@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1017c: (2016-04-27 )
MSHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIFVRFHESVRGCDAFVLQSCPAPVNRWLMEQLIMIDALKRGSAKRITAVMPFYPYARQDKKHRGREPISARLIADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLTGYIRDNYPDGNMVVVSPDSGRVRIAEKWADALGGVPLAFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIAGAVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGAREVIVTNTLPIGEDKRFPQLTVLSIAPLLASTIRAVFENGSVTGLFDGDA
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80........90........100.......110........120.......130.......140.......150.......160..-.....170........180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.....-..290.-........300.......310.......320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSHDWTDNRK
N
L
M
L
F
AGRA
H
P
E
L
A
E
Q
V
A
K
EL
D
V
H
V
T
S
Q
D
A
R
E
FANG
E
I
F
V
R
F
H
E
SVRG
C
D
A
F
V
L
QSCPA
P
V
N
R
W
L
M
E
Q
L
I
M
I
D
A
L
KRGSA
K
R
I
T
A
VMPFYPYARQDKKHR-GREP
I
S
A
R
L
I
A
D
L
L
K
TAGA
D
R
I
V
T
V
D
L
H
T
D
Q
I
Q
G
FFDGP
V
D
H
MRGQ
N
L
L
T
G
Y
I
R-DNYPDG-
N
M
V
V
VSPDSG
R
V
R
I
A
E
K
W
A
D
A
LGGV
P
L
A
F
I
HKTRDPRV
P
N
Q
V
V
SNRVVGDVAG
R
T
C
V
L
I
DDMIDTGG
T
I
A
G
A
V
A
L
L
HNDGAG
D
V
I
I
A
ATHGVLS
D
P
A
A
Q
R
L
A
SCGA
R
E
V
I
V
TNTLPI-GED--K-RF
P
Q
L
T
V
L
S
I
A
P
L
L
A
S
T
I
R
A
V
F
ENG
S
V
T
G
LFDGDA
23
PsiBlast_CBE
97.92
46%
-151
- C3 -
3DAH
5
?
C:
[7-313]
----------
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
N
Y
P
D
---
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
-
N
C
D
L
A
I
I
D
K
R
R
--------
V
M
N
-
I
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
S
--
L
-
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
-------
1
PsiBlast_PDB
94.88
46%
-152
- C3 -
1DKU
3
KPRS_BACSU
A:
[9-316]
----------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
N
L
E
D
---
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
-
P
I
A
I
I
D
K
R
-----------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
--------
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
----
22
PsiBlast_CBE
94.86
46%
-150
- C3 -
1DKR
3
KPRS_BACSU
B:
[2-316]
-
S
N
Q
Y
G
D
--
K
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
N
L
E
D
---
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
-
P
I
A
I
I
D
K
R
-----------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
-
P
E
E
--
K
-
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
----
24
PsiBlast_CBE
94.67
46%
-150
- C3 -
3DAH
7
?
B:
[6-316]
---
D
------
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
N
Y
P
D
---
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
-
N
C
D
L
A
-------------------
I
G
E
V
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
S
--
L
-
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
F
----
21
PsiBlast_CBE
94.62
46%
-155
- C3 -
1DKU
3
KPRS_BACSU
B:
[9-316]
----------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
G
K
N
L
E
D
---
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
-
P
I
A
I
I
D
K
R
-----------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
--------
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
----
2
PsiBlast_PDB
94.50
46%
-149
- C3 -
3DAH
4
?
A:
[6-315]
---
D
------
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
K
Q
N
Y
P
D
---
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
-
N
C
D
L
A
I
----------------------
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
S
A
E
S
--
L
-
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
-----
10
PsiBlast_PDB
93.33
43%
-151
- C3 -
4LYG
2
PRPS1_HUMAN
A:
[3-313]
----------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
T
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
-
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
---------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
--
Q
E
D
K
M
K
-
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
----
74
HHSearch
93.30
45%
-151
- C3 -
1DKU
3
KPRS_BACSU
A:
[9-316]
----------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
-
G
K
-
N
L
E
-
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
-
A
P
I
A
I
I
D
K
R
-----------
M
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
L
--------
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
----
62
Fugue
93.25
46%
-147
- C3 -
1DKU
3
KPRS_BACSU
A:
[9-316]
----------
N
L
K
I
F
S
L
N
S
N
P
E
L
A
K
E
I
A
D
I
V
G
V
Q
L
G
K
C
S
V
T
R
F
S
D
G
E
V
Q
I
N
I
E
E
S
I
R
G
C
D
C
Y
I
I
Q
S
T
S
D
P
V
N
E
H
I
M
E
L
L
I
M
V
D
A
L
K
R
A
S
A
K
T
I
N
I
V
I
P
Y
Y
G
Y
A
R
Q
D
R
K
A
R
-
S
R
E
P
I
T
A
K
L
F
A
N
L
L
E
T
A
G
A
T
R
V
I
A
L
D
L
H
A
P
Q
I
Q
G
F
F
D
I
P
I
D
H
L
M
G
V
P
I
L
G
E
Y
F
E
-
G
K
N
L
E
--
D
I
V
I
V
S
P
D
H
G
G
V
T
R
A
R
K
L
A
D
R
L
K
A
-
P
I
A
I
I
D
K
R
M
-----------
N
I
V
G
N
I
E
G
K
T
A
I
L
I
D
D
I
I
D
T
A
G
T
I
T
L
A
A
N
A
L
V
E
N
G
A
K
E
V
Y
A
C
C
T
H
P
V
L
S
G
P
A
V
E
R
I
N
N
S
T
I
K
E
L
V
V
T
N
S
I
K
-------
L
-
K
I
E
R
F
K
Q
L
S
V
G
P
L
L
A
E
A
I
I
R
V
H
E
Q
Q
S
V
S
Y
L
F
----
31
PsiBlast_CBE
92.93
43%
-151
- C3 -
4LYG
3
PRPS1_HUMAN
B:
[3-313]
----------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
T
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
-
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
R
--
K
-----
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
--
Q
E
D
K
M
K
-
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
----
75
HHSearch
92.82
45%
-145
- C3 -
3DAH
4
?
A:
[6-315]
---------
D
G
L
M
V
F
T
G
N
A
N
P
A
L
A
Q
E
V
V
K
I
L
G
I
P
L
G
K
A
M
V
S
R
F
S
D
G
E
I
Q
V
E
I
Q
E
N
V
R
G
K
D
V
F
V
L
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
M
I
M
V
D
A
L
K
R
A
S
A
G
R
I
T
A
A
I
P
Y
F
G
Y
A
R
Q
D
R
R
P
R
S
A
R
V
A
I
S
A
K
V
V
A
N
M
L
E
I
A
G
V
E
R
I
I
T
M
D
L
H
A
D
Q
I
Q
G
F
F
D
I
P
V
D
N
I
Y
A
T
P
I
L
L
G
D
L
R
-
K
Q
-
N
Y
P
-
D
L
L
V
V
S
P
D
V
G
G
V
V
R
A
R
A
L
A
K
Q
L
N
-
C
D
L
A
I
----------------------
E
G
R
T
C
V
I
M
D
D
M
V
D
T
A
G
T
L
C
K
A
A
Q
V
L
K
E
R
G
A
K
Q
V
F
A
Y
A
T
H
P
V
L
S
G
G
A
A
D
R
I
A
A
S
A
L
D
E
L
V
V
T
D
T
I
P
L
-
S
A
E
--
S
L
A
C
P
K
I
R
A
L
S
S
A
G
L
L
A
E
T
F
S
R
I
R
R
G
D
S
V
M
S
L
-----
7
PsiBlast_PDB
92.73
43%
-149
- C3 -
3EFH
4
PRPS1_HUMAN
A:
[3-313]
----------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
-
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
R
--
K
-------
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
--
Q
E
D
K
M
K
-
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
----
13
PsiBlast_PDB
92.37
42%
-151
- C3 -
4LZO
3
PRPS1_HUMAN
A:
[3-313]
----------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
T
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
-
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
---------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
--
Q
E
D
K
M
K
-
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
----
25
PsiBlast_CBE
92.34
43%
-147
- C3 -
4LZN
3
PRPS1_HUMAN
A:
[3-313]
----------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
N
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
-
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
---------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
--
Q
E
D
K
M
K
-
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
----
27
PsiBlast_CBE
92.21
43%
-146
- C3 -
3EFH
4
PRPS1_HUMAN
B:
[3-313]
----------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
-
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
R
--
K
-------
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
--
Q
E
D
KM
K
-
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
----
9
PsiBlast_PDB
91.87
43%
-150
- C3 -
2H08
5
PRPS1_HUMAN
A:
[3-313]
----------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
M
A
E
P
A
V
L
K
W
I
R
-
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
R
--------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
--
Q
E
D
K
M
K
-
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
----
12
PsiBlast_PDB
91.80
43%
-146
- C3 -
4M0P
3
PRPS1_HUMAN
A:
[3-313]
----------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
T
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
-
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
---------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
--
Q
E
D
K
M
K
-
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
----
11
PsiBlast_PDB
91.66
43%
-148
- C3 -
2H07
5
PRPS1_HUMAN
A:
[3-313]
----------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
A
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
-
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
R
--------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
--
Q
E
D
K
M
K
-
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
----
26
PsiBlast_CBE
91.48
43%
-147
- C3 -
3S5J
3
PRPS1_HUMAN
A:
[3-313]
----------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
-
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
---------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
--
Q
E
D
K
M
K
-
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
----
3
PsiBlast_PDB
91.39
43%
-144
- C3 -
4S2U
1
?
A:
[4-310]
----------
D
M
K
L
F
A
G
N
A
T
P
E
L
A
Q
R
I
A
N
R
L
Y
T
S
L
G
D
A
A
V
G
R
F
S
D
G
E
V
S
V
Q
I
N
E
N
V
R
G
G
D
I
F
I
I
Q
S
T
C
A
P
T
N
D
N
L
M
E
L
V
V
M
V
D
A
L
R
R
A
S
A
G
R
I
T
A
V
I
P
Y
F
G
Y
A
R
Q
D
R
R
V
R
S
A
R
V
P
I
T
A
K
V
V
A
D
F
L
S
S
V
G
V
D
R
V
L
T
V
D
L
H
A
E
Q
I
Q
G
F
F
D
V
P
V
D
N
V
F
G
S
P
I
L
L
E
D
M
L
-
Q
L
N
L
D
--
N
P
I
V
V
S
P
D
I
G
G
V
V
R
A
R
A
I
A
K
L
L
N
D
T
D
M
A
I
I
D
K
R
R
P
R
A
N
V
S
Q
V
M
--
H
I
I
G
D
V
A
G
R
D
C
V
L
V
D
D
M
I
D
T
G
G
T
L
C
K
A
A
E
A
L
K
E
R
G
A
K
R
V
F
A
Y
A
T
H
P
I
F
S
G
N
A
A
N
N
L
R
N
S
V
I
D
E
V
V
V
C
D
T
I
P
L
-
S
D
E
I
-
K
-
S
L
P
N
V
R
T
L
T
L
S
G
M
L
A
E
A
I
R
R
I
S
N
E
E
S
I
--------
28
PsiBlast_CBE
90.61
43%
-147
- C3 -
2HCR
8
PRPS1_HUMAN
B:
[3-313]
----------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
-
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
---------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
--
Q
E
D
K
M
K
-
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
----
6
PsiBlast_PDB
90.43
43%
-146
- C3 -
2HCR
8
PRPS1_HUMAN
A:
[3-313]
----------
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
G
L
E
L
G
K
V
V
T
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
E
I
N
D
N
L
M
E
L
L
I
M
I
N
A
C
K
I
A
S
A
S
R
V
T
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
K
-
S
R
A
P
I
S
A
K
L
V
A
N
M
L
S
V
A
G
A
D
H
I
I
T
M
D
L
H
A
S
Q
I
Q
G
F
F
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
W
I
R
-
E
N
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
R
V
T
S
I
A
D
R
L
-
N
V
D
F
A
L
I
H
K
E
R
--------
D
R
M
V
L
V
G
D
V
K
D
R
V
A
I
L
V
D
D
M
A
D
T
C
G
T
I
C
H
A
A
D
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
F
S
G
P
A
I
S
R
I
N
N
A
C
F
E
A
V
V
V
T
N
T
I
P
--
Q
E
D
K
M
K
-
H
C
S
K
I
Q
V
I
D
I
S
M
I
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Y
L
F
----
19
PsiBlast_PDB
68.71
31%
-135
- C3 -
1U9Z
3
KPRS_METJA
A:
[1-266]
-----------
M
I
V
V
S
G
S
Q
S
Q
N
L
A
F
K
V
A
K
L
L
N
T
K
L
T
R
V
E
Y
K
R
F
P
D
N
E
I
Y
V
R
I
V
D
E
I
N
D
D
E
A
V
I
I
N
T
Q
K
N
Q
-
N
D
A
I
V
E
T
I
L
L
C
D
A
L
R
D
E
G
V
K
K
I
T
L
V
A
P
Y
L
A
Y
A
R
Q
D
K
K
F
N
-
P
G
E
A
I
S
I
R
A
L
A
K
I
Y
S
N
I
-
V
D
K
L
I
T
I
N
P
H
E
T
H
I
K
D
F
F
T
I
P
F
I
Y
G
D
A
V
P
K
L
A
E
Y
V
K
-
D
K
L
N
D
P
---
I
V
L
A
P
D
K
G
A
L
E
F
A
-
K
T
A
S
K
I
L
N
A
E
Y
D
Y
L
E
----------
I
A
P
K
T
L
--
D
A
K
D
R
D
V
F
I
V
D
D
I
I
S
T
G
G
T
M
A
T
A
V
K
L
L
K
E
Q
G
A
K
K
I
I
A
A
C
V
H
P
V
L
I
G
D
A
L
N
K
L
Y
S
A
G
V
E
E
V
V
G
T
D
T
----------------------------------------------
43
PsiBlast_CBE
68.15
31%
-134
- C3 -
1U9Z
3
KPRS_METJA
C:
[1-266]
-----------
M
I
V
V
S
G
S
Q
S
Q
N
L
A
F
K
V
A
K
L
L
N
T
K
L
T
R
V
E
Y
K
R
F
P
D
N
E
I
Y
V
R
I
V
D
E
I
N
D
D
E
A
V
I
I
N
T
Q
K
N
Q
-
N
D
A
I
V
E
T
I
L
L
C
D
A
L
R
D
E
G
V
K
K
I
T
L
V
A
P
Y
L
A
Y
A
R
Q
D
K
K
F
N
-
P
G
E
A
I
S
I
R
A
L
A
K
I
Y
S
N
I
-
V
D
K
L
I
T
I
N
P
H
E
T
H
I
K
D
F
F
T
I
P
F
I
Y
G
D
A
V
P
K
L
A
E
Y
V
K
-
D
K
L
N
D
P
---
I
V
L
A
P
D
K
G
A
L
E
F
A
-
K
T
A
S
K
I
L
N
A
E
Y
D
Y
L
E
----------
I
A
P
K
T
L
--
D
A
K
D
R
D
V
F
I
V
D
D
I
I
S
T
G
G
T
M
A
T
A
V
K
L
L
K
E
Q
G
A
K
K
I
I
A
A
C
V
H
P
V
L
I
G
D
A
L
N
K
L
Y
S
A
G
V
E
E
V
V
G
T
D
T
----------------------------------------------
44
PsiBlast_CBE
67.93
31%
-135
- C3 -
1U9Z
3
KPRS_METJA
B:
[1-266]
-----------
M
I
V
V
S
G
S
Q
S
Q
N
L
A
F
K
V
A
K
L
L
N
T
K
L
T
R
V
E
Y
K
R
F
P
D
N
E
I
Y
V
R
I
V
D
E
I
N
D
D
E
A
V
I
I
N
T
Q
K
N
Q
-
N
D
A
I
V
E
T
I
L
L
C
D
A
L
R
D
E
G
V
K
K
I
T
L
V
A
P
Y
L
A
Y
A
R
Q
D
K
K
F
N
-
P
G
E
A
I
S
I
R
A
L
A
K
I
Y
S
N
I
-
V
D
K
L
I
T
I
N
P
H
E
T
H
I
K
D
F
F
T
I
P
F
I
Y
G
D
A
V
P
K
L
A
E
Y
V
K
-
D
K
L
N
D
P
---
I
V
L
A
P
D
K
G
A
L
E
F
A
-
K
T
A
S
K
I
L
N
A
E
Y
D
Y
L
E
----------
I
A
P
K
T
L
--
D
A
K
D
R
D
V
F
I
V
D
D
I
I
S
T
G
G
T
M
A
T
A
V
K
L
L
K
E
Q
G
A
K
K
I
I
A
A
C
V
H
P
V
L
I
G
D
A
L
N
K
L
Y
S
A
G
V
E
E
V
V
G
T
D
T
----------------------------------------------
42
PsiBlast_CBE
67.56
31%
-135
- C3 -
1U9Z
3
KPRS_METJA
D:
[1-266]
-----------
M
I
V
V
S
G
S
Q
S
Q
N
L
A
F
K
V
A
K
L
L
N
T
K
L
T
R
V
E
Y
K
R
F
P
D
N
E
I
Y
V
R
I
V
D
E
I
N
D
D
E
A
V
I
I
N
T
Q
K
N
Q
-
N
D
A
I
V
E
T
I
L
L
C
D
A
L
R
D
E
G
V
K
K
I
T
L
V
A
P
Y
L
A
Y
A
R
Q
D
K
K
F
N
-
P
G
E
A
I
S
I
R
A
L
A
K
I
Y
S
N
I
-
V
D
K
L
I
T
I
N
P
H
E
T
H
I
K
D
F
F
T
I
P
F
I
Y
G
D
A
V
P
K
L
A
E
Y
V
K
-
D
K
L
N
D
P
---
I
V
L
A
P
D
K
G
A
L
E
F
A
-
K
T
A
S
K
I
L
N
A
E
Y
D
Y
L
E
----------
I
A
P
K
T
L
--
D
A
K
D
R
D
V
F
I
V
D
D
I
I
S
T
G
G
T
M
A
T
A
V
K
L
L
K
E
Q
G
A
K
K
I
I
A
A
C
V
H
P
V
L
I
G
D
A
L
N
K
L
Y
S
A
G
V
E
E
V
V
G
T
D
T
----------------------------------------------