@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1079: (2016-04-28 )
MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDIADLLGDLEQALG
Atome Classification :
(35 SA)
.........10........20......-..30........40......-------..50------.-----........60........70........80........90........100.......110.......120..-.-....130..--.-....140.......150.......160.......170.--...-.--...180.......190........200.......210......-.-220-.......230----..--------------------------..--.--.--...240.......250.......260.......270.......280.......290.......300..-.....310.......320.......330.......340.......350.....---.---.---360--........370.......380......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSEDRTGHQGISGPAT
R
A
I
HAGYRPDP-ATG
A
V
N
V
P
I
Y
ASSTFAQDGV-------GGL-------R-----GG
F
E
YARTGN
P
T
R
A
A
L
E
A
S
L
A
A
V
EE
G
A
F
A
R
A
F
SSGM
A
A
T
D
C
A
L
R
A
MLRPG
D
H
V
VIPDDAYG
G
T
F
R
L
I
D
K
V
F
T
R-W-D
V
Q
YT
P
V
R
L
--A-DLDAVGAAITP
R
T
R
L
I
W
V
ETPTNP
L
L
S
I
A
D
I
T
A
I
A
-EL--GTD-R--S
A
K
V
L
V
DNTFA
S
P
A
L
-
Q
Q
P
L
R
LGA
D
V
V
L
HST
T
K
YIGGHSDVVG-
G
-
A
L
V-T
N
D
E
E
L
D
E
------
E
F
--------------------------
A
F
--
L
--Q--NGAGAVPG
P
F
D
A
Y
L
T
M
R
G
L
K
T
L
V
L
R
M
Q
RHSE
N
A
C
A
V
A
E
F
L
ADHPS
V
S
S
VLYPGLPSHP
G
H
E
I
A
A
R
Q
M
R-GFG
G
M
V
S
V
R
M
R
AG
R
R
A
A
Q
D
L
C
A
K
T
R
V
F
I
L
A
E
S
LG
G
V
E
S
L
I
EHPSAMTHASTAG---S---Q---LE---VP
D
D
L
V
R
L
SV
G
I
E
D
I
A
D
L
L
G
D
L
E
Q
ALG
22
PsiBlast_CBE
96.46
86%
-100
- C1 -
3QI6
4
?
B:
[14-392]
---------
R
F
A
G
L
A
T
R
A
I
H
S
G
Y
R
P
D
P
-
A
T
G
A
V
N
A
P
I
Y
A
S
S
T
F
A
Q
D
G
V
-------
G
G
L
-------
R
-----
G
G
Y
E
Y
A
R
T
G
N
P
T
R
T
A
L
E
A
A
L
A
A
V
E
D
A
A
F
G
R
A
F
S
S
G
M
A
A
A
D
C
A
L
R
A
M
L
R
P
G
D
H
V
V
I
P
D
D
A
Y
G
G
T
F
R
L
I
D
K
V
F
T
G
-
W
-
N
V
E
Y
T
P
V
A
L
--
A
-
D
L
D
A
V
R
A
A
I
R
P
T
T
R
L
I
W
V
E
T
P
T
N
P
L
L
S
I
A
D
I
A
G
I
A
-
Q
L
--
G
A
D
-
S
--
S
A
K
V
L
V
D
N
T
F
A
S
P
A
L
-
Q
Q
P
L
S
L
G
A
D
V
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
-
G
-
A
L
V
-
T
N
D
E
E
L
D
Q
------
S
F
--------------------------
A
F
--
L
--
Q
--
N
G
A
G
A
V
P
G
P
F
D
A
Y
L
T
M
R
G
L
K
T
L
V
L
R
M
Q
R
H
S
E
N
A
A
A
V
A
E
F
L
A
E
H
P
A
I
S
T
V
L
Y
P
G
L
P
S
H
P
G
H
A
V
A
A
R
Q
M
R
-
G
F
G
G
M
V
S
V
R
M
R
A
G
R
T
A
A
E
Q
L
C
A
K
T
N
I
F
I
L
A
E
S
L
G
S
V
E
S
L
I
E
H
P
S
A
M
T
-----
G
---
S
---
Q
---
L
E
---
V
P
D
D
L
V
R
L
S
V
G
I
E
D
V
A
D
L
L
D
D
L
K
Q
A
L
G
2
PsiBlast_PDB
95.64
86%
-100
- C1 -
3QI6
5
?
A:
[16-392]
-----------
A
G
L
A
T
R
A
I
H
S
G
Y
R
P
D
P
-
A
T
G
A
V
N
A
P
I
Y
A
S
S
T
F
A
Q
D
G
V
-------
G
G
L
-------
R
-----
G
G
Y
E
Y
A
R
T
G
N
P
T
R
T
A
L
E
A
A
L
A
A
V
E
D
A
A
F
G
R
A
F
S
S
G
M
A
A
A
D
C
A
L
R
A
M
L
R
P
G
D
H
V
V
I
P
D
D
A
Y
G
G
T
F
R
L
I
D
K
V
F
T
G
-
W
-
N
V
E
Y
T
P
V
A
L
--
A
-
D
L
D
A
V
R
A
A
I
R
P
T
T
R
L
I
W
V
E
T
P
T
N
P
L
L
S
I
A
D
I
A
G
I
A
-
Q
L
--
G
A
D
-
S
--
S
A
K
V
L
V
D
N
T
F
A
S
P
A
L
-
Q
Q
P
L
S
L
G
A
D
V
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
-
G
-
A
L
V
-
T
N
D
E
E
L
D
Q
------
S
F
--------------------------
A
F
--
L
--
Q
--
N
G
A
G
A
V
P
G
P
F
D
A
Y
L
T
M
R
G
L
K
T
L
V
L
R
M
Q
R
H
S
E
N
A
A
A
V
A
E
F
L
A
E
H
P
A
I
S
T
V
L
Y
P
G
L
P
S
H
P
G
H
A
V
A
A
R
Q
M
R
-
G
F
G
G
M
V
S
V
R
M
R
A
G
R
T
A
A
E
Q
L
C
A
K
T
N
I
F
I
L
A
E
S
L
G
S
V
E
S
L
I
E
H
P
S
A
M
T
H
--
T
A
G
---
S
---
Q
---
L
E
---
V
P
D
D
L
V
R
L
S
V
G
I
E
D
V
A
D
L
L
D
D
L
K
Q
A
L
G
1
PsiBlast_PDB
95.63
86%
-98
- C1 -
3QHX
4
?
A:
[16-392]
-----------
A
G
L
A
T
R
A
I
H
S
G
Y
R
P
D
P
-
A
T
G
A
V
N
A
P
I
Y
A
S
S
T
F
A
Q
D
G
V
-------
G
G
L
-------
R
-----
G
G
Y
E
Y
A
R
T
G
N
P
T
R
T
A
L
E
A
A
L
A
A
V
E
D
A
A
F
G
R
A
F
S
S
G
M
A
A
A
D
C
A
L
R
A
M
L
R
P
G
D
H
V
V
I
P
D
D
A
Y
G
G
T
F
R
L
I
D
K
V
F
T
G
-
W
-
N
V
E
Y
T
P
V
A
L
--
A
-
D
L
D
A
V
R
A
A
I
R
P
T
T
R
L
I
W
V
E
T
P
T
N
P
L
L
S
I
A
D
I
A
G
I
A
-
Q
L
--
G
A
D
-
S
--
S
A
K
V
L
V
D
N
T
F
A
S
P
A
L
-
Q
Q
P
L
S
L
G
A
D
V
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
-
G
-
A
L
V
-
T
N
D
E
E
L
D
Q
------
S
F
--------------------------
A
F
--
L
--
Q
--
N
G
A
G
A
V
P
G
P
F
D
A
Y
L
T
M
R
G
L
K
T
L
V
L
R
M
Q
R
H
S
E
N
A
A
A
V
A
E
F
L
A
E
H
P
A
I
S
T
V
L
Y
P
G
L
P
S
H
P
G
H
A
V
A
A
R
Q
M
R
-
G
F
G
G
M
V
S
V
R
M
R
A
G
R
T
A
A
E
Q
L
C
A
K
T
N
I
F
I
L
A
E
S
L
G
S
V
E
S
L
I
E
H
P
S
A
M
T
H
A
S
T
A
G
---
S
---
Q
---
L
E
---
V
P
D
D
L
V
R
L
S
V
G
I
E
D
V
A
D
L
L
D
D
L
K
Q
A
L
G
23
PsiBlast_CBE
95.08
86%
-99
- C1 -
3QHX
2
?
D:
[16-392]
-----------
A
G
L
A
T
R
A
I
H
S
G
Y
R
P
D
P
-
A
T
G
A
V
N
A
P
I
Y
A
S
S
T
F
A
Q
D
G
V
-------
G
G
L
-------
R
-----
G
G
Y
E
Y
A
R
T
G
N
P
T
R
T
A
L
E
A
A
L
A
A
V
E
D
A
A
F
G
R
A
F
S
S
G
M
A
A
A
D
C
A
L
R
A
M
L
R
P
G
D
H
V
V
I
P
D
D
A
Y
G
G
T
F
R
L
I
D
K
V
F
T
G
-
W
-
N
V
E
Y
T
P
V
A
L
--
A
-
D
L
D
A
V
R
A
A
I
R
P
T
T
R
L
I
W
V
E
T
P
T
N
P
L
L
S
I
A
D
I
A
G
I
A
-
Q
L
--
G
A
D
-
S
--
S
A
K
V
L
V
D
N
T
F
A
S
P
A
L
-
Q
Q
P
L
S
L
G
A
D
V
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
-
G
-
A
L
V
-
T
N
D
E
E
L
D
Q
------
S
F
--------------------------
A
F
--
L
--
Q
--
N
G
A
G
A
V
P
G
P
F
D
A
Y
L
T
M
R
G
L
K
T
L
V
L
R
M
Q
R
H
S
E
N
A
A
A
V
A
E
F
L
A
E
H
P
A
I
S
T
V
L
Y
P
G
L
P
S
H
P
G
H
A
V
A
A
R
Q
M
R
-
G
F
G
G
M
V
S
V
R
M
R
A
G
R
T
A
A
E
Q
L
C
A
K
T
N
I
F
I
L
A
E
S
L
G
S
V
E
S
L
I
E
H
P
S
A
M
T
H
A
S
T
A
G
---
S
---
Q
---
L
E
---
V
P
D
D
L
V
R
L
S
V
G
I
E
D
V
A
D
L
L
D
D
L
K
Q
A
L
G
21
PsiBlast_CBE
94.67
86%
-105
- C1 -
3QI6
1
?
C:
[16-392]
-----------
A
G
L
A
T
R
A
I
H
S
G
Y
R
P
D
P
-
A
T
G
A
V
N
A
P
I
Y
A
S
S
T
F
A
Q
D
G
V
-------
G
G
L
-------
R
-----
G
G
Y
E
Y
A
R
T
G
N
P
T
R
T
A
L
E
A
A
L
A
A
V
E
D
A
A
F
G
R
A
F
S
S
G
M
A
A
A
D
C
A
L
R
A
M
L
R
P
G
D
H
V
V
I
P
D
D
A
Y
G
G
T
F
R
L
I
D
K
V
F
T
G
-
W
-
N
V
E
Y
T
P
V
A
L
--
A
-
D
L
D
A
V
R
A
A
I
R
P
T
T
R
L
I
W
V
E
T
P
T
N
P
L
L
S
I
A
D
I
A
G
I
A
-
Q
L
--
G
A
D
-
S
--
S
A
K
V
L
V
D
N
T
F
A
S
P
A
L
-
Q
Q
P
L
S
L
G
A
D
V
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
-
G
-
A
L
V
-
T
N
D
E
E
L
D
Q
------
S
F
--------------------------
A
F
--
L
--
Q
--
N
G
A
G
A
V
P
G
P
F
D
A
Y
L
T
M
R
G
L
K
T
L
V
L
R
M
Q
R
H
S
E
N
A
A
A
V
A
E
F
L
A
E
H
P
A
I
S
T
V
L
Y
P
G
L
P
S
H
P
G
H
A
V
A
A
R
Q
M
R
-
G
F
G
G
M
V
S
V
R
M
R
A
G
R
T
A
A
E
Q
L
C
A
K
T
N
I
F
I
L
A
E
S
L
G
S
V
E
S
L
I
E
H
P
S
A
M
-----------------------
V
P
D
D
L
V
R
L
S
V
G
I
E
D
V
A
D
L
L
D
D
L
K
Q
A
L
G
24
PsiBlast_CBE
94.45
86%
-101
- C1 -
3QHX
2
?
C:
[16-392]
-----------
A
G
L
A
T
R
A
I
H
S
G
Y
R
P
D
P
-
A
T
G
A
V
N
A
P
I
Y
A
S
S
T
F
A
Q
D
----------
G
L
-------
R
-----
G
G
Y
E
Y
A
R
T
G
N
P
T
R
T
A
L
E
A
A
L
A
A
V
E
D
A
A
F
G
R
A
F
S
S
G
M
A
A
A
D
C
A
L
R
A
M
L
R
P
G
D
H
V
V
I
P
D
D
A
Y
G
G
T
F
R
L
I
D
K
V
F
T
G
-
W
-
N
V
E
Y
T
P
V
A
L
--
A
-
D
L
D
A
V
R
A
A
I
R
P
T
T
R
L
I
W
V
E
T
P
T
N
P
L
L
S
I
A
D
I
A
G
I
A
-
Q
L
--
G
A
D
-
S
--
S
A
K
V
L
V
D
N
T
F
A
S
P
A
L
-
Q
Q
P
L
S
L
G
A
D
V
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
-
G
-
A
L
V
-
T
N
D
E
E
L
D
Q
------
S
F
--------------------------
A
F
--
L
--
Q
--
N
G
A
G
A
V
P
G
P
F
D
A
Y
L
T
M
R
G
L
K
T
L
V
L
R
M
Q
R
H
S
E
N
A
A
A
V
A
E
F
L
A
E
H
P
A
I
S
T
V
L
Y
P
G
L
P
S
H
P
G
H
A
V
A
A
R
Q
M
R
-
G
F
G
G
M
V
S
V
R
M
R
A
G
R
T
A
A
E
Q
L
C
A
K
T
N
I
F
I
L
A
E
S
L
G
S
V
E
S
L
I
E
H
P
S
A
M
T
-----
G
---
S
---
Q
---
L
E
---
V
P
D
D
L
V
R
L
S
V
G
I
E
D
V
A
D
L
L
D
D
L
K
Q
A
L
G
109
HHSearch
93.16
85%
-97
- C1 -
3QHX
4
?
A:
[16-392]
-----------
A
G
L
A
T
R
A
I
H
S
G
Y
R
P
D
P
-
A
T
G
A
V
N
A
P
I
Y
A
S
S
T
F
A
Q
D
G
V
-------
G
G
L
-------
R
-----
G
G
Y
E
Y
A
R
T
G
N
P
T
R
T
A
L
E
A
A
L
A
A
V
E
D
A
A
F
G
R
A
F
S
S
G
M
A
A
A
D
C
A
L
R
A
M
L
R
P
G
D
H
V
V
I
P
D
D
A
Y
G
G
T
F
R
L
I
D
K
V
F
---
T
-
G
W
N
V
E
Y
T
P
V
AL
A
-
D
L
D
A
V
R
A
A
I
R
P
T
T
R
L
I
W
V
E
T
P
T
N
P
L
L
S
I
A
D
I
A
G
I
A
-
Q
L
--
G
A
D
-
S
--
S
A
K
V
L
V
D
N
T
F
A
S
P
A
L
-
Q
Q
P
L
S
L
G
A
D
V
V
L
H
S
T
T
K
Y
I
G
G
H
S
D
V
V
G
-
G
-
A
L
V
-
T
N
D
E
E
L
D
Q
------
S
F
--------------------------
A
F
--
L
--
Q
--
N
G
A
G
A
V
P
G
P
F
D
A
Y
L
T
M
R
G
L
K
T
L
V
L
R
M
Q
R
H
S
E
N
A
A
A
V
A
E
F
L
A
E
H
P
A
I
S
T
V
L
Y
P
G
L
P
S
H
P
G
H
A
V
A
A
R
Q
M
R
-
G
F
G
G
M
V
S
V
R
M
R
A
G
R
T
A
A
E
Q
L
C
A
K
T
N
I
F
I
L
A
E
S
L
G
S
V
E
S
L
I
E
H
P
S
A
M
T
H
A
S
T
A
G
---
S
---
Q
---
L
E
---
V
P
D
D
L
V
R
L
S
V
G
I
E
D
V
A
D
L
L
D
D
L
K
Q
A
L
G
4
PsiBlast_PDB
81.96
56%
-93
- C1 -
4IYO
8
?
A:
[18-393]
--------------
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
-------
G
E
H
-------
Q
-----
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
-
T
A
G
L
D
F
S
F
V
D
L
--
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
-
V
I
--
A
R
K
-
H
--
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
-
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
-
G
F
G
G
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
---
A
R
R
E
Q
---
L
G
---
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-
3
PsiBlast_PDB
81.72
56%
-94
- C1 -
4IY7
8
?
A:
[18-393]
--------------
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
-------
G
E
H
-------
Q
-----
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
-
T
A
G
L
D
F
S
F
V
D
L
--
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
-
V
I
--
A
R
K
-
H
--
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
-
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
-
G
F
G
G
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
---
A
R
R
E
Q
---
L
G
---
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-
25
PsiBlast_CBE
81.56
56%
-93
- C1 -
4IY7
5
?
D:
[18-393]
--------------
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
-------
G
E
H
-------
Q
-----
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
-
T
A
G
L
D
F
S
F
V
D
L
--
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
-
V
I
--
A
R
K
-
H
--
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
-
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
-
G
F
G
G
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
---
A
RRE
Q
---
L
G
---
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-
26
PsiBlast_CBE
81.36
56%
-94
- C1 -
4IY7
4
?
C:
[18-393]
--------------
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
-------
G
E
H
-------
Q
-----
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
-
T
A
G
L
D
F
S
F
V
D
L
--
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
-
V
I
--
A
R
K
-
H
--
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
-
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
-
G
F
G
G
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
---
A
RRE
Q
---
L
G
---
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-
27
PsiBlast_CBE
81.07
56%
-92
- C1 -
4IY7
6
?
B:
[18-393]
--------------
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
-------
G
E
H
-------
Q
-----
G
-
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
-
T
A
G
L
D
F
S
F
V
D
L
--
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
-
V
I
--
A
R
K
-
H
--
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
-
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
-
G
F
G
G
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
---
A
RRE
Q
---
L
G
---
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
-
103
HHSearch
80.56
55%
-90
- C1 -
4IY7
8
?
A:
[14-394]
----------
A
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
-------
G
E
--------
H
-----
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
-
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
-
G
L
D
F
S
F
V
D
L
--
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
-
V
I
--
A
R
K
-
H
--
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
-
I
A
V
V
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
-
G
F
G
G
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
---
Q
---
L
G
---
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
11
PsiBlast_PDB
79.01
42%
-91
- C1 -
4OMA
6
?
A:
[2-393]
-
S
D
C
R
T
-----
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
-----
G
A
A
-------
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
S
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
-
G
I
--
A
H
Q
-
Q
--
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
-
I
I
V
-
G
K
Q
E
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
---
E
---
E
R
L
K
A
G
---
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-
113
HHSearch
78.90
42%
-96
- C1 -
2RFV
1
?
A:
[2-394]
------
S
D
C
R
T
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
-------
E
Q
G
AARF----------
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
R
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
-
G
I
--
A
H
Q
-
Q
--
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
-
D
V
I
G
G
-
I
I
V
-
G
K
-
Q
E
F
I
D
------
Q
A
--------------------------
R
F
VG
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
EER
L
---
K
---
A
G
---
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
13
PsiBlast_PDB
78.72
41%
-89
- C1 -
3JWA
6
?
A:
[2-393]
-
S
D
C
R
T
-----
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
EQ-----
G
A
A
-------
R
FALEE
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
S
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
-
G
I
--
A
H
Q
-
Q
--
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
-
I
I
V
-
G
K
Q
E
F
I
D
Q
A-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
---
E
---
E
RLK
A
G
---
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-
16
PsiBlast_PDB
78.63
41%
-92
- C1 -
2RFV
1
?
A:
[2-393]
-
S
D
C
R
T
-----
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
EQ-----
G
A
A
-------
R
F-----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
R
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
-
G
I
--
A
H
Q
-
Q
--
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
-
I
I
V
-
G
K
Q
E
F
I
D
Q
A-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
---
E
---
E
RLK
A
G
---
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-
102
HHSearch
78.59
47%
-94
- C1 -
3COG
5
CGL_HUMAN
A:
[13-396]
-------
L
P
H
F
Q
H
F
A
T
Q
A
I
H
V
G
Q
D
P
E
Q
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
----------------------------------
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
T
-
I
T
H
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
-
F
-
G
L
K
I
S
F
V
D
C
--
S
-
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
C
A
-
H
I
--
V
H
K
-
H
G
-
D
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
-
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
-
G
-
L
V
S
-
V
N
C
E
S
L
H
N
------
R
L
--------------------------
R
F
--
L
--
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
T
-
G
C
T
G
M
V
T
F
Y
I
K
G
T
L
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
---
V
---
L
G
---
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
5
PsiBlast_PDB
78.49
56%
-95
- C1 -
3E6G
-
?
A:
[18-392]
--------------
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
-------------------------------
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
T
V
M
E
-
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
-
T
A
G
L
D
F
S
F
V
D
L
--
T
-
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
I
A
-
V
I
--
A
R
K
-
H
--
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
-
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
G
H
S
D
M
V
G
-
G
I
A
V
V
-
G
D
N
A
E
L
A
E
------
Q
M
--------------------------
A
F
--
L
--
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
-
G
F
G
G
I
V
S
I
V
L
K
G
G
F
D
A
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
---
A
RRE
Q
---
L
G
---
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
--
14
PsiBlast_PDB
77.65
41%
-90
- C1 -
3JWB
4
?
A:
[2-393]
-
S
D
C
R
T
-----
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
EQ-----
G
A
A
-------
R
FALEE
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
S
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
-
G
I
--
A
H
Q
-
Q
--
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
-
I
I
V
-
G
K
Q
E
F
I
D
Q
A-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
---
E
---
E
RLK
A
G
---
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-
12
PsiBlast_PDB
77.54
42%
-90
- C1 -
4HF8
5
?
A:
[2-393]
-
S
D
C
R
T
-----
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
EQ-----
G
A
A
-------
R
FALEE
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
R
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
-
G
I
--
A
H
Q
-
Q
--
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
-
I
I
V
-
G
K
Q
E
F
I
D
Q
A-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
---
E
---
E
RLK
A
G
---
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-
15
PsiBlast_PDB
76.88
41%
-89
- C1 -
3JW9
2
?
A:
[2-393]
-
S
D
C
R
T
-----
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
-----
G
A
A
-------
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
S
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
-
G
I
--
A
H
Q
-
Q
--
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
-
I
I
V
-
G
K
Q
E
F
I
D
Q
A
-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
---
E
---
E
R
L
K
A
G
---
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-
43
PsiBlast_CBE
76.56
42%
-89
- C1 -
5DX5
4
?
B:
[8-395]
------------
G
F
A
T
K
A
I
H
G
G
H
I
G
D
K
-
Q
F
G
S
L
A
T
P
I
Y
Q
T
S
T
F
I
F
D
S
A
EQ-----
G
G
R
-------
R
FAGEE
S
G
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
I
A
A
S
L
W
S
A
L
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
N
H
G
L
T
R
-
Y
-
G
V
E
V
T
F
V
D
V
--
S
-
N
L
D
E
V
K
N
A
L
K
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
K
I
S
-
N
M
VH
E
S
N
-
K
--
E
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
-
Q
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
-
G
-
F
A
V
-
G
K
E
E
F
I
N
Q
------
V
K
--------------------------
L
F
G-
I
--
K
--
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
P
G
L
E
S
F
K
Y
Y
Q
L
A
R
E
Q
M
K
-
L
P
G
A
M
I
S
F
E
L
K
G
G
V
E
E
G
K
I
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
---
E
---
E
---
R
K
AAG
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
-
105
HHSearch
75.28
42%
-86
- C1 -
5DX5
3
?
A:
[2-396]
------
E
N
I
K
K
M
G
F
A
T
K
A
I
H
G
G
H
I
G
D
K
-
Q
F
G
S
L
A
T
P
I
Y
Q
T
S
T
F
I
F
D
S
A
-------
E
Q
G
G
R
R
F
A
GE
E
-----
S
G
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
I
A
A
S
L
W
S
A
L
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
N
H
G
L
T
R
-
Y
-
G
V
E
V
T
F
V
D
V
--
S
-
N
L
D
E
V
K
N
A
L
K
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
K
I
S
-
N
M
--
V
H
E
-
S
NK
E
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
-
Q
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
-
G
-
F
A
V
-
G
K
-
E
E
F
I
N
------
Q
V
--------------------------
K
L
--
F
--
G
IK
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
P
G
L
E
S
F
K
Y
Y
Q
L
A
R
E
Q
M
K
-
L
P
G
A
M
I
S
F
E
L
K
G
G
V
E
E
G
K
I
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
E
E
R
K
---
A
---
A
G
---
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
D
17
PsiBlast_PDB
74.99
42%
-89
- C1 -
5DX5
3
?
A:
[8-395]
------------
G
F
A
T
K
A
I
H
G
G
H
I
G
D
K
-
Q
F
G
S
L
A
T
P
I
Y
Q
T
S
T
F
I
F
D
S
A
E
Q
-----
G
G
R
-------
R
F
A
GE
E
S
G
Y
I
Y
S
R
L
G
N
P
T
S
T
E
V
E
N
K
L
A
L
L
E
G
G
E
A
A
V
V
A
A
S
G
M
G
A
I
A
A
S
L
W
S
A
L
K
S
G
D
H
V
V
A
S
D
T
L
Y
G
C
T
F
A
L
L
N
H
G
L
T
R
-
Y
-
G
V
E
V
T
F
V
D
V
--
S
-
N
L
D
E
V
K
N
A
L
K
P
N
T
K
V
V
Y
L
E
T
P
A
N
P
T
L
K
V
T
D
I
R
K
I
S
-
N
M
V
H
E
S
N
-
K
--
E
C
F
V
F
V
D
N
T
F
C
T
P
Y
I
-
Q
R
P
L
E
L
G
A
D
V
V
V
H
S
A
T
K
Y
L
N
G
H
G
D
V
I
A
-
G
-
F
A
V
-
G
K
E
E
F
I
N
Q
------
V
K
--------------------------
L
F
G-
I
--
K
--
D
M
T
G
S
V
T
G
P
F
E
S
F
L
I
I
R
G
M
K
T
L
Q
L
R
M
E
K
H
C
K
N
A
M
E
V
A
K
F
L
E
S
H
P
A
V
E
K
V
Y
Y
P
G
L
E
S
F
K
Y
Y
Q
L
A
R
E
Q
M
K
-
L
P
G
A
M
I
S
F
E
L
K
G
G
V
E
E
G
K
I
V
M
N
N
V
K
L
A
T
L
A
V
S
L
G
D
S
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
Y
T
A
---
E
---
E
---
R
K
A
A
G
I
S
D
G
L
V
R
L
S
V
G
L
E
D
A
E
D
I
I
D
D
L
K
Q
A
L
-
10
PsiBlast_PDB
74.65
42%
-91
- C1 -
3MKJ
1
?
A:
[2-393]
-
S
D
C
R
T
-----
Y
G
F
N
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
EQ-----
G
A
A
-------
R
F-----------
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
-
F
-
G
I
N
V
S
F
V
D
A
--
A
-
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
-
G
I
--
A
H
Q
-
Q
--
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
-
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
G
D
V
I
G
-
G
-
I
I
V
-
G
K
Q
E
F
I
D
Q
A-----
R
F
--------------------------
V
G
--
L
--
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
-
L
P
G
G
I
I
S
F
E
I
A
G
G
L
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
---
E
---
E
RLK
A
G
---
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
-
70
PsiBlast_CBE
74.27
39%
-91
- C1 -
1E5F
5
?
B:
[8-392]
-------------
P
A
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
QQGGNRF
A
G
Q
-------
E
-----
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
-
G
I
Q
V
D
F
I
N
T
--
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
--
H
S
Q
-
E
--
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
-
L
I
C
-
G
K
A
D
L
L
Q
Q
I-----
R
M
--------------------------
V
G
--
I
--
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
-
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
---
E
---
E
---
R
E
AAG
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
-
107
HHSearch
73.62
40%
-88
- C1 -
1E5E
5
?
A:
[4-393]
---------
E
R
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
-------
Q
Q
G
G
N
R
F
A
GQ
E
-----
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
-
G
I
Q
V
D
F
I
N
T
--
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
-
K
D
--
A
H
S
Q
E
--
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
-
L
I
C
-
G
K
-
A
D
L
L
Q
------
Q
I
--------------------------
R
M
--
V
GI
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
-
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
---
A
---
A
G
---
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
72
PsiBlast_CBE
73.59
39%
-91
- C1 -
1E5E
6
?
B:
[8-392]
-------------
P
A
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
QQGGNRF
A
G
Q
-------
E
-----
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
-
G
I
Q
V
D
F
I
N
T
--
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
--
H
S
Q
-
E
--
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
-
L
I
C
-
G
K
A
D
L
L
Q
Q
I-----
R
M
--------------------------
V
G
--
I
--
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
-
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
---
E
---
E
---
R
E
AAG
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
-
71
PsiBlast_CBE
72.41
39%
-90
- C1 -
1E5F
6
?
A:
[8-392]
-------------
P
A
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
-------
E
-----
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
-
G
I
Q
V
D
F
I
N
T
--
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
--
H
S
Q
-
E
--
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
-
L
I
C
-
G
K
A
D
L
L
Q
Q
I
-----
R
M
--------------------------
V
G
--
I
--
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
-
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
---
E
---
E
---
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
-
73
PsiBlast_CBE
72.27
39%
-89
- C1 -
1E5E
5
?
A:
[8-392]
-------------
P
A
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
-------
E
-----
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
-
F
-
G
I
Q
V
D
F
I
N
T
--
A
-
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
--
H
S
Q
-
E
--
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
-
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
-
L
I
C
-
G
K
A
D
L
L
Q
Q
I
-----
R
M
--------------------------
V
G
--
I
--
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
-
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
---
E
---
E
---
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
-
106
HHSearch
72.24
42%
-89
- C1 -
1IBJ
4
METC_ARATH
A:
[85-460]
-----------
A
S
V
S
T
L
L
V
N
L
D
N
K
F
D
--
P
F
D
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
-------
I
E
--------
N
-----
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
V
-
T
H
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
-
G
V
V
V
K
R
V
N
T
--
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
-
E
M
--
A
H
A
-
Q
--
G
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
-
V
L
A
-
V
K
G
E
K
L
A
K
------
E
V
--------------------------
Y
F
--
L
--
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
K
-
G
A
G
S
V
F
S
F
I
T
G
S
V
-
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
EVR
E
---
A
---
R
G
---
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
20
PsiBlast_PDB
69.61
43%
-92
- C1 -
1IBJ
4
METC_ARATH
A:
[103-459]
-------------------------------
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
-------
I
E
--------
N
-----
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
V
T
H
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
-
G
V
V
V
K
R
V
N
T
--
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
-
E
M
--
A
H
A
-
Q
--
G
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
-
V
L
A
-
V
K
G
E
K
L
A
K
------
E
V
--------------------------
Y
F
--
L
--
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
K
-
G
A
G
S
V
F
S
F
-
I
T
G
S
V
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
---
E
---
V
---
R
E
ARG
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
-
44
PsiBlast_CBE
67.27
43%
-88
- C1 -
1IBJ
3
METC_ARATH
C:
[103-459]
-------------------------------
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
-------
I
E
--------
N
-----
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
V
T
H
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
-
S
-
G
V
V
V
K
R
V
N
T
--
T
-
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
-
E
M
--
A
H
A
-
Q
--
G
A
L
V
L
V
D
N
S
I
M
S
P
V
L
-
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
-
V
L
A
-
V
K
G
E
K
L
A
K
------
E
V
--------------------------
Y
F
--
L
--
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
K
-
G
A
G
S
V
F
S
F
-
I
T
G
S
V
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
---
E
---
V
---
R
E
ARG
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
-
114
HHSearch
61.30
34%
-84
- C1 -
2CTZ
1
?
A:
[2-421]
------------
R
F
E
T
L
Q
L
H
A
G
Y
E
P
E
P
-
T
T
L
S
R
Q
V
P
I
Y
P
T
T
S
Y
V
F
K
S
P
-------
E
H
A
A
N
L
F
A
LK
E
-----
F
G
N
I
Y
S
R
I
M
N
P
T
V
D
V
L
E
K
R
L
A
A
L
E
G
G
K
A
A
L
A
T
A
S
G
H
A
A
Q
F
L
A
L
T
T
L
A
Q
A
G
D
N
I
V
S
T
P
N
L
Y
G
G
T
F
N
Q
F
K
V
T
L
K
R
-
L
-
G
I
E
V
R
F
T
S
R
--
E
E
R
P
E
E
F
L
A
L
T
D
E
K
T
R
A
W
W
V
E
S
I
G
N
P
A
L
N
I
P
D
L
E
A
L
A
-
Q
A
--
A
R
E
-
K
--
G
V
A
L
I
V
D
N
T
F
G
M
G
G
Y
L
L
R
P
L
A
W
G
A
A
L
V
T
H
S
L
T
K
W
V
G
G
H
G
A
V
I
A
-
G
-
A
I
V
-
D
G
-
G
N
F
P
W
EGGRYP
L
L
TEPQPGYHGLRLTEAFGEL
A
F
I
V
K
A
R
V
D
--
G
--
L
--
R
D
Q
G
Q
A
L
G
P
F
E
A
W
V
V
L
L
G
M
E
T
L
S
L
R
A
E
R
H
V
E
N
T
L
H
L
A
H
W
L
L
E
Q
P
Q
V
A
W
V
N
Y
P
G
L
P
H
H
P
H
H
D
R
A
Q
K
Y
F
K
G
K
P
G
A
V
L
T
F
G
L
K
G
G
Y
E
A
A
K
R
F
I
S
R
L
K
L
I
S
H
L
A
N
V
G
D
T
R
T
L
A
I
H
P
A
S
T
T
H
S
Q
L
S
P
E
E
Q
A
---
Q
---
A
G
---
V
S
P
E
M
V
R
L
S
V
G
L
E
H
V
E
D
L
K
A
E
L
K
E
A
L
A