@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1175c: (2016-04-29 )
MTNPYPNLLSPLDLGFTTLRNRVVMGSMHTGLEDRARHIDRLADYFAERARGGVGLIITGGYAPNRTGWLLPFASELVTSAQARRHRRITRAVHDSGAKILLQILHAGRYAYHPLAVSASPIKAPITPFRPRALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYLLNQFLAPRTNKRTDSWGGTPANRRRFPVEIIRRSRAAVGCDFIICYRLSMADYVAEGQSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVTSVPGGAFVDISSAVAEHVTIPVVASNRINMPQAAERILAETQVRLISMARPMLSDPDWVLKAQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGRETQLVLSPTRRARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQFDMARRIPGKEEFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVLATGVAPRIPAIPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDVTELLVTDSSPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTKGPQGKRLGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLLAVDNVVVCAGQEPVRDLESELRRHGINPHIIGGAAVAAELDAKRAIKQGTELAARL
Atome Classification :
(20 SA)
.........10........20....-------.--...30...-.-....40........50........60....-....70.-..-......80...-.....90........100.......110------------------..------.-----------.----....120-...---.---------...130.......140.......150-------.......160.......-170........180.......190.......200..------.....210.......220..-.-.---...230..-----......240.......250.......260--...--....-270.-......280.......290.......300.......310.......320.......330.......340......-.350.......360.......370---.-----.-----..-----....----.380.......390.......400.......410.......420.......430.......440---.---.--......-.450.....--.--..--460.......470--------.--------.--------.....--480------.........490.......500....--.--..510.....-.-.520.-......530.......540....---.--..550..--.....560.......570-...-....580.......590.......600......-----------------.610.......620.......630.......--------640---......-----...650.......660.......670..--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTNPYPNLL
S
P
L
D
L
G
F
T
T
L
R
N
R
V
V
M-------G--SMHT
G
L
E
D
-
R
-
A
R
H
I
D
R
L
A
D
Y
F
A
E
RARG
G
V
G
L
I
I
TGGYAPN-RT
G
W
L
-
L
-
P
F
-
A
S
E
L
V
T
S
A
Q
A
R
-
R
H
R
R
I
T
R
A
V
HD
S
G
A
K
I
L
L
Q
I
L
HAGRYA-------------------YH------
P
-----------
L
----AVSASPI-KAP---I---------TPFRPRALSARG
V
E
A
T
I
A
D
F
A
R
C
A
Q
L
-------
A
R
DAGYD
G
V
E
I
MGSE
G
Y
-
L
-
L
N
Q
F
LAPRTNKRTDSWGGTPANRRRF
P
V
E
I
I
R
R
S
------RAAVGC
D
F
I
I
C
Y
RL
S
M
A
D
Y
V
-A-E---GQ
S
W
-
D
E
I
-----
V
A
L
A
TEVEGA
G
A
T
I
INSGFGWHEARV
P
T
I
--
V
TS--VPG
G
-
A
F
V
D
-
I
S
S
A
V
AEH
V
T
I
P
V
V
ASNRIN
M
P
Q
A
A
E
R
I
L
A
E
T
Q
V
R
L
I
S
MARPMLSDP
D
W
V
L
KAQSNR
V
D
E
I
N
T
C
I
S
C
N
Q
A
C
L
D
H
A
-
F
A
R
K
T
V
S
C
L
LNPRAGR
E
T
Q
L
V
L-----S-----P-----TR-----R
A
R
S
----
V
A
V
VGAGPA
G
L
A
T
A
A
N
A
AQRG
H
R
V
T
L
F
EANDFIGG
Q
F
D
M
A
RRIP
G
K
E
E
F
S
E
T
I
R
Y
F
S
T
I
L
A
K-----H---G--
V
E
V
R
LG-T
R
-
V
A
A
Q
EL--T--GY--D
E
V
V
LATGVAPRI--------P--------A--------IPGID--H--------
P
M
V
L
T
Y
A
E
A
I
TGVRPVG
R
T
V
A
V
V
GAG--G--IG
F
D
V
T
E
L
L
V-T-DSSPT-L
N
L
K
E
W
K
A
EWGVA
D
P
R
E
ARGALT---T--PLPAPPA--
R
E
V
Y
L
L
QRTKGPQGKRLG-KTT-G
W
V
H
R
ASLKAKGVHQLSGV
N
Y
E
QINDD
G
L
H
I
SF-----------------GPKRRR
P
Q
L
L
A
VD
N
V
V
V
CAGQE
P
V
R
D
L
E
S
E
L
--------
R
-----RHGINP-----HIIGG
A
A
V
A
A
E
L
D
A
K
R
A
I
K
Q
G
T
E
L
A
ARL--------------------
101
HHSearch
97.16
53%
-91
* C7 *
1PS9
8
FADH_ECOLI
A:
[1-671]
---
S
Y
P
S
L
F
A
P
L
D
L
G
F
T
T
L
K
N
R
V
L
M
-------
G
--
S
M
H
T
G
L
E
E
-
Y
-
P
D
G
A
E
R
L
A
A
F
Y
A
E
R
A
R
H
G
V
A
L
I
V
S
G
G
I
A
P
D
-
L
T
G
V
G
-
M
-
E
G
-
G
A
M
L
N
D
A
S
Q
I
P
-
H
H
R
T
I
T
E
A
V
H
Q
E
G
G
K
I
A
L
Q
I
L
H
T
G
R
Y
S
-------------------
Y
Q
------
P
-----------
H
----
L
V
A
P
S
A
L
-
Q
A
P
---
I
---------
N
R
F
V
P
H
E
L
S
H
E
E
I
L
Q
L
I
D
N
F
A
R
C
A
Q
L
-------
A
R
E
A
G
Y
D
G
V
E
V
M
G
S
E
G
Y
-
L
-
I
N
E
F
L
T
L
R
T
N
Q
R
S
D
Q
W
G
G
D
Y
R
N
R
M
R
F
A
V
E
V
V
R
A
V
------
R
E
R
V
G
N
D
F
I
I
I
Y
R
L
S
M
L
D
L
V
-
E
-
D
---
G
G
T
F
-
A
E
T
-----
V
E
L
A
Q
A
I
E
A
A
G
A
T
I
I
N
T
G
I
G
W
H
E
A
R
I
P
T
I
--
A
T
P
--
V
P
R
G
-
A
F
S
W
-
V
T
R
K
L
K
G
H
V
S
L
P
L
V
T
T
N
R
I
N
D
P
Q
V
A
D
D
I
L
S
R
G
D
A
D
M
V
S
M
A
R
P
F
L
A
D
A
E
L
L
S
K
A
Q
S
G
R
A
D
E
I
N
T
C
I
G
C
N
Q
A
C
L
D
Q
I
-
F
V
G
K
V
T
S
C
L
V
N
P
R
A
C
H
E
T
K
M
P
I
-----
L
-----
P
-----
A
V
-----
Q
K
K
N
----
L
A
V
V
G
A
G
P
A
G
L
A
F
A
I
N
A
A
A
R
G
H
Q
V
T
L
F
D
A
H
S
E
I
G
G
Q
F
N
I
A
K
Q
I
P
G
K
E
E
F
Y
E
T
L
R
Y
Y
R
R
M
I
E
V
-----
T
---
G
--
V
T
L
K
L
N
-
H
T
-
V
T
A
D
Q
L
--
Q
--
A
F
--
D
E
T
I
L
A
S
G
I
V
P
R
T
--------
P
--------
P
--------
I
D
G
I
D
--
H
--------
P
K
V
L
S
Y
L
D
V
L
R
D
K
A
P
V
G
N
K
V
A
I
I
G
C
G
--
G
--
I
G
F
D
T
A
M
Y
L
S
-
Q
-
P
G
E
S
T
S
Q
N
I
A
G
F
C
N
E
W
G
I
D
S
S
L
Q
Q
A
G
G
L
S
---
P
Q
G
M
Q
I
P
R
S
P
--
R
Q
I
V
M
L
Q
R
K
A
S
K
P
G
Q
G
L
G
-
K
T
T
-
G
W
I
H
R
T
T
L
L
S
R
G
V
K
M
I
P
G
V
S
Y
Q
K
I
D
D
D
G
L
H
V
V
I
--------------------
N
G
E
T
Q
V
L
A
V
D
N
V
V
I
C
A
G
Q
E
P
N
R
A
L
A
Q
P
L
--------
I
-----
D
S
G
K
T
V
-----
H
L
I
G
G
C
D
V
A
M
E
L
D
A
R
R
A
I
A
Q
G
T
R
L
A
L
E
I
--------------------
122
Fugue
96.91
53%
-90
- C7 -
1PS9
8
FADH_ECOLI
A:
[1-671]
---
S
Y
P
S
L
F
A
P
L
D
L
G
F
T
T
L
K
N
R
V
L
M
-------
G
--
S
M
H
T
G
L
E
E
-
Y
-
P
D
G
A
E
R
L
A
A
F
Y
A
E
R
A
R
H
G
V
A
L
I
V
S
G
G
I
A
P
D
-
L
T
G
V
G
-
M
-
E
G
-
G
A
M
L
N
D
A
S
Q
I
P
-
H
H
R
T
I
T
E
A
V
H
Q
E
G
G
K
I
A
L
Q
I
L
H
T
G
R
Y
S
-------------------
Y
Q
------
P
-----------
H
----
L
V
A
P
S
A
L
-
Q
A
P
---
I
---------
N
R
F
V
P
H
E
L
S
H
E
E
I
L
Q
L
I
D
N
F
A
R
C
A
Q
L
-------
A
R
E
A
G
Y
D
G
V
E
V
M
G
S
E
G
Y
-
L
-
I
N
E
F
L
T
L
R
T
N
Q
R
S
D
Q
W
G
G
D
Y
R
N
R
M
R
F
A
V
E
V
V
R
A
V
------
R
E
R
V
G
N
D
F
I
I
I
Y
R
L
S
M
L
D
L
V
-
E
-
D
---
G
G
T
F
-
A
E
T
-----
V
E
L
A
Q
A
I
E
A
A
G
A
T
I
I
N
T
G
I
G
W
H
E
A
R
I
P
T
I
--
A
T
P
--
V
P
R
G
-
A
F
S
W
-
V
T
R
K
L
K
G
H
V
S
L
P
L
V
T
T
N
R
I
N
D
P
Q
V
A
D
D
I
L
S
R
G
D
A
D
M
V
S
M
A
R
P
F
L
A
D
A
E
L
L
S
K
A
Q
S
G
R
A
D
E
I
N
T
C
I
G
C
N
Q
A
C
L
D
Q
I
-
F
V
G
K
V
T
S
C
L
V
N
P
R
A
C
H
E
T
K
M
P
I
-----
L
-----
P
-----
A
V
-----
Q
K
K
N
----
L
A
V
V
G
A
G
P
A
G
L
A
F
A
I
N
A
A
A
R
G
H
Q
V
T
L
F
D
A
H
S
E
I
G
G
Q
F
N
I
A
K
Q
I
P
G
K
E
E
F
Y
E
T
L
R
Y
Y
R
R
M
I
E
V
-----
T
---
G
--
V
T
L
K
L
N
-
H
T
-
V
T
A
D
Q
L
--
Q
--
A
F
--
D
E
T
I
L
A
S
G
I
V
P
R
T
--------
P
--------
P
--------
I
D
G
I
D
--
H
--------
P
K
V
L
S
Y
L
D
V
L
R
D
K
A
P
V
G
N
K
V
A
I
I
G
C
G
--
G
--
I
G
F
D
T
A
M
Y
L
S
Q
P
-
G
E
S
T
S
-
Q
N
I
A
G
F
C
N
E
W
G
I
D
S
S
L
Q
Q
A
G
G
L
S
---
P
--
Q
G
M
Q
I
P
R
SP
R
Q
I
V
M
L
Q
R
K
A
S
K
P
G
Q
G
L
G
-
K
T
T
-
G
W
I
H
R
T
T
L
L
S
R
G
V
K
M
I
P
G
V
S
Y
Q
K
I
D
D
D
G
L
H
V
V
I
-----------------
N
---
G
E
T
Q
V
L
A
V
D
N
V
V
I
C
A
G
Q
E
P
N
R
A
L
A
Q
P
L
--------
I
-----
D
S
G
K
T
V
-----
H
L
I
G
G
C
D
V
A
M
E
L
D
A
R
R
A
I
A
Q
G
T
R
L
A
L
E
I
--------------------
1
PsiBlast_PDB
96.64
52%
-91
- C7 -
1PS9
8
FADH_ECOLI
A:
[2-671]
----
Y
P
S
L
F
A
P
L
D
L
G
F
T
T
L
K
N
R
V
L
M
-------
G
--
S
M
H
T
G
L
E
E
-
Y
-
P
D
G
A
E
R
L
A
A
F
Y
A
E
R
A
R
H
G
V
A
L
I
V
S
G
G
I
A
P
D
-
L
T
G
V
G
-
M
-
E
G
-
G
A
M
L
N
D
A
S
Q
I
P
-
H
H
R
T
I
T
E
A
V
H
Q
E
G
G
K
I
A
L
Q
I
L
H
T
G
R
Y
S
-------------------
Y
Q
------
P
-----------
H
----
L
V
A
P
S
A
L
-
Q
A
P
---
I
---------
N
R
F
V
P
H
E
L
S
H
E
E
I
L
Q
L
I
D
N
F
A
R
C
A
Q
L
-------
A
R
E
A
G
Y
D
G
V
E
V
M
G
S
E
G
Y
-
L
-
I
N
E
F
L
T
L
R
T
N
Q
R
S
D
Q
W
G
G
D
Y
R
N
R
M
R
F
A
V
E
V
V
R
A
V
------
R
E
R
V
G
N
D
F
I
I
I
Y
R
L
S
M
L
D
L
V
-
E
-
D
---
G
G
T
F
-
A
E
T
-----
V
E
L
A
Q
A
I
E
A
A
G
A
T
I
I
N
T
G
I
G
W
H
E
A
R
I
P
T
I
--
A
T
P
--
V
P
R
G
-
A
F
S
W
-
V
T
R
K
L
K
G
H
V
S
L
P
L
V
T
T
N
R
I
N
D
P
Q
V
A
D
D
I
L
S
R
G
D
A
D
M
V
S
M
A
R
P
F
L
A
D
A
E
L
L
S
K
A
Q
S
G
R
A
D
E
I
N
T
C
I
G
C
N
Q
A
C
L
D
Q
I
-
F
V
G
K
V
T
S
C
L
V
N
P
R
A
C
H
E
T
K
M
P
I
-----
L
-----
P
-----
A
V
-----
Q
K
K
N
----
L
A
V
V
G
A
G
P
A
G
L
A
F
A
I
N
A
A
A
R
G
H
Q
V
T
L
F
D
A
H
S
E
I
G
G
Q
F
N
I
A
K
Q
I
P
G
K
E
E
F
Y
E
T
L
R
Y
Y
R
R
M
I
E
V
-----
T
---
G
--
V
T
L
K
L
N
-
H
T
-
V
T
A
D
Q
L
--
Q
--
A
F
--
D
E
T
I
L
A
S
G
I
V
P
R
T
--------
P
--------
P
--------
I
D
G
I
D
--
H
--------
P
K
V
L
S
Y
L
D
V
L
R
D
K
A
P
V
G
N
K
V
A
I
I
G
C
G
--
G
--
I
G
F
D
T
A
M
Y
L
S
-
Q
P
G
E
S
T
S
-
Q
N
I
A
G
F
C
N
E
W
G
I
D
S
S
L
Q
Q
A
G
G
L
S
PQ
G
M
--
Q
I
P
R
S
P
---
R
Q
I
V
M
L
Q
R
K
A
S
K
P
G
Q
G
L
G
-
K
T
T
-
G
W
I
H
R
T
T
L
L
S
R
G
V
K
M
I
P
G
V
S
Y
Q
K
I
D
D
D
G
L
H
V
V
I
-----------------
N
G
E
T
---
Q
V
L
A
V
D
N
V
V
I
C
A
G
Q
E
P
N
R
A
L
A
Q
P
L
--------
I
-----
D
S
G
K
T
V
-----
H
L
I
G
G
C
D
V
A
M
E
L
D
A
R
R
A
I
A
Q
G
T
R
L
A
L
E
I
--------------------
103
HHSearch
71.47
24%
-87
- C7 -
1O94
3
DHTM_METME
A:
[2-695]
R
D
P
K
H
D
I
L
F
E
P
I
Q
I
G
P
K
T
L
R
N
R
F
Y
Q
-------
V
--
P
H
C
I
G
A
G
S
-
D
-
K
--
P
G
F
Q
S
A
H
R
S
V
K
A
E
G
G
W
A
A
L
N
T
E
Y
C
S
I
N
-
P
E
S
D
D
T
H
-
R
L
-
S
A
R
I
W
D
E
G
D
V
R
-
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
A
-------------------
P
N
------
M
-----------
E
SR
A
T
P
R
G
P
S
Q
Y
-
A
S
E
---
F
E--------
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
Q
V
Q
Q
F
Y
V
D
A
A
K
R
-------
S
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
K
Y
G
G
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
------
K
H
A
V
G
S
D
C
A
I
A
T
R
F
G
V
D
T
V
Y
G
P
-
G
---
Q
I
E
A
E
V
D
G
-----
Q
K
F
V
E
M
A
D
S
-
L
V
D
M
W
D
I
T
I
G
D
I
A
E
W
G
E
D
A
GP
S
R
F
--
Y
Q
Q
G
-
H
T
I
P
-
W
V
K
L
V
K
Q
V
S
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
-
C
I
S
R
W
E
I
G
G
P
P
M
I
C
T
Q
N
A
T
A
G
E
E
Y
R
R
G
W
HPE
K
F
R
-----
Q
-----
T
K
-----
N
K
D
S
----
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
W
S
Y
H
R
D
Y
R
E
T
Q
I
T
K
-----
L
L
K
K
N
KE
S
Q
L
A
L
G
Q
K
P
-
M
T
A
D
D
V
L
Q
Y
--
G
A
--
D
K
V
I
I
A
T
G
A
R
W
N
T
DGTNCLTH
D
--------
P
--------
I
P
G
A
D
AS
L
--------
P
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
I
G
K
R
V
V
I
L
N
A
D
TY
F
--
M
A
P
S
L
A
E
K
L
A
-
T
-
A
----------------------------------------
G
--
H
E
V
T
I
V
S
G
V
-
H
L
A
-
N
Y
M
H
F
T
L
E
-
Y
P
N
M
M
R
R
L
H
E
L
H
V
E
E
L
G
D
H
F
C
S
R
I
E
P
G
R
M
E
I
Y
N
IWGDGSKRTYRGPGVSP
R
D
A
N
T
S
H
R
W
I
E
F
D
S
L
V
L
V
T
G
R
H
S
E
C
T
L
W
N
E
L
K
A
R
ESEWA
E
-----
N
D
I
K
G
I
-----
Y
L
I
G
D
A
E
--
A
P
R
L
I
A
D
A
T
F
T
G
H
R
V
A
R
E
I
--------------------
121
Fugue
69.53
25%
-78
- C7 -
3K30
3
?
A:
[7-690]
V
A
A
P
Y
D
V
L
F
E
P
V
Q
I
G
P
F
T
T
K
N
R
F
Y
Q
-------
V
--
P
H
C
N
G
M
G
Y
-
R
---
D
P
S
A
Q
A
S
M
R
K
I
K
A
E
G
G
W
S
A
V
C
T
E
Q
V
E
I
H
-
A
T
S
D
I
-
A
-
P
F
I
E
L
R
I
W
D
D
Q
D
L
P
-
A
L
K
R
I
A
D
A
I
H
E
G
G
G
L
A
G
I
E
L
A
H
N
G
M
N
A
-------------------
P
N
QLSR
E
T
P
-----------
L
----
G
P
G
H
L
P
V
A
P
D
T
---
I
---------
A
P
I
Q
A
R
A
M
T
K
Q
D
I
D
D
L
R
R
W
H
R
N
A
V
R
R
-------
S
I
E
A
G
Y
D
I
V
Y
V
Y
G
A
H
G
Y
S
G
-
V
H
H
F
L
S
K
R
Y
N
Q
R
T
D
E
Y
G
G
S
L
E
N
R
M
R
L
L
R
E
L
L
E
D
T
------
L
D
E
C
A
G
R
A
A
V
A
C
R
I
T
V
E
E
E
I
-
D
-
G
---
G
I
T
R
-
E
D
I
-----
E
G
V
L
R
E
L
-
G
E
L
P
D
L
W
D
F
A
M
G
S
W
E
G
D
S
V
T
---
S
R
F
--
A
P
E
G
-
R
Q
E
E
-
F
V
A
G
L
K
K
L
T
T
K
P
V
V
G
V
G
R
F
T
S
P
D
A
M
V
R
Q
I
K
A
G
I
L
D
L
I
G
A
A
R
P
S
I
A
D
P
F
L
P
N
K
I
R
D
G
R
L
N
L
I
R
E
C
I
G
C
N
-
I
C
V
S
G
D
-
L
T
M
S
P
I
R
C
T
Q
N
P
S
M
G
E
E
W
R
R
G
W
-----
H
-----
P
-----
E
R
IRAKE
S
D
A
R
----
V
L
V
V
G
A
G
P
S
G
L
E
A
A
R
A
L
G
V
R
G
Y
D
V
V
L
A
E
A
G
R
D
L
G
G
R
V
T
Q
E
S
A
L
P
G
L
S
A
W
G
R
V
K
E
Y
R
E
A
V
L
A
E
L----
P
---
N
--
V
E
I
Y
R
E
-
S
P
-
M
T
G
D
D
I
--
V
E
F
G
F
--
E
H
V
I
T
A
T
G
A
T
W
R
T
--------
D
GVARFHTT
A
--------
L
P
I
A
E
--
G
--------
M
Q
V
L
G
P
D
D
L
F
A
G
R
L
P
D
G
K
K
V
V
V
Y
D
D
D
--
H
YY
L
G
G
V
V
A
E
L
L
A
-
Q
-
K
G
------------------------------------------
Y
E
V
S
I
V
T
P
-
G
A
Q
V
S
S
W
T
N
-
N
T
F
E
V
N
R
I
Q
R
R
L
I
E
N
G
V
A
R
V
T
D
H
A
V
V
A
V
G
A
G
G
V
T
V
R
D
-----------------
T
Y
A
S
I
-
E
R
E
L
E
C
D
A
V
V
M
V
T
A
R
L
P
R
E
E
L
Y
L
D
L
--------
V
-----
A
R
R
D
A
G
EIA
S
V
R
G
I
G
D
A
W
--
A
P
G
T
I
A
A
A
V
W
S
G
R
R
A
A
E
E
F
DAVLPSNDEVP
F
R
R
E
V
T
QLA
102
HHSearch
68.85
24%
-75
- C7 -
3K30
3
?
A:
[8-670]
-
A
A
P
Y
D
V
L
F
E
P
V
Q
I
G
P
F
T
T
K
N
R
F
Y
Q
-------
V
--
P
H
C
N
G
M
G
Y
-
R
-
D
--
P
S
A
Q
A
S
M
R
K
I
K
A
E
G
G
W
S
A
V
C
T
E
Q
V
E
I
H
-
A
T
S
D
I
-
A
P
F
I
-
E
L
R
I
W
D
D
Q
D
L
P
-
A
L
K
R
I
A
D
A
I
H
E
G
G
G
L
A
G
I
E
L
A
H
N
G
M
N
A
-------------------
P
N
------
Q
LSR
E
-------
T
----
P
L
G
P
G
H
L
-
P
V
A
PDT
I
---------
A
P
I
Q
A
R
A
M
T
K
Q
D
I
D
D
L
R
R
W
H
R
N
A
V
R
R
-------
S
I
E
A
G
Y
D
I
V
Y
V
Y
G
A
H
G
Y
-
S
G
V
H
H
F
L
S
K
R
Y
N
Q
R
T
D
E
Y
G
G
S
L
E
N
R
M
R
L
L
R
E
L
L
E
D
T
------
L
D
E
C
A
G
R
A
A
V
A
C
R
I
T
V
E
E
E
I
-
D
-
G
---
G
I
T
R
-
E
D
I
-----
E
G
V
L
R
E
L
G
E
L
-
P
D
L
W
D
F
A
M
G
S
W
E
G
D
S
V
T
---
S
R
F
--
A
P
E
G
-
R
Q
E
E
-
F
V
A
G
L
K
K
L
T
T
K
P
V
V
G
V
G
R
F
T
S
P
D
A
M
V
R
Q
I
K
A
G
I
L
D
L
I
G
A
A
R
P
S
I
A
D
P
F
L
P
N
K
I
R
D
G
R
L
N
L
I
R
E
C
I
G
C
N
I
-
C
V
S
G
D
-
L
T
M
S
P
I
R
C
T
Q
N
P
S
M
G
E
E
W
R
R
G
W
-----
H
PERIR
A
-----
K
E
-----
S
D
A
R
----
V
L
V
V
G
A
G
P
S
G
L
E
A
A
R
A
L
G
V
R
G
Y
D
V
V
L
A
E
A
G
R
D
L
G
G
R
V
T
Q
E
S
A
L
P
G
L
S
A
W
G
R
V
K
E
Y
R
E
A
V
L
A
E
-----
L
P--
N
--
V
E
I
Y
R
E
-
S
P
-
M
T
G
D
D
I
V
E
F
--
G
F
--
E
H
V
I
T
A
T
G
A
T
W
R
T
--------
D
--------
G
--------
V
A
R
F
H
--
T
TALPIAEG
M
Q
V
L
G
P
D
D
L
F
A
G
R
L
P
D
G
K
K
V
V
V
Y
D
D
D
HY
Y
--
L
G
G
V
V
A
E
L
L
A
-
Q
-
K
----------------------------------------
G
--
Y
E
V
S
I
V
T
P
G
-
A
Q
V
S
S
W
T
N
N
T
F
E
-
V
N
R
I
Q
R
R
L
I
E
N
G
V
A
R
V
T
D
H
A
V
V
A
V
G
A
G
G
V
T
V
R
D
-----------------
T
-
Y
A
S
I
E
R
E
L
E
C
D
A
V
V
M
V
T
A
R
L
P
R
E
E
L
Y
L
D
L
--------
V
A
R
R
D
A
G
E
I
A
S
V
-----
R
G
I
G
D
A
W
--
A
P
G
T
I
A
A
A
V
W
S
G
R
R
A
A
E
E
F
--------------------
7
PsiBlast_PDB
62.89
27%
-75
- C6 -
3K30
3
?
A:
[10-528]
---
P
Y
D
V
L
F
E
P
V
Q
I
G
P
F
T
T
K
N
R
F
Y
Q
-------
V
--
P
H
C
N
G
M
G
----
Y
R
D
P
S
A
Q
A
S
M
R
K
I
K
A
E
G
G
W
S
A
V
C
T
E
Q
V
E
I
H
-
A
T
S
D
I
-
A
-
P
F
-
I
E
L
R
I
W
D
D
Q
D
L
P
A
L
K
R
I
A
D
A
I
H
E
G
G
G
L
A
G
I
E
L
A
H
N
G
M
N
A
-------------------
P
N
QLSR
E
T
P
-----------
L
----
G
P
G
H
L
P
V
--
A
P
DT-
I
---------
A
P
I
Q
A
R
A
M
T
K
Q
D
I
D
D
L
R
R
W
H
R
N
A
V
R
R
-------
S
I
E
A
G
Y
D
I
V
Y
V
Y
G
A
H
G
Y
-
S
G
V
H
H
F
L
S
K
R
Y
N
Q
R
T
D
E
Y
G
G
S
L
E
N
R
M
R
L
L
R
E
L
L
E
D
T
L
D
E
C
A
G
R
A
A
V
A
C
------
R
I
T
V
E
E
E
I
-
D
-
G
---
G
I
T
R
-
E
D
I
-----
E
G
V
L
R
E
L
-
G
E
L
P
D
L
W
D
F
A
M
G
S
W
E
G
---
D
S
--
V
T
S
RF
A
P
E
G
-
R
Q
E
E
-
F
V
A
G
L
K
K
L
T
T
K
P
V
V
G
V
G
R
F
T
S
P
D
A
M
V
R
Q
I
K
A
G
I
L
D
L
I
G
A
A
R
P
S
I
A
D
P
F
L
P
N
K
I
R
D
G
R
L
N
L
I
R
E
C
I
G
C
N
-
I
C
V
S
G
D
-
L
T
M
S
P
I
R
C
T
Q
N
P
S
M
G
E
E
W
R
R
G
W
-----
H
-----
P
-----
E
R
I----
R
A
K
E
SD
A
R
V
L
V
V
G
A
G
P
S
G
L
E
A
A
R
A
L
G
V
R
G
Y
D
V
V
L
A
E
A
G
R
D
L
G
G
R
V
T
Q
E
S
A
L
P
G
L
S
A
W
G
R
V
K
E
Y
R
E
A
V
L
A
E
L----
P
---
N
--
V
E
I
Y
R
E
-
S
P
-
M
T
G
D
D
I
--
V
E
F
G
F
--
E
H
V
I
T
A
T
G
A
T
W
R
T
--------
D
GVARFHTT
A
--------
L
P
I
A
E
--
G
--------
M
Q
V
L
G
P
D
D
L
F
A
G
R
L
P
D
G
K
K
V
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
60.73
28%
-89
- C6 -
5CPL
2
?
A:
[4-338]
-------
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
-------
P
--
P
M
C
Q
Y
M
A
E
-
D
-
G
L
I
N
D
W
H
Q
V
H
Y
A
S
M
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
-
P
E
G
R
I
-
T
-
P
G
-
C
A
G
I
W
S
D
A
H
A
Q
-
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
K
A
SANRPWEGDDHIGADDAR
G
W
E
------
T
-----------
I
----
A
P
S
A
I
A
F
-
G
A
H
---
L
----------
P
N
V
P
R
A
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
-------
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
Y
-
L
-
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
------
R
E
V
W
P
E
N
L
P
L
T
A
R
F
G
V
L
E
Y
D
-
G
R
D
---
E
Q
T
L
-
E
E
S
-----
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
---
T
I
P
E
----
T
N
--
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
H
W
A
Y
F
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
60.48
26%
-74
- C6 -
1DJQ
3
DHTM_METME
A:
[9-536]
-------
L
F
E
P
I
Q
I
G
P
K
T
L
R
N
R
F
Y
Q
V
P
HAIGA
G
--
S
D
K
P
G
F
Q
S
-
A
-
H
R
S
V
---------
K
A
E
G
G
W
A
A
L
N
T
E
Y
C
S
I
N
P
E
S
D
D
T
-
H
-
R
L
-
S
A
R
I
W
D
E
G
D
V
R
-
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
A
---------------------------
P
-----------
N
----
M
E
S
R
A
T
P
-
R
G
P
---
S
---------
Q
Y
A
S
E
F
E
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
K
Y
G
G
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
------
K
H
A
V
G
S
D
C
A
I
A
T
R
F
G
V
D
T
V
Y
-
G
-
P
---
G
Q
I
E
-
A
E
V
D
G
Q
K
F
V
E
M
A
D
S
L
V
D
M
W
D
I
T
I
G
D
I
A
E
W
G
E
D
A
G
P
S
R
--
F
Y
Q
--
Q
--
G
-
H
T
I
P
-
W
V
K
L
V
K
Q
V
S
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
C
I
S
R
W
E
-
I
G
G
P
P
M
I
C
T
Q
N
A
T
A
G
E
E
Y
R
R
G
W
-----
H
-----
P
E
K
F
R
Q
T
K
-----
N
K
D
S
----
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
W
S
Y
H
R
D
Y
R
E
T
Q
I
T
K
L
L
K
K
N
K
---
E
--
S
Q
L
A
L
G
-
Q
K
P
M
T
A
D
D
V
--
L
--
Q
Y
GA
D
K
V
I
I
A
T
G
A
R
W
N
T
--------
D
--------
G
TNCLTHDP
I
P
G
A
D
--
A
SL------
P
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
I
G
K
R
V
V
I
L
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
60.41
26%
-71
- C6 -
1DJN
3
DHTM_METME
A:
[9-536]
-------
L
F
E
P
I
Q
I
G
P
K
T
L
R
N
R
F
Y
Q
V
P
HCIGA
G
--
S
D
K
P
G
F
Q
S
-
A
-
H
R
S
V
---------
K
A
E
G
G
W
A
A
L
N
T
E
Y
C
S
I
N
P
E
S
D
D
T
-
H
-
R
L
-
S
A
R
I
W
D
E
G
D
V
R
-
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
A
---------------------------
P
-----------
N
----
M
E
S
R
A
T
P
-
R
G
P
---
S
---------
Q
Y
A
S
E
F
E
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
K
Y
G
G
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
------
K
H
A
V
G
S
D
C
A
I
A
T
R
F
G
V
D
T
V
Y
-
G
-
P
---
G
Q
I
E
-
A
E
V
D
G
Q
K
F
V
E
M
A
D
S
L
V
D
M
W
D
I
T
I
G
D
I
A
E
W
G
E
D
A
G
P
S
R
--
F
Y
Q
--
Q
--
G
-
H
T
I
P
-
W
V
K
L
V
K
Q
V
S
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
C
I
S
R
W
E
-
I
G
G
P
P
M
I
C
T
Q
N
A
T
A
G
E
E
Y
R
R
G
W
-----
H
-----
P
E
K
F
R
Q
T
K
-----
N
K
D
S
----
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
W
S
Y
H
R
D
Y
R
E
T
Q
I
T
K
L
L
K
K
N
K
---
E
--
S
Q
L
A
L
G
-
Q
K
P
M
T
A
D
D
V
--
L
--
Q
Y
GA
D
K
V
I
I
A
T
G
A
R
W
N
T
--------
D
--------
G
TNCLTHDP
I
P
G
A
D
--
A
SL------
P
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
I
G
K
R
V
V
I
L
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
60.37
26%
-71
- C6 -
2TMD
3
DHTM_METME
A:
[9-536]
-------
L
F
E
P
I
Q
I
G
P
K
T
L
R
N
R
F
Y
Q
V
P
HCIGA
G
--
S
D
K
P
G
F
Q
S
-
A
-
H
R
S
V
---------
K
A
E
G
G
W
A
A
L
N
T
E
Y
C
S
I
N
P
E
S
D
D
T
-
H
-
R
L
-
S
A
R
I
W
D
E
G
D
V
R
-
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
A
---------------------------
P
-----------
N
----
M
E
S
R
A
T
P
-
R
G
P
---
S
---------
Q
Y
A
S
E
F
E
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
K
Y
G
G
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
------
K
H
A
V
G
S
D
C
A
I
A
T
R
F
G
V
D
T
V
Y
-
G
-
P
---
G
Q
I
E
-
A
E
V
D
G
Q
K
F
V
E
M
A
D
S
L
V
D
M
W
D
I
T
I
G
D
I
A
E
W
G
E
D
A
G
P
S
R
--
F
Y
Q
--
Q
--
G
-
H
T
I
P
-
W
V
K
L
V
K
Q
V
S
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
C
I
S
R
W
E
-
I
G
G
P
P
M
I
C
T
Q
N
A
T
A
G
E
E
Y
R
R
G
W
-----
H
-----
P
E
K
F
R
Q
T
K
-----
N
K
D
S
----
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
W
S
Y
H
R
D
Y
R
E
T
Q
I
T
K
L
L
K
K
N
K
---
E
--
S
Q
L
A
L
G
-
Q
K
P
M
T
A
D
D
V
--
L
--
Q
Y
GA
D
K
V
I
I
A
T
G
A
R
W
N
T
--------
D
--------
G
TNCLTHDP
I
P
G
A
D
--
A
SL------
P
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
I
G
K
R
V
V
I
L
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
60.16
29%
-82
- C6 -
3HGJ
2
?
A:
[2-336]
-----
A
L
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
-------
S
--
P
M
C
Q
Y
S
A
T
L
E
-
G
E
V
T
D
W
H
L
L
H
Y
P
T
R
A
L
G
G
V
G
L
I
L
V
E
A
T
A
V
E
-
P
L
G
R
I
-
S
-
P
Y
-
D
L
G
I
W
S
E
D
H
L
P
-
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
K
A
-------------------
G
T
------
A
RPWEGGKPLGW
R
----
V
V
G
P
S
P
I
-
P
F
D
---
E
---------
G
Y
P
V
P
E
P
L
D
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
-------
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
-
L
-
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
------
R
E
V
V
P
R
E
L
P
L
F
V
R
V
S
A
T
D
W
G
-
E
-
G
---
G
W
S
L
-
E
D
T
-----
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
G
V
V
L
R
V
R
-----
I
P
--
L
A
P
G
-
F
Q
V
P
-
F
A
D
A
V
R
K
R
V
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
Y
F
P
L
R
A
A
K
A
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
60.09
26%
-72
- C6 -
1O94
3
DHTM_METME
A:
[9-536]
-------
L
F
E
P
I
Q
I
G
P
K
T
L
R
N
R
F
Y
Q
V
P
HCIGA
G
--
S
D
K
P
G
F
Q
S
-
A
-
H
R
S
V
---------
K
A
E
G
G
W
A
A
L
N
T
E
Y
C
S
I
N
P
E
S
D
D
T
-
H
-
R
L
-
S
A
R
I
W
D
E
G
D
V
R
-
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
A
---------------------------
P
-----------
N
----
M
E
S
R
A
T
P
-
R
G
P
---
S
---------
Q
Y
A
S
E
F
E
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
K
Y
G
G
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
------
K
H
A
V
G
S
D
C
A
I
A
T
R
F
G
V
D
T
V
Y
-
G
-
P
---
G
Q
I
E
-
A
E
V
D
G
Q
K
F
V
E
M
A
D
S
L
V
D
M
W
D
I
T
I
G
D
I
A
E
W
G
E
D
A
G
P
S
R
--
F
Y
Q
--
Q
--
G
-
H
T
I
P
-
W
V
K
L
V
K
Q
V
S
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
C
I
S
R
W
E
-
I
G
G
P
P
M
I
C
T
Q
N
A
T
A
G
E
E
Y
R
R
G
W
-----
H
-----
P
E
K
F
R
Q
T
K
-----
N
K
D
S
----
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
W
S
Y
H
R
D
Y
R
E
T
Q
I
T
K
L
L
K
K
N
K
---
E
--
S
Q
L
A
L
G
-
Q
K
P
M
T
A
D
D
V
--
L
--
Q
Y
GA
D
K
V
I
I
A
T
G
A
R
W
N
T
--------
D
--------
G
TNCLTHDP
I
P
G
A
D
--
A
SL------
P
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
I
G
K
R
V
V
I
L
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
60.08
28%
-88
- C6 -
5CPM
2
?
A:
[4-338]
-------
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
-------
P
--
P
M
C
Q
Y
M
A
E
-
D
-
G
L
I
N
D
W
H
Q
V
H
Y
A
S
M
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
-
P
E
G
R
I
-
T
-
P
G
-
C
A
G
I
W
S
D
A
H
A
Q
-
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
K
A
SANRPWEGDDHIGADDAR
G
W
E
------
T
-----------
I
----
A
P
S
A
I
A
F
-
G
A
H
---
L
----------
P
N
V
P
R
A
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
-------
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
Y
-
L
-
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
------
R
E
V
W
P
E
N
L
P
L
T
A
R
F
G
V
L
E
Y
D
-
G
R
D
---
E
Q
T
L
-
E
E
S
-----
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
---
T
I
P
E
----
T
N
--
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
H
W
A
Y
F
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
59.62
28%
-87
- C6 -
5CPO
2
?
A:
[4-338]
-------
L
F
E
P
Y
T
L
K
D
V
T
L
R
N
R
I
A
I
-------
P
--
P
M
C
Q
Y
M
A
E
-
D
-
G
L
I
N
D
W
H
Q
V
H
Y
A
S
M
A
R
G
G
A
G
L
L
V
V
E
A
T
A
V
A
-
P
E
G
R
I
-
T
-
P
G
-
C
A
G
I
W
S
D
A
H
A
Q
-
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
K
A
SANRPWEGDDHIGADDAR
G
W
E
------
T
-----------
I
----
A
P
S
A
I
A
F
-
G
A
H
---
L
----------
P
N
V
P
R
A
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
-------
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
Y
-
L
-
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
------
R
E
V
W
P
E
N
L
P
L
T
A
R
F
G
V
L
E
Y
D
-
G
R
D
---
E
Q
T
L
-
E
E
S
-----
I
E
L
A
R
R
F
K
A
G
G
L
D
L
L
S
V
S
V
G
F
---
T
I
P
E
----
T
N
--
I
P
W
G
P
A
F
M
G
P
I
A
E
R
V
R
R
E
A
K
L
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
Q
A
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
H
W
A
Y
F
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
59.38
26%
-75
- C6 -
1O95
3
DHTM_METME
A:
[9-536]
-------
L
F
E
P
I
Q
I
G
P
K
T
L
R
N
R
F
Y
Q
V
P
HCIGA
G
--
S
D
K
P
G
F
Q
S
-
A
-
H
R
S
V
---------
K
A
E
G
G
W
A
A
L
N
T
E
Y
C
S
I
N
P
E
S
D
D
T
-
H
-
R
L
-
S
A
R
I
W
D
E
G
D
V
R
-
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
A
---------------------------
P
-----------
N
----
M
E
S
R
A
T
P
-
R
G
P
---
S
---------
Q
Y
A
S
E
F
E
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
K
Y
G
G
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
------
K
H
A
V
G
S
D
C
A
I
A
T
R
F
G
V
D
T
V
Y
-
G
-
P
---
G
Q
I
E
-
A
E
V
D
G
Q
K
F
V
E
M
A
D
S
L
V
D
M
W
D
I
T
I
G
D
I
A
E
W
G
E
D
A
G
P
S
R
--
F
Y
Q
--
Q
--
G
-
H
T
I
P
-
W
V
K
L
V
K
Q
V
S
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
C
I
S
R
W
E
-
I
G
G
P
P
M
I
C
T
Q
N
A
T
A
G
E
E
Y
R
R
G
W
-----
H
-----
P
EKFRQ
T
K
-----
N
K
D
S
----
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
W
S
Y
H
R
D
Y
R
E
T
Q
I
T
K
L
L
K
K
N
K
---
E
--
S
Q
L
A
L
G
-
Q
K
P
M
T
A
D
D
V
--
L
--
Q
Y
GA
D
K
V
I
I
A
T
G
A
R
W
N
T
--------
D
--------
G
TNCLTHDP
I
P
G
A
D
--
A
SL------
P
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
I
G
K
R
V
V
I
L
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
59.25
29%
-82
- C6 -
3KRU
2
?
A:
[2-325]
-----
S
I
L
H
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
-------
S
--
P
M
C
M
Y
S
A
S
T
D
-
G
M
P
N
D
W
H
I
V
H
Y
A
T
R
A
I
G
G
V
G
L
I
M
Q
E
A
T
A
V
E
-
S
R
G
R
I
-
T
-
D
H
-
D
L
G
I
W
N
D
E
Q
V
K
-
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
K
C
-------------------
N
I
------
S
YE---------
D
----
V
V
G
P
S
P
I
-
K
A
G
---
D
---------
R
Y
K
L
P
R
E
L
S
V
E
E
I
K
S
I
V
K
A
F
G
E
A
A
K
R
-------
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
-
L
-
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
------
R
K
N
W
P
E
N
K
P
I
F
V
R
V
S
A
D
D
Y
M
-
E
-
G
---
G
I
N
I
-
D
M
M
-----
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
L
N
V
D
------
I
N
--
L
Y
P
G
-
Y
Q
V
K
-
Y
A
E
T
I
K
K
R
C
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
V
L
H
T
Y
T
S
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
59.21
27%
-84
- C6 -
4AB4
8
?
A:
[2-327]
-----
T
T
L
F
D
P
I
K
L
G
D
L
Q
L
P
N
R
I
I
M
-------
A
--
P
L
T
R
C
R
A
D
-
E
G
R
V
P
N
A
L
M
A
E
Y
Y
V
Q
R
A
S
--
A
G
L
I
L
S
E
A
T
S
V
S
-
P
M
G
V
G
-
Y
-
P
D
-
T
P
G
I
W
N
D
E
Q
V
R
-
G
W
N
N
V
T
K
A
V
H
A
A
G
G
R
I
F
L
Q
L
W
H
V
G
R
I
S
-------------------
H
P
------
S
YLNGE------
L
----
P
V
A
P
S
A
I
-
Q
P
K
---
G
HVSLVRPLS
D
Y
P
T
P
R
A
L
E
T
E
E
I
N
D
I
V
E
A
Y
R
S
G
A
E
N
-------
A
K
A
A
G
F
D
G
V
E
I
H
G
A
N
G
Y
-
L
-
L
D
Q
F
L
Q
S
S
T
N
Q
R
T
D
R
Y
G
G
S
L
E
N
R
A
R
L
L
L
E
V
T
D
A
A
------
I
E
V
W
G
A
-
Q
R
V
G
V
H
L
A
P
R
A
D
A
-
H
-
D
MGD
A
D
R
A
-
E
T
F
-----
T
Y
V
A
R
E
L
G
K
R
G
I
A
F
I
C
S
R
E
R
E
A
D
--------------------
D
S
-
I
G
P
L
I
K
E
A
F
G
G
P
Y
I
V
N
E
R
F
D
-
K
A
S
A
N
A
A
L
A
S
G
K
A
D
A
V
A
F
G
V
P
F
I
A
N
P
D
L
P
A
R
L
A
A
D
A
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
59.16
29%
-86
- C6 -
1Z41
3
NAMA_BACSU
A:
[4-314]
------
K
L
F
T
P
I
T
I
K
D
M
T
L
K
N
R
I
V
M
-------
S
PM
C
M
Y
S
S
H
E
K
-
D
-
G
K
L
T
P
F
H
M
A
H
Y
I
S
R
A
I
G
Q
V
G
L
I
I
V
E
A
S
A
V
N
-
P
Q
G
R
I
-
T
-
D
Q
-
D
L
G
I
W
S
D
E
H
I
E
-
G
F
A
K
L
T
E
Q
V
K
E
Q
G
S
K
I
G
I
Q
L
A
H
A
G
R
K
A
ELE
G
D
I
-------------
F
A
------
P
-----------
S
----
A
I
A
F
D
E
Q
-
S
A
T
-----------------
P
V
E
M
S
A
E
K
V
K
E
T
V
Q
E
F
K
Q
A
A
A
R
-------
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
-
L
-
I
H
E
F
L
S
P
L
S
N
H
R
T
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
R
E
I
I
D
E
V
------
K
Q
V
--
W
D
G
P
L
F
V
R
V
S
A
S
D
Y
T
-
D
-
K
---
G
L
D
I
-
A
D
H
-----
I
G
F
A
K
W
M
K
E
Q
G
V
D
L
I
D
C
S
S
G
---
A
L
V
H
A
D
--
I
N
V
--
F
P
G
Y
-
Q
-
V
S
-
F
A
E
K
I
R
E
Q
A
D
M
A
T
G
A
V
G
M
I
T
D
G
S
M
A
E
E
I
L
Q
N
G
R
A
D
L
I
F
I
G
R
E
L
L
R
D
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.02
29%
-87
- C6 -
1Z42
3
NAMA_BACSU
A:
[4-314]
------
K
L
F
T
P
I
T
I
K
D
M
T
L
K
N
R
I
V
M
-------
S
PM
C
M
Y
S
S
H
E
K
-
D
-
G
K
L
T
P
F
H
M
A
H
Y
I
S
R
A
I
G
Q
V
G
L
I
I
V
E
A
S
A
V
N
-
P
Q
G
R
I
-
T
-
D
Q
-
D
L
G
I
W
S
D
E
H
I
E
-
G
F
A
K
L
T
E
Q
V
K
E
Q
G
S
K
I
G
I
Q
L
A
H
A
G
R
K
A
ELE
G
D
I
-------------
F
A
------
P
-----------
S
----
A
I
A
F
D
E
Q
-
S
A
T
-----------------
P
V
E
M
S
A
E
K
V
K
E
T
V
Q
E
F
K
Q
A
A
A
R
-------
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
-
L
-
I
H
E
F
L
S
P
L
S
N
H
R
T
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
R
E
I
I
D
E
V
------
K
Q
V
--
W
D
G
P
L
F
V
R
V
S
A
S
D
Y
T
-
D
-
K
---
G
L
D
I
-
A
D
H
-----
I
G
F
A
K
W
M
K
E
Q
G
V
D
L
I
D
C
S
S
G
---
A
L
V
H
A
D
--
I
N
V
--
F
P
G
Y
-
Q
-
V
S
-
F
A
E
K
I
R
E
Q
A
D
M
A
T
G
A
V
G
M
I
T
D
G
S
M
A
E
E
I
L
Q
N
G
R
A
D
L
I
F
I
G
R
E
L
L
R
D
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------