@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1143: (2016-04-28 )
MAGPLSGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSVDGISRDAMLRNRRIVTADLKSDQGLELALKLIAKADVLIEGYRPGVTERLGLGPEECAKVNDRLIYARMTGWGQTGPRSQQAGHDINYISLNGILHAIGRGDERPVPPLNLVGDFGGGSMFLLVGILAALWERQSSGKGQVVDAAMVDGSSVLIQMMWAMRATGMWTDTRGANMLDGGAPYYDTYECADGRYVAVGAIEPQFYAAMLAGLGLDAAELPPQNDRARWPELRALLTEAFASHDRDHWGAVFANSDACVTPVLAFGEVHNEPHIIERNTFYEANGGWQPMPAPRFSRTASSQPRPPAATIDIEAVLTDWDG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGPLSG
L
R
V
V
E
L
AGIGPGPH
A
A
M
I
LGDLGA
D
V
V
R
IDRPSSVDGI
S
R
D
A
M
LRN
R
R
I
V
T
A
DLKSDQ
G
L
E
L
A
L
K
L
I
A
KA
D
V
L
I
EGYRPGV
T
E
RLGL
G
P
E
E
C
A
KVND
R
L
I
Y
A
R
MTGWGQTGPRSQQAGHDI
N
Y
I
S
L
N
G
I
L
H
A
IGRGDERPVPP
L
N
L
V
GDFGG
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
RQSSGK
G
Q
V
V
D
A
A
MVD
G
S
S
V
L
I
Q
M
M
W
A
M
RATGMWTDTRGANMLDGGAPYY
D
T
Y
ECADG
R
Y
V
A
V
GAI
E
P
Q
F
Y
A
A
M
L
A
GLGL
D
A
AELPPQNDRAR
W
P
E
L
R
A
L
L
T
E
A
F
A
SHDRDH
W
G
A
V
FANSD
A
C
V
T
P
V
L
A
F
G
EVHNEP
H
I
I
ERN
T
F
Y
EANGGWQPMPAPRFSRTASSQPRPP
A
A
T
I
D
I
E
A
V
LTDWDG
27
PsiBlast_CBE
97.80
100%
-117
- C8 -
2GD2
3
?
D:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
33
PsiBlast_CBE
97.31
100%
-114
- C8 -
2GCI
4
?
D:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
28
PsiBlast_CBE
97.17
100%
-116
- C8 -
2GD2
3
?
C:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
5
PsiBlast_PDB
96.96
100%
-115
- C8 -
2GD2
3
?
A:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
29
PsiBlast_CBE
96.90
100%
-114
- C8 -
2GD2
3
?
B:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
26
PsiBlast_CBE
96.90
100%
-116
- C8 -
2GD6
1
?
B:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
40
PsiBlast_CBE
96.86
100%
-114
- C8 -
1X74
5
?
C:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
23
PsiBlast_CBE
96.74
100%
-113
- C8 -
2YIM
4
?
B:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
S
----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
21
PsiBlast_CBE
96.73
100%
-114
- C8 -
2YIM
4
?
D:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
S
----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
1
PsiBlast_PDB
96.54
100%
-115
- C8 -
1X74
5
?
A:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
22
PsiBlast_CBE
96.53
100%
-114
- C8 -
2YIM
4
?
C:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
S
----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
7
PsiBlast_PDB
96.52
100%
-114
- C8 -
2YIM
4
?
A:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
S
----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
31
PsiBlast_CBE
96.50
100%
-114
- C8 -
2GD0
3
?
C:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
24
PsiBlast_CBE
96.49
100%
-116
- C8 -
2GD6
3
?
D:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
39
PsiBlast_CBE
96.48
100%
-114
- C8 -
1X74
8
?
D:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
36
PsiBlast_CBE
96.47
100%
-113
- C8 -
2GCE
2
?
D:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
38
PsiBlast_CBE
96.46
100%
-114
- C8 -
2GCE
2
?
B:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
3
PsiBlast_PDB
96.43
100%
-115
- C8 -
2GCI
4
?
A:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
35
PsiBlast_CBE
96.40
100%
-115
- C8 -
2GCI
4
?
B:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G
34
PsiBlast_CBE
96.35
100%
-114
- C8 -
2GCI
4
?
C:
[2-360]
-
A
G
P
L
S
G
L
R
V
V
E
L
A
G
I
G
P
G
P
H
A
A
M
I
L
G
D
L
G
A
D
V
V
R
I
D
R
P
-----
I
S
R
D
A
M
L
R
N
R
R
I
V
T
A
D
L
K
S
D
Q
G
L
E
L
A
L
K
L
I
A
K
A
D
V
L
I
E
G
Y
R
P
G
V
T
E
R
L
G
L
G
P
E
E
C
A
K
V
N
D
R
L
I
Y
A
R
M
T
G
W
G
Q
T
G
P
R
S
Q
Q
A
G
H
D
I
N
Y
I
S
L
N
G
I
L
H
A
I
G
R
G
D
E
R
P
V
P
P
L
N
L
V
G
D
F
G
G
G
S
M
F
L
L
V
G
I
L
A
A
L
W
E
R
Q
S
S
G
K
G
Q
V
V
D
A
A
M
V
D
G
S
S
V
L
I
Q
M
M
W
A
M
R
A
T
G
M
W
T
D
T
R
G
A
N
M
L
D
G
G
A
P
Y
Y
D
T
Y
E
C
A
D
G
R
Y
V
A
V
G
A
I
E
P
Q
F
Y
A
A
M
L
A
G
L
G
L
D
A
A
E
L
P
P
Q
N
D
R
A
R
W
P
E
L
R
A
L
L
T
E
A
F
A
S
H
D
R
D
H
W
G
A
V
F
A
N
S
D
A
C
V
T
P
V
L
A
F
G
E
V
H
N
E
P
H
I
I
E
R
N
T
F
Y
E
A
N
G
G
W
Q
P
M
P
A
P
R
F
S
R
T
A
S
S
Q
P
R
P
P
A
A
T
I
D
I
E
A
V
L
T
D
W
D
G