@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1267c: (2016-04-30 )
MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVINRNRPVGVDALITALWEEWPPSGARASIHSYVSNLRKLLGGAGIDPRVVLAAAPPGYRLSIPDNTCDLGRFVAEKTAGVHAAAAGRFEQASRHLSAALREWRGPVLDDLRDFQFVEPFATALVEDKVLAHTAKAEAEIACGRASAVIAELEALTFEHPYREPLWTQLITAYYLSDRQSDALGAYRRVKTTLADDLGIDPGPTLRALNERILRQQPLDAKKSAKTTAAGTVTVLDQRTMASGQQAVAYLHDIASGRGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERIRSAVTLNDGDHIRICDHEFTFQISAGTHGGT
Atome Classification :
(20 SA)
.........10........20..-------......30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290......--------.300.......310.--......320--------........330...-----....340.......350......--.360.......370....-....380......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAG
S
A
T
V
E
K
R
LDFGLLG
P
L
Q
M
T
I-------DGTPVPSGT
P
K
Q
R
A
V
L
A
M
L
V
INRNRPV
G
V
D
A
L
I
T
A
L
W
E
EWPPSG
A
R
A
S
I
H
S
Y
V
S
N
L
R
K
L
LGGAGIDP
R
V
V
L
A
AAPP
G
Y
R
L
SIPDN
T
C
D
L
G
R
F
V
A
E
K
TAGV
H
A
A
AAG
R
F
E
Q
A
S
R
H
L
S
A
A
L
R
EWRG
P
V
L
D
D
L
R
D
F
Q
F
V
E
P
F
A
T
A
L
V
E
D
K
V
L
A
HTAKA
E
A
E
IACG
R
A
S
A
V
I
A
E
L
E
A
L
TFEHPYRE
P
L
W
T
Q
L
I
T
A
Y
Y
LSDRQS
D
A
L
G
A
Y
R
R
V
K
T
T
L
ADDLGIDPG
P
T
L
R
A
L
N
E
R
I
L
RQQPLDAKKSAKTTAA
G
T
V
T
V
L
D
Q
R
TMAS
G
Q
Q
A
V
A
Y
L
H
D
I
ASG--------RGY
P
L
Q
A
A
A
T
R
IGRL--HDN
D
I
V
LD---------SANVSR
H
H
A
V
I
V
DT-----GT
N
Y
V
I
N
DLRSSN
G
V
H
V
Q
H
E
RI
R
--
S
A
V
TLNDG
D
H
I
R
I
-CDH
E
-
F
T
F
Q
I
SAGTHGGT
24
HHSearch
98.51
100%
-105
- C1 -
2FF4
1
EMBR_MYCTU
A:
[8-386]
-------
E
K
R
L
D
F
G
L
L
G
P
L
Q
M
T
I
-------
D
G
T
P
V
P
S
G
T
P
K
Q
R
A
V
L
A
M
L
V
I
N
R
N
R
P
V
G
V
D
A
L
I
T
A
L
W
E
E
W
P
P
S
G
A
R
A
S
I
H
S
Y
V
S
N
L
R
K
L
L
G
G
A
G
I
D
P
R
V
V
L
A
A
A
P
P
G
Y
R
L
S
I
P
D
N
T
C
D
L
G
R
F
V
A
E
K
T
A
G
V
H
A
A
A
A
G
R
F
E
Q
A
S
R
H
L
S
A
A
L
R
E
W
R
G
P
V
L
D
D
L
R
D
F
Q
F
V
E
P
F
A
T
A
L
V
E
D
K
V
L
A
H
T
A
K
A
E
A
E
I
A
C
G
R
A
S
A
V
I
A
E
L
E
A
L
T
F
E
H
P
Y
R
E
P
L
W
T
Q
L
I
T
A
Y
Y
L
S
D
R
Q
S
D
A
L
G
A
Y
R
R
V
K
T
T
L
A
D
D
L
G
I
D
P
G
P
T
L
R
A
L
N
E
R
I
L
R
Q
Q
P
L
D
A
K
K
S
A
K
T
T
A
A
G
T
V
T
V
L
D
Q
R
T
M
A
S
G
Q
Q
A
V
A
Y
L
H
D
I
A
S
G
--------
R
G
Y
P
L
Q
A
A
A
T
R
I
G
R
L
--
H
D
N
D
I
V
L
D
---------
S
A
N
V
S
R
H
H
A
V
I
V
D
T
-----
G
T
N
Y
V
I
N
D
L
R
S
S
N
G
V
H
V
Q
H
E
R
I
R
--
S
A
V
T
L
N
D
G
D
H
I
R
I
-
C
D
H
E
-
F
T
F
Q
I
S
A
G
T
H
G
--
21
PsiBlast_CBE
97.17
100%
-107
- C1 -
2FF4
2
EMBR_MYCTU
B:
[8-380]
-------
E
K
R
L
D
F
G
L
L
G
P
L
Q
M
T
I
-------
D
G
T
P
V
P
S
G
T
P
K
Q
R
A
V
L
A
M
L
V
I
N
R
N
R
P
V
G
V
D
A
L
I
T
A
L
W
E
E
W
P
P
S
G
A
R
A
S
I
H
S
Y
V
S
N
L
R
K
L
L
G
G
A
G
I
D
P
R
V
V
L
A
A
A
P
P
G
Y
R
L
S
I
P
D
N
T
C
D
L
G
R
F
V
A
E
K
T
A
G
V
H
A
A
A
A
G
R
F
E
Q
A
S
R
H
L
S
A
A
L
R
E
W
R
G
P
V
L
D
D
L
R
D
F
Q
F
V
E
P
F
A
T
A
L
V
E
D
K
V
L
A
H
T
A
K
A
E
A
E
I
A
C
G
R
A
S
A
V
I
A
E
L
E
A
L
T
F
E
H
P
Y
R
E
P
L
W
T
Q
L
I
T
A
Y
Y
L
S
D
R
Q
S
D
A
L
G
A
Y
R
R
V
K
T
T
L
A
D
D
L
G
I
D
P
G
P
T
L
R
A
L
N
E
R
I
L
R
Q
Q
P
L
D
A
K
K
S
A
K
T
T
A
A
G
T
V
T
V
L
D
Q
R
T
M
A
S
G
Q
Q
A
V
A
Y
L
H
D
I
A
S
G
--------
R
G
Y
P
L
Q
A
A
A
T
R
I
G
R
L
--
H
D
N
D
I
V
L
D
---------
S
A
N
V
S
R
H
H
A
V
I
V
D
T
-----
G
T
N
Y
V
I
N
D
L
R
S
S
N
G
V
H
V
Q
H
E
R
I
R
--
S
A
V
T
L
N
D
G
D
H
I
R
I
-
C
D
H
E
-
F
T
F
Q
I
--------
2
PsiBlast_PDB
96.80
100%
-105
- C1 -
2FF4
1
EMBR_MYCTU
A:
[8-386]
-------
E
K
R
L
D
F
G
L
L
G
P
L
Q
M
T
I
-------
D
G
T
P
V
P
S
G
T
P
K
Q
R
A
V
L
A
M
L
V
I
N
R
N
R
P
V
G
V
D
A
L
I
T
A
L
W
E
E
W
P
P
S
G
A
R
A
S
I
H
S
Y
V
S
N
L
R
K
L
L
G
G
A
G
I
D
P
R
V
V
L
A
A
A
P
P
G
Y
R
L
S
I
P
D
N
T
C
D
L
G
R
F
V
A
E
K
T
A
G
V
H
A
A
A
A
G
R
F
E
Q
A
S
R
H
L
S
A
A
L
R
E
W
R
G
P
V
L
D
D
L
R
D
F
Q
F
V
E
P
F
A
T
A
L
V
E
D
K
V
L
A
H
T
A
K
A
E
A
E
I
A
C
G
R
A
S
A
V
I
A
E
L
E
A
L
T
F
E
H
P
Y
R
E
P
L
W
T
Q
L
I
T
A
Y
Y
L
S
D
R
Q
S
D
A
L
G
A
Y
R
R
V
K
T
T
L
A
D
D
L
G
I
D
P
G
P
T
L
R
A
L
N
E
R
I
L
R
Q
Q
P
L
D
A
K
K
S
A
K
T
T
A
A
G
T
V
T
V
L
D
Q
R
T
M
A
S
G
Q
Q
A
V
A
Y
L
H
D
I
A
S
G
--------
R
G
Y
P
L
Q
A
A
A
T
R
I
G
R
L
--
H
D
N
D
I
V
L
D
---------
S
A
N
V
S
R
H
H
A
V
I
V
D
T
-----
G
T
N
Y
V
I
N
D
L
R
S
S
N
G
V
H
V
Q
H
E
R
I
R
--
S
A
V
T
L
N
D
G
D
H
I
R
I
-
C
D
H
E
-
F
T
F
Q
I
S
A
G
T
H
G
--
1
PsiBlast_PDB
96.26
100%
-106
- C1 -
2FEZ
-
EMBR_MYCTU
A:
[10-382]
---------
R
L
D
F
G
L
L
G
P
L
Q
M
T
I
-------
D
G
T
P
V
P
S
G
T
P
K
Q
R
A
V
L
A
M
L
V
I
N
R
N
R
P
V
G
V
D
A
L
I
T
A
L
W
E
E
W
P
P
S
G
A
R
A
S
I
H
S
Y
V
S
N
L
R
K
L
L
G
G
A
G
I
D
P
R
V
V
L
A
A
A
P
P
G
Y
R
L
S
I
P
D
N
T
C
D
L
G
R
F
V
A
E
K
T
A
G
V
H
A
A
A
A
G
R
F
E
Q
A
S
R
H
L
S
A
A
L
R
E
W
R
G
P
V
L
D
D
L
R
D
F
Q
F
V
E
P
F
A
T
A
L
V
E
D
K
V
L
A
H
T
A
K
A
E
A
E
I
A
C
G
R
A
S
A
V
I
A
E
L
E
A
L
T
F
E
H
P
Y
R
E
P
L
W
T
Q
L
I
T
A
Y
Y
L
S
D
R
Q
S
D
A
L
G
A
Y
R
R
V
K
T
T
L
A
D
D
L
G
I
D
P
G
P
T
L
R
A
L
N
E
R
I
L
R
Q
Q
P
L
D
A
K
K
S
A
K
T
T
A
A
G
T
V
T
V
L
D
Q
R
T
M
A
S
G
Q
Q
A
V
A
Y
L
H
D
I
A
S
G
--------
R
G
Y
P
L
Q
A
A
A
T
R
I
G
R
L
--
H
D
N
D
I
V
L
D
---------
S
A
N
V
S
R
H
H
A
V
I
V
D
T
-----
G
T
N
Y
V
I
N
D
L
R
S
S
N
G
V
H
V
Q
H
E
R
I
R
--
S
A
V
T
L
N
D
G
D
H
I
R
I
-
C
D
H
E
-
F
T
F
Q
I
S
A
------
11
PsiBlast_PDB
46.24
33%
-96
- C1 -
3POA
2
A:
[5-96]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
T
L
Q
L
D
D
G
S
G
--------
R
T
Y
Q
L
R
E
G
S
N
I
I
G
R
G
--
Q
D
A
Q
F
R
L
P
---------
D
T
G
V
S
R
R
H
L
E
I
R
W
D
-----
G
Q
V
A
L
L
A
D
L
N
S
T
N
G
T
T
V
N
N
A
P
V
Q
--
E
W
-
Q
L
A
D
G
D
V
I
R
L
-
G
H
S
E
-
I
I
V
R
M
--------
9
PsiBlast_PDB
46.09
32%
-84
- C1 -
4QCJ
-
ODHI_CORGL
A:
[57-137]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
--------
A
R
F
L
L
D
Q
P
T
T
T
A
G
R
H
--
P
E
S
D
I
F
L
D
---------
D
V
T
V
S
R
R
H
A
E
F
R
I
N
-----
E
G
E
F
E
V
V
D
V
G
S
L
N
G
T
Y
V
N
R
E
P
-
R
--
N
A
Q
V
M
Q
T
G
D
E
I
Q
I
-
G
K
F
R
-
L
V
F
----------
48
Fugue
45.82
22%
-93
- C1 -
1WLN
-
A:
[1-120]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
G
S
S
G
P
E
K
L
P
Y
L
V
E
L
S
P
D
GSDSRDKP
K
L
Y
R
L
Q
L
S
V
T
E
V
G
T
E
KF
D
D
N
S
I
Q
L
F
---------
G
P
G
I
Q
P
H
H
C
D
L
T
N
M
-----
D
G
V
V
T
V
T
P
R
S
M
D
A
E
T
Y
V
D
G
Q
R
I
S
--
E
T
T
M
L
Q
S
G
M
R
L
Q
F
G
T
S
H
V
-
F
K
F
V
D
P
S
G
P
S
S
G
-
32
HHSearch
45.59
23%
-114
- C1 -
2PMU
3
?
A:
[10-107]
-----------
V
R
L
T
F
A
D
I
E
L
D
E
ETH
E
V
W
K
A
G
Q
P
V
S
L
-
S
P
T
E
F
T
L
L
R
Y
F
V
I
N
A
G
T
V
L
S
K
P
K
I
L
D
H
V
W
R
Y
D
F
-
G
G
D
V
N
V
V
E
S
Y
V
S
Y
L
R
R
K
I
D
T
G
E
K
--
R
L
L
H
T
L
R
G
V
G
Y
V
L
R
E
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
45.28
34%
-93
- C1 -
3OUN
-
A:
[67-156]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
T
L
Q
L
D
D
G
S
G
--------
R
T
Y
Q
L
R
E
G
S
N
I
I
G
R
G
--
Q
D
A
Q
F
R
L
P
---------
D
T
G
V
S
R
R
H
L
E
I
R
W
D
-----
G
Q
V
A
L
L
A
D
L
N
S
T
N
G
T
T
V
N
N
A
P
V
Q
--
E
-
W
Q
L
A
D
G
D
V
I
R
L
-
G
H
S
E
-
I
I
V
----------
10
PsiBlast_PDB
45.18
33%
-90
- C1 -
3PO8
1
A:
[5-96]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
T
L
Q
L
D
D
G
S
G
--------
R
T
Y
Q
L
R
E
G
S
N
I
I
G
R
G
--
Q
D
A
Q
F
R
L
P
---------
D
T
G
V
S
R
R
H
L
E
I
R
W
D
-----
G
Q
V
A
L
L
A
D
L
N
S
T
N
G
T
T
V
N
N
A
P
V
Q
--
E
W
-
Q
L
A
D
G
D
V
I
R
L
-
G
H
S
E
-
I
I
V
R
M
--------
36
HHSearch
44.70
33%
-93
- C1 -
3PO8
1
A:
[5-98]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
T
L
Q
L
D
D
G
S
G
--------
R
T
Y
Q
L
R
E
G
S
N
I
I
G
R
G
--
Q
D
A
Q
F
R
L
P
---------
D
T
G
V
S
R
R
H
L
E
I
R
W
D
-----
G
Q
V
A
L
L
A
D
L
N
S
T
N
G
T
T
V
N
N
A
P
V
Q
--
E
-
W
Q
L
A
D
G
D
V
I
R
L
-
G
H
S
E
-
I
I
V
R
M
H
P
------
4
PsiBlast_PDB
44.30
36%
-79
- C1 -
2KFU
-
GARA_MYCTU
A:
[66-146]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
--------
S
R
F
L
L
D
Q
A
I
T
S
A
G
R
H
--
P
D
S
D
I
F
L
D
---------
D
V
T
V
S
R
R
H
A
E
F
R
L
E
-----
N
N
E
F
N
V
V
D
V
G
S
L
N
G
T
Y
V
N
R
E
P
V
D
--
S
A
V
L
A
N
-
G
D
E
V
Q
I
-
G
K
F
R
-
L
V
F
----------
30
HHSearch
44.07
13%
-111
- C1 -
2ZXJ
-
WALR_STAAU
A:
[133-232]
-----------
N
E
I
T
I
K
D
I
V
I
Y
P
DAY
S
I
K
K
R
G
E
D
I
E
L
-
T
H
R
E
F
E
L
F
H
Y
L
S
K
H
M
G
Q
V
M
T
R
E
H
L
L
Q
T
V
W
G
Y
D
Y
F
-
G
D
V
R
T
V
D
V
T
I
R
R
L
R
E
K
I
E
D
D
P
S
H
P
E
Y
I
V
T
R
R
G
V
G
Y
F
L
Q
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
43.64
22%
-99
- C1 -
4NHJ
2
?
A:
[17-114]
------------
T
I
S
F
G
S
L
T
I
D
P
VNR
Q
V
M
L
G
G
E
N
V
A
L
-
S
T
A
D
F
D
M
L
W
E
L
A
T
H
A
G
Q
I
M
D
R
D
A
L
L
K
N
L
R
G
V
T
Y
-
D
G
M
D
R
S
V
D
V
A
I
S
R
L
R
K
K
L
L
D
N
A
T
E
P
Y
R
I
K
T
V
R
N
K
G
Y
L
F
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
43.59
36%
-80
- C1 -
2XT9
-
?
B:
[22-102]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
--------
S
R
F
L
L
D
Q
P
T
T
S
A
G
R
H
--
P
D
S
D
I
F
L
D
---------
D
V
T
V
S
R
R
H
A
E
F
R
L
E
-----
G
G
E
F
Q
V
V
D
V
G
S
L
N
G
T
Y
V
N
R
E
P
V
D
--
S
A
V
L
A
N
-
G
D
E
V
Q
I
-
G
K
F
R
-
L
V
F
----------
6
PsiBlast_PDB
43.39
36%
-74
- C1 -
3OUN
-
A:
[73-154]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
G
S
G
--------
R
T
Y
Q
L
R
E
G
S
N
I
I
G
R
G
--
Q
D
A
Q
F
R
L
P
---------
D
T
G
V
S
R
R
H
L
E
I
R
W
D
-----
G
Q
V
A
L
L
A
D
L
N
S
T
N
G
T
T
V
N
N
A
P
V
Q
--
E
-
W
Q
L
A
D
G
D
V
I
R
L
-
G
H
S
E
-
I
------------
53
Fugue
43.13
21%
-97
* C1 *
1GXC
1
CHK2_HUMAN
A:
[29-144]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
W
A
R
L
W
A
L
Q
D
G
F
-------
A
N
L
E
C
V
N
D
N
Y
W
F
G
R
D
--
K
S
C
E
Y
C
F
D
E
P
L
L
K
R
TDK
Y
R
T
Y
S
K
K
H
F
R
I
F
R
E
VGPKN
S
Y
I
A
Y
I
E
D
H
-
S
G
N
G
T
F
V
N
T
E
L
V
G
KG
K
R
R
P
L
N
N
N
S
E
I
A
L
-
S
L
S
R
N
K
V
F
V
F
F
D
L
T
V
D
--
38
HHSearch
42.37
23%
-108
- C1 -
2RV8
-
?
A:
[148-246]
----------
N
V
R
L
T
F
A
D
I
E
L
D
E
ETH
E
V
W
K
A
G
Q
P
V
S
L
-
S
P
T
E
F
T
L
L
R
Y
F
V
I
N
A
G
T
V
L
S
K
P
K
I
L
D
H
V
W
R
Y
D
F
-
G
G
D
V
N
V
V
E
S
Y
V
S
Y
L
R
R
K
I
D
T
G
E
--
K
R
L
L
H
T
L
R
G
V
G
Y
V
L
R
E
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
42.37
18%
-115
- C1 -
3RJP
-
?
A:
[149-227]
------------------------------
G
D
D
E
I
S
L
-
T
K
R
E
Y
D
L
L
N
I
L
M
T
N
M
N
R
V
M
T
R
E
E
L
L
S
N
V
W
K
Y
D
E
-
A
V
E
T
N
V
V
D
V
Y
I
R
Y
L
R
G
K
I
D
I
P
G
K
-
E
S
Y
I
Q
T
V
R
G
M
G
Y
V
I
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
42.13
36%
-89
- C1 -
2KKL
-
Y1858_MYCBO
A:
[66-146]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
--------
S
R
F
L
L
D
Q
A
I
T
S
A
G
R
H
--
P
D
S
D
I
F
L
D
---------
D
V
T
V
S
R
R
H
A
E
F
R
L
E
-----
N
N
E
F
N
V
V
D
V
G
S
L
N
G
T
Y
V
N
R
E
P
V
D
--
S
A
V
L
A
N
-
G
D
E
V
Q
I
-
G
K
F
R
-
L
V
F
----------