@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1354c: (2016-05-01 )
MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEPLVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
Atome Classification :
(38 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......--210.--......220.......230.......240.......250.----......260.......270---.....----...280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380..---.....390.......400.......410.......420.......430.......440....-....450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.....-------..590.......600-.......610.......620.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MCNDTA
T
P
Q
L
E
E
L
V
T
T
V
A
N
Q
L
M
TVDAA
T
S
A
E
V
S
Q
R
V
L
A
Y
L
V
E
Q
LGV
D
V
S
F
L
RHNDR
D
R
R
A
T
R
L
V
AEWPPRLNIPDPDP
L
R
L
I
Y
FADA
D
P
V
F
A
L
C
E
HAKE
P
L
V
FRPEPA
T
E
D
Y
Q
R
L
I
E
EARGVPVTSAAAVPLVSG
E
I
T
T
G
L
L
G
F
I
KFGDRK
W
H
E
A
E
L
N
A
L
M
T
I
A
T
L
F
A
Q
V
Q
A
R
V
A
A
E
A
R
L
R
Y
LADHD
D
L
T
G
L
H
N
R
R
A
L
L
Q
H
L
D
Q
RLAPG--QPG
P
--
V
A
A
L
F
L
D
L
D
R
L
K
A
I
N
D
Y
LGHAA
G
D
Q
F
I
H
V
F
A
Q
RI
G
D
A
L
V
G
----
E
S
L
I
A
R
LGGD
E
F
V
L
I
PAS----PMSA
D
----
A
A
Q
P
L
A
E
R
L
R
D
Q
L
K
D
H
V
AI
G
G
E
V
L
T
R
T
V
S
I
G
VASGTPGQH
T
P
S
D
L
L
R
R
A
D
Q
A
A
L
A
A
KHAGG
D
S
V
A
I
F
T
AD
M
S
VSGELR
N
D
I
E
L
H
L
R
RGIESD
A
L
R
L
V
Y
LPEVDLRTGD---IV
G
T
E
A
L
V
R
WQHPTRGLLAPGC
F
I
P
V
A
E
SIN
L
A
G
E
L
D
R
W
V
L
R
R
A
C
N
E
F
S
E
W
Q
SAGL-GH
D
A
L
-
L
R
I
NVSAG
Q
L
V
T
G
G
F
V
D
F
V
A
D
T
I
G
QHGL
D
A
S
S
V
C
L
E
I
T
E
N
V
V
V
Q
D
L
H
T
A
R
A
T
L
A
R
L
K
EV
G
V
H
I
A
I
DDFGT
G
Y
S
A
I
S
L
L
Q
TLPID
T
L
KI
D
K
T
F
V
R
Q
LGTNTS
D
L
V
I
V
R
G
I
M
T
L
AEG
F
Q
L
D
V
V
AEGV
E
T
E
A
A
A
R
I
L
L
D
Q
R
C
Y
R
A-------QG
F
L
FSRPV
P
G
E
A
M
R
-
H
M
L
S
ARRLPPTCIPATDPALS
76
HHSearch
94.16
36%
-117
- C3 -
4RNH
3
?
A:
[21-449]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
E
R
N
G
Q
W
--
V
V
L
M
F
L
D
L
D
R
F
------
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
S
Q
----
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
P
S
----
Q
G
D
R
E
I
A
L
K
R
A
I
Q
V
A
E
L
I
L
G
R
L
A
R
P
F
T
L
E
G
R
E
F
F
V
T
A
S
I
G
V
A
L
S
P
Q
D
G
A
E
L
S
L
L
M
K
N
A
D
T
A
M
Y
H
A
K
E
M
G
K
N
N
F
Q
F
Y
Q
A
E
M
N
A
R
A
L
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
---
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
--
R
V
P
K
-
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
-------
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
G
-
M
L
Y
A
-----------------
1
PsiBlast_PDB
91.96
36%
-116
- C3 -
4RNH
3
?
A:
[21-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
--
E
R
N
G
Q
W
V
V
L
M
F
L
D
L
D
R
F
------
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
S
Q
----
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
P
S
QGD
R
E
I
A
L
K
----
R
A
I
Q
V
A
E
L
I
L
G
R
L
A
R
P
F
T
L
E
G
R
E
F
F
V
T
A
S
I
G
V
A
L
S
P
Q
D
G
A
E
L
S
L
L
M
K
N
A
D
T
A
M
Y
H
A
K
E
M
G
K
N
N
F
Q
F
Y
Q
A
E
M
N
A
R
A
L
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
---
T
G
D
GRR
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
--
R
V
P
K
-
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
-------
Q
G
Y
L
F
G
R
P
M
P
A
E
-------------------------
2
PsiBlast_PDB
89.13
36%
-114
- C3 -
4RNF
-
?
A:
[1-422]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
--
E
R
N
G
Q
W
V
V
L
M
F
L
D
L
D
-----
N
D
S
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
S
Q
----
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
P
S
QGD
R
E
I
A
L
K
----
R
A
I
Q
V
A
E
L
I
L
G
R
L
A
R
P
F
T
L
E
G
R
E
F
F
V
T
A
S
I
G
V
A
L
S
P
Q
D
G
A
E
L
S
L
L
M
K
N
A
D
T
A
M
Y
H
A
K
E
M
G
K
N
N
F
Q
F
Y
Q
A
E
M
N
A
R
A
L
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
---
T
G
D
GRR
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
--
R
V
P
K
-
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
N
N
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
-------
Q
G
Y
L
F
G
R
P
M
P
A
E
-------------------------
78
HHSearch
74.35
25%
-97
- C2 -
3PJX
9
?
A:
[11-429]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
K
L
R
T
E
S
Y
Q
D
N
L
T
G
L
A
N
R
R
Y
F
E
M
Q
L
N
A
R
V
S
N
P
E-
Q
A
S
S
--
G
Y
L
L
L
L
R
V
K
D
L
A
G
L
N
Q
R
L
G
G
Q
R
T
D
E
L
L
K
A
V
G
E
Q
L
S
R
E
C
A
K
YPET
Q
N
L
V
T
R
I
R
G
G
E
F
A
V
L
A
P
G
----
M
-
T
R
E
----
E
A
L
Q
L
A
Q
S
L
D
S
A
L
S
S
L
Y
A
T
G
A
T
D
V
A
A
V
A
S
I
G
L
A
P
F
A
-
H
G
D
S
P
Q
A
V
L
S
L
G
D
Q
A
L
A
Q
A
E
G
Q
G
E
Q
N
W
A
C
L
D
------
G
D
D
H
H
A
W
H
R
L
L
D
Q
A
L
N
Q
R
R
F
E
L
F
F
Q
P
V
V
A
A
Q
D
T
Q
L--
V
L
H
Y
K
V
L
S
R
L
L
D
E
Q
G
Q
T
I
P
A
G
R
F
L
P
W
L
E
R
F
G
W
T
A
R
L
D
R
L
M
L
E
R
V
L
E
Q
M
A
G
H
--------
E
E
S
-
L
A
L
N
L
S
S
A
T
L
A
D
P
Q
A
L
N
K
V
F
E
I
L
R
A
H
S
N
L
G
A
R
L
T
L
E
I
G
E
E
Q
L
P
E
Q
-
A
V
L
E
Q
L
T
R
R
L
R
E
L
G
F
S
L
S
L
Q
R
F
G
G
R
F
S
M
I
G
N
L
A
R
L
G
L
A
Y
L
K
I
D
G
S
Y
I
R
A
I
D
Q
E
S
D
K
R
L
F
I
E
A
I
Q
R
A
A
H
S
I
D
L
P
L
I
A
E
R
V
E
T
E
G
E
L
S
V
I
R
E
M
G
L
Y
G
V
-------
Q
G
Q
L
F
G
E
P
K
P
W
--------------------------
80
HHSearch
73.22
34%
-119
* C3 *
4HJF
3
?
A:
[70-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
R
L
A
L
E
A
D
L
R
G
A
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
---
L
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
M
L
P
P
D
E
F
L
P
L
I
E
E
M
G
L
M
S
E
L
G
A
H
M
M
H
A
A
A
Q
Q
L
S
T
W
R
A
A
H
P
A
M
G
N
L
T
-
V
S
V
N
L
S
T
G
E
I
D
R
P
G
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
G
T
G
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
-------
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
A
E
-
V
Y
L
N
E
A
Y
V
D
G
-----------
5
PsiBlast_PDB
71.61
39%
-110
- C3 -
2R6O
4
?
A:
[24-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
T
L
D
T
R
L
R
Q
A
L
E
R
N
E
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
---
I
V
G
G
E
A
L
V
R
W
E
D
P
E
R
G
L
V
M
P
S
A
F
I
P
A
A
E
D
T
G
L
I
V
A
L
S
D
W
V
L
E
A
C
C
T
Q
L
R
A
W
Q
Q
Q
G
R
-
A
A
D
D
L
T
L
S
V
N
I
S
T
R
Q
F
E
G
E
H
L
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
-------
Q
G
N
L
M
S
T
P
Q
A
A
D
A
F
A
-
S
L
L
D
R
Q
K
--------------
4
PsiBlast_PDB
71.40
39%
-117
- C3 -
4RNJ
-
?
A:
[1-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
---
T
G
D
GRR
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
--
R
V
P
K
-
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
-------
Q
G
Y
L
F
G
R
P
M
P
A
E
-------------------------
86
HHSearch
71.21
37%
-110
- C3 -
2R6O
4
?
A:
[24-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
T
L
D
T
R
L
R
Q
A
L
E
R
N
E
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
---
I
V
G
G
E
A
L
V
R
W
E
D
P
E
R
G
L
V
M
P
S
A
F
I
P
A
A
E
D
T
G
L
I
V
A
L
S
D
W
V
L
E
A
C
C
T
Q
L
R
A
W
Q
Q
Q
G
R
A
A
D
D
L
T
-
L
S
V
N
I
S
T
R
Q
F
E
G
E
H
L
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
-------
Q
G
N
L
M
S
T
P
Q
A
A
D
A
F
A
-
S
L
L
D
R
Q
K
A
-------------
88
HHSearch
70.80
36%
-119
- C3 -
3S83
2
?
A:
[3-255]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
D
L
R
G
A
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
---
L
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
M
L
P
P
D
E
F
L
P
L
I
E
E
M
G
L
M
S
E
L
G
A
H
M
M
H
A
A
A
Q
Q
L
S
T
W
R
A
A
H
P
A
M
G
N
L
T
-
V
S
V
N
L
S
T
G
E
I
D
R
P
G
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
---
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
-------
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
A
E
-
V
Y
L
N
E
A
---------------
9
PsiBlast_PDB
70.12
38%
-123
- C3 -
4HJF
3
?
A:
[76-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
D
L
R
G
A
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
---
L
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
M
L
P
P
D
E
F
L
P
L
I
E
E
M
G
L
M
S
E
L
G
A
H
M
M
H
A
A
A
Q
Q
L
S
T
W
R
A
A
H
P
-
A
M
G
N
L
T
V
S
V
N
L
S
T
G
E
I
D
R
P
G
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
G
T
G
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
-------
Q
G
F
G
Y
A
-------------------------------
10
PsiBlast_PDB
70.05
38%
-116
- C3 -
3U2E
3
?
A:
[6-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
D
L
R
G
A
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
---
L
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
M
L
P
P
D
E
F
L
P
L
I
E
E
M
G
L
M
S
E
L
G
A
H
M
M
H
A
A
A
Q
Q
L
S
T
W
R
A
A
H
P
-
A
M
G
N
L
T
V
S
V
N
L
S
T
G
E
I
D
R
P
G
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
G
T
G
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
-------
Q
G
F
G
Y
A
-------------------------------
3
PsiBlast_PDB
70.00
39%
-116
- C3 -
4RNI
-
?
A:
[4-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
---
T
G
D
GRR
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
--
R
V
P
K
-
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
-------
Q
G
Y
L
F
G
R
P
M
P
A
E
-------------------------
6
PsiBlast_PDB
69.96
39%
-110
- C3 -
3N3T
4
?
A:
[23-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
T
L
D
T
R
L
R
Q
A
L
E
R
N
E
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
---
I
V
G
G
E
A
L
V
R
W
E
D
P
E
R
G
L
V
M
P
S
A
F
I
P
A
A
E
D
T
G
L
I
V
A
L
S
D
W
V
L
E
A
C
C
T
Q
L
R
A
W
Q
Q
Q
G
R
-
A
A
D
D
L
T
L
S
V
N
I
S
T
R
Q
F
E
G
E
H
L
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
-------
Q
G
N
L
M
S
T
P
Q
A
A
D
A
F
A
-
S
L
L
D
R
Q
K
--------------
83
HHSearch
69.43
37%
-116
- C3 -
4RNI
-
?
A:
[4-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
---
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
--
V
R
V
P
K
-
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
-------
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
G
-
M
L
Y
A
S
----------------
11
PsiBlast_PDB
68.79
38%
-121
- C3 -
3S83
2
?
A:
[3-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
D
L
R
G
A
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
---
L
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
M
L
P
P
D
E
F
L
P
L
I
E
E
M
G
L
M
S
E
L
G
A
H
M
M
H
A
A
A
Q
Q
L
S
T
W
R
A
A
H
P
-
A
M
G
N
L
T
V
S
V
N
L
S
T
G
E
I
D
R
P
G
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
---
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
-------
Q
G
F
G
Y
A
-------------------------------
7
PsiBlast_PDB
67.01
35%
-120
- C3 -
4HU3
-
DOSP_ECOLI
A:
[548-793]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
A
I
S
N
N
Q
L
K
L
V
Y
Q
P
Q
I
F
A
E
T
G
E
---
L
Y
G
I
E
A
L
A
R
W
H
D
P
L
H
G
H
V
P
P
S
R
F
I
P
L
A
E
E
I
G
E
I
E
N
I
G
R
W
V
I
A
E
A
C
R
Q
L
A
E
W
R
S
Q
N
I
--
H
I
P
A
-
L
S
V
N
L
S
A
L
H
F
R
S
N
Q
L
P
N
Q
V
S
D
A
M
H
A
W
G
I
D
G
H
Q
L
T
V
E
I
T
E
S
M
M
M
E
H
D
T
E
I
F
K
R
I
Q
I
L
R
D
M
G
V
G
L
S
V
D
D
F
G
T
G
F
S
G
L
S
R
L
V
S
L
P
V
T
E
I
K
I
D
K
S
F
V
D
R
C
L
T
E
K
R
I
L
A
L
L
E
A
I
T
S
I
G
Q
S
L
N
L
T
V
V
A
E
G
V
E
T
K
E
Q
F
E
M
L
R
K
I
H
C
R
V
I
-------
Q
G
Y
F
F
S
R
P
L
P
A
E
E
I
P
-
G
W
M
S
S
----------------
91
HHSearch
66.97
30%
-113
- C3 -
3SY8
1
?
A:
[143-392]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
A
D
V
V
R
G
L
D
N
G
E
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
---
L
I
G
A
E
V
L
A
R
W
N
H
P
H
L
G
V
L
P
P
S
H
F
L
Y
V
M
E
T
Y
N
L
V
D
K
L
F
W
Q
L
F
S
Q
G
L
A
T
R
R
K
L
A
Q
L
G
---
Q
P
I
N
-
L
A
F
N
V
H
P
S
Q
L
G
S
R
A
L
A
E
N
I
S
A
L
L
T
E
F
H
L
P
P
S
S
V
M
F
E
I
T
E
T
G
L
I
S
A
P
A
S
S
L
E
N
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
Q
I
K
L
D
R
T
F
V
Q
K
M
K
T
Q
P
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
-------
Q
G
Y
L
F
A
R
P
M
P
E
Q
H
F
L
-
D
Y
C
S
G
S
---------------
26
PsiBlast_CBE
66.58
32%
-109
- C3 -
3SY8
1
?
C:
[149-381]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
L
D
N
G
E
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
---
L
I
G
A
E
V
L
A
R
W
N
H
P
H
L
G
V
L
P
P
S
H
F
L
Y
V
M
E
T
Y
N
L
V
D
K
L
F
W
Q
L
F
S
Q
G
L
A
--
T
R
R
K
L
A
Q
L
-
G
Q
P
I
N
-
L
A
F
N
V
H
P
S
Q
L
G
S
R
A
L
A
E
N
I
S
A
L
L
T
E
F
H
L
P
P
S
S
V
M
F
E
I
T
E
T
G
L
I
S
A
P
A
S
S
L
E
N
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
Q
I
K
L
D
R
T
F
V
Q
K
M
K
T
Q
P
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
-------
Q
G
Y
L
F
A
R
P
M
P
---------------------------
21
PsiBlast_CBE
65.06
34%
-111
- C3 -
4LYK
4
YAHA_ECOLI
D:
[34-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
N
H
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
---
L
T
G
C
E
V
L
V
R
W
E
H
P
Q
T
G
I
I
P
P
D
Q
F
I
P
L
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
M
K
Q
T
A
D
I
L
M
P
V
K
H
L
-
L
-
P
D
N
F
H
-
I
G
I
N
V
S
A
G
C
F
L
A
A
G
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
L
V
L
E
L
T
E
R
N
P
I
P
V
T
P
E
A
R
A
I
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
F
I
K
I
D
K
S
F
V
Q
M
A
S
V
D
E
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
-------
Q
G
Y
L
Y
S
P
P
V
P
G
N
K
F
-----------------------
18
PsiBlast_PDB
64.86
31%
-119
- C3 -
4Y9N
1
?
A:
[11-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
---
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
-
G
H
A
G
K
L
-
E
P
G
F
H
-
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
G
H
S
S
L
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
T
L
S
G
H
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
-------
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
-
S
S
L
T
V
Q
---------------
90
HHSearch
63.22
30%
-111
- C3 -
4Q6J
9
?
A:
[8-249]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
E
I
W
D
A
I
R
R
N
S
Y
L
L
Y
Y
Q
P
K
V
D
A
K
T
N
K
---
I
I
G
F
E
G
L
V
R
L
K
T
A
T
-
T
I
L
A
P
I
D
F
F
D
D
I
V
L
L
N
A
T
R
E
M
Q
D
F
V
A
E
T
A
I
K
Q
I
N
Q
L
G
------
G
R
F
S
-
I
S
I
N
I
P
A
H
Y
V
A
S
S
T
Y
M
T
F
L
H
D
Y
V
K
E
H
L
K
Y
P
E
C
L
E
I
E
I
I
E
R
---
T
E
L
A
I
A
D
K
N
L
R
K
I
K
D
L
G
V
K
V
S
M
D
D
F
G
K
G
Y
S
S
L
A
Y
L
R
S
L
P
I
D
I
V
K
T
D
M
S
F
I
A
L
L
K
T
D
R
K
Q
Q
I
I
I
R
A
I
V
N
L
C
H
D
L
G
G
K
V
V
T
E
G
V
E
D
M
E
Q
V
E
K
L
R
E
M
K
V
D
Y
F
-------
Q
G
Y
Y
F
S
R
P
L
P
M
E
E
I
K
-
Q
K
Y
------------------
28
PsiBlast_CBE
62.68
31%
-108
- C3 -
4Y9P
5
?
B:
[11-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
---
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
-
G
H
A
G
K
L
-
E
P
G
F
H
-
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
-----
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
T
L
S
G
H
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
-------
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
-
S
S
L
T
V
Q
---------------
20
PsiBlast_PDB
61.76
31%
-116
- C3 -
4Y9Q
4
?
A:
[11-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
---
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
-
G
H
A
G
K
L
-
E
P
G
F
H
-
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
G
H
S
S
L
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
T
L
S
G
H
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
-------
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
-
S
S
L
T
V
Q
---------------
84
HHSearch
61.46
31%
-99
- C3 -
4KIE
5
YAHA_ECOLI
A:
[11-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
V
T
P
E
A
I
S
L
A
L
E
N
H
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
---
L
T
G
C
E
V
L
V
R
W
E
H
P
Q
T
G
I
I
P
P
D
Q
F
I
P
L
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
M
K
Q
T
A
D
I
L
M
P
V
K
H
L
L
--
P
D
N
F
H
-
I
G
I
N
V
S
A
G
C
F
L
A
A
G
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
L
V
L
E
L
T
E
R
N
P
I
P
V
T
P
E
A
R
A
I
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
F
I
K
I
D
K
S
F
V
Q
M
A
S
V
D
E
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
-------
Q
G
Y
L
Y
S
P
P
V
P
G
N
K
F
I
S
E
W
V
M
-----------------
19
PsiBlast_PDB
59.97
31%
-104
- C3 -
4Y9P
5
?
A:
[11-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
---
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
-
G
H
A
G
K
L
-
E
P
G
F
H
-
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
--------
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
T
L
S
G
H
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
-------
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
-
S
S
L
T
V
Q
---------------
12
PsiBlast_PDB
59.04
34%
-103
- C3 -
4KIE
5
YAHA_ECOLI
A:
[23-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
N
H
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
---
L
T
G
C
E
V
L
V
R
W
E
H
P
Q
T
G
I
I
P
P
D
Q
F
I
P
L
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
M
K
Q
T
A
D
I
L
M
P
V
K
H
L
-
L
-
P
D
N
F
H
-
I
G
I
N
V
S
A
G
C
F
L
A
A
G
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
L
V
L
E
L
T
E
R
N
P
I
P
V
T
P
E
A
R
A
I
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
F
I
K
I
D
K
S
F
V
Q
M
A
S
V
D
E
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
-------
Q
G
Y
L
Y
S
P
P
V
P
G
N
K
F
-----------------------
24
PsiBlast_CBE
58.44
34%
-110
- C3 -
4LJ3
5
YAHA_ECOLI
B:
[34-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
N
H
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
---
L
T
G
C
E
V
L
V
R
W
E
H
P
Q
T
G
I
I
P
P
D
Q
F
I
P
L
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
M
K
Q
T
A
D
I
L
M
P
V
K
H
L
-
L
-
P
D
N
F
H
-
I
G
I
N
V
S
A
G
C
F
L
A
A
G
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
L
V
L
E
L
T
E
R
N
P
I
P
V
T
P
E
A
R
A
I
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
F
I
K
I
D
K
S
F
V
Q
M
A
S
V
D
E
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
-------
Q
G
Y
L
Y
S
P
P
V
P
G
N
K
F
-----------------------
13
PsiBlast_PDB
57.14
34%
-105
- C3 -
4LJ3
5
YAHA_ECOLI
A:
[34-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
N
H
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
---
L
T
G
C
E
V
L
V
R
W
E
H
P
Q
T
G
I
I
P
P
D
Q
F
I
P
L
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
M
K
Q
T
A
D
I
L
M
P
V
K
H
L
-
L
-
P
D
N
F
H
-
I
G
I
N
V
S
A
G
C
F
L
A
A
G
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
L
V
L
E
L
T
E
R
N
P
I
P
V
T
P
E
A
R
A
I
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
F
I
K
I
D
K
S
F
V
Q
M
A
S
V
D
E
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
-------
Q
G
Y
L
Y
S
P
P
V
P
G
N
K
F
-----------------------
47
PsiBlast_CBE
37.69
35%
-80
- C3 -
3GFX
2
?
A:
[260-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
-------
L
E
E
W
C
W
L
Q
S
V
GIRLF
Q
G
F
L
F
S
R
P
C
----------------------------
41
PsiBlast_CBE
33.98
35%
-77
- C3 -
3GG0
3
?
A:
[260-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
-------
L
E
E
W
C
W
L
Q
S
V
GIRLF
Q
G
F
L
F
S
R
P
C
----------------------------
42
PsiBlast_CBE
32.81
35%
-87
- C3 -
3GFZ
3
?
B:
[260-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
-------
L
E
E
W
C
W
L
Q
S
V
GIRLF
Q
G
F
L
F
S
R
P
C
----------------------------
43
PsiBlast_CBE
32.40
35%
-80
- C3 -
3GFZ
3
?
A:
[260-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
-------
L
E
E
W
C
W
L
Q
S
V
GIRLF
Q
G
F
L
F
S
R
P
C
----------------------------
46
PsiBlast_CBE
32.35
35%
-84
- C3 -
3GFX
2
?
B:
[260-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
-------
L
E
E
W
C
W
L
Q
S
V
GIRLF
Q
G
F
L
F
S
R
P
C
----------------------------
40
PsiBlast_CBE
31.64
35%
-88
- C3 -
3GG0
3
?
B:
[260-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
-------
L
E
E
W
C
W
L
Q
S
V
GIRLF
Q
G
F
L
F
S
R
P
C
----------------------------
39
PsiBlast_CBE
31.50
35%
-80
- C3 -
3GG1
3
?
A:
[260-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
-------
L
E
E
W
C
W
L
Q
S
V
GIRLF
Q
G
F
L
F
S
R
P
C
----------------------------
38
PsiBlast_CBE
29.31
35%
-83
- C3 -
3GG1
3
?
B:
[260-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
-------
L
E
E
W
C
W
L
Q
S
V
GIRLF
Q
G
F
L
F
S
R
P
C
----------------------------
45
PsiBlast_CBE
25.13
35%
-68
- C3 -
3GFY
1
?
A:
[260-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
----------
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
-----------
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
-------
L
E
E
W
C
W
L
Q
S
V
GIRLF
Q
G
F
L
F
S
R
P
C
----------------------------
44
PsiBlast_CBE
23.19
35%
-69
- C3 -
3GFY
1
?
B:
[260-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
Q
V
L
I
E
V
-------
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
-------------
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
-------
L
E
E
W
C
W
L
Q
S
V
GIRLF
Q
G
F
L
F
S
R
P
C
----------------------------