M
K
D
Q
Y
L
K
D
L
T
V
H
L
N
E
SNAAPAN
T
S
M
A
V
A
S
F
N
M
P
H
E
I
T
R
R
M
RP
L
G
V
D
A
D
T
S
L
T
S
C
P
S
W
R
R
L
Q
E
-
L
Y
E
I
-
H
G
S
E
-
S
I
L
K
N
F
D
E
C
K
D
R
F
Q
R
Y
S
L
E
V
-------
D
LRSSDK
N
F
-
V
F
L
D
Y
S
K
T
H
I
N
D
E
I
K
D
V
L
F
K
L
V
E
E
R
G
I
R
A
F
M
R
A
L
F
A
G
E
K
V
N
T
A
E
N
R
S
V
L
H
I
A
L
R
N
R
S
N
R
P
I
-
F
-
V
N
G
H
D
V
M
P
L
V
N
K
V
L
E
Q
M
K
K
L
S
E
K
V
R
R
G
E
W
K
G
Q
S
G
K
P
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
M
M
A
C
E
A
L
---
R
P
F
S
-----
D
R
R
I
S
M
H
---
F
V
-
S
N
I
D
G
T
H
L
S
E
V
L
N
L
V
D
L
E
S
T
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
N
E
-
F
L
K
-
F
L
------
S
------
S
------
R
GISEAG
A
--
V
A
K
H
F
V
A
L
S
T
N
A
E
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
V
M
I
S
I
-
G
Y
D
N
F
V
E
L
L
T
G
A
H
I
M
D
E
H
F
I
N
A
P
T
E
N
N
L
P
I
I
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
A
T
K
N
G
R
M
V
S
T
H
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
G
A
I
---
Q
------
T
Q
N
-
Y
I
G
E
H
H
R
I
L
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
T
P
E
----
E
----
V
-----
K
R
E
L
E
S
A
GGKS
E
D
--------
E
I
--------
Q
---------
L
---------
L
I
P
Q
K
T
F
T
G
G
R
P
S
N
S
L
L
V
K
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
L
L
A
K
S
I
L
L
Q
L
Q
---
P
G
Q
-------
K
V
T
N
H
-
D
S
S
T
N
G
L
I
E
L
F
N
E
R
S
H
---
42
PsiBlast_CBE
84.45
48%
-103
- C6 -
2CXO
5
G6PI_MOUSE
B:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
NTNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
RKELQ
A
A
G
---------
K
--------
S
P
EDL-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
37
PsiBlast_CBE
84.45
48%
-103
- C6 -
2CXS
5
G6PI_MOUSE
B:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
NTNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
RKELQ
A
A
G
---------
K
--------
S
P
EDL-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
36
PsiBlast_CBE
84.45
48%
-101
- C6 -
2CXT
5
G6PI_MOUSE
A:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
TNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
E
D
L
-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
8
PsiBlast_PDB
84.45
49%
-100
- C6 -
1DQR
2
G6PI_RABIT
A:
[3-552]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
TNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
-
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
--------
E
D
L
M
------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
-
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
51
PsiBlast_CBE
84.41
48%
-103
- C6 -
1T10
1
G6PI_LEIME
A:
[54-601]
---------------------------------------------------------
P
A
W
K
R
L
Q
S
-
L
Y
E
K
-
Y
G
N
D
-
S
I
L
S
H
F
E
K
D
H
Q
R
F
Q
R
Y
S
I
E
I
D
LHSDD-
N
-------
F
-
L
F
L
D
Y
S
K
S
H
I
N
D
E
I
K
D
A
L
V
A
L
A
E
E
R
G
V
R
A
F
A
K
A
M
F
D
G
Q
R
V
N
S
T
E
N
R
A
V
L
H
V
A
L
R
N
R
S
N
R
P
I
-
I
-
V
D
G
K
D
V
M
S
D
V
N
N
V
L
A
Q
M
K
D
F
T
E
R
V
R
S
G
E
W
K
G
Q
T
G
K
S
I
Y
N
I
V
N
I
G
I
G
G
S
D
L
G
P
V
M
V
T
E
A
L
---
K
P
F
S
-----
K
R
D
L
H
C
F
---
F
V
-
S
N
V
D
G
T
H
M
A
E
V
L
K
Q
V
N
L
E
E
T
I
F
I
I
A
S
K
T
F
T
T
Q
E
T
L
T
N
A
M
S
A
R
N
A
-
L
M
S
-
Y
L
------
K
E
N
GIST
D
------
G
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
E
K
V
R
E
F
G
I
D
T
V
N
M
F
A
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
I
G
-
L
-
S
V
M
L
S
I
-
G
Y
D
N
F
V
E
F
L
T
G
A
H
V
M
D
N
H
F
A
S
T
P
T
E
Q
N
L
P
M
M
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
V
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
V
T
K
K
S
G
A
V
A
V
Q
T
G
P
I
V
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
I
I
P
C
D
F
I
G
C
V
---
Q
------
T
Q
N
-
R
V
G
D
H
H
R
T
L
M
S
N
F
F
A
Q
T
E
A
L
M
V
G
K
N
A
E
----
E
----
V
-----
R
Q
E
---------
L
--------
V
K
--------
S
GMSGD
A
I
E
-
N
---------
M
I
P
H
K
T
F
T
G
S
R
P
S
N
S
I
L
V
N
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
K
---
S
G
N
-------
I
V
S
D
H
-
D
G
S
T
N
G
L
I
N
M
F
N
T
------
35
PsiBlast_CBE
84.41
48%
-102
- C6 -
2CXT
5
G6PI_MOUSE
B:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
NTNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
RKELQ
A
A
G
---------
K
--------
S
P
EDL-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
45
PsiBlast_CBE
84.40
48%
-102
- C6 -
1U0G
11
G6PI_MOUSE
B:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
NTNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
RKELQ
A
A
G
---------
K
--------
S
P
EDL-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
40
PsiBlast_CBE
84.37
48%
-103
- C6 -
2CXQ
5
G6PI_MOUSE
B:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
NTNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
RKELQ
A
A
G
---------
K
--------
S
P
EDL-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
29
PsiBlast_CBE
84.31
49%
-99
- C6 -
1DQR
2
G6PI_RABIT
B:
[3-552]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
NTNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
-
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
RKELQ
A
A
G
---------
K
--------
S
P
--------
E
DLM------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
-
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
85
Fugue
84.27
49%
-98
- C6 -
1DQR
2
G6PI_RABIT
A:
[1-555]
---------------------------------------------------
A
A
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
H
G
S
E
L
-
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
TNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
-
F
L
L
S
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
----
Q
H
P
I
-
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
-----
R
K
E
---------
L
--------
Q
A
A
GKS
P
E
D
L
M
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
---
S
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
-
9
PsiBlast_PDB
84.26
49%
-100
- C6 -
1KOJ
2
G6PI_RABIT
A:
[3-552]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
TNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
-
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
--------
E
D
L
M
------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
-
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
48
PsiBlast_CBE
84.22
48%
-101
- C6 -
1U0F
16
G6PI_MOUSE
A:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
TNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
E
D
L
-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
4
PsiBlast_PDB
84.16
49%
-99
- C6 -
1G98
2
G6PI_RABIT
A:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
TNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
-
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
--------
E
D
L
M
------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
-
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
41
PsiBlast_CBE
84.15
48%
-102
- C6 -
2CXP
5
G6PI_MOUSE
B:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
NTNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
RKELQ
A
A
G
---------
K
--------
S
P
EDL-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
46
PsiBlast_CBE
84.13
48%
-101
- C6 -
1U0G
14
G6PI_MOUSE
A:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
N
TNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
E
D
L
-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
39
PsiBlast_CBE
84.10
48%
-101
- C6 -
2CXR
5
G6PI_MOUSE
B:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
NTNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
RKELQ
A
A
G
---------
K
--------
S
P
EDL-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
27
PsiBlast_CBE
84.10
49%
-99
- C6 -
1G98
2
G6PI_RABIT
B:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
NTNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
-
A
K
------
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
RKELQ
A
A
G
---------
K
--------
S
P
--------
E
DLM------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
-
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
97
HHSearch
84.03
49%
-100
- C6 -
1T10
1
G6PI_LEIME
A:
[49-602]
----------------------------------------------------
S
L
L
N
L
P
A
W
K
R
L
Q
S
-
L
Y
E
K
-
Y
G
N
D
-
S
I
L
S
H
F
E
K
D
H
Q
R
F
Q
R
Y
S
I
E
I
D
LHSDD-
N
-------
F
-
L
F
L
D
Y
S
K
S
H
I
N
D
E
I
K
D
A
L
V
A
L
A
E
E
R
G
V
R
A
F
A
K
A
M
F
D
G
Q
R
V
N
S
T
E
N
R
A
V
L
H
V
A
L
R
N
R
S
N
R
P
I
-
I
-
V
D
G
K
D
V
M
S
D
V
N
N
V
L
A
Q
M
K
D
F
T
E
R
V
R
S
G
E
W
K
G
Q
T
G
K
S
I
Y
N
I
V
N
I
G
I
G
G
S
D
L
G
P
V
M
V
T
E
A
L
---
K
P
F
S
-----
K
R
D
L
H
C
F
---
F
V
-
S
N
V
D
G
T
H
M
A
E
V
L
K
Q
V
N
L
E
E
T
I
F
I
I
A
S
K
T
F
T
T
Q
E
T
L
T
N
A
M
S
A
R
N
A
-
L
M
S
-
Y
L
------
K
------
E
N
GISTD
G
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
E
K
V
R
E
F
G
I
D
T
V
N
M
F
A
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
I
G
-
L
S
V
M
L
S
I
--
G
Y
D
N
F
V
E
F
L
T
G
A
H
V
M
D
N
H
F
A
S
T
P
T
E
Q
N
L
P
M
M
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
V
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
V
T
K
K
S
G
A
V
A
V
Q
T
G
P
I
V
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
I
I
P
C
D
F
I
G
C
V
---
Q
T
Q
N
R
V
-------
G
D
H
H
R
T
L
M
S
N
F
F
A
Q
T
E
A
L
M
V
G
K
N
A
E
----
E
----
V
-----
R
Q
E
---------
L
--------
V
K
S
GMSGD
A
I
E
---------
N
---------
M
I
P
H
K
T
F
T
G
S
R
P
S
N
S
I
L
V
N
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
K
S
--
G
N
I
--------
V
S
D
H
-
D
G
S
T
N
G
L
I
N
M
F
N
T
R
-----
65
PsiBlast_CBE
83.97
45%
-100
- C6 -
4QFH
2
?
A:
[59-610]
-----------------------------------------------------
L
T
S
C
P
S
W
R
R
L
Q
E
-
L
Y
E
I
-
H
G
S
E
-
S
I
L
K
N
F
D
E
C
K
D
R
F
Q
R
Y
S
L
E
V
D
LRSSDK
N
-------
F
-
V
F
L
D
Y
S
K
T
H
I
N
D
E
I
K
D
V
L
F
K
L
V
E
E
R
G
I
R
A
F
M
R
A
L
F
A
G
E
K
V
N
T
A
E
N
R
S
V
L
H
I
A
L
R
N
R
S
N
R
P
I
-
F
-
V
N
G
H
D
V
M
P
L
V
N
K
V
L
E
Q
M
K
K
L
S
E
K
V
R
R
G
E
W
K
G
Q
S
G
K
P
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
M
M
A
C
E
A
L
---
R
P
F
S
-----
D
R
R
I
S
M
H
---
F
V
-
S
N
I
D
G
T
H
L
S
E
V
L
N
L
V
D
L
E
S
T
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
N
E
-
F
L
K
-
F
L
------
S
------
S
R
GISEA
G
------
A
--
V
A
K
H
F
V
A
L
S
T
N
A
E
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
V
M
I
S
I
-
G
Y
D
N
F
V
E
L
L
T
G
A
H
I
M
D
E
H
F
I
N
A
P
T
E
N
N
L
P
I
I
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
A
T
K
N
G
R
M
V
S
T
H
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
G
A
I
---
Q
------
T
Q
N
-
Y
I
G
E
H
H
R
I
L
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
T
P
E
----
E
----
V
-----
K
R
E
---------
L
--------
E
S
--------
A
---------
G
GKS
E
D
E
I
Q
L
L
I
P
Q
K
T
F
T
G
G
R
P
S
N
S
L
L
V
K
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
L
L
A
K
S
I
L
L
Q
L
Q
---
P
G
Q
-------
K
V
T
N
H
-
D
S
S
T
N
G
L
I
E
L
F
--------
87
Fugue
83.94
49%
-100
- C6 -
1DQR
2
G6PI_RABIT
A:
[1-555]
---------------------------------------------------
A
A
L
T
R
N
P
Q
F
Q
K
L
Q
Q
-
W
H
R
E
H
G
S
E
L
-
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
N
TNH---
G
-------
H
-
I
L
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
KPY
S
S
--------
G
G
P
R
V
W
---
F
V
S
-
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
-
F
L
L
-
S
A
K-----
D
------
P
------
S
------
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
---
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
-----I
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
----
E
----
A
-----
R
K
E
---------
L
--------
Q
A
A
GKS
P
E
D
L
M
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
---
S
S
-------
P
V
T
S
H
-
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
-
18
PsiBlast_PDB
83.81
48%
-102
- C6 -
2CXP
5
G6PI_MOUSE
A:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
NTNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
E
D
L
-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
20
PsiBlast_PDB
83.75
48%
-100
- C6 -
2CXR
5
G6PI_MOUSE
A:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
NTNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
E
D
L
-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
17
PsiBlast_PDB
83.64
48%
-99
- C6 -
2CXO
5
G6PI_MOUSE
A:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
NTNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
E
D
L
-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
64
PsiBlast_CBE
83.51
45%
-100
- C6 -
4QFH
2
?
B:
[59-610]
-----------------------------------------------------
L
T
S
C
P
S
W
R
R
L
Q
E
-
L
Y
E
I
-
H
G
S
E
-
S
I
L
K
N
F
D
E
C
K
D
R
F
Q
R
Y
S
L
E
V
D
LRSSDK
N
-------
F
-
V
F
L
D
Y
S
K
T
H
I
N
D
E
I
K
D
V
L
F
K
L
V
E
E
R
G
I
R
A
F
M
R
A
L
F
A
G
E
K
V
N
T
A
E
N
R
S
V
L
H
I
A
L
R
N
R
S
N
R
P
I
-
F
-
V
N
G
H
D
V
M
P
L
V
N
K
V
L
E
Q
M
K
K
L
S
E
K
V
R
R
G
E
W
K
G
Q
S
G
K
P
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
M
M
A
C
E
A
L
---
R
P
F
S
-----
D
R
R
I
S
M
H
---
F
V
-
S
N
I
D
G
T
H
L
S
E
V
L
N
L
V
D
L
E
S
T
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
N
E
-
F
L
K
-
F
L
------
S
------
S
R
GISEA
G
------
A
--
V
A
K
H
F
V
A
L
S
T
N
A
E
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
V
M
I
S
I
-
G
Y
D
N
F
V
E
L
L
T
G
A
H
I
M
D
E
H
F
I
N
A
P
T
E
N
N
L
P
I
I
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
A
T
K
N
G
R
M
V
S
T
H
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
G
A
I
---
Q
------
T
Q
N
-
Y
I
G
E
H
H
R
I
L
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
T
P
E
----
E
----
V
-----
K
R
E
---------
L
--------
E
S
--------
A
---------
G
GKS
E
D
E
I
Q
L
L
I
P
Q
K
T
F
T
G
G
R
P
S
N
S
L
L
V
K
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
L
L
A
K
S
I
L
L
Q
L
Q
---
P
G
Q
-------
K
V
T
N
H
-
D
S
S
T
N
G
L
I
E
L
F
--------
19
PsiBlast_PDB
83.48
48%
-100
- C6 -
2CXQ
5
G6PI_MOUSE
A:
[4-553]
-----------------------------------------------------
L
T
R
N
P
Q
F
Q
K
L
L
E
W
H
R
A
N
-
S
A
N
L
-
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
NTNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
V
W
---
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
E
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
-----
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
E
D
L
-----
E
---------
K
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
--
S
-
S
-------
A
V
T
S
H
-
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
----
52
PsiBlast_CBE
83.40
47%
-102
- C6 -
1IAT
3
G6PI_HUMAN
A:
[3-552]
-----------------------------------------------------
L
T
R
D
P
Q
F
Q
K
L
Q
Q
W
Y
R
E
H
-
R
S
E
L
-
N
L
R
R
L
F
D
A
N
K
D
R
F
N
H
F
S
L
T
L
N
TNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
T
E
D
V
M
R
M
L
V
D
L
A
K
S
R
G
V
E
A
A
R
E
R
M
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
L
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
Y
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
Q
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
T
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
F
G
C
E
T
H
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
R
G
K
S
T
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
E
D
L
-----
E
---------
R
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
M
L
G
A
L
V
A
M
Y
E
H
K
I
F
V
Q
G
I
I
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
A
Q
-------
V
T
S
H
--
D
A
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
53
PsiBlast_CBE
83.10
47%
-101
- C6 -
1NUH
7
G6PI_HUMAN
A:
[4-553]
-----------------------------------------------------
L
T
R
D
P
Q
F
Q
K
L
Q
Q
W
Y
R
E
H
-
R
S
E
L
-
N
L
R
R
L
F
D
A
N
K
D
R
F
N
H
F
S
L
T
L
N
TNH---
G
-------
H
-
I
L
V
D
Y
S
K
N
L
V
T
E
D
V
M
R
M
L
V
D
L
A
K
S
R
G
V
E
A
A
R
E
R
M
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
I
-
L
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
V
W
---
Y
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
-
F
L
Q
-
A
A
------
K
------
D
P-----
S
------
A
--
V
A
K
H
F
V
A
L
S
T
N
T
T
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
-
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
F
G
C
E
T
H
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
---
Q
T
Q
H
P
I
R
-----
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
R
G
K
S
T
E
----
E
----
A
R
K
E
L
Q
A
A
G
---------
K
--------
S
P
E
D
L
-----
E
---------
R
---------
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
M
L
G
A
L
V
A
M
Y
E
H
K
I
F
V
Q
G
I
I
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
--
S
A
Q
-------
V
T
S
H
--
D
A
S
T
N
G
L
I
N
F
I
K
Q
Q
R
----
99
HHSearch
80.79
45%
-94
- C6 -
3UJH
3
?
A:
[5-566]
------------------------------------------------
M
A
P
T
Q
L
E
Q
C
A
S
H
G
K
L
L
Q
-
E
K
K
K
-
L
E
K
L
-
H
L
R
D
L
L
K
-
D
E
A
R
N
D
L
L
I
R
S
T
D------
Q
-------
G
-
V
Y
L
D
F
S
R
Q
K
I
T
L
E
T
L
Q
H
L
V
N
L
A
H
E
R
Q
V
P
A
M
V
K
R
M
F
S
G
E
K
I
N
Q
T
E
N
R
A
V
L
H
V
A
L
R
M
P
E
G
S
E
P
V
H
-
V
D
G
K
N
V
L
D
E
V
H
A
V
L
R
R
I
R
V
F
S
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K
V
R
S
G
E
I
R
G
H
T
G
K
K
L
V
N
V
I
S
I
G
I
G
G
S
Y
L
G
T
E
F
V
H
L
A
L
---
A
A
E
G
Y
A
A
E
K
A
H
G
R
Q
I
H
---
F
L
-
A
N
V
D
P
V
D
V
W
L
A
E
R
G
F
D
P
E
E
T
L
V
V
V
I
S
K
T
F
T
T
A
E
T
M
M
N
A
R
S
V
R
D
W
-
Y
L
H
-
H
Y
------
K
------
G
------
D
------
E
RA
L
G
A
H
F
C
A
V
S
T
N
L
D
G
T
S
K
F
G
I
Q
S
D
R
V
F
G
F
W
D
W
V
G
G
R
Y
S
V
T
S
A
V
G
-
I
L
P
L
A
L
Q
Y
-
G
Y
D
V
A
Q
E
F
L
N
G
A
H
A
M
D
V
H
F
K
T
A
E
L
A
D
N
L
P
M
L
M
G
L
I
S
V
W
N
A
T
F
F
G
Y
S
N
V
A
V
L
P
Y
A
Q
A
L
L
R
F
P
A
H
I
Q
Q
L
T
M
E
S
N
G
K
R
V
T
M
D
G
K
T
L
D
F
D
V
G
E
I
F
F
G
E
P
G
T
N
G
Q
H
S
F
Y
Q
L
I
H
Q
G
R
-
V
I
P
A
E
F
I
G
F
C
---
K
S
Q
R
A
I
K
L
K
E
-
E
P
V
S
N
H
D
E
L
M
S
N
F
F
A
Q
P
D
A
L
A
F
G
K
T
P
E
----
E
----
L
-----
R
K
E
---------
G
--------
I
P
--------
E
---------
K
---------
L
V
P
H
K
T
F
P
G
D
R
P
S
C
M
L
L
F
P
E
I
S
P
F
H
I
G
Q
L
L
A
L
Y
E
H
R
V
A
V
E
G
W
L
W
G
I
N
S
F
D
Q
W
G
V
E
L
G
K
V
L
A
K
G
V
R
G
I
L
Q
K
--
R
R
E
GKAPHES
G
Q
S
E
L
-
C
S
S
T
R
K
I
L
E
H
Y
V
Q
Q
S
K
---
68
PsiBlast_CBE
79.67
43%
-97
- C6 -
3Q88
6
G6PI_FRATT
A:
[18-542]
-------------------------------------------------------------------------
N
I
-
N
L
K
N
E
F
D
K
D
D
K
R
V
E
K
F
S
L
K
H
-------
Q
-------
N
-
I
Y
F
D
Y
S
K
N
L
I
N
D
Y
I
L
K
S
L
L
E
S
A
E
K
S
S
L
K
D
K
I
K
Q
M
F
N
G
A
K
I
N
S
T
E
H
R
A
V
L
H
T
A
L
R
D
L
S
S
T
P
L
-
I
-
V
D
G
Q
D
I
R
Q
E
V
T
K
E
K
Q
R
V
K
E
L
V
E
K
V
V
S
G
R
W
R
G
F
S
G
K
K
I
T
D
I
V
N
I
G
I
G
G
S
D
L
G
P
K
M
V
V
R
A
L
---
Q
P
Y
H
-----
C
T
D
L
K
V
H
---
F
V
-
S
N
V
D
A
D
S
L
L
Q
A
L
H
V
V
D
P
E
T
T
L
L
I
I
A
S
K
S
F
S
T
E
E
T
L
L
N
S
I
S
A
R
E
W
-
L
L
D
-
H
Y
------
E
------
D
E-----
K
------
A
--
V
A
N
H
F
V
A
I
S
S
K
L
D
K
V
K
E
F
G
I
D
L
E
H
C
Y
K
M
W
D
W
V
G
G
R
Y
S
L
W
S
S
I
G
-
M
-
S
I
A
F
A
I
-
G
Y
D
N
F
E
K
L
L
A
G
A
Y
S
V
D
K
H
F
K
E
T
E
F
S
K
N
I
P
V
I
M
A
L
L
A
S
Y
Y
S
C
T
Y
N
S
Q
S
Q
A
L
L
P
Y
D
E
R
L
C
Y
F
V
D
Y
L
Q
Q
A
D
M
E
S
N
G
K
S
V
N
I
A
G
E
T
V
N
Y
Q
T
G
V
V
L
W
G
G
V
G
T
N
G
Q
H
A
F
H
Q
L
L
H
Q
G
N
I
F
I
P
V
D
F
I
A
I
A
---------
T
S
H
H
-
N
Y
D
N
H
Q
Q
A
L
L
A
N
C
F
A
Q
S
Q
A
L
M
F
G
Q
S
Y
D
M
V
Y
N
E
----
L
-----
L
K
S
---------
G
LN
E
T
----
Q
A
--------
K
---------
E
---------
L
A
A
H
K
V
I
P
G
N
R
P
S
T
T
I
L
L
D
E
L
S
P
Y
S
L
G
A
L
I
A
L
Y
E
H
K
I
F
V
Q
G
V
L
W
D
I
N
S
Y
D
Q
W
G
V
E
L
G
K
K
L
G
K
N
I
L
K
A
M
N
D
--
D
S
S
-------
D
E
Y
Q
N
L
D
D
S
T
R
Q
L
I
A
K
V
K
N
------
66
PsiBlast_CBE
79.57
47%
-92
- C6 -
3UJH
4
?
B:
[19-548]
--------------------------------------------------------------
L
L
Q
-
E
K
K
K
-
L
E
K
L
-
H
L
R
D
L
L
K
D
E
A
R
N
D
L
L
I
R
S
T
D
-------
Q
-------
G
-
V
Y
L
D
F
S
R
Q
K
I
T
L
E
T
L
Q
H
L
V
N
L
A
H
E
R
Q
V
P
A
M
V
K
R
M
F
S
G
E
K
I
N
Q
T
E
N
R
A
V
L
H
V
A
L
R
M
P
E
G
S
E
P
-
V
H
V
D
G
K
N
V
L
D
E
V
H
A
V
L
R
R
I
R
V
F
S
E
K
V
R
S
G
E
I
R
G
H
T
G
K
K
L
V
N
V
I
S
I
G
I
G
G
S
Y
L
G
T
E
F
V
H
L
A
L
A
A-
E
G
Y
A
-----
A
E
K
A
H
G
R
Q
I
H
F
L
-
A
N
V
D
P
V
D
V
W
L
A
E
R
G
F
D
P
E
E
T
L
V
V
V
I
S
K
T
F
T
T
A
E
T
M
M
N
A
R
S
V
R
D
W
Y
L
H
H
-
Y
K
------
G
------
D
------
E
R-----
A
--
L
G
A
H
F
C
A
V
S
T
N
L
D
G
T
S
K
F
G
I
Q
S
D
R
V
F
G
F
W
D
W
V
G
G
R
Y
S
V
T
S
A
V
G
I
L
-
P
L
A
L
Q
Y
-
G
Y
D
V
A
Q
E
F
L
N
G
A
H
A
M
D
V
H
F
K
T
A
E
L
A
D
N
L
P
M
L
M
G
L
I
S
V
W
N
A
T
F
F
G
Y
S
N
V
A
V
L
P
Y
A
Q
A
L
L
R
F
P
A
H
I
Q
Q
L
T
M
E
S
N
G
K
R
V
T
M
D
G
K
T
L
D
F
D
V
G
E
I
F
F
G
E
P
G
T
N
G
Q
H
S
F
Y
Q
L
I
H
Q
G
-
R
V
I
P
A
E
F
I
G
F
C
---
K
S
Q
R
A
I
K
L
K
E
-
E
P
V
S
N
H
D
E
L
M
S
N
F
F
A
Q
P
D
A
L
A
F
G
K
T
P
E
----
E
----
L
-----
R
K
E
---------
G
--------
I
P
--------
E
---------
K
---------
L
V
P
H
K
T
F
P
G
D
R
P
S
C
M
L
L
F
P
E
I
S
P
F
H
I
G
Q
L
L
A
L
Y
E
H
R
V
A
V
E
G
W
L
W
G
I
N
S
F
D
Q
W
G
V
E
L
G
K
V
L
A
K
G
V
R
G
I
L
Q
K
R
R
E
G
K
-------
A
P
H
E
S
-
G
Q
S
----------------
69
PsiBlast_CBE
79.31
43%
-96
- C6 -
3Q7I
6
G6PI_FRATT
A:
[18-542]
-------------------------------------------------------------------------
N
I
-
N
L
K
N
E
F
D
K
D
D
K
R
V
E
K
F
S
L
K
H
-------
Q
-------
N
-
I
Y
F
D
Y
S
K
N
L
I
N
D
Y
I
L
K
S
L
L
E
S
A
E
K
S
S
L
K
D
K
I
K
Q
M
F
N
G
A
K
I
N
S
T
E
H
R
A
V
L
H
T
A
L
R
D
L
S
S
T
P
L
-
I
-
V
D
G
Q
D
I
R
Q
E
V
T
K
E
K
Q
R
V
K
E
L
V
E
K
V
V
S
G
R
W
R
G
F
S
G
K
K
I
T
D
I
V
N
I
G
I
G
G
S
D
L
G
P
K
M
V
V
R
A
L
---
Q
P
Y
H
-----
C
T
D
L
K
V
H
---
F
V
-
S
N
V
D
A
D
S
L
L
Q
A
L
H
V
V
D
P
E
T
T
L
L
I
I
A
S
K
S
F
S
T
E
E
T
L
L
N
S
I
S
A
R
E
W
-
L
L
D
-
H
Y
------
E
------
D
E-----
K
------
A
--
V
A
N
H
F
V
A
I
S
S
K
L
D
K
V
K
E
F
G
I
D
L
E
H
C
Y
K
M
W
D
W
V
G
G
R
Y
S
L
W
S
S
I
G
-
M
-
S
I
A
F
A
I
-
G
Y
D
N
F
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L
L
A
G
A
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D
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H
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I
P
V
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L
L
A
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Y
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C
T
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Q
S
Q
A
L
L
P
Y
D
E
R
L
C
Y
F
V
D
Y
L
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Q
A
D
M
E
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N
G
K
S
V
N
I
A
G
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T
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Y
Q
T
G
V
V
L
W
G
G
V
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T
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H
A
F
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Q
L
L
H
Q
G
N
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F
I
P
V
D
F
I
A
I
A
---------
T
S
H
H
-
N
Y
D
N
H
Q
Q
A
L
L
A
N
C
F
A
Q
S
Q
A
L
M
F
G
Q
S
Y
D
M
V
Y
N
E
----
L
-----
L
K
S
---------
G
LN
E
T
----
Q
A
--------
K
---------
E
---------
L
A
A
H
K
V
I
P
G
N
R
P
S
T
T
I
L
L
D
E
L
S
P
Y
S
L
G
A
L
I
A
L
Y
E
H
K
I
F
V
Q
G
V
L
W
D
I
N
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Y
D
Q
W
G
V
E
L
G
K
K
L
G
K
N
I
L
K
A
M
N
D
--
D
S
S
-------
D
E
Y
Q
N
L
D
D
S
T
R
Q
L
I
A
K
V
K
N
------
67
PsiBlast_CBE
78.78
47%
-90
- C6 -
3UJH
3
?
A:
[19-548]
--------------------------------------------------------------
L
L
Q
-
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K
K
K
-
L
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L
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H
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-------
Q
-------
G
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A
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E
G
Y
A
-----
A
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A
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A
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-
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------
G
------
D
------
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R-----
A
--
L
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---
K
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----
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----
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---------
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--------
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---------
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---------
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-------
A
P
H
E
S
-
G
Q
S
----------------