@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1373: (2016-05-01 )
MNSEHPMTDRVVYRSLMADNLRWDALQLRDGDIIISAPSKSGLTWTQRLVSLLVFDGPDLPGPLSTVSPWLDQTIRPIEEVVATLDAQQHRRFIKTHTPLDGLVLDDRVSYICVGRDPRDAAVSMLYQSANMNEDRMRILHEAVVPFHERIAPPFAELGHARSPTEEFRDWMEGPNQPPPGIGFTHLKGIGTLANILHQLGTVWVRRHLPNVALFHYADYQADLAGELLRPARVLGIAATRDRARDLAQYATLDAMRSRASEIAPNTTDGIWHSDERFFRRGGSGDWQQFFTEAEHLRYYHRINQLAPPDLLAWAHEGRRGYDPAN
Atome Classification :
(20 SA)
--.........10--........--20-.--...---.....30........40........50..------------------....-----..--------60--.---..----....----..70....----------------------..---..-----80.......--.90........100.-----.---.---....110.......120.......130.......140.......150.......160--.......170.......180.......190.......200....-...210.......220.......230.......240.......250.....----..260...-....----270....-....280.......290.......300.....---..310.......320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MNSEHP
M
T
D
R
V
--
V
Y
R
S
L
M
AD--N--L--R
W
D
---
A
L
Q
LRDG
D
I
I
I
SAPSKSG
L
T
W
T
Q
R
L
V
S
L
L
------------------VFDG-----PD--------L---P---GP----
L
S
T
V
----
S
P
W
L
D
Q
T
I
----------------------
R
P
---
I
E
-----
E
V
V
A
T
L
D
A
Q
--
Q
H
R
R
F
I
K
THTPLD
G
L
-----
V
---L---DDR
V
S
Y
I
C
VGRD
P
R
D
A
A
V
S
M
L
Y
QSANM
N
E
D
R
M
R
I
L
H
E
A
V
V
P
F
H
E
RIA
P
P
F
A
E
LGHAR--S
P
T
E
E
F
R
D
W
MEGPNQPPPGI
G
F
T
H
L
K
G
I
G
T
L
A
N
I
L
H
Q
L
G
T
V
W
V
R
-
R
HLPNV
A
L
F
HYAD
Y
Q
A
D
L
A
G
E
L
LR
P
A
R
V
L
G
I
AA
T
R
D
R
A
R
D
L
A
Q
Y
A
T
L
D
A
M
R
----
S
R
A
S
EIAP-NTTD----G-IWHS
D
-
E
R
F
F
RRGGS
G
D
W
Q
Q
F
F
T
E
A
E
H
L
R
Y
Y
H
R
I
NQLA---
P
P
D
L
L
A
W
A
HEGRRGYDPAN
5
PsiBlast_PDB
91.03
25%
-83
- C3 -
1FML
3
?
A:
[44-325]
------------
M
--
V
Y
R
P
Y
L
K
D
--
A
--
A
--
N
I
Y
---
N
M
P
L
R
P
T
D
V
F
V
A
S
Y
Q
R
S
G
T
T
M
T
Q
E
L
V
W
L
I
E
N
DLNFEAAKTY
M
S
L
R
Y
I
Y
L
D
G
FMIYD
P
E
K
Q
E
E
Y
N
D
I
L
---
P
---
N
P
ENLD
M
E
R
Y
----
L
G
L
L
E
Y
S
S
----------------------
R
P
---
G
S
-----
S
L
L
A
A
V
P
P
T
--
E
-
K
R
F
V
K
T
H
L
P
L
S
L
M
PP---
N
---
M
---
L
D
T
V
K
M
V
Y
L
A
R
D
P
R
D
V
A
V
S
---------------------
S
F
H
H
------
A
R
L
L
Y
L
L
--
N
K
Q
S
N
F
K
D
F
W
E
-----------
M
F
H
R
G
L
Y
T
L
T
P
Y
F
E
H
V
K
E
A
W
A
K
-
R
H
D
P
N
M
L
F
L
F
Y
E
D
Y
L
K
D
L
P
G
C
I
A
R
I
A
D
F
L
G
K
K
L
S
E
E
Q
I
Q
R
L
C
E
H
L
N
F
E
K
F
K
----
N
N
G
---
A
V
-
N
M
E
D
Y
R
E
I
G
-
I
L
A
D
G
-
E
H
F
I
R
K
G
K
A
G
C
W
R
D
Y
F
D
E
------------------------------------
21
HHSearch
89.12
26%
-76
- C3 -
1FMJ
6
?
A:
[54-339]
----------------------------
A
--
N
I
Y
---
N
M
P
L
R
P
T
D
V
F
V
A
S
Y
Q
R
S
G
T
T
M
T
Q
E
L
V
W
L
I
------------------
E
N
D
L
-----
N
F
--------
E
---
A
AK-
T
Y
----
M
S
L
R
----
Y
I
Y
L
D
G
F
M
IYDPEK
Q
E
E
Y
N
D
I
LPNPENLD
M
E
R
Y
L
G
L
L
E
Y
S
S
R
P
G
S
S
L
L
A
A
V
PP
T
E
K
R
F
V
K
T
H
L
P
L
S
L
M
-----
P
---
P
NM-
L
D
T
V
K
M
V
Y
L
A
R
D
P
R
D
V
A
V
S
S
F
H
H
A
R
L
L
Y
L
L
N
-----------------------
K
Q
S
--
N
F
K
D
F
W
E
M
F
H
R
G
L
Y
---------------
T
L
T
P
Y
F
E
H
V
K
E
A
W
A
K
-
R
H
D
P
N
M
L
F
L
F
Y
E
D
Y
L
K
D
L
P
G
C
I
A
R
I
A
D
F
L
G
K
K
L
S
E
E
Q
I
Q
R
L
C
E
H
L
N
F
E
K
F
K
----
N
N
G
A
V
N
M
E
D
Y
R
E
I
----
G
-
I
L
A
D
G
-
E
H
F
I
R
K
G
K
A
G
C
W
R
D
Y
F
D
E
E
M
T
K
Q
A
E
K
W
I
K
D
N
L
----------------------
4
PsiBlast_PDB
88.96
25%
-79
- C3 -
1FMJ
6
?
A:
[44-325]
------------
M
--
V
Y
R
P
Y
L
K
D
--
A
--
A
--
N
I
Y
---
N
M
P
L
R
P
T
D
V
F
V
A
S
Y
Q
R
S
G
T
T
M
T
Q
E
L
V
W
L
I
E
N
DLNFEAAKTY
M
S
L
R
Y
I
Y
L
D
G
FMIYD
P
E
K
Q
E
E
Y
N
D
I
L
---
P
---
N
P
ENLD
M
E
R
Y
----
L
G
L
L
E
Y
S
S
----------------------
R
P
---
G
S
-----
S
L
L
A
A
V
P
P
T
--
E
-
K
R
F
V
K
T
H
L
P
L
S
L
M
PP---
N
---
M
---
L
D
T
V
K
M
V
Y
L
A
R
D
P
R
D
V
A
V
S
---------------------
S
F
H
H
------
A
R
L
L
Y
L
L
--
N
K
Q
S
N
F
K
D
F
W
E
-----------
M
F
H
R
G
L
Y
T
L
T
P
Y
F
E
H
V
K
E
A
W
A
K
-
R
H
D
P
N
M
L
F
L
F
Y
E
D
Y
L
K
D
L
P
G
C
I
A
R
I
A
D
F
L
G
K
K
L
S
E
E
Q
I
Q
R
L
C
E
H
L
N
F
E
K
F
K
----
N
N
G
---
A
V
-
N
M
E
D
YREI
G
-
I
L
A
D
G
-
E
H
F
I
R
K
G
K
A
G
C
W
R
D
Y
F
D
E
------------------------------------
2
PsiBlast_PDB
88.87
25%
-80
- C3 -
1X8K
4
?
A:
[44-325]
------------
M
--
V
Y
R
P
Y
L
K
D
--
A
--
A
--
N
I
Y
---
N
M
P
L
R
P
T
D
V
F
V
A
S
Y
Q
R
S
G
T
T
M
T
Q
E
L
V
W
L
I
E
N
DLNFEAAKTY
M
S
L
R
Y
I
Y
L
D
G
FMIYD
P
E
KQEEYNDI
L
---
P
---
N
P
ENLD
M
E
R
Y
----
L
G
L
L
E
Y
S
S
----------------------
R
P
---
G
S
-----
S
L
L
A
A
V
P
P
T
--
E
-
K
R
F
V
K
T
H
L
P
L
S
L
M
PP---
N
---
M
---
L
D
T
V
K
M
V
Y
L
A
R
D
P
R
D
V
A
V
S
---------------------
S
F
H
H
------
A
R
L
L
Y
L
L
--
N
K
Q
S
N
F
K
D
F
W
E
-----------
M
F
H
R
G
L
Y
T
L
T
P
Y
F
E
H
V
K
E
A
W
A
K
-
R
H
D
P
N
M
L
F
L
F
Y
E
D
Y
L
K
D
L
P
G
S
I
A
R
I
A
D
F
L
G
K
K
L
S
E
E
Q
I
Q
R
L
S
E
H
L
N
F
E
K
F
K
----
N
N
G
---
A
V
-
N
M
E
D
Y
R
E
I
G
-
I
L
A
D
G
-
E
H
F
I
R
K
G
K
A
G
C
W
R
D
Y
F
D
E
------------------------------------
1
PsiBlast_PDB
88.81
25%
-79
- C3 -
1X8J
3
?
A:
[44-325]
------------
M
--
V
Y
R
P
Y
L
K
D
--
A
--
A
--
N
I
Y
---
N
M
P
L
R
P
T
D
V
F
V
A
S
Y
Q
R
S
G
T
T
M
T
Q
E
L
V
W
L
I
E
N
DLNFEAAKTY
M
S
L
R
Y
I
Y
L
D
G
FMIYD
P
E
K
Q
E
E
Y
N
DI
L
---
P
---
N
P
ENLD
M
E
R
Y
----
L
G
L
L
E
Y
S
S
----------------------
R
P
---
G
S
-----
S
L
L
A
A
V
P
P
T
--
E
-
K
R
F
V
K
T
H
L
P
L
S
L
M
PP---
N
---
M
---
L
D
T
V
K
M
V
Y
L
A
R
D
P
R
D
V
A
V
S
---------------------
S
F
H
H
------
A
R
L
L
Y
L
L
--
N
K
Q
S
N
F
K
D
F
W
E
-----------
M
F
H
R
G
L
Y
T
L
T
P
Y
F
E
H
V
K
E
A
W
A
K
-
R
H
D
P
N
M
L
F
L
F
Y
E
D
Y
L
K
D
L
P
G
S
I
A
R
I
A
D
F
L
G
K
K
L
S
E
E
Q
I
Q
R
L
S
E
H
L
N
F
E
K
F
K
----
N
N
G
---
A
V
-
N
M
E
D
Y
R
E
I
G
-
I
L
A
D
G
-
E
H
F
I
R
K
G
K
A
G
C
W
R
D
Y
F
D
E
------------------------------------
3
PsiBlast_PDB
88.08
25%
-82
- C3 -
1X8L
4
?
A:
[44-325]
------------
M
--
V
Y
R
P
Y
L
K
D
--
A
--
A
--
N
I
Y
---
N
M
P
L
R
P
T
D
V
F
V
A
S
Y
Q
R
S
G
T
T
M
T
Q
E
L
V
W
L
I
E
N
DLNFEAAKTY
M
S
L
R
Y
I
Y
L
D
G
FMIYD
P
E
K
Q
E
E
Y
N
D
I
L
---
P
---
N
P
ENLD
M
E
R
Y
----
L
G
L
L
E
Y
S
S
----------------------
R
P
---
G
S
-----
S
L
L
A
A
V
P
P
T
--
E
-
K
R
F
V
K
T
H
L
P
L
S
L
M
PP---
N
---
M
---
L
D
T
V
K
M
V
Y
L
A
R
D
P
R
D
V
A
V
S
---------------------
S
F
H
H
------
A
R
L
L
Y
L
L
--
N
K
Q
S
N
F
K
D
F
W
E
-----------
M
F
H
R
G
L
Y
T
L
T
P
Y
F
E
H
V
K
E
A
W
A
K
-
R
H
D
P
N
M
L
F
L
F
Y
E
D
Y
L
K
D
L
P
G
S
I
A
R
I
A
D
F
L
G
K
K
L
S
E
E
Q
I
Q
R
L
S
E
H
L
N
F
E
K
F
K
----
N
N
G
---
A
V
-
N
M
E
D
Y
R
E
I
G
-
I
L
A
D
G
-
E
H
F
I
R
K
G
K
A
G
C
W
R
D
Y
F
D
E
------------------------------------
11
PsiBlast_PDB
84.11
24%
-67
- C3 -
4JVL
6
ST1E1_HUMAN
A:
[2-270]
---
N
S
E
L
D
Y
Y
E
K
F
EE
V
H
G
I
L
M
Y
K
--
D
--
F
V
K
Y
W
D
N
V
E
A
F
Q
A
R
P
D
D
L
V
I
A
T
Y
P
K
S
G
T
T
W
V
S
E
I
V
Y
M
I
------------------
Y
K
E
G
------
D
--------
V
---
E
---
K
C
----
K
E
D
V
I
F
N
R
I
P
F
L
E
C
R
K
----------------------
E
N
---
L
M
-----
N
G
V
K
Q
L
D
E
M
--
N
S
P
R
I
V
K
T
H
L
P
P
E
L
L
P
A
S
F
W
E
---
K
---
D
C
K
I
I
Y
L
C
--
R
N
A
K
D
V
A
V
S
F
Y
Y
-------------------
F
F
L
M
V
A
------
G
H
P
N
PG
S
F
P
E
F
V
E
K
F
M
Q
G
--
Q
V
P
Y
G
S
W
Y
K
H
V
K
-------------
S
W
W
E
K
-
G
K
S
P
R
V
L
F
L
F
Y
E
D
L
K
E
D
I
R
K
E
V
I
K
L
I
H
F
L
E
R
K
P
S
E
E
L
V
D
R
I
I
H
H
T
S
F
Q
E
M
K
----
N
N
P
S
T
N
Y
T
-
T
L
P
D
----
E
-
I
M
N
Q
K
L
S
P
F
M
R
K
G
I
T
G
D
W
K
N
H
F
T
E
A
-----------------------------------
10
PsiBlast_PDB
83.25
24%
-69
- C3 -
1HY3
1
ST1E1_HUMAN
A:
[2-270]
---
N
S
E
L
D
Y
Y
E
K
F
EE
V
H
G
I
L
M
Y
K
--
D
--
F
VK
Y
W
D
N
V
E
A
F
Q
A
R
P
D
D
L
V
I
A
T
Y
P
K
S
G
T
T
W
V
S
E
I
V
Y
M
I
------------------
Y
K
E
G
------
D
--------
V
---
E
---
K
C
----
K
E
D
V
I
F
N
R
I
P
F
L
E
C
R
K
----------------------
E
N
---
L
M
-----
N
G
V
K
Q
L
D
E
M
--
N
S
P
R
I
V
K
T
H
L
P
P
E
L
L
P
A
S
F
W
E
---
K
---
D
C
K
I
I
Y
L
C
--
R
N
A
K
D
V
A
V
S
F
Y
Y
-------------------
F
F
L
M
V
A
------
G
H
P
N
PG
S
F
P
E
F
V
E
K
F
M
Q
G
--
Q
V
P
Y
G
S
W
Y
K
H
V
K
-------------
S
W
W
E
K
-
G
K
S
P
R
V
L
F
L
F
Y
E
D
L
K
E
D
I
R
K
E
V
I
K
L
I
H
F
L
E
R
K
P
S
E
E
L
V
D
R
I
I
H
H
T
S
F
Q
E
M
K
----
N
N
P
S
T
N
Y
T
-
T
L
P
D
----
E
-
I
M
N
Q
K
--
P
F
M
R
K
G
I
T
G
D
W
K
N
H
F
T
E
A
-----------------------------------
12
PsiBlast_PDB
83.22
24%
-66
- C3 -
4JVM
5
ST1E1_HUMAN
A:
[2-270]
---
N
S
E
L
D
Y
Y
E
K
F
EE
V
H
G
I
L
M
Y
K
--
D
--
F
V
K
Y
W
D
N
V
E
A
F
Q
A
R
P
D
D
L
V
I
A
T
Y
P
K
S
G
T
T
W
V
S
E
I
V
Y
M
I
------------------
Y
K
E
G
------
D
--------
V
---
E
---
K
C
----
K
E
D
V
I
F
N
R
I
P
F
L
E
C
R
K
----------------------
E
N
---
L
M
-----
N
G
V
K
Q
L
D
E
M
--
N
S
P
R
I
V
K
T
H
L
P
P
E
L
L
P
A
S
F
W
E
---
K
---
D
C
K
I
I
Y
L
C
--
R
N
A
K
D
V
A
V
S
F
Y
Y
-------------------
F
F
L
M
V
A
------
G
H
P
N
PG
S
F
P
E
F
V
E
K
F
M
Q
G
--
Q
V
P
Y
G
S
W
Y
K
H
V
K
-------------
S
W
W
E
K
-
G
K
S
P
R
V
L
F
L
F
Y
E
D
L
K
E
D
I
R
K
E
V
I
K
L
I
H
F
L
E
R
K
P
S
E
E
L
V
D
R
I
I
H
H
T
S
F
Q
E
M
K
----
N
N
P
S
T
N
Y
T
-
T
L
P
D
----
E
-
I
M
N
Q
K
L
S
P
F
M
R
K
G
I
T
G
D
W
K
N
H
F
T
E
A
-----------------------------------
14
PsiBlast_PDB
83.12
24%
-65
- C3 -
1G3M
6
ST1E1_HUMAN
A:
[3-270]
----
S
E
L
D
Y
Y
E
K
F
EE
V
H
G
I
L
M
Y
K
--
D
--
F
V
K
Y
W
D
N
V
E
A
F
Q
A
R
P
D
D
L
V
I
A
T
Y
P
K
S
G
T
T
W
V
S
E
I
V
Y
M
I
------------------
Y
K
E
G
------
D
--------
V
---
E
---
K
C
----
K
E
D
V
I
F
N
R
I
P
F
L
E
C
R
K
----------------------
E
N
---
L
M
-----
N
G
V
K
Q
L
D
E
M
--
N
S
P
R
I
V
K
T
H
L
P
P
E
L
L
P
A
S
F
W
E
---
K
---
D
C
K
I
I
Y
L
C
--
R
N
A
K
D
V
A
V
S
F
Y
Y
-------------------
F
F
L
M
V
A
------
G
H
P
N
PG
S
F
P
E
F
V
E
K
F
M
Q
G
--
Q
V
P
Y
G
S
W
Y
K
H
V
K
-------------
S
W
W
E
K
-
G
K
S
P
R
V
L
F
L
F
Y
E
D
L
K
E
D
I
R
K
E
V
I
K
L
I
H
F
L
E
R
K
P
S
E
E
L
V
D
R
I
I
H
H
T
S
F
Q
E
M
K
----
N
N
P
S
T
N
Y
T
-
T
L
P
D
----
E
-
I
M
N
Q
K
L
S
P
F
M
R
K
G
I
T
G
D
W
K
N
H
F
T
V
A
-----------------------------------
22
HHSearch
82.89
20%
-70
- C3 -
1AQU
2
ST1E1_MOUSE
A:
[16-286]
--------
E
F
R
G
V
--
L
M
D
K
R
F
T
K
--
Y
--
W
E
-
D
V
E
---
M
F
L
A
R
P
D
D
L
V
I
A
T
Y
P
K
S
G
T
T
W
I
S
E
V
V
Y
M
I
------------------
Y
K
E
G
-----------------------
D
A
----
I
F
N
R
----
I
P
Y
L
E
C
R
N
----------------------
E
D
---
L
I
-----
N
G
I
K
Q
L
K
E
K
--
E
S
P
R
I
V
K
T
H
L
P
P
K
L
L
-----
P
---
A
S
F
W
E
K
N
C
K
M
I
Y
L
C
R
N
A
K
D
V
A
V
S
Y
Y
Y
F
L
L
M
I
T
S
Y
P
-----------------------
N
P
K
--
S
F
S
E
F
V
E
K
F
M
Q
G
Q
V
---------------
P
Y
G
S
W
Y
D
H
V
K
A
W
W
E
K
-
S
K
N
S
R
V
L
F
M
F
Y
E
D
M
K
E
D
I
R
R
E
V
V
K
L
I
E
F
L
E
R
K
P
S
A
E
L
V
D
R
I
I
Q
H
T
S
F
Q
E
M
K
----
N
N
P
S
T
N
Y
T
-
M
M
P
E
----
E
M
M
N
Q
K
V
-
S
P
F
M
R
K
G
I
I
G
D
W
K
N
H
F
P
E
A
L
R
E
R
F
D
E
H
Y
K
Q
Q
M
----------------------
9
PsiBlast_PDB
82.23
25%
-70
- C3 -
1Q22
3
ST2B1_HUMAN
A:
[32-276]
------------------
S
L
E
S
I
--
S
--
L
--
A
E
N
---
T
Q
D
V
R
D
D
D
I
F
I
I
T
Y
P
K
S
G
T
T
W
M
I
E
I
I
C
L
I
------------------
L
K
E
G
D----
P
S
--------
W
I
R
-
S
---
V
P
----
I
W
E
R
----
A
P
W
C
E
T
I
V
----------------------
G
A
---
F
----------
S
L
P
D
-----
P
R
L
M
S
S
H
L
P
I
Q
I
F
-----
T
KAF
F
---
S
S
K
A
K
V
I
Y
M
G
R
N
P
R
D
V
V
V
S
L
Y
H
Y
S
--------------------
K
I
A
---
G
Q
L
K
D
P
G
--
T
P
D
Q
F
L
R
D
F
L
K
G
E
V
Q
--
F
G
S
W
F
D
H
I
K
G
--------------
W
L
R
M
K
G
K
D
N
F
L
F
I
T
Y
E
E
L
Q
Q
D
L
Q
G
S
V
E
R
I
C
G
F
L
G
R
P
L
G
K
E
A
L
G
S
V
V
A
H
S
T
F
S
A
M
K
A
NTM
S
N
Y
T
L
L
P
P
-
S
L
L
D
--------
H
R
R
-
G
A
F
L
R
K
G
V
C
G
D
W
K
N
H
F
T
V
A
Q
----------------------------------
6
PsiBlast_PDB
81.90
25%
-68
- C3 -
1Q1Q
4
ST2B1_HUMAN
A:
[30-274]
------------------
S
L
E
S
I
--
S
--
L
--
A
E
N
---
T
Q
D
V
R
D
D
D
I
F
I
I
T
Y
P
K
S
G
T
T
W
M
I
E
I
I
C
L
I
------------------
L
K
E
G
D----
P
S
--------
W
I
R
-
S
---
V
P
----
I
W
E
R
----
A
P
W
C
E
T
I
V
----------------------
G
A
----------------------
S
P
R
L
M
S
S
H
L
P
I
Q
I
F
-----
T
K
A
F
F
---
S
S
K
A
K
V
I
Y
M
G
R
N
P
R
D
V
V
V
S
L
Y
H
Y
S
--------------------
K
I
A
---
G
Q
L
K
D
P
G
--
T
P
D
Q
F
L
R
D
F
L
K
G
E
V
Q
--
F
G
S
W
F
D
H
I
K
G
--------------
W
L
R
M
K
G
K
D
N
F
L
F
I
T
Y
E
E
L
Q
Q
D
L
Q
G
S
V
E
R
I
C
G
F
L
G
R
P
L
G
K
E
A
L
G
S
V
V
A
H
S
T
F
S
A
M
K
A
NTM
S
N
Y
T
L
L
P
P
-
S
L
L
D
--------
H
R
R
-
G
A
F
L
R
K
G
V
C
G
D
W
K
N
H
F
T
V
A
Q
----------------------------------
13
PsiBlast_PDB
81.80
24%
-65
- C3 -
4JVN
3
ST1E1_HUMAN
A:
[3-270]
----
S
E
L
D
Y
Y
E
K
F
E
E
V
H
G
I
L
M
Y
K
--
D
--
F
V
K
Y
W
D
N
V
E
A
F
Q
A
R
P
D
D
L
V
I
A
T
Y
P
K
S
G
T
T
W
V
S
E
I
V
Y
M
I
------------------
Y
K
E
G
------
D
--------
V
---
E
---
K
C
----
K
E
D
V
I
F
N
R
I
P
F
L
E
C
R
K
----------------------
E
N
---
L
M
-----
N
G
V
K
Q
L
D
E
M
--
N
S
P
R
I
V
K
T
H
L
P
P
E
L
L
P
A
S
F
W
E
---
K
---
D
C
K
I
I
Y
L
C
--
R
N
A
K
D
V
A
V
S
F
Y
Y
-------------------
F
F
L
M
V
A
------
G
H
P
N
PG
S
F
P
E
F
V
E
K
F
M
Q
G
--
Q
V
P
Y
G
S
W
Y
K
H
V
K
-------------
S
W
W
E
K
-
G
K
S
P
R
V
L
F
L
F
Y
E
D
L
K
E
D
I
R
K
E
V
I
K
L
I
H
F
L
E
R
K
P
S
E
E
L
V
D
R
I
I
H
H
T
S
F
Q
E
M
K
----
N
N
P
S
T
N
Y
T
-
T
L
P
D
----
E
-
I
M
N
Q
K
L
S
P
F
M
R
K
G
I
T
G
D
W
K
N
H
F
T
E
A
-----------------------------------
45
Fugue
81.32
18%
-65
- C3 -
1AQU
2
ST1E1_MOUSE
A:
[9-296]
E
Y
Y
E
V
F
G
E
F
R
G
V
L
--
M
D
K
R
F
T
K
Y
--
W
--
E
--
D
V
E
---
M
F
L
A
R
P
D
D
L
V
I
A
T
Y
P
K
S
G
T
T
W
I
S
E
V
V
Y
M
I
------------------
Y
K
E
G
-----
D
------------------
A
----
I
F
N
R
----
I
P
Y
L
E
C
R
N
----------------------
E
D
---
L
I
-----
N
G
I
K
Q
L
K
E
K
--
E
S
P
R
I
V
K
T
H
L
P
P
K
L
L
PA
S
--
F
---
W
---
E
K
N
C
K
M
I
Y
L
C
R
N
A
K
D
V
A
V
S
Y
Y
Y
F
L
L
M
I
T
S
-----------------------
Y
P
N
P
K
--
S
F
S
E
F
V
E
K
F
M
Q
G
Q
V
---------------
P
Y
G
S
W
Y
D
H
V
K
A
W
W
E
K
-
S
K
N
S
R
V
L
F
M
F
Y
E
D
M
K
E
D
I
R
R
E
V
V
K
L
I
E
F
L
E
R
K
P
S
A
E
L
V
D
R
I
I
Q
H
T
S
F
Q
E
M
K
N
---
N
P
S
T
N
Y
T
M
-
M
P
E
E
----
M
-
M
N
Q
K
V
-
S
P
F
M
R
K
G
I
I
G
D
W
K
N
H
F
P
E
A
L
R
E
R
F
D
E
H
Y
K
Q
Q
M
---
K
D
C
T
V
K
F
R
M
E
---------
28
HHSearch
80.27
20%
-73
- C3 -
1J99
5
ST2A1_HUMAN
A:
[16-292]
---------
F
E
G
I
--
A
F
P
T
M
G
F
R
S
E
T
L
R
K
--
V
R
D
---
E
F
V
I
R
D
E
D
V
I
I
L
T
Y
P
K
S
G
T
N
W
L
A
E
I
L
C
L
M
------------------
H
S
K
G
-----
D
A
--------
K
W
I
Q
S
---
V
P
----
I
W
E
R
----
S
P
W
V
E
S
E
I
-----------------------------------
G
Y
T
A
L
S
E
T
--
E
S
P
R
L
F
S
S
H
L
P
I
Q
L
F
-----
P
K
S
F
F
---
S
S
K
A
K
V
I
Y
L
M
R
N
P
R
D
V
L
V
S
G
Y
F
F
W
K
N
M
K
F
L
K
-----------------------
K
P
K
--
S
W
E
E
Y
F
E
W
F
C
Q
G
T
V
---------------
L
Y
G
S
W
F
D
H
I
H
G
W
M
P
M
-
R
E
E
K
N
F
L
L
L
S
Y
E
E
L
K
Q
D
T
G
R
T
I
E
K
I
C
Q
F
L
G
K
T
L
E
P
E
E
L
N
L
I
L
K
N
S
S
F
Q
S
M
K
----
E
N
K
M
S
N
Y
S
-
L
L
S
V
----
D
-
Y
V
V
D
K
-
T
Q
L
L
R
K
G
V
S
G
D
W
K
N
H
F
T
V
A
Q
A
E
D
F
D
K
L
F
Q
E
K
M
ADL
P
R
E
L
F
P
W
------------
7
PsiBlast_PDB
80.21
25%
-71
- C3 -
1Q1Z
2
ST2B1_HUMAN
A:
[32-276]
------------------
S
L
E
S
I
--
S
--
L
--
A
E
N
---
T
Q
D
V
R
D
D
D
I
F
I
I
T
Y
P
K
S
G
T
T
W
M
I
E
I
I
C
L
I
------------------
L
K
E
G
D----
P
S
--------
W
I
R
-
S
---
V
P
----
I
W
E
R
----
A
P
W
C
E
T
I
V
----------------------
G
A
---
F
----------
S
L
P
D
----
S
P
R
L
M
S
S
H
L
P
I
Q
I
F
-----
T
K
A
F
F
---
S
S
K
A
K
V
I
Y
M
G
R
N
P
R
D
V
V
V
S
L
Y
H
Y
S
--------------------
K
I
A
---
G
Q
L
K
D
P
G
--
T
P
D
Q
F
L
R
D
F
L
K
G
E
V
Q
--
F
G
S
W
F
D
H
I
K
G
--------------
W
L
R
M
K
G
K
D
N
F
L
F
I
T
Y
E
E
L
Q
Q
D
L
Q
G
S
V
E
R
I
C
G
F
L
G
R
P
L
G
K
E
A
L
G
S
V
V
A
H
S
T
F
S
A
M
K
A
NTM
S
N
Y
T
L
L
P
P
-
S
L
L
D
--------
H
R
R
-
G
A
F
L
R
K
G
V
C
G
D
W
K
N
H
F
T
V
A
Q
----------------------------------
34
HHSearch
79.92
23%
-72
- C3 -
2GWH
5
ST1C4_HUMAN
A:
[36-289]
-------------------------------------
N
F
Q
A
K
P
D
D
L
L
I
S
T
Y
P
K
A
G
T
T
W
T
Q
E
I
V
E
L
I
------------------
Q
N
E
G
-----
D
V
--------
E
---
K
S
K
R
A
P
----
T
H
Q
R
----
F
P
F
L
E
M
K
I
----------------------
P
S
---
L
G
-----
S
G
L
E
Q
A
H
A
M
--
P
S
P
R
I
L
K
T
H
L
P
F
H
L
L
-----
P
P
S
L
L
---
E
K
N
C
K
I
I
Y
V
A
R
N
P
K
D
N
M
V
S
Y
Y
H
F
Q
R
M
N
K
A
L
P
-----------------------
A
P
G
--
T
W
E
E
Y
F
E
T
F
L
A
G
K
V
---------------
C
W
G
S
W
H
E
H
V
K
G
W
W
E
A
-
K
D
K
H
R
I
L
Y
L
F
Y
E
D
M
K
K
N
P
K
H
E
I
Q
K
L
A
E
F
I
G
K
K
L
D
D
K
V
L
D
K
I
V
H
Y
T
S
F
D
V
M
K
----
Q
N
P
M
A
N
Y
S
-
S
I
P
A
----
E
I
M
D
H
S
I
-
S
P
F
M
R
K
G
A
V
G
D
W
K
K
H
F
T
V
A
Q
N
E
R
F
D
E
D
Y
K
K
K
M
----------------------
33
HHSearch
79.72
23%
-69
- C3 -
1Q20
3
ST2B1_HUMAN
A:
[42-288]
-------------------------------------
T
Q
D
V
R
D
D
D
I
F
I
I
T
Y
P
K
S
G
T
T
W
M
I
E
I
I
C
L
I
------------------
L
K
E
G
-----
D
P
--------
S
---
W
I
R
S
V
P
----
I
W
E
R
----
A
P
W
C
E
T
I
V
-----------------------------------
G
A
F
S
L
P
D
Q
--
Y
S
P
R
L
M
S
S
H
L
P
I
Q
I
F
-----
T
KAF
F
---
S
S
K
A
K
V
I
Y
M
G
R
N
P
R
D
V
V
V
S
L
Y
H
Y
S
K
I
A
G
Q
L
K
-----------------------
D
P
G
--
T
P
D
Q
F
L
R
D
F
L
K
G
E
V
---------------
Q
F
G
S
W
F
D
H
I
K
G
W
L
R
M
-
K
G
K
D
N
F
L
F
I
T
Y
E
E
L
Q
Q
D
L
Q
G
S
V
E
R
I
C
G
F
L
G
R
P
L
G
K
E
A
L
G
S
V
V
A
H
S
T
F
S
A
M
K
----
A
N
T
M
S
N
Y
T
-
L
L
P
P
----
S
L
L
D
H
R
R
-
G
A
F
L
R
K
G
V
C
G
D
W
K
N
H
F
T
V
A
Q
S
E
A
F
D
R
A
Y
R
K
Q
M
----------------------
8
PsiBlast_PDB
79.45
25%
-67
- C3 -
1Q20
3
ST2B1_HUMAN
A:
[32-276]
------------------
S
L
E
S
I
--
S
--
L
--
A
E
N
---
T
Q
D
V
R
D
D
D
I
F
I
I
T
Y
P
K
S
G
T
T
W
M
I
E
I
I
C
L
I
------------------
L
K
E
G
D----
P
S
--------
W
I
R
-
S
---
V
P
----
I
W
E
R
----
A
P
W
C
E
T
I
V
----------------------
G
A
---
F
----------
S
L
P
D
Q
--
Y
S
P
R
L
M
S
S
H
L
P
I
Q
I
F
-----
T
KAF
F
---
S
S
K
A
K
V
I
Y
M
G
R
N
P
R
D
V
V
V
S
L
Y
H
Y
S
--------------------
K
I
A
---
G
Q
L
K
D
P
G
--
T
P
D
Q
F
L
R
D
F
L
K
G
E
V
Q
--
F
G
S
W
F
D
H
I
K
G
--------------
W
L
R
M
K
G
K
D
N
F
L
F
I
T
Y
E
E
L
Q
Q
D
L
Q
G
S
V
E
R
I
C
G
F
L
G
R
P
L
G
K
E
A
L
G
S
V
V
A
H
S
T
F
S
A
M
K
A
NTM
S
N
Y
T
L
L
P
P
-
S
L
L
D
--------
H
R
R
-
G
A
F
L
R
K
G
V
C
G
D
W
K
N
H
F
T
V
A
Q
----------------------------------