@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1253: (2016-04-29 )
MAFPEYSPAASAATFADLQIHPRVLRAIGDVGYESPTAIQAATIPALMAGSDVVGLAQTGTGKTAAFAIPMLSKIDITSKVPQALVLVPTRELALQVAEAFGRYGAYLSQLNVLPIYGGSSYAVQLAGLRRGAQVVVGTPGRMIDHLERATLDLSRVDFLVLDEADEMLTMGFADDVERILSETPEYKQVALFSATMPPAIRKLSAKYLHDPFEVTCKAKTAVAENISQSYIQVARKMDALTRVLEVEPFEAMIVFVRTKQATEEIAEKLRARGFSAAAISGDVPQAQRERTITALRDGDIDILVATDVAARGLDVERISHVLNYDIPHDTESYVHRIGRTGRAGRSGAALIFVSPRELHLLKAIEKATRQTLTEAQLPTVEDVNTQRVAKFADSITNALGGPGIELFRRLVEEYEREHDVPMADIAAALAVQCRGGEAFLMAPDPPLSRRNRDQRRDRPQRPKRRPDLTTYRVAVGKRHKIGPGAIVGAIANEGGLHRSDFGQIRIGPDFSLVELPAKLPRATLKKLAQTRISGVLIDLRPYRPPDAARRHNGGKPRRKHVG
Atome Classification :
(68 SA)
.........10......-..20.......-.30........40........50-.-........60........70..---..-----...------------------.---------80-----...-.....90...---.....100.......110.......120.......-130..----......140.....-..150-.-........160.......-170.-.......180----...----.----.-...190.......200.......210.......220........230.--...---.---.---...240.....----------.-.250.-......260.......270.......280.......290.......300.......310.......320......------.------330.......340.......350..-....-.360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAFPEYSPAASA
A
T
F
A
D
-
L
Q
I
H
P
R
V
L
R
A
I
-
G
DVGYESPTAIQ
A
A
T
I
P
A
L
MAG--S-
D
V
V
G
L
A
QTGTGK
T
A
A
F
A
I
P
M
L
S
---KI-----DIT------------------S---------KV-----P
Q
A
-
L
V
L
V
P
T
R
E
L
A
---
L
Q
V
A
E
A
F
G
R
Y
G
A
Y
L
S
QL
N
V
L
P
IYGGS
S
Y
A
V
Q
L
A
GL-R-RG
A
----
Q
V
V
VGT
P
G
R
M
I
D
H
L
-
E
R
A
---
T
-LDLSR
V
D
F
L
V
LDEAD
E
M
L-TM-G-
F
A
D
D
V
E
R
I
L
-----SET----P----E-Y
K
Q
V
A
L
FSATM
P
P
A
I
R
K
L
S
A
K
YLHDP
F
E
V
T
C
K
A
K
T
-
A
V
A
E
N
I
S
Q
S
--
Y
--
I
Q
V
---
A
---
R
---
K
M
D
A
L
T
R
V
LEV----------E-PF
E
A
M
-
I
V
F
V
R
T
K
Q
A
T
E
E
I
A
E
K
L
R
ARGF
S
A
AAISGDVP
Q
A
Q
R
ER
T
I
T
A
LRDG
D
I
D
I
L
V
ATDVAARGL
D
V
E
R
I
S
H
V
LNYDIP------H------D
T
E
S
Y
V
H
R
IGRTGRAGRS
G
A
A
L
I
F
V-S
P
R
E
-
L
H
L
L
K
A
I
E
K
A
T
R
Q
T
L
T
EAQLPTVEDV
N
T
Q
R
V
A
K
F
A
D
S
I
T
N
ALGG
P
G
I
E
L
F
R
R
L
V
E
E
Y
E
R
EHDV
P
M
A
D
I
A
A
A
L
A
V
Q
CRG
G
E
A
F
L
MAPDPPLSRR
N
R
D
Q
RRDRPQRPKRRPDL
T
T
Y
R
V
AVGKRHKIGPG
A
I
V
G
A
IANEGGLHRSDFG
Q
I
R
IGPDF
S
L
V
ELPAKL
P
R
A
T
L
K
K
L
A
Q
T
RIS
G
V
L
I
DLRPYRP
P
D
A
A
RRHNGGKPRRKHVG
134
HHSearch
90.63
43%
-117
- C3 -
1HV8
5
H669_METJA
A:
[4-363]
----------
E
Y
M
N
F
N
E
-
L
N
L
S
D
N
I
L
N
A
I
-
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
D
E-
Y
-
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
---
L
V
-----
N
E
N
----------------------------
N
G
-----
I
E
A
-
I
I
L
T
P
T
R
E
L
A
---
I
Q
V
A
D
E
I
E
S
L
K
G
N
K
-
N
L
K
I
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
K
-
A
-
L
-
K
N
A
----
N
I
V
V
G
T
P
G
R
I
L
D
H
I
-
N
R
G
---
T
-
L
N
L
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
-
N
M
-
G
-
F
I
K
D
V
E
K
I
L
-----
N
A
C
----
N
----
K
-
D
K
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
F
I
K
A
K
-----
I
N
A
N
I
E
Q
S
--
Y
--
V
E
V
N
E-
N
---
E
---
R
F
E
A
L
C
R
L
L
K
N
------------
K
E
F
Y
G
-
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
------
Q
------
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
-
N
R
R
E
-
Y
K
K
L
R
Y
I
E
R
A
M
K
L
K
I
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.14
42%
-123
- C3 -
1HV8
5
H669_METJA
A:
[7-356]
-------------
N
F
N
E
-
L
N
L
S
D
N
I
L
N
A
I
-
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
D
--
E
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
---
L
V
-----
N
E
N
------------------
N
---------
G
I
------
E
A
-
I
I
L
T
P
T
R
E
L
A
---
I
Q
V
A
D
E
I
E
S
L
K
G
N
-
K
N
L
K
I
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
K
A
L
-
K
--
N
A
----
N
I
V
V
G
T
P
G
R
I
L
D
H
I
-
N
R
G
---
T
-
L
N
L
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
-
N
M
-
G
-
F
I
K
D
V
E
K
I
L
-----
N
A
C
----
N
----
K
-
D
K
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
F
I
----
K
A
-
K
I
N
A
N
I
E
Q
S
--
Y
--
V
E
V
---
N
---
E
NE-
R
F
E
A
L
C
R
L
L
K
N
----------
K
-
E
F
Y
G
L
--
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
------
Q
------
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
-
N
R
R
E
-
Y
K
K
L
R
Y
I
E
R
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
89.30
44%
-108
- C3 -
4KBF
3
?
A:
[1-361]
------------
M
E
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
QER---------------
G
---------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
A
V
A
P
H
---
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
D
E
-
P
V
T
Y
E
E
E
A
V
--
P
--
A
P
V
---
R
---
G
---
R
L
E
V
L
S
D
L
L
Y
V
----------
A
-
S
P
D
R
A
-
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
-
G
P
R
E
-
R
R
D
V
E
A
L
E
R
A
V
G
R
R
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.24
44%
-110
- C3 -
4KBF
3
?
A:
[3-357]
--------------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
------------------
Q
ERG------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
D
E
-
P
V
T
Y
E
E
E
A
V
--
P
--
A
P
V
---
R
---
G
---
R
L
E
V
L
S
D
L
L
Y
V
----------
A
-
S
P
D
R
A
-
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
-
G
P
R
E
-
R
R
D
V
E
A
L
E
R
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
89.03
37%
-120
- C3 -
2I4I
1
DDX3X_HUMAN
A:
[12-392]
---------
P
H
I
E
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
-----
Y
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
---------
Q
Y
-----
P
I
S
-
L
V
L
A
P
T
R
E
L
A
---
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
-
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
G
C
----
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
G
---
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
-----
E
Q
D
TMPP
K
----
G
-
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-----
T
S
E
N
I
T
Q
K
--
V
--
V
W
V
---
E
ES-
D
---
K
R
S
F
L
L
D
L
L
N
A
T---------
G
-
K
D
S
L
T
-
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
-
N
E
R
N
-
I
N
I
T
K
D
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
88.94
44%
-113
- C3 -
4KBG
4
?
B:
[3-357]
--------------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
------------------
Q
ERG------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
D
E
-
P
V
T
Y
E
E
E
A
V
--
P
--
A
P
V
---
R
---
G
---
R
L
E
V
L
S
D
L
L
Y
V
----------
A
-
S
P
D
R
A
-
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
-
G
P
R
E
-
R
R
D
V
E
A
L
E
R
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
88.86
44%
-118
- C3 -
4KBF
1
?
B:
[3-357]
--------------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
------------------
Q
ERG------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
D
E
-
P
V
T
Y
E
E
E
A
V
--
P
--
A
P
V
---
R
---
G
---
R
L
E
V
L
S
D
L
L
Y
V
----------
A
-
S
P
D
R
A
-
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
-
G
P
R
E
-
R
R
D
V
E
A
L
E
R
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
88.30
37%
-109
- C3 -
4PXA
5
DDX3X_HUMAN
A:
[61-443]
--------
P
P
H
I
E
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
-----
Y
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
---------
Q
Y
-----
P
I
S
-
L
V
L
A
P
T
R
E
L
A
---
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
-
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
G
C
----
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
G
---
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
V
M
-
G
-
F
E
P
Q
I
R
R
I
V
-----
E
Q
D
----
T
MPPK
G
-
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
V
G
-
S
T
S
E
N
I
T
Q
K
--
V
--
V
W
V
---
E
ES-
D
---
K
R
S
F
L
L
D
L
L
N
A
----------
T
G
K
D
S
L
T
-
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
-
N
E
R
N
-
I
N
I
T
K
D
L
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
87.02
37%
-120
- C3 -
3EIQ
-
IF4A1_HUMAN
A:
[26-395]
------
N
W
N
E
I
V
D
S
F
D
D
-
M
N
L
S
E
S
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
L
P
C
I
K
G
--
Y
-
D
V
I
A
Q
A
Q
S
G
T
G
K
T
A
T
F
A
I
S
I
L
Q
---
Q
I
-----
E
L
D
------------------
L
---------
K
A
-----
T
Q
A
-
L
V
L
A
P
T
R
E
L
A
---
Q
Q
I
Q
K
V
V
M
A
L
G
D
Y
M
-
G
A
S
C
H
A
C
I
G
G
T
N
V
R
A
E
V
Q
K
L
Q
M
-
E
A
P
----
H
I
I
V
G
T
P
G
R
V
F
D
M
L
-
N
R
R
---
Y
-
L
S
P
K
Y
I
K
M
F
V
L
D
E
A
D
E
M
L
-
S
R
-
G
-
F
K
D
Q
I
Y
D
I
F
-----
Q
K
L
----
N
----
S
-
N
T
Q
V
V
L
L
S
A
T
M
P
S
D
V
L
E
V
T
K
K
F
M
R
D
P
I
R
I
L
V
K
K
E
E
-
L
T
L
E
G
I
R
Q
F
--
Y
--
I
N
V
---
E
REE
W
---
K
L
D
T
L
C
D
L
Y
E
T
----------
L
-
T
I
T
Q
A
-
V
I
F
I
N
T
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
F
T
V
S
A
M
---
M
D
Q
K
E
R
D
V
I
M
R
E
F
R
S
G
---
V
L
I
T
T
D
L
L
A
--
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
T
------
N
R
E
N
Y
I
H
R
I
G
R
G
-------
V
A
I
N
M
V
-
T
E
E
D
-
K
R
T
L
R
D
I
E
T
F
Y
N
T
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
86.99
36%
-102
- C3 -
4D25
4
?
A:
[44-423]
------
N
P
P
R
P
I
E
S
F
E
T
-
A
N
L
R
K
Y
V
L
D
N
V
-
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
--
R
-
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
---
M
L
L
Q
D
PK
D
L
I
------------------
S
---------
E
N
G
C
A
Q
-
P
Q
V
-
I
I
V
S
P
T
R
E
L
T
---
L
Q
I
F
N
E
-
A
R
K
F
S
Y
G
S
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
-
R
G
C
----
H
I
L
V
A
T
P
G
R
L
H
D
F
V
-
E
R
N
---
R
-
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
M
-
G
-
F
M
P
S
I
E
K
M
M
L
HPTM
V
E
T
----
T
----
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
-
G
A
S
T
D
V
E
Q
I
--
F
--
I
E
V
---
T
---
K
YE-
K
R
N
S
L
K
Q
L
I
E
E
----------
N
-
D
G
K
R
I
-
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
D
-
L
A
L
V
A
D
L
S
K
I
L
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
86.91
33%
-123
- C3 -
4LJY
4
PRP5_YEAST
A:
[45-437]
-------
C
P
K
P
V
T
K
W
S
Q
-
L
G
L
S
T
D
T
M
V
L
I
T
E
K
L
H
F
G
S
L
T
P
I
Q
S
Q
A
L
P
A
I
M
S
G
--
R
-
D
V
I
G
I
S
K
T
G
S
G
K
T
I
S
Y
L
L
P
L
L
R
---
Q
V
-----
K
A
Q
------------------
R
PLSKHE---
T
G
-----
P
M
G
-
L
I
L
A
P
T
R
E
L
A
---
L
Q
I
H
E
E
V
T
K
F
T
E
A
D
T
S
I
R
S
V
C
C
T
G
G
S
E
M
K
K
Q
I
T
D
L
-
K
-
R
G
T
----
E
I
V
V
A
T
P
G
R
F
I
D
I
L
-
T
L
N
DGK
L
-
L
S
T
K
R
I
T
F
V
V
M
D
E
A
D
R
L
F
-
D
L
-
G
-
F
E
P
Q
I
T
Q
I
M
-----
K
T
V
----
R
----
P
-
D
K
Q
C
V
L
F
S
A
T
F
P
N
K
L
R
S
F
A
V
R
V
L
H
S
P
I
S
I
T
I
N
S
K
G
-
M
V
N
E
N
V
K
Q
K
--
F
--
R
I
C
---
H
S
E
D
E
---
K
F
D
N
L
V
Q
L
I
H
E
R
S
E
F
F
D
E
V
Q
S---
D
A
K
A
-
I
I
F
V
S
S
Q
N
I
C
D
F
I
S
K
K
L
L
N
A
G
I
V
T
C
A
I
H
A
G
K
P
Y
Q
E
R
L
M
N
L
E
K
F
K
R
E
K
N
S
I
L
L
C
T
E
V
L
S
R
G
L
N
V
P
E
V
S
L
V
I
I
Y
N
A
V
------
K
------
T
F
A
Q
Y
V
H
T
T
G
R
T
A
R
G
S
R
S
G
T
A
I
T
L
L
-
L
H
D
E
-
L
S
G
A
Y
I
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
86.75
37%
-116
- C3 -
2J0S
3
IF4A3_HUMAN
A:
[38-393]
-------------
T
F
D
T
-
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
-----
D
I
Q
------------------
V
---------
R
E
-----
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
---
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
N
-
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
-
Y
G
Q
----
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
R
---
S
-
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
-----
R
Y
L
----
P
----
P
-
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
-
L
T
L
E
G
I
K
Q
F
--
F
--
V
A
V
---
E
---
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
----------
L
-
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.52
37%
-114
- C3 -
3EX7
4
IF4A3_HUMAN
C:
[39-394]
-------------
T
F
D
T
-
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
-----
D
I
Q
------------------
V
---------
R
E
-----
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
---
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
N
-
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
-
Y
G
Q
----
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
R
---
S
-
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
-----
R
Y
L
----
P
----
P
-
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
-
L
T
L
E
G
I
K
Q
F
--
F
--
V
A
V
---
E
---
R
EEW
K
F
D
T
L
C
D
L
Y
D
T
----------
L
-
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
86.51
36%
-99
- C3 -
4D26
4
?
A:
[44-423]
------
N
P
P
R
P
I
E
S
F
E
T
-
A
N
L
R
K
Y
V
L
D
N
V
-
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
--
R
-
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
---
M
L
L
Q
D
P
K
D
L
I
------------------
S
---------
E
N
G
C
A
Q
-
P
Q
V
-
I
I
V
S
P
T
R
E
L
T
---
L
Q
I
F
N
E
-
A
R
K
F
S
Y
G
S
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
-
R
G
C
----
H
I
L
V
A
T
P
G
R
L
H
D
F
V
-
E
R
N
---
R
-
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
M
-
G
-
F
M
P
S
I
E
K
M
M
L
HPTM
V
E
T
----
T
----
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
-
G
A
S
T
D
V
E
Q
I
--
F
--
I
E
V
---
T
---
K
YE-
K
R
N
S
L
K
Q
L
I
E
E
----------
N
-
D
G
K
R
I
-
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
D
-
L
A
L
V
A
D
L
S
K
I
L
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.50
37%
-114
- C3 -
2XB2
4
IF4A3_HUMAN
A:
[39-394]
-------------
T
F
D
T
-
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
-----
D
I
Q
------------------
V
---------
R
E
-----
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
---
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
N
-
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
-
Y
G
Q
----
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
R
---
S
-
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
-----
R
Y
L
----
P
----
P
-
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
-
L
T
L
E
G
I
K
Q
F
--
F
--
V
A
V
---
E
---
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
----------
L
-
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
86.42
32%
-122
- C3 -
4CT4
2
DDX6_HUMAN
D:
[7-360]
--------------
F
E
D
-
Y
C
L
K
R
E
L
L
M
G
I
-
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
---
R
L
-----
D
L
K
------------------
K
---------
D
N
-----
I
Q
A
-
M
V
I
V
P
T
R
E
L
A
---
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
-
D
-
D
T
V
----
H
V
V
I
A
T
P
G
R
I
L
D
L
I
-
K
K
G
---
V
-
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
-----
L
T
L
----
P
----
K
-
N
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
E
E
L
-
T
L
-
K
G
V
T
Q
Y
--
Y
--
A
Y
V
---
T
ER-
Q
---
K
V
H
C
L
N
T
L
F
S
R
----------
L
-
Q
I
N
Q
S
-
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
----
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
-
T
Y
D
D
-
R
F
N
L
K
S
I
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.41
37%
-115
- C3 -
2HYI
3
IF4A3_HUMAN
C:
[39-394]
-------------
T
F
D
T
-
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
-----
D
I
Q
------------------
V
---------
R
E
-----
T
Q
A
-
L
I
L
A
P
T
R
E
L
A
---
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
N
-
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
-
Y
G
Q
----
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
R
R
---
S
-
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
-----
R
Y
L
----
P
----
P
-
A
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
-
L
T
L
E
G
I
K
Q
F
--
F
--
V
A
V
---
E
---
R
E
E
W
K
F
D
T
L
C
D
L
Y
D
T
----------
L
-
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
-
I
R
I
L
R
D
I
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
86.39
34%
-126
- C3 -
3EWS
1
DD19B_HUMAN
A:
[56-427]
------
S
P
L
Y
S
V
K
S
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
-----
E
P
A
------------------
N
---------
K
Y
-----
P
Q
C
-
L
C
L
S
P
T
Y
E
L
A
---
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
E
L
K
L
-------
A
Y
A
V
R
G
N
K
L
-
E
-
R
G
Q
KISE
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
K
L
---
K
F
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
-----
R
M
L
----
P
----
R
-
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
-
E
T
L
D
T
I
K
Q
Y
--
Y
--
V
L
C
---
S
S
R
D
E
---
K
F
Q
A
L
C
N
L
Y
G
A
----------
I
-
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
D
KDGNP
D
N
E
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
-
M
N
I
L
N
R
I
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
86.37
32%
-122
- C3 -
5ANR
-
DDX6_HUMAN
B:
[96-454]
------------
N
E
F
E
D
-
Y
C
L
K
R
E
L
L
M
G
I
-
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
---
R
L
-----
D
L
K
------------------
K
---------
D
N
-----
I
Q
A
-
M
V
I
V
P
T
R
E
L
A
---
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
-
D
-
D
T
V
----
H
V
V
I
A
T
P
G
R
I
L
D
L
I
-
K
K
G
---
V
-
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
-----
L
T
L
----
P
----
K
-
N
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
E
E
L
--
T
L
K
G
V
T
Q
Y
--
Y
--
A
Y
V
TE-
R
---
Q
---
K
V
H
C
L
N
T
L
F
S
R
----------
L
-
Q
I
N
Q
S
-
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
----
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
L
A
E
T
Y
L
H
R
I
G
R
S
G
----
L
G
L
A
I
N
L
I
-
T
Y
D
D
-
R
F
N
L
K
S
I
E
E
Q
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
86.35
36%
-102
- C3 -
4D25
4
?
A:
[44-419]
------
N
P
P
R
P
I
E
S
F
E
T
-
A
N
L
R
K
Y
V
L
D
N
V
-
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
--
R
-
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
---
M
L
-----
L
Q
D
------------------
P
KD
L
I
S
E
NG
C
A
Q
-----
P
Q
V
-
I
I
V
S
P
T
R
E
L
T
---
L
Q
I
F
N
E
A
R
K
F
S
Y
G
S
-
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
-
R
G
C
----
H
I
L
V
A
T
P
G
R
L
H
D
F
V
-
E
R
N
---
R
-
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
M
-
G
-
F
M
P
S
I
E
K
M
M
-----
L
H
P
TMVE
T
----
T
-
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
-
G
A
S
T
D
V
E
Q
I
--
F
--
I
E
V
---
T
KY-
E
---
K
R
N
S
L
K
Q
L
I
E
E
----------
N
-
D
G
K
R
I
-
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
-
D
S
D
Q
D
L
A
L
V
A
D
L
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
85.46
35%
-114
- C3 -
2I4I
1
DDX3X_HUMAN
A:
[16-391]
-------------
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
-----
Y
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
---------
Q
Y
-----
P
I
S
-
L
V
L
A
P
T
R
E
L
A
---
V
Q
I
Y
E
E
-
A
R
K
F
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
G
C
----
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
G
---
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
-----
E
Q
D
TMP-
P
----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
-----
T
S
E
N
I
T
Q
K
V
V
W
--
V
E
E
---
S
---
D
---
K
R
S
F
L
L
D
L
L
N
A
----------
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
-
N
E
R
N
-
I
N
I
T
K
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
85.38
35%
-104
- C3 -
4PXA
5
DDX3X_HUMAN
A:
[66-441]
-------------
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
-----
Y
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
---------
Q
Y
-----
P
I
S
-
L
V
L
A
P
T
R
E
L
A
---
V
Q
I
Y
E
E
-
A
R
K
F
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
G
C
----
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
G
---
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
V
M
-
G
-
F
E
P
Q
I
R
R
I
V
-----
E
Q
D
TMP-
P
----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
V
G
-
S
T
S
E
N
I
T
Q
K
V
V
W
--
V
E
E
---
S
---
D
---
K
R
S
F
L
L
D
L
L
N
A
----------
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
-
N
E
R
N
-
I
N
I
T
K
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
85.14
38%
-135
- C3 -
2VSO
1
IF4A_YEAST
B:
[24-377]
--------------
F
D
D
-
M
E
L
D
E
N
L
L
R
G
V
-
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
-
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
---
R
I
-----
D
T
S
------------------
V
---------
K
A
-----
P
Q
A
-
L
M
L
A
P
T
R
E
L
A
---
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
D
-
I
K
V
H
A
C
I
G
----------
L
-
R
--
D
A
----
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
R
R
---
R
-
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
-----
T
L
L
----
P
----
P
-
T
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
-
L
T
L
E
G
I
K
Q
F
--
Y
--
V
N
V
---
E
---
E
EEY
K
Y
E
C
L
T
D
L
Y
D
S
----------
I
-
S
V
T
Q
A
-
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
-
T
N
E
D
-
V
G
A
M
R
E
L
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
85.13
34%
-111
- C3 -
3G0H
4
DD19B_HUMAN
A:
[35-406]
------
S
P
L
Y
S
V
K
S
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
-----
E
P
A
------------------
N
---------
K
Y
-----
P
Q
C
-
L
C
L
S
P
T
Y
E
L
A
---
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
E
L
K
L
-------
A
Y
A
V
R
G
N
K
L
-
E
-
R
G
Q
KISE
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
K
L
---
K
F
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
-----
R
M
L
----
P
----
R
-
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
-
E
T
L
D
T
I
K
Q
Y
--
Y
--
V
L
C
---
S
S
R
D
E
---
K
F
Q
A
L
C
N
L
Y
G
A
----------
I
-
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
-
M
N
I
L
N
R
I
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
85.10
38%
-134
- C3 -
2VSO
1
IF4A_YEAST
A:
[24-377]
--------------
F
D
D
-
M
E
L
D
E
N
L
L
R
G
V
-
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
-
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
---
R
I
-----
D
T
S
------------------
V
---------
K
A
-----
P
Q
A
-
L
M
L
A
P
T
R
E
L
A
---
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
D
-
I
K
V
H
A
C
I
G
----------
L
-
R
--
D
A
----
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
R
R
---
R
-
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
-----
T
L
L
----
P
----
P
-
T
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
-
L
T
L
E
G
I
K
Q
F
--
Y
--
V
N
V
---
E
---
E
EEY
K
Y
E
C
L
T
D
L
Y
D
S
----------
I
-
S
V
T
Q
A
-
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
-
T
N
E
D
-
V
G
A
M
R
E
L
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
84.84
37%
-103
- C3 -
2DB3
3
VASA1_DROME
A:
[53-408]
---------
Q
P
I
Q
H
F
T
S
-
A
D
L
R
D
I
I
I
D
N
V
-
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
K
L
-----
L
E
D
------------------
P
H
E
L
E
L
----
G
R
-----
P
Q
V
-
V
I
V
S
P
T
R
E
L
A
---
I
Q
I
F
N
E
A
R
K
F
A
F
E
S
-
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
-
T
-
R
G
C
----
H
V
V
I
A
T
P
G
R
L
L
D
F
V
-
D
R
T
---
F
-
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
S
E
D
M
R
R
I
M
-----
T
H
V
----
T
MR--
P
-
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
-
G
A
C
S
D
V
K
Q
T
--
I
--
Y
E
V
---
N
KY-
A
---
K
R
S
K
L
I
E
I
L
S
E
------------
Q
A
D
G
T
-
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
-
D
P
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
84.84
34%
-115
- C3 -
3FHT
4
DD19B_HUMAN
A:
[19-390]
------
S
P
L
Y
S
V
K
S
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
-----
E
P
A
------------------
N
---------
K
Y
-----
P
Q
C
-
L
C
L
S
P
T
Y
E
L
A
---
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
E
L
K
L
-------
A
Y
A
V
R
G
N
K
L
-
E
-
R
G
Q
KISE
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
K
L
---
K
F
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
-----
R
M
L
----
P
----
R
-
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
-
E
T
L
D
T
I
K
Q
Y
--
Y
--
V
L
C
---
S
S
R
D
E
---
K
F
Q
A
L
C
N
L
Y
G
A
----------
I
-
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
-
M
N
I
L
N
R
I
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
84.83
35%
-103
- C3 -
5E7J
1
DDX3X_HUMAN
A:
[49-424]
-------------
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
-----
Y
S
D
GPG
E
A
L
R
A
M
K--------
K
---------
Q
Y
-----
P
I
S
-
L
V
L
A
P
T
R
E
L
A
---
V
Q
I
Y
E
E
-
A
R
K
F
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
G
C
----
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
G
---
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
-----
E
Q
D
TMP-
P
----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
V
G
-
S
T
S
E
N
I
T
Q
K
V
V
W
--
V
E
E
---
S
---
D
---
K
R
S
F
L
L
D
L
L
N
A
----------
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
-
N
E
R
N
-
I
N
I
T
K
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
84.74
38%
-132
- C3 -
2VSX
1
IF4A_YEAST
B:
[24-377]
--------------
F
D
D
-
M
E
L
D
E
N
L
L
R
G
V
-
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
-
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
---
R
I
-----
D
T
S
------------------
V
---------
K
A
-----
P
Q
A
-
L
M
L
A
P
T
R
E
L
A
---
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
D
-
I
K
V
H
A
C
I
G
----------
L
-
R
--
D
A
----
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
R
R
---
R
-
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
-----
T
L
L
----
P
----
P
-
T
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
-
L
T
L
E
G
I
K
Q
F
--
Y
--
V
N
V
---
E
---
E
EEY
K
Y
E
C
L
T
D
L
Y
D
S
----------
I
-
S
V
T
Q
A
-
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
-
T
N
E
D
-
V
G
A
M
R
E
L
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
84.69
38%
-132
- C3 -
2VSX
1
IF4A_YEAST
A:
[24-377]
--------------
F
D
D
-
M
E
L
D
E
N
L
L
R
G
V
-
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
-
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
---
R
I
-----
D
T
S
------------------
V
---------
K
A
-----
P
Q
A
-
L
M
L
A
P
T
R
E
L
A
---
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
D
-
I
K
V
H
A
C
I
G
----------
L
-
R
--
D
A
----
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
R
R
---
R
-
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
-----
T
L
L
----
P
----
P
-
T
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
-
L
T
L
E
G
I
K
Q
F
--
Y
--
V
N
V
---
E
---
E
EEY
K
Y
E
C
L
T
D
L
Y
D
S
----------
I
-
S
V
T
Q
A
-
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
-
T
N
E
D
-
V
G
A
M
R
E
L
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
84.30
33%
-110
- C3 -
3FHT
4
DD19B_HUMAN
A:
[19-399]
------
S
P
L
Y
S
V
K
S
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
-----
E
P
A
------------------
N
---------
K
Y
-----
P
Q
C
-
L
C
L
S
P
T
Y
E
L
A
---
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
E
L
K
L
A
Y
A
V
R
G
N
K
---
L
E
R
G
Q
-
K
-
I
S
E
----
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
K
L
K--
F
-
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
-
A
T
Q
G
-
H
Q
D
Q
S
I
R
I
Q
-----
R
M
L
----
P
----
R
-
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
-
E
T
L
D
T
I
K
Q
Y
--
Y
--
V
L
C
---
S
S
R
D
E
---
K
F
Q
A
L
C
N
L
Y
G
A
----------
I
-
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
DKDGNP
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
-
D
S
K
H
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
84.02
35%
-125
- C3 -
1XTI
4
DX39B_HUMAN
A:
[9-358]
-------------
G
F
R
D
-
F
L
L
K
P
E
L
L
R
A
I
-
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
--
M
-
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
---
Q
L
-----
E
P
V
------------------
T
---------
G
Q
-----
V
S
V
-
L
V
M
C
H
T
R
E
L
A
---
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
M
P
N
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
K
N
C
P
----
H
I
V
V
G
T
P
G
R
I
L
A
L
A
-
R
N
K
---
S
-
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q
L
D
-
M
R
R
D
V
Q
E
I
F
-----
R
M
T
----
P
----
H
-
E
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
D
D
E
T
K
L
T
L
H
G
L
Q
Q
Y
--
Y
--
V
K
L
---
K
DN-
E
---
K
N
R
K
L
F
D
L
L
D
V
----------
L
-
E
F
N
Q
V
-
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
------
E
------
D
S
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
-
S
D
E
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
83.71
34%
-112
- C3 -
3FHT
6
DD19B_HUMAN
B:
[19-390]
------
S
P
L
Y
S
V
K
S
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
-----
E
P
A
------------------
N
---------
K
Y
-----
P
Q
C
-
L
C
L
S
P
T
Y
E
L
A
---
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
E
L
K
L
-------
A
Y
A
V
R
G
N
--------KISE
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
K
L
---
K
F
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
-----
R
M
L
----
P
----
R
-
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
-
E
T
L
D
T
I
K
Q
Y
--
Y
--
V
L
C
---
S
S
R
D
E
---
K
F
Q
A
L
C
N
L
Y
G
A
----------
I
-
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
-
M
N
I
L
N
R
I
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
83.48
35%
-101
- C3 -
5E7M
1
DDX3X_HUMAN
A:
[49-424]
-------------
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
-----
Y
S
D
GPG
E
A
L
R
A
M
KR
R
------
K
---------
Q
Y
-----
P
I
S
-
L
V
L
A
P
T
R
E
L
A
---
V
Q
I
Y
E
E
-
A
R
K
F
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
G
C
----
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
G
---
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
-----
E
Q
D
TMP-
P
----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
V
G
-
S
T
S
E
N
I
T
Q
K
V
V
W
--
V
E
E
---
S
---
D
---
K
R
S
F
L
L
D
L
L
N
A
----------
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
-
N
E
R
N
-
I
N
I
T
K
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
82.59
33%
-115
- C3 -
4BRW
2
DHH1_YEAST
A:
[2-355]
-------------
T
F
E
D
-
F
Y
L
K
R
E
L
L
M
G
I
-
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
---
K
V
-----
K
P
K
------------------
L
---------
N
K
-----
I
Q
A
-
L
I
M
V
P
T
R
E
L
A
---
L
Q
T
S
Q
V
V
R
T
L
G
K
H
C
G
-
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
-
E
T
V
----
H
I
L
V
G
T
P
G
R
V
L
D
L
A
-
S
R
K
---
V
-
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
-
S
R
-
D
-
F
K
T
I
I
E
Q
I
L
-----
S
F
L
----
P
----
P
-
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
M
E
E
L
-
T
L
-
K
G
I
T
Q
Y
--
Y
A
F
V
E
E
---
R
---
Q
---
K
L
H
C
L
N
T
L
F
S
K
----------
L
-
Q
I
N
Q
A
-
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
-
N
W
N
D
-
R
F
N
L
Y
K
I
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
81.42
34%
-109
- C3 -
3RRN
2
DBP5_YEAST
A:
[1-367]
--------
G
A
M
A
K
S
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
-----
N
P
E
------------------
D
---------
A
S
-----
P
Q
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
---------
Q
-
I
N
A
----
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
R
K
---
L
-
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
-
G
-
L
G
D
Q
C
I
R
V
K
-----
R
F
L
----
P
----
K
-
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
-------
D
A
I
K
Q
L
--
Y
--
M
D
C
KNE
A
---
D
---
K
F
D
V
L
T
E
L
Y
G
V
----------
M
-
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
-
H
D
K
N
S
F
N
I
L
S
A
I
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
80.12
35%
-113
- C3 -
3PEY
11
DBP5_YEAST
A:
[4-359]
-----------
A
K
S
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
-----
N
P
E
------------------
D
---------
A
S
-----
P
Q
A
-
I
C
L
A
P
S
R
E
L
A
---
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
-
K
I
T
S
Q
L
I
V
P
D
S
F
E
----
K
N
K
-
Q
-
I
N
A
----
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
R
K
---
L
-
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
-----
R
F
L
----
P
----
K
-
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
E
-
V
N
V
D
A
I
K
Q
L
--
Y
--
M
D
C
---
K
N
E
A
D
---
K
F
D
V
L
T
E
L
Y
G
L
----------
M
-
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
-
H
D
K
N
-
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
79.81
33%
-117
- C3 -
3PEY
11
DBP5_YEAST
A:
[4-367]
-----------
A
K
S
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
-----
N
P
E
------------------
D
---------
A
S
-----
P
Q
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
I
T
S
Q
L
-
I
V
P
D
S
F
E
K
N
K
Q
I
---------
N
A
----
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
R
K
---
L
-
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
-
G
-
L
G
D
Q
C
I
R
V
K
-----
R
F
L
----
P
----
K
-
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
E
-
V
N
V
D
A
I
K
Q
L
--
Y
--
M
D
C
KN
E
A
---
D
---
K
F
D
V
L
T
E
L
Y
G
L
----------
M
-
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
-
H
D
K
N
S
F
N
I
L
S
A
I
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
79.32
34%
-111
- C3 -
3PEW
9
DBP5_YEAST
A:
[4-367]
-----------
A
K
S
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
-----
N
P
E
------------------
D
---------
A
S
-----
P
Q
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
---------
Q
-
I
N
A
----
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
R
K
---
L
-
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
-
G
-
L
G
D
Q
C
I
R
V
K
-----
R
F
L
----
P
----
K
-
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
E
-
V
N
V
D
A
I
K
Q
L
--
Y
--
M
D
C
KNE
A
---
D
---
K
F
D
V
L
T
E
L
Y
G
V
----------
M
-
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
-
H
D
K
N
S
F
N
I
L
S
A
I
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
78.72
33%
-112
- C3 -
5ELX
7
?
A:
[1-364]
-----------
A
K
S
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
-----
N
P
E
------------------
D
---------
A
S
-----
P
Q
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
---------
Q
-
I
N
A
----
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
R
K
---
L
-
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
-
G
-
L
G
D
Q
C
I
R
V
K
-----
R
F
L
----
P
----
K
-
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
E
-
V
N
V
D
A
I
K
Q
L
--
Y
--
M
D
C
KN
E
A
---
D
---
K
F
D
V
L
T
E
L
Y
G
L
----------
M
-
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
-
H
D
K
N
S
F
N
I
L
S
A
I
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
76.86
34%
-115
- C3 -
3RRM
1
DBP5_YEAST
A:
[11-367]
-------------------
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
-----
N
P
E
------------------
D
---------
A
S
-----
P
Q
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
---------
Q
-
I
N
A
----
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
R
K
---
L
-
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
-
G
-
L
G
D
Q
C
I
R
V
K
-----
R
F
L
----
P
----
K
-
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
-----
V
N
V
D
A
I
K
Q
L
--
Y
--
M
D
C
KN
E
A
---
D
---
K
F
D
V
L
T
E
L
Y
G
V
----------
M
-
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
------
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
-
H
D
K
N
S
F
N
I
L
S
A
I
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
70.28
46%
-127
- C3 -
2GXS
3
?
A:
[3-205]
--------------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
------------------
Q
ERG------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
70.19
46%
-128
- C3 -
3NBF
4
?
C:
[3-205]
--------------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
------------------
Q
ERG------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
69.72
46%
-128
- C3 -
2GXQ
2
?
A:
[3-205]
--------------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
------------------
Q
ERG------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
69.65
46%
-129
- C3 -
2GXS
4
?
B:
[3-205]
--------------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
------------------
Q
ERG------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
69.42
46%
-124
- C3 -
3NBF
2
?
A:
[3-205]
--------------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
------------------
Q
ERG------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
69.17
46%
-133
- C3 -
3NBF
2
?
D:
[3-205]
--------------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
------------------
Q
ERG------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
69.16
46%
-124
- C3 -
3NBF
2
?
B:
[3-205]
--------------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
------------------
Q
ERG------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
68.84
46%
-130
- C3 -
3MWL
2
?
B:
[3-205]
--------------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
------------------
Q
ERG------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
68.65
46%
-128
- C3 -
3MWK
2
?
B:
[3-205]
--------------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
-----
A
P
S
------------------
Q
ERG------
R
K
-----
P
R
A
-
L
V
L
T
P
T
R
E
L
A
---
L
Q
V
A
S
E
L
T
---
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
G
A
----
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
Q
G
---
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
-----
S
A
T
----
P
----
P
-
S
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
66.22
35%
-120
- C3 -
3FMO
1
DD19B_HUMAN
B:
[86-298]
------
S
P
L
Y
S
V
K
S
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
-----
E
P
A
------------------
N
---------
K
Y
-----
P
Q
C
-
L
C
L
S
P
T
Y
E
L
A
---
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
E
L
K
L
-------
A
Y
A
V
R
G
N
K
L
-
E
-
R
G
Q
KISE
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
K
L
---
K
F
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
-----
R
M
L
----
P
----
R
-
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
66.02
35%
-114
- C3 -
4PX9
1
DDX3X_HUMAN
B:
[66-284]
-------------
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
-----
Y
S
D
GPGEALRAMKENGRYG
R
R
K
---------
Q
Y
-----
P
I
S
-
L
V
L
A
P
T
R
E
L
A
---
V
Q
I
Y
E
E
A
R
K
F
-
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
G
C
----
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
G
---
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
-----
E
Q
D
TMP-
P
----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
65.95
35%
-117
- C3 -
1T6N
1
DX39B_HUMAN
B:
[14-218]
------------
S
G
F
R
D
-
F
L
L
K
P
E
L
L
R
A
I
-
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
--
M
-
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
---
Q
L
-----
E
P
V
------------------
T
---------
G
Q
-----
V
S
V
-
L
V
M
C
H
T
R
E
L
A
---
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
M
P
N
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
-
K
N
C
P---
H
I
V
V
G
T
P
G
R
I
L
A
L
A
-
R
N
K
---
S
-
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
-
D
-
M
R
R
D
V
Q
E
I
F
-----
R
M
T
----
P
----
H
-
E
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
65.83
35%
-115
- C3 -
4PX9
1
DDX3X_HUMAN
C:
[66-284]
-------------
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
-----
Y
S
D
GPGEALRAMKENGRYGRR
K
---------
Q
Y
-----
P
I
S
-
L
V
L
A
P
T
R
E
L
A
---
V
Q
I
Y
E
E
A
R
K
F
-
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
G
C
----
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
G
---
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
-----
E
Q
D
TMP-
P
----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
65.52
35%
-115
- C3 -
4PX9
1
DDX3X_HUMAN
A:
[66-284]
-------------
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
-----
Y
S
D
GPGEALRAMKENGRYG
R
R
K
---------
Q
Y
-----
P
I
S
-
L
V
L
A
P
T
R
E
L
A
---
V
Q
I
Y
E
E
A
R
K
F
-
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
G
C
----
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
R
G
---
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
-----
E
Q
D
TMP-
P
----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
65.42
36%
-128
- C3 -
3IUY
2
DDX53_HUMAN
A:
[21-226]
--------------
F
K
D
A
F
Q
Q
Y
P
D
L
L
K
S
I
-
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
Q
G
--
I
-
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
---
H
L
-----
D
------------------------------
N
G
-----
P
G
M
-
L
V
L
T
P
T
R
E
L
A
---
L
H
V
E
A
E
C
S
K
Y
S
--
Y
K
G
L
K
S
I
C
I
Y
G
------
Q
I
E
D
I
-
S
-
K
G
V
----
D
I
I
I
A
T
P
G
R
L
N
D
L
Q
-
M
N
N
---
S
-
V
N
L
R
S
I
T
Y
L
V
I
D
E
A
D
K
M
L
-
D
M
-
E
-
F
E
P
Q
I
R
K
I
L
-----
L
D
V
----
R
----
P
-
D
R
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
M
I
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
65.22
37%
-118
- C3 -
3FE2
3
DDX5_HUMAN
A:
[30-236]
-------------
N
F
Y
E
-
A
N
F
P
A
N
V
M
D
V
I
-
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
G
--
L
-
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
---
H
I
-----
N
H
Q
------------------
P
---------
F
L
ERGDG
P
I
C
-
L
V
L
A
P
T
R
E
L
A
---
Q
Q
V
Q
Q
V
A
A
E
Y
-
C
R
A
C
R
L
K
S
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
L
-
E
-
R
G
V
----
E
I
C
I
A
T
P
G
R
L
I
D
F
L
-
E
C
G
---
K
-
T
N
L
R
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
K
I
V
-----
D
Q
I
----
R
----
P
-
D
R
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
H
I
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
64.96
35%
-116
- C3 -
1T6N
1
DX39B_HUMAN
A:
[14-218]
------------
S
G
F
R
D
-
F
L
L
K
P
E
L
L
R
A
I
-
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
--
M
-
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
---
Q
L
-----
E
P
V
------------------
T
---------
G
Q
-----
V
S
V
-
L
V
M
C
H
T
R
E
L
A
---
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
M
P
N
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
-
K
N
C
P---
H
I
V
V
G
T
P
G
R
I
L
A
L
A
-
R
N
K
---
S
-
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
-
D
-
M
R
R
D
V
Q
E
I
F
-----
R
M
T
----
P
----
H
-
E
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
64.81
37%
-116
- C3 -
3FE2
4
DDX5_HUMAN
B:
[30-236]
-------------
N
F
Y
E
-
A
N
F
P
A
N
V
M
D
V
I
-
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
G
--
L
-
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
---
H
I
-----
N
H
Q
------------------
P
---------
F
L
ERGDG
P
I
C
-
L
V
L
A
P
T
R
E
L
A
---
Q
Q
V
Q
Q
V
A
A
E
Y
-
C
R
A
C
R
L
K
S
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
L
-
E
-
R
G
V
----
E
I
C
I
A
T
P
G
R
L
I
D
F
L
-
E
C
G
---
K
-
T
N
L
R
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
K
I
V
-----
D
Q
I
----
R
----
P
-
D
R
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
H
I
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
64.53
34%
-119
- C3 -
1VEC
1
DDX6_HUMAN
B:
[5-206]
--------------
F
E
D
-
Y
C
L
K
R
E
L
L
M
G
I
-
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
---
R
L
-----
D
L
K
------------------
K
---------
D
N
-----
I
Q
A
-
M
V
I
V
P
T
R
E
L
A
---
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
-
D
-
D
T
V
----
H
V
V
I
A
T
P
G
R
I
L
D
L
I
-
K
K
G
---
V
-
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
-----
L
T
L
----
P
----
K
-
N
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
E
K
P
Y
E
I
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
64.01
36%
-126
- C3 -
3IUY
2
DDX53_HUMAN
B:
[21-226]
--------------
F
K
D
A
F
Q
Q
Y
P
D
L
L
K
S
I
-
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
Q
G
--
I
-
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
---
H
L
-----
D
S
-----------------------------
N
G
-----
P
G
M
-
L
V
L
T
P
T
R
E
L
A
---
L
H
V
E
A
E
C
S
K
Y
S
--
Y
K
G
L
K
S
I
C
I
Y
G
----------------
V
----
D
I
I
I
A
T
P
G
R
L
N
D
L
Q
-
M
N
N
---
S
-
V
N
L
R
S
I
T
Y
L
V
I
D
E
A
D
K
M
L
-
D
M
-
E
-
F
E
P
Q
I
R
K
I
L
-----
L
D
V
----
R
----
P
-
D
R
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
M
I
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
63.83
40%
-117
- C3 -
3BER
4
DDX47_HUMAN
A:
[44-245]
-------------
T
F
K
D
-
L
G
V
T
D
V
L
C
E
A
C
-
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
Q
G
--
R
-
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
N
---
A
L
-----
L
E
T
------------------
P
---------
Q
R
-----
L
F
A
-
L
V
L
T
P
T
R
E
L
A
---
F
Q
I
S
E
Q
F
E
A
L
G
S
S
I
G
V
Q
S
A
V
-
I
V
G
G
I
D
S
M
S
Q
S
L
A
L
-
A
-
K
K
P
----
H
I
I
I
A
T
P
G
R
L
I
D
H
L
-
E
N
T
---
K
G
F
N
L
R
A
L
K
Y
L
V
M
D
E
A
D
R
I
L
-
N
M
-
D
-
F
E
T
E
V
D
K
I
L
-----
K
V
I
----
P
----
R
-
D
R
K
T
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
N
P
--
V
K
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
62.07
31%
-113
- C3 -
2OXC
1
DDX20_HUMAN
A:
[24-223]
------------
A
D
F
E
S
-
L
L
L
S
R
P
V
L
E
G
L
-
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
G
--
L
-
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
---
S
L
-----
V
L
E
------------------
N
---------
L
S
-----
T
Q
I
-
L
I
L
A
P
T
R
E
I
A
---
V
Q
I
H
S
V
I
T
A
I
G
I
K
M
E
G
L
E
C
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
L
-
K
-
K
-
C
----
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
-
E
L
D
---
Y
-
L
N
P
G
S
I
R
L
F
I
L
D
E
A
D
K
L
L
-
E
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
-----
S
S
L
----
P
----
A
-
S
K
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
61.34
31%
-116
- C3 -
2OXC
1
DDX20_HUMAN
B:
[24-223]
------------
A
D
F
E
S
-
L
L
L
S
R
P
V
L
E
G
L
-
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
G
--
L
-
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
---
S
L
-----
V
L
E
------------------
N
---------
L
S
-----
T
Q
I
-
L
I
L
A
P
T
R
E
I
A
---
V
Q
I
H
S
V
I
T
A
I
G
I
K
M
E
G
L
E
C
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
L
-
K
-
K
-
C
----
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
-
E
L
D
---
Y
-
L
N
P
G
S
I
R
L
F
I
L
D
E
A
D
K
L
L
-
E
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
-----
S
S
L
----
P
----
A
-
S
K
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
60.34
33%
-111
- C3 -
2PL3
6
DDX10_HUMAN
A:
[27-234]
--------------
F
S
D
-
F
P
L
S
K
K
T
L
K
G
L
-
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
Q
G
--
K
-
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
L
Y
R
L
-----
Q
W
T
------------------
S
---------
T
D
-----
G
L
G
V
L
I
I
S
P
T
R
E
L
A
---
Y
Q
T
F
E
V
L
R
K
V
G
K
N
-
H
D
F
S
A
G
L
I
I
G
G
--
L
K
H
E
-
A
E
R
-
I
-
N
N
I
----
N
I
L
V
C
T
P
G
R
L
L
Q
H
M
D
E
T
V
---
S
-
F
H
A
T
D
L
Q
M
L
V
L
D
E
A
D
R
I
L
-
D
M
-
G
-
F
A
D
T
M
N
A
V
I
-----
E
N
L
----
P
----
K
-
K
R
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
E
Y
V
W
V
H
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
27.43
35%
-28
- C3 -
4DB2
3
MS116_YEAST
B:
[68-154]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
26.51
35%
-27
- C3 -
4DB2
4
MS116_YEAST
C:
[68-154]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
20.91
35%
-15
- C3 -
4DB2
2
D:
[68-154]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
---------
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
N
Y
I
H
R
I
G
----------
S
V
L
F
I
-
C
K
D
E
-
L
P
F
V
R
E
L
E
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------