@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1349: (2016-05-01 )
MIRTWIALVPNDHRARLIGFALLAFCSVVARAVGTVLLVPLMAALFGEAPQRAWLWLGWLSAATVAGWVLDAVTARIGIELGFAVLNHTQHDVADRLPVVRLDWFTAENTATARQAIAATGPELVGLVVNLVTPLTSAILLPAVIALALLPISWQLGVAALAGVPLLLGALWASAAFARRADTAADKANTALTERIIEFARTQQALRAARRVEPARSLVGNALASQHTATMRLLGMQIPGQLLFSIASQLALIVLAGTTAALTITGTLTVPEAIALIVVMVRYLEPFTAVSELAPALESTRATLGRIGSVLTAPVMVAGSGTWRDGAVVPRIEFDDVAFGYDGGSGPVLDGVSFCLQPGTTTAIVGPSGCGKSTILALIAGLHQPTRGRVLIDGTDVATLDARAQQAVCSVVFQHPYLFHGTIRDNVFAADPGASDDQFAQAVRLARVDELIARLPDGANTIVGEAGSALSGGERQRVSIARALLKAAPVLLVDEATSALDAENEAAVVDALAADPRSRTRVIVAHRLASIRHADRVLFVDDGRVVEDGSISELLTAGGRFSQFWRQQHEAAEWQILAE
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------.........10........20........30........40........50--.----.-----.--.-.---...----.60......----..70........80........90........100....--.--..110.......120.......130........140....-...150.....--..160....--...170.------..----....180.......190.......200.......210.......220.......230.......240.......250.......260.....--..270.......280.......290.......300.......310........320.----.-..-...330-----........340..-..-...350.......360.......370.......380....---...390.......400.......410.......420.....-..430.---......440.......450.......460.......470.......480.......490.......500.......510...--.--...520.......530.......540.......550.....--..560.......570.......----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------M
I
R
T
W
I
A
LVPND
H
R
A
R
L
I
G
F
A
L
L
A
F
C
S
V
V
A
R
A
V
G
T
V
L
L
V
P
L
M
A
A
L
FGEAP---
Q
----
R
-----
A
--
W
-
L
---
W
L
G
----
W
L
S
A
A
T
V
A
G
----
W
V
L
D
A
V
T
A
R
I
G
I
E
L
G
F
A
V
L
NH
T
Q
H
D
V
A
DRL
P
V
V
R
L
D
W
FT--A--EN
T
A
T
A
R
Q
A
I
AAT
G
P
E
L
V
G
L
V
V
N
-
L
V
T
P
L
T
S
A
I
L
L
P
A
V
I
A
-
L
A
L
LPIS
W
Q
L
G
--
V
A
A
L
A
G
V
P
L
--
L
L
G
A
L
W
A
------
S
A
----
A
F
ARRADTAADK
A
N
T
A
L
T
E
R
I
I
E
F
A
R
T
Q
Q
A
L
R
A
A
RRV
E
P
A
R
S
L
V
G
N
A
L
A
S
Q
H
T
A
T
M
R
L
L
GMQI
P
G
Q
L
L
F
S
I
A
S
Q
L
A
L
I
V
L
AG
T
T
A
A
L
T
I
T
G
T--L
T
V
P
E
A
I
A
L
I
V
V
M
V
R
YL
E
P
F
T
A
V
S
E
L
A
P
A
L
E
S
T
R
A
T
L
G
R
I
G
S
V
L-TA
P
V
M
V
AGSGTW----R-DG-
A
V
V
P
-
R
-----
I
EFD
D
V
A
F
GYDGG-SG-
P
V
L
D
G
V
S
F
C
LQPGT
T
T
A
I
VGPSGC
G
K
S
T
I
L
A
L
I
A
G
LHQPT---R
G
R
V
L
IDGT
D
V
A
T
L
D
A
R
A
Q
Q
A
V
C
S
V
V
FQH
P
Y
L
F
H
G
TIRD
N
V
-
F
AADPG---A
S
D
D
Q
F
A
Q
A
V
R
L
A
R
V
D
E
L
I
A
RLPDGA
N
T
I
VGEAGSALSGG
E
R
Q
R
V
S
I
A
R
A
L
L
KAA
P
V
L
L
VDEATSALDAEN
E
A
A
V
V
D
A
LAAD--P--RS
R
T
R
V
I
V
A
H
R
L
A
S
IRHA
D
R
V
L
F
VDD
G
R
V
VEDG
S
I
S
E
L
L
TA--GG
R
F
S
Q
F
W
R
Q
QHEAA
E
W
Q
I
LAE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
85.25
23%
-119
- C2 -
4Q4H
-
Y288_THEMA
B:
[26-591]
----------------------------------------------------------------------------------------------------
R
R
L
L
G
Y
L
-
R
P
H
T
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
R
F--
D
----
L
-----
L
--
P
-
R
---
Y
M
L
----
I
L
G
T
I
Y
A
L
T
----
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
--
R
--
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
-
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
-
I
M
M
F
R
V
N
V
I
L
S
--
L
V
T
L
S
I
V
P
L
--
T
V
L
I
T
Q
I
------
V
S
----
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
--
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
-
D
L
E
E
E
K
D
D
P
D
A
V
----
E
-
L
R
-
E
V
R
G
-
E
-----
I
E
F
K
N
V
W
F
S
Y
D
K
K
--
K
-
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
-
K
Y
G
N
P
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
78.53
24%
-119
- C2 -
4MYC
-
ATM1_YEAST
A:
[107-676]
--------------------------------------------------------------------------------------------------------------
V
R
I
R
V
L
I
A
L
G
L
L
I
S
A
K
I
L
N
V
Q
V
P
F
F
F
K
Q
T
I
D
S
M
N
I
A
W
D
D--
P
----
T
-----
V
AL
P
A
A
I
G
L
T
I
L
----
C
Y
G
V
A
R
F
G
S
----
V
L
F
G
E
L
R
N
A
V
F
A
K
V
A
Q
N
A
I
R
T
V
S
L
Q
T
F
Q
H
L
M
K
L
D
L
G
W
H
L
--
S
--
R
Q
T
G
G
L
T
R
A
M
D
R
G
T
K
G
I
S
Q
V
L
T
A
-
M
V
F
H
I
I
P
I
S
F
E
I
S
V
V
C
G
I
L
T
Y
Q
F
G
A
S
F
A
--
A
I
T
F
S
T
M
L
L
--
Y
S
I
F
T
I
K
------
T
T
----
A
W
R
T
H
F
R
R
D
A
N
K
A
D
N
K
A
A
S
V
A
L
D
S
L
I
N
F
E
A
V
K
Y
F
N
N
E
K
Y
L
A
D
K
Y
N
G
S
L
M
N
Y
R
D
S
Q
I
K
V
S
Q
S
L
A
F
L
N
S
G
Q
N
L
I
F
T
T
A
L
T
A
M
M
Y
M
G
C
T
G
V
I
G
G
N
--
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
L
I
D
M
E
T
L
F
K
L
R
-
K
N
E
V
K
I
K
N
A
E
R
P
L---
M
-
L
P
E
N
V
P
Y
-
D
-----
I
T
F
E
N
V
T
F
G
Y
H
P
D
--
R
-
K
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
L
I
N
G
R
D
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
D
T
P
L
F
N
D
T
I
W
E
N
V
-
K
F
G
R
I
D
---
A
T
D
E
E
V
I
T
V
V
E
K
A
Q
L
A
P
L
I
K
K
L
P
Q
G
F
D
T
I
V
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
N
--
F
TS
G
S
R
T
S
V
Y
I
A
H
R
L
R
T
I
A
D
A
D
K
I
I
V
L
D
N
G
R
V
R
E
E
G
K
H
L
E
L
L
A
M
P-
G
S
L
Y
R
E
L
W
T
I
Q
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
77.72
21%
-120
- C2 -
4Q4H
-
?
A:
[2-569]
----------------------------------------------------------------------------------------------------
K
T
L
A
R
Y
L
-
K
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
F
--
S
----
L
-----
V
--
L
-
K
---
T
G
I
----
L
M
L
I
V
A
L
I
G
----
A
V
G
G
I
G
C
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
--
R
--
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
N
L
V
M
M
-
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
-
V
M
A
V
S
I
N
V
K
L
S
--
S
V
L
I
F
L
I
P
P
--
I
V
L
L
F
V
W
------
L
T
----
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
R
K
A
N
E
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
V
L
V
R
N
N
Q
--
M
E
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
-
N
E
K
P
A
I
E
E
A
D
N
A
----
L
-
A
L
P
N
V
E
G
-
S
-----
V
S
F
E
N
V
E
F
R
Y
F
E
N
-
T
D
-
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
-
K
W
G
R
E
D
---
A
T
D
D
E
I
V
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
G
L
K
R
Y
--
T
--
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
77.51
25%
-115
- C2 -
4MRS
12
ATM1_NOVAD
A:
[36-600]
---------------------------------------------------------------------------------------------------------------
R
R
R
V
V
G
A
I
L
M
V
L
L
G
K
A
T
T
L
A
L
P
F
A
Y
K
K
A
V
D
A
M
T
L
G
G
G
A--
Q
----
P
-----
A
--
L
-
T
---
V
A
L
A
F
V
L
A
Y
A
L
G
R
F
S
G
----
V
L
F
D
N
L
R
N
I
V
F
E
R
V
G
Q
D
A
T
R
H
L
A
E
N
V
F
A
R
L
H
K
L
S
L
R
F
H
L
--
A
--
R
R
T
G
E
V
T
K
V
I
E
R
G
T
K
S
I
D
T
M
L
Y
F
-
L
L
F
N
I
A
P
T
V
I
E
L
T
-
A
V
-
I
V
I
F
W
L
N
F
G
L
G
--
L
V
T
A
T
I
L
A
V
I
A
Y
V
W
T
T
R
T
------
I
T
----
E
W
R
T
H
L
R
E
K
M
N
R
L
D
G
Q
A
L
A
R
A
V
D
S
L
L
N
Y
E
T
V
K
Y
F
G
A
E
S
R
E
E
A
R
Y
A
S
A
A
R
A
Y
A
D
A
A
V
K
S
E
N
S
L
G
L
L
N
I
A
Q
A
L
I
V
N
L
L
M
A
G
A
M
A
W
T
V
Y
G
W
S
Q
G
K
--
L
T
V
G
D
L
V
F
V
N
T
Y
L
T
Q
L
F
R
P
L
D
M
L
G
M
V
Y
R
T
I
R
Q
G
L
I
D
M
A
E
M
F
R
L
I
-
D
T
H
I
E
V
A
D
V
P
N
A
----
P
-
A
L
V
V
N
R
P
-
S
-----
V
T
F
D
N
V
V
F
G
Y
D
R
D
--
R
-
E
I
L
H
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
---
E
G
R
I
L
I
D
G
Q
D
I
A
H
V
T
Q
T
S
L
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
N
D
T
I
G
Y
N
I
-
A
Y
G
R
D
G
---
A
S
R
A
E
V
D
A
A
A
K
G
A
A
I
A
D
F
I
A
R
L
P
Q
G
Y
D
T
E
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
I
L
L
F
D
E
A
T
S
A
L
D
T
R
T
E
Q
D
I
L
S
T
M
R
A
V
--
A
--
S
H
R
T
T
I
S
I
A
H
R
L
S
T
I
A
D
S
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
L
D
L
L
R
R
--
D
G
L
Y
A
E
M
W
A
R
Q
A
A
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
75.61
21%
-117
- C2 -
4RY2
-
?
A:
[159-724]
-------------------------------------------------------------------------------------------------------
A
G
F
L
-
K
P
L
K
K
T
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
K
L
--
N
----
D
-----
L
--
H
-
I
---
I
S
A
----
G
F
A
V
I
F
L
L
Q
----
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
--
S
--
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
S
G
-
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
-
I
L
L
Y
I
Q
N
S
S
L
F
--
F
I
S
F
I
I
I
L
L
--
Y
G
I
I
V
T
V
------
F
N
----
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
--
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
-
E
L
A
T
E
K
E
L
----------------
G
-
D
-----
I
E
F
R
N
V
D
F
R
Y
G
L
R
--
K
-
P
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
-
C
L
G
N
E
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
--
E
--
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
G
C
Y
F
K
M
W
K
Q
T
E
N
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
75.18
23%
-100
- C2 -
3B60
2
MSBA_SALTY
A:
[15-580]
-----------------------------------------------------------------------------------------------------
R
L
W
P
T
I
-
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
---
R
S---
V
-----
L
--
L
-
W
---
M
P
L
----
V
V
I
G
L
M
I
L
R
----
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
--
K
--
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
-
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
-
I
M
M
F
Y
Y
S
W
Q
L
S
--
I
I
L
V
V
L
A
P
I
--
V
S
I
A
I
R
V
------
V
S
----
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
--
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
-
D
S
E
Q
E
K
D
E
G
--
K
----
R
-
V
I
D
R
A
T
G
-
D
-----
L
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
-
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
-
A
Y
A
R
T
E
E--
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
--
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.62
28%
-71
- C- -
3B5X
-
MSBA_VIBCH
A:
[47-579]
--------------------------------------------------------------------------------------------------------------------------------------
L
L
K
P
L
L
D
E
G
F
G
N
A
E
---
S
----
N
F
L
R
I
L
P
--
F
-
M
---
I
L
G
----
L
M
F
V
R
G
L
S
G
F
A
S
S
Y
C
L
S
W
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
-----
M
P
V
---
R
F
F
D
--
Q
--
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
S
R
A
L
V
S
I
V
R
E
G
A
S
I
I
G
L
L
T
-
L
M
F
W
N
-
S
W
Q
L
S
--
L
V
L
I
V
V
A
P
V
--
V
A
F
A
I
S
F
------
V
S
----
K
R
F
R
K
I
S
R
N
M
Q
T
A
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
M
R
Q
Q
T
M
K
L
V
S
A
Q
S
I
A
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
A
S
V
D
S
I
R
A
E
--
L
T
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
M
-
D
L
E
T
E
-
R
D
N
G
K
Y
----
E
-
A
E
-
R
V
N
G
-
E
-----
V
D
V
K
D
V
T
F
T
Y
Q
G
K
-
E
K
-
P
A
L
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
---
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
A
E
G
E
---
Y
T
R
E
Q
I
E
Q
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
--
Q
--
K
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
--
D
G
A
Y
A
Q
L
H
R
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
73.90
25%
-80
- C- -
3B5X
-
MSBA_VIBCH
A:
[13-580]
---------------------------------------------------------------------------------------------------
F
K
R
L
W
T
Y
I
-
R
L
Y
K
A
G
L
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
L
L
D
E
G
F
G
N
A
E
---
S
----
N
-----
F
L
-
R
-
I
---
L
P
F
----
M
I
L
G
L
M
F
V
R
----
G
L
S
G
F
A
S
S
Y
C
L
S
W
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
--
Q
--
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
S
R
-
A
L
V
S
I
V
R
E
G
A
S
I
I
G
L
L
-
T
L
M
F
W
N
S
W
Q
L
S
--
L
V
L
I
V
V
A
P
V
--
V
A
F
A
I
S
F
------
V
S
----
K
R
F
R
K
I
S
R
N
M
Q
T
A
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
M
R
Q
Q
T
M
K
L
V
S
A
Q
S
I
A
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
A
S
V
D
S
I
R
A
E
--
L
T
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
M
-
D
L
E
T
E
R
D
N
G
--
K
----
Y
-
E
A
E
R
V
N
G
-
E
-----
V
D
V
K
D
V
T
F
T
Y
Q
G
K
-
E
K
-
P
A
L
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
---
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
-
A
Y
A
A
E
G
E--
Y
T
R
E
Q
I
E
Q
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
--
Q
--
K
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
--
D
G
A
Y
A
Q
L
H
R
I
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
73.29
24%
-113
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[7-572]
---------------------------------------------------------------------------------------------------
A
R
K
L
L
G
L
A
-
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
---
V
DY
S
D
N
-----
L
--
T
-
R
---
L
C
L
----
G
L
S
A
V
F
L
C
G
----
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
--
K
--
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
-
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
-
S
M
M
F
F
V
S
P
N
L
A
--
T
F
V
L
S
V
V
P
P
--
V
S
I
I
A
V
I
------
Y
G
----
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
H
--
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
-
E
R
E
P
K
L
P
F
N
E
G
V
----
I
L
N
E
K
S
F
Q
G
-
A
-----
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
-
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
-
A
Y
G
A
D
D
PSS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.41
31%
-112
- C3 -
4MYC
-
ATM1_YEAST
A:
[250-676]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
Y
Q
F
G
A
S
F
A
A
I
T
F
S
T
M
--
L
L
Y
S
I
F
T
I
K
T
T
A
W
R
T
----
H
F
R
R
D
A
N
K
A
D
N
K
A
A
S
V
A
L
D
S
L
I
N
F
E
A
V
K
Y
F
N
N
E
K
Y
L
A
D
K
Y
N
G
S
L
M
N
Y
R
D
S
Q
I
K
V
S
Q
S
L
A
F
L
N
S
G
Q
N
L
I
F
T
T
A
--
L
T
A
M
M
Y
M
G
C
T
G
V
--
I
G
G
N
--
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
L
I
D
M
E
T
L
F
K
L
R
-
K
N
E
V
K
I
K
N
A
-------
E
-
R
P
-
L
M
L
P
-
E
N
V
P
Y
D
I
T
F
E
N
V
T
F
G
Y
H
P
D
-
R
--
K
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
L
I
N
G
R
D
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
D
T
P
L
F
N
D
T
I
W
E
N
V
-
K
F
G
R
I
D
---
A
T
D
E
E
V
I
T
V
V
E
K
A
Q
L
A
P
L
I
K
K
L
P
Q
G
F
D
T
I
V
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
N
F
T
S
--
G
S
R
T
S
V
Y
I
A
H
R
L
R
T
I
A
D
A
D
K
I
I
V
L
D
N
G
R
V
R
E
E
G
K
H
L
E
L
L
A
M
P-
G
S
L
Y
R
E
L
W
T
I
Q
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
71.35
31%
-110
- C3 -
4MYH
1
ATM1_YEAST
B:
[153-579]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
Y
Q
F
G
AS
F
A
A
I
T
F
S
T
M
--
L
L
Y
S
I
F
T
IKTTAW
R
T
----
H
F
R
R
D
A
N
K
A
D
N
K
A
A
S
V
A
L
D
S
L
I
N
F
E
A
V
K
Y
F
N
N
E
K
Y
L
A
D
K
Y
N
G
S
L
M
N
Y
R
D
S
Q
I
K
V
S
Q
S
L
A
F
L
N
S
G
Q
N
L
I
F
T
T
A
--
L
T
A
M
M
Y
M
G
C
T
G
V
--
I
G
G
N
--
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
L
I
D
M
E
T
L
F
K
L
R
-
K
N
E
V
K
I
K
N
A
-------
E
-
R
P
-
L
M
L
P
-
E
NVPYD
I
T
F
E
N
V
T
F
G
Y
H
P
D
-
R
--
K
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
L
I
N
G
R
D
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
D
T
P
L
F
N
D
T
I
W
E
N
V
-
K
F
G
R
I
D
---
A
T
D
E
E
V
I
T
V
V
E
K
A
Q
L
A
P
L
I
K
K
L
P
Q
G
F
D
T
I
V
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
N
FT
S
--
G
S
R
T
S
V
Y
I
A
H
R
L
R
T
I
A
D
A
D
K
I
I
V
L
D
N
G
R
V
R
E
E
G
K
H
L
E
L
L
A
M
P-
G
S
L
Y
R
E
L
W
T
I
Q
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Fugue
71.19
21%
-102
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
------------------------------------------------------------------------------------------------W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
R
---
S
----
V
-----
L
--
L
-
W
---
M
P
L
----
V
V
I
G
L
M
I
L
R
----
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
--
K
--
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
-
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
-
I
M
M
F
Y
Y
S
W
Q
L
S
--
I
I
L
V
V
L
A
P
I
--
V
S
I
A
I
R
V
------
V
S
----
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
--
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
-
D
S
E
Q
E
K
D
-
E
G
K
R
----
V
-
I
D
-
R
A
T
G
-
D
-----
L
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
-
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
--
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
71.05
31%
-107
- C3 -
4MYH
-
ATM1_YEAST
A:
[153-579]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
Y
Q
F
G
A
S
F
A
A
I
T
F
S
T
M
--
L
L
Y
S
I
F
T
I
K
T
T
A
W
R
T
----
H
F
R
R
D
A
N
K
A
D
N
K
A
A
S
V
A
L
D
S
L
I
N
F
E
A
V
K
Y
F
N
N
E
K
Y
L
A
D
K
Y
N
G
S
L
M
N
Y
R
D
S
Q
I
K
V
S
Q
S
L
A
F
L
N
S
G
Q
N
L
I
F
T
T
A
--
L
T
A
M
M
Y
M
G
C
T
G
V
--
I
G
G
N
--
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
S
V
Y
R
D
L
K
Q
S
L
I
D
M
E
T
L
F
K
L
R
-
K
N
E
V
K
I
K
N
A
-------
E
-
R
P
-
L
M
L
P
-
E
N
V
P
Y
D
I
T
F
E
N
V
T
F
G
Y
H
P
D
-
R
--
K
I
L
K
N
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
L
I
N
G
R
D
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
D
T
P
L
F
N
D
T
I
W
E
N
V
-
K
F
G
R
I
D
---
A
T
D
E
E
V
I
T
V
V
E
K
A
Q
L
A
P
L
I
K
K
L
P
Q
G
F
D
T
I
V
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
N
F
T
S
--
G
S
R
T
S
V
Y
I
A
H
R
L
R
T
I
A
D
A
D
K
I
I
V
L
D
N
G
R
V
R
E
E
G
K
H
L
E
L
L
A
M
P-
G
S
L
Y
R
E
L
W
T
I
Q
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
69.72
24%
-109
- C2 -
4F4C
-
PGP1_CAEEL
A:
[144-702]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
T
V
G
M
----
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
--
T
--
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
-
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
-
I
V
A
F
T
H
S
W
Q
L
T
--
L
V
M
L
A
V
T
P
I
--
Q
A
L
C
G
F
A
------
I
A
----
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
G
S
--
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
L
-
D
R
K
P
V
I
D
S
S
S
K
A
G
---
R
-
K
D
M
K
I
K
G
-
D
-----
I
T
V
E
N
V
H
F
T
Y
P
S
R
P
D
V
-
P
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
-
S
L
G
K
E
G
---
I
T
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
--
A
--
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
--
Q
G
L
Y
Y
D
L
V
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
68.81
25%
-103
- C2 -
4Q9H
-
MDR1A_MOUSE
A:
[758-1273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
I
I
S
----
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
M
L
R
Q
D
V
S
W
F
D
DP
K
--
N
T
T
G
A
L
T
T
R
L
A
N
D
A
A
Q
V
K
G
A
T
G
S
-
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
-
I
I
S
L
I
Y
G
W
Q
L
T
--
L
L
L
L
A
I
V
P
I
--
I
A
I
A
G
V
V
------
E
M
----
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
T
R
E
Q
K
F
E
T
M
Y
A
Q
S
L
Q
I
P
Y
R
N
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
Q
L
--
M
T
F
E
N
V
L
L
V
F
S
A
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
A
P
D
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
-
E
K
T
P
E
I
D
S
Y
S
T
Q
GL--
K
-
P
N
-
M
L
E
G
-
N
-----
V
Q
F
S
G
V
V
F
N
Y
P
T
R
P
S
I
-
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
---
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
S
I
A
E
N
I
-
A
Y
G
D
N
S
R
V
-
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
--
R
--
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
--
K
G
I
Y
F
S
M
V
S
V
Q
A
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Fugue
68.72
27%
-113
- C2 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
----------
F
L
P
T
G
Q
N
Y
T
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
---
M
----
T
-----
V
--
G
-
M
---
W
A
A
----
G
Q
I
T
V
T
C
Y
L
----
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
------------
E
I
S
W
F
D
--
T
--
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
-
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
-
I
V
A
F
T
H
S
W
Q
L
T
--
L
V
M
L
A
V
T
P
I
--
Q
A
L
C
G
F
A
------
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
-
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
-
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
--
G
S
--
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
P
V
I
D
S
S
S
K
A
G
----
R
-
K
D
-
M
K
I
K
G
D
-----
I
T
V
E
N
V
H
F
T
Y
P
S
R
-
P
D
V
P
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
-
S
L
G
K
E
G
---
I
T
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
--
A
--
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
--
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
123
HHSearch
68.61
23%
-114
- C2 -
3WMG
5
?
A:
[30-598]
-------------------------------------------------------------------------------------------------------------------
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
Q
I
E
G
----
E
-----
T
--
W
-
K
---
Y
S
V
----
G
F
V
G
I
G
V
F
E
----
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
--
R
--
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
-
L
G
-
A
V
L
F
N
L
A
Q
C
V
V
G
I
-
I
V
A
F
I
F
A
P
A
L
T
--
G
V
L
I
A
L
S
P
L
--
V
V
L
A
V
V
V
------
Q
M
----
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
--
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
-
D
R
V
P
Q
Y
R
R
P
D
P
G
A
E
V
V
T
-
Q
P
L
V
L
K
Q
-
G
-----
I
V
F
E
N
V
H
F
R
Y
P
T
R
M
N
V
-
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
-
L
Y
G
K
R
D
---
A
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
--
M
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
65.15
23%
-110
- C2 -
4Q9H
-
MDR1A_MOUSE
A:
[115-685]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
I
G
A
G
V
----
L
I
V
A
Y
I
Q
V
S
F
W
C
L
A
A
G
R
Q
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
--
V
--
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
-
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
-
I
I
G
F
T
R
G
W
K
L
T
--
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
------
W
A
----
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
--
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
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P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
-
D
N
K
P
S
I
D
S
F
S
K
S
GH--
K
-
P
D
-
N
I
Q
G
-
N
-----
L
E
F
K
N
I
H
F
S
Y
P
S
R
K
E
V
-
Q
I
L
K
G
L
N
L
K
V
K
S
G
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V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
-
R
Y
G
R
E
D
---
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
--
R
--
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
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Q
G
N
H
D
E
L
M
R
E
--
K
G
I
Y
F
K
L
V
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
63.00
23%
-110
- C2 -
4F4C
2
PGP1_CAEEL
A:
[800-1306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
V
L
A
A
A
Q
----
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
Q
H
I
G
F
F
D
--
S
PQ
N
A
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
-
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
-
G
L
A
F
F
Y
G
W
Q
M
A
--
L
L
I
I
A
I
L
P
I
--
V
A
F
G
Q
Y
L
------
R
G
----
R
R
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K
N
V
K
S
A
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A
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A
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L
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G
C
A
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V
L
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L
L
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T
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A
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R
M
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A
L
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D
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PT
M
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A
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T
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T
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A
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A
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F
A
G
G
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F
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M
L
-
R
K
I
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K
I
D
S
L
S
L
A
G---
E
-
K
K
-
K
L
Y
G
-
K
-----
V
I
F
K
N
V
R
F
A
Y
P
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R
P
E
I
-
E
I
L
K
G
L
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P
G
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A
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G
C
G
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A
L
L
E
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F
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D
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---
G
G
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E
I
K
T
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P
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T
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S
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A
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A
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N
I
-
I
Y
G
L
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V
T
M
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V
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A
A
R
L
A
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G
D
R
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L
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G
G
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R
I
A
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A
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A
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V
R
N
P
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I
L
L
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A
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A
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K
V
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A
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--
R
--
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V
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N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
E
--
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
62.40
22%
-108
- C2 -
4A82
-
Y1866_STAAM
A:
[1-576]
--------------------------------------------------------------------------------------------------
M
I
K
R
Y
L
Q
F
V
-
K
P
Y
K
Y
R
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F
A
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---
L
T
T
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--
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--
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I
A
--
I
G
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----
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F
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F
V
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V
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----
P
P
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F
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Y
L
A
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W
T
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N
K
I
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D
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K
K
L
Y
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H
L
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A
L
S
A
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Y
A
--
N
--
N
Q
V
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Q
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R
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I
N
D
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T
K
D
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G
L
M
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W
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C
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I
I
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A
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F
F
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L
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--
L
A
A
L
F
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Y
I
L
T
V
Y
V
------
F
F
----
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R
L
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L
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A
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P
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Q
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-
R
-----
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N
D
N
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A
-
P
I
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K
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T
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A
F
V
G
M
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G
G
G
K
S
T
L
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N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
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G
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N
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D
F
L
T
G
S
L
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N
Q
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L
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Q
D
N
I
L
F
S
D
T
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N
I
-
L
L
G
R
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---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
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A
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L
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--
Q
G
A
Y
E
H
L
Y
S
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------