@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1293: (2016-04-30 )
MNELLHLAPNVWPRNTTRDEVGVVCIAGIPLTQLAQEYGTPLFVIDEDDFRSRCRETAAAFGSGANVHYAAKAFLCSEVARWISEEGLCLDVCTGGELAVALHASFPPERITLHGNNKSVSELTAAVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDVLVRLTVGVEAHTHEFISTAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVDGFELAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPIAELAAKLGTIVSDESTAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDVDVSATAHRRYVSVDGGMSDNIRTALYGAQYDVRLVSRVSDAPPVPARLVGKHCESGDIIVRDTWVPDDIRPGDLVAVAATGAYCYSLSSRYNMVGRPAVVAVHAGNARLVLRRETVDDLLSLEVR
Atome Classification :
(20 SA)
.........10.....-...20........30........40........50........60-------.-.-------...-.--..70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270....-...280.......290.......300.......310.......320.......330.......340.......350..--.....360-.......370.......380.......390........400.......410.......420....-...430.........440.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
E
L
L
HLAPNVWPRNT-TRDEV
G
V
V
C
IAGI
P
L
T
Q
L
A
Q
E
YGT
P
L
F
V
ID
E
D
D
F
R
S
R
C
R
E
T
A
A
AF-------G-S-------GA
N
-
V
--
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
SEEG
L
C
L
D
V
CTGG
E
L
A
V
A
L
HASFPP
E
R
I
T
L
HGNNK
S
V
S
E
L
T
A
A
V
K
AGV
G
H
I
V
V
D
S
M
T
E
I
E
R
L
D
A
IAGEA
G
I
V
Q
D
V
L
V
R
L
TVGVE
A
H
T
H
E
F
I
S
T
AHEDQKF
G
L
SVAS
G
A
A
M
A
A
V
R
R
V
F
ATD
H
L
R
L
V
G
L
H
S
HIG
S
Q
I
FDVD
G
F
E
L
A
A
H
R
V
I
G
L
L
R
D
V
V
G
EFGPEKT
A
Q
I
A
T
V
DLGGGLGISYLPSDDPP
P
I
A
E
L
A
-
A
K
L
G
T
IVSDESTAVGLPT
P
K
L
V
VEPGRAIAGP
G
T
I
T
L
Y
E
VG
T
V
K
D
V
DVSATA
H
R
R
Y
V
S
VDGGMSD
N
I
R
T
A
L
YGAQ
Y
D
V
--
R
L
V
S
R
VSD-APPV
P
A
R
L
V
G
KHCESG
D
I
I
V
RDTWVPDD-IRPG
D
L
V
A
V
A
AT
G
A
Y
C
Y
SLSSRYNMVGR
P
A
V
V
A
V
HA-G
N
A
R
--
L
V
L
RRE
T
V
D
D
L
LSLEVR
21
PsiBlast_CBE
99.33
100%
-120
- C1 -
1HKV
4
DCDA_MYCTU
B:
[2-447]
-
N
E
L
L
H
L
A
P
N
V
W
P
R
N
T
-
T
R
D
E
V
G
V
V
C
I
A
G
I
P
L
T
Q
L
A
Q
E
Y
G
T
P
L
F
V
I
D
E
D
D
F
R
S
R
C
R
E
T
A
A
A
F
-------
G
-
S
-------
G
A
N
-
V
--
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
S
E
E
G
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
S
F
P
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
A
V
K
A
G
V
G
H
I
V
V
D
S
M
T
E
I
E
R
L
D
A
I
A
G
E
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
A
V
R
R
V
F
A
T
D
H
L
R
L
V
G
L
H
S
H
I
G
S
Q
I
F
D
V
D
G
F
E
L
A
A
H
R
V
I
G
L
L
R
D
V
V
G
E
F
G
P
E
K
T
A
Q
I
A
T
V
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
P
P
P
I
A
E
L
A
-
A
K
L
G
T
I
V
S
D
E
S
T
A
V
G
L
P
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
K
D
V
D
V
S
A
T
A
H
R
R
Y
V
S
V
D
G
G
M
S
D
N
I
R
T
A
L
Y
G
A
Q
Y
D
V
--
R
L
V
S
R
V
S
D
-
A
P
P
V
P
A
R
L
V
G
K
H
C
E
S
G
D
I
I
V
R
D
T
W
V
P
D
D
-
I
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
Y
S
L
S
S
R
Y
N
M
V
G
R
P
A
V
V
A
V
H
A
-
G
N
A
R
--
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
V
R
22
PsiBlast_CBE
99.28
99%
-121
- C1 -
2O0T
1
DCDA_MYCTU
B:
[4-449]
-
N
E
L
L
H
L
A
P
N
V
W
P
R
N
T
-
T
R
D
E
V
G
V
V
C
I
A
G
I
P
L
T
Q
L
A
Q
E
Y
G
T
P
L
F
V
I
D
E
D
D
F
R
S
R
C
R
E
T
A
A
A
F
-------
G
-
S
-------
G
A
N
-
V
--
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
S
E
E
G
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
S
F
P
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
A
V
K
A
G
V
G
H
I
V
V
D
S
M
T
E
I
E
R
L
D
A
I
A
G
E
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
A
V
R
R
V
F
A
T
D
H
L
R
L
V
G
L
H
S
H
I
G
S
Q
I
F
D
V
D
G
F
E
L
A
A
H
R
V
I
G
L
L
R
D
V
V
G
E
F
G
P
E
K
T
A
Q
I
A
T
V
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
P
P
P
I
A
E
L
A
-
A
K
L
G
T
I
V
S
D
E
S
T
A
V
G
L
P
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
K
D
V
D
V
S
A
T
A
H
R
R
Y
V
S
V
D
G
G
M
S
D
N
I
R
T
A
L
Y
G
A
Q
Y
D
V
--
R
L
V
S
R
V
S
D
-
A
P
P
V
P
A
R
L
V
G
K
H
C
E
S
G
D
I
I
V
R
D
T
W
V
P
D
D
-
I
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
Y
S
L
S
S
R
Y
N
M
V
G
R
P
A
V
V
A
V
H
A
-
G
N
A
R
--
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
V
R
28
HHSearch
99.03
100%
-118
- C1 -
2O0T
1
DCDA_MYCTU
A:
[4-448]
-
N
E
L
L
H
L
A
P
N
V
W
P
R
N
T
-
T
R
D
E
V
G
V
V
C
I
A
G
I
P
L
T
Q
L
A
Q
E
Y
G
T
P
L
F
V
I
D
E
D
D
F
R
S
R
C
R
E
T
A
A
A
F
-------
G
-
S
-------
G
A
N
-
V
--
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
S
E
E
G
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
S
F
P
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
A
V
K
A
G
V
G
H
I
V
V
D
S
M
T
E
I
E
R
L
D
A
I
A
G
E
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
A
V
R
R
V
F
A
T
D
H
L
R
L
V
G
L
H
S
H
I
G
S
Q
I
F
D
V
D
G
F
E
L
A
A
H
R
V
I
G
L
L
R
D
V
V
G
E
F
G
P
E
K
T
A
Q
I
A
T
V
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
P
P
P
I
A
E
L
A
-
A
K
L
G
T
I
V
S
D
E
S
T
A
V
G
L
P
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
K
D
V
D
V
S
A
T
A
H
R
R
Y
V
S
V
D
G
G
M
S
D
N
I
R
T
A
L
Y
G
A
Q
Y
D
V
--
R
L
V
S
R
V
S
D
-
A
P
P
V
P
A
R
L
V
G
K
H
C
E
S
G
D
I
I
V
R
D
T
W
V
P
-
D
D
I
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
Y
S
L
S
S
R
Y
N
M
V
G
R
P
A
V
V
A
V
H
A
-
G
N
A
R
--
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
V
-
2
PsiBlast_PDB
98.78
99%
-117
- C1 -
2O0T
1
DCDA_MYCTU
A:
[4-449]
-
N
E
L
L
H
L
A
P
N
V
W
P
R
N
T
-
T
R
D
E
V
G
V
V
C
I
A
G
I
P
L
T
Q
L
A
Q
E
Y
G
T
P
L
F
V
I
D
E
D
D
F
R
S
R
C
R
E
T
A
A
A
F
-------
G
-
S
-------
G
A
N
-
V
--
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
S
E
E
G
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
S
F
P
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
A
V
K
A
G
V
G
H
I
V
V
D
S
M
T
E
I
E
R
L
D
A
I
A
G
E
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
A
V
R
R
V
F
A
T
D
H
L
R
L
V
G
L
H
S
H
I
G
S
Q
I
F
D
V
D
G
F
E
L
A
A
H
R
V
I
G
L
L
R
D
V
V
G
E
F
G
P
E
K
T
A
Q
I
A
T
V
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
P
P
P
I
A
E
L
A
-
A
K
L
G
T
I
V
S
D
E
S
T
A
V
G
L
P
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
K
D
V
D
V
S
A
T
A
H
R
R
Y
V
S
V
D
G
G
M
S
D
N
I
R
T
A
L
Y
G
A
Q
Y
D
V
--
R
L
V
S
R
V
S
D
-
A
P
P
V
P
A
R
L
V
G
K
H
C
E
S
G
D
I
I
V
R
D
T
W
V
P
D
D
-
I
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
Y
S
L
S
S
R
Y
N
M
V
G
R
P
A
V
V
A
V
H
A
-
G
N
A
R
--
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
V
R
3
PsiBlast_PDB
98.76
99%
-119
- C1 -
1HKW
1
DCDA_MYCTU
A:
[2-447]
-
N
E
L
L
H
L
A
P
N
V
W
P
R
N
T
-
T
R
D
E
V
G
V
V
C
I
A
G
I
P
L
T
Q
L
A
Q
E
Y
G
T
P
L
F
V
I
D
E
D
D
F
R
S
R
C
R
E
T
A
A
A
F
-------
G
-
S
-------
G
A
N
-
V
--
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
S
E
E
G
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
S
F
P
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
A
V
K
A
G
V
G
H
I
V
V
D
S
M
T
E
I
E
R
L
D
A
I
A
G
E
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
A
V
R
R
V
F
A
T
D
H
L
R
L
V
G
L
H
S
H
I
G
S
Q
I
F
D
V
D
G
F
E
L
A
A
H
R
V
I
G
L
L
R
D
V
V
G
E
F
G
P
E
K
T
A
Q
I
A
T
V
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
P
P
P
I
A
E
L
A
-
A
K
L
G
T
I
V
S
D
E
S
T
A
V
G
L
P
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
K
D
V
D
V
S
A
T
A
H
R
R
Y
V
S
V
D
G
G
M
S
D
N
I
R
T
A
L
Y
G
A
Q
Y
D
V
--
R
L
V
S
R
V
S
D
-
A
P
P
V
P
A
R
L
V
G
K
H
C
E
S
G
D
I
I
V
R
D
T
W
V
P
D
D
-
I
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
Y
S
L
S
S
R
Y
N
M
V
G
R
P
A
V
V
A
V
H
A
-
G
N
A
R
--
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
V
R
1
PsiBlast_PDB
98.60
100%
-119
- C1 -
1HKV
4
DCDA_MYCTU
A:
[2-447]
-
N
E
L
L
H
L
A
P
N
V
W
P
R
N
T
-
T
R
D
E
V
G
V
V
C
I
A
G
I
P
L
T
Q
L
A
Q
E
Y
G
T
P
L
F
V
I
D
E
D
D
F
R
S
R
C
R
E
T
A
A
A
F
-------
G
-
S
-------
G
A
N
-
V
--
H
Y
A
A
K
A
F
L
C
S
E
V
A
R
W
I
S
E
E
G
L
C
L
D
V
C
T
G
G
E
L
A
V
A
L
H
A
S
F
P
P
E
R
I
T
L
H
G
N
N
K
S
V
S
E
L
T
A
A
V
K
A
G
V
G
H
I
V
V
D
S
M
T
E
I
E
R
L
D
A
I
A
G
E
A
G
I
V
Q
D
V
L
V
R
L
T
V
G
V
E
A
H
T
H
E
F
I
S
T
A
H
E
D
Q
K
F
G
L
S
V
A
S
G
A
A
M
A
A
V
R
R
V
F
A
T
D
H
L
R
L
V
G
L
H
S
H
I
G
S
Q
I
F
D
V
D
G
F
E
L
A
A
H
R
V
I
G
L
L
R
D
V
V
G
E
F
G
P
E
K
T
A
Q
I
A
T
V
D
L
G
G
G
L
G
I
S
Y
L
P
S
D
D
P
P
P
I
A
E
L
A
-
A
K
L
G
T
I
V
S
D
E
S
T
A
V
G
L
P
T
P
K
L
V
V
E
P
G
R
A
I
A
G
P
G
T
I
T
L
Y
E
V
G
T
V
K
D
V
D
V
S
A
T
A
H
R
R
Y
V
S
V
D
G
G
M
S
D
N
I
R
T
A
L
Y
G
A
Q
Y
D
V
--
R
L
V
S
R
V
S
D
-
A
P
P
V
P
A
R
L
V
G
K
H
C
E
S
G
D
I
I
V
R
D
T
W
V
P
D
D
-
I
R
P
G
D
L
V
A
V
A
A
T
G
A
Y
C
Y
S
L
S
S
R
Y
N
M
V
G
R
P
A
V
V
A
V
H
A
-
G
N
A
R
--
L
V
L
R
R
E
T
V
D
D
L
L
S
L
E
V
R
31
HHSearch
76.47
31%
-111
- C1 -
1TWI
3
DCDA_METJA
A:
[9-428]
-------------------
I
K
D
G
R
F
F
I
D
G
Y
D
A
I
E
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
-------
K
-
R
W
E
E
E
TG
K
E
F
I
-
V
--
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
S
K
K
I
V
F
N
G
N
C
K
T
K
E
E
I
I
M
G
I
E
A
N
I
R
A
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
L
D
V
E
S
G
I
A
M
K
A
I
K
M
A
L
E
M
E
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
E
E
T
R
K
V
M
D
F
V
V
E
L
K
E
-----
E
G
I
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
K
D
K
Q
I
P
T
Q
K
D
L
A
-
D
A
I
I
N
T
M
L
K
Y
K
D
--
K
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
E
T
P
-----
V
T
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
I
--
I
N
-
C
K
-
V
K
-
N
E
K
E
V
V
S
I
A
G
G
L
C
E
S
S
D
V
F
G
R
D
R
E
L
D
-
K
-
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
A
R
G
R
P
R
M
V
L
T
S
K
-
K
G
V
F
--
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
-
5
PsiBlast_PDB
74.57
31%
-111
- C1 -
1TWI
3
DCDA_METJA
A:
[12-428]
----------------------
G
R
F
F
I
D
G
Y
D
A
I
E
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
K
R
W
E
E
E
T
G
-
K
-------
E
F
I
-
V
--
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
S
K
K
I
V
F
N
G
N
C
K
T
K
E
E
I
I
M
G
I
E
A
N
I
R
A
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
L
D
V
E
S
G
I
A
M
K
A
I
K
M
A
L
E
M
E
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
E
E
T
R
K
V
M
----
D
F
V
V
E
L
-
K
E
E
G
I
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
K
D
K
Q
I
P
T
Q
K
D
L
A
D
A
I
I
N
T
M
L
K
Y
K
D
K
---
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
E
T
P
V
T
-----
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
I
---
I
N
C
K
V
K
N
-
E
K
E
V
-
V
S
I
A
G
G
L
C
E
S
S
D
V
F
G
R
D
R
E
L
-
D
K
-
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
A
R
G
R
P
R
M
V
L
T
S
K
-
K
G
V
F
--
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
-
25
PsiBlast_CBE
74.33
31%
-111
- C1 -
1TWI
3
DCDA_METJA
B:
[12-428]
----------------------
G
R
F
F
I
D
G
Y
D
A
I
E
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
KRWEEET
G
-
K
-------
E
F
I
-
V
--
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
S
K
K
I
V
F
N
G
N
C
K
T
K
E
E
I
I
M
G
I
E
A
N
I
R
A
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
L
D
V
E
S
G
I
A
M
K
A
I
K
M
A
L
E
M
E
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
E
E
T
R
K
V
M
----
D
F
V
V
E
L
-
K
E
E
G
I
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
K
D
K
Q
I
P
T
Q
K
D
L
A
D
A
I
I
N
T
M
L
K
Y
K
D
K
---
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
E
T
P
V
T
-----
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
I
---
I
N
C
K
V
K
N
-
E
K
E
V
-
V
S
I
A
G
G
L
C
E
S
S
D
V
F
G
R
D
R
E
L
-
D
K
-
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
A
R
G
R
P
R
M
V
L
T
S
K
-
K
G
V
F
--
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
-
23
PsiBlast_CBE
74.17
31%
-110
- C1 -
1TWI
3
DCDA_METJA
D:
[12-428]
----------------------
G
R
F
F
I
D
G
Y
D
A
I
E
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
KRWEEET
G
-
K
-------
E
F
I
-
V
--
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
S
K
K
I
V
F
N
G
N
C
K
T
K
E
E
I
I
M
G
I
E
A
N
I
R
A
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
L
D
V
E
S
G
I
A
M
K
A
I
K
M
A
L
E
M
E
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
E
E
T
R
K
V
M
----
D
F
V
V
E
L
-
K
E
E
G
I
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
K
D
K
Q
I
P
T
Q
K
D
L
A
D
A
I
I
N
T
M
L
K
Y
K
D
K
---
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
E
T
P
V
T
-----
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
I
---
I
N
C
K
V
K
N
-
E
K
E
V
-
V
S
I
A
G
G
L
C
E
S
S
D
V
F
G
R
D
R
E
L
-
D
K
-
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
A
R
G
R
P
R
M
V
L
T
S
K
-
K
G
V
F
--
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
-
46
HHSearch
74.07
34%
-121
- C1 -
2P3E
-
DCDA_AQUAE
A:
[13-416]
-------------------
Y
R
D
G
E
L
F
I
E
G
V
S
L
K
E
L
A
Q
T
F
G
T
P
L
Y
V
Y
S
S
N
F
I
K
E
R
F
E
A
Y
R
K
A
F
---------
P
-------
D
A
L
-
I
--
C
Y
A
V
K
A
N
F
N
P
H
L
V
K
L
L
G
E
L
G
A
G
A
D
I
V
S
G
G
E
L
Y
L
A
K
K
A
G
I
P
P
E
R
I
V
Y
A
G
V
G
K
T
E
K
E
L
T
D
A
V
D
S
E
I
L
M
F
N
V
E
S
R
Q
E
L
D
V
L
N
E
I
A
G
K
L
G
K
K
A
R
I
A
I
R
V
N
P
----------------
S
K
F
G
V
D
I
R
E
A
Q
--
K
E
Y
E
Y
A
S
K
L
E
N
L
E
I
V
G
I
H
C
H
I
G
S
Q
I
L
D
I
S
P
Y
R
E
A
V
E
K
V
V
S
L
Y
E
S
L
T
Q
-----
K
G
F
D
I
K
Y
L
D
I
G
G
G
L
G
I
K
Y
K
P
E
D
K
E
P
A
P
Q
D
L
A
-
D
L
L
K
D
L
L
---------
V
K
A
K
I
I
L
E
P
G
R
S
I
M
G
N
A
G
I
L
I
T
Q
V
Q
F
L
K
D
K
G
-----
S
K
H
F
I
I
V
D
A
G
M
N
D
L
I
R
P
S
I
Y
N
A
Y
H
H
I
--
I
P
V
E
T
-
K
E
----
V
V
A
D
I
V
G
P
I
C
E
T
G
D
F
L
A
L
D
R
E
I
E
-
E
-
V
Q
R
G
E
Y
L
A
V
L
S
A
G
A
Y
G
F
A
M
S
S
H
Y
N
M
R
P
R
A
A
E
V
L
V
E
N
-
G
S
V
K
--
L
I
R
K
R
E
N
Y
D
Y
I
V
E
P
---
24
PsiBlast_CBE
73.91
31%
-111
- C1 -
1TWI
3
DCDA_METJA
C:
[12-428]
----------------------
G
R
F
F
I
D
G
Y
D
A
I
E
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
KRWEEET
G
-
K
-------
E
F
I
-
V
--
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
S
K
K
I
V
F
N
G
N
C
K
T
K
E
E
I
I
M
G
I
E
A
N
I
R
A
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
L
D
V
E
S
G
I
A
M
K
A
I
K
M
A
L
E
M
E
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
E
E
T
R
K
V
M
----
D
F
V
V
E
L
-
K
E
E
G
I
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
K
D
K
Q
I
P
T
Q
K
D
L
A
D
A
I
I
N
T
M
L
K
Y
K
D
K
---
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
E
T
P
V
T
-----
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
I
---
I
N
C
K
V
K
N
-
E
K
E
V
-
V
S
I
A
G
G
L
C
E
S
S
D
V
F
G
R
D
R
E
L
-
D
K
-
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
A
R
G
R
P
R
M
V
L
T
S
K
-
K
G
V
F
--
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
-
6
PsiBlast_PDB
73.89
31%
-111
- C1 -
1TUF
2
DCDA_METJA
A:
[12-428]
----------------------
G
R
F
F
I
D
G
Y
D
A
I
E
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
KRWEEET
G
-
K
-------
E
F
I
-
V
--
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
S
K
K
I
V
F
N
G
N
C
K
T
K
E
E
I
I
M
G
I
E
A
N
I
R
A
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
L
D
V
E
S
G
I
A
M
K
A
I
K
M
A
L
E
M
E
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
E
E
T
R
K
V
M
----
D
F
V
V
E
L
-
K
E
E
G
I
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
K
D
K
Q
I
P
T
Q
K
D
L
A
D
A
I
I
N
T
M
L
K
Y
K
D
K
---
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
E
T
P
V
T
-----
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
I
---
I
N
C
K
V
K
N
-
E
K
E
V
-
V
S
I
A
G
G
L
C
E
S
S
D
V
F
G
R
D
R
E
L
-
D
K
-
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
A
R
G
R
P
R
M
V
L
T
S
K
-
K
G
V
F
--
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
-
44
HHSearch
72.70
28%
-108
- C1 -
2QGH
2
DCDA_HELPX
A:
[23-419]
------------------------------
N
Y
E
E
L
F
Q
T
H
K
T
P
F
Y
L
Y
D
F
D
K
I
K
Q
A
F
L
N
Y
K
E
A
F
-------
K
-
G
R
------
K
S
L
-
I
--
C
Y
A
L
K
A
N
S
N
L
S
I
L
S
L
L
A
H
L
E
S
G
A
D
C
V
S
I
G
E
I
Q
R
A
L
K
A
G
I
K
P
Y
R
I
V
F
S
G
V
G
K
S
A
F
E
I
E
Q
A
L
K
L
N
I
L
F
L
N
V
E
S
F
M
E
L
K
T
I
E
T
I
A
Q
S
L
G
I
K
A
R
I
S
I
R
I
N
P
N
I
D
A
K
T
H
P
Y
I
S
T
G
L
K
E
N
K
F
G
V
G
E
K
E
A
L
--
E
M
F
L
W
A
K
K
S
A
F
L
E
P
V
S
V
H
F
H
I
G
S
Q
L
L
D
L
E
P
I
I
E
A
S
Q
K
V
A
K
I
A
K
S
L
I
A
-----
L
G
I
D
L
R
F
F
D
V
G
G
G
I
G
V
S
Y
E
N
E
-
E
T
I
K
L
Y
D
Y
A
-
Q
G
I
L
N
A
L
Q
G
-------
L
D
L
T
I
I
C
E
P
G
R
S
I
V
A
E
S
G
E
L
I
T
Q
V
L
Y
E
K
K
-------
N
K
R
F
V
I
V
D
A
G
M
N
D
F
L
R
P
S
L
Y
H
A
K
H
A
I
--
R
V
I
T
P
S
----
E
I
S
P
C
D
V
V
G
P
V
C
E
S
S
D
T
F
L
K
D
A
H
L
P
-
E
-
L
E
P
G
D
K
I
A
I
E
K
V
G
A
Y
G
S
S
M
A
S
Q
Y
N
S
R
P
K
L
L
E
L
A
L
E
D
--
K
I
R
--
V
I
R
K
R
E
A
L
E
D
L
W
R
L
E
E
-
4
PsiBlast_PDB
71.61
32%
-111
- C1 -
2P3E
-
DCDA_AQUAE
A:
[2-411]
-----
E
L
L
K
E
Y
N
P
Y
L
E
-
Y
R
D
--
G
E
L
F
I
E
G
V
S
L
K
E
L
A
Q
T
F
G
T
P
L
Y
V
Y
S
S
N
F
I
K
E
R
F
E
A
Y
R
K
A
F
---------
P
-------
D
A
L
-
I
--
C
Y
A
V
K
A
N
F
N
P
H
L
V
K
L
L
G
E
L
G
A
G
A
D
I
V
S
G
G
E
L
Y
L
A
K
K
A
G
I
P
P
E
R
I
V
Y
A
G
V
G
K
T
E
K
E
L
T
D
A
V
D
S
E
I
L
M
F
N
V
E
S
R
Q
E
L
D
V
L
N
E
I
A
G
K
L
G
K
K
A
R
I
A
I
R
V
N
P
----------------
S
K
F
G
V
D
I
R
E
--
A
Q
K
E
Y
E
Y
A
S
K
L
E
N
L
E
I
V
G
I
H
C
H
I
G
S
Q
I
L
D
I
S
P
Y
R
E
A
V
E
K
V
V
S
L
Y
E
S
L
T
-----
Q
K
G
F
D
I
K
Y
L
D
I
G
G
G
L
G
I
K
Y
K
P
E
D
K
E
P
--
A
P
Q
D
-
L
A
D
L
L
K
D
L
L
--
V
K
A
-----
K
I
I
L
E
P
G
R
S
I
M
G
N
A
G
I
L
I
T
Q
V
Q
F
L
K
D
-----
K
G
S
K
H
F
I
I
V
D
A
G
M
N
D
L
I
R
P
S
I
Y
N
A
Y
H
H
I
--
I
P
V
E
-
T
K
E
----
V
V
A
D
I
V
G
P
I
C
E
T
G
D
F
L
A
L
D
R
E
I
-
E
E
-
V
Q
R
G
E
Y
L
A
V
L
S
A
G
A
Y
G
F
A
M
S
S
H
Y
N
M
R
P
R
A
A
E
V
L
V
E
N
-
G
S
V
K
--
L
I
R
K
R
E
N
Y
D
--------
39
HHSearch
70.86
35%
-112
- C1 -
3VAB
4
?
A:
[29-437]
--------------------
R
N
G
V
L
H
A
E
N
V
S
L
P
E
I
A
K
A
V
G
T
P
F
Y
V
Y
S
R
A
T
I
E
R
H
F
R
V
F
H
D
A
F
-------
A
D
M
-------
D
T
L
-
V
--
T
Y
A
L
K
A
N
S
N
Q
A
V
L
T
A
L
A
K
L
G
A
G
A
D
T
V
S
Q
G
E
I
R
R
A
L
A
A
G
I
P
A
N
R
I
V
F
S
G
V
G
K
T
P
R
E
M
D
F
A
L
E
A
G
I
Y
C
F
N
V
E
S
E
P
E
L
E
I
L
S
A
R
A
V
A
A
G
K
V
A
P
V
S
L
R
I
N
P
D
V
D
A
K
T
H
A
K
I
---
K
S
E
N
K
F
G
I
P
R
D
K
A
R
--
A
A
Y
A
R
A
A
S
L
P
G
L
N
V
V
G
I
D
M
H
I
G
S
Q
I
I
D
L
E
P
F
D
N
A
F
A
L
M
A
E
L
V
K
E
L
Q
A
-----
D
G
H
N
I
R
H
V
D
V
G
G
G
L
G
I
P
Y
R
T
P
--
P
P
P
P
V
A
Y
A
-
Q
I
V
A
K
H
I
K
P
-------
L
G
L
K
T
V
F
E
P
G
R
L
I
V
G
N
A
G
L
L
V
T
E
V
I
F
V
K
E
G
D
-----
A
K
N
F
V
I
V
D
A
A
M
N
D
L
I
R
P
T
L
Y
D
A
F
H
D
I
R
P
V
I
M
P
N
-
D
N
-
A
P
R
I
R
A
D
F
V
G
P
V
C
E
T
G
D
Y
L
G
L
D
R
E
V
A
-
K
-
P
A
P
G
D
L
I
A
I
C
T
T
G
A
Y
G
A
V
L
S
S
T
Y
N
S
R
L
L
I
P
E
V
L
G
D
G
-
E
R
Y
H
--
V
V
R
P
R
R
T
Y
E
E
L
L
A
L
D
--
30
HHSearch
70.70
33%
-105
- C1 -
2YXX
1
DCDA_THEMA
A:
[4-385]
-------------------------------
L
R
K
V
A
E
I
H
G
T
P
T
Y
V
Y
F
E
E
T
L
R
K
R
S
R
L
V
K
E
V
F
-------
E
G
V
-------
N
L
L
-
P
--
T
F
A
V
K
A
N
N
N
P
V
L
L
K
I
L
R
E
E
G
F
G
M
D
V
V
T
K
G
E
L
L
A
A
K
L
A
G
V
P
S
H
T
V
V
W
N
G
N
G
K
S
R
D
Q
M
E
H
F
L
R
E
D
V
R
I
V
N
V
D
S
F
E
E
M
E
I
W
R
E
L
N
P
---
E
G
V
E
Y
F
I
R
V
N
P
E
V
D
A
K
T
H
P
H
I
S
T
G
L
K
K
H
K
F
G
I
P
L
E
D
L
D
--
S
F
M
-
E
R
--
F
R
S
M
N
I
R
G
L
H
V
H
I
G
S
Q
I
T
R
V
E
P
F
V
E
A
F
S
K
V
V
R
A
S
E
----
R
----
Y
G
--
F
E
E
I
N
I
G
G
G
W
G
I
N
Y
S
G
--
E
E
L
D
L
S
S
Y
R
-
E
K
V
V
P
D
L
K
R
--------
F
K
R
V
I
V
E
I
G
R
Y
I
V
A
P
S
G
Y
L
L
L
R
V
V
L
V
K
R
R
H
-----
N
K
A
F
V
V
V
D
G
G
M
N
V
L
I
R
P
A
L
Y
S
A
Y
H
R
I
--
F
V
L
G
K
--
Q
-
G
K
E
M
R
A
D
V
V
G
P
L
C
E
S
G
D
V
I
A
Y
D
R
E
L
P
-
E
-
V
E
P
G
D
I
I
A
V
E
N
A
G
A
Y
G
Y
T
M
S
N
N
Y
N
S
T
T
R
P
A
E
V
L
V
R
E
N
G
R
I
S
--
L
I
R
R
R
E
T
E
M
D
I
F
K
D
V
V
-
10
PsiBlast_PDB
70.07
34%
-108
- C1 -
3VAB
4
?
A:
[31-437]
----------------------
G
V
L
H
A
E
N
V
S
L
P
E
I
A
K
A
V
G
T
P
F
Y
V
Y
S
R
A
T
I
E
R
H
F
R
V
F
H
D
A
F
-------
A
-
D
-------
M
D
T
L
V
--
T
Y
A
L
K
A
N
S
N
Q
A
V
L
T
A
L
A
K
L
G
A
G
A
D
T
V
S
Q
G
E
I
R
R
A
L
A
A
G
I
P
A
N
R
I
V
F
S
G
V
G
K
T
P
R
E
M
D
F
A
L
E
A
G
I
Y
C
F
N
V
E
S
E
P
E
L
E
I
L
S
A
R
A
V
A
A
G
K
V
A
P
V
S
L
R
I
N
P
D
V
D
A
K
T
H
A
K
I
---
K
S
E
N
K
F
G
--
I
P
R
D
K
A
R
A
A
Y
A
R
A
A
S
L
P
G
L
N
V
V
G
I
D
M
H
I
G
S
Q
I
I
D
L
E
P
F
D
N
A
----
F
A
L
M
A
E
L
V
K
E
L
Q
A
D
G
H
-
N
I
R
H
V
D
V
G
G
G
L
G
I
P
Y
R
T
P
------
P
P
P
P
-
V
A
Y
A
Q
I
V
A
K
H
I
K
P
L
G
L
---
K
T
V
F
E
P
G
R
L
I
V
G
N
A
G
L
L
V
T
E
V
I
F
V
K
E
G
D
A
-----
K
N
F
V
I
V
D
A
A
M
N
D
L
I
R
P
T
L
Y
D
A
F
H
D
I
--
R
P
V
I
M
P
N
D
N
A
P
R
I
R
A
D
F
V
G
P
V
C
E
T
G
D
Y
L
G
L
D
R
E
V
A
K
P
-
A
-
P
G
D
L
I
A
I
C
T
T
G
A
Y
G
A
V
L
S
S
T
Y
N
--
S
R
L
L
I
P
E
V
L
G
-
D
G
E
R
YH
V
V
R
P
R
R
T
Y
E
E
L
L
A
L
D
--
11
PsiBlast_PDB
69.72
31%
-105
- C1 -
2YXX
1
DCDA_THEMA
A:
[4-382]
-------------------------------
L
R
K
V
A
E
I
H
G
T
P
T
Y
V
Y
F
E
E
T
L
R
K
R
S
R
L
V
K
E
V
F
---------
E
-------
G
V
N
-
L
L
P
T
F
A
V
K
A
N
N
N
P
V
L
L
K
I
L
R
E
E
G
F
G
M
D
V
V
T
K
G
E
L
L
A
A
K
L
A
G
V
P
S
H
T
V
V
W
N
G
N
G
K
S
R
D
Q
M
E
H
F
L
R
E
D
V
R
I
V
N
V
D
S
F
E
E
M
E
I
W
R
E
L
N
P
E
G
---
V
E
Y
F
I
R
V
N
P
E
V
D
A
K
T
H
P
H
I
S
T
G
L
K
K
H
K
F
G
I
P
L
E
D
---
L
D
S
F
M
E
R
F
R
S
M
N
I
R
--
G
L
H
V
H
I
G
S
Q
I
T
R
V
E
P
F
V
E
A
F
S
K
V
V
----
R
A
S
E
R
Y
G
F
E
E
------
I
N
I
G
G
G
W
G
I
N
Y
S
G
E
E
-----
L
D
L
S
-
S
Y
R
E
K
V
V
P
D
L
K
R
F
-----
K
R
V
I
V
E
I
G
R
Y
I
V
A
P
S
G
Y
L
L
L
R
V
V
L
V
K
-----
R
R
H
N
K
A
F
V
V
V
D
G
G
M
N
V
L
I
R
P
A
L
Y
S
A
Y
H
R
I
--
F
V
L
G
K
--
Q
-
G
K
E
M
R
A
D
V
V
G
P
L
C
E
S
G
D
V
I
A
Y
D
R
E
L
P
E
--
V
E
P
G
D
I
I
A
V
E
N
A
G
A
Y
G
Y
T
M
S
N
N
Y
N
S
T
T
R
P
A
E
V
L
V
R
E
N
G
R
I
S
--
L
I
R
R
R
E
T
E
M
D
I
F
K
----
42
HHSearch
69.70
31%
-112
- C1 -
3N2B
1
DCDA_VIBCH
A:
[21-437]
---------
Q
S
N
A
M
D
Y
F
N
Y
Q
E
D
G
Q
L
W
A
E
Q
V
P
L
A
D
L
A
N
Q
Y
G
T
P
L
Y
V
Y
S
R
A
T
L
E
R
H
W
H
A
F
D
K
S
V
-------
G
-
D
Y
------
P
H
L
-
I
--
C
Y
A
V
K
A
N
S
N
L
G
V
L
N
T
L
A
R
L
G
S
G
F
D
I
V
S
V
G
E
L
E
R
V
L
A
A
G
G
D
P
S
K
V
V
F
S
G
V
G
K
T
E
A
E
M
K
R
A
L
Q
L
K
I
K
C
F
N
V
E
S
E
P
E
L
Q
R
L
N
K
V
A
G
E
L
G
V
K
A
P
I
S
L
R
I
N
P
D
V
D
A
K
T
H
P
Y
I
S
T
G
L
R
D
N
K
F
G
I
T
F
D
R
A
A
--
Q
V
Y
R
L
A
H
S
L
P
N
L
D
V
H
G
I
D
C
H
I
G
S
Q
L
T
A
L
A
P
F
I
D
A
T
D
R
L
L
A
L
I
D
S
L
K
A
-----
E
G
I
H
I
R
H
L
D
V
G
G
G
L
G
V
V
Y
------
P
Q
P
S
E
Y
A
-
K
A
L
L
D
R
L
E
R
------
H
R
D
L
E
L
I
F
E
P
G
R
A
I
A
A
N
A
G
V
L
V
T
K
V
E
F
L
K
H
T
-------
K
N
F
A
I
I
D
A
A
M
N
D
L
I
R
-------
Q
D
I
--
I
P
L
R
P
-
R
Q
-
G
E
A
Q
T
Y
D
L
V
G
P
V
C
E
T
S
D
F
L
G
K
D
R
D
L
V
---
L
Q
E
G
D
L
L
A
V
R
S
S
G
A
Y
G
F
T
M
S
S
N
Y
N
T
R
P
R
V
A
E
V
M
V
D
G
-
N
K
T
Y
--
L
V
R
Q
R
E
E
L
S
S
L
W
A
L
E
S
-