@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1093: (2016-04-28 )
MSAPLAEVDPDIAELLAKELGRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEHVDVVENLARDRAKALFGAEFANVQPHSGAQANAAVLHALMSPGERLLGLDLANGGHLTHGMRLNFSGKLYENGFYGVDPATHLIDMDAVRATALEFRPKVIIAGWSAYPRVLDFAAFRSIADEVGAKLLVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGGRSGLIVGKQQYAKAINSAVFPGQQGGPLMHVIAGKAVALKIAATPEFADRQRRTLSGARIIADRLMAPDVAKAGVSVVSGGTDVHLVLVDLRDSPLDGQAAEDLLHEVGITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFGDTEFTEVADIIATALATGSSVDVSALKDRATRLARAFPLYDGLEEWSLVGR
Atome Classification :
(70 SA)
-----------.........10........20........30........40........50........60........70........80.....----..----.90........100.......110.......120......-----.-------130.......140.......150.......160.......170.......-180.......190.......200.......210.......220.......230.....------------.---.240---------------.--------.......250.......260.....-..270.......280.......290.....-..300.......310.......320....-...330.......340.......350.......360.......370...----....380...----....390.-.----------------------..-------------------------.-.--------.-.400........410.......420....--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MSAPLAEVD
P
D
I
A
E
L
L
A
K
E
LGRQ
R
D
T
L
E
M
I
A
SENF
V
P
R
A
V
L
Q
AQG
S
V
L
T
N
K
Y
AEGLPGRRYYGGC
E
H
V
D
V
V
E
N
L
A
R
D
R
A
K
A
L
FGAE----FA----NVQPHSGA
Q
A
N
A
A
V
L
H
A
L
MSPG
E
R
L
L
G
L
D
LANGGHLTH
G
M
-----
R
-------LNFS
G
K
L
YENGFYGVDP
A
T
H
L
I
D
M
D
A
V
R
A
T
A
L
EFRP
K
V
I
I
AGWSA
Y
P
R
V
L
-
D
F
A
A
F
R
S
I
A
D
E
V
G
A
K
L
L
V
D
M
A
H
F
A
G
L
V
A
AGLHPSPVP
H
A
D
V
V
S
T
T
V
H
K
TLGGGR
S
G
L
I
------------V---
G
K
-
Q
---------------
Q
--------
Y
A
K
A
I
N
S
AVFPGQQGG
P
L
M
H
V
IAG
K
-
A
V
A
L
K
I
AATP
E
F
A
D
R
Q
R
RTLS
G
A
R
I
I
A
D
R
L-MA
P
D
V
A
K
AG
V
S
V
VSGG
T
D
V
H
L
V
L
V
DLRDS-PLD
G
Q
A
A
E
D
L
L
H
EVG
I
T
V
NRNAVPNDPRPPMVTSGLRIGT
P
A
L
ATRGFG----D
T
E
F
T
E
V
A
D
I
----
I
A
T
A
L-AT-G----------------------SS-------------------------V-
D
--------
V
-
S
A
-
L
K
D
R
A
T
R
L
A
R
AFPLYD
G
L
E
E
W
SLVGR--------------
26
PsiBlast_CBE
81.61
58%
-89
- C1 -
2VMY
7
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
48
PsiBlast_CBE
81.29
54%
-93
- C1 -
3PGY
4
GLYA_STAAC
A:
[7-414]
---------------
I
T
K
Q
D
K
V
I
A
E
A
I
E
R
E
F
Q
R
Q
N
S
N
I
E
L
I
A
S
E
N
F
V
S
E
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
--
G
G
C
E
F
V
D
V
T
E
S
I
A
I
D
R
A
K
A
L
F
G
A
E
----
H
V
----
N
V
Q
P
H
S
G
P
Q
A
N
M
A
V
Y
L
V
A
L
E
M
G
D
T
V
L
G
M
N
L
S
H
-------------
P
-------
V
N
F
S
G
K
F
Y
N
F
V
E
Y
G
V
D
K
D
T
E
R
I
N
Y
D
E
V
R
K
L
A
L
E
H
K
P
K
L
I
V
A
G
A
S
A
Y
S
R
T
I
-
D
F
K
K
F
K
E
I
A
D
E
V
N
A
K
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
E
Y
A
D
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
K
-
E
---------------
E
--------
Y
K
K
D
I
D
K
T
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
E
N
N
F
K
T
Y
Q
Q
Q
V
V
K
N
A
K
V
L
A
E
A
L
-
I
-----
N
E
G
F
R
I
V
S
G
G
T
D
N
H
L
V
A
V
D
V
K
G
S
I
G
L
T
G
K
E
A
E
E
T
L
D
S
V
G
I
T
C
N
K
N
T
I
P
F
D
Q
E
K
P
F
V
T
S
G
I
R
L
G
T
P
A
A
T
T
R
G
F
D
----
E
K
A
F
E
E
V
A
K
I
----
I
S
L
A
L
-
K
N
-
S
----------------------
K
D
-------------------------
E
-
E
K
-------
L
-
Q
Q
-
A
K
E
R
V
A
K
L
T
A
E
Y
P
L
Y
-------------------------
17
PsiBlast_PDB
81.25
57%
-90
- C1 -
2W7D
3
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
24
PsiBlast_CBE
80.95
58%
-89
- C1 -
2VMZ
3
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
9
PsiBlast_PDB
80.75
57%
-89
- C1 -
2VIB
5
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
8
PsiBlast_PDB
80.73
57%
-90
- C1 -
2VI8
4
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
29
PsiBlast_CBE
80.71
58%
-89
- C1 -
2VMV
2
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
12
PsiBlast_PDB
80.66
57%
-89
- C1 -
2VGS
2
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
16
PsiBlast_PDB
80.57
57%
-88
- C1 -
2VGU
4
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
27
PsiBlast_CBE
80.52
58%
-89
- C1 -
2VMX
3
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
42
PsiBlast_CBE
80.49
57%
-89
- C1 -
2VMT
4
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
43
PsiBlast_CBE
80.47
57%
-87
- C1 -
2VMS
4
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
18
PsiBlast_PDB
80.44
57%
-88
- C1 -
2W7E
4
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
44
PsiBlast_CBE
80.42
57%
-89
- C1 -
2VMR
3
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
2
PsiBlast_PDB
80.38
60%
-88
- C1 -
2DKJ
4
GLYA_THET8
A:
[8-406]
-------------------
D
E
A
L
F
E
L
I
A
L
E
E
K
R
Q
R
E
G
L
E
L
I
A
S
E
N
F
V
S
K
Q
V
R
E
A
V
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
A
R
Y
Y
G
G
C
E
V
I
D
R
V
E
S
L
A
I
E
R
A
K
A
L
F
G
A
A
----
W
A
----
N
V
Q
P
H
S
G
S
Q
A
N
M
A
V
Y
M
A
L
M
E
P
G
D
T
L
M
G
M
D
L
A
A
G
G
H
L
T
H
G
S
-----
R
-------
V
N
F
S
G
K
L
Y
K
V
V
S
Y
G
V
R
P
D
T
E
L
I
D
L
E
E
V
R
R
L
A
L
E
H
R
P
K
V
I
V
A
G
A
S
A
Y
P
R
F
W
-
D
F
K
A
F
R
E
I
A
D
E
V
G
A
Y
L
V
V
D
M
A
H
F
A
G
L
V
A
A
G
L
H
P
N
P
L
P
Y
A
H
V
V
T
S
T
T
H
K
T
L
R
G
P
R
G
G
L
I
------------
L
---
S
N
-
D
P
--------------
E
--------
L
G
K
R
I
D
K
L
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
G
K
-
A
V
A
F
F
E
A
L
Q
P
E
F
K
E
Y
S
R
L
V
V
E
N
A
K
R
L
A
E
E
L
------
A
R
R
G
Y
R
I
V
T
G
G
T
D
N
H
L
F
L
V
D
L
R
P
K
-
G
L
T
G
K
E
A
E
E
R
L
D
A
V
G
I
T
V
N
K
N
A
I
P
F
D
P
K
P
P
R
V
T
S
G
I
R
I
G
T
P
A
I
T
T
R
G
F
T
----
P
E
E
M
P
L
V
A
E
L
----
I
D
R
A
L
-
L
E
-
G
----------------------
P
S
--------------------------------------
E
A
-
L
R
E
E
V
R
R
L
A
L
A
H
P
M
--------------------------
46
PsiBlast_CBE
80.31
54%
-96
- C1 -
3PGY
5
GLYA_STAAC
C:
[7-414]
---------------
I
T
K
Q
D
K
V
I
A
E
A
I
E
R
E
F
Q
R
Q
N
S
N
I
E
L
I
A
S
E
N
F
V
S
E
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
--
G
G
C
E
F
V
D
V
T
E
S
I
A
I
D
R
A
K
A
L
F
G
A
E
----
H
V
----
N
V
Q
P
H
S
G
P
Q
A
N
M
A
V
Y
L
V
A
L
E
M
G
D
T
V
L
G
M
N
------------------------
V
N
F
S
G
K
F
Y
N
F
V
E
Y
G
V
D
K
D
T
E
R
I
N
Y
D
E
V
R
K
L
A
L
E
H
K
P
K
L
I
V
A
G
A
S
A
Y
S
R
T
I
-
D
F
K
K
F
K
E
I
A
D
E
V
N
A
K
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
E
Y
A
D
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
K
-
E
---------------
E
--------
Y
K
K
D
I
D
K
T
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
E
N
N
F
K
T
Y
Q
Q
Q
V
V
K
N
A
K
V
L
A
E
A
L
-
I
-----
N
E
G
F
R
I
V
S
G
G
T
D
N
H
L
V
A
V
D
V
K
G
S
I
G
L
T
G
K
E
A
E
E
T
L
D
S
V
G
I
T
C
N
K
N
T
I
P
F
D
Q
E
K
P
F
V
T
S
G
I
R
L
G
T
P
A
A
T
T
R
G
F
D
----
E
K
A
F
E
E
V
A
K
I
----
I
S
L
A
L
-
K
N
-
S
----------------------
K
D
-------------------------
E
-
E
K
-------
L
-
Q
Q
-
A
K
E
R
V
A
K
L
T
A
E
Y
P
L
Y
-------------------------
33
PsiBlast_CBE
80.29
57%
-88
- C1 -
2VMP
5
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
25
PsiBlast_CBE
80.29
58%
-88
- C1 -
2VMY
7
?
B:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
59
PsiBlast_CBE
80.25
52%
-91
- C1 -
4OT8
4
?
D:
[17-422]
---------------
I
A
N
V
D
P
E
I
F
A
A
I
E
Q
E
N
R
R
Q
E
D
H
I
E
L
I
A
S
E
N
Y
T
S
P
A
V
M
A
A
Q
G
S
Q
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
V
V
E
Q
L
A
I
D
R
V
K
Q
L
F
G
A
E
----
A
A
----
N
V
Q
P
N
S
G
S
Q
A
N
Q
G
V
F
F
A
M
L
K
P
G
D
T
I
M
G
M
S
L
A
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
M
S
G
K
W
F
N
V
V
S
Y
G
L
N
-
E
N
E
D
I
D
Y
D
A
A
E
K
L
A
N
E
H
K
P
K
L
I
V
A
G
A
S
A
F
A
L
K
I
-
D
F
E
R
L
A
K
I
A
K
S
V
G
A
Y
L
M
V
D
M
A
H
Y
A
G
L
I
A
A
G
V
Y
P
N
P
V
P
H
A
D
F
V
T
T
T
T
H
K
S
L
R
G
P
R
G
G
V
I
------------
L
---
M
K
-
A
---------------
E
--------
Y
E
K
P
I
N
S
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
K
E
A
L
S
P
E
F
K
E
Y
Q
Q
K
V
V
E
N
A
R
V
L
A
E
T
L
-
V
-----
K
R
G
L
R
I
V
S
G
R
T
E
S
H
V
M
L
V
D
L
R
A
K
-
H
I
T
G
K
A
A
E
A
A
L
G
A
A
H
I
T
V
N
K
N
A
I
P
N
D
P
E
K
P
F
V
T
S
G
I
R
L
G
S
P
A
M
T
T
R
G
F
G
----
P
A
E
A
E
Q
V
G
N
L
----
I
A
D
V
L
-
E
N
P
E
----------------------
D
A
-------------------------
A
-
T
--------
I
-
E
R
-
V
R
A
Q
V
A
E
L
T
K
R
F
P
V
Y
-------------------------
47
PsiBlast_CBE
80.23
54%
-94
- C1 -
3PGY
6
GLYA_STAAC
B:
[7-414]
---------------
I
T
K
Q
D
K
V
I
A
E
A
I
E
R
E
F
Q
R
Q
N
S
N
I
E
L
I
A
S
E
N
F
V
S
E
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
F
V
D
V
T
E
S
I
A
I
D
R
A
K
A
L
F
G
A
E
----
H
V
----
N
V
Q
P
H
S
G
P
Q
A
N
M
A
V
Y
L
V
A
L
E
M
G
D
T
V
L
G
M
N
L
S
H
-------
A
-----
P
-------
V
N
F
S
G
K
F
Y
N
F
V
E
Y
G
V
D
K
D
T
E
R
I
N
Y
D
E
V
R
K
L
A
L
E
H
K
P
K
L
I
V
A
G
A
S
A
Y
S
R
T
I
-
D
F
K
K
F
K
E
I
A
D
E
V
N
A
K
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
E
Y
A
D
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
K
-
E
---------------
E
--------
Y
K
K
D
I
D
K
T
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
E
N
N
F
K
T
Y
Q
Q
Q
V
V
K
N
A
K
V
L
A
E
A
L
-
I
-----
N
E
G
F
R
I
V
S
G
G
T
D
N
H
L
V
A
V
D
V
K
G
S
I
G
L
T
G
K
E
A
E
E
T
L
D
S
V
G
I
T
C
N
K
N
T
I
P
F
D
Q
E
K
P
F
V
T
S
G
I
R
L
G
T
P
A
A
T
T
R
G
F
D
----
E
K
A
F
E
E
V
A
K
I
----
I
S
L
A
L
-
K
N
-
S
----------------------
K
D
-------------------------
E
-
E
K
-------
L
-
Q
Q
-
A
K
E
R
V
A
K
L
T
A
E
Y
P
L
Y
-------------------------
41
PsiBlast_CBE
80.20
57%
-87
- C1 -
2VMU
4
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
A
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
19
PsiBlast_PDB
80.17
57%
-88
- C1 -
2W7F
5
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
13
PsiBlast_PDB
80.06
57%
-89
- C1 -
2VGT
4
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
32
PsiBlast_CBE
80.05
57%
-87
- C1 -
2VMQ
6
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
6
PsiBlast_PDB
79.99
57%
-90
- C1 -
1KL2
6
?
A:
[4-405]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
-------------------------
E
-
Q
A
L
E
E
A
R
Q
R
V
-
A
A
-
L
T
D
-------------------------------------
10
PsiBlast_PDB
79.98
57%
-89
- C1 -
2VIA
5
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
23
PsiBlast_CBE
79.94
57%
-89
- C1 -
2W7H
4
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
28
PsiBlast_CBE
79.84
58%
-88
- C1 -
2VMW
5
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
G
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
34
PsiBlast_CBE
79.78
57%
-87
- C1 -
2VMO
5
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
75
PsiBlast_CBE
79.72
52%
-91
- C1 -
4WXG
3
GLYA_STRT1
C:
[24-428]
-------------------
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
A
-----
P
-------
V
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
-
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
------------
L
T--
D
D
-
E
---------------
D
--------
I
A
K
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
-
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
-----
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
-
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
----
E
A
E
S
R
Q
I
A
E
W
----
M
V
E
A
L
-
E
N
-
H
----------------------
D
K
-------------------------
P
-
E
--------
V
L
E
R
-
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
-------------------------
35
PsiBlast_CBE
79.68
57%
-88
- C1 -
2VMN
4
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
A
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
21
PsiBlast_CBE
79.66
60%
-88
- C1 -
2DKJ
4
GLYA_THET8
B:
[8-406]
-------------------
D
E
A
L
F
E
L
I
A
L
E
E
K
R
Q
R
E
G
L
E
L
I
A
S
E
N
F
V
S
K
Q
V
R
E
A
V
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
A
R
Y
Y
G
G
C
E
V
I
D
R
V
E
S
L
A
I
E
R
A
K
A
L
F
G
A
A
----
W
A
----
N
V
Q
P
H
S
G
S
Q
A
N
M
A
V
Y
M
A
L
M
E
P
G
D
T
L
M
G
M
D
L
A
A
G
G
H
L
T
H
G
S
-----
R
-------
V
N
F
S
G
K
L
Y
K
V
V
S
Y
G
V
R
P
D
T
E
L
I
D
L
E
E
V
R
R
L
A
L
E
H
R
P
K
V
I
V
A
G
A
S
A
Y
P
R
F
W
-
D
F
K
A
F
R
E
I
A
D
E
V
G
A
Y
L
V
V
D
M
A
H
F
A
G
L
V
A
A
G
L
H
P
N
P
L
P
Y
A
H
V
V
T
S
T
T
H
K
T
L
R
G
P
R
G
G
L
I
------------
L
---
S
N
-
D
P--------------
E
--------
L
G
K
R
I
D
K
L
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
G
K
-
A
V
A
F
F
E
A
L
Q
P
E
F
K
E
Y
S
R
L
V
V
E
N
A
K
R
L
A
E
E
L
------
A
R
R
G
Y
R
I
V
T
G
G
T
D
N
H
L
F
L
V
D
L
R
P
K
-
G
L
T
G
K
E
A
E
E
R
L
D
A
V
G
I
T
V
N
K
N
A
I
P
F
D
P
K
P
P
R
V
T
S
G
I
R
I
G
T
P
A
I
T
T
R
G
F
T
----
P
E
E
M
P
L
V
A
E
L
----
I
D
R
A
L
-
L
E
-
G
----------------------
P
S
--------------------------------------
E
A
-
L
R
E
E
V
R
R
L
A
L
A
H
P
M
--------------------------
15
PsiBlast_PDB
79.64
57%
-87
- C1 -
2VGW
4
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
14
PsiBlast_PDB
79.58
57%
-89
- C1 -
2VGV
3
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
Q
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
7
PsiBlast_PDB
79.32
57%
-89
- C1 -
1YJS
1
?
A:
[4-405]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
Q
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
-------------------------
E
-
Q
A
L
E
E
A
R
Q
R
V
-
A
A
-
L
T
D
-------------------------------------
36
PsiBlast_CBE
79.31
57%
-89
- C1 -
2W7M
2
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
11
PsiBlast_PDB
79.23
57%
-87
- C1 -
2VI9
5
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
117
HHSearch
79.08
59%
-88
- C1 -
2DKJ
4
GLYA_THET8
A:
[6-407]
-----------------
K
R
D
E
A
L
F
E
L
I
A
L
E
E
K
R
Q
R
E
G
L
E
L
I
A
S
E
N
F
V
S
K
Q
V
R
E
A
V
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
A
R
Y
Y
G
G
C
E
V
I
D
R
V
E
S
L
A
I
E
R
A
K
A
L
F
G
A
A
----
W
A
----
N
V
Q
P
H
S
G
S
Q
A
N
M
A
V
Y
M
A
L
M
E
P
G
D
T
L
M
G
M
D
L
A
A
G
G
H
L
T
H
G
S
-----
R
-------
V
N
F
S
G
K
L
Y
K
V
V
S
Y
G
V
R
P
D
T
E
L
I
D
L
E
E
V
R
R
L
A
L
E
H
R
P
K
V
I
V
A
G
-
A
S
A
Y
P
R
F
W
D
F
K
A
F
R
E
I
A
D
E
V
G
A
Y
L
V
V
D
M
A
H
F
A
G
L
V
A
A
G
L
H
P
N
P
L
P
Y
A
H
V
V
T
S
T
T
H
K
T
L
R
G
P
R
G
G
L
I
------------
L
---
S
N
D
P
---------------
E
--------
L
G
K
R
I
D
K
L
I
F
P
G
I
Q
G
G
P
L
E
H
V
I
A
G
K
A
V
A
F
F
E
A
L
Q
-
P
E
F
K
E
Y
S
R
L
V
V
E
N
A
K
R
L
A
E
E
L
-
A
---
R
--
R
G
Y
R
I
V
T
G
G
T
D
N
H
L
F
L
V
D
L
R
P
K
-
G
L
T
G
K
E
A
E
E
R
L
D
A
V
G
I
T
V
N
K
N
A
I
P
F
D
P
K
P
P
R
V
T
S
G
I
R
I
G
T
P
A
I
T
T
R
G
F
T
----
P
E
E
M
P
L
V
A
E
L
----
I
D
R
A
L
-
L
E
-
G
----------------------
P
S
--------------------------------------
E
A
-
L
R
E
E
V
R
R
L
A
L
A
H
P
M
P
-------------------------
20
PsiBlast_PDB
79.08
57%
-88
- C1 -
2W7G
4
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
F
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
39
PsiBlast_CBE
79.05
57%
-88
- C1 -
2W7J
2
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
38
PsiBlast_CBE
78.97
57%
-88
- C1 -
2W7K
2
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
40
PsiBlast_CBE
78.90
57%
-88
- C1 -
2W7I
1
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
77
PsiBlast_CBE
78.86
52%
-88
- C1 -
4WXF
2
GLYA_STRT1
C:
[24-428]
-------------------
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
A
-----
P
-------
V
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
-
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
------------
L
T--
D
D
-
E
---------------
D
--------
I
A
K
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
-
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
-----
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
-
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
----
E
A
E
S
R
Q
I
A
E
W
----
M
V
E
A
L
-
E
N
-
H
----------------------
D
K
-------------------------
P
-
E
--------
V
L
E
R
-
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
-------------------------
37
PsiBlast_CBE
78.84
57%
-88
- C1 -
2W7L
2
?
A:
[4-401]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
A
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
------------------------------------
E
-
Q
A
-
L
E
E
A
R
Q
R
V
A
-------------------------------
76
PsiBlast_CBE
78.36
52%
-89
- C1 -
4WXG
4
GLYA_STRT1
A:
[24-428]
-------------------
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
A
-----
P
-------
V
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
-
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
------------
L
T
--
D
D
-
E
---------------
D
--------
I
A
K
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
-
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
-----
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
-
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
----
E
A
E
S
R
Q
I
A
E
W
----
M
V
E
A
L
-
E
N
-
H
----------------------
D
K
-------------------------
P
-
E
--------
V
L
E
R
-
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
-------------------------
4
PsiBlast_PDB
78.33
57%
-88
- C1 -
1KKP
2
?
A:
[4-405]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
-------------------------
E
-
Q
A
L
E
E
A
R
Q
R
V
-
A
A
-
L
T
D
-------------------------------------
30
PsiBlast_CBE
78.30
57%
-91
- C1 -
1YJZ
1
?
A:
[4-405]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
M
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
-------------------------
E
-
Q
A
L
E
E
A
R
Q
R
V
-
A
A
-
L
T
D
-------------------------------------
3
PsiBlast_PDB
78.27
57%
-90
- C1 -
1KKJ
1
?
A:
[4-405]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
-------------------------
E
-
Q
A
L
E
E
A
R
Q
R
V
-
A
A
-
L
T
D
-------------------------------------
115
HHSearch
78.10
52%
-89
- C1 -
4WXG
4
GLYA_STRT1
A:
[19-428]
--------------
D
Y
K
A
F
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
A
-----
P
-------
V
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
-
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
------------
L
---
T
D
D
E
---------------
D
--------
I
A
K
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
-
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
-
N
---
Q
H
-
P
D
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
-
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
----
E
A
E
S
R
Q
I
A
E
W
----
M
V
E
A
L
-
E
N
-
H
----------------------
D
K
-------------------------
P
E
V
--------
L
-
E
R
-
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
-------------------------
5
PsiBlast_PDB
78.08
57%
-89
- C1 -
1KL1
2
?
A:
[4-405]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
-------------------------
E
-
Q
A
L
E
E
A
R
Q
R
V
-
A
A
-
L
T
D
-------------------------------------
31
PsiBlast_CBE
78.04
57%
-91
- C1 -
1YJY
1
?
A:
[4-405]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
M
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
-------------------------
E
-
Q
A
L
E
E
A
R
Q
R
V
-
A
A
-
L
T
D
-------------------------------------
78
PsiBlast_CBE
78.01
52%
-89
- C1 -
4WXF
4
GLYA_STRT1
A:
[24-428]
-------------------
D
P
E
L
W
N
A
I
D
A
E
A
E
R
Q
Q
N
N
I
E
L
I
A
S
E
N
V
V
S
K
A
V
M
A
A
Q
G
T
L
L
T
N
K
Y
A
E
G
Y
P
G
K
R
Y
Y
G
G
T
A
V
I
D
V
V
E
T
L
A
I
E
R
A
K
K
L
F
G
A
K
----
F
A
----
N
V
Q
P
H
S
G
S
Q
A
N
A
A
V
Y
M
S
L
I
Q
P
G
D
T
V
M
G
M
D
L
S
A
G
G
H
L
T
H
G
A
-----
P
-------
V
S
F
S
G
K
T
Y
N
F
V
S
Y
N
V
D
K
E
S
E
L
L
D
Y
D
A
I
L
A
Q
A
K
E
V
R
P
K
L
I
V
A
G
A
S
A
Y
S
R
I
I
-
D
F
A
K
F
R
E
I
A
D
A
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
S
G
H
H
P
S
P
V
P
Y
A
H
V
T
T
T
T
T
H
K
T
L
R
G
P
R
G
G
L
I
------------
L
T
--
D
D
-
E
---------------
D
--------
I
A
K
K
L
N
S
A
V
F
P
G
L
Q
G
G
P
L
E
H
V
I
A
A
K
-
A
V
A
L
K
E
A
L
D
P
A
F
K
E
Y
G
E
N
V
I
K
N
A
A
A
M
A
D
V
F
N
Q
H
P
D
-----
F
R
V
I
S
G
G
T
N
N
H
L
F
L
V
D
V
T
K
V
-
V
E
N
G
K
V
A
Q
N
V
L
E
E
V
N
I
T
L
N
K
N
S
I
P
Y
E
Q
L
S
P
F
K
T
S
G
I
R
V
G
S
P
A
I
T
S
R
G
M
G
----
E
A
E
S
R
Q
I
A
E
W
----
M
V
E
A
L
-
E
N
-
H
----------------------
D
K
-------------------------
P
-
E
--------
V
L
E
R
-
I
R
G
D
V
K
V
L
T
D
A
F
P
L
Y
-------------------------
22
PsiBlast_CBE
77.94
57%
-88
- C1 -
1KL2
6
?
B:
[4-405]
---------------
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
S
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
-----
N
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
V
T
T
R
G
F
G
----
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
-------------------------
E
-
Q
ALEEARQR
V
-
A
A
-
L
T
D
-------------------------------------
119
HHSearch
77.15
58%
-89
* C1 *
2VI8
4
?
A:
[1-389]
------------
M
K
Y
L
P
Q
Q
D
P
Q
V
F
A
A
I
E
Q
E
R
K
R
Q
H
A
K
I
E
L
I
A
S
E
N
F
V
S
R
A
V
M
E
A
Q
G
S
V
L
T
N
K
Y
A
E
G
Y
P
G
R
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
E
L
A
R
E
R
A
K
Q
L
F
G
A
E
----
H
A
----
N
V
Q
P
H
S
G
A
Q
A
N
M
A
V
Y
F
T
V
L
E
H
G
D
T
V
L
G
M
N
L
S
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
V
Q
Y
N
F
V
A
Y
G
V
D
P
E
T
H
V
I
D
Y
D
D
V
R
E
K
A
R
L
H
R
P
K
L
I
V
A
A
A
A
A
Y
P
R
I
I
-
D
F
A
K
F
R
E
I
A
D
E
V
G
A
Y
L
M
V
D
M
A
H
I
A
G
L
V
A
A
G
L
H
P
N
P
V
P
Y
A
H
F
V
T
T
T
T
H
K
T
L
R
G
P
R
G
G
M
I
------------
L
---
C
Q
-
E
---------------
Q
--------
F
A
K
Q
I
D
K
A
I
F
P
G
I
Q
G
G
P
L
M
H
V
I
A
A
K
-
A
V
A
F
G
E
A
L
Q
D
D
F
K
A
Y
A
K
R
V
V
D
N
A
K
R
L
A
S
A
L
-
Q
---
N
--
E
G
F
T
L
V
S
G
G
T
D
N
H
L
L
L
V
D
L
R
P
Q
-
Q
L
T
G
K
T
A
E
K
V
L
D
E
V
G
I
T
V
N
K
N
T
I
P
Y
D
P
E
S
P
F
V
T
S
G
I
R
I
G
T
A
A
----
V
T
T
R
GFG
L
E
E
M
D
E
I
A
A
I
----
I
G
L
V
L
-
K
N
-
V
----------------------
G
S
---------------------------------------------------------------------------------
83
PsiBlast_CBE
76.26
45%
-92
- C1 -
4PVF
2
GLYM_HUMAN
B:
[28-477]
---------------
L
S
D
S
D
P
E
M
W
E
L
L
Q
R
E
K
D
R
Q
C
R
G
L
E
L
I
A
S
E
N
F
C
S
R
A
A
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
K
R
Y
Y
G
G
A
E
V
V
D
E
I
E
L
L
C
Q
R
R
A
L
E
A
F
D
L
D
----
P
A
QWGV
N
V
Q
P
Y
S
G
S
P
A
N
L
A
V
Y
T
A
L
L
Q
P
H
D
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
Y
MSDVK
R
-------
I
S
A
T
S
I
F
F
E
S
M
P
Y
K
L
N
P
K
T
G
L
I
D
Y
N
Q
L
A
L
T
A
R
L
F
R
P
R
L
I
I
A
G
T
S
A
Y
A
R
L
I
-
D
Y
A
R
M
R
E
V
C
D
E
V
K
A
H
L
L
A
D
M
A
H
I
S
G
L
V
A
A
K
V
I
P
S
P
F
K
H
A
D
I
V
T
T
T
T
H
K
T
L
R
G
A
R
S
G
L
I
------------
F
---
Y
R
-
K
GVKAIPY--------
T
--------
F
E
D
R
I
N
F
A
V
F
P
S
L
Q
G
G
P
H
N
H
A
I
A
A
V
-
A
V
A
L
K
Q
A
C
T
P
M
F
R
E
Y
S
L
Q
V
L
K
N
A
R
A
M
A
D
A
L
-
L
-----
E
R
G
Y
S
L
V
S
G
G
T
D
N
H
L
V
L
V
D
L
R
P
K
-
G
L
D
G
A
R
A
E
R
V
L
E
L
V
S
I
T
A
N
K
N
T
C
--------
T
P
G
G
L
R
L
G
A
P
A
L
T
S
R
Q
F
R
----
E
D
D
F
R
R
V
V
D
F
----
I
D
E
G
V
-
N
I
-
G
LEVKSKTAKLQDFKSFLLKDSE
T
S
-------------------------
Q
-
R
--------
L
-
A
N
-
L
R
Q
R
V
E
Q
F
A
R
A
F
P
M
--------------------------
84
PsiBlast_CBE
76.01
45%
-88
- C1 -
4PVF
3
GLYM_HUMAN
A:
[28-477]
---------------
L
S
D
S
D
P
E
M
W
E
L
L
Q
R
E
K
D
R
Q
C
R
G
L
E
L
I
A
S
E
N
F
C
S
R
A
A
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
K
R
Y
Y
G
G
A
E
V
V
D
E
I
E
L
L
C
Q
R
R
A
L
E
A
F
D
L
D
----
P
A
Q
W
G
V
N
V
Q
P
Y
S
G
S
P
A
N
L
A
V
Y
T
A
L
L
Q
P
H
D
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
Y
M
S
DVK
R
-------
I
S
A
T
S
I
F
F
E
S
M
P
Y
K
L
N
P
K
T
G
L
I
D
Y
N
Q
L
A
L
T
A
R
L
F
R
P
R
L
I
I
A
G
T
S
A
Y
A
R
L
I
-
D
Y
A
R
M
R
E
V
C
D
E
V
K
A
H
L
L
A
D
M
A
H
I
S
G
L
V
A
A
K
V
I
P
S
P
F
K
H
A
D
I
V
T
T
T
T
H
K
T
L
R
G
A
R
S
G
L
I
------------
F
---
Y
R
-
K
GVKAIPY--------
T
--------
F
E
D
R
I
N
F
A
V
F
P
S
L
Q
G
G
P
H
N
H
A
I
A
A
V
-
A
V
A
L
K
Q
A
C
T
P
M
F
R
E
Y
S
L
Q
V
L
K
N
A
R
A
M
A
D
A
L
-
L
-----
E
R
G
Y
S
L
V
S
G
G
T
D
N
H
L
V
L
V
D
L
R
P
K
-
G
L
D
G
A
R
A
E
R
V
L
E
L
V
S
I
T
A
N
K
N
T
C
P
G
D
-
R
S
A
I
T
P
G
G
L
R
L
G
A
P
A
L
T
S
R
Q
F
R
----
E
D
D
F
R
R
V
V
D
F
----
I
D
E
G
V
-
N
I
-
G
L
E
V
K
S
K
TA
K
L
Q
D
F
K
S
F
L
L
K
D
S
E
T
S
-------------------------
Q
-
R
--------
L
-
A
N
-
L
R
Q
R
V
E
Q
F
A
R
A
F
P
M
--------------------------
70
PsiBlast_CBE
75.40
53%
-90
- C1 -
3G8M
1
GLYA_ECOLI
A:
[8-416]
---------------
I
A
D
Y
D
A
E
L
W
Q
A
M
E
Q
E
K
V
R
Q
E
E
H
I
E
L
I
A
S
E
N
Y
T
S
P
R
V
M
Q
A
Q
G
S
Q
L
T
N
K
F
A
E
G
Y
P
G
K
R
Y
Y
G
G
C
E
Y
V
D
I
V
E
Q
L
A
I
D
R
A
K
E
L
F
G
A
D
----
Y
A
----
N
V
Q
P
H
S
G
S
Q
A
N
F
A
V
Y
T
A
L
L
E
P
G
D
T
V
L
G
M
N
L
A
H
G
G
H
L
T
H
G
S
-----
P
-------
V
N
F
S
G
K
L
Y
N
I
V
P
Y
G
I
D
A
T
G
H
-
I
D
Y
A
D
L
E
K
Q
A
K
E
H
K
P
K
M
I
I
G
G
F
S
A
Y
S
G
V
V
-
D
W
A
K
M
R
E
I
A
D
S
I
G
A
Y
L
F
V
D
M
A
H
V
A
G
L
V
A
A
G
V
Y
P
N
P
V
P
H
A
H
V
V
T
T
T
T
H
K
T
L
A
G
P
R
G
G
L
I
------------
L
A
K
G
G
S
-
E
---------------
E
--------
L
Y
K
K
L
N
S
A
V
F
P
G
G
Q
G
G
P
L
M
H
V
I
A
G
K
-
A
V
A
L
K
E
A
M
E
P
E
F
K
T
Y
Q
Q
Q
V
A
K
N
A
K
A
M
V
E
V
F
-
L
-----
E
R
G
Y
K
V
V
S
G
G
T
D
N
H
L
F
L
V
D
L
V
D
K
-
N
L
T
G
K
E
A
D
A
A
L
G
R
A
N
I
T
V
N
K
N
S
V
P
N
D
P
K
S
P
F
V
T
S
G
I
R
V
G
T
P
A
I
T
R
R
G
F
K
----
E
A
E
A
K
E
L
A
G
W
----
M
C
D
V
L
D
S
I
-
N
----------------------
D
E
-------------------------
A
-
V
--------
I
-
E
R
-
I
K
G
K
V
L
D
I
C
A
R
Y
P
V
Y
-------------------------
111
HHSearch
75.01
48%
-87
- C1 -
1RV3
4
GLYC_RABIT
A:
[23-482]
-------------
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
-----
M
T
DKKKIS
A
T
S
I
F
--
F
E
S
M
A
Y
K
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
------------
F
---
Y
R
-
R
---------------
G
VRSEILYN
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
---
E
--
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
K
-
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
----
I
H
R
G
I
-
E
L
-
T
----------------------
V
Q
I
Q
D
D
T
GPRAT
L
K
E
F
K
E
K
L
A
G
DEKHQ
R
-
A
--------
V
-
R
A
-
L
R
Q
E
V
E
S
F
A
A
L
F
P
L
P
G
L
P
G
---------------------
88
PsiBlast_CBE
72.75
46%
-89
- C1 -
1CJ0
2
GLYC_RABIT
B:
[8-411]
-----------
L
A
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DKK
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
V
RSVD-------
K
-
E
I
L
Y
------------
N
--------
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
-----
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
K
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
----
I
------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
70.82
46%
-88
- C1 -
1RVU
3
GLYC_RABIT
B:
[21-424]
-----------
L
A
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
Q
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DKK
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRSVD-------
K
-
E
I
L
Y
------------
N
--------
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
-----
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
K
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
----
I
------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
70.60
46%
-88
- C1 -
1RVY
3
GLYC_RABIT
A:
[21-424]
-----------
L
A
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
Q
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DKK
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRS-----------
E
ILY------------
N
--------
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
-----
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
K
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
----
I
------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
70.33
46%
-86
- C1 -
1RV4
4
GLYC_RABIT
A:
[21-424]
-----------
L
A
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DKK
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRS-----------
E
ILY------------
N
--------
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
-----
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
K
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
----
I
------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
70.07
46%
-87
- C1 -
1RVY
3
GLYC_RABIT
B:
[21-424]
-----------
L
A
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
Q
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DKK
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRSVD-------
K
-
E
I
L
Y
------------
N
--------
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
-----
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
K
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
----
I
------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
70.04
46%
-87
- C1 -
1RV3
4
GLYC_RABIT
A:
[21-424]
-----------
L
A
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DKK
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRS-----------
E
ILY------------
N
--------
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
-----
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
K
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
----
I
------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
69.97
46%
-88
- C1 -
1CJ0
2
GLYC_RABIT
A:
[8-411]
-----------
L
A
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DKK
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRSVD----------ILY------------
N
--------
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
-----
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
K
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
----
I
------------------------------------------------------------------------------------------------------------------
102
Fugue
69.77
44%
-84
- C1 -
1BJ4
1
GLYC_HUMAN
A:
[1-470]
DA
D
L
W
S
S
H
D
A
M
L
A
Q
P
L
K
D
S
D
V
E
V
Y
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
F
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
K
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DKK
K
-------
I
S
A
T
S
I
F
F
E
S
M
P
Y
K
V
N
P
D
T
G
Y
I
N
Y
D
Q
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
E
Y
A
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
A
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
------------
F
---
Y
R
-
K
G
VKSVDPATG
K
E
I
L
Y
N
--------
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
L
E
F
K
V
Y
Q
H
Q
V
V
A
N
C
R
A
L
S
E
A
L
-
T
E
L
-----
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
R
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
----
I
H
R
G
I
-
E
L
-
T
----------------------
L
Q
-------------------------
I
-
Q
--------
S
-
D
T
G
V
A
A
T
L
K
E
F
K
E
R
L
A
G
D
K
Y
Q
A
A
V
Q
A
L
R
E
E
V
E
S
F
A
S
L
F
PLPGL
93
PsiBlast_CBE
69.63
46%
-87
- C1 -
1RVU
3
GLYC_RABIT
A:
[21-424]
-----------
L
A
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
Q
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DKK
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRS-----------
E
ILY------------
N
--------
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
-----
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
K
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
----
I
------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
69.37
46%
-85
- C1 -
1RV4
4
GLYC_RABIT
B:
[21-424]
-----------
L
A
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DKK
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRSVD-------
K
-
E
I
L
Y
------------
N
--------
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
-----
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
K
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
----
I
------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
69.31
46%
-87
- C1 -
1RV3
4
GLYC_RABIT
B:
[21-424]
-----------
L
A
Q
P
L
K
D
S
D
A
E
V
Y
D
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
L
G
Y
P
G
Q
R
Y
Y
G
G
T
E
H
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
G
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DKK
K
-------
I
S
A
T
S
I
F
F
E
S
M
A
Y
K
V
N
P
D
T
G
Y
I
D
Y
D
R
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
D
Y
G
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
V
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
R
G
VRSVD-------
K
-
E
I
L
Y
------------
N
--------
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
P
E
F
K
E
Y
Q
R
Q
V
V
A
N
C
R
A
L
S
A
A
L
-
V
-----
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
K
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
----
I
------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
68.45
45%
-81
- C1 -
1BJ4
1
GLYC_HUMAN
A:
[12-443]
-----------
L
A
Q
P
L
K
D
S
D
V
E
V
Y
N
I
I
K
K
E
S
N
R
Q
R
V
G
L
E
L
I
A
S
E
N
F
A
S
R
A
V
L
E
A
L
G
S
C
L
N
N
K
Y
S
E
G
Y
P
G
Q
R
Y
Y
G
G
T
E
F
I
D
E
L
E
T
L
C
Q
K
R
A
L
Q
A
Y
K
L
D
PQC
W
G
V
----
N
V
Q
P
Y
S
G
S
P
A
N
F
A
V
Y
T
A
L
V
E
P
H
G
R
I
M
G
L
D
L
P
D
G
G
H
L
T
H
G
F
M
T
DKK
K
-------
I
S
A
T
S
I
F
F
E
S
M
P
Y
K
V
N
P
D
T
G
Y
I
N
Y
D
Q
L
E
E
N
A
R
L
F
H
P
K
L
I
I
A
G
T
S
C
Y
S
R
N
L
-
E
Y
A
R
L
R
K
I
A
D
E
N
G
A
Y
L
M
A
D
M
A
H
I
S
G
L
V
A
A
G
V
V
P
S
P
F
E
H
C
H
V
V
T
T
T
T
H
K
T
L
R
G
C
R
A
G
M
I
F
Y
R
K
G
VKSVDPA
T
---
G
K
-
E
I
L
Y
------------
N
--------
L
E
S
L
I
N
S
A
V
F
P
G
L
Q
G
G
P
H
N
H
A
I
A
G
V
-
A
V
A
L
K
Q
A
M
T
L
E
F
K
V
Y
Q
H
Q
V
V
A
N
C
R
A
L
S
E
A
L
------
T
E
L
G
Y
K
I
V
T
G
G
S
D
N
H
L
I
L
V
D
L
R
S
K
-
G
T
D
G
G
R
A
E
K
V
L
E
A
C
S
I
A
C
N
K
N
T
C
P
G
D
-
R
S
A
L
R
P
S
G
L
R
L
G
T
P
A
L
T
S
R
G
L
L
----
E
K
D
F
Q
K
V
A
H
F
I
H
R
G
I
E
L
T
L
-
Q
I
-
Q
----------------------
S
D
-------------------------
T
-
G
--------
V
-
A
A
T
L
K
E
F
K
E
R
L
A
-------------------------------