@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1188: (2016-04-29 )
MAGWFAHTLRPAMLAAGRSDRLGRIVERSPLTRGVVRRFVPGDTLDDVVDIVTALRDSGRYLSIDYLGENVTDADDAAAAVRAYLGLLDVLGRRGDIACDGVRPLEVSLKLSALGQALDRDGQKIALDNARAICERAERVGAWVTVDAEDHTTTDSTLSISGDLRVDFPWLGTVVQAYLRRTLADCAELAAVGARVRLCKGAYDEPASVAYRDAAQVTDSYLRCLRVLTAGRGYPMVATHDPVIIAAVPGITRESGRSQGDFEYQMLYGVRDDEQRRLTGAGNHVRVYVPFGTRWYGYFLRRLAERPANLAFFLRALTDRRRARGCAER
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------.........10.........20......-.--.-30.....--------..--------.40........50........60........70........80........90-----------..----......100...-.....110..---.---....120---.....-.-..----130........140.......150.......160....---.-----.--.---170.........180------....--------...190----.------....---....-------200.-.....-----------.210-.----------.----------..---------...---220.-......230-..--.---.....240.......250.......260.....---..270.......280----.------.--...--....290--.--.--.....300....-...310.......320.......------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------MAG
W
F
A
H
T
L
R
-
P
A
M
L
AAGR
S
D
R
L
G
R
I
V
E
-R--S-PL
T
R
G
V
V
--------
R
R
--------FVPGD
T
L
D
D
V
V
D
I
V
T
A
L
RDSG
R
Y
L
S
I
D
YLGENVTD
A
D
D
A
A
A
A
V
R
A
Y
L
G
L
L
D
V
L-----------GR----RGDIACD-G
V
R
P
-
L
E
V
S
L
K
L
S
A
L
---
G
---
Q
A
L
DRD----G
Q
K
I
A-L-D
N
----
A
R
-
A
I
C
E
R
A
E
RVG
A
W
V
T
VDAEDHTTTD
S
T
L
S
ISG
D
L
R
V
---D-----F--
P
---
W
--
L
G
T
V
V
Q
A
Y
L
R
R
T
------
L
A
D
C
--------
A
E
L
A
------
A
------
V
G
A
R
---
V
RLC-------KGAY-DEP
A
S
-----------
V
A
Y
R
-
D
----------
A
----------
A
Q
---------
V
T
D
---
S
Y
L
R
-
C
L
R
V
L
TAG--RG--
Y
---
P
M
VATHD
P
V
I
I
A
AVPGITRESGRSQGD
F
E
Y
Q
M
L
---YGVRDDEQRRLTG------A------G--
N
H
V
--
R
V
Y
VPFG--
T
--
R
--
W
Y
G
Y
F
L
R
R
L
A
ER-P
A
N
L
A
F
F
L
R
A
L
T
D
R
R
R
ARGCAER------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
94.94
39%
-103
* C6 *
2G37
3
?
B:
[49-314]
------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
L
V
--------
R
R
--------
Y
V
A
G
E
T
L
E
E
A
L
K
A
A
E
A
L
E
R
E
G
V
H
A
I
L
D
L
L
G
E
M
V
R
T
E
E
E
A
R
A
F
Q
R
G
L
L
E
L
V
W
A
L
-----------
A
G
----
K
P
--------
W
P
-
K
Y
I
S
L
K
L
T
Q
L
---
G
---
L
D
L
S
E
D
-------
L
A
-
L
-
A
L
----
L
R
-
E
V
L
R
E
A
E
P
R
G
V
F
V
R
L
D
M
E
D
S
P
R
V
E
A
T
L
R
L
Y
R
A
L
R
E
---
E
G----
F
--
S
---
Q
--
V
G
I
V
L
Q
S
Y
L
Y
R
T
------
E
K
D
L
--------
L
D
L
L
------
P
------
Y
R
P
N
---
L
R
L
V
-------
K
G
A
Y
-
R
E
P
K
E
-----------
V
A
F
P
-
D
----------
K
----------
R
L
---------
I
D
A
---
E
Y
L
H
-
L
G
K
L
A
L
K
E
--
G
L
--
Y
---
V
A
F
A
T
H
D
P
R
I
I
A
E
L
K
R
Y
T
E
A
M
G
I
P
R
S
R
F
E
F
Q
F
L
---
Y
G
V
R
P
E
E
Q
R
R
L
A
R
------
E
------
G
--
Y
T
V
--
R
A
Y
V
P
Y
G
--
R
--
D
--
W
Y
P
Y
L
T
R
R
I
A
E
R
-
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
94.41
39%
-104
- C6 -
2G37
3
?
A:
[49-316]
------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
L
V
--------
R
R
--------
Y
V
A
G
E
T
L
E
E
A
L
K
A
A
E
A
L
E
R
E
G
V
H
A
I
L
D
L
L
G
E
M
V
R
T
E
E
E
A
R
A
F
Q
R
G
L
L
E
L
V
W
A
L
-----------
A
G
----
K
P
--------
W
P
-
K
Y
I
S
L
K
L
T
Q
L
---
G
---
L
D
L
S
E
D
-------
L
A
-
L
-
A
L
----
L
R
-
E
V
L
R
E
A
E
P
R
G
V
F
V
R
L
D
M
E
D
S
P
R
V
E
A
T
L
R
L
Y
R
A
L
R
E
---
E
G----
F
--
S
---
Q
--
V
G
I
V
L
Q
S
Y
L
Y
R
T
------
E
K
D
L
--------
L
D
L
L
------
P
------
Y
R
P
N
---
L
R
L
V
-------
K
G
A
Y
-
R
E
P
K
E
-----------
V
A
F
P
-
D
----------
K
----------
R
L
---------
I
D
A
---
E
Y
L
H
-
L
G
K
L
A
L
K
E
--
G
L
--
Y
---
V
A
F
A
T
H
D
P
R
I
I
A
E
L
K
R
Y
T
E
A
M
G
I
P
R
S
R
F
E
F
Q
F
L
---
Y
G
V
R
P
E
E
Q
R
R
L
A
R
------
E
------
G
--
Y
T
V
--
R
A
Y
V
P
Y
G
--
R
--
D
--
W
Y
P
Y
L
T
R
R
I
A
E
R
-
P
E
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
91.56
27%
-91
- C6 -
3E2Q
4
PUTA_ECOLI
A:
[155-485]
-----------------------------------------------------------------------------------------------------------------------------------
G
E
P
L
I
R
K
G
V
D
------
M
A
M
R
L
M
G
--------
E
Q
--------
F
V
T
G
E
T
I
A
E
A
L
A
N
A
R
K
L
E
E
K
G
F
R
Y
S
Y
D
M
L
G
E
A
A
L
T
A
A
D
A
Q
A
Y
M
V
S
Y
Q
Q
A
I
H
A
I
-----------
G
K
----
A
S
N
-
G
R
G
-
I
Y
E
G
-
P
G
I
S
I
K
L
S
A
L
---
H
---
P
R
Y
S
R
A
Q
Y
D
R
V
M
E
E
L
-
Y
-
P
R
----
L
K
-
S
L
T
L
L
A
R
Q
Y
D
I
G
I
N
I
D
A
E
E
S
D
R
L
E
I
S
L
D
L
L
E
K
L
C
F
---
E
PELAG
W
--
N
---
G
--
I
G
F
V
I
Q
A
Y
Q
K
R
C
------
P
L
V
I
--------
D
Y
L
I
D
L
A
T
R
S
R
------
R
R
L
M
---
I
R
L
V
-------
K
G
A
Y
-
W
D
S
E
I
K
R
A
Q
M
D
GLEGY
P
V
Y
T
-
R
----------
K
----------
V
Y
---------
T
D
V
---
S
Y
L
A
-
C
A
K
K
L
L
A
V
--
P
N
LI
Y
---
P
Q
F
A
T
H
N
A
H
T
L
A
A
I
Y
Q
L
A
G
Q
-
N
Y
Y
P
G
Q
Y
E
F
Q
C
L
---
H
G
M
G
E
P
L
Y
E
Q
V
T
G
KVADGK
L
------
N
--
R
P
C
--
R
I
S
A
P
V
G
--
T
--
H
ET
L
L
A
Y
L
V
R
R
L
L
E
N
-
G
A
N
T
S
F
V
N
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.13
27%
-94
- C6 -
4NMD
4
?
A:
[116-446]
--------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
--------
R
Q
--------
F
I
V
G
E
T
T
K
E
A
V
K
N
L
E
K
L
R
K
D
G
F
A
A
V
V
D
V
L
G
E
A
T
L
S
E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
QGSWKGLP
G
K
----
G
G
D
P
G
L
D
W
G
H
A
P
K
V
N
I
A
V
K
P
T
A
L
F
CL
A
---
N
P
Q
D
F
E
----
G
S
V
V
A
I
L
-
D
R
----
M
R
-
R
I
F
K
K
V
M
E
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
R
R
L
K
L
E
Y
R
D
-----
Y
--
P
---
H
--
L
G
I
V
L
Q
A
Y
L
K
D
N
------
D
K
D
L
--------
D
D
L
L
------
A
W
A
K
E
H
K
V
Q
I
S
---
V
R
L
V
-------
K
G
A
Y
-
W
D
Y
E
T
-----------
V
K
A
K
-
Q
N
DWEVPVWTI
K
----------
A
E
---------
S
D
A
---
A
Y
E
R
-
Q
A
R
K
I
L
E
N
--
H
Q
I
C
H
---
F
A
C
A
S
H
N
I
R
T
I
S
A
V
M
E
M
A
R
E
L
N
V
P
E
D
R
Y
E
F
Q
V
L
---
Y
G
M
A
E
P
V
R
K
G
I
L
K
------
V
------
A
--
G
R
I
--
R
L
Y
A
P
Y
G
--
N
--
M
V
P
G
M
G
Y
L
V
R
R
L
L
E
N
-
T
A
N
E
S
F
L
R
Q
S
F
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
90.06
39%
-92
- C6 -
4H6Q
2
?
C:
[31-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
A
--------
E
R
--------
F
V
A
G
E
S
I
E
S
A
I
Q
A
V
Q
A
L
E
R
D
G
I
A
G
N
L
D
L
L
G
E
F
I
----
D
S
P
A
K
C
T
E
F
A
D
--
D
V
I
-----------
K
L
----
I
E
A
A
H
A
A
-
G
I
K
P
-
Y
-
V
S
I
K
L
S
S
V
---
G
---
Q
G
K
D
E
N
----
G
E
D
L
G
-
L
-
T
N
----
A
R
-
R
I
I
A
K
A
K
E
Y
G
G
F
I
C
L
D
M
E
D
H
T
R
V
D
V
T
L
E
Q
F
R
T
L
V
G
---
E
-----
F
GA
E
---
H
--
V
G
T
V
L
Q
S
Y
L
Y
R
S
------
L
G
D
R
--------
A
S
L
D
------
D
------
L
R
P
N
---
I
R
M
V
-------
K
G
A
Y
-
L
E
P
A
T
-----------
V
A
Y
P
-
D
----------
K
----------
A
D
---------
V
D
Q
---
N
Y
R
R
L
V
F
Q
H
L
K
A
G
---
N
--
Y
---
T
N
V
A
T
H
D
E
R
I
I
D
D
V
K
R
F
V
L
A
H
G
I
G
K
D
A
F
E
F
Q
M
L
---
Y
G
I
R
R
D
L
Q
K
Q
L
A
A
------
E
------
G
--
Y
R
V
--
R
V
Y
L
P
Y
G
--
R
--
D
--
W
Y
A
Y
F
S
R
R
I
A
E
T
-
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
89.91
27%
-91
- C6 -
4NMB
2
?
A:
[116-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
--------
R
Q
--------
F
I
V
G
E
T
T
K
E
A
V
K
N
L
E
K
L
R
K
D
G
F
A
A
V
V
D
V
L
G
E
A
T
L
S
E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
QGSWKGLP
G
K
----
G
G
D
P
G
L
D
W
G
H
A
P
K
V
N
I
A
V
K
P
T
A
L
F
CL
A
---
N
P
Q
D
F
E
----
G
S
V
V
A
I
L
-
D
R
----
M
R
-
R
I
F
K
K
V
M
E
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
R
R
L
K
L
E
Y
R
D
-----
Y
--
P
---
H
--
L
G
I
V
L
Q
A
Y
L
K
D
N
------
D
K
D
L
--------
D
D
L
L
------
A
W
A
K
E
H
K
V
Q
I
S
---
V
R
L
V
-------
K
G
A
Y
-
W
D
Y
E
T
-----------
V
K
A
K
-
Q
N
DWEVPVWTI
K
----------
A
E
---------
S
D
A
---
A
Y
E
R
-
Q
A
R
K
I
L
E
N
--
H
Q
I
C
H
---
F
A
C
A
S
H
N
I
R
T
I
S
A
V
M
E
M
A
R
E
L
N
V
P
E
D
R
Y
E
F
Q
V
L
---
Y
G
M
A
E
P
V
R
K
G
I
L
K
------
V
------
A
--
G
R
I
--
R
L
Y
A
P
Y
G
--
N
--
M
VP
G
M
G
Y
L
V
R
R
L
L
E
N
-
T
A
N
E
S
F
L
R
Q
S
F
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.74
39%
-94
- C6 -
4H6Q
3
?
A:
[31-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
A
--------
E
R
--------
F
V
A
G
E
S
I
E
S
A
I
Q
A
V
Q
A
L
E
R
D
G
I
A
G
N
L
D
L
L
G
E
F
I
----
D
S
P
A
K
C
T
E
F
A
D
--
D
V
I
-----------
K
L
----
I
E
A
A
H
A
A
-
G
I
K
P
-
Y
-
V
S
I
K
L
S
S
V
---
G
---
Q
G
K
D
E
N
----
G
E
D
L
G
-
L
-
T
N
----
A
R
-
R
I
I
A
K
A
K
E
Y
G
G
F
I
C
L
D
M
E
D
H
T
R
V
D
V
T
L
E
Q
F
R
T
L
V
G
---
E
-----
F
GA
E
---
H
--
V
G
T
V
L
Q
S
Y
L
Y
R
S
------
L
G
D
R
--------
A
S
L
D
------
D
------
L
R
P
N
---
I
R
M
V
-------
K
G
A
Y
-
L
E
P
A
T
-----------
V
A
Y
P
-
D
----------
K
----------
A
D
---------
V
D
Q
---
N
Y
R
R
L
V
F
Q
H
L
K
A
G
---
N
--
Y
---
T
N
V
A
T
H
D
E
R
I
I
D
D
V
K
R
F
V
L
A
H
G
I
G
K
D
A
F
E
F
Q
M
L
---
Y
G
I
R
R
D
L
Q
K
Q
L
A
A
------
E
------
G
--
Y
R
V
--
R
V
Y
L
P
Y
G
--
R
--
D
--
W
Y
A
Y
F
S
R
R
I
A
E
T
-
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.66
39%
-94
- C6 -
4H6R
1
?
A:
[31-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
A
--------
E
R
--------
F
V
A
G
E
S
I
E
S
A
I
Q
A
V
Q
A
L
E
R
D
G
I
A
G
N
L
D
L
L
G
E
F
I
----
D
S
P
A
K
C
T
E
F
A
D
--
D
V
I
-----------
K
L
----
I
E
A
A
H
A
A
-
G
I
K
P
-
Y
-
V
S
I
K
L
S
S
V
---
G
---
Q
G
K
D
E
N
----
G
E
D
L
G
-
L
-
T
N
----
A
R
-
R
I
I
A
K
A
K
E
Y
G
G
F
I
C
L
D
M
E
D
H
T
R
V
D
V
T
L
E
Q
F
R
T
L
V
G
---
E
-----
F
GA
E
---
H
--
V
G
T
V
L
Q
S
Y
L
Y
R
S
------
L
G
D
R
--------
A
S
L
D
------
D
------
L
R
P
N
---
I
R
M
V
-------
K
G
A
Y
-
L
E
P
A
T
-----------
V
A
Y
P
-
D
----------
K
----------
A
D
---------
V
D
Q
---
N
Y
R
R
L
V
F
Q
H
L
K
A
G
---
N
--
Y
---
T
N
V
A
T
H
D
E
R
I
I
D
D
V
K
R
F
V
L
A
H
G
I
G
K
D
A
F
E
F
Q
M
L
---
Y
G
I
R
R
D
L
Q
K
Q
L
A
A
------
E
------
G
--
Y
R
V
--
R
V
Y
L
P
Y
G
--
R
--
D
--
W
Y
A
Y
F
S
R
R
I
A
E
T
-
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
89.18
36%
-98
- C6 -
4H6Q
3
?
A:
[19-299]
-------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
E
Q
L
A
R
-
Q
-----
K
M
W
N
L
A
--------
E
R
--------
F
V
A
G
E
S
I
E
S
A
I
Q
A
V
Q
A
L
E
R
D
G
I
A
G
N
L
D
L
L
G
E
F
I
D
S
P
A
K
C
T
E
F
A
D
D
V
I
K
L
I
E
A
A
-----------
H
A
----
A
G
-------
I
-
K
-
P
Y
V
S
I
K
L
S
S
V
---
G
---
Q
G
K
D
E
N
----
G
E
D
L
G
-
L
-
T
N
----
A
R
-
R
I
I
A
K
A
K
E
Y
G
G
F
I
C
L
D
M
E
D
H
T
R
V
D
V
T
L
E
Q
F
R
T
L
V
G
---
E
-----
F
GA
E
---
H
--
V
G
T
V
L
Q
S
Y
L
Y
R
S
------
L
G
D
R
--------
A
S
L
D
------
D
------
L
R
P
N
---
I
R
M
V
-------
K
G
A
Y
-
L
E
P
A
T
-----------
V
A
Y
P
-
D
----------
K
----------
A
D
---------
V
D
Q
---
N
Y
R
R
-
L
V
F
Q
H
L
K
A
--
G
N
--
Y
---
T
N
V
A
T
H
D
E
R
I
I
D
D
V
K
R
F
V
L
A
H
G
I
G
K
D
A
F
E
F
Q
M
L
---
Y
G
I
R
R
D
L
Q
K
Q
L
A
A
------
E
------
G
--
Y
R
V
--
R
V
Y
L
P
Y
G
--
R
--
D
--
W
Y
A
Y
F
S
R
R
I
A
E
T
-
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
89.06
27%
-89
- C6 -
4NMA
7
?
A:
[116-448]
--------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
--------
R
Q
--------
F
I
V
G
E
T
T
K
E
A
V
K
N
L
E
K
L
R
K
D
G
F
A
A
V
V
D
V
L
G
E
A
T
L
S
E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
QGSWKGLP
G
K
----
G
G
D
P
G
L
D
W
G
H
A
P
K
V
N
I
A
V
K
P
T
A
L
F
CL
A
---
N
P
Q
D
F
E
----
G
S
V
V
A
I
L
-
D
R
----
M
R
-
R
I
F
K
K
V
M
E
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
R
R
L
K
L
E
Y
R
D
-----
Y
--
P
---
H
--
L
G
I
V
L
Q
A
Y
L
K
D
N
------
D
K
D
L
--------
D
D
L
L
------
A
W
A
K
E
H
K
V
Q
I
S
---
V
R
L
V
-------
K
G
A
Y
-
W
D
Y
E
T
-----------
V
K
A
K
-
Q
N
DWEVPVWTI
K
----------
A
E
---------
S
D
A
---
A
Y
E
R
-
Q
A
R
K
I
L
E
N
--
H
Q
I
C
H
---
F
A
C
A
S
H
N
I
R
T
I
S
A
V
M
E
M
A
R
E
L
N
V
P
E
D
R
Y
E
F
Q
V
L
---
Y
G
M
A
E
P
V
R
K
G
I
L
K
------
V
------
A
--
G
R
I
--
R
L
Y
A
P
Y
G
--
N
--
M
VP
G
M
G
Y
L
V
R
R
L
L
E
N
-
T
A
N
E
S
F
L
R
Q
S
F
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.94
27%
-90
- C6 -
4NM9
5
?
A:
[116-446]
--------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
--------
R
Q
--------
F
I
V
G
E
T
T
K
E
A
V
K
N
L
E
K
L
R
K
D
G
F
A
A
V
V
D
V
L
G
E
A
T
L
S
E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
QGSWKGLP
G
K
----
G
G
D
P
G
L
D
W
G
H
A
P
K
V
N
I
A
V
K
P
T
A
L
F
CL
A
---
N
P
Q
D
F
E
----
G
S
V
V
A
I
L
-
D
R
----
M
R
-
R
I
F
K
K
V
M
E
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
R
R
L
K
L
E
Y
R
D
-----
Y
--
P
---
H
--
L
G
I
V
L
Q
A
Y
L
K
D
N
------
D
K
D
L
--------
D
D
L
L
------
A
W
A
K
E
H
K
V
Q
I
S
---
V
R
L
V
-------
K
G
A
Y
-
W
D
Y
E
T
-----------
V
K
A
K
-
Q
N
DWEVPVWTI
K
----------
A
E
---------
S
D
A
---
A
Y
E
R
-
Q
A
R
K
I
L
E
N
--
H
Q
I
C
H
---
F
A
C
A
S
H
N
I
R
T
I
S
A
V
M
E
M
A
R
E
L
N
V
P
E
D
R
Y
E
F
Q
V
L
---
Y
G
M
A
E
P
V
R
K
G
I
L
K
------
V
------
A
--
G
R
I
--
R
L
Y
A
P
Y
G
--
N
--
M
V
P
G
M
G
Y
L
V
R
R
L
L
E
N
-
T
A
N
E
S
F
L
R
Q
S
F
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.85
27%
-100
- C6 -
4NME
4
?
A:
[116-448]
--------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
--------
R
Q
--------
F
I
V
G
E
T
T
K
E
A
V
K
N
L
E
K
L
R
K
D
G
F
A
A
V
V
D
V
L
G
E
A
T
L
S
E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
QGSWKGLP
G
K
----
G
G
D
P
G
L
D
W
G
H
A
P
K
V
N
I
A
V
K
P
T
A
L
F
CL
A
---
N
P
Q
D
F
E
----
G
S
V
V
A
I
L
-
D
R
----
M
R
-
R
I
F
K
K
V
M
E
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
R
R
L
K
L
E
Y
R
D
-----
Y
--
P
---
H
--
L
G
I
V
L
Q
A
Y
L
K
D
N
------
D
K
D
L
--------
D
D
L
L
------
A
W
A
K
E
H
K
V
Q
I
S
---
V
R
L
V
-------
K
G
A
Y
-
W
D
Y
E
T
-----------
V
K
A
K
-
Q
N
DWEVPVWTI
K
----------
A
E
---------
S
D
A
---
A
Y
E
R
-
Q
A
R
K
I
L
E
N
--
H
Q
I
C
H
---
F
A
C
A
S
H
N
I
R
T
I
S
A
V
M
E
M
A
R
E
L
N
V
P
E
D
R
Y
E
F
Q
V
L
---
Y
G
M
---
V
R
K
G
I
L
K
------
V
------
A
--
G
R
I
--
R
L
Y
A
P
Y
G
--
N
--
M
V
P
G
M
G
Y
L
V
R
R
L
L
E
N
-
T
A
N
E
S
F
L
R
Q
S
F
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.80
39%
-94
- C6 -
4H6R
2
?
C:
[31-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
A
--------
E
R
--------
F
V
A
G
E
S
I
E
S
A
I
Q
A
V
Q
A
L
E
R
D
G
I
A
G
N
L
D
L
L
G
E
F
I
----
D
S
P
A
K
C
T
E
F
A
D
--
D
V
I
-----------
K
L
----
I
E
A
A
H
A
A
-
G
I
K
P
-
Y
-
V
S
I
K
L
S
S
V
---
G
---
Q
G
K
D
E
N
----
G
E
D
L
G
-
L
-
T
N
----
A
R
-
R
I
I
A
K
A
K
E
Y
G
G
F
I
C
L
D
M
E
D
H
T
R
V
D
V
T
L
E
Q
F
R
T
L
V
G
---
E
-----
F
GA
E
---
H
--
V
G
T
V
L
Q
S
Y
L
Y
R
S
------
L
G
D
R
--------
A
S
L
D
------
D
------
L
R
P
N
---
I
R
M
V
-------
K
G
A
Y
-
L
E
P
A
T
-----------
V
A
Y
P
-
D
----------
K
----------
A
D
---------
V
D
Q
---
N
Y
R
R
L
V
F
Q
H
L
K
A
G
---
N
--
Y
---
T
N
V
A
T
H
D
E
R
I
I
D
D
V
K
R
F
V
L
A
H
G
I
G
K
D
A
F
E
F
Q
M
L
---
Y
G
I
R
R
D
L
Q
K
Q
L
A
A
------
E
------
G
--
Y
R
V
--
R
V
Y
L
P
Y
G
--
R
--
D
--
W
Y
A
Y
F
S
R
R
I
A
E
T
-
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
86.81
27%
-95
- C6 -
4JNY
4
PUTA_ECOLI
A:
[141-484]
---------------------------------------------------------------------------------------------------------------------------------
A
S
L
S
R
S
L
N
R
I
I
------E
P
L
I
R
K
G
V
D
M
A
M
R
L
M
G
E
Q
--------
F
V
T
G
E
T
I
A
E
A
L
A
N
A
R
K
L
E
E
K
G
F
R
Y
S
Y
D
M
L
G
E
A
A
L
T
A
A
D
A
Q
A
Y
M
V
S
Y
Q
Q
A
I
H
A
I
-----------
G
K
A
S
NG
R
G
I
Y
E
G
P
-
G
------
I
S
I
K
L
S
A
L
---
H
---
P
R
Y
S
R
A
----
Q
Y
D
R
V
-
M
-
E
E
L
Y
P
R
L
K
-
S
L
T
L
L
A
R
Q
Y
D
I
G
I
N
I
A
A
E
E
S
D
R
L
E
I
S
L
D
L
L
E
K
L
C
F
---
E
PELAG
W
--
N
---
G
--
I
G
F
V
I
Q
A
Y
Q
K
R
C
P
L
V
I
D
Y
L
I
D
L
--------
A
T
R
S
------
R
------
R
R
L
M
---
I
R
L
V
-------
K
G
A
Y
W
D
S
E
I
K
-----------
R
A
Q
M
-
D
----------
G
----------
L
E
GYPVYTR
K
V
Y
T
D
V
--
S
Y
L
A
-
C
A
K
K
L
L
A
V
--
P
N
LI
Y
---
P
Q
F
A
T
H
N
A
H
T
L
A
A
I
Y
Q
L
A
G
Q
N
-
Y
Y
P
G
Q
Y
E
F
Q
C
L
---
H
G
M
G
E
P
L
Y
E
Q
V
T
G
------
K
VADGKL
N
--
R
P
C
--
R
I
Y
A
P
V
G
--
T
--
H
ET
L
L
A
Y
L
V
R
R
L
L
E
N
-
G
A
N
T
S
F
V
N
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
85.77
27%
-94
- C6 -
4JNZ
4
PUTA_ECOLI
A:
[141-484]
---------------------------------------------------------------------------------------------------------------------------------
A
S
L
S
R
S
L
N
R
I
I
-------
P
L
I
R
K
G
V
D
M
A
M
R
L
M
G
E
Q
--------
F
V
T
G
E
T
I
A
E
A
L
A
N
A
R
K
L
E
E
K
G
F
R
Y
S
Y
D
M
L
G
E
A
A
L
T
A
A
D
A
Q
A
Y
M
V
S
Y
Q
Q
A
I
H
A
I
-----------
G
K
A
S
NG
R
G
I
Y
E
G
P
-
G
------
I
S
I
K
L
S
A
L
---
H
---
P
R
Y
S
R
A
----
Q
Y
D
R
V
-
M
-
E
E
L
Y
P
R
L
K
-
S
L
T
L
L
A
R
Q
Y
D
I
G
I
N
I
N
A
E
E
S
D
R
L
E
I
S
L
D
L
L
E
K
L
C
F
---
E
PELAG
W
--
N
---
G
--
I
G
F
V
I
Q
A
Y
Q
K
R
C
P
L
V
I
D
Y
L
I
D
L
--------
A
T
R
S
------
R
------
R
R
L
M
---
I
R
L
V
-------
K
G
A
Y
W
D
S
E
I
K
-----------
R
A
Q
M
-
D
----------
G
----------
L
E
GYPVYTR
K
V
Y
T
D
V
--
S
Y
L
A
-
C
A
K
K
L
L
A
V
--
P
N
LI
Y
---
P
Q
F
A
T
H
N
A
H
T
L
A
A
I
Y
Q
L
A
G
Q
N
-
Y
Y
P
G
Q
Y
E
F
Q
C
L
---
H
G
M
G
E
P
L
Y
E
Q
V
T
G
------
K
VADGKL
N
--
R
P
C
--
R
I
Y
A
P
V
G
--
T
--
H
ET
L
L
A
Y
L
V
R
R
L
L
E
N
-
G
A
N
T
S
F
V
N
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
82.16
26%
-81
- C6 -
3HAZ
7
?
A:
[151-472]
------------------------------------------------------------------------------------------------------------------------------------
A
P
A
V
R
T
A
T
R
------
Q
A
M
R
L
M
G
--------
N
H
--------
F
V
L
G
E
T
I
E
Q
A
L
E
R
G
K
P
R
S
G
Q
K
T
R
Y
S
F
D
M
L
G
E
G
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
A
I
E
T
I
-----------
G
K
----
A
A
-
G
N
H
A
-
L
P
D
R
-
P
G
I
S
V
K
L
S
A
L
---
H
---
P
R
F
E
A
I
S
R
A
R
V
M
V
E
L
-
V
-
P
Q
----
L
L
-
D
L
A
Q
R
A
K
A
H
D
L
N
F
T
V
D
A
E
E
A
D
R
L
E
L
S
L
D
V
I
A
A
T
L
A
---
D
PSLKG
W
--
D
---
G
--
F
G
L
A
I
Q
A
Y
Q
K
R
A
------
S
A
V
I
--------
D
Y
V
D
A
L
A
R
A
H
D
------
R
K
L
M
---
V
R
L
V
-------
K
G
A
Y
-
W
D
T
E
I
K
R
A
Q
E
R
GLDGY
P
V
F
T
-
R
----------
K
----------
A
M
---------
T
D
L
---
N
Y
V
A
-
C
A
S
K
L
L
A
L
RP
R
I
--
F
---
P
Q
F
A
T
H
N
A
L
T
V
A
T
V
L
E
M
A
E
G
----
S
S
G
F
E
F
Q
R
L
---
H
G
M
G
E
A
L
Y
E
Q
L
A
K
------
D
------
H
AD
I
A
Y
--
R
T
Y
A
P
V
G
--
S
HR
D
--
L
L
A
Y
L
V
R
R
L
L
E
N
-
G
A
N
S
S
F
V
A
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
80.69
30%
-73
- C6 -
4Q71
7
?
A:
[3-990]
MPNIPPPFTAPYAPD
D
A
E
I
A
A
R
L
L
P
A
S
HLS
P
P
Q
E
A
R
I
H
R
T
A
T
R
L
I
E
A
I
R
KRLGG
V
E
D
M
L
R
E
F
ALS
T
K
E
G
L
A
L
M
V
L
A
E
A
L
L
R
VPD
A
R
T
A
D
Q
F
I
E
DKLGEGD
F
I
H
H
E
T
K
S
T
A
F
L
V
N
A
S
A
W
A
R
V
I
Q
-
P
G
E
T
P
D
G
---
T
I
G
R
L
V
K
-
R
LG
A
-
P
A
V
R
T
A
T
--------
R
Q
A
M
R
L
M
G
N
H
F
V
L
G
E
T
I
E
Q
A
L
E
R
G
K
P
G
Q
K
T
R
Y
--
S
F
D
M
L
G
E
G
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
A
I
E
T
I
-----------
G
K
----
A
A
G
N
H
A
L
-
P
D
R
P
--
G
I
S
V
K
L
S
A
L
---
H
PRF
E
A
I
S
R
A
----
R
V
M
V
E
-
L
V
P
Q
----
L
L
-
D
L
A
Q
R
A
K
A
H
D
L
N
F
T
V
D
A
E
E
A
D
R
L
E
L
S
L
D
V
I
A
A
T
L
A
---
D
-----
P
--
S
LKG
W
DG
F
G
L
A
I
Q
A
Y
Q
K
R
A
S
A
V
---
I
D
Y
V
--------
D
A
L
A
------
R
------
A
H
D
R
K
L
M
V
R
L
V
-------
K
G
A
Y
-
W
D
T
E
I
-----------
K
R
A
Q
-
E
----------
R
GLDGYPVFTR
K
A
---------
M
T
D
L
--
N
Y
V
A
-
C
A
S
K
L
L
A
L
--
R
P
R
I
F
---
P
Q
F
A
T
H
N
A
L
T
V
A
T
V
L
E
M
A
E
G
S
S
----
G
F
E
F
Q
R
L
---
H
G
M
G
E
A
L
Y
E
Q
L
A
K
------
D
------
H
--
A
D
I
A
Y
R
T
Y
A
P
V
G
S
H
R
--
D
--
L
L
A
Y
L
V
R
R
L
L
E
N
-
G
A
N
S
S
F
V
A
Q
A
A
D
Y
R
V
P
V
P
A
L
L
Q
R
P
A
D
A
I
VRPQAAAHPRIPLPCDLFAPE
R
R
N
S
R
G
V
E
FGA
R
T
A
L
D
Q
L
L
T
D
V
K
A
EI
A
D
A
T
P
D
Q
A
H
A
A
V
A
A
A
R
A
G
F
A
G
W
S
R
TP
A
G
I
R
A
A
A
L
E
Q
A
A
H
L
L
E
S
R
S
A
H
F
I
A
L
L
Q
R
EGGKT
L
D
D
A
L
S
E
L
R
E
A
A
D
F
C
R
Y
Y
A
A
Q
G
R
K
L
FG
S
E
T
A
M
P
G
P
T
G
E
S
N
A
L
T
M
R
G
R
G
V
F
V
A
I
S
P
WNFPL
A
I
F
L
G
Q
V
T
A
A
L
M
A
G
N
S
V
V
A
K
P
A
EQT
P
R
I
A
R
E
A
V
A
L
L
H
E
A
GIPKSA
L
Y
L
V
T
G
D
G
R
I
G
A
A
L
T
A
HPDIA
G
V
V
F
T
G
S
T
E
V
A
R
S
I
N
R
A
L
A
A
KDGPI
V
P
L
I
A
E
T
G
G
I
N
A
M
I
A
D
ATAL
P
E
Q
V
A
D
W
V
V
T
S
A
FRSAGQRCSALR
L
L
F
V
Q
EDV
A
D
R
M
I
E
M
V
A
G
A
A
R
E
LKIGDPSDVATHVGPVID
V
E
A
K
Q
R
L
D
A
H
I
A
R
M
K
T
E
ARLH
F
A
G
P
A
P
EGCFV
A
P
H
I
F
E
L
TEAGQLTEEVFGP
I
L
H
V
V
R
Y
R
PEN
L
E
R
V
L
R
A
I
E
R
T
GYGL
T
L
G
V
H
S
RI
D
D
S
I
E
A
I
I
D
R
VQVG
N
I
Y
V
NRNMIGAVVGVQP
F
G
G
N
GLSGTGPKAGGPH
Y
L
A
R
F
A
T
E
Q
T
V
T
I
NTAAA
50
Fugue
58.28
20%
-55
- C3 -
4M59
3
?
A:
[6-714]
---------------------------------------------------PD
A
Q
V
L
V
L
A
I
S
S
HPLPT
L
A
A
F
L
A
S
R
R
D
E
L
L
R
AD
I
T
S
L
L
K
A
L
E
L
S
GH
W
E
W
A
L
A
L
L
R
W
A
G
K
E
GA
A
D
A
S
A
L
E
M
V
V
-
R
A
L
G
R
E
G
Q
H
D
A
V
C
A
L
L
D
-
E
--
T
-
P
L
P
P
G
----------------------
S
R
L
D
V
R
A
Y
T
T
V
L
H
A
L
S
R
A
G
R
Y
E
R
A
L
E
L
F
A
E
L
R
R
-
Q
G
V
A
P
T
L
V
T
Y
N
V
V
L
D
V
Y
-----------
G
R
----
M
G
R
------------
S
W
P
R
I
V
A
L
---
L
---
D
E
M
R
A
A
----
G
V
E
P
D
-
G
-
F
T
----
A
S
-
T
V
I
A
A
C
S
R
D
G
---------------------------------------------------
L
V
D
E
A
------
V
A
F
F
--------
E
D
L
K
------
A
------
R
G
---------------------
H
A
P
S
V
-----------
V
T
Y
N
-
A
----------
L
----------
L
Q
---------
V
F
G
KAG
N
Y
T
E
-
A
L
R
V
L
G
E
M
--
E
Q
--
N
G
C
Q
P
D
A
V
T
Y
N
E
L
A
G
T
E
E
A
A
R
C
L
D
T
M
A
S
P
N
A
F
T
Y
N
T
V
M
T
A
Y
G
N
V
G
K
V
D
E
A
L
A
L
------
F
------
D
--
Q
M
K
--
K
T
G
F
V
P
N
--
V
--
N
--
T
Y
N
L
V
L
G
M
L
G
K
K
--
S
R
F
T
V
M
L
E
M
L
G
E
M
S
R
S
G
C
T
P
N
R
V
T
W
N
T
M
L
AVSGKRG
M
E
D
Y
V
T
R
V
L
E
G
M
R
S
S
G
V
E
L
S
R
D
T
Y
N
T
L
I
A
A
Y
G
R
C
GS
R
T
N
A
F
K
M
Y
N
E
M
T
S
A
G
F
T
P
C
I
T
T
Y
N
A
L
L
N
V
L
S
R
Q
GD
W
S
T
A
Q
S
I
V
S
K
M
R
T
K
G
F
K
P
N
E
Q
S
Y
S
L
L
L
Q
C
Y
A
K
G
GN
V
A
G
I
A
A
I
E
N
E
V
Y
GSGAVFPS
W
V
I
L
R
T
L
V
I
A
N
F
K
C
RR
L
D
G
M
E
T
A
F
Q
E
V
K
A
RG
Y
N
P
D
L
V
I
F
N
S
M
L
S
I
Y
A
K
N
GM
Y
S
K
A
T
E
V
F
D
S
I
K
R
S
G
L
S
P
D
L
I
T
Y
N
S
L
M
D
M
Y
A
K
C
SE
S
W
E
A
E
K
I
L
N
Q
L
K
C
SQTMKPD
V
V
S
Y
N
T
V
I
N
G
F
C
K
QGL
V
K
E
A
Q
R
V
L
S
E
M
V
A
D
G
M
A
P
C
A
V
T
Y
H
T
L
V
G
G
Y
S
S
LEMF
S
E
A
R
E
V
I
G
Y
M
V
QHGLKPMEL
T
Y
R
R
V
V
E
S
Y
C
R
AF
E
E
A
R
G
F
L
S
EVKAL
E
A
Y
I
E
D
A---------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
51.25
18%
-37
- C4 -
4TXA
2
RC3H1_MOUSE
A:
[6-399]
------------------------------------------------------------------------------------------------------PQWTDFLSCPI
C
T
Q
T
F
D
E
T
I
R
K
P
I
S
L
G
C
G
H
-----
T
V
C
K
-
M
--
C
-
L
N
K
L
H
----------
R
K
--------
A
C
P
F
D
Q
T
T
I
N
T
D
I
-
E
L
L
P
V
N
S
A
L
L
Q
L
V
G
L
C
S
G
V
E
D
T
K
H
Y
E
E
A
K
K
C
V
E
E
L
A
L
Y
L
-----------
K
P
----
V
L
S
-------
R
P
-
M
Q
R
K
L
V
T
L
V
H
---
C
---
Q
L
V
E
E
E
----
G
R
I
R
A
-
M
-
R
A
----
A
R
-
S
L
G
E
R
T
V
T
E
L
I
---
L
Q
H
Q
N
P
Q
Q
L
S
S
N
L
W
A
A
V
R
A
R
----
G
-----
C
--
Q
---
F
--
L
G
P
A
R
Q
E
E
A
L
K
L
------
V
L
L
A
L
EDG
S
A
L
S
R
K
V
L
------
V
------
L
F
V
V
---
Q
R
L
E
PRFPQAS
K
T
S
I
-
G
H
V
V
Q
-----------
L
L
Y
R
A
S
----------
C
----------
F
K
---------
V
T
K
---
R
D
S
S
-
L
M
Q
L
K
E
E
F
--
R
T
--
Y
E
--
A
L
R
R
E
H
D
S
Q
I
V
Q
I
A
M
E
---
A
G
L
R
I
A
P
D
Q
W
S
S
L
L
---
Y
G
D
Q
S
H
-
K
S
H
M
Q
S
------
I
------
I
--
D
K
L
--
Q
T
P
A
S
F
A
--
Q
--
S
--
V
Q
E
L
T
I
A
L
Q
R
T
G
D
P
A
N
L
N
R
L
R
P
H
L
E
L
L
A
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I
D
P
S
P
D
A
PPPT
W
E
Q
L
E
N
G
L
V
A
V
R
T
V
V
H
G
L
V
D
Y
I
Q
NHS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
47.55
11%
-50
- C6 -
1YX1
2
?
A:
[5-254]
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H
P
V
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Q
------------------------------------------
L
D
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A
M-----
T
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G
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------
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------
Q
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---------------------
Q
A
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-----------
A
A
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-
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----------
G
----------
R
Y
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V
G
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---
V
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K
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D
D
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-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------