@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1151c: (2016-04-29 )
MRVAVLSGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWLRNPERVWGWYLWRHYLVANVEPNDGHRAIAAWQDHAEVSVITQNVDDLHERAGSGAVHHLHGSLFEFRCARCGVPYTDALPEMPEPAIEVEPPVCDCGGLIRPDIVWFGEPLPEEPWRSAVEATGSADVMVVVGTSAIVYPAAGLPDLALARGTAVIEVNPEPTPLSGSATISIRESASQALPGLLERLPALLK
Atome Classification :
(74 SA)
-----------------------.........10........20.......---.30---.-.......40........50..--.-.....60........70....-----..----.-----.80-.-.......90.....--...100.......110....-------.-------..-120...-------....---------------.--.130...-..-----.-.---140.-......150.....---..160-----.........---170.......180.......190.......200.......210..-----......220.......230.....--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------
M
R
V
A
V
LSGAGISAESGVPTFRDDKNG
L
W
---
A
RF---D-PYELSSTQGWLR
N
P
E
R
V
W
G
W
Y
--
L
-
W
R
H
Y
L
V
A
NVEPNDG
H
R
A
I
A
A
W-----QD----H-----A
E
V
-
S
-
V
I
T
Q
N
V
D
D
L
H
E
RAG--SGA
V
H
H
L
HG
S
L
F
E
F
R
C
A
RCG-------V-------PY-T--DAL-------PEMP---------------E--P
A
I
EVEP-PV-----C-D---CGGL-IRP
D
I
V
WFGEPL
P
E
---
E
P
W
-------
R
S
A
V
E
ATGS---A
D
V
M
V
V
VGT
S
A
I
V
YPAAGLP
D
L
ALAR
G
T
A
V
I
E
VNPEPTPLSG-
S
A
-----
T
I
S
I
R
E
S
A
S
Q
A
L
P
G
L
L
E
R
L
P
A
LLK--
1
PsiBlast_PDB
92.61
46%
-91
- C5 -
1M2G
2
NPD1_ARCFU
A:
[15-240]
-------------------------
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
-
K
D
G
L
W
---
N
R
Y
---
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
--
A
-
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
----
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
-------
N
-------
S
F
E
V
--
E
S
A
-------
P
K
I
P
---------------
P
--
L
-------
P
K
-----
C
-
D
K--
C
G
S
L
-
L
R
P
G
V
V
W
F
G
E
M
L
P
P
---
D
V
L
-------
D
R
A
M
R
E
V
E
R
---
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
-------
4
PsiBlast_PDB
92.37
45%
-91
- C5 -
1M2H
2
NPD1_ARCFU
A:
[15-240]
-------------------------
L
V
A
L
T
G
A
G
V
A
A
E
S
G
I
P
T
F
R
G
-
K
D
G
L
W
---
N
R
Y
---
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
--
A
-
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
----
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
-------
N
-------
S
F
E
V
--
E
S
A
-------
P
K
I
P
---------------
P
--
L
-------
P
K
-----
C
-
D
K--
C
G
S
L
-
L
R
P
G
V
V
W
F
G
E
M
L
P
P
---
D
V
L
-------
D
R
A
M
R
E
V
E
R
---
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
-------
5
PsiBlast_PDB
92.34
46%
-89
- C5 -
1M2J
2
NPD1_ARCFU
A:
[15-237]
-------------------------
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
-
K
D
G
L
W
---
N
R
Y
---
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
--
A
-
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
N
Q
A
F
A
E
L
-----
E
R
----
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
-------
N
-------
S
F
E
V
--
E
S
A
-------
P
K
I
P
---------------
P
--
L
-------
P
K
-----
C
-
D
K--
C
G
S
L
-
L
R
P
G
V
V
W
F
G
E
M
L
P
P
---
D
V
L
-------
D
R
A
M
R
E
V
E
R
---
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
----------
3
PsiBlast_PDB
92.23
45%
-90
- C5 -
4TWI
2
NPD1_ARCFU
A:
[15-244]
-------------------------
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
-
K
D
G
L
W
---
N
R
Y
---
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
--
A
-
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
----
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
-------
N
-------
S
F
E
V
--
E
S
A
-------
P
K
I
P
---------------
P
--
L
-------
P
K
-----
C
-
D
K--
C
G
S
L
-
L
R
P
G
V
V
W
F
G
E
M
L
P
P
---
D
V
L
-------
D
R
A
M
R
E
V
E
R
---
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
L
---
21
PsiBlast_CBE
91.59
45%
-89
- C5 -
1ICI
2
NPD1_ARCFU
B:
[26-255]
-------------------------
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
-
K
D
G
L
W
---
N
R
Y
---
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
--
A
-
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
----
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
-------
N
-------
S
F
E
V
--
E
S
A
-------
P
K
I
P
---------------
P
--
L
-------
P
K
-----
C
-
D
K--
C
G
S
L
-
L
R
P
G
V
V
W
F
G
E
M
L
P
P
---
D
V
L
-------
D
R
A
M
R
E
V
E
R
---
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
L
---
6
PsiBlast_PDB
91.15
45%
-90
- C5 -
1M2K
2
NPD1_ARCFU
A:
[15-240]
-------------------------
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
-
K
D
G
L
W
---
N
R
Y
---
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
--
A
-
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
----
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
-------
N
-------
S
F
E
V
--
E
S
A
-------
P
K
I
P
---------------
P
--
L
-------
P
K
-----
C
-
D
K--
C
G
S
L
-
L
R
P
G
V
V
W
A
G
E
M
L
P
P
---
D
V
L
-------
D
R
A
M
R
E
V
E
R
---
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
-------
24
PsiBlast_CBE
90.93
39%
-103
- C5 -
4F56
3
SIR5_HUMAN
B:
[24-272]
-------------------------
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
A
G
G
Y
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
----
R
L
G
K
Q
G
R
R
V
-
V
-
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
-------
V
V
A
E
N
YKS
P
I
-
C
--
P
A
L
SGKGAPE
P
G
T
Q
---------------
D
--
A
S
I
P
V
E
K
L
P
R
-----
C
-
E
EAG
C
G
G
L
-
L
R
P
H
V
V
W
F
G
E
N
L
D
P
---
A
I
L
-------
E
E
V
D
R
E
L
A
H
---
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
T
N
-
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
----------
2
PsiBlast_PDB
90.84
45%
-92
- C5 -
1ICI
2
NPD1_ARCFU
A:
[26-255]
-------------------------
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
-
K
D
G
L
W
---
N
R
Y
---
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
--
A
-
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
----
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
-------
N
-------
S
F
E
V
--
E
S
A
-------
P
K
I
P
---------------
P
--
L
-------
P
K
-----
C
-
D
K--
C
G
S
L
-
L
R
P
G
V
V
W
F
G
E
M
L
P
P
---
D
V
L
-------
D
R
A
M
R
E
V
E
R
---
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
L
---
10
PsiBlast_PDB
90.18
39%
-106
- C5 -
4F4U
2
SIR5_HUMAN
A:
[24-272]
-------------------------
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
-----
G
Y
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
----
R
L
G
K
Q
G
R
R
V
-
V
-
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
-------
V
V
A
E
N
YKS
P
I
-
C
--
P
A
L
SGKGAPE
P
G
T
Q
---------------
D
--
A
S
I
P
V
E
K
L
P
R
-----
C
-
E
EAG
C
G
G
L
-
L
R
P
H
V
V
W
F
G
E
N
L
D
P
---
A
I
L
-------
E
E
V
D
R
E
L
A
H
---
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
T
N
-
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
----------
11
PsiBlast_PDB
90.13
39%
-99
- C5 -
4F56
3
SIR5_HUMAN
A:
[24-272]
-------------------------
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
A
G
G
Y
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
----
R
L
G
K
Q
G
R
R
V
-
V
-
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
-------
V
V
A
E
N
YKS
P
I
-
C
--
P
A
L
SGKGAPE
P
G
T
Q
---------------
D
--
A
S
I
P
V
E
K
L
P
R
-----
C
-
E
EAG
C
G
G
L
-
L
R
P
H
V
V
W
F
G
E
N
L
D
P
---
A
I
L
-------
E
E
V
D
R
E
L
A
H
---
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
T
N
-
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
----------
26
PsiBlast_CBE
90.10
39%
-105
- C5 -
4G1C
3
SIR5_HUMAN
B:
[18-266]
-------------------------
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
A
G
G
Y
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
----
R
LGKQG
R
R
V
-
V
-
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
-------
V
VAENYKS
P
I
-
C
--
P
A
L
SGKGAPE
P
G
T
Q
---------------
D
--
A
S
I
P
V
E
K
L
P
R
-----
C
-
E
EAG
C
G
G
L
-
L
R
P
H
V
V
W
F
G
E
N
L
D
P
---
A
I
L
-------
E
E
V
D
R
E
L
A
H
---
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
T
N
-
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
----------
23
PsiBlast_CBE
89.94
39%
-99
- C5 -
2NYR
2
SIR5_HUMAN
B:
[22-270]
-------------------------
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
A
G
G
Y
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
----
R
LGKQG
R
R
V
-
V
-
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
-------
V
VAENYKS
P
I
-
C
--
P
A
L
SGKGAPE
P
G
T
Q
---------------
D
--
A
S
I
P
V
E
K
L
P
R
-----
C
-
E
EAG
C
G
G
L
-
L
R
P
H
V
V
W
F
G
E
N
L
D
P
---
A
I
L
-------
E
E
V
D
R
E
L
A
H
---
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
---------------
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
----------
9
PsiBlast_PDB
89.60
39%
-101
- C5 -
3RIY
3
SIR5_HUMAN
A:
[24-272]
-------------------------
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
A
G
G
Y
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
----
R
L
G
K
Q
G
R
R
V
-
V
-
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
-------
V
V
A
E
N
YKS
P
I
-
C
--
P
A
L
SGKGAPE
P
G
T
Q
---------------
D
--
A
S
I
P
V
E
K
L
P
R
-----
C
-
E
EAG
C
G
G
L
-
L
R
P
H
V
V
W
F
G
E
N
L
D
P
---
A
I
L
-------
E
E
V
D
R
E
L
A
H
---
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
T
N
-
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
----------
22
PsiBlast_CBE
89.58
45%
-92
- C5 -
1M2N
2
NPD1_ARCFU
B:
[15-240]
-------------------------
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
-
K
D
G
L
W
---
N
R
Y
---
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
--
A
-
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
----
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
G
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
-------
N
-------
S
F
E
V
--
E
S
A
-------
P
K
I
P
---------------
P
--
L
-------
P
K
-----
C
-
D
K--
C
G
S
L
-
L
R
P
G
V
V
W
A
G
E
M
L
P
P
---
D
V
L
-------
D
A
A
M
R
E
V
E
R
---
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
-------
8
PsiBlast_PDB
89.53
39%
-103
- C5 -
2NYR
2
SIR5_HUMAN
A:
[22-270]
-------------------------
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
A
G
G
Y
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
----
R
L
G
K
Q
G
R
R
V
-
V
-
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
-------
V
V
A
E
N
YKS
P
I
-
C
--
P
A
L
SGKGAPE
P
G
T
Q
---------------
D
--
A
S
I
P
V
E
K
L
P
R
-----
C
-
E
EAG
C
G
G
L
-
L
R
P
H
V
V
W
F
G
E
N
L
D
P
---
A
I
L
-------
E
E
V
D
R
E
L
A
H
---
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
--------------
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
----------
7
PsiBlast_PDB
88.73
45%
-88
- C5 -
1M2N
2
NPD1_ARCFU
A:
[15-240]
-------------------------
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
-
K
D
G
L
W
---
N
R
Y
---
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
--
A
-
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
----
L
-----
G
V
L
-
K
C
L
I
T
Q
N
V
D
G
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
-------
N
-------
S
F
E
V
--
E
S
A
-------
P
K
I
P
---------------
P
--
L
-------
P
K
-----
C
-
D
K--
C
G
S
L
-
L
R
P
G
V
V
W
A
G
E
M
L
P
P
---
D
V
L
-------
D
A
A
M
R
E
V
E
R
---
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
-------
12
PsiBlast_PDB
88.66
39%
-99
- C5 -
4G1C
4
SIR5_HUMAN
A:
[18-266]
-------------------------
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
A
G
G
Y
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
----
R
L
G
K
Q
G
R
R
V
-
V
-
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
-------
V
V
A
E
N
YKS
P
I
-
C
--
P
A
L
SGKGAPE
P
G
T
Q
---------------
D
--
A
S
I
P
V
E
K
L
P
R
-----
C
-
E
EAG
C
G
G
L
-
L
R
P
H
V
V
W
F
G
E
N
L
D
P
---
A
I
L
-------
E
E
V
D
R
E
L
A
H
---
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
T
N
-
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
----------
16
PsiBlast_PDB
88.50
39%
-104
- C5 -
2B4Y
3
SIR5_HUMAN
A:
[22-270]
-------------------------
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
--------
G
Y
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
----
R
L
G
K
Q
G
R
R
V
-
V
-
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
-------
V
V
A
E
N
YKS
P
I
-
C
--
P
A
L
SGKGAPE
P
G
T
Q
---------------
D
--
A
S
I
P
V
E
K
L
P
R
-----
C
-
E
EAG
C
G
G
L
-
L
R
P
H
V
V
W
F
G
E
N
L
D
P
---
A
I
L
-------
E
E
V
D
R
E
L
A
H
---
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
T
N
-
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
----------
95
HHSearch
88.34
40%
-88
- C5 -
3RIY
3
SIR5_HUMAN
A:
[22-273]
-----------------------
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
A
-
G
G
Y
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
R
L
G
K
Q
G----
R
R
V
-
V
-
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
-------
V
-------
V
A
-
E
--
N
Y
K
-------
S
P
I
C
PALSGKGAPEPGTQD
A
--
S
I
P
V
E
K
L
-
P
R
-----
C
E
E
AG-
C
G
G
L
-
L
R
P
H
V
V
W
F
G
E
N
L
D
P
---
A
I
L
-------
E
E
V
D
R
E
L
A
H
---
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
T
N
-
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
A
---------
82
Fugue
88.26
43%
-88
- C5 -
1ICI
2
NPD1_ARCFU
A:
[1-256]
GSHH
H
H
H
H
G
SHMD
E
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
----
G
K
D
---
G
L
W
NRY
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
--
A
-
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
----
L
G----
V
L
K
-
C
-
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
SR--
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
---------
C
-------
N
N
-
S
--
F
E
V
-------
E
S
A
P
------------------
K
I
P
--
P
L
-
P
K
-----
C
D
K
---
C
G
S
L
-
L
R
P
G
V
V
W
F
G
E
M
L
P
P
---
D
V
L
-------
D
R
A
M
R
E
V
E
R
---
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
----
T
-
P
-LTPIA
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
--
K
A
L
S
81
Fugue
88.21
46%
-79
- C5 -
1ICI
2
NPD1_ARCFU
A:
[1-256]
GSHH
H
H
H
H
G
SHMD
E
K
L
L
K
T
I
A
E
S
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
-
K
D
G
L
W
---
N
R
Y
---
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
--
A
-
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
----
L
G----
V
L
K
-
C
-
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
-------
N
-------
S
F
-
E
--
V
E
-----------
S
---------------
A
--
P
K
I
P
P
L
P
-
K
C
-----
D
-
K
---
C
G
S
L
-
L
R
P
G
V
V
W
F
G
E
M
L
P
P
---
D
V
L
-------
D
R
A
M
R
E
V
E
R
---
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
L
S
--
25
PsiBlast_CBE
88.15
39%
-99
- C5 -
3RIY
3
SIR5_HUMAN
B:
[24-272]
-------------------------
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
A
G
G
Y
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
----
R
LGKQG
R
R
V
-
V
-
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
-------
V
VAENYKS
P
I
-
C
--
P
A
L
SGKGAPE
P
G
T
Q
---------------
D
--
A
S
I
P
V
E
K
L
P
R
-----
C
-
E
EAG
C
G
G
L
-
L
R
P
H
V
V
W
F
G
E
N
L
D
P
---
A
I
L
-------
E
E
V
D
R
E
L
A
H
---
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
T
N
-
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
----------
91
HHSearch
87.93
45%
-77
* C5 *
1M2K
2
NPD1_ARCFU
A:
[13-243]
-----------------------
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
G
K
-
D
G
L
W
---
N
R
Y
---
R
-
P
E
E
L
A
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
--
A
-
W
R
M
E
K
V
F
N
A
Q
P
N
K
A
H
Q
A
F
A
E
L
-----
E
R
----
L
G----
V
L
K
-
C
-
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
-------
N
-------
S
F
-
E
--
V
E
S
-------
A
P
----------------------
K
I
P
P
L
-
P
K
-----
C
D
K
---
C
G
S
L
-
L
R
P
G
V
V
W
A
G
E
M
L
P
P
---
D
V
L
-------
D
R
A
M
R
E
V
E
R
---
A
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
S
L
P
L
I
V
K
Q
R
G
G
A
I
I
E
I
N
P
D
E
T
P
L
T
P
-
I
A
-----
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
H
V
R
K
A
----
19
PsiBlast_PDB
87.90
38%
-100
- C5 -
4UTV
4
SIR5_DANRE
A:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
-------------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
46
PsiBlast_CBE
87.74
38%
-98
- C5 -
4UTV
4
SIR5_DANRE
B:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
--------
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
43
PsiBlast_CBE
87.47
38%
-96
- C5 -
4UTZ
5
SIR5_DANRE
B:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
------
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
45
PsiBlast_CBE
87.15
38%
-94
- C5 -
4UTX
5
SIR5_DANRE
B:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
-------
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
20
PsiBlast_PDB
86.72
38%
-100
- C5 -
4UTX
6
SIR5_DANRE
A:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
T
Q
--------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
30
PsiBlast_CBE
86.65
42%
-84
- C5 -
1YC2
7
NPD2_ARCFU
C:
[20-249]
---------------------------
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
-
D
G
L
W
---
R
K
Y
---
D
-
P
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
--
M
E
M
K
D
K
L
F
A
--
E
P
N
P
A
H
Y
A
I
A
E
L
-----
E
R
----
M
-----
G
I
V
K
A
-
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
--
S
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
-------
E
-------
T
Y
-
D
----
W
-------
S
E
F
V
---------------
E
--
D
F
N
K
G
E
I
-
P
R
-----
C
R
K
---
C
G
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
---
R
T
L
-------
F
E
A
I
E
E
A
K
H
---
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
E
L
P
Y
I
A
K
K
A
G
A
K
M
I
I
V
N
A
E
P
T
M
A
D
P
-
I
F
-----
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
L
----
27
PsiBlast_CBE
86.65
39%
-92
- C5 -
4HDA
3
SIR5_HUMAN
B:
[26-274]
-------------------------
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
A
G
G
Y
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
L
A
F
A
H
N
P
S
R
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
G
S
K
E
P
N
A
G
H
R
A
I
A
E
C
-----
E
T
----
R
L
G
K
Q
G
R
R
V
-
V
-
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
-------
V
V
A
E
N
YKS
P
I
-
C
--
P
A
L
SGKGAPE
P
G
T
Q
---------------
D
--
A
S
I
P
V
E
K
L
P
R
-----
C
-
E
EAG
C
G
G
L
-
L
R
P
H
V
V
W
F
G
E
N
L
D
P
---
A
I
L
-------
E
E
V
D
R
E
L
A
H
---
C
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
G
V
P
V
A
E
F
N
T
E
T
T
P
A
T
N
-
R
F
-----
R
F
H
F
Q
G
P
C
G
T
T
L
P
E
A
L
----------
18
PsiBlast_PDB
86.48
38%
-97
- C5 -
4UTR
6
SIR5_DANRE
A:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
T
Q
--------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
40
PsiBlast_CBE
86.37
38%
-98
- C5 -
4UU8
4
SIR5_DANRE
A:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
T
Q
--------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
44
PsiBlast_CBE
86.16
38%
-96
- C5 -
4UTZ
4
SIR5_DANRE
A:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
T
Q
--------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
42
PsiBlast_CBE
86.07
38%
-99
- C5 -
4UU7
7
SIR5_DANRE
A:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
T
Q
--------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
38
PsiBlast_CBE
85.90
38%
-96
- C5 -
4UUA
5
SIR5_DANRE
A:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
T
Q
--------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
17
PsiBlast_PDB
85.82
38%
-98
- C5 -
4UTN
3
SIR5_DANRE
A:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
T
---------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
39
PsiBlast_CBE
85.68
38%
-94
- C5 -
4UU8
5
SIR5_DANRE
B:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
T
Q
-
R
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
36
PsiBlast_CBE
85.54
38%
-98
- C5 -
4UUB
5
SIR5_DANRE
A:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
T
Q
--------
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
37
PsiBlast_CBE
85.34
38%
-91
- C5 -
4UUA
5
SIR5_DANRE
B:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
T
Q
-
R
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
35
PsiBlast_CBE
85.12
38%
-95
- C5 -
4UUB
5
SIR5_DANRE
B:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
----
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
41
PsiBlast_CBE
84.72
38%
-88
- C5 -
4UU7
5
SIR5_DANRE
B:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
T
Q
-
R
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
48
PsiBlast_CBE
84.45
38%
-93
- C5 -
4UTN
4
SIR5_DANRE
B:
[26-275]
-------------------------
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
G
-
P
G
G
F
W
---
R
K
W
---
Q
-
A
Q
D
L
A
T
P
E
A
F
S
R
D
P
S
L
V
W
E
F
Y
--
H
-
Y
R
R
E
V
M
R
S
K
M
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
----
G
-----
R
S
V
-
V
-
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
N
HK
S
-------
P
I
-
C
--
P
A
L
DGKGAPD
P
N
T
K
---------------
E
--
A
R
I
P
V
E
L
L
P
R
-----
C
-
E
RKS
C
N
G
L
-
L
R
P
H
V
V
W
F
G
E
T
L
D
S
---
D
I
L
-------
T
A
V
E
R
E
L
E
K
---
C
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
G
V
P
V
A
E
F
N
M
E
C
T
P
A
T
Q
-
R
F
-----
K
Y
H
F
E
G
P
C
G
S
T
L
P
P
A
L
E
---------
31
PsiBlast_CBE
84.09
42%
-81
- C5 -
1YC2
7
NPD2_ARCFU
B:
[20-249]
---------------------------
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
G
E
-
D
G
L
W
---
R
K
Y
---
D
-
P
E
E
V
A
S
I
S
G
F
K
R
N
P
R
A
F
W
E
F
S
--
M
E
M
K
D
K
L
F
A
--
E
P
N
P
A
H
Y
A
I
A
E
L
-----
E
R
----
M
-----
G
I
V
K
A
-
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
--
S
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
-------
E
-------
T
Y
-
D
----
W
-------
S
E
F
V
---------------
E
--
D
F
N
K
G
E
I
-
P
R
-----
C
R
K
---
C
G
S
Y
Y
V
K
P
R
V
V
L
F
G
E
P
L
P
Q
---
R
T
L
-------
F
E
A
I
E
E
A
K
H
---
C
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
E
L
P
Y
I
A
K
K
A
G
A
K
M
I
I
V
N
A
E
P
T
M
A
D
P
-
I
F
-----
D
V
K
I
I
G
K
A
G
E
V
L
P
K
I
V
E
E
V
K
R
L
----
65
PsiBlast_CBE
77.76
32%
-92
- C5 -
3U31
4
SIR5_PLAF7
A:
[47-261]
------------------------
H
V
V
A
L
T
G
S
G
T
S
A
E
S
N
I
P
S
F
R
G
S
S
N
S
I
W
---
S
K
Y
---
D
-
P
R
I
Y
G
T
I
W
G
F
W
K
Y
P
E
K
I
W
E
V
I
R
D
I
-
S
S
D
Y
---
E
I
E
I
N
N
G
H
V
A
L
S
T
L
-----
E
S
----
L
-----
G
Y
L
K
S
-
V
V
T
Q
N
V
D
G
L
H
E
A
S
G
--
N
T
K
V
I
S
L
H
G
N
V
F
E
A
V
C
C
T
C
N
K
I
-----
V
-------
K
L
-
N
--
K
I
M
-------
L
Q
K
T
---------------
S
--
H
F
M
H
Q
L
P
-
P
E
-----
C
-
P
---
C
G
G
I
-
F
K
P
N
I
I
L
F
G
E
V
V
S
S
---
D
L
L
-------
K
E
A
E
E
E
I
A
K
---
C
D
L
L
L
V
I
G
T
S
S
T
V
S
T
A
T
N
L
C
H
F
A
C
K
K
K
K
K
I
V
E
I
N
I
S
K
T
Y
I
T
N
-
K
M
-----
S
-------------------------
64
PsiBlast_CBE
77.38
32%
-94
- C5 -
3U3D
3
SIR5_PLAF7
A:
[47-261]
------------------------
H
V
V
A
L
T
G
S
G
T
S
A
E
S
N
I
P
S
F
R
G
S
S
N
S
I
W
---
S
K
Y
---
D
-
P
R
I
Y
G
T
I
W
G
F
W
K
Y
P
E
K
I
W
E
V
I
R
D
I
-
S
S
D
Y
---
E
I
E
I
N
N
G
H
V
A
L
S
T
L
-----
E
S
----
L
-----
G
Y
L
K
S
-
V
V
T
Q
N
V
D
G
L
H
E
A
S
G
--
N
T
K
V
I
S
L
H
G
N
V
F
E
A
V
C
C
T
C
N
K
I
-----
V
-------
K
L
-
N
--
K
I
M
-------
L
Q
K
T
---------------
S
--
H
F
M
H
Q
L
P
-
P
E
-----
C
-
P
---
C
G
G
I
-
F
K
P
N
I
I
L
F
G
E
V
V
S
S
---
D
L
L
-------
K
E
A
E
E
E
I
A
K
---
C
D
L
L
L
V
I
G
T
S
S
T
V
S
T
A
T
N
L
C
H
F
A
C
K
K
K
K
K
I
V
E
I
N
I
S
K
T
Y
I
T
N
-
K
M
-----
S
-------------------------
96
HHSearch
77.06
31%
-83
- C5 -
3U31
4
SIR5_PLAF7
A:
[46-281]
-----------------------
K
H
V
V
A
L
T
G
S
G
T
S
A
E
S
N
I
P
S
F
R
G
S
S
N
S
I
W
---
S
K
Y
---
D
-
P
R
I
Y
G
T
I
W
G
F
W
K
Y
P
E
K
I
W
E
V
I
--
R
-
D
I
S
S
D
-
Y
E
I
E
I
N
N
G
H
V
A
L
S
T
L
-----
E
S
----
L
G----
Y
L
K
-
S
-
V
V
T
Q
N
V
D
G
L
H
E
A
S
G
--
N
T
K
V
I
S
L
H
G
N
V
F
E
A
V
C
C
T
C
N
-------
K
-------
I
V
-
K
--
L
N
K
-------
I
M
L
Q
---------------
K
TS
H
F
M
H
Q
L
P
-
P
E
-----
C
-
P
---
C
G
G
I
-
F
K
P
N
I
I
L
F
G
E
V
V
S
S
---
D
L
L
-------
K
E
A
E
E
E
I
A
K
---
C
D
L
L
L
V
I
G
T
S
S
T
V
S
T
A
T
N
L
C
H
F
A
C
K
K
K
K
K
I
V
E
I
N
I
S
K
T
Y
I
T
N
K
M
S
-----
D
Y
H
V
C
A
K
F
S
E
-
L
T
K
V
A
N
I
L
K
G
-----
68
PsiBlast_CBE
76.48
35%
-79
- C5 -
2H59
4
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
G
-
P
N
G
I
Y
---
K
K
Y
---
S
-
Q
-
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
A
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
67
PsiBlast_CBE
75.38
35%
-76
- C5 -
2H59
4
NPD_THEMA
B:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
G
-
P
N
G
I
Y
---
K
K
Y
---
S
-
Q
-
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
A
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
VE
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
53
PsiBlast_CBE
74.12
36%
-88
- C5 -
3D81
2
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------------
Q
-
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
49
PsiBlast_CBE
73.86
36%
-88
- C5 -
4BV2
5
NPD_THEMA
B:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------------
Q
-
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
--------------------
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
93
HHSearch
73.72
34%
-76
- C5 -
1YC5
3
NPD_THEMA
A:
[14-244]
-----------------------
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
--------------------
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
G----
L
I
E
-
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
--
V
E
D
-------
V
I
K
-------------------
K
L
E
S
S
D
V
-
P
L
-----
C
D
D
---
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
M
E
E
G
G
------
61
PsiBlast_CBE
73.59
36%
-87
- C5 -
2H2D
2
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
---------------------
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
59
PsiBlast_CBE
73.34
36%
-86
- C5 -
2H2G
3
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------
Y
---
S
-
Q
-
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
54
PsiBlast_CBE
73.34
36%
-86
- C5 -
3D4B
3
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
---------------------
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
51
PsiBlast_CBE
73.32
36%
-83
- C5 -
4BUZ
4
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------
Y
---
S
-
Q
-
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
62
PsiBlast_CBE
73.28
36%
-87
- C5 -
1YC5
3
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------------
Q
-
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
50
PsiBlast_CBE
73.12
36%
-86
- C5 -
4BV2
5
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------
Y
---
S
-
Q
-
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
63
PsiBlast_CBE
72.99
35%
-78
- C5 -
2H4H
3
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
G
-
P
N
-----------------
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
Y
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
55
PsiBlast_CBE
72.87
36%
-85
- C5 -
2H4J
4
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-----------------
S
-
Q
-
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
58
PsiBlast_CBE
72.75
36%
-86
- C5 -
2H2H
2
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
---------------------
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
52
PsiBlast_CBE
72.62
36%
-83
- C5 -
3PDH
2
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------
Y
---
S
-
Q
-
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
60
PsiBlast_CBE
72.41
36%
-88
- C5 -
2H2F
2
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
--------------------
Q
-
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
56
PsiBlast_CBE
72.33
36%
-83
- C5 -
2H4F
3
NPD_THEMA
A:
[19-227]
----------------------------
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
G
-
P
---------
Y
---
S
-
Q
-
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
--
K
-
E
G
I
F
P
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
-----
E
E
----
K
-----
G
L
I
E
A
-
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
-------
K
-------
K
Y
-
T
V
E
D
V
I
-------
K
K
L
E
---------------
S
--
S
D
V
-----
P
L
-----
C
-
D
D--
C
N
S
L
-
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
---
D
A
L
-------
R
E
A
I
G
L
S
S
R
---
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
D
D
-
I
A
-----
T
L
K
-----------------------
77
PsiBlast_CBE
66.70
31%
-86
- C5 -
1Q17
3
HST2_YEAST
C:
[32-242]
------------------------
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
HNL
A
R
L
---
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
--
L
-
A
K
E
L
Y
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
-----
Q
D
----
K
-----
D
V
L
-
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
VK
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
C
G
-------
K
-------
V
Y
-
P
------------
P
Q
V
F
---------------
K
--
S
K
L
-
A
E
H
-
P
I
KDFVK
C
-
D
V--
C
G
E
L
-
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
----
K
HPQ
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
-------------------------------------------------------
76
PsiBlast_CBE
66.02
31%
-80
- C5 -
1Q1A
3
HST2_YEAST
A:
[22-232]
------------------------
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
HNL
A
R
L
---
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
--
L
-
A
K
E
L
Y
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
-----
Q
D
----
K
-----
D
V
L
-
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
VK
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
C
G
-------
K
-------
V
Y
-
P
------------
P
Q
V
F
---------------
K
--
S
K
L
-
A
E
H
-
P
I
KDFVK
C
-
D
V--
C
G
E
L
-
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T
---P
Q
-
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
-------------------------------------------------------
73
PsiBlast_CBE
65.30
31%
-81
- C5 -
2QQF
3
HST2_YEAST
A:
[40-250]
------------------------
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
---
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
--
L
-
A
K
E
L
Y
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
-----
Q
D
----
K
-----
D
V
L
-
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
VK
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
C
G
-------
K
-------
V
Y
-
P
------------
P
Q
V
F
---------------
K
--
S
K
L
-
A
E
H
-
P
I
KDFVK
C
-
D
V--
C
G
E
L
-
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
-----Q--
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
-------------------------------------------------------
75
PsiBlast_CBE
65.29
31%
-89
- C5 -
2OD7
3
HST2_YEAST
A:
[40-250]
------------------------
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
---
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
--
L
-
A
K
E
L
Y
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
-----
Q
D
----
K
-----
D
V
L
-
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
VK
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
C
G
-------
K
-------
V
Y
-
P
------------
P
Q
V
F
---------------
K
--
S
K
L
-
A
E
H
-
P
I
KDFVK
C
-
D
V--
C
G
E
L
-
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
-----Q--
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
-------------------------------------------------------
74
PsiBlast_CBE
65.18
31%
-82
- C5 -
2OD9
4
HST2_YEAST
A:
[40-250]
------------------------
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
---
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
--
L
-
A
K
E
L
Y
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
-----
Q
D
----
K
-----
D
V
L
-
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
VK
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
C
G
-------
K
-------
V
Y
-
P
------------
P
Q
V
F
---------------
K
--
S
K
L
-
A
E
H
-
P
I
KDFVK
C
-
D
V--
C
G
E
L
-
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T
---Q--
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
-------------------------------------------------------
72
PsiBlast_CBE
65.18
31%
-82
- C5 -
2QQG
4
HST2_YEAST
A:
[40-250]
------------------------
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
---
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
--
L
-
A
K
E
L
Y
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
-----
Q
D
----
K
-----
D
V
L
-
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
VK
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
C
G
-------
K
-------
V
Y
-
P
------------
P
Q
V
F
---------------
K
--
S
K
L
-
A
E
H
-
P
I
KDFVK
C
-
D
V--
C
G
E
L
-
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T
---Q--
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
-------------------------------------------------------
80
PsiBlast_CBE
65.15
31%
-85
- C5 -
2OD2
7
HST2_YEAST
A:
[40-250]
------------------------
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
---
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
--
L
-
A
K
E
L
Y
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
-----
Q
D
----
K
-----
D
V
L
-
K
R
V
Y
T
Q
N
F
D
T
L
E
R
Q
A
G
VK
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
C
G
-------
K
-------
V
Y
-
P
------------
P
Q
V
F
---------------
K
--
S
K
L
-
A
E
H
-
P
I
KDFVK
C
-
D
V--
C
G
E
L
-
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T
---Q--
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
-------------------------------------------------------
71
PsiBlast_CBE
65.05
31%
-81
- C5 -
1SZC
8
HST2_YEAST
A:
[29-239]
------------------------
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
---
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
--
L
-
A
K
E
L
Y
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
-----
Q
D
----
K
-----
D
V
L
-
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
VK
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
C
G
-------
K
-------
V
Y
-
P
------------
P
Q
V
F
---------------
K
--
S
K
L
-
A
E
H
-
P
I
KDFVK
C
-
D
V--
C
G
E
L
-
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T
---Q--
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
-------------------------------------------------------
70
PsiBlast_CBE
64.23
31%
-84
- C5 -
1SZD
7
HST2_YEAST
A:
[29-239]
------------------------
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
---
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
--
L
-
A
K
E
L
Y
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
-----
Q
D
----
K
-----
D
V
L
-
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
VK
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
C
G
-------
K
-------
V
Y
-
P
------------
P
Q
V
F
---------------
K
--
S
K
L
-
A
E
H
-
P
I
KDFVK
C
-
D
V--
C
G
E
L
-
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T
---Q--
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
-------------------------------------------------------
79
PsiBlast_CBE
63.97
31%
-80
- C5 -
1Q17
3
HST2_YEAST
A:
[32-242]
------------------------
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
HNL
A
R
L
---
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
--
L
-
A
K
E
L
Y
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
-----
Q
D
----
K
-----
D
V
L
-
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
VK
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
C
G
-------
K
-------
V
Y
-
P
------------
P
Q
V
F
---------------
K
--
S
K
L
-
A
E
H
-
P
I
KDFVK
C
-
D
V--
C
G
E
L
-
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
--------
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
-------------------------------------------------------
78
PsiBlast_CBE
63.54
31%
-78
- C5 -
1Q17
4
HST2_YEAST
B:
[32-242]
------------------------
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
HNL
A
R
L
---
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
--
L
-
A
K
E
L
Y
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
-----
Q
D
----
K
-----
D
V
L
-
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
VK
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
C
G
-------
K
-------
V
Y
-
P
------------
P
Q
V
F
---------------
K
--
S
K
L
-
A
E
H
-
P
I
KDFVK
C
-
D
V--
C
G
E
L
-
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
-----PQ-
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
-------------------------------------------------------