@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1336: (2016-04-30 )
MTRYDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRNPTGSIKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLICVMPENTSVERRQLLELYGAQIIFSAAEGGSNTAVATAKELAATNPSWVMLYQYGNPANTDSHYCGTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREHVANVKIVAAEPRYGEGVYALRNMDEGFVPELYDPEILTARYSVGAVDAVRRTRELVHTEGIFAGISTGAVLHAALGVGAGALAAGERADIALVVADAGWKYLSTGAYAGSLDDAETALEGQLWA
Atome Classification :
(47 SA)
.........10........20..--......30........40........50........60........70-.--...-....80........90........100.......110.......120....----...130---.......140..-.....150.......160........170.--.-.--...-.180.......190.....--..200.......210-----------.-------..-------.-------------.-------....220.......230.......240.......250.......260.......270.......280-.......290.......300.......310.......320.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
R
Y
D
S
L
L
Q
A
LGNTPLV
G
L
Q
RLS--PRWDDGRDGP
H
V
R
L
W
A
K
LEDRNPTGSIKD
R
P
A
V
R
M
I
E
Q
AEADGLLRPG-
A
--
T
I
L
-EPTSGNTG
I
S
L
A
M
A
ARLKG
Y
R
L
I
C
V
MPENT
S
V
E
R
R
Q
L
L
E
L
YG
A
Q
I
I
F
S
AAE----GGSNTA---
V
A
T
A
K
E
LAATNP-
S
W
V
M
L
Y
QYGNPANTDSH-YCGT
G
P
E
L
L
A
D
L
--
P
-
E
--
I
T
H
-
F
V
AGLGT
T
G
T
LM
G
T
G
R
F
L
R
--
E
HVAN
V
K
I
V
AAEP-------------R-------YG-------E-------------
G
-------
V
Y
A
L
RNMDEGFVPELYDPE
I
L
T
A
RYSVG
A
V
D
A
V
R
R
T
R
E
L
V
H
TEGIFAGIS
T
G
A
V
L
H
A
A
L
GVG
A
G
ALA-AGERA
D
I
A
L
V
V
ADAG
W
K
Y
LSTGAYAGSLD
D
A
E
T
ALEGQLWA
1
PsiBlast_PDB
96.20
100%
-83
- C4 -
3DWG
1
CYSM_MYCTU
A:
[3-325]
M
T
R
Y
D
S
L
L
Q
A
L
G
N
T
P
L
V
G
L
Q
R
L
S
--
P
R
W
D
D
G
R
D
G
P
H
V
R
L
W
A
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
L
L
R
P
G
-
A
--
T
I
L
-
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
F
S
A
A
E
----
G
G
S
N
T
A
---
V
A
T
A
K
E
L
A
A
T
N
P
-
S
W
V
M
L
Y
Q
Y
G
N
P
A
N
T
D
S
H
-
Y
C
G
T
G
P
E
L
L
A
D
L
--
P
-
E
--
I
T
H
-
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
--
E
H
V
A
N
V
K
I
V
A
A
E
P
-------------
R
-------
Y
G
-------
E
-------------
G
-------
V
Y
A
L
R
N
M
D
E
G
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
V
L
H
A
A
L
G
V
G
A
G
A
L
A
-
A
G
E
R
A
D
I
A
L
V
V
A
D
A
G
W
K
Y
L
S
T
G
A
Y
A
G
S
L
D
D
A
E
T
A
L
E
G
Q
L
W
A
111
HHSearch
95.56
99%
-83
- C4 -
3DWG
1
CYSM_MYCTU
A:
[4-325]
-
T
R
Y
D
S
L
L
Q
A
L
G
N
T
P
L
V
G
L
Q
R
L
S
--
P
R
W
D
D
G
R
D
G
P
H
V
R
L
W
A
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
L
L
R
P
G
-
A
--
T
I
L
-
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
F
S
A
A
E
----
G
G
S
N
T
A
---
V
A
T
A
K
E
L
A
A
T
N
P
-
S
W
V
M
L
Y
Q
Y
G
N
P
A
N
T
D
S
H
-
Y
C
G
T
G
P
E
L
L
A
D
L
--
P
-
E
--
I
T
H
-
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
--
E
H
V
A
N
V
K
I
V
A
A
E
P
-------------
R
-------
Y
G
-------
E
-------------
G
-------
V
Y
A
L
R
N
M
D
E
G
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
V
L
H
A
A
L
G
V
G
-
A
G
A
L
A
A
G
E
R
A
D
I
A
L
V
V
A
D
A
G
W
K
Y
L
S
T
G
A
Y
A
G
S
L
D
D
A
E
T
A
L
E
G
Q
L
W
A
21
PsiBlast_CBE
95.14
100%
-91
- C4 -
3DWG
1
CYSM_MYCTU
B:
[3-325]
M
T
R
Y
D
S
L
L
Q
A
L
G
N
T
P
L
V
G
L
Q
R
L
S
--
P
R
W
D
D
G
R
D
G
P
H
V
R
L
W
A
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
L
L
R
P
G
-
A
--
T
I
L
-
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
F
S
A
A
--------
N
T
A
---
V
A
T
A
K
E
L
A
A
T
N
P
-
S
W
V
M
L
Y
Q
Y
G
N
P
A
N
T
D
S
H
-
Y
C
G
T
G
P
E
L
L
A
D
L
--
P
-
E
--
I
T
H
-
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
--
E
H
V
A
N
V
K
I
V
A
A
E
P
-------------
R
-------
Y
G
-------
E
-------------
G
-------
V
Y
A
L
R
N
M
D
E
G
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
V
L
H
A
A
L
G
V
G
A
G
A
L
A
-
A
G
E
R
A
D
I
A
L
V
V
A
D
A
G
W
K
Y
L
S
T
G
A
Y
A
G
S
L
D
D
A
E
T
A
L
E
G
Q
L
W
A
2
PsiBlast_PDB
95.04
99%
-89
- C4 -
3DKI
-
CYSM_MYCTU
A:
[6-316]
--
R
Y
D
S
L
L
Q
A
L
G
N
T
P
L
V
G
L
Q
R
L
S
--
P
R
W
D
D
G
R
D
G
P
H
V
R
L
W
A
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
L
L
R
P
G
-
A
--
T
I
L
-
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
F
S
A
A
E
----
G
G
S
N
T
A
---
V
A
T
A
K
E
L
A
A
T
N
P
-
S
W
V
M
L
Y
Q
Y
G
N
P
A
N
T
D
S
H
-
Y
C
G
T
G
P
E
L
L
A
D
L
--
P
-
E
--
I
T
H
-
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
--
E
H
V
A
N
V
K
I
V
A
A
E
P
-------------
R
-------
Y
G
-------
E
-------------
G
-------
V
Y
A
L
R
N
M
D
E
G
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
V
L
H
A
A
L
G
V
G
A
G
A
L
A
-
A
G
E
R
A
D
I
A
L
V
V
A
D
A
G
W
K
Y
L
S
T
G
A
Y
A
G
S
L
D
D
A
----------
22
PsiBlast_CBE
91.97
99%
-86
- C4 -
3DWI
3
CYSM_MYCTU
B:
[1-312]
M
T
R
Y
D
S
L
L
Q
A
L
G
N
T
P
L
V
G
L
Q
R
L
S
--
P
R
W
D
D
G
R
D
G
P
H
V
R
L
W
A
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
L
L
R
P
G
-
A
--
T
I
L
-
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
F
S
A
A
-------
S
N
T
A
---
V
A
T
A
K
E
L
A
A
T
N
P
-
S
W
V
M
L
Y
Q
Y
G
N
P
A
N
T
D
S
H
-
Y
C
G
T
G
P
E
L
L
A
D
L
--
P
-
E
--
I
T
H
-
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
--
E
H
V
A
N
V
A
I
V
A
A
E
P
-------------
R
-------
Y
G
-------
E
-------------
G
-------
V
Y
A
L
R
N
M
D
E
G
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
V
L
H
A
A
L
G
V
G
A
G
A
L
A
-
A
G
E
R
A
D
I
A
L
V
V
A
D
A
G
W
K
Y
L
S
T
G
A
Y
A
G
S
L
D
D
-----------
43
PsiBlast_CBE
74.04
39%
-82
- C4 -
3X43
1
DCSD_STRLA
F:
[2-305]
-
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
--
P
E
--------
H
T
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
----
L
G
S
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
--
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
AG
K
-
R
--
L
D
H
-
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
P
E
V
R
V
V
A
L
E
P
-------------
S
NAAMLA-
R
G
-------
E
W------------
S
-------
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
---
A
E
H
-
A
P
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
G
---------------
41
PsiBlast_CBE
73.75
39%
-82
- C4 -
3X43
1
DCSD_STRLA
H:
[2-305]
-
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
--
P
E
--------
H
T
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
----
L
G
S
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
--
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
AG
K
-
R
--
L
D
H
-
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
P
E
V
R
V
V
A
L
E
P
-------------
S
NAAMLA-
R
G
-------
E
W------------
S
-------
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
---
A
E
H
-
A
P
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
G
---------------
44
PsiBlast_CBE
73.04
39%
-85
- C4 -
3X43
1
DCSD_STRLA
E:
[2-305]
-
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
--
P
E
--------
H
T
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
----
L
G
S
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
--
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
AG
K
-
R
--
L
D
H
-
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
P
E
V
R
V
V
A
L
E
P
-------------
S
NAAMLA-
R
G
-------
E
W------------
S
-------
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
---
A
E
H
-
A
P
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
G
---------------
46
PsiBlast_CBE
72.99
39%
-86
- C4 -
3X43
1
DCSD_STRLA
C:
[2-305]
-
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
--
P
E
--------
H
T
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
----
L
G
S
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
--
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
AG
K
-
R
--
L
D
H
-
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
P
E
V
R
V
V
A
L
E
P
-------------
S
NAAMLA-
R
G
-------
E
W------------
S
-------
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
---
A
E
H
-
A
P
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
G
---------------
47
PsiBlast_CBE
72.98
39%
-83
- C4 -
3X43
1
DCSD_STRLA
B:
[2-305]
-
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
--
P
E
--------
H
T
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
----
L
G
S
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
--
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
AG
K
-
R
--
L
D
H
-
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
P
E
V
R
V
V
A
L
E
P
-------------
S
NAAMLA-
R
G
-------
E
W------------
S
-------
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
---
A
E
H
-
A
P
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
G
---------------
121
HHSearch
72.63
36%
-76
- C4 -
3TBH
2
?
A:
[12-319]
---
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
L
N
--
N
-
T
-------
K
A
K
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
G
K
S
--
I
V
V
-
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
A
A
----
L
G
M
K
G
A
---
V
A
M
A
K
K
I
V
A
A
N
P
-
N
A
V
L
A
D
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
--
N
-
H
N-
V
D
C
-
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
--
K
M
G
S
H
A
R
I
V
A
V
E
P
-------------
T
-------
E
S
-------
P
VLS
G
G
K
P
------
G
-------
P
H
K
I
Q
G
I
G
P
G
F
V
P
D
V
L
D
R
S
L
I
D
E
V
L
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
-
E
R
P
E
-
M
-
E
G
K
T
I
V
T
V
I
P
S
F
G
E
R
Y
L
S
T
T
L
Y
R
S
V
R
D
E
-----------
42
PsiBlast_CBE
72.63
39%
-83
- C4 -
3X43
1
DCSD_STRLA
G:
[2-305]
-
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
--
P
E
--------
H
T
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
----
L
G
S
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
--
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
AG
K
-
R
--
L
D
H
-
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
P
E
V
R
V
V
A
L
E
P
-------------
S
NAAMLA-
R
G
-------
E
W------------
S
-------
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
---
A
E
H
-
A
P
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
G
---------------
48
PsiBlast_CBE
72.05
39%
-82
- C4 -
3X43
1
DCSD_STRLA
A:
[2-305]
-
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
--
P
E
--------
H
T
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
----
L
G
S
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
--
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
AG
K
-
R
--
L
D
H
-
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
P
E
V
R
V
V
A
L
E
P
-------------
S
NAAMLA-
R
G
-------
E
W------------
S
-------
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
---
A
E
H
-
A
P
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
G
---------------
45
PsiBlast_CBE
71.73
39%
-82
- C4 -
3X43
1
DCSD_STRLA
D:
[2-305]
-
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
--
P
E
--------
H
T
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
----
L
G
S
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
--
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
AG
K
-
R
--
L
D
H
-
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
P
E
V
R
V
V
A
L
E
P
-------------
S
NAAMLA-
R
G
-------
E
W------------
S
-------
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
---
A
E
H
-
A
P
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
G
---------------
54
PsiBlast_CBE
71.43
36%
-74
- C4 -
3VBE
1
?
B:
[31-337]
--------
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
T
---------
E
G
C
G
A
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
G
K
T
--
T
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
P
A
----
K
G
M
G
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
P
-
N
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
--
N
G
Q
--
V
D
I
-
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
N
P
N
V
K
I
Y
G
V
E
P
-------------
S
-------
E
S
-------
N
VLNG
G
K
P
------
G
-------
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
--
A
Q
L
P
-
E
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
E
L
R
Q
E
A
E
N
--------
120
HHSearch
71.11
37%
-68
- C4 -
3VC3
1
?
A:
[25-337]
--
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
T
--
E
G
C
-------
G
A
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
A
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
G
K
T
--
T
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
P
A
----
K
G
M
G
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
P
-
N
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
--
N
-
G
Q-
V
D
I
-
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
N
P
N
V
K
I
Y
G
V
E
P
-------------
S
-------
E
S
-------
N
-------------
V
LNG
G
K
P
G
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
A
-
Q
L
P
E
-
N
-
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
E
L
R
Q
E
A
E
N
--------
62
PsiBlast_CBE
71.00
36%
-69
- C4 -
3VC3
1
?
E:
[31-337]
--------
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
T
---------
E
G
C
G
A
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
A
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
G
K
T
--
T
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
P
A
----
K
G
M
G
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
P
-
N
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
--
N
G
Q
--
V
D
I
-
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
N
P
N
V
K
I
Y
G
V
E
P
-------------
S
-------
E
S
-------
N
VLNGGKP------
G
-------
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
--
A
Q
L
P
-
E
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
E
L
R
Q
E
A
E
N
--------
55
PsiBlast_CBE
70.92
36%
-77
- C4 -
3VBE
1
?
A:
[31-337]
--------
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
T
---------
E
G
C
G
A
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
G
K
T
--
T
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
P
A
----
K
G
M
G
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
P
-
N
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
--
N
G
Q
--
V
D
I
-
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
N
P
N
V
K
I
Y
G
V
E
P
-------------
S
-------
E
S
-------
N
VLNG
G
K
P
------
G
-------
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
--
A
Q
L
P
-
E
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
E
L
R
Q
E
A
E
N
--------
52
PsiBlast_CBE
70.85
36%
-77
- C4 -
3VBE
1
?
D:
[31-337]
--------
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
T
---------
E
G
C
G
A
Y
V
A
V
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
G
K
T
--
T
L
I
-
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
P
A
----
K
G
M
G
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
P
-
N
A
H
M
L
Q
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
E
D
T
--
N
G
Q
--
V
D
I
-
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
N
P
N
V
K
I
Y
G
V
E
P
-------------
S
-------
E
S
-------
N
VLNGGKP------
G
-------
P
H
H
I
T
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
N
T
V
A
A
L
R
L
--
A
Q
L
P
-
E
N
K
G
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
S
V
L
F
Q
E
L
R
Q
E
A
E
N
--------
116
HHSearch
70.67
40%
-75
- C4 -
3X44
1
DCSD_STRLA
A:
[2-310]
-
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
--
P
-
E
-------
H
T
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
----
L
G
S
K
G
G
---
N
L
I
A
D
E
L
A
E
-
K
Y
-
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
--
A
-
G
K
R
L
D
H
-
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
P
E
V
R
V
V
A
L
E
P
-------------
S
-------
N
A
-------
A
MLARGEW------
S
-------
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
A
-
E
H
A
---
P
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
G
V
D
E
G
S
----------
49
PsiBlast_CBE
70.12
39%
-76
- C4 -
3X44
1
DCSD_STRLA
B:
[2-305]
-
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
--
P
E
--------
H
T
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
----
L
G
S
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
--
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
AG
K
-
R
--
L
D
H
-
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
P
E
V
R
V
V
A
L
E
P
-------------
S
NAAMLA-
R
G
-------
E
W------------
S
-------
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
---
A
E
H
-
A
P
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
G
---------------
50
PsiBlast_CBE
69.76
39%
-76
- C4 -
3X44
1
DCSD_STRLA
A:
[2-305]
-
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
A
--
P
E
--------
H
T
S
V
Y
V
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
G
-
D
--
T
I
V
-
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
----
L
G
S
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
--
G
W
F
R
A
R
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
A
D
F
AG
K
-
R
--
L
D
H
-
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
R
P
E
V
R
V
V
A
L
E
P
-------------
S
NAAMLA-
R
G
-------
E
W------------
S
-------
P
H
Q
I
Q
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
T
V
A
T
A
L
S
I
---
A
E
H
-
A
P
E
G
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
T
F
L
F
D
G
---------------
117
HHSearch
69.22
39%
-77
- C4 -
2Q3B
5
CYSK_MYCTU
A:
[5-303]
-
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
T
--
D
G
A
-------
V
A
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
D
-
T
--
I
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
----
D
G
M
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
Q
-
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
-
A
I
H
R
V
T
T
A
E
E
V
W
R
D
T
--
D
-
G
K-
V
D
I
-
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
K
P
S
A
R
F
V
A
V
E
P
-------------
A
-------
A
S
-------
P
VLS----------
G
G
Q
K
G
---
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
-
R
R
P
E
-
N
-
A
G
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
----------------------
9
PsiBlast_PDB
69.19
41%
-76
- C4 -
2ECO
2
?
A:
[6-302]
---------
A
I
G
K
T
P
V
V
R
L
A
K
V
V
---------
E
P
D
M
A
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
-
S
G
Q
V
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
RR
M
L
A
A
R
E
E
A
---
L
R
L
K
E
E
L
G
A
F
M
P
-
D
-----
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
--
E
G
R
--
I
D
A
-
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
P
H
V
K
V
I
A
V
E
P
-------------
A
-------
R
S
-------
N
VLSG
G
K
M
------
G
-------
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
-
A
R
E
L
G
-
P
G
K
R
--
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
----------------
13
PsiBlast_PDB
68.85
38%
-76
- C4 -
3ZEI
4
CYSK_MYCTU
A:
[1-300]
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
T
---------
D
G
A
V
A
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
D
-
T
--
I
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
----
D
G
M
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
Q
-
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
--
D
G
K
--
V
D
I
-
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
K
P
S
A
R
F
V
A
V
E
P
-------------
A
-------
A
S
PVLSG
G
Q
K
-------------
G
-------
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
P
E
N
-
A
G
K
L
--
I
V
V
V
L
P
D
F
G
E
R
Y
L
----------------------
15
PsiBlast_PDB
68.83
38%
-72
- C4 -
2Q3B
5
CYSK_MYCTU
A:
[4-303]
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
T
---------
D
G
A
V
A
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
D
-
T
--
I
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
----
D
G
M
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
Q
-
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
--
D
G
K
--
V
D
I
-
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
K
P
S
A
R
F
V
A
V
E
P
-------------
A
-------
A
S
PVLS
G
G
Q
K
-------------
G
-------
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
P
E
N
-
A
G
K
L
--
I
V
V
V
L
P
D
F
G
E
R
Y
L
----------------------
14
PsiBlast_PDB
68.82
38%
-67
- C4 -
2Q3D
2
CYSK_MYCTU
A:
[4-309]
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
T
---------
D
G
A
V
A
D
I
V
A
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
D
-
T
--
I
I
L
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
----
D
G
M
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
Q
-
R
Y
F
V
P
Q
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
--
D
G
K
--
V
D
I
-
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
K
P
S
A
R
F
V
A
V
E
P
-------------
A
-------
A
S
PVLSG
G
Q
K
-------------
G
-------
P
H
P
I
Q
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
A
T
V
A
A
L
Q
V
A
R
R
P
E
N
-
A
G
K
L
--
I
V
V
V
L
P
D
F
G
E
R
Y
L
S
T
P
L
F
A
----------------
126
HHSearch
68.63
41%
-83
- C4 -
2V03
3
CYSM_ECOLI
A:
[2-294]
----
S
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
G
--
P
D
N
-------
G
S
E
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
-
D
--
V
L
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
----
Q
G
M
E
G
A
---
R
D
L
A
L
E
M
A
N
-
R
G
-
E
G
K
L
L
D
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
--
G
-
G
R-
I
T
H
-
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
K
P
V
T
I
V
G
L
Q
P
-------------
E
-------
E
G
-------
S
-------------
S
-------
I
P
G
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
-
A
A
N
----
P
D
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
G
E
---------------
33
PsiBlast_CBE
68.12
41%
-76
- C4 -
2EFY
2
?
B:
[6-302]
---------
A
I
G
K
T
P
V
V
R
L
A
K
V
V
---------
E
P
D
M
A
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
-
S
GQ
V
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
RRML
A
A
R
E
E
A
---
L
R
L
K
E
E
L
G
A
F
M
P
-
D
-----
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
--
E
G
R
--
I
D
A
-
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
P
H
V
K
V
I
A
V
E
P
-------------
A
-------
R
S
-------
N
VLSGGKM------
G
-------
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
-
A
R
E
L
G
-
P
G
K
R
--
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
----------------
10
PsiBlast_PDB
67.96
41%
-73
- C4 -
2ECQ
2
?
A:
[6-302]
---------
A
I
G
K
T
P
V
V
R
L
A
K
V
V
---------
E
P
D
M
A
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
-
S
G
Q
V
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
RR
M
L
A
A
R
E
E
A
---
L
R
L
K
E
E
L
G
A
F
M
P
-
D
-----
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
--
E
G
R
--
I
D
A
-
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
P
H
V
K
V
I
A
V
E
P
-------------
A
-------
R
S
-------
N
VLSG
G
K
M
------
G
-------
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
-
A
R
E
L
G
-
P
G
K
R
--
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
----------------
4
PsiBlast_PDB
67.86
41%
-77
- C4 -
2V03
3
CYSM_ECOLI
A:
[3-292]
-----
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
G
--
P
--
D
N
G
S
E
-----
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
-
D
--
V
L
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
----
Q
G
M
E
G
A
---
R
D
L
A
L
E
M
-
A
N
R
G
-
E
G
K
L
L
D
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G-
G
-
R
--
I
T
H
-
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
K
P
V
T
I
V
G
L
Q
P
-------------
E
-------
E
G
-------
S
-------------
S
-------
I
P
G
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
----
A
-
A
N
P
D
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
-----------------
11
PsiBlast_PDB
67.84
41%
-76
- C4 -
2EFY
2
?
A:
[6-302]
---------
A
I
G
K
T
P
V
V
R
L
A
K
V
V
---------
E
P
D
M
A
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
-
S
G
Q
V
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
RR
M
L
A
A
R
E
E
A
---
L
R
L
K
E
E
L
G
A
F
M
P
-
D
-----
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
--
E
G
R
--
I
D
A
-
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
P
H
V
K
V
I
A
V
E
P
-------------
A
-------
R
S
-------
N
VLSG
G
K
M
------
G
-------
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
-
A
R
E
L
G
-
P
G
K
R
--
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
----------------
8
PsiBlast_PDB
67.82
41%
-75
- C4 -
1VE1
1
?
A:
[6-302]
---------
A
I
G
K
T
P
V
V
R
L
A
K
V
V
---------
E
P
D
M
A
E
V
W
V
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
G
-
S
G
Q
V
I
V
-
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
RR
M
L
A
A
R
E
E
A
---
L
R
L
K
E
E
L
G
A
F
M
P
-
D
-----
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
--
E
G
R
--
I
D
A
-
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
I
P
H
V
K
V
I
A
V
E
P
-------------
A
-------
R
S
-------
N
VLSG
G
K
M
------
G
-------
Q
H
G
F
Q
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
-
A
R
E
L
G
-
P
G
K
R
--
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
T
P
L
Y
A
----------------
25
PsiBlast_CBE
67.47
41%
-77
- C4 -
2BHS
1
CYSM_ECOLI
B:
[3-292]
-----
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
G
--
P
--
D
N
G
S
E
-----
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
-
D
--
V
L
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
----
Q
G
M
E
G
A
---
R
D
L
A
L
E
M
-
A
N
R
G
-
E
G
K
L
L
D
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G-
G
-
R
--
I
T
H
-
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
K
P
V
T
I
V
G
L
Q
P
-------------
E
-------
E
G
-------
S
-------------
S
-------
I
P
G
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
----
K
-
A
N
P
D
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
-----------------
82
PsiBlast_CBE
67.45
33%
-73
- C4 -
4IL5
1
?
A:
[14-319]
---
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
T
EH
P
R
I
K
K
G
-----
T
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
G
-
M
--
E
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
G
K
----
K
G
M
P
G
A
---
I
E
E
V
N
K
M
I
K
E
N
P
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
-
T
A
N
E
I
W
E
D
T
--
D
G
E
--
V
D
I
-
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
K
K
G
I
K
I
I
A
V
E
P
-------------
E
ESAVLE
G
K
A
-------
K
-------------
G
-------
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
--
G
L
K
E
A
E
K
P
-
E
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
-----------------
78
PsiBlast_CBE
67.28
33%
-67
- C4 -
1D6S
2
CYSK_SALTY
B:
[4-319]
---
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
G
------------
N
G
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
-
V
--
E
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
----
K
G
M
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
--
D
G
Q
--
V
D
V
-
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
T
D
L
I
T
V
A
V
E
P
TDSPVIAQALAGE
E
-------
I
K
-------
P
-------------
G
-------
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
--
E
-
S
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
T
E
K
E
---------
83
PsiBlast_CBE
67.18
33%
-73
- C4 -
4JBN
2
?
A:
[14-319]
---
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
T
EH
P
R
I
K
K
G
-----
T
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
G
-
M
--
E
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
G
K
----
K
G
M
P
G
A
---
I
E
E
V
N
K
M
I
K
E
N
P
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
-
T
A
N
E
I
W
E
D
T
--
D
G
E
--
V
D
I
-
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
K
K
G
I
K
I
I
A
V
E
P
-------------
E
ESAVLEG
K
A
-------
K
-------------
G
-------
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
--
G
L
K
E
A
E
K
P
-
E
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
-----------------
79
PsiBlast_CBE
67.00
33%
-67
- C4 -
1D6S
2
CYSK_SALTY
A:
[4-319]
---
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
G
------------
N
G
R
I
L
A
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
G
-
V
--
E
L
V
-
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
----
K
G
M
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
P
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
--
D
G
Q
--
V
D
V
-
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
K
T
D
L
I
T
V
A
V
E
P
TDSP
V
I
A
Q
A
L
A
GE
E
-------
I
K
-------
P
-------------
G
-------
P
H
K
I
Q
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
A
V
A
A
A
L
K
L
Q
E
D
--
E
-
S
F
T
N
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
T
A
L
F
A
D
L
F
T
E
K
E
---------
5
PsiBlast_PDB
66.90
41%
-78
- C4 -
2BHS
1
CYSM_ECOLI
A:
[3-292]
-----
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
G
--
P
--
D
N
G
S
E
-----
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
-
D
--
V
L
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
----
Q
G
M
E
G
A
---
R
D
L
A
L
E
M
-
A
N
R
G
-
E
G
K
L
L
D
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G
-
G
-
R
--
I
T
H
-
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
K
P
V
T
I
V
G
L
Q
P
-------------
E
-------
E
G
-------
S
-------------
S
-------
I
P
G
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
----
K
-
A
N
P
D
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
-----------------
85
PsiBlast_CBE
66.41
33%
-63
- C4 -
4JBL
2
?
B:
[14-319]
---
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
T
EH
P
R
I
K
K
G
-----
T
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
G
-
M
--
E
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
G
K
----
K
G
M
P
G
A
---
I
E
E
V
N
K
M
I
K
E
N
P
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
-
T
A
N
E
I
W
E
D
T
--
D
G
E
--
V
D
I
-
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
K
K
G
I
K
I
I
A
V
E
P
-------------
E
ESAVLEG
K
A
-------
K
-------------
G
-------
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
--
G
L
K
E
A
E
K
P
-
E
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
-----------------
23
PsiBlast_CBE
65.71
41%
-76
- C4 -
2BHS
1
CYSM_ECOLI
D:
[3-292]
-----
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
G
--
P
--
D
N
G
S
E
-----
V
W
L
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
G
-
D
--
V
L
I
-
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
----
Q
G
M
E
G
A
---
R
D
L
A
L
E
M
-
A
N
R
G
-
E
G
K
L
L
D
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
Q
Q
T
G-
G
-
R
--
I
T
H
-
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
S
K
P
V
T
I
V
G
L
Q
P
-------------
E
-------
E
G
-------
S
-------------
S
-------
I
P
G
I
R
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
A
V
A
G
A
L
R
V
A
----
K
-
A
N
P
D
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
T
G
V
F
-----------------
124
HHSearch
65.43
37%
-65
- C4 -
4LMB
3
?
A:
[9-317]
-
L
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
I
P
--
V
A
E
G
----
V
-
K
A
R
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
D
K
T
--
I
L
V
-
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
G
S
----
Q
G
M
E
G
A
---
I
T
R
A
E
E
I
V
E
N
T
P
-
N
A
Y
S
L
Q
Q
F
R
N
P
A
N
P
K
I
H
-
R
E
T
T
A
E
E
I
W
A
D
T
--
D
-
G
L-
V
D
I
-
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
--
P
R
R
P
Q
F
Q
A
I
A
V
E
P
-------------
S
-------
N
S
-------
P
-------------
V
LSG
G
Q
P
G
P
H
K
I
Q
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
-
K
R
P
E
-
N
-
E
D
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
K
D
---------------
56
PsiBlast_CBE
65.18
36%
-64
- C4 -
3PC4
3
?
A:
[53-348]
-----
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
-------
A
S
D
G
I
E
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
G
-
Y
--
T
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
----
A
A
Y
D
S
P
EG
L
I
Y
V
A
Q
Q
L
Q
R
E
T
P
-
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
--
D
N
K
--
V
D
M
-
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
V
P
S
C
Q
I
V
G
V
D
P
---------------------
Y
G
-------
S
ILARPAELNKTDV
Q
-------
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
-
H
A
R
K
L
K
-
K
G
Q
R
C
V
V
I
L
--------------------------------
80
PsiBlast_CBE
65.01
32%
-80
- C4 -
4AIR
5
?
B:
[35-343]
-----
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
L
----------
N
N
T
K
A
K
V
V
L
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
G
K
S
--
V
V
V
-
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
A
A
----
L
G
M
K
G
A
---
V
T
M
A
K
K
I
V
T
A
N
P
-
N
A
V
L
A
D
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
E
Q
T
--
N
-
H
N-
V
D
C
-
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
--
K
M
G
S
H
A
R
I
V
A
V
E
P
-------------
M
-------
E
----------------------------------------------
D
R
S
L
I
D
E
V
F
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
N
V
Y
A
A
L
K
I
A
E
R
P
E
M
-
E
G
K
--
T
I
V
T
I
I
P
S
F
G
E
R
Y
L
S
T
A
L
Y
R
S
V
R
D
E
V
S
S
--------
75
PsiBlast_CBE
64.17
33%
-66
- C4 -
3BM5
4
?
B:
[13-318]
---
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
T
EH
P
R
I
K
K
G
-----
T
R
I
L
V
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
G
-
M
--
E
I
I
-
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
G
K
----
K
G
M
P
G
A
---
I
E
E
V
N
K
M
I
K
E
N
P
G
K
Y
F
V
A
N
Q
F
G
N
P
D
N
T
A
A
H
-
H
Y
-
T
A
N
E
I
W
E
D
T
--
D
G
E
--
V
D
I
-
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
K
K
G
I
K
I
I
A
V
E
P
-------------
E
ESAVLEG
K
A
-------
K
-------------
G
-------
P
H
G
I
Q
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
A
I
L
A
--
G
L
K
E
A
E
K
P
-
E
N
E
G
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
T
D
L
Y
-----------------
57
PsiBlast_CBE
63.93
36%
-64
- C4 -
3PC3
2
?
A:
[53-348]
-----
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
P
-------
A
S
D
G
I
E
C
E
M
Y
A
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
G
-
Y
--
T
I
I
-
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
----
A
A
Y
D
S
P
EG
L
I
Y
V
A
Q
Q
L
Q
R
E
T
P
-
N
S
I
V
L
D
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
W
Q
L
--
D
N
K
--
V
D
M
-
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
V
P
S
C
Q
I
V
G
V
D
P
---------------------
Y
G
-------
S
ILARPAELNKTDV
Q
-------
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
A
M
H
A
A
L
E
-
H
A
R
K
L
K
-
K
G
Q
R
C
V
V
I
L
--------------------------------
51
PsiBlast_CBE
63.34
37%
-59
- C4 -
4LMB
3
?
A:
[14-315]
------
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
I
P
-------
V
A
E
G
V
K
A
R
I
V
V
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
D
-
K
--
T
I
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
G
S
----
Q
G
M
E
G
A
---
I
T
R
A
E
E
I
V
E
N
T
P
-
N
A
Y
S
L
Q
Q
F
R
N
P
A
N
P
K
I
H
-
R
E
T
T
A
E
E
I
W
A
D
T
--
D
-
G
--
L
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
--
P
R
R
P
Q
F
Q
A
I
A
V
E
P
-------------
S
-------
N
S
PVLSG
G
Q
P
-------------
G
-------
P
H
K
I
Q
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
A
L
W
A
A
I
Q
V
G
K
R
--
P
-
E
N
E
D
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
T
A
L
F
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