@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1240: (2016-04-29 )
MSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPALQALEGVVMELDDCAFPLLSGVEIGSDPQKIFDGVSLALLVGARPRGAGMERSDLLEANGAIFTAQGKALNAVAADDVRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLDHNRAISQLAAKTGAAVTDIKKMTIWGNHSATQYPDLFHAEVAGKNAAEVVNDQAWIEDEFIPTVAKRGAAIIDARGASSAASAASATIDAARDWLLGTPADDWVSMAVVSDGSYGVPEGLISSFPVTTKGGNWTIVSGLEIDEFSRGRIDKSTAELADERSAVTELGLI
Atome Classification :
(29 SA)
.........10........20........30........40...--.....50........60........70.......-.80........90........100.......110.......120..-.....130.......140....-...150.......160.......170.......180.......190.......200..----.....210.......220.......230.......240.......250.......260.......270.-.-......280......-.290........300.......310.......320.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSAS
P
L
K
V
A
V
TGA
A
G
Q
I
G
Y
S
L
L
F
R
LASGSLLGPDR
P
I
E
L
R
L
L
EI--
E
P
A
L
Q
A
L
E
G
V
V
M
E
L
D
D
C
A
F
P
L
L
SGVEIGS
D
P
Q
K
I
-
F
DGV
S
L
A
L
L
VGARPRGAGM
E
R
S
D
L
LEANG
A
I
F
TAQGK
A
L
N
A
VAAD
D
-
V
R
V
GVTGNPAN
T
N
A
L
I
A
MTNAP-DI
P
R
E
R
F
S
A
L
T
RLD
H
N
R
A
I
S
Q
L
A
A
KTGA
A
V
T
D
I
K
K
M
T
I
WGNHSATQYPD
L
F
H
A
EVAGK----
N
A
A
E
V
VNDQAWIEDE
F
I
P
T
V
A
KR
G
A
A
I
I
DARGASSAASA
A
S
A
T
I
D
A
A
R
D
WLLGTPADD
W
V
S
M
A
V
VSD-G-S-YGV
P
E
G
L
I
SSFPVTT-KG-G
N
W
T
I
V
S
GLEI
D
E
FSRGRID
K
S
T
A
E
L
A
D
E
R
S
A
V
T
ELGLI
1
PsiBlast_PDB
98.47
99%
-92
- C4 -
4TVO
17
MDH_MYCTU
A:
[3-329]
--
A
S
P
L
K
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
L
A
S
G
S
L
L
G
P
D
R
P
I
E
L
R
L
L
E
I
--
E
P
A
L
Q
A
L
E
G
V
V
M
E
L
D
D
C
A
F
P
L
L
S
G
V
E
I
G
S
D
P
Q
K
I
-
F
D
G
V
S
L
A
L
L
V
G
A
R
P
R
G
A
G
M
E
R
S
D
L
L
E
A
N
G
A
I
F
T
A
Q
G
K
A
L
N
A
V
A
A
D
D
-
V
R
V
G
V
T
G
N
P
A
N
T
N
A
L
I
A
M
T
N
A
P
-
D
I
P
R
E
R
F
S
A
L
T
R
L
D
H
N
R
A
I
S
Q
L
A
A
K
T
G
A
A
V
T
D
I
K
K
M
T
I
W
G
N
H
S
A
T
Q
Y
P
D
L
F
H
A
E
V
A
G
K
----
N
A
A
E
V
V
N
D
Q
A
W
I
E
D
E
F
I
P
T
V
A
K
R
G
A
A
I
I
D
A
R
G
A
S
S
A
A
S
A
A
S
A
T
I
D
A
A
R
D
W
L
L
G
T
P
A
D
D
W
V
S
M
A
V
V
S
D
-
G
-
S
-
Y
G
V
P
E
G
L
I
S
S
F
P
V
T
T
-
K
G
-
G
N
W
T
I
V
S
G
L
E
I
D
E
F
S
R
G
R
I
D
K
S
T
A
E
L
A
D
E
R
S
A
V
T
E
L
G
L
I
49
HHSearch
98.05
100%
-91
- C4 -
4TVO
17
MDH_MYCTU
A:
[3-328]
--
A
S
P
L
K
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
L
A
S
G
S
L
L
G
P
D
R
P
I
E
L
R
L
L
E
I
--
E
P
A
L
Q
A
L
E
G
V
V
M
E
L
D
D
C
A
F
P
L
L
S
G
V
E
I
G
S
D
P
Q
K
I
-
F
D
G
V
S
L
A
L
L
V
G
A
R
P
R
G
A
G
M
E
R
S
D
L
L
E
A
N
G
A
I
F
T
A
Q
G
K
A
L
N
A
V
A
A
D
D
-
V
R
V
G
V
T
G
N
P
A
N
T
N
A
L
I
A
M
T
N
A
P
-
D
I
P
R
E
R
F
S
A
L
T
R
L
D
H
N
R
A
I
S
Q
L
A
A
K
T
G
A
A
V
T
D
I
K
K
M
T
I
W
G
N
H
S
A
T
Q
Y
P
D
L
F
H
A
E
V
A
G
K
----
N
A
A
E
V
V
N
D
Q
A
W
I
E
D
E
F
I
P
T
V
A
K
R
G
A
A
I
I
D
A
R
G
A
S
S
A
A
S
A
A
S
A
T
I
D
A
A
R
D
W
L
L
G
T
P
A
D
D
W
V
S
M
A
V
V
S
D
-
G
-
S
-
Y
G
V
P
E
G
L
I
S
S
F
P
V
T
T
-
K
G
-
G
N
W
T
I
V
S
G
L
E
I
D
E
F
S
R
G
R
I
D
K
S
T
A
E
L
A
D
E
R
S
A
V
T
E
L
G
L
-
21
PsiBlast_CBE
97.27
99%
-98
- C4 -
4TVO
12
MDH_MYCTU
B:
[4-329]
---
S
P
L
K
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
L
A
S
G
S
L
L
G
P
D
R
P
I
E
L
R
L
L
E
I
--
E
P
A
L
Q
A
L
E
G
V
V
M
E
L
D
D
C
A
F
P
L
L
S
G
V
E
I
G
S
D
P
Q
K
I
-
F
D
G
V
S
L
A
L
L
V
G
A
R
P
---------
L
L
E
A
N
G
A
I
F
T
A
Q
G
K
A
L
N
A
V
A
A
D
D
-
V
R
V
G
V
T
G
N
P
A
N
T
N
A
L
I
A
M
T
N
A
P
-
D
I
P
R
E
R
F
S
A
L
T
R
L
D
H
N
R
A
I
S
Q
L
A
A
K
T
G
A
A
V
T
D
I
K
K
M
T
I
W
G
N
H
S
A
T
Q
Y
P
D
L
F
H
A
E
V
A
G
K
----
N
A
A
E
V
V
N
D
Q
A
W
I
E
D
E
F
I
P
T
V
A
K
R
G
A
A
I
I
D
A
R
G
A
S
S
A
A
S
A
A
S
A
T
I
D
A
A
R
D
W
L
L
G
T
P
A
D
D
W
V
S
M
A
V
V
S
D
-
G
-
S
-
Y
G
V
P
E
G
L
I
S
S
F
P
V
T
T
-
K
G
-
G
N
W
T
I
V
S
G
L
E
I
D
E
F
S
R
G
R
I
D
K
S
T
A
E
L
A
D
E
R
S
A
V
T
E
L
G
L
I
6
PsiBlast_PDB
89.93
63%
-96
- C4 -
2CVQ
3
MDH_THETH
A:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
48
HHSearch
89.80
63%
-94
- C4 -
1Y7T
3
MDH_THETH
A:
[1-326]
-
M
K
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
-
5
PsiBlast_PDB
89.73
63%
-97
- C4 -
1Y7T
3
MDH_THETH
A:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
26
PsiBlast_CBE
89.64
63%
-97
- C4 -
1Y7T
3
MDH_THETH
B:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
2
PsiBlast_PDB
89.45
63%
-95
- C4 -
4KDE
-
MDH_THETH
A:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
30
PsiBlast_CBE
89.32
63%
-96
- C4 -
1WZE
1
MDH_THETH
B:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
G
S
--
E
R
S
F
Q
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
25
PsiBlast_CBE
89.18
63%
-97
- C4 -
2CVQ
3
MDH_THETH
B:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
27
PsiBlast_CBE
88.88
63%
-95
- C4 -
1BMD
1
MDH_THETH
B:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
D
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
7
PsiBlast_PDB
88.88
63%
-95
- C4 -
1BMD
1
MDH_THETH
A:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
D
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
29
PsiBlast_CBE
88.79
63%
-94
- C4 -
1WZI
1
MDH_THETH
B:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
G
S
--
E
R
S
F
Q
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
10
PsiBlast_PDB
88.48
63%
-94
- C4 -
1WZI
1
MDH_THETH
A:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
G
S
--
E
R
S
F
Q
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
9
PsiBlast_PDB
88.45
63%
-96
- C4 -
1WZE
1
MDH_THETH
A:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
G
S
--
E
R
S
F
Q
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
28
PsiBlast_CBE
88.24
63%
-97
- C4 -
1BDM
1
MDH_THETH
B:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
D
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
I
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
3
PsiBlast_PDB
88.01
63%
-97
- C4 -
4KDF
3
MDH_THETH
A:
[3-326]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
---------
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
-
4
PsiBlast_PDB
87.98
63%
-95
- C4 -
1IZ9
-
MDH_THETH
A:
[3-327]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
K
A
G
M
E
R
R
D
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
I
23
PsiBlast_CBE
87.43
63%
-97
- C4 -
4KDF
2
MDH_THETH
C:
[3-326]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
--------
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
-
22
PsiBlast_CBE
87.11
63%
-99
- C4 -
4KDF
2
MDH_THETH
D:
[3-326]
---
A
P
V
R
V
A
V
T
G
A
A
G
Q
I
G
Y
S
L
L
F
R
I
A
A
G
E
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
--
P
Q
A
M
K
A
L
E
G
V
V
M
E
L
E
D
C
A
F
P
L
L
A
G
L
E
A
T
D
D
P
K
V
A
-
F
K
D
A
D
Y
A
L
L
V
G
A
A
P
R
--------
L
L
Q
V
N
G
K
I
F
T
E
Q
G
R
A
L
A
E
V
A
K
K
D
-
V
K
V
L
V
V
G
N
P
A
N
T
N
A
L
I
A
Y
K
N
A
P
-
G
L
N
P
R
N
F
T
A
M
T
R
L
D
H
N
R
A
K
A
Q
L
A
K
K
T
G
T
G
V
D
R
I
R
R
M
T
V
W
G
N
H
S
S
T
M
F
P
D
L
F
H
A
E
V
D
G
R
----
P
A
L
E
L
V
-
D
M
E
W
Y
E
K
V
F
I
P
T
V
A
Q
R
G
A
A
I
I
Q
A
R
G
A
S
S
A
A
S
A
A
N
A
A
I
E
H
I
R
D
W
A
L
G
T
P
E
G
D
W
V
S
M
A
V
P
S
Q
-
G
-
E
-
Y
G
I
P
E
G
I
V
Y
S
F
P
V
T
A
-
K
D
-
G
A
Y
R
V
V
E
G
L
E
I
N
E
F
A
R
K
R
M
E
I
T
A
Q
E
L
L
D
E
M
E
Q
V
K
A
L
G
L
-
12
PsiBlast_PDB
85.56
58%
-88
- C4 -
1B8U
2
MDH_AQUAR
A:
[3-327]
--
K
T
P
M
R
V
A
V
T
G
A
A
G
Q
I
C
Y
S
L
L
F
R
I
A
N
G
D
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
PN
E
K
A
Q
K
A
L
Q
G
V
M
M
E
I
D
D
C
A
F
P
L
L
A
G
M
T
A
H
A
D
P
M
T
A
-
F
K
D
A
D
V
A
L
L
V
G
A
R
P
R
G
P
G
M
E
R
K
D
L
L
E
A
N
A
Q
I
F
T
V
Q
G
K
A
I
D
A
V
A
S
R
N
-
I
K
V
L
V
V
G
N
P
A
N
T
N
A
Y
I
A
M
K
S
A
P
-
S
L
P
A
K
N
F
T
A
M
L
R
L
D
H
N
R
A
L
S
Q
I
A
A
K
T
G
K
P
V
S
S
I
E
K
L
F
V
W
G
N
H
S
P
T
M
Y
A
D
Y
R
Y
A
Q
I
D
G
A
----
S
V
K
D
M
I
N
D
D
A
W
N
R
D
T
F
L
P
T
V
G
K
R
G
A
A
I
I
D
A
R
G
V
S
S
A
A
S
A
A
N
A
A
I
D
H
I
H
D
W
V
L
G
T
-
A
G
K
W
T
T
M
G
I
P
S
D
-
G
-
S
-
Y
G
I
P
E
G
V
I
F
G
F
P
V
T
T
-
E
N
-
G
E
Y
K
I
V
Q
G
L
S
I
D
A
F
S
Q
E
R
I
N
V
T
L
N
E
L
L
E
E
Q
N
G
V
Q
H
L
---
13
PsiBlast_PDB
84.88
58%
-88
- C4 -
1B8V
1
MDH_AQUAR
A:
[3-327]
--
K
T
P
M
R
V
A
V
T
G
A
A
G
Q
I
C
Y
S
L
L
F
R
I
A
N
G
D
M
L
G
K
D
Q
P
V
I
L
Q
L
L
E
I
PN
E
K
A
Q
K
A
L
Q
G
V
M
M
E
I
D
D
C
A
F
P
L
L
A
G
M
T
A
H
A
D
P
M
T
A
-
F
K
D
A
D
V
A
L
L
V
G
A
R
P
R
G
P
G
M
E
R
K
D
L
L
E
A
N
A
Q
I
F
T
V
Q
G
K
A
I
D
A
V
A
S
R
N
-
I
K
V
L
V
V
G
N
P
A
N
T
N
A
Y
I
A
M
K
S
A
P
-
S
L
P
A
K
N
F
T
A
M
L
R
L
D
H
N
R
A
L
S
Q
I
A
A
K
T
G
K
P
V
S
S
I
E
K
L
F
V
W
G
N
H
S
P
T
M
Y
A
D
Y
R
Y
A
Q
I
D
G
A
----
S
V
K
D
M
I
N
D
D
A
W
N
R
D
T
F
L
P
T
V
G
K
R
G
A
A
I
I
D
A
R
G
V
S
S
A
A
S
A
A
N
A
A
I
D
H
I
H
D
W
V
L
G
T
-
A
G
K
W
T
T
M
G
I
P
S
D
-
G
-
S
-
Y
G
I
P
E
G
V
I
F
G
F
P
V
T
T
-
E
N
-
G
E
Y
K
I
V
Q
G
L
S
I
D
A
F
S
Q
E
R
I
N
V
T
L
N
E
L
L
E
E
Q
N
G
V
Q
H
L
---
32
PsiBlast_CBE
83.28
52%
-83
- C4 -
5MDH
2
MDHC_PIG
B:
[1-329]
--
S
E
P
I
R
V
L
V
T
G
A
A
G
Q
I
A
Y
S
L
L
Y
S
I
G
N
G
S
V
F
G
K
D
Q
P
I
I
L
V
L
L
D
I
--
T
P
M
M
G
V
L
D
G
V
L
M
E
L
Q
D
C
A
L
P
L
L
K
D
V
-
I
A
T
D
K
E
E
I
A
F
K
D
L
D
V
A
I
L
V
G
S
M
P
R
R
D
G
M
E
R
K
D
L
L
K
A
N
V
K
I
F
K
C
Q
G
A
A
L
D
K
Y
A
K
K
S
-
V
K
V
I
V
V
G
N
P
A
N
T
N
C
L
T
A
S
K
S
A
P
-
S
I
P
K
E
N
F
S
C
L
T
R
L
D
H
N
R
A
K
A
Q
I
A
L
K
L
G
V
T
S
D
D
V
K
N
V
I
I
W
G
N
H
S
S
T
Q
Y
P
D
V
N
H
A
K
V
K
L
Q
AKEV
G
V
Y
E
A
V
K
D
D
S
W
L
K
G
E
F
I
T
T
V
Q
Q
R
G
A
A
V
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
I
C
D
H
V
R
D
I
W
F
G
T
P
E
G
E
F
V
S
M
G
I
I
S
D
-
G
N
S
-
Y
G
V
P
D
D
L
L
Y
S
F
P
V
T
I
-
K
D
-
K
T
W
K
I
V
E
G
L
P
I
N
D
F
S
R
E
K
M
D
L
T
A
K
E
L
A
E
E
K
E
T
A
F
E
F
---
16
PsiBlast_PDB
82.59
52%
-87
- C4 -
4MDH
3
MDHC_PIG
A:
[1-329]
--
S
E
P
I
R
V
L
V
T
G
A
A
G
Q
I
A
Y
S
L
L
Y
S
I
G
N
G
S
V
F
G
K
D
Q
P
I
I
L
V
L
L
D
I
--
T
P
M
M
G
V
L
D
G
V
L
M
E
L
Q
D
C
A
L
P
L
L
K
D
V
-
I
A
T
D
K
E
E
I
A
F
K
D
L
D
V
A
I
L
V
G
S
M
P
R
R
D
G
M
E
R
K
D
L
L
K
A
N
V
K
I
F
K
C
Q
G
A
A
L
D
K
Y
A
K
K
S
-
V
K
V
I
V
V
G
N
P
A
N
T
N
C
L
T
A
S
K
S
A
P
-
S
I
P
K
E
N
F
S
C
L
T
R
L
D
H
N
R
A
K
A
Q
I
A
L
K
L
G
V
T
S
D
D
V
K
N
V
I
I
W
G
N
H
S
S
T
Q
Y
P
D
V
N
H
A
K
V
K
L
Q
A
K
E
V
G
V
Y
E
A
V
K
D
D
S
W
L
K
G
E
F
I
T
T
V
Q
Q
R
G
A
A
V
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
I
C
D
H
V
R
D
I
W
F
G
T
P
E
G
E
F
V
S
M
G
I
I
S
D
-
G
N
S
-
Y
G
V
P
D
D
L
L
Y
S
F
P
V
T
I
-
K
D
-
K
T
W
K
I
V
E
G
L
P
I
N
D
F
S
R
E
K
M
D
L
T
A
K
E
L
A
E
E
K
E
T
A
F
E
F
---
17
PsiBlast_PDB
82.50
50%
-86
- C4 -
1CIV
1
MDHP_FLABI
A:
[43-365]
-----
I
N
V
A
V
S
G
A
A
G
M
I
S
N
H
L
L
F
K
L
A
S
G
E
V
F
G
P
D
Q
P
I
S
L
K
L
L
G
S
--
E
R
S
F
A
A
L
E
G
V
A
M
E
L
E
D
S
L
Y
P
L
L
R
Q
V
S
I
G
I
D
P
Y
E
I
-
F
Q
D
A
E
W
A
L
L
I
G
A
K
P
R
G
P
G
M
E
R
A
D
L
L
D
I
N
G
Q
I
F
A
E
Q
G
K
A
L
N
A
V
A
S
P
N
-
V
K
V
M
V
V
G
N
P
C
N
T
N
A
L
I
C
L
K
N
A
P
-
N
I
P
P
K
N
F
H
A
L
T
R
L
D
E
N
R
A
K
C
Q
L
A
L
K
A
G
V
F
Y
D
K
V
S
N
V
T
I
W
G
N
H
S
T
T
Q
V
P
D
F
L
N
A
K
I
H
G
I
----
P
V
T
E
V
I
R
D
R
K
W
L
E
D
E
F
T
N
M
V
Q
T
R
G
G
V
L
I
K
K
W
G
R
S
S
A
A
S
T
A
V
S
I
V
D
A
I
R
S
L
V
T
P
T
P
E
G
D
W
F
S
T
G
V
Y
T
N
-
G
-
N
P
Y
G
I
A
E
D
I
V
F
S
M
P
C
R
S
-
K
G
D
G
D
Y
E
F
V
K
D
V
I
F
D
D
Y
L
S
K
K
I
K
K
S
E
D
E
L
L
A
E
K
K
C
V
A
H
L
---
15
PsiBlast_PDB
82.44
52%
-78
- C4 -
5MDH
2
MDHC_PIG
A:
[1-329]
--
S
E
P
I
R
V
L
V
T
G
A
A
G
Q
I
A
Y
S
L
L
Y
S
I
G
N
G
S
V
F
G
K
D
Q
P
I
I
L
V
L
L
D
I
--
T
P
M
M
G
V
L
D
G
V
L
M
E
L
Q
D
C
A
L
P
L
L
K
D
V
-
I
A
T
D
K
E
E
I
A
F
K
D
L
D
V
A
I
L
V
G
S
M
P
R
R
D
G
M
E
R
K
D
L
L
K
A
N
V
K
I
F
K
C
Q
G
A
A
L
D
K
Y
A
K
K
S
-
V
K
V
I
V
V
G
N
P
A
N
T
N
C
L
T
A
S
K
S
A
P
-
S
I
P
K
E
N
F
S
C
L
T
R
L
D
H
N
R
A
K
A
Q
I
A
L
K
L
G
V
T
S
D
D
V
K
N
V
I
I
W
G
N
H
S
S
T
Q
Y
P
D
V
N
H
A
K
V
K
L
Q
A
K
E
V
G
V
Y
E
A
V
K
D
D
S
W
L
K
G
E
F
I
T
T
V
Q
Q
R
G
A
A
V
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
I
C
D
H
V
R
D
I
W
F
G
T
P
E
G
E
F
V
S
M
G
I
I
S
D
-
G
N
S
-
Y
G
V
P
D
D
L
L
Y
S
F
P
V
T
I
-
K
D
-
K
T
W
K
I
V
E
G
L
P
I
N
D
F
S
R
E
K
M
D
L
T
A
K
E
L
A
E
E
K
E
T
A
F
E
F
---
33
PsiBlast_CBE
81.44
52%
-88
- C4 -
4MDH
3
MDHC_PIG
B:
[1-329]
--
S
E
P
I
R
V
L
V
T
G
A
A
G
Q
I
A
Y
S
L
L
Y
S
I
G
N
G
S
V
F
G
K
D
Q
P
I
I
L
V
L
L
D
I
--
T
P
M
M
G
V
L
D
G
V
L
M
E
L
Q
D
C
A
L
P
L
L
K
D
V
-
I
A
T
D
K
E
E
I
A
F
K
D
L
D
V
A
I
L
V
G
S
M
P
R
R
D
G
M
E
R
K
D
L
L
K
A
N
V
K
I
F
K
C
Q
G
A
A
L
D
K
Y
A
K
K
S
-
V
K
V
I
V
V
G
N
P
A
N
T
N
C
L
T
A
S
K
S
A
P
-
S
I
P
K
E
N
F
S
C
L
T
R
L
D
H
N
R
A
K
A
Q
I
A
L
K
L
G
V
T
S
D
D
V
K
N
V
I
I
W
G
N
H
S
S
T
Q
Y
P
D
V
N
H
A
K
V
K
L
Q
AKEV
G
V
Y
E
A
V
K
D
D
S
W
L
K
G
E
F
I
T
T
V
Q
Q
R
G
A
A
V
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
I
C
D
H
V
R
D
I
W
F
G
T
P
E
G
E
F
V
S
M
G
I
I
S
D
-
G
N
S
-
Y
G
V
P
D
D
L
L
Y
S
F
P
V
T
I
-
K
D
-
K
T
W
K
I
V
E
G
L
P
I
N
D
F
S
R
E
K
M
D
L
T
A
K
E
L
A
E
E
K
E
T
A
F
E
F
---
61
HHSearch
81.03
52%
-75
* C4 *
5MDH
2
MDHC_PIG
A:
[1-331]
--
S
E
P
I
R
V
L
V
T
G
A
A
G
Q
I
A
Y
S
L
L
Y
S
I
G
N
G
S
V
F
G
K
D
Q
P
I
I
L
V
L
L
D
I
--
T
P
M
M
G
V
L
D
G
V
L
M
E
L
Q
D
C
A
L
P
L
L
K
D
V
I
A
T
D
K
E
E
I
A
-
F
K
D
L
D
V
A
I
L
V
G
S
M
P
R
R
D
G
M
E
R
K
D
L
L
K
A
N
V
K
I
F
K
C
Q
G
A
A
L
D
K
Y
A
-
K
K
S
V
K
V
I
V
V
G
N
P
A
N
T
N
C
L
T
A
S
K
S
A
P
-
S
I
P
K
E
N
F
S
C
L
T
R
L
D
H
N
R
A
K
A
Q
I
A
L
K
L
G
V
T
S
D
D
V
K
N
V
I
I
W
G
N
H
S
S
T
Q
Y
P
D
V
N
H
A
K
V
K
L
Q
A
K
E
V
G
V
Y
E
A
V
K
D
D
S
W
L
K
G
E
F
I
T
T
V
Q
Q
R
G
A
A
V
I
K
A
R
K
L
S
S
A
M
S
A
A
K
A
I
C
D
H
V
R
D
I
W
F
G
T
P
E
G
E
F
V
S
M
G
I
I
S
D
-
G
N
S
-
Y
G
V
P
D
D
L
L
Y
S
F
P
V
T
I
K
D
K
-
T
W
K
I
V
E
-
G
L
P
I
N
D
F
S
R
E
K
M
D
L
T
A
K
E
L
A
E
E
K
E
T
A
F
E
F
L
S
-
20
PsiBlast_PDB
79.66
54%
-83
- C4 -
4I1I
6
?
A:
[21-341]
-
S
M
S
A
V
K
V
A
V
T
G
A
A
G
Q
I
G
Y
A
L
V
P
L
I
A
R
G
A
L
L
G
P
T
T
P
V
E
L
R
L
L
D
I
--
E
P
A
L
K
A
L
A
G
V
E
A
E
L
E
D
C
A
F
P
L
L
D
K
V
V
V
T
A
D
P
R
V
A
-
F
D
G
V
A
I
A
I
M
C
G
A
F
P
R
K
A
G
M
E
R
K
D
L
L
E
M
N
A
R
I
F
K
E
Q
G
E
A
I
A
A
V
A
A
S
D
-
C
R
V
V
V
V
G
N
P
A
N
T
N
A
L
I
L
L
K
S
A
Q
G
K
L
N
P
R
H
V
T
A
M
T
R
L
D
H
N
R
A
L
S
L
L
A
R
K
A
G
V
P
V
S
Q
V
R
N
V
I
I
W
G
N
H
S
S
T
Q
V
P
D
T
D
S
A
V
I
G
T
T
----
P
A
R
E
A
I
K
D
-------
F
V
Q
V
V
R
G
R
G
A
E
I
I
Q
L
R
G
L
S
S
A
M
S
A
A
K
A
A
V
D
H
V
H
D
W
I
H
G
T
P
E
G
V
Y
V
S
M
G
V
Y
S
D
E
N
-
P
-
Y
G
V
P
S
G
L
I
F
S
F
P
C
T
C
-
H
A
-
G
E
W
T
V
V
S
G
K
L
N
G
D
L
G
K
Q
R
L
A
S
T
I
A
E
L
Q
E
E
R
A
--------