@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1378c: (2016-05-01 )
MGNLDLLLRLSGRIVKGCRPLGSVALARCGPAVRWPRWPRPAILEHMFDLVSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNEADAGVPARRRGRGVASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALEVGRLSEWRATLIVRESACLDVEDRRALDAELCADMSALDGMGDARIAAAARAIAYRLDAQAVVERAARAETERTVTIRPAPDTMTWVTALLPVARGVSVYAALKRAADTTFDDRTRGQVMADTLVERVTGQPAEAAQPVAVNLVLSDETLLAGDRAPAVVDGYGPIPAAVARNLVRDAVADTRSRATLRRLYRHPRSGALVAMESRARRFPKGLAAFIGLRDQRCRMPYCDAPIRHRDHAQPHHRGGPTTATNGLGSCERCNYVKEAPGWRVSTDTDETGRHTAEFTTPTGMYYHCTAPPLPGPLEIDVSQVEARIGVALTHLHAA
Atome Classification :
(20 SA)
-----------------------.........---------------10....--....20-........30....--....40........50........60........70........80........90......--------..-------100.......110.......120---......-..130.......------140.......150.-.....-------------.160.......170.......180...--....--------190.......200.......210.......220.....---.-.230......-.---240.......250.......260.......270.......280.......290.......300.......310.......320.......330.-.-.....340-.-........350.-------......360.......370.-.---......-.-380--.-----------.------..-----...390--------------......-..400.--.......--.410......-----.420.......430.......440.......450.......460.......470...-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------MGNL
D
L
L
L
R
---------------LS
G
R
I
V
--KGCR
P
L
-
G
S
V
A
L
A
RCGPAVRW--PRWP
R
P
A
I
L
E
H
M
F
D
L
V
S
LAGVDSRD
D
E
A
S
L
T
A
R
I
A
E
L
E
R
V
K
S
A
A
AAG
Q
A
R
A
A
A
A
L
D
K
L
R
R
CN--------EA-------DAGVP
A
R
RRGRG
V
A
S
E
V
A
L
ARR----DSPARG-GRH
L
G
F
A
K
A
L
V
Y
------EMP
H
T
L
A
A
L
E
VG
R
L
-
S
E
W
R
A
-------------
T
L
I
V
RESACL
D
V
E
D
R
RAL
D
A
E
L
C
A
D
M
S
--
A
LDG--------MG
D
A
R
I
A
A
A
A
R
A
I
A
Y
RL
D
A
Q
A
V
V
E
R
A
ARAET
E
R
T
V
T
I
R---P-AP
D
T
M
T
W
V
T
A
-
L
---
L
P
V
AR
G
V
S
V
Y
A
A
L
K
R
AADTTFDDRTR
G
Q
V
M
A
D
T
L
V
E
R
VTGQPAEAAQ
P
V
A
V
N
L
V
LSDE
T
L
LAGDRA
P
A
VVDGYGP
I
P
A
A
V
A
R
N
L
V
R
D
A
V
AD
T
R
S
-
R
-
A
T
L
R
R
L
---
Y
-RHPRS
G
A
L
V
A
M
E
-------
S
R
A
R
RF
P
K
G
L
A
A
F
IGLR--D-Q---RCRMPY-C-DAP--I-----------R------HR-----DHAQP---------------HHRGGP-TTA--T--NGLGS
C
E
--
R
CN
Y
V
KEAPG-----
W
R
VSTDTDETGR
H
T
A
EFTTPT
G
M
Y
Y
HCTAPPLPG
P
L
E
I
D
V
S
Q
V
E
A
R
I
G
V
A
L
T
HLHAA-
27
Fugue
84.94
21%
-27
* C3 *
4L9P
11
?
B:
[68-519]
----------------------V
H
P
G
I
P
A
L
F
R
E
PPLIHDLLST
E
T
T
E
L
Q
S
E
T
V
--
N
K
C
L
P
L
L
K
G
I
H
N
S
Q
K
G
P
F
N
K
Y
GI
P
A
L
Q
R
K
D
H
L
E
Y
L
Y
D
--------------
S
L
E
D
Y
P
A
S
F
V
A
L
D
A
S
R
P
W
M
V
Y
W
A
L
A
G
L
C
L
L
-----------------------
G
E
D
V
T
R
F
R
E
R
V
I
S
T
F
T
A
A
Q
N
----
S
T
G
G
I
G
-
G
G
H
-
G
Q
M
S
H
V
A
S
------
S
Y
A
A
V
L
S
I
A
M
V
G
G
--------------------------
E
E
A
F
K
L
I
D
R
K
A
M
-
W
K
W
L
G
K
L
K
--
Q
P
D
G
GFTVCEG
G
E
E
D
V
R
G
A
Y
C
A
M
V
V
H
A
L
L
D
L
P
L
A
L
P
P
E
A
E
A
R
Q
N
G
L
E
T
F
T
---
D
G
L
P
E
Y
L
S
R
C
Q
T
-
Y
EGG
I
S
G
S
P
G
S
E
A
H
G
A
Y
A
F
C
A
L
A
C
L
C
L
L
G
R
P
E
V
V
V
P
R
Y
M
N
I
A
T
L
L
P
W
L
S
A
R
Q
Y
A
P
------
E
G
G
F
S
G
-
R
T
N
K
L
V
D
G
C
Y
S
H
W
V
G
N
C
W
P
L
V
Q
A
A
L
D
G
T
Q
P
-
L
-
A
G
P
K
R
S
S
VG
N
-
L
Y
S
R
E
G
L
T
R
Y
I
L
-------
S
C
C
Q
C
K
L
G
G
L
R
D
K
P
G
K
H
--
P
-
D
---
S
Y
H
T
C
Y
-
A
-
L
T
G
--
L
-----------
S
------
T
V
--------
Q
Y
---------------
Y
H
Y
C
T
D
-
S
S
---
V
--
S
S
K
D
D
F
S
--
S
A
F
S
W
K
H
D
P
N
-----
F
A
----
S
D
G
Q
G
S
D
I
G
V
F
T
E
N
D
R
L
V
-----
P
F
H
P
I
F
V
I
P
H
K
S
A
E
D
I
R
V
W
F
E
N
Q
S
F
D
L
--
33
Fugue
75.06
18%
-29
- C1 -
4R4X
2
?
A:
[1-546]
A
Q
T
Y
E
I
T
Y
Q
N
S
F
EGKINQN
H
I
I
S
I
T
N
S
D
K
T
L
L
---------------
F
N
E
K
I
K
N
K
K
A
D
F
P
F
-
E
V
N
E
I
N
R
K
N
N
E
V
S
Q
--
F
A
F
L
N
N
N
E
I
V
K
T
S
D
N
T
I
L
A
K
Q
E
F
--
K
P
T
S
E
T
G
K
I
L
G
Y
N
V
K
K
A
V
T
S
V
N
S
N
T
I
E
V
W
Y
T
N
D
L
K
V
K
GGPSILGQ
D
L
-------
G
L
V
L
K
T
V
R
N
G
S
S
V
V
E
A
T
S
V
K
K
I
KALD
D
Q
S
L
F
N
-
G
K
N
I
T
E
K
D
A
L
T
Y
K
D
M
I
W
K
S
R
F
I
T
I
P
V
F
E
N
E
T
I
-
N
F
S
D
A
S
K
S
D
QV
I
Q
R
F
GNG
T
I
I
L
K
K
V
K
I
P
E
I
K
Q
G
N
T
I
F
V
E
L
K
Q
K
S
N
GD
A
Y
D
R
--------
T
G
D
V
F
I
I
P
Q
E
R
A
I
S
Y
Y
T
G
L
T
Q
G
V
K
S
L
P
V
Y
Q
N
G
N
G
K
S
Y
Q
GVA
L
-
T
P
D
Y
L
P
F
I
E
L
M
R
---
F
F
T
P
F
G
I
G
H
F
N
E
K
I
Q
L
K
G
K
N
W
H
N
N
T
P
Y
R
Q
D
I
T
E
L
R
P
Q
L
S
G
K
------
E
I
L
I
G
A
F
I
G
N
Y
D
K
-
G
G
H
Q
I
S
L
E
L
S
I
H
P
D
Q
Q
K
I
V
N
N
N
F
V
L
P
V
F
N
T
T
N
V
M
E
M
A
G
Q
D
Y
P
---
T
M
F
N
S
D
K
G
V
E
V
D
F
I
L
T
K
D
L
K
N
A
Q
L
R
Y
I
T
T
G
H
G
G
W
-
G
A
G
--
D
-
E
F
V
P
K
E
N
S
I
Y
-
L
-
D
G
K
--
L
-----------
A
------
H
A
F
T
P
W
R
T
D
C
G
S
---------------
Y
R
L
F
N
P
-
A
S
G
--
N
FE
D
G
L
S
S
S
D
LS
R
S
N
W
---
C
P
G
T
I
T
N
P
V
Y
I
N
L
G
N
L
N
A
G
K
H
T
I
Q
V
K
I
P
Q
G
------
A
P
E
G
S
S
Q
S
F
W
N
V
S
G
V
--
L
L
G
Q
E
H
H
H
H
H
H
H
H
24
HHSearch
45.35
25%
-46
- C- -
1VZ0
-
SP0J_THET2
A:
[136-209]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
E
E
V
A
R
R
V
G
----
K
A
R
S
T
V
-
A
N
A
L
R
L
L
Q
-
L
---------
P
P
E
A
L
E
A
L
E
R
G
E
I
-
T
A
G
H
A
-------------
R
A
L
L
M
----
L
E
P
E
D
R
L
W
G
L
K
E
I
L
E
-------
K
G
--------
L
S
V
R
Q
A
E
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
34.99
10%
133
- C2 -
2KES
-
SNCAP_HUMAN
A:
[510-557]
---------------------------------------------------------------------------------------------------
G
S
V
E
T
C
M
S
L
A
S
Q
V
V
K
L
T
K
Q
L
K
E
Q
T
V
E
R
V
T
L
Q
N
Q
L
Q
Q
F
L
E
A
Q
--------
K
S
-------
E
G
K
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
34.78
14%
-8
- C2 -
4UMK
1
PARB_HELPY
A:
[147-226]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
E
E
L
S
K
I
V
K
----
K
S
R
A
H
V
-
A
N
I
M
R
L
L
T
-
L
---------
S
S
K
V
Q
N
A
L
L
E
E
K
I
-
T
S
G
H
A
-------------
K
V
L
V
G
L
----
D
G
E
K
Q
E
L
I
L
N
S
I
I
G
-------
Q
K
--------
L
S
V
R
Q
T
E
D
L
A
R
D
F
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
34.31
27%
57
- C2 -
4H9D
2
?
A:
[28-83]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
W
K
N
R
I
--
A
R
G
---
I
C
H
Y
---
C
-
G
E
I
--
F
P
PEE-------
L
------
T
M
-----
D
H
L
V
P
---------------
V
V
R
G
G
K
-
S
T
R
--
G
--
N
V
V
P
A
C
K
--
E
C
N
N
R
K
K
Y
L
----------------------------------------------------------------
28
Fugue
33.89
12%
73
- C2 -
1T3J
-
MFN1_MOUSE
A:
[674-735]
-----------------------------------------------------------------------------------
A
T
T
F
A
R
L
C
Q
Q
V
D
M
T
Q
K
H
L
E
E
E
I
A
R
L
S
K
E
I
D
Q
L
E
K
M
Q
N
N
S
K
L
L
R
N
K
A
V
Q
L
E
S
E
L
E
N
F
S
--------
K
Q
-------
F
L
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
33.37
26%
24
- C2 -
4OGE
3
CAS9_ACTNH
A:
[553-619]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
R
L
D
A
L
E
L
--
Q
G
C
---
A
C
L
Y
---
C
-
G
T
T
--
I
GYHT-------
C
------
Q
L
-----
D
H
I
V
P
---------------
Q
A
G
P
G
S
N
N
R
R
--
G
--
N
L
V
A
V
C
E
--
R
C
N
R
S
K
S
N
T
P
-----
F
A
V
-------------------------------------------------------
11
HHSearch
33.02
14%
45
- C2 -
3M7K
10
?
A:
[47-119]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
A
T
F
L
A
W
Y
G
L
SA
Q
-
R
---
H
C
G
Y
---
C
-
G
I
S
--
E
-----------
A
------
G
F
-----
T
S
L
H
R
TNPRGYHIQ
C
L
G
V
D
R
S
D
S
F
E
G
-
Y
S
P
--
Q
--
N
A
R
L
A
C
F
--
I
C
N
R
I
K
S
N
I
----------------------------------------------------------------
1
PsiBlast_PDB
27.18
35%
143
- C2 -
3AGR
-
?
A:
[12-71]
----------------------------------------------------------------------------------------------------------------
A
E
T
E
K
---
H
I
S
A
G
K
A
R
L
Q
D
L
R
D
A
E
R
R
C
H
--------
D
A
W
Q
A
I
V
V
I
D
G
G
S
S
A
T
R
------
T
N
V
F
L
A
K
T
----
R
S
C
P
R
G
-
G
R
H
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
26.85
13%
186
- C2 -
3HRO
-
PKD2_HUMAN
A:
[834-870]
---------------------------------------------------------------------------------------------------
V
S
Y
E
E
F
Q
V
L
V
R
R
V
D
R
M
E
H
S
I
G
S
I
V
S
K
I
D
A
V
I
V
K
L
E
I
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
26.65
20%
44
- C2 -
1R71
2
KORB2_ECOLX
A:
[54-104]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
G
D
I
A
K
E
I
G
----
K
S
P
A
F
I
-
T
Q
H
V
T
L
L
D
-
L
---------
P
E
K
I
A
D
A
F
N
T
G
R
V
R
D
V
T
V
V
-------------
N
E
L
V
T
A
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
26.59
13%
32
- C2 -
5CZZ
-
?
A:
[524-596]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
K
I
K
L
H
D
M
--
Q
E
G
---
K
C
L
Y
---
S
-
L
E
A
--
I
P
L
E
D
L
L
N
NPFN
Y
------
E
V
-----
D
H
I
I
P
---------------
R
S
V
S
F
D
-
N
S
F
--
N
--
N
K
V
L
V
K
Q
--
E
E
A
S
K
K
G
N
R
----------------------------------------------------------------
10
HHSearch
26.10
18%
53
- C2 -
1E7L
4
END7_BPT4
A:
[6-67]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
Y
K
E
E
K
Q
K
F
Y
D
A
--
Q
N
G
---
K
C
L
I
---
C
-
Q
R
E
--
L
-----------
N
PDVQAN
H
L
-----
D
H
D
H
E
---------------
L
N
-
G
-
P
-
K
A
G
--
K
--
V
R
G
L
L
C
N
--
L
C
D
A
A
E
G
Q
-----------------------------------------------------------------
26
Fugue
25.23
13%
185
* C2 *
2BEQ
-
SPIKE_CVHSA
A:
[914-949]
-----------------------------------------------------------------------------------------------------
S
Q
I
Q
E
S
L
T
T
T
S
T
A
L
G
K
L
Q
D
V
V
N
Q
N
A
Q
A
L
N
T
L
V
K
Q
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
25.22
15%
45
- C3 -
2JU2
-
A:
[1-95]
-------------------------------------------------------------------------------------------------------
G
S
H
M
L
R
D
R
L
A
G
L
P
R
A
E
R
T
A
E
L
V
R
L
V
R
T
S
T
A
T
V
L
G
H
D
D
--------
P
K
-------
A
V
R
A
T
T
P
F
K
E
L
G
F
D
S
L
A
A
V
R
L
R
----
N
L
L
N
A
A
T
G
L
R
L
P
S
T
L
V
F
D
H
------
P
N
A
S
A
V
A
G
F
L
D
A
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
24.23
27%
104
- C2 -
4KZX
-
?
V:
[28-81]
-------------------------------------------------------------------------------------------------------
D
H
A
S
I
P
M
N
V
A
E
V
D
K
V
-
T
G
R
F
N
G
Q
S
K
T
Y
A
I
C
G
A
I
R
R
M
G
--------
E
S
-------
D
D
S
I
L
R
L
A
K
S
H
G
I
V
S
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
24.20
27%
104
- C2 -
4KZY
-
?
V:
[28-81]
-------------------------------------------------------------------------------------------------------
D
H
A
S
I
P
M
N
V
A
E
V
D
K
V
-
T
G
R
F
N
G
Q
S
K
T
Y
A
I
C
G
A
I
R
R
M
G
--------
E
S
-------
D
D
S
I
L
R
L
A
K
S
H
G
I
V
S
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
24.13
27%
104
- C2 -
4KZZ
-
?
V:
[28-81]
-------------------------------------------------------------------------------------------------------
D
H
A
S
I
P
M
N
V
A
E
V
D
K
V
-
T
G
R
F
N
G
Q
S
K
T
Y
A
I
C
G
A
I
R
R
M
G
--------
E
S
-------
D
D
S
I
L
R
L
A
K
S
H
G
I
V
S
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
23.65
18%
92
- C2 -
3G27
3
YBCO_ECOLI
A:
[5-65]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
A
A
R
G
R
--
E
-
C
---
Q
V
R
I
P
G
V
C
N
G
N
P
ET
S
-----------
V
------
L
A
-----
H
I
R
-------------------------
K
P
PD
L
--
I
A
T
I
A
C
S
--
A
C
H
D
E
I
D
R
R
T
---------------------------------------------------------------