@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0956: (2016-04-27 )
MQEPLRVPPSAPARLVVLASGTGSLLRSLLDAAVGDYPARVVAVGVDRECRAAEIAAEASVPVFTVRLADHPSRDAWDVAITAATAAHEPDLVVSAGFMRILGPQFLSRFYGRTLNTHPALLPAFPGTHGVADALAYGVKVTGATVHLVDAGTDTGPILAQQPVPVLDGDDEETLHERIKVTERRLLVAAVAALATHGVTVVGRTATMGRKVTIG
Atome Classification :
(55 SA)
.........10........20........30.-.-..-....40..--.....-.-50..--......60........70........80.........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200-.......210...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQEPLRVPPSA
P
A
R
L
V
V
L
ASG
T
G
S
L
L
R
S
L
L
D
A
-
A
-VG-DYP
A
R
V
V
A
--
V
GVDR-E-C
R
A
A
--
E
IAAEASV
P
V
F
T
V
R
LADHPSRD
A
W
D
V
A
-
I
T
A
ATAAHEP
D
L
V
V
S
A
G
F
M
R
IL
G
P
Q
F
L
S
R
F
YGRTLNTHPALLPAFPGT
H
G
V
A
D
A
L
A
Y
G
V
K
VT
G
A
T
V
H
L
V
DAGTDTGPILAQQPVPVLDGD
D
E
E
T
L
H
E
R
I
K
V
T
E
R
R
L
L
V
A
A
V
A
A
L
A
TH
G
V
T
V
V
-
G
RTATMG
R
K
VTIG
1
PsiBlast_PDB
98.97
99%
-143
- C3 -
3DA8
7
PUR3_MYCTU
A:
[3-215]
--
E
P
L
R
V
P
P
S
A
P
A
R
L
V
V
L
A
S
G
T
G
S
L
L
R
S
L
L
D
A
-
A
-
V
G
-
D
Y
P
A
R
V
V
A
--
V
G
V
D
R
-
E
-
C
R
A
A
--
E
I
A
A
E
A
S
V
P
V
F
T
V
R
L
A
D
H
P
S
R
D
A
W
D
V
A
-
I
T
A
A
T
A
A
H
E
P
D
L
V
V
S
A
G
F
M
R
I
L
G
P
Q
F
L
S
R
F
Y
G
R
T
L
N
T
H
P
A
L
L
P
A
F
P
G
T
H
G
V
A
D
A
L
A
Y
G
V
K
V
T
G
A
T
V
H
L
V
D
A
G
T
D
T
G
P
I
L
A
Q
Q
P
V
P
V
L
D
G
D
D
E
E
T
L
H
E
R
I
K
V
T
E
R
R
L
L
V
A
A
V
A
A
L
A
T
H
G
V
T
V
V
-
G
R
T
A
T
M
G
R
K
V
T
I
G
96
HHSearch
98.45
100%
-144
- C3 -
3DA8
6
PUR3_MYCTU
A:
[3-214]
--
E
P
L
R
V
P
P
S
A
P
A
R
L
V
V
L
A
S
G
T
G
S
L
L
R
S
L
L
D
A
-
A
-
V
G
-
D
Y
P
A
R
V
V
A
--
V
G
V
D
R
-
E
-
C
R
A
A
--
E
I
A
A
E
A
S
V
P
V
F
T
V
R
L
A
D
H
P
S
R
D
A
W
D
V
A
-
I
T
A
A
T
A
A
H
E
P
D
L
V
V
S
A
G
F
M
R
I
L
G
P
Q
F
L
S
R
F
Y
G
R
T
L
N
T
H
P
A
L
L
P
A
F
P
G
T
H
G
V
A
D
A
L
A
Y
G
V
K
V
T
G
A
T
V
H
L
V
D
A
G
T
D
T
G
P
I
L
A
Q
Q
P
V
P
V
L
D
G
D
D
E
E
T
L
H
E
R
I
K
V
T
E
R
R
L
L
V
A
A
V
A
A
L
A
T
H
G
V
T
V
V
-
G
R
T
A
T
M
G
R
K
V
T
I
-
22
PsiBlast_CBE
97.27
99%
-145
- C3 -
3DA8
4
PUR3_MYCTU
B:
[4-210]
---
P
L
R
V
P
P
S
A
P
A
R
L
V
V
L
A
S
G
T
G
S
L
L
R
S
L
L
D
A
-
A
-
V
G
-
D
Y
P
A
R
V
V
A
--
V
G
V
D
R
-
E
-
C
R
A
A
--
E
I
A
A
E
A
S
V
P
V
F
T
V
R
L
A
D
H
P
S
R
D
A
W
D
V
A
-
I
T
A
A
T
A
A
H
E
P
D
L
V
V
S
A
G
F
M
R
I
L
G
P
Q
F
L
S
R
F
Y
G
R
T
L
N
T
H
P
A
L
L
P
A
F
P
G
T
H
G
V
A
D
A
L
A
Y
G
V
K
V
T
G
A
T
V
H
L
V
D
A
--
D
T
G
P
I
L
A
Q
Q
P
V
P
V
L
D
G
D
D
E
E
T
L
H
E
R
I
K
V
T
E
R
R
L
L
V
A
A
V
A
A
L
A
T
H
G
V
T
V
V
-
G
R
T
A
T
M
G
R
-----
2
PsiBlast_PDB
96.81
99%
-143
- C3 -
3DCJ
4
PUR3_MYCTU
A:
[3-208]
--
E
P
L
R
V
P
P
S
A
P
A
R
L
V
V
L
A
S
G
T
G
S
L
L
R
S
L
L
D
A
-
A
-
V
G
-
D
Y
P
A
R
V
V
A
--
V
G
V
D
R
-
E
-
C
R
A
A
--
E
I
A
A
E
A
S
V
P
V
F
T
V
R
L
A
D
H
P
S
R
D
A
W
D
V
A
-
I
T
A
A
T
A
A
H
E
P
D
L
V
V
S
A
G
F
M
R
I
L
G
P
Q
F
L
S
R
F
Y
G
R
T
L
N
T
H
P
A
L
L
P
A
F
P
G
T
H
G
V
A
D
A
L
A
Y
G
V
K
V
T
G
A
T
V
H
L
V
D
A
G
T
D
T
G
P
I
L
A
Q
Q
P
V
P
V
L
D
G
D
D
E
E
T
L
H
E
R
I
K
V
T
E
R
R
L
L
V
A
A
V
A
A
L
A
T
H
G
V
T
V
V
-
G
R
T
A
T
M
-------
21
PsiBlast_CBE
96.43
99%
-145
- C3 -
3DCJ
4
PUR3_MYCTU
B:
[4-208]
---
P
L
R
V
P
P
S
A
P
A
R
L
V
V
L
A
S
G
T
G
S
L
L
R
S
L
L
D
A
-
A
-
V
G
-
D
Y
P
A
R
V
V
A
--
V
G
V
D
R
-
E
-
C
R
A
A
--
E
I
A
A
E
A
S
V
P
V
F
T
V
R
L
A
D
H
P
S
R
D
A
W
D
V
A
-
I
T
A
A
T
A
A
H
E
P
D
L
V
V
S
A
G
F
M
R
I
L
G
P
Q
F
L
S
R
F
Y
G
R
T
L
N
T
H
P
A
L
L
P
A
F
P
G
T
H
G
V
A
D
A
L
A
Y
G
V
K
V
T
G
A
T
V
H
L
V
D
A
G
T
D
T
G
P
I
L
A
Q
Q
P
V
P
V
L
D
G
D
D
E
E
T
L
H
E
R
I
K
V
T
E
R
R
L
L
V
A
A
V
A
A
L
A
T
H
G
V
T
V
V
-
G
R
T
A
T
M
-------
5
PsiBlast_PDB
73.85
42%
-126
- C3 -
3AUF
-
?
A:
[3-199]
-------------
R
I
G
V
L
I
S
G
S
G
T
N
L
Q
A
I
L
D
G
-
C
R
E
G
-
R
I
P
G
R
V
A
V
--
V
I
S
D
R
A
D
-
A
Y
G
L
--
E
R
A
R
R
A
G
V
D
A
L
H
M
D
P
A
A
Y
P
S
R
T
A
F
D
A
A
-
L
A
E
R
L
Q
A
Y
G
V
D
L
V
C
L
A
G
Y
M
R
L
V
R
G
P
M
L
T
A
F
P
N
R
I
L
N
I
H
P
S
L
L
P
A
F
P
G
L
E
A
Q
R
Q
A
L
E
H
G
V
K
V
A
G
C
T
V
H
F
V
T
A
G
V
D
E
G
P
I
I
L
Q
A
A
V
P
V
L
E
G
D
T
V
E
D
L
R
R
R
I
L
A
E
E
H
R
I
Y
P
E
A
I
R
L
F
A
E
-------
G
R
L
V
I
E
G
R
R
V
R
I
-
4
PsiBlast_PDB
72.74
43%
-137
- C3 -
4DS3
5
?
A:
[9-202]
-------------
R
V
V
I
F
I
S
G
G
G
S
N
M
E
A
L
I
R
A
-
A
-
Q
A
P
G
F
P
A
E
I
V
A
--
V
F
S
D
K
A
E
-
A
G
G
L
--
A
K
A
E
A
A
G
I
A
T
Q
V
F
K
R
K
D
F
A
S
K
E
A
H
E
D
A
-
I
L
A
A
L
D
V
L
K
P
D
I
I
C
L
A
G
Y
M
R
L
L
S
G
R
F
I
A
P
Y
E
G
R
I
L
N
I
H
P
S
L
L
P
L
F
P
G
L
H
T
H
Q
R
A
L
D
A
G
M
K
L
A
G
C
T
V
H
L
V
T
E
--
D
E
G
P
I
L
A
Q
A
A
V
P
V
L
D
G
D
T
A
E
T
L
A
A
R
V
L
K
A
E
H
R
L
Y
P
L
A
L
Q
K
F
A
---------------------
101
HHSearch
72.66
37%
-134
- C3 -
4ZZ1
2
A:
[2-192]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
R
E
P
-
N
S
S
A
Q
I
D
I
--
V
I
S
N
K
A
A
-
V
A
G
L
--
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
-
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
G
T
V
Q
L
---------------
6
PsiBlast_PDB
71.54
36%
-122
- C3 -
3P9X
6
?
A:
[4-186]
-------------
R
V
A
I
F
A
S
G
S
G
T
N
A
E
A
I
I
Q
S
Q
K
-
A
G
-
Q
L
P
C
E
V
A
L
--
L
I
T
D
K
-
P
G
A
K
V
V
--
E
R
V
K
V
H
E
I
P
V
C
A
L
D
P
K
T
Y
P
S
K
E
A
Y
E
I
E
-
V
V
Q
Q
L
K
E
K
Q
I
D
F
V
V
L
A
G
Y
M
R
L
V
G
P
T
L
L
G
A
Y
E
G
R
I
V
N
I
H
P
S
L
L
P
A
F
P
G
L
H
A
I
E
Q
A
I
R
A
N
V
K
V
T
G
V
T
I
H
Y
V
D
E
G
M
D
T
G
P
I
I
A
Q
E
A
V
S
I
E
E
E
D
T
L
E
T
L
T
T
K
I
Q
A
V
E
H
R
L
Y
P
A
T
L
H
K
L
----------------------
99
HHSearch
71.44
35%
-121
- C3 -
3P9X
6
?
A:
[3-192]
------------
K
R
V
A
I
F
A
S
G
S
G
T
N
A
E
A
I
I
Q
S
-
Q
K
A
G
-
Q
L
P
C
E
V
A
L
--
L
I
T
D
K
P
G
-
A
K
V
V
--
E
R
V
K
V
H
E
I
P
V
C
A
L
D
P
K
T
Y
P
S
K
E
A
Y
E
I
E
-
V
V
Q
Q
L
K
E
K
Q
I
D
F
V
V
L
A
G
Y
M
R
L
V
G
P
T
L
L
G
A
Y
E
G
R
I
V
N
I
H
P
S
L
L
P
A
F
P
G
L
H
A
I
E
Q
A
I
R
A
N
V
K
V
T
G
V
T
I
H
Y
V
D
E
G
M
D
T
G
P
I
I
A
Q
E
A
V
S
I
E
E
E
D
T
L
E
T
L
T
T
K
I
Q
A
V
E
H
R
L
Y
P
A
T
L
H
K
L
L
S
K
A
E
N
----------------
7
PsiBlast_PDB
71.18
35%
-130
- C3 -
2YWR
5
?
A:
[3-199]
-------------
K
I
G
V
L
V
S
G
R
G
S
N
L
Q
A
I
I
D
A
I
E
-
S
G
-
K
V
N
A
S
I
E
L
--
V
I
S
D
N
P
K
-
A
Y
A
I
--
E
R
C
K
K
H
N
V
E
C
K
V
I
Q
R
K
E
F
P
S
K
K
E
F
E
E
R
-
M
A
L
E
L
K
K
K
G
V
E
L
V
V
L
A
G
F
M
R
I
L
S
H
N
F
L
K
Y
F
P
N
K
V
I
N
I
H
P
S
L
I
P
A
F
Q
G
L
H
A
Q
K
Q
A
V
E
F
G
V
K
F
S
G
C
T
V
H
I
V
D
E
S
V
D
A
G
P
V
I
V
Q
A
V
V
P
V
L
P
E
D
D
E
N
T
L
A
D
R
I
L
K
W
E
H
K
I
L
P
Q
T
V
Q
W
F
A
Q
D
R
I
I
I
D
-
G
R
K
V
I
V
-------
18
PsiBlast_PDB
71.11
37%
-123
- C3 -
1RC1
2
PUR2_HUMAN
A:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
23
PsiBlast_CBE
71.09
36%
-122
- C3 -
3P9X
5
?
B:
[4-186]
-------------
R
V
A
I
F
A
S
G
S
G
T
N
A
E
A
I
I
Q
S
Q
K
-
A
G
-
Q
L
P
C
E
V
A
L
--
L
I
T
D
K
-
P
G
A
K
V
V
--
E
R
V
K
V
H
E
I
P
V
C
A
L
D
P
K
T
Y
P
S
K
E
A
Y
E
I
E
-
V
V
Q
Q
L
K
E
K
Q
I
D
F
V
V
L
A
G
Y
M
R
L
V
G
P
T
L
L
G
A
Y
E
G
R
I
V
N
I
H
P
S
L
L
P
A
F
P
G
L
H
A
I
E
Q
A
I
R
A
N
V
K
V
T
G
V
T
I
H
Y
V
D
E
G
M
D
T
G
P
I
I
A
Q
E
A
V
S
I
E
E
E
D
T
L
E
T
L
T
T
K
I
Q
A
V
E
H
R
L
Y
P
A
T
L
H
K
L
----------------------
34
PsiBlast_CBE
71.06
37%
-123
- C3 -
1RBQ
3
PUR2_HUMAN
B:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
102
HHSearch
70.75
36%
-130
- C3 -
2YWR
5
?
A:
[1-192]
-----------
M
L
K
I
G
V
L
V
S
G
R
G
S
N
L
Q
A
I
I
D
A
-
I
E
S
G
-
K
V
N
A
S
I
E
L
--
V
I
S
D
N
P
K
-
A
Y
A
I
--
E
R
C
K
K
H
N
V
E
C
K
V
I
Q
R
K
E
F
P
S
K
K
E
F
E
E
R
-
M
A
L
E
L
K
K
K
G
V
E
L
V
V
L
A
G
F
M
R
I
L
S
H
N
F
L
K
Y
F
P
N
K
V
I
N
I
H
P
S
L
I
P
A
F
Q
G
L
H
A
Q
K
Q
A
V
E
F
G
V
K
F
S
G
C
T
V
H
I
V
D
E
S
V
D
A
G
P
V
I
V
Q
A
V
V
P
V
L
P
E
D
D
E
N
T
L
A
D
R
I
L
K
W
E
H
K
I
L
P
Q
T
V
Q
W
F
A
Q
D
R
I
I
I
---------------
106
HHSearch
70.66
35%
-132
- C3 -
1JKX
1
PUR3_ECOLI
A:
[1-199]
------------
M
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
-
C
K
T
N
-
K
I
K
G
T
V
R
A
--
V
F
S
N
K
A
D
-
A
F
G
L
--
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
-
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
D
G
R
L
K
M
H
-
E
N
A
A
W
L
D
------
12
PsiBlast_PDB
70.57
37%
-122
- C3 -
1NJS
3
PUR2_HUMAN
A:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
14
PsiBlast_PDB
70.51
37%
-123
- C3 -
1RBQ
3
PUR2_HUMAN
A:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
31
PsiBlast_CBE
70.50
37%
-122
- C3 -
1RBY
2
PUR2_HUMAN
B:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
9
PsiBlast_PDB
70.35
37%
-123
- C3 -
4ZZ2
2
A:
[2-187]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
13
PsiBlast_PDB
70.20
37%
-123
- C3 -
1RBM
3
PUR2_HUMAN
A:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
36
PsiBlast_CBE
70.17
37%
-123
- C3 -
1NJS
2
B:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
15
PsiBlast_PDB
69.85
37%
-123
- C3 -
1RBY
2
PUR2_HUMAN
A:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
33
PsiBlast_CBE
69.63
37%
-122
- C3 -
1RBQ
3
PUR2_HUMAN
C:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
27
PsiBlast_CBE
69.61
37%
-121
- C3 -
1RC0
1
B:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
30
PsiBlast_CBE
69.60
37%
-122
- C3 -
1RBY
2
PUR2_HUMAN
C:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
10
PsiBlast_PDB
69.39
37%
-122
- C3 -
4ZZ3
2
A:
[2-187]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
29
PsiBlast_CBE
69.28
37%
-122
- C3 -
1RBY
1
D:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
58
PsiBlast_CBE
69.26
36%
-129
- C3 -
1CDE
2
PUR3_ECOLI
A:
[2-185]
-------------
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
-
C
K
T
N
-
K
I
K
G
T
V
R
A
--
V
F
S
N
K
A
D
-
A
F
G
L
--
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
-
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
---------------------
24
PsiBlast_CBE
69.26
37%
-126
- C3 -
4EW3
4
A:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
20
PsiBlast_PDB
69.25
37%
-127
- C3 -
4EW2
4
A:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
-
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
8
PsiBlast_PDB
69.24
37%
-122
- C3 -
4ZZ1
2
A:
[2-187]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
-
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
17
PsiBlast_PDB
69.17
37%
-120
- C3 -
1RC0
1
PUR2_HUMAN
A:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
26
PsiBlast_CBE
69.15
37%
-122
- C3 -
1RC1
3
B:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
35
PsiBlast_CBE
69.00
37%
-122
- C3 -
1RBM
4
B:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
57
PsiBlast_CBE
68.92
36%
-129
- C3 -
1CDE
2
PUR3_ECOLI
B:
[2-185]
-------------
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
-
C
K
T
N
-
K
I
K
G
T
V
R
A
--
V
F
S
N
K
A
D
-
A
F
G
L
--
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
-
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
---------------------
32
PsiBlast_CBE
68.70
37%
-120
- C3 -
1RBQ
2
D:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
28
PsiBlast_CBE
68.69
37%
-122
- C3 -
1RBZ
2
B:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
25
PsiBlast_CBE
68.39
37%
-121
- C3 -
1ZLY
2
A:
[1-186]
------------
A
R
V
A
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
56
PsiBlast_CBE
67.86
36%
-129
- C3 -
1CDE
2
PUR3_ECOLI
C:
[2-185]
-------------
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
-
C
K
T
N
-
K
I
K
G
T
V
R
A
--
V
F
S
N
K
A
D
-
A
F
G
L
--
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
-
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
---------------------
55
PsiBlast_CBE
67.80
36%
-129
- C3 -
1CDE
2
PUR3_ECOLI
D:
[2-185]
-------------
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
-
C
K
T
N
-
K
I
K
G
T
V
R
A
--
V
F
S
N
K
A
D
-
A
F
G
L
--
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
-
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
---------------------
62
PsiBlast_CBE
67.72
36%
-129
- C3 -
1C2T
2
PUR3_ECOLI
A:
[2-185]
-------------
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
-
C
K
T
N
-
K
I
K
G
T
V
R
A
--
V
F
S
N
K
A
D
-
A
F
G
L
--
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
-
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
---------------------
46
PsiBlast_CBE
67.66
36%
-130
- C3 -
1C3E
2
PUR3_ECOLI
A:
[2-185]
-------------
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
-
C
K
T
N
-
K
I
K
G
T
V
R
A
--
V
F
S
N
K
A
D
-
A
F
G
L
--
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
-
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
---------------------
104
HHSearch
67.62
32%
-138
- C3 -
3KCQ
1
?
A:
[7-203]
----------
K
E
L
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
-
F
S
T
--
E
S
S
V
V
I
S
C
--
V
I
S
N
N
A
E
-
A
R
G
L
--
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
R
K
P
-----
L
D
I
E
H
-
I
S
T
V
L
R
E
H
D
V
D
L
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
V
C
Y
P
K
G
V
K
L
I
A
Q
D
K
I
K
L
C
D
D
G
T
V
Q
C
T
------
61
PsiBlast_CBE
67.17
36%
-129
- C3 -
1C2T
2
PUR3_ECOLI
B:
[2-185]
-------------
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
-
C
K
T
N
-
K
I
K
G
T
V
R
A
--
V
F
S
N
K
A
D
-
A
F
G
L
--
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
-
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
---------------------
37
PsiBlast_CBE
67.09
36%
-113
- C3 -
1MEN
1
C:
[16-197]
----------------
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
45
PsiBlast_CBE
67.08
36%
-129
- C3 -
1C3E
2
PUR3_ECOLI
B:
[2-185]
-------------
N
I
V
V
L
I
S
G
N
G
S
N
L
Q
A
I
I
D
A
-
C
K
T
N
-
K
I
K
G
T
V
R
A
--
V
F
S
N
K
A
D
-
A
F
G
L
--
E
R
A
R
Q
A
G
I
A
T
H
T
L
I
A
S
A
F
D
S
R
E
A
Y
D
R
E
-
L
I
H
E
I
D
M
Y
A
P
D
V
V
V
L
A
G
F
M
R
I
L
S
P
A
F
V
S
H
Y
A
G
R
L
L
N
I
H
P
S
L
L
P
K
Y
P
G
L
H
T
H
R
Q
A
L
E
N
G
D
E
E
H
G
T
S
V
H
F
V
T
D
E
L
D
G
G
P
V
I
L
Q
A
K
V
P
V
F
A
G
D
S
E
D
D
I
T
A
R
V
Q
T
Q
E
H
A
I
Y
P
L
V
I
S
W
F
A
---------------------
38
PsiBlast_CBE
66.90
36%
-115
- C3 -
1MEN
1
PUR2_HUMAN
B:
[16-197]
----------------
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
40
PsiBlast_CBE
66.81
36%
-121
- C3 -
1MEJ
1
C:
[16-197]
----------------
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
GL
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
39
PsiBlast_CBE
66.41
36%
-112
- C3 -
1MEN
1
PUR2_HUMAN
A:
[16-197]
----------------
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
42
PsiBlast_CBE
66.32
36%
-121
- C3 -
1MEJ
1
PUR2_HUMAN
A:
[16-197]
----------------
V
L
I
S
G
T
G
S
N
L
Q
A
L
I
D
S
-
T
-
R
E
-
P
N
S
S
A
Q
I
D
--
I
V
I
S
N
-
K
-
A
A
V
A
G
L
D
K
A
E
R
A
G
I
P
T
R
V
I
N
H
K
L
Y
K
N
R
V
E
F
D
S
A
-
I
D
L
V
L
E
E
F
S
I
D
I
V
C
L
A
G
F
M
R
I
L
S
G
P
F
V
Q
K
W
N
G
K
M
L
N
I
H
P
S
L
L
P
S
F
K
G
S
N
A
H
E
Q
A
L
E
T
G
V
T
V
T
G
C
T
V
H
F
V
A
E
D
V
D
A
G
Q
I
I
L
Q
E
A
V
P
V
K
R
G
D
T
V
A
T
L
S
E
R
V
K
L
A
E
H
K
I
F
P
A
A
L
Q
L
V
A
S
--------------------
64
PsiBlast_CBE
61.74
36%
-121
- C3 -
3KCQ
1
?
C:
[10-177]
-------------
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
-
F
-
S
T
-
E
E
S
S
V
V
I
S
C
V
I
S
N
N
A
-
E
-
A
R
G
L
--
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
------
R
K
P
L
D
I
E
H
I
S
T
V
L
R
E
H
D
V
D
L
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
--------------------------------
66
PsiBlast_CBE
61.48
36%
-125
- C3 -
3KCQ
1
?
A:
[10-177]
-------------
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
-
F
-
S
T
--
E
S
S
V
V
I
S
C
V
I
S
N
N
A
-
E
-
A
R
G
L
--
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
------
R
K
P
L
D
I
E
H
I
S
T
V
L
R
E
H
D
V
D
L
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
--------------------------------
65
PsiBlast_CBE
60.89
36%
-122
- C3 -
3KCQ
1
?
B:
[10-177]
-------------
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
-
F
-
S
T
----
S
V
V
I
S
C
V
I
S
N
N
A
-
E
-
A
R
G
L
--
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
------
R
K
P
L
D
I
E
H
I
S
T
V
L
R
E
H
D
V
D
L
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
--------------------------------
63
PsiBlast_CBE
60.60
36%
-124
* C3 *
3KCQ
1
?
D:
[10-177]
-------------
R
V
G
V
L
I
S
G
R
G
S
N
L
E
A
L
A
K
A
-
F
-
S
----
S
S
V
V
I
S
CV
I
S
N
N
A
-
E
-
A
R
G
L
--
L
I
A
Q
S
Y
G
I
P
T
F
V
V
K
------
R
K
P
L
D
I
E
H
I
S
T
V
L
R
E
H
D
V
D
L
V
C
L
A
G
F
M
S
I
L
P
E
K
F
V
T
D
W
H
H
K
I
I
N
I
H
P
S
L
L
P
S
F
K
G
L
N
A
Q
E
Q
A
Y
K
A
G
V
K
I
A
G
C
T
L
H
Y
V
Y
Q
E
L
D
A
G
P
I
I
M
Q
A
A
V
P
V
L
R
E
D
T
A
E
S
L
A
S
R
I
L
A
A
E
H
--------------------------------