@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1077: (2016-04-28 )
MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKDRIAVKMIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSEDKRNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYANPEGPASHYVTTGPEIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSGGRVRIVGADPEGSVYSGGAGRPYLVEGVGEDFWPAAYDPSVPDEIIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVAEEAGPDALIVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGALPALVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRAKLADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVGVITRYDLLGFLSEGAGRR
Atome Classification :
(59 SA)
------------------------------------.........10........20.---...---.-------.--..---30........40........50........60..--.-.--..-.-.70........80........90........100.......110.......------------120--.......----..130.......140.......150.......160.......170.......180.......190.......-200.-.....-.210-.------....---.------.------.------220.......230.......240.......250.......260.......270.......280--.-.---.-...-..290.......300..-.....310.......320-.......330.......340-.-......350.......360.......370.......380.......390.......400.......410.......420.......430........440---..-----..----.--...------.450.......460..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------M
R
I
A
Q
H
I
S
E
L
IGGT
P
L
V
R
L
NSV---VPD---G-------A--G
T
---
V
A
A
K
V
E
Y
LNPGGSSK
D
R
I
A
V
K
M
I
E
A
AEASGQLKP--G-
G
--
T
I
-
V
-EPTSGNTG
V
G
L
A
L
V
A
QRRG
Y
K
C
V
F
VCPDKVSEDKR
N
V
L
I
A
YG
A
E
V
V
V
CPTA------------V----PPHDPAS----
Y
Y
S
V
S
D
R
L
V
R
D
IDGAWKPDQYANPEGPASHYVTTGP
E
I
WADTEG
K
V
T
H
F
V
A
GIGTGGTIT
G
A
G
R
Y
L
K
E
VSG
G
-
R
V
R
I
-
V
G
ADP-EGS--V------YSGG---A------G------R------
P
Y
L
VEGVGEDFWPAAYDPSVPD
E
I
I
A
VSDSD
S
F
D
M
T
R
R
L
A
R
E
E
A
M
L
VGGS
C
G
M
A
V
V
A
A
L
K
V
A
---
E
-E---A-GP
D
-
A
L
I
V
V
L
LPDGG
R
G
Y
M
S
K
-
I
F
N
D
A
W
M
S
S
Y
G
F
L
R
S
RLD-GSTE
Q
S
T
V
G
D
V
L
R
RKSGAL
P
-
A
-
L
VHTH
P
S
E
T
V
R
D
A
I
G
I
L
R
EYGVSQMPVVGAEPPV
M
A
G
E
VAGS
V
S
E
R
E
L
L
S
A
V
F
EG
R
A
K
L
A
D
A
V
S
A
HMSPP
L
R
M
IG
A
G
E
L
V
S
A
A
G
K
A
LR-DW
D
A
L
M
V
V
E-----EG-----K
P
----
V
--
G
V
I
------
T
R
Y
D
L
L
G
F
L
S
EGAGRR
101
HHSearch
91.94
39%
-73
- C2 -
4COO
12
CBS_HUMAN
A:
[98-560]
--------------------------------------
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
-------
G
LK
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
------------
A
----
R
F
D
S
P
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
--
G
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
------
L
A
E
P
EEL
N
QTE---
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
E
D
L
T
E
K
K
--
P
W
W
W
H
L
R
-
V
Q
E
L
G
L
S
-
A
-
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
D
E
A
-----
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
-
M
D
H
F
A
L
V
V
H
E----
Q
------
M
V
----
F
--
G
V
V
------
T
A
I
D
L
L
N
F
V
A
A
Q
E
R
--
102
HHSearch
90.45
36%
-69
- C2 -
3PC3
2
?
A:
[51-513]
---------------------------------------
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
---
P
A
S
---
D
GI-----
E
--
C
E
---
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
--
G
-
Y
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
------------
A
----
A
Y
D
S
P
E
G
----
L
I
Y
V
A
Q
Q
L
Q
R
E
T
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
V
P
--
S
C
Q
I
-
V
G
V
D
P
-
Y
G
S
--
I
------
L
A
R
P
---
A
ELNKTD
V
------
Q
------
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
---
R
-
K
---
L
-
K
K
G
-
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
-
F
V
S
D
N
W
M
E
A
R
N
F
K
E
P
V
N
E
-
H
G
---
H
W
W
W
S
L
A
-
I
A
E
L
E
L
P
A
P
-
P
V
I
L
K
S
D
A
T
V
G
E
A
I
A
L
M
K
K
H
R
V
D
Q
L
P
V
V
D
Q
D
D
----
G
S
V
L
G
V
V
G
Q
E
T
L
I
T
Q
I
V
S
M
N
R
Q
Q
S
D
P
A
I
K
A
L
N
K
R
V
I
R
L
N
E
S
E
I
L
G
K
L
A
R
V
L
E
-
V
D
P
S
V
L
I
L
G
K
N
PAG
K
V
-----
E
L
----
K
--
A
L
A
------
T
K
L
D
V
T
T
F
I
A
A
G
K
---
122
Fugue
89.46
35%
-64
- C2 -
3PC3
2
?
A:
[12-515]
YERPADFIDPGKPSKCKWHLGTAEKSP
H
I
H
R
G
I
AHR
Q
Q
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
---
P
A
S
---
D
GI-----
E
--
C
E
---
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
--
G
-
Y
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
------------
A
----
A
Y
D
S
P
E
G
----
L
I
Y
V
A
Q
Q
L
Q
R
E
T
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
Q
V
P
S
--
C
Q
I
-
V
G
V
D
P
-
Y
G
S
--
I
------
L
A
R
P
---
A
------
E
------
L
NKTDVQ
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
---
R
-
K
---
L
-
K
K
G
-
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
-
F
V
S
D
N
W
M
E
A
R
N
F
K
E
P
V
N
E
-
H
G
H
W
W
W
---
S
L
A
I
A
E
L
E
L
P
A
-
P
-
P
V
I
L
K
S
D
A
T
V
G
E
A
I
A
L
M
K
K
H
R
V
D
Q
L
P
V
V
D
Q
D
D
----
G
S
V
L
G
V
V
G
Q
E
T
L
I
T
Q
I
V
S
M
N
R
Q
Q
S
D
P
A
I
K
A
L
N
K
R
V
I
R
L
N
E
S
E
I
L
G
K
L
A
R
V
L
E
-
V
D
P
S
V
L
I
L
G
-----
K
N
PAG
K
V
E
L
----
K
--
A
L
A
------
T
K
L
D
V
T
T
F
I
A
A
G
K
Q
K
-
2
PsiBlast_PDB
89.39
39%
-70
- C2 -
4COO
12
CBS_HUMAN
A:
[97-556]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
------------
A
----
R
F
D
S
P
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
--
E
-
D
L
T
E
K
K
P
W
W
W
H
L
R
V
Q
E
L
G
L
S
-
A
-
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
D
E
-----
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
-----
Q
------------
M
VF
G
V
V
------
T
A
I
D
L
L
N
F
V
A
------
3
PsiBlast_PDB
89.27
39%
-72
- C2 -
4L0D
2
CBS_HUMAN
A:
[75-534]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
------------
A
----
R
F
D
S
P
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
--
E
-
D
-
T
E
K
K
P
W
W
W
H
L
R
V
Q
E
L
G
L
S
-
A
-
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
D
E
-----
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
-----
Q
------------
M
VF
G
V
V
------
T
A
I
D
L
L
N
F
V
A
------
24
PsiBlast_CBE
88.92
39%
-71
- C2 -
4L0D
2
CBS_HUMAN
B:
[75-534]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
------------
A
----
R
F
D
S
P
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
--
E
-
D
L
T
E
K
K
P
W
W
W
H
L
R
V
Q
E
L
G
L
S
-
A
-
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
D
E
-----
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
-----
Q
------------
M
VF
G
V
V
------
T
A
I
D
L
L
N
F
V
A
------
26
PsiBlast_CBE
88.81
39%
-71
- C2 -
4L3V
2
CBS_HUMAN
A:
[74-543]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
------------
A
----
R
F
D
S
P
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
--
E
-
D
L
T
E
K
K
P
W
W
W
H
L
R
V
Q
E
L
G
L
S
-
A
-
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
D
E
-----
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
--------------RQMV
F
--
G
V
V
------
T
A
I
D
L
L
N
F
V
A
------
23
PsiBlast_CBE
88.69
39%
-71
- C2 -
4COO
9
CBS_HUMAN
B:
[97-556]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
------------
A
----
R
F
D
S
P
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
----------
K
P
W
W
W
H
L
R
V
Q
E
L
G
L
S
-
A
-
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
D
E
-----
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
-----
Q
-------
Q
----
M
VF
G
V
V
------
T
A
I
D
L
L
N
F
V
A
------
4
PsiBlast_PDB
88.68
39%
-71
- C2 -
4L28
2
CBS_HUMAN
A:
[74-543]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
------------
A
----
R
F
D
S
P
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
--
E
-
D
-
T
E
K
K
P
W
W
W
H
L
R
V
Q
E
L
G
L
S
-
A
-
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
N
Q
A
P
V
V
D
E
-----
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
--------------QMV-
F
--
G
V
V
------
T
A
I
D
L
L
N
F
V
A
------
5
PsiBlast_PDB
88.58
39%
-72
- C2 -
4L3V
2
CBS_HUMAN
B:
[74-543]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
------------
A
----
R
F
D
S
P
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
--
E
-
D
L
T
E
K
K
P
W
W
W
H
L
R
V
Q
E
L
G
L
S
-
A
-
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
D
E
-----
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
--------------RQMV
F
--
G
V
V
------
T
A
I
D
L
L
N
F
V
A
------
21
PsiBlast_CBE
88.22
39%
-72
- C2 -
4PCU
4
CBS_HUMAN
B:
[75-534]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
------------
A
----
R
F
D
S
P
S
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
--
E
-
D
------
W
W
W
H
L
R
V
Q
E
L
G
L
S
-
A
-
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
D
E
-----
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
-----
Q
Q
-----
R
Q
----
M
VF
G
V
V
------
T
A
I
D
L
L
N
F
V
A
------
25
PsiBlast_CBE
88.16
39%
-70
- C2 -
4L3V
2
CBS_HUMAN
C:
[74-543]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
------------
A
----
R
F
D
S
P
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
--
E
-
D
L
T
E
K
K
P
W
W
W
H
L
R
V
Q
E
L
G
L
S
-
A
-
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
D
E
-----
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
--------------RQMV
F
--
G
V
V
------
T
A
I
D
L
L
N
F
V
A
------
22
PsiBlast_CBE
87.36
39%
-70
- C2 -
4L27
2
CBS_HUMAN
D:
[74-533]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
------------
A
----
R
F
D
S
P
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
--
E
-
D
-
T
E
K
K
P
W
W
W
H
L
R
V
Q
E
L
G
L
S
-
A
-
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
N
Q
A
P
V
V
-
E
-----
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
-----
Q
------------
M
VF
G
V
V
------
T
A
I
D
L
L
N
F
V
A
------
10
PsiBlast_PDB
86.07
35%
-62
- C2 -
3PC3
2
?
A:
[49-515]
-------------------------------------
Q
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
--
A
S
D
---
G
-------
I
--
E
C
E
--
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
--
G
-
Y
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
------------
A
----
A
Y
D
S
P
E
G
----
L
I
Y
V
A
Q
Q
L
Q
R
E
T
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
-
Q
V
P
-
S
C
Q
I
-
V
G
V
D
P
-
Y
G
S
--
I
------
L
A
R
P
---
A
------
E
LNKTDV
Q
------
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
---
R
-
K
---
L
-
K
K
G
-
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
-
F
V
S
D
N
W
M
E
A
R
N
F
----
K
E
-
P
V
N
E
H
G
H
W
W
W
S
L
A
I
A
E
L
E
L
P
-
A
P
P
V
I
L
K
S
D
A
T
V
G
E
A
I
A
L
M
K
K
H
R
V
D
Q
L
P
V
V
D
Q
D
----
D
G
S
V
L
G
V
V
G
Q
E
T
L
I
T
Q
I
V
S
M
N
R
Q
Q
S
D
P
A
I
K
A
L
N
K
R
V
I
R
L
N
E
S
E
I
L
G
K
L
A
R
V
L
--
E
V
D
P
S
V
L
I
L
-----
G
K
-----
N
P
----
A
--
G
K
V
E
L
K
A
L
A
T
K
L
D
V
T
T
F
I
A
A
G
K
Q
K
-
9
PsiBlast_PDB
85.49
35%
-66
- C2 -
3PC2
2
?
A:
[49-513]
-------------------------------------
Q
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
--
A
S
D
---
G
-------
I
--
E
C
E
--
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
--
G
-
Y
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
------------
A
----
A
Y
D
S
P
E
G
----
L
I
Y
V
A
Q
Q
L
Q
R
E
T
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
-
Q
V
P
-
S
C
Q
I
-
V
G
V
D
P
-
Y
G
S
--
I
------
L
A
R
P
---
A
------
E
LNKTDV
Q
------
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
---
R
-
K
---
L
-
K
K
G
-
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
-
F
V
S
D
N
W
M
E
A
R
N
F
----
K
E
-
P
V
N
E
H
G
H
W
W
W
S
L
A
I
A
E
L
E
L
P
-
A
P
P
V
I
L
K
S
D
A
T
V
G
E
A
I
A
L
M
K
K
H
R
V
D
Q
L
P
V
V
D
Q
D
----
D
G
S
V
L
G
V
V
G
Q
E
T
L
I
T
Q
I
V
S
M
N
R
Q
Q
S
D
P
A
I
K
A
L
N
K
R
V
I
R
L
N
E
S
E
I
L
G
K
L
A
R
V
L
--
E
V
D
P
S
V
L
I
L
-----
G
K
-----
N
P
----
A
--
G
K
V
E
L
K
A
L
A
T
K
L
D
V
T
T
F
I
A
A
G
K
---
11
PsiBlast_PDB
85.46
35%
-63
- C2 -
3PC4
3
?
A:
[49-515]
-------------------------------------
Q
I
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
--
A
S
D
---
G
-------
I
--
E
C
E
--
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
--
G
-
Y
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
------------
A
----
A
Y
D
S
P
E
G
----
L
I
Y
V
A
Q
Q
L
Q
R
E
T
P
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
Y
D
G
T
A
A
E
I
L
W
Q
L
D
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
E
-
Q
V
P
-
S
C
Q
I
-
V
G
V
D
P
-
Y
G
S
--
I
------
L
A
R
P
---
A
------
E
LNKTDV
Q
------
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
H
A
---
R
-
K
---
L
-
K
K
G
-
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
K
-
F
V
S
D
N
W
M
E
A
R
N
F
----
K
E
-
P
V
N
E
H
G
H
W
W
W
S
L
A
I
A
E
L
E
L
P
-
A
P
P
V
I
L
K
S
D
A
T
V
G
E
A
I
A
L
M
K
K
H
R
V
D
Q
L
P
V
V
D
Q
D
----
D
G
S
V
L
G
V
V
G
Q
E
T
L
I
T
Q
I
V
S
M
N
R
Q
Q
S
D
P
A
I
K
A
L
N
K
R
V
I
R
L
N
E
S
E
I
L
G
K
L
A
R
V
L
--
E
V
D
P
S
V
L
I
L
-----
G
K
-----
N
P
----
A
--
G
K
V
E
L
K
A
L
A
T
K
L
D
V
T
T
F
I
A
A
G
K
Q
K
-
1
PsiBlast_PDB
85.22
39%
-68
- C2 -
4PCU
4
CBS_HUMAN
A:
[75-534]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
--------------
A
----
R
F
D
S
P
S
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
E
--
E
-
D
L
--
K
K
P
W
W
W
H
L
R
V
Q
E
L
G
L
S
-
A
-
P
L
T
V
L
P
T
I
T
C
G
H
T
I
E
I
L
R
E
K
G
F
D
Q
A
P
V
V
D
E
-----
A
G
V
I
L
G
M
V
T
L
G
N
M
L
S
S
L
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Y
K
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
F
A
L
V
V
H
E
-----
Q
------------
M
VF
G
V
V
------
T
A
I
D
L
L
N
F
V
A
------
29
PsiBlast_CBE
76.59
44%
-71
- C2 -
1M54
2
CBS_HUMAN
D:
[32-355]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
-----------------------
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.14
44%
-70
- C2 -
1JBQ
2
CBS_HUMAN
A:
[97-419]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
-----------------------
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
75.67
44%
-69
- C2 -
1JBQ
2
CBS_HUMAN
B:
[97-419]
-------------------------------------
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
---
G
K
K
---
F
GL-----
K
--
C
E
---
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
-
I
-
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
-----------------------
E
S
----
H
V
G
V
A
W
R
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
C
D
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
E
K
C
P
G
--
C
R
I
-
I
G
V
D
P
-
E
G
S
--
I
LAEPEE
L
N
Q
T
---
E
------
Q
------
T
------
T
Y
E
V
E
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
T
V
A
V
A
V
K
A
A
---
Q
-
E
---
L
-
Q
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
K
-
F
L
S
D
R
W
M
L
Q
K
G
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
73.54
45%
-72
- C2 -
2EFY
2
?
A:
[7-297]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
---
V
E
P
---
D
-------
M
--
A
E
---
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
G
Q
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
-------------------
P
E
R
R
M
L
A
----
A
R
E
E
A
L
R
L
K
E
E
L
-
G
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
-
R
I
P
-
H
V
K
V
-
I
A
V
E
P
A
R
S
N
--
V
------
L
S
G
G
---
K
------
M
------
G
------
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
---
R
-
E
---
L
-
G
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
73.48
43%
-73
- C2 -
2ISQ
3
CYSK1_ARATH
A:
[2-308]
-------------------------------------
R
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
---
A
E
G
---
C
-------
V
--
G
R
---
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
-
E
--
S
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
-----------------------
D
P
A
K
G
M
K
G
A
I
A
K
A
E
E
I
L
A
K
T
P
N
G
Y
M
L
Q
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
-
Q
N
A
-
N
V
K
L
-
Y
G
V
E
P
V
E
S
A
--
I
------
L
S
G
G
---
K
------
P
------
G
------
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
RP
E
-
N
---
A
-
G
---
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
-
V
L
F
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
72.90
45%
-68
- C2 -
2EFY
2
?
B:
[7-297]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
---
V
E
P
---
D
-------
M
--
A
E
---
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
GQ
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
-------------------
P
E
R
R
M
L
A
----
A
R
E
E
A
L
R
L
K
E
E
L
-
G
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
-
R
I
P
-
H
V
K
V
-
I
A
V
E
P
A
R
S
N
--
V
------
L
S
G
G
---
K
------
M
------
G
------
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
---
R
-
E
---
L
-
G
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
72.33
45%
-70
- C2 -
1VE1
1
?
A:
[7-297]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
---
V
E
P
---
D
-------
M
--
A
E
---
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
G
Q
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
-------------------
P
E
R
R
M
L
A
----
A
R
E
E
A
L
R
L
K
E
E
L
-
G
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
-
R
I
P
-
H
V
K
V
-
I
A
V
E
P
A
R
S
N
--
V
------
L
S
G
G
---
K
------
M
------
G
------
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
---
R
-
E
---
L
-
G
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.11
46%
-68
- C2 -
3ZEI
4
CYSK_MYCTU
A:
[1-300]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
---
T
D
G
---
A
-------
V
--
A
D
---
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
-------------------
D
G
M
S
G
----
A
I
A
K
A
E
E
L
A
K
T
D
Q
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
-
R
K
P
-
S
A
R
F
-
V
A
V
E
P
-
A
A
S
P-
V
------
L
S
G
G
---
Q
------
K
------
G
------
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
RP
E
-
N
---
A
-
G
---
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
72.04
45%
-72
- C2 -
2ECO
2
?
A:
[7-297]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
---
V
E
P
---
D
-------
M
--
A
E
---
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
G
Q
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
-------------------
P
E
R
R
M
L
A
----
A
R
E
E
A
L
R
L
K
E
E
L
-
G
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
-
R
I
P
-
H
V
K
V
-
I
A
V
E
P
A
R
S
N
--
V
------
L
S
G
G
---
K
------
M
------
G
------
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
---
R
-
E
---
L
-
G
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.49
46%
-67
- C2 -
2Q3B
5
CYSK_MYCTU
A:
[4-303]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
---
T
D
G
---
A
-------
V
--
A
D
---
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
-------------------
D
G
M
S
G
----
A
I
A
K
A
E
E
L
A
K
T
D
Q
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
-
R
K
P
-
S
A
R
F
-
V
A
V
E
P
-
A
A
S
P-
V
------
L
S
G
G
---
Q
------
K
------
G
------
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
RRP
E
-
N
---
A
-
G
---
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.32
43%
-70
- C2 -
1Z7W
2
CYSK1_ARATH
A:
[4-310]
-------------------------------------
R
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
---
A
E
G
---
C
-------
V
--
G
R
---
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
-
E
--
S
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
-----------------------
D
P
A
K
G
M
K
G
A
I
A
K
A
E
E
I
L
A
K
T
P
N
G
Y
M
L
Q
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
-
Q
N
A
-
N
V
K
L
-
Y
G
V
E
P
V
E
S
A
--
I
------
L
S
G
G
---
K
------
P
------
G
------
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
RP
E
-
N
---
A
-
G
---
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
-
V
L
F
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
71.28
38%
-73
- C2 -
2BHS
1
CYSM_ECOLI
A:
[4-293]
------------------------------------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
---
G
P
D
---
N
-------
G
--
S
E
---
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
---------------
T
----
K
E
Q
G
M
E
G
----
A
R
D
L
A
L
E
M
A
N
R
G
E
G
K
L
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
Q
S
-
K
-
P
V
T
I
-
V
G
L
Q
P
E
E
G
S
--
S
------
I
P
G
I
---
R
------
R
------
W
------
P
T
-------
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
-----
K
---
A
-
N
P
D
-
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
71.13
42%
-69
- C2 -
4AEC
4
CYSKM_ARATH
B:
[111-412]
------------------------------------
L
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
I
---
A
K
G
---
C
-------
V
--
A
N
---
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
--
G
-
K
--
S
V
L
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
-----------------------
D
P
A
K
G
M
T
G
A
V
Q
K
A
E
E
I
L
K
N
T
P
D
A
Y
M
L
Q
Q
F
D
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
K
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
-
K
N
P
-
K
T
Q
V
-
I
G
V
E
P
T
E
S
D
--
I
------
L
S
G
G
---
K
------
P
------
G
------
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
K
RP
E
-
N
---
A
-
G
---
K
L
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
71.12
38%
-67
- C2 -
1FCJ
4
CYSK_SALTY
D:
[2-302]
-------------------------------------
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
---------
G
-------
N
--
G
R
---
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
KGMKGAIQKAEE
I
----
V
A
S
D
P
Q
K
----
Y
L
L
L
Q
--------------
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
PV
I
------
A
Q
A
L
---
A
------
G
------
E
EIKPG-
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
---
E
D
E
---
S
-
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
71.02
45%
-69
- C2 -
2ECQ
2
?
A:
[7-297]
----------------------------------------------
I
G
K
T
P
V
V
R
L
A
K
V
---
V
E
P
---
D
-------
M
--
A
E
---
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
G
Q
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
-------------------
P
E
R
R
M
L
A
----
A
R
E
E
A
L
R
L
K
E
E
L
-
G
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
-
R
I
P
-
H
V
K
V
-
I
A
V
E
P
A
R
S
N
--
V
------
L
S
G
G
---
K
------
M
------
G
------
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
---
R
-
E
---
L
-
G
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
70.97
43%
-69
- C2 -
1Z7Y
1
CYSK1_ARATH
A:
[4-310]
-------------------------------------
R
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
---
A
E
G
---
C
-------
V
--
G
R
---
V
A
A
K
L
E
M
M
E
P
C
S
S
V
A
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
-
E
--
S
V
L
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
-----------------------
D
P
A
K
G
M
K
G
A
I
A
K
A
E
E
I
L
A
K
T
P
N
G
Y
M
L
Q
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
-
Q
N
A
-
N
V
K
L
-
Y
G
V
E
P
V
E
S
A
--
I
------
L
S
G
G
---
K
------
P
------
G
------
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
Q
RP
E
-
N
---
A
-
G
---
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
-
V
L
F
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
70.74
38%
-70
- C2 -
2BHS
1
CYSM_ECOLI
D:
[4-292]
------------------------------------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
---
G
P
D
---
N
-------
G
--
S
E
---
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
---------------
T
----
K
E
Q
G
M
E
G
----
A
R
D
L
A
L
E
M
A
N
R
G
E
G
K
L
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
Q
S
-
K
-
P
V
T
I
-
V
G
L
Q
P
E
E
G
S
--
S
------
I
P
G
I
---
R
------
R
------
W
------
P
T
-------
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
-----
K
---
A
-
N
P
D
-
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
70.73
45%
-67
- C2 -
2Q3B
5
CYSK_MYCTU
A:
[4-303]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
---
T
D
G
---
A
-------
V
--
A
D
---
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
------------
D
----
G
M
S
G
-------
A
I
A
K
A
E
E
L
A
K
T
D
Q
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
R
K
P
--
S
A
R
F
-
V
A
V
E
P
-
A
A
S
--
P
------
V
L
S
G
G
--
Q
------
K
------
G
------
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
---
R
-
R
P--
E
-
N
A
G
-
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
70.68
44%
-63
- C2 -
1VE1
1
?
A:
[2-302]
-----------------------------------------
R
V
E
G
A
I
G
K
T
P
V
V
R
L
A
K
V
---
V
E
P
---
D
-------
M
--
A
E
---
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
GS
G
-
Q
--
V
I
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
------------
R
----
R
M
L
A
-------
A
R
E
E
A
L
R
L
K
E
E
-
L
G
A
F
M
P
D
Q
F
K
N
P
A
N
V
R
A
H
Y
E
T
T
G
P
E
L
Y
E
A
L
E
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
E
R
I
P
--
H
V
K
V
-
I
A
V
E
P
-
A
R
S
--
N
------
V
L
S
G
---
G
K
-----
M
------
G
------
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
---
R
-
E
---
L
-
G
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
-
P
L
Y
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
70.52
38%
-71
- C2 -
2BHS
1
CYSM_ECOLI
C:
[4-292]
------------------------------------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
---
G
P
D
---
N
-------
G
--
S
E
---
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
---------------
T
----
K
E
Q
G
M
E
G
----
A
R
D
L
A
L
E
M
A
N
R
G
E
G
K
L
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
Q
S
-
K
-
P
V
T
I
-
V
G
L
Q
P
E
E
G
S
--
S
------
I
P
G
I
---
R
------
R
------
W
------
P
T
-------
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
-----
K
---
A
-
N
P
D
-
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
70.46
42%
-69
- C2 -
1Z7W
2
CYSK1_ARATH
A:
[5-318]
--------------------------------------
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
---
A
E
G
---
C
-------
V
--
G
R
---
V
A
A
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
E
S
--
V
L
-
I
-
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
------------
K
----
G
M
K
G
-------
A
I
A
K
A
E
E
I
L
A
K
T
P
N
G
Y
M
L
Q
Q
F
E
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
K
G
T
G
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
E
Q
N
A
--
N
V
K
L
-
Y
G
V
E
P
-
V
E
S
--
A
------
I
L
S
G
G--
K
------
P
------
G
------
P
H
K
I
Q
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
A
A
A
A
A
I
K
L
A
---
Q
-
R
---
P
E
N
A
G
-
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
T
-
V
L
F
D
A
T
R
K
E
A
E
A
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
70.29
38%
-66
- C2 -
1FCJ
4
CYSK_SALTY
B:
[2-304]
-------------------------------------
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
---------
G
-------
N
--
G
R
---
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
KGMKGAIQKAEE
I
----
V
A
S
D
P
Q
K
----
Y
L
L
L
Q
--------------
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
PV
I
------
A
Q
A
L
---
A
------
G
------
E
EIKPG-
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
---
E
D
E
---
S
-
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.15
46%
-60
- C2 -
2Q3D
2
CYSK_MYCTU
A:
[4-309]
------------------------------------
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
---
T
D
G
---
A
-------
V
--
A
D
---
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
I
-
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
-------------------
D
G
M
S
G
----
A
I
A
K
A
E
E
L
A
K
T
D
Q
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
D
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
E
-
R
K
P
-
S
A
R
F
-
V
A
V
E
P
-
A
A
S
P-
V
------
L
S
G
G
---
Q
------
K
------
G
------
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
RP
E
-
N
---
A
-
G
---
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
S
T
P
L
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
70.01
38%
-69
- C2 -
1OAS
1
CYSK_SALTY
B:
[2-315]
-------------------------------------
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
---------
G
-------
N
--
G
R
---
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
KGMKGAIQKAEE
I
----
V
A
S
D
P
Q
K
----
Y
L
L
L
Q
--------------
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
PV
I
------
A
Q
A
L
---
A
------
G
------
E
EIKPG-
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
---
E
D
E
---
S
-
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
69.91
40%
-64
- C2 -
4LMA
3
?
A:
[8-314]
------------------------------------
M
R
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
I
----
P
Q
---
A
-------
E
--
G
C
L
G
R
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
P
--
E
-
T
--
T
V
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
G
S
-------------------
Q
G
M
K
G
----
A
I
L
R
A
Q
Q
I
V
D
S
I
P
G
A
Y
M
L
Q
Q
F
R
N
P
S
N
P
E
I
H
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
Q
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
S
R
K
P
S
--
F
Q
V
-
V
A
V
E
P
-
F
N
S
P-
V
------
I
S
G
G
---
N
------
P
------
G
------
P
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
---
Q
-
R
---
P
-
E
N
E
G
K
L
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
T
-
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
69.85
38%
-65
- C2 -
1FCJ
4
CYSK_SALTY
A:
[2-302]
-------------------------------------
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
---------
G
-------
N
--
G
R
---
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
KG
M
K
G
A
I
Q
K
A
E
E
I
----
V
A
S
D
P
Q
K
----
Y
L
L
L
Q
--------------
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
V
I
------
A
Q
A
L
---
A
------
G
------
E
E
I
K
P
G
-
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
---
E
D
E
---
S
-
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
69.39
40%
-63
- C2 -
4LMA
2
?
B:
[8-314]
------------------------------------
M
R
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
I
----
P
Q
---
A
-------
E
--
G
C
LGR
I
V
M
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
P
--
E
-
T
--
T
V
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
G
S
-------------------
Q
G
M
K
G
----
A
I
L
R
A
Q
Q
I
V
D
S
I
P
G
A
Y
M
L
Q
Q
F
R
N
P
S
N
P
E
I
H
R
L
T
T
A
E
E
I
W
Q
D
T
E
G
Q
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
S
R
K
P
S
--
F
Q
V
-
V
A
V
E
P
-
F
N
S
P-
V
------
I
S
G
G
---
N
------
P
------
G
------
P
H
K
I
Q
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
N
L
C
A
A
I
Q
L
A
---
Q
-
R
---
P
-
E
N
E
G
K
L
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
T
-
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
69.32
38%
-63
- C2 -
1FCJ
4
CYSK_SALTY
C:
[2-304]
-------------------------------------
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
---------
G
-------
N
--
G
R
---
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
KGMKGAIQKAEE
I
----
V
A
S
D
P
Q
K
----
Y
L
L
L
Q
--------------
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
PV
I
------
A
Q
A
L
---
A
------
G
------
E
EIKPG-
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
---
E
D
E
---
S
-
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
69.22
38%
-62
- C2 -
1D6S
2
CYSK_SALTY
A:
[2-315]
-------------------------------------
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
---------
G
-------
N
--
G
R
---
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
KG
M
K
G
A
I
Q
K
A
E
E
I
----
V
A
S
D
P
Q
K
----
Y
L
L
L
Q
--------------
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
V
I
------
A
Q
A
L
---
A
------
G
------
E
E
I
K
P
G
-
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
---
E
D
E
---
S
-
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
69.22
38%
-68
- C2 -
1OAS
1
CYSK_SALTY
A:
[2-315]
-------------------------------------
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
---------
G
-------
N
--
G
R
---
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
KG
M
K
G
A
I
Q
K
A
E
E
I
----
V
A
S
D
P
Q
K
----
Y
L
L
L
Q
--------------
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
V
I
------
A
Q
A
L
---
A
------
G
------
E
E
I
K
P
G
-
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
---
E
D
E
---
S
-
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
69.16
41%
-67
* C2 *
4AEC
3
CYSKM_ARATH
A:
[112-422]
-------------------------------------
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
I
---
A
K
G
---
C
-------
V
--
A
N
---
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
--
G
K
S
--
V
L
-
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
P
A
------------
K
----
G
M
T
G
-------
A
V
Q
K
A
E
E
I
L
K
N
T
P
D
A
Y
M
L
Q
Q
F
D
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
K
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
K
N
P
--
K
T
Q
V
-
I
G
V
E
P
-
T
E
S
--
D
------
I
L
S
G
G
--
K
------
P
------
G
------
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
---
K
-
R
P--
E
-
N
A
G
-
K
L
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
T
-
P
L
F
Q
S
I
R
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Fugue
69.12
40%
-62
- C2 -
1OAS
1
CYSK_SALTY
A:
[1-315]
------------------------------------
S
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
---------
G
-------
N
--
G
R
---
I
L
A
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
------------
K
------
G
M
K
G
A
----
I
Q
K
A
E
E
I
V
A
S
D
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
T
D
L
I
T
-
V
A
V
E
P
-
T
D
S
P-
V
------
I
A
Q
A
---
L
------
A
------
G
E
E
I
K
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
---
E
D
E
---
S
-
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
-----------------------------------------------------------------------------------------
A
L
F
A
D
L
F
-------------------------------------------------------------------------------------------
42
PsiBlast_CBE
68.58
42%
-69
- C2 -
4AEC
3
CYSKM_ARATH
A:
[111-412]
------------------------------------
L
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
I
---
A
K
G
---
C
-------
V
--
A
N
---
I
A
A
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
--
G
-
K
--
S
V
L
V
-
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
-----------------------
D
P
A
K
G
M
T
G
A
V
Q
K
A
E
E
I
L
K
N
T
P
D
A
Y
M
L
Q
Q
F
D
N
P
A
N
P
K
I
H
Y
E
T
T
G
P
E
I
W
D
D
T
K
G
K
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
E
-
K
N
P
-
K
T
Q
V
-
I
G
V
E
P
T
E
S
D
--
I
------
L
S
G
G
---
K
------
P
------
G
------
P
H
K
I
Q
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
A
A
A
A
A
I
K
V
A
K
RP
E
-
N
---
A
-
G
---
K
L
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
68.54
38%
-69
- C2 -
2BHS
1
CYSM_ECOLI
B:
[4-292]
------------------------------------------
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
---
G
P
D
---
N
-------
G
--
S
E
---
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
L
-
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
---------------
T
----
K
E
Q
G
M
E
G
----
A
R
D
L
A
L
E
M
A
N
R
G
E
G
K
L
L
-
D
Q
F
N
N
P
D
N
P
Y
A
H
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
E
Q
S
-
K
-
P
V
T
I
-
V
G
L
Q
P
E
E
G
S
--
S
------
I
P
G
I
---
R
------
R
------
W
------
P
T
-------
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
-----
K
---
A
-
N
P
D
-
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
68.53
40%
-53
- C2 -
4LMB
3
?
A:
[8-317]
------------------------------------
M
L
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
I
P
--
V
A
E
---
G
-------
V
K-
A
R
---
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
--
D
-
K
--
T
I
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
G
S
-------------------
Q
G
M
E
G
----
A
I
T
R
A
E
E
I
V
E
N
T
P
N
A
Y
S
L
Q
Q
F
R
N
P
A
N
P
K
I
H
R
E
T
T
A
E
E
I
W
A
D
T
D
G
L
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
P
-
R
R
P
-
Q
F
Q
A
-
I
A
V
E
P
-
S
N
S
P-
V
------
L
S
G
G
---
Q
------
P
------
G
------
P
H
K
I
Q
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
---
K
-
R
P--
E
-
N
E
D
-
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
K
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
68.22
37%
-78
- C2 -
4AIR
5
?
B:
[31-330]
-------------------------------------
N
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
L
----
N
N
---
T
-------
K
--
A
K
---
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
--
G
-
K
--
S
V
-
V
V
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
A
A
------------
L
-------
G
M
K
G
----
A
V
T
M
A
K
K
I
V
T
A
N
P
N
A
V
L
A
D
Q
F
A
T
K
Y
N
A
L
I
H
E
E
T
T
G
P
E
I
W
E
Q
T
N
H
N
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
K
M
-
G
S
-
H
A
R
I
-
V
A
V
E
P
M
E
-------------------------------------------------------
D
R
S
L
I
D
E
V
F
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
---
E
-
R
---
P
-
E
M
E
G
K
T
I
V
T
I
I
P
S
F
G
E
R
Y
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
67.80
38%
-62
- C2 -
1D6S
2
CYSK_SALTY
B:
[2-315]
-------------------------------------
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
---------
G
-------
N
--
G
R
---
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
-
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
KGMKGAIQKAEE
I
----
V
A
S
D
P
Q
K
----
Y
L
L
L
Q
--------------
Q
F
S
N
P
A
N
P
E
I
H
E
K
T
T
G
P
E
I
W
E
D
T
D
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
G
T
K
G
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
PV
I
------
A
Q
A
L
---
A
------
G
------
E
EIKPG-
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
---
E
D
E
---
S
-
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
67.79
39%
-56
- C2 -
4LMB
3
?
A:
[8-317]
------------------------------------
M
L
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
I
---
P
V
A
---
E
-------
G
VK
A
R
---
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
D-
K
-
T
--
I
L
-
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
G
S
------------
Q
----
G
M
E
G
-------
A
I
T
R
A
E
E
I
V
E
N
T
P
N
A
Y
S
L
Q
Q
F
R
N
P
A
N
P
K
I
H
R
E
T
T
A
E
E
I
W
A
D
T
D
G
L
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
P
R
R
P
--
Q
F
Q
A
-
I
A
V
E
P
-
S
N
S
--
P
------
V
L
S
G
---
G
Q
-----
P
------
G
------
P
H
K
I
Q
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
---
K
-
R
P--
E
-
N
E
D
-
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
-
A
L
F
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
66.52
32%
-64
- C2 -
5D84
1
SBNA_STAAE
A:
[8-319]
--------------------------------------
C
H
D
S
L
L
D
S
V
G
Q
T
P
M
V
Q
L
H
Q
L
---
F
P
------------
K
--
H
E
---
V
F
A
K
L
E
Y
M
N
P
G
G
S
M
K
D
R
P
A
K
Y
I
I
E
H
G
I
K
H
G
L
I
T
E
--
N
-
T
--
H
L
-
I
-
E
S
T
S
G
N
L
G
I
A
L
A
M
I
A
K
I
K
G
L
K
L
T
C
V
V
D
P
K
I
S
P
T
N
L
K
I
I
K
S
Y
G
A
N
V
E
M
V
E
E
P
------------
D
AHGG
Y
L
M
T
-------
R
I
A
K
V
Q
E
L
L
A
T
I
D
D
A
Y
W
I
N
Q
Y
A
N
E
L
N
W
Q
S
H
Y
H
G
A
G
T
E
I
V
E
T
I
K
Q
P
I
D
Y
F
V
A
P
V
S
T
T
G
S
I
M
G
M
S
R
K
I
K
E
V
H
P
--
N
A
Q
I
-
V
A
V
D
A
-
K
G
S
--
V
------
I
F
G
D
---
K
------
P
------
I
------
N
R
E
L
P
G
I
G
A
S
R
V
P
E
I
L
N
R
S
E
I
N
Q
V
I
H
V
D
D
Y
Q
S
A
L
G
C
R
K
L
I
D
Y
E
G
I
F
A
G
G
S
T
G
S
I
I
A
A
I
E
Q
L
I
---
T
-
S
---
I
-
E
E
G
-
A
T
I
V
T
I
L
P
D
R
G
D
R
Y
L
D
L
-
V
Y
S
D
T
W
L
E
K
M
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
66.20
37%
-59
- C2 -
3DWG
1
CYSM_MYCTU
A:
[3-317]
------------------------------------
M
T
R
Y
D
S
L
L
Q
A
L
G
N
T
P
L
V
G
L
Q
R
L
---
S
P
R
---
W
DDGRD
G
P
H
--
V
R
---
L
W
A
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
L
L
R
P
--
G
-
A
--
T
I
-
L
-
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
F
S
A
A
E
------------
G
----
G
S
N
T
-------
A
V
A
T
A
K
E
L
A
A
T
N
P
S
W
V
M
L
Y
Q
Y
G
N
P
A
N
T
D
S
H
Y
C
G
T
G
P
E
L
L
A
D
L
P
-
E
I
T
H
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
E
H
V
A
--
N
V
K
I
-
V
A
A
E
P
-
R
Y
G
--
E
------
G
V
Y
---------------------------
A
L
R
N
M
D
E
G
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
V
L
H
A
A
L
G
V
G
---
A
-
G
A
L
A
A
-
G
E
R
-
A
D
I
A
L
V
V
A
D
A
G
W
K
Y
L
S
T
-
G
A
Y
A
G
S
L
D
D
A
E
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
63.25
34%
-55
- C2 -
3BM5
4
?
B:
[11-314]
-------------------------------------
R
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
---
T
E
H
PRI
K
-------
K
--
G
T
R--
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
--
E
I
-
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
--
T
E
------------
G
----
K
K
G
M
P
G
A
----
I
E
E
V
N
K
M
I
K
E
N
P
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
H
Y
T
A
N
-
E
I
W
E
D
T
D
G
E
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
E
K
K
K
G
-
I
K
I
I
-
A
V
E
P
E
-
E
S
A
--
V
------
L
E
G
K
---
A
------
K
------
G
------
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
G
L
K
E
A
---
E
-
K
---
P
-
E
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
40.36
37%
-9
- C2 -
5HBG
1
CYSM_HELPY
B:
[1-302]
------------------------------------
M
M
I
I
T
T
M
Q
D
A
I
G
R
T
P
V
F
K
F
T
N
K
DYP
I
P
L
---
N
-------
S
--
A
----
I
Y
A
K
L
E
H
L
N
P
G
G
S
V
K
D
R
L
G
Q
Y
L
I
G
E
G
F
K
T
G
K
I
T
S
--
K
-
T
--
T
I
-
I
-
E
P
T
A
G
N
T
G
I
A
L
A
L
V
A
I
K
H
H
L
K
T
I
F
V
V
P
E
K
F
S
T
E
K
Q
Q
I
M
R
A
L
G
A
L
V
I
N
T
P
T
S
-------------------
E
G
I
S
G
----
A
I
K
K
S
K
E
L
A
E
S
I
P
D
S
Y
L
P
L
Q
F
E
N
P
D
N
P
A
A
Y
Y
H
T
L
A
P
E
I
V
Q
E
L
G
T
N
L
T
S
F
V
A
G
I
G
S
G
G
T
F
A
G
T
A
R
Y
L
K
E
R
I
P
A
--
I
R
L
-
I
G
V
E
P
-
E
G
S
--
I
------
L
N
G
G
---
E
------
P
------
G
------
P
H
E
I
E
G
I
G
V
E
F
I
P
P
F
F
E
N
L
D
I
D
G
F
E
T
I
S
D
E
E
G
F
S
Y
T
R
K
L
A
K
K
N
G
L
L
V
G
S
S
S
G
A
A
F
V
A
A
L
K
E
A
---
Q
-
R
---
L
-
P
E
G
-
S
Q
V
L
T
I
F
P
D
V
A
D
R
Y
L
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------