@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1263: (2016-04-30 )
MDPTDLAFAGAAAQARMLADGALTAPMLLEVYLQRIERLDSHLRAYRVVQFDRARAEAEAAQQRLDAGERLPLLGVPIAIKDDVDIAGEVTTYGSAGHGPAATSDAEVVRRLRAAGAVIIGKTNVPELMIMPFTESLAFGATRNPWCLNRTPGGSSGGSAAAVAAGLAPVALGSDGGGSIRIPCTWCGLFGLKPQRDRISLEPHDGAWQGLSVNGPIARSVMDAALLLDATTTVPGPEGEFVAAAARQPGRLRIALSTRVPTPLPVRCGKQELAAVHQAGALLRDLGHDVVVRDPDYPASTYANYLPRFFRGISDDADAQAHPDRLEARTRAIARLGSFFSDRRMAALRAAEVVLSSRIQSIFDDVDVVVTPGAATGPSRIGAYQRRGAVSTLLLVVQRVPYFQVWNLTGQPAAVVPWDFDGDGLPMSVQLVGRPYDEATLLALAAQIESARPWAHRRPSVS
Atome Classification :
(53 SA)
.........10........20........30........40........50........60...-.....70--...-.....80.....-.-..90...-...---..--100......--------..110.......120.......130.......140.......150.......160.......170.......180.......190.......200.---......---210---.........220.......----------230------.......-------.--------.240---.......250....-...260--.--.---.......270......---.280.....-----.-.290.....----..300-------------.........------310......----------------------.------------------320------------------------.-----------.-------....--..330-----....---...-----.-----340.....-------------..350.--......360..-.....370------------.......380...---------...---------.390.........400.......410.....--..420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDPT
D
L
AFAG
A
A
A
Q
A
R
M
LADGAL
T
A
P
M
L
L
E
V
Y
L
Q
R
I
E
R
L
D
S
H
L
R
A
Y
R
V
V
Q
F
D
RAR
A
E
A
E
A
A
Q
Q
R
-LDAGERL--PLL-GV
P
I
A
I
KDDVDI-A-GEVTTYG-SAG---HG--PA-AT
S
D
A
E
--------
V
V
R
R
L
R
AA
G
A
V
I
I
GKTNV
P
E
L
M
I
M
PFT
E
S
LAFGATRNPWCLNRTPGGSSGG
S
A
A
A
V
AAGL
A
P
V
A
LGSDGG
G
S
I
R
I
P
C
T
W
C
GLFGLKPQR
D
R
I
SLEP---HDGAWQ---G-----LSVN
G
P
I
A
R
S
V
M
D
A
A
L
L
L
D----------A--------TTTVPGP-------E--------G
E
F
V
---
A
AAARQP
G
R
L
R
I
A
L-STRV----P--T---PLPVRC
G
K
Q
E
L
A
A
V
H
Q
---
A
G
A
L
L
R
DLG-----H-
D
V
V
V
RDPDY----
P
A
S
---------------
T
Y
A
N
Y
L
P
R
F
------
F
RGISDDAD----------------------A------------------QA-------------------------H-----------
P
-------
D
R
L
E
--
A
R
T
R
------
A
I
A
R
---
L
G
S
-----
F
-----
F
S
D
R
R
M
A
A
-------------
L
R
A
A
E
V
--
V
L
S
S
R
I
Q
S
I
FD-DV
D
V
V
VTP------------GAATG
P
S
R
I
G
A
Y
Q
---------RR
G
---------
A
V
--
S
T
L
L
L
V
V
QRVPY
F
Q
V
WNLTGQ
P
A
A
V
V
P--WDFDGDGL
P
M
S
V
Q
L
VGRPY
D
E
A
T
L
L
A
L
A
A
Q
I
ESARPWAHRRPSVS
5
PsiBlast_PDB
95.10
34%
-66
- C6 -
4WJ3
-
GATA_PSEAE
A:
[11-482]
--------------
A
R
A
L
A
D
K
Q
F
S
A
E
E
L
T
R
T
L
L
G
R
I
R
Q
L
D
P
Q
L
N
S
F
I
S
I
T
D
D
L
A
I
A
Q
A
K
A
A
D
E
R
-
R
A
N
G
E
N
G
--
A
L
L
-
G
A
P
I
A
H
K
D
L
F
C
T
-
Q
-
G
V
R
T
S
C
G
-
S
K
M
L--
D
N
--
F
V
-
S
P
Y
D
A
T
--------
V
V
E
K
L
T
A
A
G
A
V
T
L
G
K
L
N
M
D
E
F
A
M
G
S
S
N
Q
S
S
H
Y
G
A
V
K
N
P
W
S
L
D
R
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
R
L
L
P
A
A
T
G
T
D
T
G
G
S
I
R
Q
P
A
A
L
T
N
L
T
G
I
K
P
T
Y
G
R
V
S
R
W
G
---
M
I
A
Y
A
S
---
S
-----
L
D
Q
G
G
P
L
A
R
T
A
E
D
C
A
L
M
L
G
----------
V
M
A
G
F
D
PKD
S
T
S
V
E
Q
P
-------
V
--------
D
D
Y
L
---
A
A
L
Q
K
P
L
S
G
L
R
I
G
L
P
R
E
Y
F
----
G
--
A
---
G
L
D
S
R
I
A
D
A
V
L
A
V
V
E
E
L
K
T
L
G
A
T
V
K
D
I
S
L
PNMQ
H
-
A
I
P
A
Y
Y
V
I
A
----
P
A
E
---------------
A
S
S
N
-
L
S
R
F
DGVRYG
Y
R
-----
C
D
----------------------
A
------------------
P
Q
-------------------------
N
-----------
L
-------
E
D
L
Y
--
K
R
S
R
------
A
E
G
----
F
G
S
-----
E
-----
V
K
N
R
I
M
V
G
T
Y
A
L
SAGYYDAY
Y
L
Q
A
Q
K
I
R
R
L
I
K
N
D
F
V
S
A
F
A
-
E
V
D
V
I
L
G
P
------------
T
T
P
N
P
A
W
K
I
G
E
-
K
---------
N
D
D
---------
P
V
--
S
Q
Y
L
E
D
I
----
Y
T
I
T
A
N
L
A
G
L
P
G
L
S
M
P
--
A
G
F
-
V
D
G
L
P
V
G
V
Q
L
L
A
P
Y
F
Q
E
G
R
L
L
N
V
A
H
Q
Y
Q
Q
V
S
D
W
H
T
R
T
P
A
--
115
HHSearch
94.71
34%
-60
- C6 -
3A2Q
3
NYLA_FLASK
A:
[4-483]
----
V
D
L
W
Q
D
A
T
A
Q
A
E
L
V
R
S
G
E
I
S
R
T
E
L
L
E
A
T
I
A
H
V
Q
A
V
N
P
E
I
N
A
V
I
I
P
L
F
E
K
A
R
R
E
S
E
---------
L
A
S
G
--
P
F
A
-
G
V
P
Y
L
L
K
D
L
T
V
V
S
Q
-
G
D
I
N
T
S
S
-
I
K
G
---
M
K
E
S
G
Y
R
A
D
H
D
A
Y
--------
F
V
Q
R
M
R
A
A
G
F
V
L
L
G
K
T
N
T
P
E
M
G
N
Q
V
T
T
E
P
E
A
W
G
A
T
R
N
P
W
N
L
G
R
S
V
G
G
S
S
G
G
S
G
A
A
V
A
A
A
L
S
P
V
A
H
G
N
D
A
A
G
A
V
R
I
P
A
S
V
C
G
V
V
G
L
K
P
T
R
G
R
I
S
P
G
P
---
L
V
T
D
S
D
N
V
A
G
-----
A
A
H
E
G
L
F
A
R
S
V
R
D
I
A
A
L
L
D
----------
V
--------
V
S
G
H
R
P
G
-------
D
TFCAPTAS
R
P
Y
A
---
Q
G
I
S
E
N
P
G
S
L
R
V
G
V
-
L
T
H
N
----
P
VG
D
---
F
--
A
-
L
D
P
E
C
A
A
A
A
R
G
---
A
A
A
A
L
A
A
L
G
-----
H
-
D
V
N
D
A
Y
P
E
A
L
---
G
D
R
------------------
S
F
L
K
D
Y
------
S
T
I
C
D
V
A
I
A
----------------------
R
------------------
E
I
-------------------------
E
R
N
G
E
L
I
G
R
P
L
T
E
-------
D
D
V
E
--
W
T
S
W
------
E
M
V
K
---
R
A
D
-----
Q
-----
V
T
G
R
A
F
A
A
-------------
C
V
D
E
L
R
--
Y
Y
A
G
K
V
E
R
W
W
E
A
G
W
D
L
L
I
L
P
------------
T
V
T
R
Q
T
P
E
I
G
E
L
M
---------
L
A
K
GTDLEGRQS
A
F
--
I
S
--
G
S
L
Q
M
L
A
F
T
V
P
F
N
V
S
G
Q
P
A
I
S
L
P
--
I
G
M
S
S
D
G
M
P
I
G
V
Q
I
V
A
A
Y
G
R
E
D
L
L
L
Q
V
A
A
Q
L
E
G
A
L
P
W
V
A
R
R
P
Q
L
-
6
PsiBlast_PDB
93.06
32%
-59
- C6 -
3A2Q
3
NYLA_FLASK
A:
[4-483]
---
V
D
L
-
W
Q
D
A
T
A
Q
A
E
L
V
R
S
G
E
I
S
R
T
E
L
L
E
A
T
I
A
H
V
Q
A
V
N
P
E
I
N
A
V
I
I
P
L
F
E
K
A
R
R
E
S
E
L
A
S
G
-----------
P
F
A
-
G
V
P
Y
L
L
K
D
L
T
V
V
-
S
Q
G
D
I
N
T
S
S
-
I
K
G
M
K
E
S
G
--
Y
R
-
A
D
H
D
A
Y
--------
F
V
Q
R
M
R
A
A
G
F
V
L
L
G
K
T
N
T
P
E
M
G
N
Q
V
T
T
E
P
E
A
W
G
A
T
R
N
P
W
N
L
G
R
S
V
G
G
S
S
G
G
S
G
A
A
V
A
A
A
L
S
P
V
A
H
G
N
D
A
A
G
A
V
R
I
P
A
S
V
C
G
V
V
G
L
K
P
T
R
G
R
I
S
P
G
P
LVT
D
S
D
N
V
A
---
G
-----
A
A
H
E
G
L
F
A
R
S
V
R
D
I
A
A
L
L
D
----------
V
V
S
G
H
R
PGD
T
F
C
A
P
T
A
-------
S
--------
R
P
Y
A
---
Q
G
I
S
E
N
P
G
S
L
R
V
G
V
-
L
T
H
N
----
P
--
V
GDF
A
L
D
P
E
C
A
A
A
A
R
G
A
A
A
A
---
L
A
A
L
G
---------
H
-
D
V
---
N
D
A
Y
----
P
E
A
---------------
L
G
D
R
S
F
L
K
D
------
Y
S
T
I
C
D
V
A
I
----------------------
A
------------------
R
E
I
E
R
N
G
E
L
I
G
R
P
L
-------------
T
-----------
E
-------
D
D
V
E
--
W
T
S
W
------
E
M
V
K
---
R
A
D
-----
Q
-----
V
T
G
R
A
F
A
A
-------------
C
V
D
E
L
R
--
Y
Y
A
G
K
V
E
R
W
W
E
A
G
W
D
L
L
I
L
P
------------
T
V
T
R
Q
T
P
E
I
G
E
L
M
LAKGTDLEG
R
Q
S
---------
A
F
IS
G
S
L
Q
M
L
A
F
T
V
P
F
----
N
V
S
G
Q
P
A
I
S
L
P
--
I
G
M
S
S
D
G
M
P
I
G
V
Q
I
V
A
A
Y
G
R
E
D
L
L
L
Q
V
A
A
Q
L
E
G
A
L
P
W
V
A
R
R
P
Q
L
-
12
PsiBlast_PDB
92.69
28%
-70
- C6 -
2F2A
1
GATA_STAAM
A:
[33-474]
-----------------------------------
I
E
E
T
D
P
T
I
K
S
F
L
A
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
--
L
Q
A
K
D
Q
M
DG
K
L
F
-
G
I
P
M
G
I
K
D
N
I
I
T
-
N
-
G
L
E
T
T
C
A
-
S
K
M
L--
E
G
--
F
V
-
P
I
Y
E
S
T
--------
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
M
G
G
S
T
E
T
S
Y
F
K
K
T
V
N
P
F
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
----------
A
I
S
G
A
D
VND
S
T
S
A
P
V
D
-------
D
--------
V
D
F
T
---
S
E
I
G
K
D
I
K
G
L
K
V
A
L
-
P
K
E
Y
------------
L
G
E
G
V
A
D
D
V
K
E
A
V
Q
N
---
A
V
E
T
L
K
S
L
G
--------
A
V
V
E
E
V
S
L
----
P
N
T
---------------
K
F
G
--
I
P
S
Y
------
Y
V
I
A
S
S
E
A
S
----------------------
S
N
L
SRFDGIRYGYHSK---
E
A
-------------------------
H
-----------
S
L
E
E
L
Y
K
M
S
R
S
E
--
G
F
G
K
------
E
V
K
R
R
I
F
L
G
T
-----
F
A
L
SSG
Y
Y
D
A
Y
Y
K
K
-------------
S
Q
K
V
R
T
--
L
I
K
N
D
F
D
K
V
F
E
-
N
Y
D
V
V
V
G
P
------------
T
A
P
T
T
A
F
N
L
G
E
-----------------------
E
I
--
D
D
P
L
T
M
Y
A
N
D
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
--
C
G
-
Q
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
------------
11
PsiBlast_PDB
92.55
28%
-69
- C6 -
3IP4
-
GATA_STAAM
A:
[33-474]
-----------------------------------
I
E
E
T
D
P
T
I
K
S
F
L
A
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
--
L
Q
A
K
D
Q
M
DG
K
L
F
-
G
I
P
M
G
I
K
D
N
I
I
T
-
N
-
G
L
E
T
T
C
A
-
S
K
M
L--
E
G
--
F
V
-
P
I
Y
E
S
T
--------
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
M
G
G
S
T
E
T
S
Y
F
K
K
T
V
N
P
F
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
----------
A
I
S
G
A
D
VND
S
T
S
A
P
V
D
-------
D
--------
V
D
F
T
---
S
E
I
G
K
D
I
K
G
L
K
V
A
L
-
P
K
E
Y
------------
L
G
E
G
V
A
D
D
V
K
E
A
V
Q
N
---
A
V
E
T
L
K
S
L
G
--------
A
V
V
E
E
V
S
L
----
P
N
T
---------------
K
F
G
--
I
P
S
Y
------
Y
V
I
A
S
S
E
A
S
----------------------
S
N
L
SRFDGIRYGYHSK---
E
A
-------------------------
H
-----------
S
L
E
E
L
Y
K
M
S
R
S
E
--
G
F
G
K
------
E
V
K
R
R
I
F
L
G
T
-----
F
A
L
SSG
Y
Y
D
A
Y
Y
K
K
-------------
S
Q
K
V
R
T
--
L
I
K
N
D
F
D
K
V
F
E
-
N
Y
D
V
V
V
G
P
------------
T
A
P
T
T
A
F
N
L
G
E
-----------------------
E
I
--
D
D
P
L
T
M
Y
A
N
D
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
--
C
G
-
Q
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
------------
4
PsiBlast_PDB
92.31
32%
-59
- C6 -
3A2P
1
NYLA_FLASK
A:
[3-483]
--
K
V
D
L
-
W
Q
D
A
T
A
Q
A
E
L
V
R
S
G
E
I
S
R
T
E
L
L
E
A
T
I
A
H
V
Q
A
V
N
P
E
I
N
A
V
I
I
P
L
F
E
K
A
R
R
E
S
E
L
A
S
G
-----------
P
F
A
-
G
V
P
Y
L
L
K
D
L
T
V
V
-
S
Q
G
D
I
N
T
S
S
-
I
K
G
M
K
E
S
G
--
Y
R
-
A
D
H
D
A
Y
--------
F
V
Q
R
M
R
A
A
G
F
V
L
L
G
K
T
N
T
P
E
M
G
N
Q
V
T
T
E
P
E
A
W
G
A
T
R
N
P
W
N
L
G
R
S
V
G
G
S
S
G
G
S
G
A
A
V
A
A
A
L
S
P
V
A
H
G
N
D
A
A
G
S
V
R
I
P
A
S
V
C
G
V
V
G
L
K
P
T
R
G
R
I
S
P
G
P
LVT
D
S
D
N
V
A
---
G
-----
A
A
H
E
G
L
F
A
R
S
V
R
D
I
A
A
L
L
D
----------
V
VSGHRPGD
T
F
C
A
P
T
A
-------
S
--------
R
P
Y
A
---
Q
G
I
S
E
N
P
G
S
L
R
V
G
V
-
L
T
H
N
----
P
--
V
GDF
A
L
D
P
E
C
A
A
A
A
R
G
A
A
A
A
---
L
A
A
L
G
---------
H
-
D
V
---
N
D
A
Y
----
P
E
A
---------------
L
G
D
R
S
F
L
K
D
------
Y
S
T
I
C
D
V
A
I
----------------------
A
------------------
R
E
I
E
R
N
G
E
L
I
G
R
P
L
-------------
T
-----------
E
-------
D
D
V
E
--
W
T
S
W
------
E
M
V
K
---
R
A
D
-----
Q
-----
V
T
G
R
A
F
A
A
-------------
C
V
D
E
L
R
--
Y
Y
A
G
K
V
E
R
W
W
E
A
G
W
D
L
L
I
L
P
------------
T
V
T
R
Q
T
P
E
I
G
E
L
M
LAKGTDLEG
R
Q
S
---------
A
F
IS
G
S
L
Q
M
L
A
F
T
V
P
F
----
N
V
S
G
Q
P
A
I
S
L
P
--
I
G
M
S
S
D
G
M
P
I
G
V
Q
I
V
A
A
Y
G
R
E
D
L
L
L
Q
V
A
A
Q
L
E
G
A
L
P
W
V
A
R
R
P
Q
L
-
9
PsiBlast_PDB
91.93
28%
-70
- C6 -
2G5H
-
GATA_STAAM
A:
[33-474]
-----------------------------------
I
E
E
T
D
P
T
I
K
S
F
L
A
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
--
L
Q
A
K
D
Q
M
DG
K
L
F
-
G
I
P
M
G
I
K
D
N
I
I
T
-
N
-
G
L
E
T
T
C
A
-
S
K
M
L--
E
G
--
F
V
-
P
I
Y
E
S
T
--------
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
M
G
G
S
T
E
T
S
Y
F
K
K
T
V
N
P
F
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
----------
A
I
S
G
A
D
VND
S
T
S
A
P
V
D
-------
D
--------
V
D
F
T
---
S
E
I
G
K
D
I
K
G
L
K
V
A
L
-
P
K
E
Y
------------
L
G
E
G
V
A
D
D
V
K
E
A
V
Q
N
---
A
V
E
T
L
K
S
L
G
--------
A
V
V
E
E
V
S
L
----
P
N
T
---------------
K
F
G
--
I
P
S
Y
------
Y
V
I
A
S
S
E
A
S
----------------------
S
N
L
SRFDGIRYGYHSK---
E
A
-------------------------
H
-----------
S
L
E
E
L
Y
K
M
S
R
S
E
--
G
F
G
K
------
E
V
K
R
R
I
F
L
G
T
-----
F
A
L
SSG
Y
Y
D
A
Y
Y
K
K
-------------
S
Q
K
V
R
T
--
L
I
K
N
D
F
D
K
V
F
E
-
N
Y
D
V
V
V
G
P
------------
T
A
P
T
T
A
F
N
L
G
E
-----------------------
E
I
--
D
D
P
L
T
M
Y
A
N
D
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
--
C
G
-
Q
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
------------
110
HHSearch
91.71
27%
-63
- C6 -
3IP4
-
GATA_STAAM
A:
[2-485]
----
S
I
R
Y
E
S
V
E
N
L
L
T
L
I
K
D
K
K
I
K
P
S
D
V
V
K
D
I
Y
D
A
I
E
E
T
D
P
T
I
K
S
F
L
A
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
L
Q
A
K
D
Q
M
D
G
--
K
L
F
-
G
I
P
M
G
I
K
D
N
I
I
T
-
N
-
G
L
E
T
T
C
A
-
S
K
M
---
L
E
--
G
F
V
P
I
Y
E
S
T
--------
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
M
G
G
S
T
E
T
S
Y
F
K
K
T
V
N
P
F
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
----------
A
--------
I
S
G
A
D
V
N
-------
D
STSAPVDD
V
D
F
T
---
S
E
I
G
K
D
I
K
G
L
K
V
A
L
-
P
K
E
Y
----
L
--
G
---
E
--
G
-
V
A
D
D
V
K
E
A
V
Q
N
---
A
V
E
T
L
K
S
L
G
-----
A
-
V
V
E
E
V
S
L
P
N
----
T
K
F
---------------
G
I
P
----
S
Y
------
Y
V
I
A
S
S
E
A
S
----------------------
S
------------------
N
L
SRFDGIRYGYHSKEAHS
L
E
E
L
Y
K
M
S
R
-----------
S
-------
E
G
F
G
--
K
E
V
K
------
R
R
I
F
---
L
G
T
F
A
L
SS
G
-----
Y
Y
D
A
Y
Y
K
K
-------------
S
Q
K
V
R
T
--
L
I
K
N
D
F
D
K
V
F
E
-
N
Y
D
V
V
V
G
P
------------
T
A
P
T
T
A
F
N
L
G
E
E
I
---------
D
D
P
-------------
L
T
---
M
Y
A
N
D
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
--
C
G
Q
S
-
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
Q
Y
N
L
H
D
V
Y
E
K
L
-
8
PsiBlast_PDB
91.62
28%
-69
- C6 -
2DQN
1
GATA_STAAM
A:
[33-474]
-----------------------------------
I
E
E
T
D
P
T
I
K
S
F
L
A
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
--
L
Q
A
K
D
Q
M
D
G
K
L
F
-
G
I
P
M
G
I
K
D
N
I
I
T
-
N
-
G
L
E
T
T
C
A
-
S
K
M
L--
E
G
--
F
V
-
P
I
Y
E
S
T
--------
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
M
G
G
S
T
E
T
S
Y
F
K
K
T
V
N
P
F
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
----------
A
I
S
G
A
D
VND
S
T
S
A
P
V
D
-------
D
--------
V
D
F
T
---
S
E
I
G
K
D
I
K
G
L
K
V
A
L
-
P
K
E
Y
------------
L
G
E
G
V
A
D
D
V
K
E
A
V
Q
N
---
A
V
E
T
L
K
S
L
G
--------
A
V
V
E
E
V
S
L
----
P
N
T
---------------
K
F
G
--
I
P
S
Y
------
Y
V
I
A
S
S
E
A
S
----------------------
S
N
LSRFDGIRYGYHSK---
E
A
-------------------------
H
-----------
S
L
E
E
L
Y
K
M
S
R
S
E
--
G
F
G
K
------
E
V
K
R
R
I
F
L
G
T
-----
F
A
L
SSG
Y
Y
D
A
Y
Y
K
K
-------------
S
Q
K
V
R
T
--
L
I
K
N
D
F
D
K
V
F
E
-
N
Y
D
V
V
V
G
P
------------
T
A
P
T
T
A
F
N
L
G
E
-----------------------
E
I
--
D
D
P
L
T
M
Y
A
N
D
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
--
C
G
-
Q
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
------------
109
HHSearch
90.92
32%
-62
- C6 -
4WJ3
-
GATA_PSEAE
A:
[2-483]
-----
L
H
Q
L
T
L
A
E
I
A
R
A
L
A
D
K
Q
F
S
A
E
E
L
T
R
T
L
L
G
R
I
R
Q
L
D
P
Q
L
N
S
F
I
S
I
T
D
D
L
A
I
A
Q
A
K
A
A
D
E
R
R
A
N
G
-
E
N
G
--
A
L
L
-
G
A
P
I
A
H
K
D
L
F
C
T
-
Q
-
G
V
R
T
S
C
G
-
S
K
M
---
L
D
--
N
F
V
S
P
Y
D
A
T
--------
V
V
E
K
L
T
A
A
G
A
V
T
L
G
K
L
N
M
D
E
F
A
M
G
S
S
N
Q
S
S
H
Y
G
A
V
K
N
P
W
S
L
D
R
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
R
L
L
P
A
A
T
G
T
D
T
G
G
S
I
R
Q
P
A
A
L
T
N
L
T
G
I
K
P
T
Y
G
R
V
S
R
W
G
---
M
I
A
Y
A
S
---
S
-----
L
D
Q
G
G
P
L
A
R
T
A
E
D
C
A
L
M
L
G
----------
V
--------
M
A
G
F
D
P
K
DST
S
V
--
E
--------
Q
P
V
D
DYL
A
A
L
Q
K
P
L
S
G
L
R
I
G
L
-
P
R
E
Y
----
F
--
G
---
A
--
G
-
L
D
S
R
I
A
D
A
V
L
A
---
V
V
E
E
L
K
T
L
G
-----
A
-
T
V
K
D
I
S
L
P
N
----
M
Q
H
---------------
A
I
P
----
A
Y
------
Y
V
I
A
P
A
E
A
S
----------------------
S
N
L
S
RFDGVRYGYRCDAPQ
N
L
E
D
L
Y
K
R
S
------------------
R
-----------
A
-------
E
G
F
G
--
S
E
V
K
------
N
R
I
M
---
V
G
T
Y
A
L
SA
G
-----
Y
Y
D
A
Y
Y
L
Q
-------------
A
Q
K
I
R
R
--
L
I
K
N
D
F
V
S
A
F
A
-
E
V
D
V
I
L
G
P
------------
T
T
P
N
P
A
W
K
I
G
E
K
N
---------
D
D
P
-------------
V
S
---
Q
Y
L
E
D
I
Y
T
I
T
A
N
L
A
G
L
P
G
L
S
M
P
--
A
G
F
V
-
D
G
L
P
V
G
V
Q
L
L
A
P
Y
F
Q
E
G
R
L
L
N
V
A
H
Q
Y
Q
Q
V
S
D
W
H
T
R
T
P
A
G
-
7
PsiBlast_PDB
90.91
28%
-69
- C6 -
2DF4
-
GATA_STAAM
A:
[33-474]
-----------------------------------
I
E
E
T
D
P
T
I
K
S
F
L
A
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
--
L
Q
A
K
D
Q
M
DG
K
L
F
-
G
I
P
M
G
I
K
D
N
I
I
T
-
N
-
G
L
E
T
T
C
A
-
S
K
M
L--
E
G
--
F
V
-
P
I
Y
E
S
T
--------
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
M
G
G
S
T
E
T
S
Y
F
K
K
T
V
N
P
F
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
----------
A
I
S
G
A
D
VND
S
T
S
A
P
V
D
-------
D
--------
V
D
F
T
---
S
E
I
G
K
D
I
K
G
L
K
V
A
L
-
P
K
E
Y
------------
L
G
E
G
V
A
D
D
V
K
E
A
V
Q
N
---
A
V
E
T
L
K
S
L
G
--------
A
V
V
E
E
V
S
L
----
P
N
T
---------------
K
F
G
--
I
P
S
Y
------
Y
V
I
A
S
S
E
A
S
----------------------
S
N
L
SRFDGIRYGYHSK---
E
A
-------------------------
H
-----------
S
L
E
E
L
Y
K
M
S
R
S
E
--
G
F
G
K
------
E
V
K
R
R
I
F
L
G
T
-----
F
A
L
SSG
Y
Y
D
A
Y
Y
K
K
-------------
S
Q
K
V
R
T
--
L
I
K
N
D
F
D
K
V
F
E
-
N
Y
D
V
V
V
G
P
------------
T
A
P
T
T
A
F
N
L
G
E
-----------------------
E
I
--
D
D
P
L
T
M
Y
A
N
D
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
--
C
G
-
Q
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
------------
19
PsiBlast_PDB
90.86
26%
-73
* C6 *
4YJI
2
?
A:
[10-485]
-------
W
K
S
A
A
E
I
V
E
L
V
K
S
K
Q
I
S
P
R
E
V
V
E
S
T
I
D
L
I
E
Q
R
D
P
G
L
N
A
V
V
Y
K
A
Y
D
E
A
R
E
K
A
A
A
L
E
R
R
-
I
M
Q
G
E
P
V
--
G
M
L
A
G
V
P
T
L
M
K
D
---
L
-
F
-
A
A
K
P
G
W
P
-
S
T
L
---
G
G
--
I
R
-
A
L
K
D
A
R
G
A
A
GVWS
T
Y
P
L
K
M
S
G
E
D
S
L
L
L
G
Q
T
N
S
P
V
Y
G
F
R
G
T
T
D
N
T
F
F
G
P
T
R
N
P
F
N
L
D
F
N
A
G
G
S
S
G
G
A
A
A
L
V
A
D
G
I
V
P
V
A
G
G
T
D
G
G
G
A
I
R
I
P
A
A
W
T
N
T
Y
G
F
Q
P
S
I
G
R
V
P
F
K
S
---
R
P
N
A
F
H
PG-
P
-----
Y
L
Y
E
G
P
I
T
R
T
V
R
D
A
A
L
A
M
N
V
L
H
G
F
D
RRDP
A
--------
S
L
R
V
----------
K
--------
L
D
F
T
---
S
A
L
A
Q
G
V
R
G
K
K
I
G
L
-
T
L
N
Y
----
G
--
V
----
F
P
V
Q
Q
E
I
Q
D
L
--
I
G
K
---
A
A
R
V
F
T
E
L
G
-----
A
-
H
V
E
F
V
D
L
G
I
----
P
Y
S
Q
K
Q
M
S
D
A
W
C
R
M
I
A
I
P
T
V
A
S
M
Q
A
L
R
------
K
E
G
I
D
L
Y
G
E
----------------------
H
------------------
R
A
-------------------------
D
I----------
P
-------
D
A
L
M
--
K
W
I
D
------
A
V
A
D
---
I
--------------
S
V
Q
Q
I
S
A
-------------
D
Q
L
L
R
T
--
T
V
F
D
C
M
N
G
V
F
D
-
R
F
D
L
L
L
A
P
TLACMPVRNATD
G
C
T
E
G
P
S
Q
I
N
G
E
E
---------
I
D
P
---------
L
I
--
G
W
C
M
T
Y
L
T
--------
N
F
S
G
H
P
S
A
S
V
P
--
A
G
L
I
-
D
G
L
P
A
G
M
L
I
I
G
D
R
Q
A
D
L
D
V
I
A
A
S
A
A
F
E
R
A
S
P
W
S
Q
------
1
PsiBlast_PDB
90.79
31%
-59
- C6 -
3H0L
-
GATA_AQUAE
A:
[12-462]
---------------
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
D
R
Y
N
Q
T
E
E
K
V
K
A
Y
I
T
P
L
Y
G
K
A
L
K
Q
A
E
S
L
K
E
R
------
E
L
--
P
L
F
-
G
I
P
I
A
V
K
D
N
I
L
V
-
E
-
G
E
K
T
T
C
A
-
S
K
I
L--
E
N
--
F
V
-
A
P
Y
D
A
T
--------
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
M
G
S
S
T
E
Y
S
A
F
F
P
T
K
N
P
W
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
R
Y
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
----------
V
I
SGWDEKD
S
T
S
A
K
V
P
-------
V
--------
P
E
W
S
---
E
E
V
K
K
E
V
K
G
L
K
I
G
L
-
P
K
E
F
F
E
YE
L
--
Q
---
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
---
E
G
F
E
I
K
E
V
S
-----
L
P
H
V
K
Y
S
I
P
T
Y
Y
I
I
A
P
S
E
---------------
A
S
S
N
-
L
A
R
-------
Y
D
G
V
R
Y
G
Y
R
----------------------
A
------------------
K
E
-------------------------
Y
-----------
K
-------
D
I
F
E
M
Y
A
R
T
R
D
E
G
F
G
P
E
V
K
R
R
I
M
L
G
T
-----
F
A
L
SAG
Y
Y
D
A
Y
Y
L
K
-------------
A
Q
K
V
R
R
--
L
I
T
N
D
F
L
K
A
F
E
-
E
V
D
V
I
A
S
P
------------
T
T
P
T
L
P
F
K
F
G
E
-
R
---------
L
E
N
---------
P
I
--
E
M
Y
L
S
D
I
L
T
V
P
A
----
N
L
A
G
L
P
A
I
S
I
P
IA
W
K
---
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
-----------------
27
PsiBlast_CBE
90.74
31%
-61
- C6 -
3H0R
1
GATA_AQUAE
D:
[12-462]
---------------
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
D
R
Y
N
Q
T
E
E
K
V
K
A
Y
I
T
P
L
Y
G
K
A
L
K
Q
A
E
S
L
K
E
R
------
E
L
--
P
L
F
-
G
I
P
I
A
V
K
D
N
I
L
V
-
E
-
G
E
K
T
T
C
A
-
S
K
I
L--
E
N
--
F
V
-
A
P
Y
D
A
T
--------
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
M
G
S
S
T
E
Y
S
A
F
F
P
T
K
N
P
W
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
R
Y
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
----------
V
ISGWDEKD
S
T
S
A
K
V
P
-------
V
--------
P
E
W
S
---
E
E
V
K
K
E
V
K
G
L
K
I
G
L
-
P
K
E
F
FEYE
L
--
Q
---
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
---
E
G
F
E
I
K
E
V
S
-----
L
P
H
V
K
Y
S
I
P
T
Y
YIIA
P
S
E
---------------
A
S
S
N
-
L
A
R
-------
Y
D
G
V
R
Y
G
Y
R
----------------------
A
------------------
K
E
-------------------------
Y
-----------
K
-------
D
I
F
E
MY
A
R
T
R
DEGFGP
E
V
K
R
RIM
L
G
T
-----
F
ALSAG
Y
Y
D
A
Y
Y
L
K
-------------
A
Q
K
V
R
R
--
L
I
T
N
D
F
L
K
A
F
E
-
E
V
D
V
I
A
S
P
------------
T
T
P
T
L
P
F
K
F
G
E
-
R
---------
L
E
N
---------
P
I
--
E
M
Y
L
S
D
I
L
T
V
P
A
----
N
L
A
G
L
P
A
I
S
I
P
IA
W
K
---
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
-----------------
34
PsiBlast_CBE
90.68
31%
-61
- C6 -
3H0M
1
GATA_AQUAE
D:
[12-462]
---------------
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
D
R
Y
N
Q
T
E
E
K
V
K
A
Y
I
T
P
L
Y
G
K
A
L
K
Q
A
E
S
L
K
E
R
------
E
L
--
P
L
F
-
G
I
P
I
A
V
K
D
N
I
L
V
-
E
-
G
E
K
T
T
C
A
-
S
K
I
L--
E
N
--
F
V
-
A
P
Y
D
A
T
--------
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
M
G
S
S
T
E
Y
S
A
F
F
P
T
K
N
P
W
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
R
Y
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
----------
V
ISGWDEKD
S
T
S
A
K
V
P
-------
V
--------
P
E
W
S
---
E
E
V
K
K
E
V
K
G
L
K
I
G
L
-
P
K
E
F
FEYE
L
--
Q
---
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
---
E
G
F
E
I
K
E
V
S
-----
L
P
H
V
K
Y
S
I
P
T
Y
YIIA
P
S
E
---------------
A
S
S
N
-
L
A
R
-------
Y
D
G
V
R
Y
G
Y
R
----------------------
A
------------------
K
E
-------------------------
Y
-----------
K
-------
D
I
F
E
MY
A
R
T
R
DEGFGP
E
V
K
R
RIM
L
G
T
-----
F
ALSAG
Y
Y
D
A
Y
Y
L
K
-------------
A
Q
K
V
R
R
--
L
I
T
N
D
F
L
K
A
F
E
-
E
V
D
V
I
A
S
P
------------
T
T
P
T
L
P
F
K
F
G
E
-
R
---------
L
E
N
---------
P
I
--
E
M
Y
L
S
D
I
L
T
V
P
A
----
N
L
A
G
L
P
A
I
S
I
P
IA
W
K
---
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
-----------------
2
PsiBlast_PDB
90.54
31%
-59
- C6 -
3H0M
1
GATA_AQUAE
A:
[12-462]
---------------
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
D
R
Y
N
Q
T
E
E
K
V
K
A
Y
I
T
P
L
Y
G
K
A
L
K
Q
A
E
S
L
K
E
R
------
E
L
--
P
L
F
-
G
I
P
I
A
V
K
D
N
I
L
V
-
E
-
G
E
K
T
T
C
A
-
S
K
I
L--
E
N
--
F
V
-
A
P
Y
D
A
T
--------
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
M
G
S
S
T
E
Y
S
A
F
F
P
T
K
N
P
W
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
R
Y
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
----------
V
I
SGWDEKD
S
T
S
A
K
V
P
-------
V
--------
P
E
W
S
---
E
E
V
K
K
E
V
K
G
L
K
I
G
L
-
P
K
E
F
F
E
YE
L
--
Q
---
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
---
E
G
F
E
I
K
E
V
S
-----
L
P
H
V
K
Y
S
I
P
T
Y
Y
I
I
A
P
S
E
---------------
A
S
S
N
-
L
A
R
-------
Y
D
G
V
R
Y
G
Y
R
----------------------
A
------------------
K
E
-------------------------
Y
-----------
K
-------
D
I
F
E
M
Y
A
R
T
R
D
E
G
FG
P
E
V
K
R
R
I
M
L
G
T
-----
F
A
L
SAG
Y
Y
D
A
Y
Y
L
K
-------------
A
Q
K
V
R
R
--
L
I
T
N
D
F
L
K
A
F
E
-
E
V
D
V
I
A
S
P
------------
T
T
P
T
L
P
F
K
F
G
E
-
R
---------
L
E
N
---------
P
I
--
E
M
Y
L
S
D
I
L
T
V
P
A
----
N
L
A
G
L
P
A
I
S
I
P
I
A
W
K
---
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
-----------------
111
HHSearch
90.49
29%
-61
- C6 -
3H0L
-
GATA_AQUAE
A:
[2-476]
-----
L
W
K
K
S
L
S
E
L
R
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
D
R
Y
N
Q
T
E
E
K
V
K
A
Y
I
T
P
L
Y
G
K
A
L
K
Q
A
E
S
L
K
E
------
R
E
L
--
P
L
F
-
G
I
P
I
A
V
K
D
N
I
L
V
-
E
-
G
E
K
T
T
C
A
-
S
K
I
---
L
E
--
N
F
V
A
P
Y
D
A
T
--------
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
M
G
S
S
T
E
Y
S
A
F
F
P
T
K
N
P
W
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
R
Y
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
----------
V
--------
I
S
G
W
D
E
K
-------
D
STSAK
V
P
V
P
E
W
S
---
E
E
V
K
K
E
V
K
G
L
K
I
G
L
-
P
K
E
F
----
F
--
E
---
Y
--
E
-
L
Q
P
Q
V
K
E
A
F
E
N
---
F
I
K
E
L
E
K
E
G
-----
F
-
E
I
K
E
V
S
L
P
H
----
V
K
Y
---------------
S
I
P
----
T
Y
------
Y
I
I
A
P
S
E
A
S
S
N
L
ARYDGVRYGYRAKEYKD
I
F
E
------------------
M
Y
A
R
T
----------------------
R
-----------
D
-------
E
G
F
G
--
P
E
V
K
------
R
R
I
M
---
L
G
T
F
A
L
SA
G
-----
Y
Y
D
A
Y
Y
L
K
-------------
A
Q
K
V
R
R
--
L
I
T
N
D
F
L
K
A
F
E
-
E
V
D
V
I
A
S
P
------------
T
T
P
T
L
P
F
K
F
G
E
R
L
---------
E
N
P
-------------
I
E
---
M
Y
L
S
D
I
L
T
V
P
A
N
L
A
G
L
P
A
I
S
I
P
--
I
A
W
K
-
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
Y
L
W
E
Q
K
F
K
H
Y
E
K
I
P
---
3
PsiBlast_PDB
90.36
31%
-59
- C6 -
3H0R
1
GATA_AQUAE
A:
[12-462]
---------------
E
L
L
K
R
G
E
V
S
P
K
E
V
V
E
S
F
Y
D
R
Y
N
Q
T
E
E
K
V
K
A
Y
I
T
P
L
Y
G
K
A
L
K
Q
A
E
S
L
K
E
R
------
E
L
--
P
L
F
-
G
I
P
I
A
V
K
D
N
I
L
V
-
E
-
G
E
K
T
T
C
A
-
S
K
I
L--
E
N
--
F
V
-
A
P
Y
D
A
T
--------
V
I
E
R
L
K
K
A
G
A
L
I
V
G
K
T
N
L
D
E
F
A
M
G
S
S
T
E
Y
S
A
F
F
P
T
K
N
P
W
D
L
E
R
V
P
G
G
S
S
G
G
S
A
A
S
V
A
V
L
S
A
P
V
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
S
F
C
G
V
I
G
I
K
P
T
Y
G
R
V
S
R
Y
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
V
F
G
R
R
T
E
D
V
A
L
V
L
E
----------
V
I
SGWDEKD
S
T
S
A
K
V
P
-------
V
--------
P
E
W
S
---
E
E
V
K
K
E
V
K
G
L
K
I
G
L
-
P
K
E
F
F
E
YE
L
--
Q
---
P
Q
V
K
E
A
F
E
N
F
I
K
E
L
E
K
---
E
G
F
E
I
K
E
V
S
-----
L
P
H
V
K
Y
S
I
P
T
Y
Y
I
I
A
P
S
E
---------------
A
S
S
N
-
L
A
R
-------
Y
D
G
V
R
Y
G
Y
R
----------------------
A
------------------
K
E
-------------------------
Y
-----------
K
-------
D
I
F
E
M
Y
A
R
T
R
D
E
G
F
G
P
E
V
K
R
R
I
M
L
G
T
-----
F
A
L
SAG
Y
Y
D
A
Y
Y
L
K
-------------
A
Q
K
V
R
R
--
L
I
T
N
D
F
L
K
A
F
E
-
E
V
D
V
I
A
S
P
------------
T
T
P
T
L
P
F
K
F
G
E
-
R
---------
L
E
N
---------
P
I
--
E
M
Y
L
S
D
I
L
T
V
P
A
----
N
L
A
G
L
P
A
I
S
I
P
I
A
W
K
---
D
G
L
P
V
G
G
Q
L
I
G
K
H
W
D
E
T
T
L
L
Q
I
S
-----------------
10
PsiBlast_PDB
89.58
28%
-64
- C6 -
2G5I
-
GATA_STAAM
A:
[33-474]
-----------------------------------
I
E
E
T
D
P
T
I
K
S
F
L
A
L
D
K
E
N
A
I
K
K
A
Q
E
L
D
E
--
L
Q
A
K
D
Q
M
DG
K
L
F
-
G
I
P
M
G
I
K
D
N
I
I
T
-
N
-
G
L
E
T
T
C
A
-
S
K
M
L--
E
G
--
F
V
-
P
I
Y
E
S
T
--------
V
M
E
K
L
H
K
E
N
A
V
L
I
G
K
L
N
M
D
E
F
A
M
G
G
S
T
E
T
S
Y
F
K
K
T
V
N
P
F
D
H
K
A
V
P
G
G
S
S
G
G
S
A
A
A
V
A
A
G
L
V
P
L
S
L
G
S
D
T
G
G
S
I
R
Q
P
A
A
Y
C
G
V
V
G
M
K
P
T
Y
G
R
V
S
R
F
G
---
L
V
A
F
A
S
---
S
-----
L
D
Q
I
G
P
L
T
R
N
V
K
D
N
A
I
V
L
E
----------
A
I
S
G
A
D
VND
S
T
S
A
P
V
D
-------
D
--------
V
D
F
T
---
S
E
I
G
K
D
I
K
G
L
K
V
A
L
-
P
K
E
Y
------------
L
G
E
G
V
A
D
D
V
K
E
A
V
Q
N
---
A
V
E
T
L
K
S
L
G
--------
A
V
V
E
E
V
S
L
----
P
N
T
---------------
K
F
G
--
I
P
S
Y
------
Y
V
I
A
S
S
E
A
S
----------------------
S
N
L
SRFDGIRYGYHSK---
E
A
-------------------------
H
-----------
S
L
E
E
L
Y
K
M
S
R
S
E
--
G
F
G
K
------
E
V
K
R
R
I
F
L
G
T
-----
F
A
L
SSG
Y
Y
D
A
Y
Y
K
K
-------------
S
Q
K
V
R
T
--
L
I
K
N
D
F
D
K
V
F
E
-
N
Y
D
V
V
V
G
P
------------
T
A
P
T
T
A
F
N
L
G
E
-----------------------
E
I
--
D
D
P
L
T
M
Y
A
N
D
L
L
T
T
P
V
N
L
A
G
L
P
G
I
S
V
P
--
C
G
-
Q
S
N
G
R
P
I
G
L
Q
F
I
G
K
P
F
D
E
K
T
L
Y
R
V
A
Y
Q
Y
E
T
------------
113
HHSearch
89.08
32%
-64
- C6 -
3KFU
-
GATA_THET8
E:
[2-467]
---------
L
A
H
E
I
R
A
R
V
A
R
G
E
V
S
P
L
E
V
A
Q
A
Y
L
K
R
V
Q
E
L
D
P
G
L
G
A
F
L
S
L
N
E
-
R
L
L
E
E
A
E
A
V
D
P
-------
G
L
--
P
L
A
-
G
L
V
V
A
V
K
D
N
I
A
T
-
R
-
G
L
R
T
T
A
G
-
S
R
L
---
L
E
--
N
F
V
P
P
Y
E
A
T
--------
A
V
A
R
L
K
A
L
G
A
L
V
L
G
K
T
N
L
D
E
F
G
M
G
S
S
T
E
H
S
A
F
F
P
T
K
N
P
F
D
P
D
R
V
P
G
G
S
S
G
G
S
A
A
A
L
A
A
D
L
A
P
L
A
L
G
S
D
T
G
G
S
V
R
Q
P
A
A
F
C
G
V
Y
G
L
K
P
T
Y
G
R
V
S
R
F
G
---
L
I
A
Y
A
S
---
S
-----
L
D
Q
I
G
P
M
A
R
S
V
R
D
L
A
L
L
M
D
----------
A
--------
A
A
G
P
D
P
L
DATSLDL
P
--------
P
R
F
Q
---
E
A
L
E
G
P
L
P
P
L
R
L
G
V
-
V
R
E
A
----
L
--
A
------
G
-
N
S
P
G
V
E
R
A
L
E
E
---
A
L
K
V
F
R
E
L
G
-----
L
-
S
V
R
E
V
S
W
P
S
----
L
P
Q
---------------
A
L
A
----
A
Y
------
Y
I
L
A
P
A
E
A
S
----------------------
S
------------------
N
L
ARYDGTLYGRRA-------------
A
GEEVEGMMEAT
R
-------
A
L
F
G
--
L
E
V
K
------
R
R
V
L
---
V
G
T
FVLSS
G
-----
Y
Y
E
A
Y
Y
G
R
-------------
A
Q
A
F
R
R
--
R
L
K
A
E
A
Q
A
L
F
R
-
E
V
D
L
L
L
L
P
------------
T
T
P
H
P
A
F
P
F
G
A
R
R
---------
D
P
L
--------------
A
---
M
Y
R
E
D
L
Y
T
V
G
A
N
L
T
G
L
P
A
L
S
F
P
--
A
G
F
E
-
G
H
L
P
V
G
L
Q
L
L
A
P
W
G
E
D
E
R
L
L
R
A
A
L
A
F
E
E
A
T
A
R
A
H
L
K
A
P
L
-
86
PsiBlast_CBE
46.09
41%
-31
- C6 -
3K83
3
FAAH1_RAT
B:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTAVQ
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
45.88
41%
-33
- C6 -
3LJ6
2
FAAH1_RAT
B:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
45.85
41%
-34
- C6 -
3OJ8
2
FAAH1_RAT
B:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTAVQ
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
45.69
41%
-39
- C6 -
3K84
2
FAAH1_RAT
A:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
45.55
41%
-29
- C6 -
3K83
2
FAAH1_RAT
A:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
45.33
41%
-31
- C6 -
3LJ7
2
FAAH1_RAT
A:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
45.18
41%
-32
- C6 -
3LJ6
2
FAAH1_RAT
A:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
44.80
41%
-33
- C6 -
3K84
2
FAAH1_RAT
B:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
44.80
41%
-33
- C6 -
3OJ8
2
FAAH1_RAT
A:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
44.78
41%
-32
- C6 -
3QK5
4
FAAH1_RAT
B:
[142-295]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
44.77
41%
-30
- C6 -
3QKV
1
FAAH1_RAT
B:
[142-295]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
44.76
41%
-29
- C6 -
3LJ7
2
FAAH1_RAT
B:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
44.74
41%
-32
- C6 -
2VYA
4
FAAH1_RAT
B:
[142-295]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
44.71
41%
-31
- C6 -
3K7F
2
FAAH1_RAT
B:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
44.67
41%
-33
- C6 -
3QJ9
3
FAAH1_RAT
A:
[142-295]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
44.60
41%
-30
- C6 -
4DO3
3
FAAH1_RAT
B:
[124-277]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
44.54
41%
-33
- C6 -
4HBP
1
FAAH1_RAT
B:
[105-258]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTAVQ
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
44.53
41%
-33
- C6 -
4HBP
1
FAAH1_RAT
A:
[105-258]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
44.45
41%
-31
- C6 -
4DO3
3
FAAH1_RAT
A:
[124-277]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
44.43
41%
-32
- C6 -
3K7F
2
FAAH1_RAT
A:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
44.23
41%
-30
- C6 -
2WJ1
2
FAAH1_RAT
A:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
44.22
41%
-32
- C6 -
3QJ9
4
FAAH1_RAT
B:
[142-295]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
44.20
41%
-31
- C6 -
2WJ2
2
FAAH1_RAT
B:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTAVQ
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
44.05
41%
-30
- C6 -
2WJ1
2
FAAH1_RAT
B:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTAVQ
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
43.88
41%
-32
- C6 -
3PR0
2
FAAH1_RAT
B:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
43.88
41%
-29
- C6 -
3QK5
2
FAAH1_RAT
A:
[142-295]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
43.83
41%
-33
- C6 -
3QKV
1
FAAH1_RAT
A:
[142-295]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
L
S
F
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
43.77
41%
-31
- C6 -
2WJ2
2
FAAH1_RAT
A:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
43.70
41%
-31
- C6 -
3PR0
2
FAAH1_RAT
A:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
43.56
41%
-31
- C6 -
2WAP
2
FAAH1_RAT
B:
[104-257]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
43.00
41%
-32
- C6 -
4J5P
2
FAAH1_RAT
A:
[128-281]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
42.95
41%
-30
- C6 -
2WAP
2
FAAH1_RAT
A:
[104-257]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
42.26
41%
-26
- C6 -
2VYA
4
FAAH1_RAT
A:
[142-295]
---------------------------------------------------------------------------
L
Y
-
G
V
P
V
S
L
K
E
C
F
S
Y
-
K
-
G
H
D
S
T
L
G
L
S
L
N
---
E
G
--
M
P
-
S
E
S
D
C
V
--------
V
V
Q
V
L
K
L
Q
G
A
V
P
F
V
H
T
N
V
P
Q
S
M
F
S
Y
D
C
S
N
P
L
F
G
Q
T
M
N
P
W
K
S
S
K
S
P
G
G
S
S
G
G
E
G
A
L
I
G
S
G
G
S
P
L
G
L
G
T
D
I
G
G
S
I
R
F
P
S
A
F
C
G
I
C
G
L
K
P
T
G
N
R
L
S
K
S
G
---
L
K
G
C
V
Y
---
G
QTA
V
Q
L
S
L
-
G
P
M
A
R
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------