@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1273c: (2016-04-30 )
MLLALLRQHIRPYRRLVAMLMMLQLVSTLASLYLPTVNAAIVDDGVAKGDTATIVRLGAVMLGVTGLQVLCAIGAVYLGSRTGAGFGRDLRSAMFEHIITFSERETARFGAPTLLTRSTNDVRQILFLVQMTATVLVTAPIMCVGGIIMAIHQEAALTWLLLVSVPILAVANYWIISHMLPLFRRMQSLIDGINRVMRDQLSGVRVVRAFTREGYERDKFAQANTALSNAALSAGNWQALMLPVTTLTINASSVALIWFGGLRIDSGQMQVGSLIAFLSYFAQILMAVLMATMTLAVLPRASVCAERITEVLSTPAALGNPDNPKFPTDGVTGVVRLAGATFTYPGADCPVLQDISLTARPGTTTAIVGSTGSGKSTLVSLICRLYDVTAGAVLVDGIDVREYHTERLWSAIGLVPQRSYLFSGTVADNLRYGGGPDQVVTEQEMWEALRVAAADGFVQTDGLQTRVAQGGVNFSGGQRQRLAIARAVIRRPAIYVFDDAFSALDVHTDAKVHASLRQVSGDATIIVVTQRISNAAQADQVIVVDNGKIVGTGTHETLLADCPTYAEFAASQSLSATVGGVG
Atome Classification :
(64 SA)
-.........10........20........30........40........50-.--------------------........60........70....----....80........90........100.....--..110---.-----......120.......130.......140......---.150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.---......330.........340....-.-..350........360.......370.......380.......---390.......400-.....--.-..410.......420..-.....-----430.......440.......450...---.....--460.........470.......480.......490.......500.......510.......520.---..-......530.....-..540.......550.......560-........570.......580
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
L
L
A
L
L
R
Q
H
I
R
P
Y
R
R
L
V
A
M
L
M
M
L
Q
L
V
S
T
L
A
S
L
Y
LPTV
N
A
A
I
VDDGVAKGD--
T
--------------------
A
T
I
V
R
L
G
A
V
M
L
G
V
T
G
L
Q
V
L
C
A
I
G
A
----
V
YLGSRTGAGF
G
R
D
L
R
S
A
M
F
E
H
I
I
T
FSERETA--RFGA
P
---
T
-----
L
L
TRST
N
D
V
R
Q
I
L
F
L
V
Q
M
T
A
T
V
L
VT
A
P
I
M
C
V
G
G
I
I
---
M
A
I
H
Q
E
A
A
L
T
W
L
L
L
V
S
V
P
I
L
A
V
A
N
Y
W
I
I
S
H
M
L
P
L
F
R
R
M
Q
S
L
I
D
G
I
N
R
V
M
R
D
Q
LS
G
V
R
V
V
R
A
F
T
REGYER
D
K
FAQANTALSNAALSAGN
W
Q
A
L
M
L
P
V
T
T
L
T
INA
S
S
V
A
L
I
W
F
G
G
L
R
IDSG
Q
M
Q
V
G
S
L
I
A
F
L
S
Y
F
A
Q
I
L
M
A
V
L
M
A
T
M
T
L
A
VLP
R
A
S
V
C
A
E
R
I
T
E
V
LSTPAALGNPDN---PKFPTDG--
V
T
G
V
V
RLAG
A
T
FTYPG-A-DC
P
V
-LQD
I
S
L
TARPG
T
T
T
A
I
V
GSTGS
G
K
S
T
L
V
S
L
I
C
R
L
Y
DVT---A
G
A
V
L
VDGI
D
V
R
--
E
Y
H
T
E
--
R
-
L
W
S
A
IGLVPQR
S
Y
L
FSG-TVADN-----LRYGGGPDQVV
T
E
Q
E
M
W
E
A
L
R
V
-
A
AA---DG
F
V
Q--T--DG
L
Q
T
R
V
A
QGGVNFSGG
Q
R
Q
R
L
A
I
A
R
A
V
IRRP
A
I
Y
V
FDDAF
S
A
LDVHTD
A
K
V
H
A
S
L
R
QVS--G---D
A
-
T
I
I
V
V
T
Q
RISNAAQ-A
D
Q
V
I
V
V
DN
G
K
I
V
GTGTH
E
T
L
LAD--CP
T
Y
A
E
F
A
ASQS
L
S
A
TVGGVG
2
PsiBlast_PDB
93.50
37%
-126
- C1 -
4Q4A
2
?
A:
[14-578]
------
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
--
F
--------------------
S
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
----
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
--
R
F
H
T
S
---
S
-----
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
---
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
---
A
-
L
A
L
P
N
--
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
-
N
-
T
D
P
V
-
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
--
T
V
K
L
K
--
D
-
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
-----
L
K
W
G
---
R
E
D
A
T
D
D
E
I
V
E
A
A
K
I
-
A
Q
I
---
H
D
F
I
I
--
S
LP
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
--
K
---
G
C
-
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
----------
1
PsiBlast_PDB
92.45
37%
-127
- C1 -
3QF4
2
?
A:
[14-578]
------
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
--
F
--------------------
S
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
----
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
--
R
F
H
T
S
---
S
-----
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
---
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
---
A
-
L
A
L
P
N
--
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
-
N
-
T
D
P
V
-
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
--
T
V
K
L
K
--
D
-
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
-----
L
K
W
G
---
R
E
D
A
T
D
D
E
I
V
E
A
A
K
I
-
A
Q
I
---
H
D
F
I
I
--
S
LP
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
--
K
---
G
C
-
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
----------
119
HHSearch
91.31
37%
-126
- C1 -
4Q4H
-
?
A:
[4-569]
------
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
--
F
--------------------
S
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
----
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
--
R
F
H
T
S
---
S
-----
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
---
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
---
A
L
A
-
L
P
N
--
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
-
N
-
T
D
P
V
-
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
--
T
V
K
L
K
--
D
-
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
-----
L
K
W
G
R
E
---
D
A
T
D
D
E
I
V
E
A
A
K
I
-
A
Q
I
---
H
D
F
I
I
S
L
P
--
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
--
K
---
G
C
-
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
---------
3
PsiBlast_PDB
90.74
37%
-126
- C1 -
4Q4H
-
?
A:
[4-568]
------
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
--
F
--------------------
S
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
----
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
--
R
F
H
T
S
---
S
-----
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
---
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
---
A
-
L
A
L
P
N
--
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
-
N
-
T
D
P
V
-
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
--
T
V
K
L
K
--
D
-
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
-----
L
K
W
G
---
R
E
D
A
T
D
D
E
I
V
E
A
A
K
I
-
A
Q
I
---
H
D
F
I
I
--
S
LP
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
--
K
---
G
C
-
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
----------
4
PsiBlast_PDB
89.84
36%
-124
- C1 -
4Q4J
-
?
A:
[4-568]
------
L
A
R
Y
L
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
S
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
--
F
--------------------
S
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
S
----
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
--
R
F
H
T
S
---
S
-----
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
---
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
---
A
-
L
A
L
P
N
--
V
E
G
S
V
S
F
E
N
V
E
F
R
Y
F
E
-
N
-
T
D
P
V
-
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
--
T
V
K
L
K
--
D
-
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
E
N
-----
L
K
W
G
---
R
E
D
A
T
D
D
E
I
V
E
A
A
K
I
-
A
Q
I
---
H
D
F
I
I
--
S
LP
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
S
T
C
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
T
--
K
---
G
S
-
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
--
S
K
P
Y
R
E
I
Y
E
S
Q
----------
117
HHSearch
78.68
28%
-119
- C1 -
4Q4H
-
Y288_THEMA
B:
[28-592]
------
L
L
G
Y
L
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
--
F
--------------------
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
----
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
--
R
T
P
H
G
---
D
-----
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
---
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
---
V
--
E
L
R
E
--
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
D
K
-
K
--
K
P
V
-
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
--
K
I
K
R
S
--
S
-
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
-
T
V
K
E
N
-----
L
K
Y
G
N
P
---
G
A
T
D
E
E
I
K
E
A
A
K
L
-
T
H
S
---
D
H
F
I
K
H
L
P
--
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
---
G
K
-
T
S
I
I
I
A
H
R
L
N
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
--------
122
HHSearch
75.03
27%
-118
- C1 -
3WMG
5
?
A:
[28-598]
----------------
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
Q
I
E
--------------------
G
E
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
----
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
--
R
R
K
A
G
---
E
-----
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
G
-
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
---
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
Y
R
R
P
D
P
G
A
E
V
V
T
Q
P
L
V
--
L
K
Q
G
I
V
F
E
N
V
H
F
R
Y
P
T
-
R
M
N
V
E
V
-
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
--
N
Y
D
F
H
--
A
-
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
-
T
I
R
D
N
-----
I
L
Y
G
K
R
---
D
A
T
D
E
E
V
I
Q
A
L
R
E
-
A
N
A
---
Y
S
F
V
M
A
L
P
--
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
---
G
V
-
T
S
V
V
I
A
H
R
L
S
T
V
A
R
-
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
-------
103
Fugue
73.89
27%
-112
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
--
R
--------------------
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
----
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
--
K
Q
S
T
G
---
T
-----
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
---
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
---
E
K
D
E
---
G
K
R
V
I
D
R
--
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
-
R
-
E
V
P
A
-
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
--
E
Y
T
L
A
--
S
-
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
-----
I
A
Y
A
R
T
E
E
--
Y
S
R
E
Q
I
E
E
A
A
R
M
-
A
Y
A
---
M
D
F
I
N
K
M
D
--
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
---
N
R
-
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
--------
116
HHSearch
73.25
28%
-113
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[8-572]
----
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--
V
DY
S
-----------------
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
----
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
--
K
T
R
T
G
---
E
-----
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
---
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
---
V
I
L
N
E
K
S
--
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
-
R
P
E
V
P
I
-
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
N
P
V
--
W
-
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
-----
I
A
Y
G
A
D
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
-
A
N
A
---
V
A
F
I
R
N
F
P
--
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
---
G
R
-
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P----------------------
15
PsiBlast_PDB
73.03
29%
-113
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[16-571]
------------
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--
V
--------------------
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
-
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
---
R
Q
E
V
A
--
F
F
D
K
T
R
T
G
E
-----
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
---
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
---
V
I
L
N
E
K
S
--
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
-
E
V
P
I
-
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
N
P
V
--
W
-
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
-----
I
A
Y
G
A
D
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
-
A
N
A
---
V
A
F
I
R
--
N
FP
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
---
G
R
-
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
-----------------------
126
HHSearch
71.86
25%
-121
- C1 -
4Q9H
-
MDR1A_MOUSE
A:
[47-687]
--------------
R
L
Y
M
L
V
G
T
L
A
A
I
I
H
G
V
A
L
P
L
M
M
L
I
F
G
D
M
T
D
S
F
A
S
V
G
Q
--
V
S
K
Q
S
TQMS
E
A
D
K
R
A
M
F
A
K
L
E
E
E
M
T
T
Y
A
Y
Y
Y
T
G
I
G
A
G
V
L
I
V
A
Y
I
Q
----
V
S
F
W
C
L
A
A
G
R
Q
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
--
V
H
D
V
G
---
E
-----
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
---
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
P
S
I
D
S
F
S
K
---
S
G
H
K
P
D
N
--
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
-
R
K
E
V
Q
I
-
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
--
T
I
N
V
R
--
Y
-
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
-
T
I
A
E
N
-----
I
R
Y
G
R
E
---
D
V
T
M
D
E
I
E
K
A
V
K
E
-
A
N
A
---
Y
D
F
I
M
K
L
P
--
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
--
E
---
G
R
-
T
T
I
V
I
A
H
R
L
S
T
V
R
N
-
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
--
K
G
I
Y
F
K
L
V
M
T
Q
----------
114
HHSearch
71.72
27%
-111
- C1 -
3B60
2
MSBA_SALTY
A:
[17-580]
-------
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
--
R
--------------------
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
----
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
--
K
Q
S
T
G
---
T
-----
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
---
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
R
-----
V
-
I
D
R
--
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
-
R
-
E
V
P
A
-
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
--
E
Y
T
L
A
--
S
-
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
N
N
-----
I
A
Y
A
R
T
E
--
E
Y
S
R
E
Q
I
E
E
A
A
R
M
-
A
Y
A
---
M
D
F
I
N
K
M
D
--
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
---
N
R
-
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
---------
14
PsiBlast_PDB
71.67
29%
-113
- C1 -
4AYX
7
ABCBA_HUMAN
A:
[16-571]
------------
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--
V
--------------------
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
-
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
---
R
Q
E
V
A
--
F
F
D
K
T
R
T
G
E
-----
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
---
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
---
V
I
L
N
E
K
S
--
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
-
E
V
P
I
-
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
N
P
V
--
W
-
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
-----
I
A
Y
G
A
D
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
-
A
N
A
---
V
A
F
I
R
--
N
FP
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
---
G
R
-
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
-----------------------
13
PsiBlast_PDB
71.56
29%
-113
- C1 -
4AYT
8
ABCBA_HUMAN
A:
[16-567]
------------
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--
V
--------------------
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
-
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
---
R
Q
E
V
A
--
F
F
D
K
T
R
T
G
E
-----
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
---
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
---
V
I
L
N
E
K
S
--
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
-
E
V
P
I
-
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
N
P
V
--
W
-
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
-----
I
A
Y
G
A
D
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
-
A
N
A
---
V
A
F
I
R
--
N
FP
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
---
G
R
-
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------------
125
HHSearch
71.49
28%
-118
- C1 -
4Q9H
-
MDR1A_MOUSE
A:
[762-1273]
------------------------------------------------------------------------------------------
S
F
I
T
F
F
L
Q
----
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
M
L
R
Q
D
V
S
W
F
D
DP
K
N
T
T
G
---
A
-----
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
---
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
Q
S
L
Q
I
P
Y
R
N
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
Q
L
M
T
F
E
N
V
L
L
V
F
S
A
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
K
T
P
E
I
D
S
Y
S
T
---
Q
G
L
K
P
N
M
--
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
-
R
P
S
I
P
V
-
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
--
Q
L
N
V
Q
--
W
-
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
-----
I
A
Y
G
D
N
S
R
-
V
V
S
Y
E
E
I
V
R
A
A
K
E
-
A
N
I
---
H
Q
F
I
D
S
L
P
--
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
---
G
R
-
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
-
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
F
S
M
V
S
V
Q
A
G
A
-------
5
PsiBlast_PDB
71.46
29%
-107
- C1 -
2HYD
3
Y1866_STAAM
A:
[83-578]
-------------------------------------------------------------------------------------------------------
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
--
N
N
Q
V
G
---
Q
-----
V
I
S
R
V
I
N
D
V
E
Q
T
---
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
G
---
A
Q
-
P
I
E
I
--
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
-
N
-
E
A
P
I
-
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
--
D
F
L
T
G
--
S
-
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
-----
I
L
L
G
---
R
P
T
A
T
D
E
E
V
V
E
A
A
K
M
-
A
N
A
---
H
D
F
I
M
--
N
LP
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
---
D
R
-
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
--------
6
PsiBlast_PDB
70.95
29%
-107
- C1 -
2ONJ
4
Y1866_STAAM
A:
[83-578]
-------------------------------------------------------------------------------------------------------
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
--
N
N
Q
V
G
---
Q
-----
V
I
S
R
V
I
N
D
V
E
Q
T
---
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
G
---
A
Q
-
P
I
E
I
--
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
-
N
-
E
A
P
I
-
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
--
D
F
L
T
G
--
S
-
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
E
N
-----
I
L
L
G
---
R
P
T
A
T
D
E
E
V
V
E
A
A
K
M
-
A
N
A
---
H
D
F
I
M
--
N
LP
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
---
D
R
-
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
--------
113
HHSearch
70.65
22%
-123
- C1 -
4RY2
-
?
A:
[162-724]
----------
L
K
P
L
K
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
--
L
--------------------
N
D
L
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
----
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
--
S
R
K
V
G
---
E
-----
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
---
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
-----------------
G
D
I
E
F
R
N
V
D
F
R
Y
G
L
-
R
--
K
P
V
-
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
--
N
I
S
L
E
--
L
-
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
-
T
V
K
E
N
-----
L
C
L
G
N
E
---
N
V
D
M
D
E
I
I
K
A
A
K
M
-
A
N
A
---
H
D
F
I
E
K
L
P
--
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
---
D
V
-
T
V
I
I
I
A
H
R
L
S
T
I
V
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
G
C
Y
F
K
M
W
K
Q
T
E
N
T
-------
16
PsiBlast_PDB
70.48
29%
-114
- C1 -
4AYW
3
ABCBA_HUMAN
A:
[47-598]
------------
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--
V
--------------------
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
-
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
---
R
Q
E
V
A
--
F
F
D
K
T
R
T
G
E
-----
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
---
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
---
V
I
L
N
E
K
S
--
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
-
E
V
P
I
-
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
L
N
P
V
--
W
-
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
E
N
-----
I
A
Y
G
A
D
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
-
A
N
A
---
V
A
F
I
R
--
N
FP
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
---
G
R
-
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
---------------------------
19
PsiBlast_PDB
69.97
28%
-118
- C1 -
4Q9I
-
MDR1A_MOUSE
A:
[775-1271]
-----------------------------------------------------------------------------------------------------------
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
M
L
---
R
Q
D
V
S
--
W
F
D
D
P
---
K
NT
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
---
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
Q
S
L
Q
I
P
Y
R
N
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
Q
L
M
T
F
E
N
V
L
L
V
F
S
A
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
K
T
P
E
I
D
S
Y
S
T
---
Q
G
L
K
P
N
M
--
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
P
-
S
I
P
V
-
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
--
Q
L
N
V
Q
--
W
-
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
-----
I
A
Y
G
D
N
-
S
R
V
V
S
Y
E
E
I
V
R
A
A
K
E
-
A
N
I
---
H
Q
F
I
D
--
S
LP
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
---
G
R
-
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
-
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
F
S
M
V
S
V
Q
A
---------
66
PsiBlast_CBE
54.41
33%
-115
- C1 -
2IXE
3
D:
[13-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
-
N
V
Q
V
-
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
--
Q
Y
D
H
H
--
Y
-
L
H
T
Q
V
A
A
V
G
--
P
L
L
F
G
R
-
S
F
R
E
N
-----
I
A
Y
--
G
L
T
R
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
A
---
H
D
F
I
S
GF
P
--
Q
G
Y
D
T
E
V
-----
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
EW
A
---
S
R
-
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
-----------------
29
PsiBlast_CBE
54.38
37%
-119
- C1 -
5DGX
1
A:
[15-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
G
N
V
T
I
K
D
L
S
F
A
F
---
G
-
E
H
K
V
-
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
---
E
G
E
I
L
L
D
G
V
D
T
R
--
E
L
T
L
E
--
N
-
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
D
D
-
T
V
Y
N
N
-----
I
A
F
G
-----
E
V
S
E
E
E
V
I
D
A
L
K
R
-
A
N
A
---
Y
E
F
V
Q
E
L
S
--
D
G
I
N
T
N
I
G
N
N
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
----------------
L
E
S
L
T
--
K
---
S
C
-
T
T
I
V
I
A
H
R
L
S
T
V
E
N
-
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
--
G
G
L
Y
T
R
L
Y
Q
S
-----------
73
PsiBlast_CBE
52.63
32%
-110
- C1 -
2IXG
2
A:
[13-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
-
N
V
Q
V
-
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
--
Q
Y
D
H
H
--
Y
-
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
E
N
-----
I
A
Y
--
G
L
T
R
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
A
---
H
D
F
I
S
G
F
P
--
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
A
V
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
EW
A
---
S
R
-
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
-----------------
68
PsiBlast_CBE
52.17
32%
-109
- C1 -
2IXF
4
D:
[13-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
-
N
V
Q
V
-
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
--
Q
Y
D
H
H
--
Y
-
L
H
T
Q
V
A
A
V
G
Q
--
L
L
F
G
R
-
S
F
R
E
N
-----
I
A
Y
--
G
L
T
R
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
A
---
H
D
F
I
S
GF
P
--
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
EW
A
---
S
R
-
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
-----------------
69
PsiBlast_CBE
52.14
32%
-113
- C1 -
2IXF
4
TAP1_RAT
C:
[13-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
-
N
V
Q
V
-
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
--
Q
Y
D
H
H
--
Y
-
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
E
N
-----
I
A
Y
--
G
L
T
R
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
A
---
H
D
F
I
S
GF
P
--
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
EW
A
---
S
R
-
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
-----------------
47
PsiBlast_CBE
51.75
34%
-116
- C1 -
3VX4
3
?
A:
[29-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SF
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
-
G
-
F
-
G
R
D
T
-
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
--
V
I
D
K
T
--
A
-
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
-
S
I
M
D
N
-----
L
V
L
G
A
--
K
E
G
T
S
Q
E
D
I
I
R
A
C
E
I
-
A
E
I
---
R
S
D
I
E
--
Q
MP
Q
G
Y
Q
T
E
L
S
D
G
A
-
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
T
------
E
K
-
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
G
F
Y
-----------------
58
PsiBlast_CBE
51.65
36%
-122
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[9-234]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
70
PsiBlast_CBE
51.59
32%
-109
- C1 -
2IXF
4
TAP1_RAT
B:
[13-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
-
N
V
Q
V
-
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
--
Q
Y
D
H
H
--
Y
-
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
E
N
-----
I
A
Y
--
G
L
T
R
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
A
---
H
D
F
I
S
G
F
P
--
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
EW
A
---
S
R
-
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
-----------------
60
PsiBlast_CBE
51.31
36%
-117
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[9-234]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
53
PsiBlast_CBE
51.27
36%
-118
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[15-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
71
PsiBlast_CBE
50.99
32%
-110
- C1 -
2IXF
5
TAP1_RAT
A:
[13-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
-
N
V
Q
V
-
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
--
Q
Y
D
H
H
--
Y
-
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
E
N
-----
I
A
Y
--
G
L
T
R
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
A
---
H
D
F
I
S
G
F
P
--
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
EW
A
---
S
R
-
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
-----------------
72
PsiBlast_CBE
50.81
32%
-112
- C1 -
4K8O
4
A:
[13-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
-
N
V
Q
V
-
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
--
Q
Y
D
H
H
--
Y
-
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
E
N
-----
I
A
Y
--
G
L
T
R
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
A
---
H
D
F
I
S
G
F
P
--
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
A
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
EW
A
---
S
R
-
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
-----------------
62
PsiBlast_CBE
50.57
36%
-113
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[15-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
52
PsiBlast_CBE
50.47
36%
-119
- C1 -
2FGJ
2
D:
[15-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
64
PsiBlast_CBE
50.15
36%
-113
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[15-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
67
PsiBlast_CBE
49.73
33%
-104
- C1 -
2IXE
4
TAP1_RAT
A:
[13-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
-
N
V
Q
V
-
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
--
Q
Y
D
H
H
--
Y
-
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
E
N
-----
I
A
Y
--
G
L
T
R
T
P
T
M
E
E
I
T
A
V
A
M
E
-
S
G
A
---
H
D
F
I
S
G
F
P
--
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
---
S
R
-
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
G
C
Y
-----------------
54
PsiBlast_CBE
49.47
36%
-115
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[15-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
55
PsiBlast_CBE
49.16
36%
-118
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[15-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
63
PsiBlast_CBE
49.04
36%
-116
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[15-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
59
PsiBlast_CBE
49.03
36%
-116
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[9-234]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
45
PsiBlast_CBE
49.02
35%
-100
- C1 -
1JJ7
2
A:
[11-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
L
V
Q
F
Q
D
V
S
F
A
Y
P
N
R
P
-
D
V
L
V
-
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
Q
L
L
L
D
G
K
P
L
P
--
Q
Y
E
H
R
--
Y
-
L
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
G
R
-
S
L
Q
E
N
-----
I
A
Y
G
L
--
T
Q
K
P
T
M
E
E
I
T
A
A
A
V
K
-
S
G
A
---
H
S
F
I
S
G
L
P
--
Q
G
Y
D
T
E
V
D
E
A
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
P
--
E
RY-
S
R
-
S
V
L
L
I
T
Q
H
L
S
L
V
E
Q
-
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
K
--
K
G
C
Y
-----------------
57
PsiBlast_CBE
49.00
36%
-115
- C1 -
1XEF
3
D:
[9-234]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
61
PsiBlast_CBE
48.97
36%
-116
- C1 -
2FGK
2
D:
[15-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
56
PsiBlast_CBE
48.67
36%
-110
- C1 -
2FFA
2
A:
[15-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
49
PsiBlast_CBE
48.43
36%
-111
- C1 -
2FF7
1
A:
[15-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
65
PsiBlast_CBE
47.68
36%
-109
- C1 -
2FFB
1
A:
[15-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
48
PsiBlast_CBE
47.48
36%
-113
- C1 -
2PMK
1
A:
[11-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
51
PsiBlast_CBE
45.53
36%
-110
- C1 -
3B5J
1
A:
[11-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Y
K
--
P
-
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
--
L
A
D
P
N
--
W
-
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
-----
I
S
L
A
N
-
P
G
M
S
V
--
E
K
V
I
Y
A
A
K
L
-
A
G
A
---
H
D
F
I
S
--
E
LR
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
---
G
R
-
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
--------------
75
PsiBlast_CBE
42.23
31%
-97
- C1 -
2CBZ
2
A:
[9-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
F
T
W
A
R
-
S
-
D
P
P
T
-
L
N
G
I
T
F
S
I
P
E
G
A
L
V
A
V
V
G
Q
V
G
C
G
K
S
S
L
L
S
A
L
L
A
E
M
D
K
V
---
E
G
H
V
A
I
K
G
------------------
S
V
A
Y
V
P
Q
Q
A
W
I
Q
N
D
-
S
L
R
E
N
-----
I
L
F
G
-----
C
Q
L
E
E
P
Y
Y
R
S
V
I
Q
-
A
C
A
L
L
P
D
L
E
I
L
--
P
--
S
G
D
R
T
E
I
G
E
K
G
V
N
L
S
G
G
Q
K
Q
R
V
S
L
A
R
A
V
Y
S
N
A
D
I
Y
L
F
D
D
P
L
S
A
V
D
A
H
V
G
K
H
I
F
E
N
V
I
G
P
K
--
G
MLK
N
K
-
T
R
I
L
V
T
H
S
M
S
Y
L
P
Q
-
V
D
V
I
I
V
M
S
G
G
K
I
S
E
M
G
S
Y
Q
E
L
L
A
R
--
D
G
A
F
A
E
F
--------------
80
PsiBlast_CBE
38.15
32%
-95
- C1 -
4YMV
1
?
J:
[16-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
N
NG
K
V
N
I
N
--
K
-
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
-----
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
-----
A
V
---
D
L
L
A
K
--
V
---
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------
102
PsiBlast_CBE
37.87
31%
-95
- C1 -
2OLJ
4
?
A:
[39-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
N
L
N
K
-
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-----
I
T
L
A
--
P
M
K
V
----
R
K
W
P
R
E
K
A
E
A
K
A
---
M
E
L
L
D
--
K
--
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-
D
--
R
P
Q
H
E
R
T
K
A
------------
100
PsiBlast_CBE
37.18
31%
-94
- C1 -
2OLK
1
?
A:
[39-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
N
L
N
K
-
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-----
I
T
L
A
--
P
M
K
V
----
R
K
W
P
R
E
K
A
E
A
K
A
---
M
E
L
L
D
--
K
--
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-
D
--
R
P
Q
H
E
R
T
K
A
------------
82
PsiBlast_CBE
36.95
32%
-92
- C1 -
4YMU
2
?
J:
[16-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
N
NG
K
V
N
I
N
--
K
-
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
-----
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
-----
A
V
---
D
L
L
A
K
--
V
---
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------
83
PsiBlast_CBE
36.74
32%
-95
- C1 -
4YMU
2
?
A:
[16-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
N
NG
K
V
N
I
N
--
K
-
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
-----
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
-----
A
V
---
D
L
L
A
K
--
V
---
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------
97
PsiBlast_CBE
36.55
31%
-96
- C1 -
2OLK
1
?
D:
[39-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
N
LN
K
-
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-----
I
T
L
A
--
P
M
K
V
----
R
K
W
P
R
E
K
A
E
A
K
A
---
M
E
L
L
D
--
K
--
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-
D
--
R
P
Q
H
E
R
T
K
A
------------
81
PsiBlast_CBE
36.43
32%
-90
- C1 -
4YMV
1
?
A:
[16-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
N
NG
K
V
N
I
N
--
K
-
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
-----
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
-----
A
V
---
D
L
L
A
K
--
V
---
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------
92
PsiBlast_CBE
35.74
31%
-91
- C1 -
2Q0H
4
?
A:
[39-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
N
L
N
K
-
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-----
I
T
L
A
--
P
M
K
V
----
R
K
W
P
R
E
K
A
E
A
K
A
---
M
E
L
L
D
--
K
--
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-
D
--
R
P
Q
H
E
R
T
K
A
------------
89
PsiBlast_CBE
35.59
31%
-93
- C1 -
3C4J
4
?
B:
[39-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
N
LN
K
-
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-----
I
T
L
A
--
P
M
K
V
----
R
K
W
P
R
E
K
A
E
A
K
A
---
M
E
L
L
D
--
K
--
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-
D
--
R
P
Q
H
E
R
T
K
A
------------
98
PsiBlast_CBE
35.57
31%
-94
- C1 -
2OLK
1
?
C:
[39-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
N
LN
K
-
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-----
I
T
L
A
--
P
M
K
V
----
R
K
W
P
R
E
K
A
E
A
K
A
---
M
E
L
L
D
--
K
--
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-
D
--
R
P
Q
H
E
R
T
K
A
------------
99
PsiBlast_CBE
35.11
31%
-93
- C1 -
2OLK
2
?
B:
[39-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
N
LN
K
-
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-----
I
T
L
A
--
P
M
K
V
----
R
K
W
P
R
E
K
A
E
A
K
A
---
M
E
L
L
D
--
K
--
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-
D
--
R
P
Q
H
E
R
T
K
A
------------
90
PsiBlast_CBE
34.68
31%
-87
- C1 -
3C4J
3
?
A:
[39-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
N
L
N
K
-
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-----
I
T
L
A
--
P
M
K
V
----
R
K
W
P
R
E
K
A
E
A
K
A
---
M
E
L
L
D
--
K
--
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-
D
--
R
P
Q
H
E
R
T
K
A
------------
88
PsiBlast_CBE
34.55
35%
-85
- C1 -
4U00
3
?
A:
[19-226]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
---
E
G
E
V
V
V
D
G
L
S
V
K
--
D
D
R
A
L
--
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
-
G
I
L
---
D
------------
Q
A
R
--
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
-
G
---
G
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
-------------------------
101
PsiBlast_CBE
33.79
31%
-91
- C1 -
2OLJ
3
?
B:
[39-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
N
LN
K
-
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-----
I
T
L
A
--
P
M
K
V
----
R
K
W
P
R
E
K
A
E
A
K
A
---
M
E
L
L
D
--
K
--
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-
D
--
R
P
Q
H
E
R
T
K
A
------------
91
PsiBlast_CBE
33.47
31%
-92
- C1 -
2Q0H
4
?
B:
[39-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
K
--
A
K
D
T
N
L
N
K
-
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-----
I
T
L
A
--
P
M
K
V
----
R
K
W
P
R
E
K
A
E
A
K
A
---
M
E
L
L
D
--
K
--
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
---
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-
D
--
R
P
Q
H
E
R
T
K
A
------------