@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1207: (2016-04-29 )
MRSTPPASAGRSTPPALAGHSTPPALAGHSTLCGRPVAGDRALIMAIVNRTPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPGERVDVDTEITRLVPFIEWLRGAYPDQLISVDTWRAQVAKAACAAGADLINDTWGGVDPAMPEVAAEFGAGLVCAHTGGALPRTRPFRVSYGTTTRGVVDAVISQVTAAAERAVAAGVAREKVLIDPAHDFGKNTFHGLLLLRHVADLVMTGWPVLMALSNKDVVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEVAATRRVLEMVASIQGVRPPTRTVRGLA
Atome Classification :
(70 SA)
.........10........20........30....-....-40-.........50........60..-......70.....-----...80........90.-.-.-.....100.......110...----....120.......130.......140.....-.-.-150......--------.-160-------.........170...-...-.180...------------------------....190.......200.......210.......220..----..-...230.......240---.----------------..--......250.......260-..------.-----..--....--------270.......280.......290.......300.......310......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRSTPPASAGRSTPPALAGHSTPPALAGHSTLCGR-PVAG-
D
--
R
A
L
I
M
A
I
V
NRTP
D
S
FYDKGATF
S
-
D
A
A
A
R
D
A
V
H
R
A
VA-----DGA
D
V
I
D
VGGVKAGPG-E-R-VDV
D
T
E
I
T
R
L
V
P
F
I
E
W
L
RGAY----PD
Q
L
I
S
V
D
T
W
R
A
Q
V
A
K
A
A
C
AA
G
A
D
L
I
NDTWGG-V-D-P
A
M
P
E
V
A
A
E
--------F-G---------A
G
L
V
C
AHTGGALPRT-R
P
F
-
R
V
SYGTT------------------------T
R
G
V
V
D
A
V
I
S
Q
V
T
A
A
A
E
R
A
V
A
AGVAR
E
K
V
L
IDP
A
H
DFG
K
----
N
T
-
F
H
G
L
L
L
L
R
H
V
A
D
L
V
-----M----------------TG--W
P
V
L
M
A
LSNKDVVGETL---G
V
------
D
-----
L
T
--
E
R
L
E
--------
G
T
L
A
A
T
A
L
A
A
AAG
A
R
M
F
R
V
H
E
V
A
A
T
R
R
V
L
E
M
V
A
S
IQGVRPP
T
R
T
VRGLA
95
HHSearch
95.42
100%
-143
- C6 -
2VP8
2
DHPS2_MYCTU
A:
[27-311]
--------------------------
A
G
H
S
T
L
C
G
R
-
P
V
A
G
-
D
--
R
A
L
I
M
A
I
V
N
---------------
D
A
A
A
R
D
A
V
H
R
A
V
A
-----
D
G
A
D
V
I
D
V
G
-------------
D
V
D
T
E
I
T
R
L
V
P
F
I
E
W
L
R
G
A
Y
----
P
D
Q
L
I
S
V
D
T
W
R
A
Q
V
A
K
A
A
C
A
A
G
A
D
L
I
N
D
T
W
G
G
-
V
-
D
-
P
A
M
P
E
V
A
A
E
--------
F
-
G
---------
A
G
L
V
C
A
H
T
---------------
Y
G
T
T
------------------------
T
R
G
V
V
D
A
V
I
S
Q
V
T
A
A
A
E
R
A
V
A
A
G
V
A
R
E
K
V
L
I
D
P
A
H
D
F
G
K
----
N
T
-
F
H
G
L
L
L
L
R
H
V
A
D
L
V
-----
M
----------------
T
G
--
W
P
V
L
M
A
L
S
-------------------------------
R
L
E
--------
G
T
L
A
A
T
A
L
A
A
A
A
G
A
R
M
F
R
V
H
E
V
A
A
T
R
R
V
L
E
M
V
A
S
I
Q
G
V
R
P
P
T
-------
1
PsiBlast_PDB
95.21
99%
-143
- C6 -
2VP8
2
DHPS2_MYCTU
A:
[27-311]
--------------------------
A
G
H
S
T
L
C
G
R
-
P
V
A
G
-
D
--
R
A
L
I
M
A
I
V
N
---------------
D
A
A
A
R
D
A
V
H
R
A
V
A
-----
D
G
A
D
V
I
D
V
G
-------------
D
V
D
T
E
I
T
R
L
V
P
F
I
E
W
L
R
G
A
Y
----
P
D
Q
L
I
S
V
D
T
W
R
A
Q
V
A
K
A
A
C
A
A
G
A
D
L
I
N
D
T
W
G
G
-
V
-
D
-
P
A
M
P
E
V
A
A
E
--------
F
-
G
---------
A
G
L
V
C
A
H
T
---------------
Y
G
T
T
------------------------
T
R
G
V
V
D
A
V
I
S
Q
V
T
A
A
A
E
R
A
V
A
A
G
V
A
R
E
K
V
L
I
D
P
A
H
D
F
G
K
----
N
T
-
F
H
G
L
L
L
L
R
H
V
A
D
L
V
-----
M
----------------
T
G
--
W
P
V
L
M
A
L
S
-------------------------------
R
L
E
--------
G
T
L
A
A
T
A
L
A
A
A
A
G
A
R
M
F
R
V
H
E
V
A
A
T
R
R
V
L
E
M
V
A
S
I
Q
G
V
R
P
P
T
-------
21
PsiBlast_CBE
91.36
99%
-136
- C6 -
2VP8
1
DHPS2_MYCTU
B:
[29-310]
----------------------------
H
S
T
L
C
G
R
-
P
V
A
G
-
D
--
R
A
L
I
M
A
I
V
N
R
T
-------------
D
A
A
A
R
D
A
V
H
R
A
V
A
-----
D
G
A
D
V
I
D
V
G
G
-----------
V
D
V
D
T
E
I
T
R
L
V
P
F
I
E
W
L
R
G
A
Y
----
P
D
Q
L
I
S
V
D
T
W
R
A
Q
V
A
K
A
A
C
A
A
G
A
D
L
I
N
D
T
W
G
G
-
V
-
D
-
P
A
M
P
E
V
A
A
E
--------
F
-
G
---------
A
G
L
V
C
A
H
T
---------------
Y
G
T
T
------------------------
T
R
G
V
V
D
A
V
I
S
Q
V
T
A
A
A
E
R
A
V
A
A
G
V
A
R
E
K
V
L
I
D
P
A
H
D
F
G
K
----
N
T
-
F
H
G
L
L
L
L
R
H
V
A
D
L
V
-----
M
----------------
T
G
--
W
P
V
L
M
A
L
S
N
-----------------------------
E
R
L
E
--------
G
T
L
A
A
T
A
L
A
A
A
A
G
A
R
M
F
R
V
H
E
V
A
A
T
R
R
V
L
E
M
V
A
S
I
Q
G
V
R
P
P
--------
85
Fugue
73.28
36%
-102
- C6 -
1AD1
2
DHPS_STAAU
A:
[1-264]
-----------------------------------------
T
--
K
T
K
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
K
F
N
N
-
V
E
S
A
V
T
R
V
K
A
M
M
D
-----
E
G
A
D
I
I
D
V
G
G
V
S
T
R
P
G
H
E
-
M
-
I
T
V
E
E
E
L
N
R
V
L
P
V
V
E
A
I
V
G
------
F
D
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
I
I
N
D
Q
W
A
G
-
L
Y
D
-
H
R
M
F
Q
V
V
A
K
--------
Y
-
D
---------
A
E
I
V
L
M
H
N
-
G
N
G
N
R
D
-------------------------------------
E
P
V
V
E
E
M
L
T
S
L
L
A
Q
A
H
Q
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
A
K
----
T
R
-
N
E
E
A
E
V
M
A
R
L
D
E
L
V
-----
A
----------------
T
E
--
Y
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
---
G
Y
------
D
TT---
P
V
--
E
R
D
E
--------
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
E
L
N
A
K
L
A
K
G
I
D
F
L
K
E
N
E
N
A
-
R
H
N
----
65
PsiBlast_CBE
72.40
37%
-104
- C6 -
1AD1
2
DHPS_STAAU
A:
[2-242]
--------------------------------------------
K
T
K
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
K
F
N
N
-
V
E
S
A
V
T
R
V
K
A
M
M
D
-----
E
G
A
D
I
I
D
V
G
G
V
S
T
R
P
G
H
E
-
M
-
I
T
V
E
E
E
L
N
R
V
L
P
V
V
E
A
I
V
G
F
------
D
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
I
I
N
D
Q
W
A
G
-
L
Y
D
-
H
R
M
F
Q
V
V
A
K
--------
Y
-
D
---------
A
E
I
V
L
M
H
N
G
N
--------------
G
N
R
------------------------
D
E
P
V
V
E
E
M
L
T
S
L
L
A
Q
A
H
Q
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
A
K
----
T
R
-
N
E
E
A
E
V
M
A
R
L
D
E
L
V
-----
A
----------------
T
E
--
Y
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
---
G
Y
------
D
-----
T
T
PV
E
R
D
E
--------
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
---------------------------
97
HHSearch
71.18
30%
-90
- C6 -
2BMB
1
FOL1_YEAST
A:
[221-543]
--------------------------------------
T
V
-
S
--
P
T
Y
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
H
F
A
D
I
E
S
Q
L
N
D
I
I
K
L
C
K
D
A
L
YL
H
E
S
V
I
I
D
V
G
G
C
S
T
R
P
N
-
S
I
Q
-
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
R
E
S
T
ELPQ
D
K
V
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
I
N
D
I
S
G
G
-
L
F
D
-
S
N
M
F
A
V
I
A
E
--------
N
P
E
---------
I
C
Y
I
L
S
H
T
R
G
D
-
I
S
T
-
M
N
R
-
L
A
H
Y
E
N
F
ALGDSIQ
Q
E
F
V
HNTDIQQLDD
L
K
D
K
T
V
L
I
R
N
V
G
Q
E
I
G
E
R
Y
I
K
A
I
D
N
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
F
A
K
----
T
W
-
K
Q
N
L
Q
I
I
R
H
I
P
I
L
K
-----
N
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
L
R
N
--
M
P
V
L
L
G
P
S
R
K
K
F
I
G
H
I
T
---
K
D
------
V
D----
A
K
--
Q
R
D
F
--------
A
T
G
A
V
V
A
S
C
I
G
F
G
S
D
M
V
R
V
H
D
V
K
N
C
S
K
S
I
K
L
A
D
A
I
Y
K
G
-----------
14
PsiBlast_PDB
70.98
34%
-96
- C6 -
3H2E
4
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
-
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
103
HHSearch
70.48
35%
-104
* C6 *
4HB7
6
DHPS_STAAM
A:
[5-264]
-----------------------------------------
T
--
K
T
K
I
M
G
I
L
N
V
T
----------
N
N
-
V
E
T
A
I
N
R
V
K
A
M
I
D
-----
E
G
A
D
I
I
D
V
G
G
V
S
T
R
P
G
-
H
E
M
-
V
T
L
E
E
E
L
N
R
V
L
P
V
V
E
A
I
V
G
------
F
D
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
M
I
N
D
Q
W
A
G
-
L
Y
D
-
H
R
M
F
Q
I
V
A
K
--------
Y
-
D
---------
A
E
I
I
L
M
H
N
G
N
G
N
R
D
E
--------------------------------------
P
V
V
E
E
M
L
T
S
L
L
A
Q
A
H
Q
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
A
K
----
T
R
-
N
E
E
A
E
V
M
A
R
L
D
E
L
V
-----
A
----------------
T
E
--
Y
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
---
G
Y
DT----
T
-----
P
V
--
E
R
D
E
--------
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
E
L
N
A
K
L
A
K
G
I
D
F
L
K
E
N
E
N
---------
2
PsiBlast_PDB
70.45
34%
-95
- C6 -
1TWS
6
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
-
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
98
HHSearch
70.23
34%
-97
- C6 -
4NIR
8
?
A:
[27-294]
-----------------------------
L
R
C
G
E
Y
-
T
L
N
L
N
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
-
F
A
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
-
K
-
A
E
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
-
M
---------
N
Y
R
----------------------------
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-----------
27
PsiBlast_CBE
70.23
34%
-107
- C6 -
4NHV
9
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
6
PsiBlast_PDB
70.10
34%
-102
- C6 -
1TX2
6
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----F
A
-
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
52
PsiBlast_CBE
69.96
34%
-106
- C6 -
3H2A
5
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
--------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
26
PsiBlast_CBE
69.89
34%
-94
- C6 -
4NIL
6
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
-
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
24
PsiBlast_CBE
69.87
34%
-97
- C6 -
4NIR
8
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
-
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
41
PsiBlast_CBE
69.84
34%
-105
- C6 -
3TYE
7
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
-------
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
---------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
69
PsiBlast_CBE
69.78
33%
-91
- C6 -
3TZF
3
?
B:
[4-279]
-----------------------------
M
H
L
T
A
R
-
G
L
T
L
-
D
LS
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
---
E
-
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
-
Q
-
E
-
P
G
A
L
E
A
A
A
K
--------
T
-
G
---------
L
P
V
C
L
M
H
M
Q
G
------
Q
P
K
-
N
M
Q
H
S
P
Y
------------------------
Y
D
D
L
M
T
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
G
K
----
N
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
--
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
V
------
P
-----
P
Q
--
Q
R
V
I
--------
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
-------
T
R
S
A
K
---
25
PsiBlast_CBE
69.73
34%
-108
- C6 -
4NIL
7
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
-------
A
-
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
39
PsiBlast_CBE
69.71
34%
-111
- C6 -
4D8A
6
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
----------
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-------------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
34
PsiBlast_CBE
69.61
34%
-115
- C6 -
4DAF
5
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
----------
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-------------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
13
PsiBlast_PDB
69.58
34%
-106
- C6 -
3H2C
6
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
---------
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-
E
S
T
R
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
5
PsiBlast_PDB
69.58
34%
-105
- C6 -
1TX0
6
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
70
PsiBlast_CBE
69.56
33%
-88
- C6 -
3TZF
2
?
A:
[4-278]
-----------------------------
M
H
L
T
A
R
-
G
L
T
L
-
D
LS
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
-
A
A
E
-
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
-
Q
-
E
-
P
G
A
L
E
A
A
A
K
--------
T
-
G
---------
L
P
V
C
L
M
H
M
Q
G
------
Q
P
K
-
N
M
Q
H
S
P
Y
------------------------
Y
D
D
L
M
T
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
G
K
----
N
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
--
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
V
------
P
-----
P
Q
--
Q
R
V
I
--------
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
-------
T
R
S
A
----
44
PsiBlast_CBE
69.51
34%
-102
- C6 -
3TYD
8
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
-
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
12
PsiBlast_PDB
69.51
34%
-108
- C6 -
3H2A
4
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
------------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
43
PsiBlast_CBE
69.44
34%
-106
- C6 -
3TYD
7
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
---------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
10
PsiBlast_PDB
69.40
34%
-100
- C6 -
3H24
6
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
--------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
16
PsiBlast_PDB
69.28
34%
-98
- C6 -
3H2M
5
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----F
A
-
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
40
PsiBlast_CBE
69.23
34%
-105
- C6 -
4D8A
5
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
----------
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
15
PsiBlast_PDB
69.15
34%
-102
- C6 -
3H2F
4
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
-----F
A
-
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
42
PsiBlast_CBE
69.09
34%
-103
- C6 -
3TYE
5
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
------
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
-
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
55
PsiBlast_CBE
69.05
34%
-107
- C6 -
1TX2
6
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
-----------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
7
PsiBlast_PDB
69.05
34%
-103
- C6 -
3H21
4
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
------------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
51
PsiBlast_CBE
69.04
34%
-109
- C6 -
3H2C
7
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
-------
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
35
PsiBlast_CBE
68.99
34%
-107
- C6 -
4D9P
6
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
-----
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
54
PsiBlast_CBE
68.98
34%
-107
- C6 -
3H21
4
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
-------
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
------------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
29
PsiBlast_CBE
68.82
34%
-110
- C6 -
4DB7
6
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
-------
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-------------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
37
PsiBlast_CBE
68.79
34%
-107
- C6 -
4D8Z
6
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
46
PsiBlast_CBE
68.73
34%
-102
- C6 -
3TYB
7
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
17
PsiBlast_PDB
68.70
34%
-105
- C6 -
3H2N
5
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
---
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
33
PsiBlast_CBE
68.69
34%
-112
- C6 -
4DAF
5
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
----------
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-------------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
20
PsiBlast_PDB
68.53
34%
-105
- C6 -
3TYB
5
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
--------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
48
PsiBlast_CBE
68.35
34%
-103
- C6 -
3H2N
5
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
--------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
11
PsiBlast_PDB
68.24
34%
-100
- C6 -
3H26
4
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
------------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
45
PsiBlast_CBE
68.13
34%
-106
- C6 -
3TYC
7
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
--------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
32
PsiBlast_CBE
68.12
34%
-102
- C6 -
4DAI
5
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-------------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
100
HHSearch
68.10
34%
-95
- C6 -
1AJ0
3
DHPS_ECOLI
A:
[4-280]
------------------------------
F
A
Q
G
T
-
S
L
D
L
-
S
--
H
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
-
A
A
E
-
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
-----
F
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
-
S
-
E
-
P
G
A
L
E
A
A
A
E
--------
T
-
G
---------
L
P
V
C
L
M
H
M
Q
G
N
-
P
K
T
-
M
Q
E
-
A
P
K
Y
D
----------------------------
D
V
F
A
E
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
G
K
----
N
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
--
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
---
N
V
------
G
-----
P
S
--
E
R
L
S
--------
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
N
K
R
------
8
PsiBlast_PDB
67.90
34%
-104
- C6 -
3H22
5
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
--
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
------------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
49
PsiBlast_CBE
67.79
34%
-104
- C6 -
3H2M
7
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
-----------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
38
PsiBlast_CBE
67.76
34%
-106
- C6 -
4D8Z
5
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
-
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
----------
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
72
PsiBlast_CBE
67.69
33%
-87
- C6 -
3TYZ
4
?
A:
[4-278]
-----------------------------
M
H
L
T
A
R
-
G
L
T
L
-
D
LS
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
-
A
A
E
-
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
-
Q
-
E
-
P
G
A
L
E
A
A
A
K
--------
T
-
G
---------
L
P
V
C
L
M
H
M
Q
G
------
Q
P
K
-
N
M
Q
H
S
P
Y
------------------------
Y
D
D
L
M
T
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
G
K
----
N
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
--
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
V
------
P
-----
P
Q
--
Q
R
V
I
--------
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
-------
T
R
S
A
----
31
PsiBlast_CBE
67.66
34%
-108
- C6 -
4DAI
6
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-------------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
57
PsiBlast_CBE
67.65
34%
-103
- C6 -
1TWZ
5
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
56
PsiBlast_CBE
67.60
34%
-104
- C6 -
1TX0
6
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
-----------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
47
PsiBlast_CBE
67.47
34%
-98
- C6 -
3TYA
7
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
71
PsiBlast_CBE
67.45
33%
-87
- C6 -
3TYZ
4
?
B:
[4-279]
-----------------------------
M
H
L
T
A
R
-
G
L
T
L
-
D
LS
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
-
A
A
E
-
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
-
Q
-
E
-
P
G
A
L
E
A
A
A
K
--------
T
-
G
---------
L
P
V
C
L
M
H
M
Q
G
------
Q
P
K
-
N
M
Q
H
S
P
Y
------------------------
Y
D
D
L
M
T
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
G
K
----
N
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
--
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
V
------
P
-----
P
Q
--
Q
R
V
I
--------
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
-------
T
R
S
A
K
---
30
PsiBlast_CBE
67.43
34%
-106
- C6 -
4DB7
5
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
---
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-------------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
53
PsiBlast_CBE
67.28
34%
-105
- C6 -
3H24
8
?
B:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
------
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
67
PsiBlast_CBE
67.08
34%
-95
- C6 -
1AJ2
2
DHPS_ECOLI
A:
[17-280]
-----------------------------------------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
-
A
A
E
-
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
F
-----
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
-
S
-
E
-
P
G
A
L
E
A
A
A
E
--------
T
-
G
---------
L
P
V
C
L
M
H
M
Q
G
N
-
P
K
T
-
M
Q
E
-
A
P
K
Y
D
D
V
------------------------
F
A
E
V
N
R
Y
F
I
E
Q
I
A
----
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
G
K
----
N
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
--
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
---
N
V
------
G
-----
P
S
--
E
R
L
S
--------
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
N
K
R
------
36
PsiBlast_CBE
66.94
34%
-103
- C6 -
4D9P
5
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
-----------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
68
PsiBlast_CBE
66.20
34%
-92
- C6 -
1AJ0
3
DHPS_ECOLI
A:
[17-280]
-----------------------------------------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
-
A
A
E
-
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
F
-----
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
-
S
-
E
-
P
G
A
L
E
A
A
A
E
--------
T
-
G
---------
L
P
V
C
L
M
H
M
Q
G
N
-
P
K
T
-
M
Q
E
-
A
P
K
Y
D
D
V
------------------------
F
A
E
V
N
R
Y
F
I
E
Q
I
A
----
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
G
K
----
N
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
--
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
---
N
V
------
G
-----
P
S
--
E
R
L
S
--------
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
N
K
R
------
101
HHSearch
64.71
35%
-100
- C6 -
1EYE
2
DHPS1_MYCTU
A:
[5-274]
--------------------------------------------
P
V
Q
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
G
I
V
D
V
G
G
----------------
E
T
S
R
V
I
P
V
V
K
E
L
A
A
------
Q
G
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
-
R
-
A
D
P
A
M
G
P
L
L
A
E
--------
A
-
D
---------
V
P
W
V
L
M
H
W
R
A
V
-
S
A
D
T
P
H
V
-
P
V
R
Y
G
----------------------------
N
V
V
A
E
V
R
A
D
L
L
A
S
V
A
D
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
F
A
K
----
T
A
-
Q
H
N
W
A
I
L
H
A
L
P
E
L
V
-----
A
----------------
T
G
--
I
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
---
A
G
PDGVMR
P
-----
T
D
--
G
R
D
T
--------
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
W
M
G
A
E
----------
18
PsiBlast_PDB
64.29
34%
-102
- C6 -
3H2O
3
?
A:
[37-293]
---------------------------------------
N
-
E
--
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
A
A
V
R
H
A
-
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
----------
K
-
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
-
E
-
P
K
I
A
E
V
A
A
H
--------
Y
-
D
---------
V
P
I
I
L
M
H
N
R
D
N
M
--------------
N
------------------------
Y
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
K
----
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
--
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
L
------
P
-----
V
E
--
E
R
L
E
--------
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
------------
99
HHSearch
64.03
35%
-100
- C6 -
2Y5S
13
?
A:
[6-292]
------------------------
F
L
P
A
P
L
Q
C
G
R
F
-
E
L
T
F
-
E
--
R
P
L
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
-
A
P
P
-
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
------
L
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
-
R
-
Q
-
P
G
A
I
D
A
V
R
D
--------
G
-
N
---------
S
G
L
C
A
M
H
M
L
G
E
-
P
Q
T
-
M
Q
V
G
E
P
D
Y
G
----------------------------
D
V
V
T
D
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
G
K
----
A
V
V
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
PD
G
----------------
R
A
--
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
---
G
G
K-----
P
-----
P
L
--
E
R
V
A
--------
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
A
R
---------
84
PsiBlast_CBE
63.90
35%
-102
- C6 -
1EYE
2
DHPS1_MYCTU
A:
[8-272]
-----------------------------------------------
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
G
I
V
D
V
G
G
----------------
E
T
S
R
V
I
P
V
V
K
E
L
--
A
A
----
Q
G
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
R
A
-
D
-
P
A
M
G
P
L
L
A
E
--------
A
-
D
---------
V
P
W
V
L
M
H
W
R
A
V
S
A
D
T
-
P
H
V
-
P
V
R
Y
G
N
----------------------------
V
V
A
E
V
R
A
D
L
L
A
S
V
A
D
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
F
A
K
----
T
A
-
Q
H
N
W
A
I
L
H
A
L
P
E
L
V
-----
A
----------------
T
G
--
I
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
A--
G
P
------
D
GVMRP
T
D
--
G
R
D
T
--------
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
W
M
G
------------
74
PsiBlast_CBE
63.40
33%
-91
- C6 -
3TYU
1
?
A:
[4-278]
-----------------------------
M
H
L
T
A
R
-
G
L
T
L
-
D
LS
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
------
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
-
A
A
E
-
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
-
Q
-
E
-
P
G
A
L
E
A
A
A
K
--------
T
-
G
---------
L
P
V
C
L
M
H
M
Q
G
-----------
M
Q
H
S
P
Y
------------------------
Y
D
D
L
M
T
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
G
K
----
N
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
--
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
V
------
P
-----
P
Q
--
Q
R
V
I
--------
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
-------
T
R
S
A
----
81
PsiBlast_CBE
63.01
33%
-105
- C6 -
2VEG
2
DHPS_STRR6
A:
[9-300]
--------------------------------------------
K
T
V
I
C
G
I
I
N
V
T
P
---------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
-----
E
G
A
S
M
L
D
I
G
G
E
------
S
-
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
I
R
K
E
-----
S
D
V
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
V
N
D
I
T
G
L
-
M
G
D
-
E
K
M
P
H
V
V
A
E
A
R
A
Q
V
V
I
M
F
-
N
P
V
M
A
R
P
QHP
S
S
L
I
F
P
H
F
G
F
--
A
F
T
---
E
-
L
A
D
F
E
T
L
------------------------
P
--
I
E
E
L
M
E
A
F
F
E
R
A
L
A
R
A
A
E
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
F
G
L
----
T
K
-
K
E
N
L
L
L
L
R
D
L
D
K
L
H
-----
Q
----------------
K
G
--
Y
P
I
F
L
G
V
S
R
K
R
F
V
I
N
I
L
E
E
N
G
F
------
E
-----
V
N
--
P
E
T
E
L
G
F
R
N
R
D
T
A
S
A
H
V
T
S
I
A
A
R
Q
G
V
E
V
V
R
V
H
D
V
A
S
H
R
M
A
V
E
I
A
S
A
I
R
-------------
78
PsiBlast_CBE
60.62
35%
-90
- C6 -
2Y5S
9
?
B:
[13-277]
--------------------------------
C
G
R
F
E
L
T
F
-
E
--
R
P
L
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
-
P
-
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
L
------
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
-
R
-
Q
-
P
G
A
I
D
A
V
R
D
--------
G
-
N
---------
S
G
L
C
A
M
H
M
L
G
E
P
Q
T
M
-
Q
V
G
-
E
P
D
Y
G
D
V
------------------------
V
T
D
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
----
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
G
K
AVV
D
D
N
-
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
-----
P
----------------
D
G
RA
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G--
G
K
------
P
-----
P
L
--
E
R
V
A
--------
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
------------------------
79
PsiBlast_CBE
60.51
35%
-88
- C6 -
2Y5S
13
?
A:
[13-277]
--------------------------------
C
G
R
F
E
L
T
F
-
E
--
R
P
L
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
-
P
-
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
L
------
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
-
R
-
Q
-
P
G
A
I
D
A
V
R
D
--------
G
-
N
---------
S
G
L
C
A
M
H
M
L
G
E
P
Q
T
M
-
Q
V
G
-
E
P
D
Y
G
D
V
------------------------
V
T
D
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
----
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
G
K
AVV
D
D
N
-
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
-----
P
----------------
D
G
RA
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G--
G
K
------
P
-----
P
L
--
E
R
V
A
--------
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
------------------------
73
PsiBlast_CBE
60.17
33%
-108
- C6 -
3TYU
1
?
B:
[3-279]
----------------------------
H
M
H
L
T
A
R
-
G
L
T
L
-
D
LS
R
P
Q
V
M
G
I
L
N
------------
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
-----------------
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
-
Q
-
E
-
P
G
A
L
E
A
A
A
K
--------
T
-
G
---------
L
P
V
C
L
M
H
M
Q
--------------------------------------------
D
L
M
T
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
G
K
----
N
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
--
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
V
------
P
-----
P
Q
--
Q
R
V
I
--------
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
-------
T
R
S
A
K
---