@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1436: (2016-05-01 )
MTVRVGINGFGRIGRNFYRALLAQQEQGTADVEVVAANDITDNSTLAHLLKFDSILGRLPCDVGLEGDDTIVVGRAKIKALAVREGPAALPWGDLGVDVVVESTGLFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQNIISNASCTTNCLAPLAKVLDDEFGIVKGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVMPQLKGKLDGYALRVPIPTGSVTDLTVDLSTRASVDEINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIFDSGLTKVIDDQAKVVSWYDNEWGYSNRLVDLVTLVGKSL
Atome Classification :
(44 SA)
.........10........20..--.-.....30........-40.........50........60.-.......70........80........90........100.......110.......120.......130.......140.....-.-.150-........160.......170.......180.......190......---.200..-.....210.......220.......230.......240.......250...-..-..260.......270-------.-------......280......-.290.......300......-.-310........320.......330.......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
V
R
V
GI
N
G
F
G
R
I
G
R
N
F
Y
R
A
L
L
A
--Q-QEQGTA
D
V
E
V
V
A
AND-I-TD
N
S
T
L
A
H
L
L
K
F
D
S
I
L
GRLPCD-VGLEGD
D
T
I
V
V
GR
A
K
I
K
A
L
A
VREGPAALPWGDL
G
V
D
V
V
V
ESTGLFTNAAKAKGHLDAGA
K
K
V
I
I
SAPATDE
D
I
T
I
V
L
GVNDDKYD-G-SQ-N-IISNASC
T
T
N
C
L
A
P
L
A
K
VLDD
E
F
G
I
V
K
G
L
M
T
T
I
H
A
YTQDQNLQDG
P
H
---
K
D
L
R
R
A
-
R
A
A
A
L
N
I
V
PTSTGA
A
K
A
I
G
L
V
M
P
Q
LKGKLD
G
Y
A
L
R
VPIPTGS
V
T
D
L
T
V
DLS-TR-A
S
V
D
E
I
N
A
A
F
K
A
A
AE-------
G
-------
R
L
K
G
I
L
K
Y
YDAPIVS-SDIVTDP
H
S
S
I
F
D
S
G
L
T
K
V
I-D-DQ-
A
K
V
V
S
W
YDNEWGYS
N
R
L
V
D
L
V
T
L
VGKSL-
106
Fugue
94.30
60%
-88
- C2 -
1CER
2
G3P_THEAQ
O:
[1-331]
--
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
S
--
R
-
G
V
------
E
V
A
L
I
N
D
L--
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
I
Y
H
R
F
P
G
E
-
V
A
Y
D
-
D
Q
Y
L
Y
V
D
G
K
A
I
R
A
T
A
V
-
K
D
P
K
E
I
P
W
A
E
A
G
V
G
V
V
I
E
S
T
G
V
F
T
D
A
D
K
A
K
A
H
L
E
G
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
I
V
M
G
V
N
H
E
A
Y
D
-
P
-
S
R
H
H
-
I
I
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
E
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
L
R
R
A
R
A
A
-
A
I
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
A
T
G
S
I
S
D
I
T
A
L
L
K
-
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
Q-
D
I
V
M
D
P
H
S
S
I
V
D
A
K
L
T
K
A
L
-
G
-
N
M
-
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
L
R
K
G
V
59
PsiBlast_CBE
93.36
60%
-92
- C2 -
1CER
2
G3P_THEAQ
D:
[1-326]
--
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
S
--
R
-------
G
V
E
V
A
L
I
N
D
-
L
-
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
I
Y
H
R
F
P
G
E
-
V
A
Y
D
D
Q
Y
L
Y
V
D
G
K
A
-
I
R
A
T
A
V
K
D
-
P
K
E
I
P
W
A
E
A
G
V
G
V
V
I
E
S
T
G
V
F
T
D
A
D
K
A
K
A
H
L
E
G
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
I
V
M
G
V
N
H
E
A
Y
D
-
P
-
S
R
-
H
H
I
I
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
E
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
L
R
R
A
-
R
A
A
A
I
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
A
T
G
S
I
S
D
I
T
A
L
L
K
-
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
-
Q
D
I
V
M
D
P
H
S
S
I
V
D
A
K
L
T
K
A
L
-
G
-
N
M
-
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
-----
56
PsiBlast_CBE
93.32
60%
-92
- C2 -
1CER
2
G3P_THEAQ
R:
[1-326]
--
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
S
--
R
-------
G
V
E
V
A
L
I
N
D
-
L
-
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
I
Y
H
R
F
P
G
E
-
V
A
Y
D
D
Q
Y
L
Y
V
D
G
K
A
-
I
R
A
T
A
V
K
D
-
P
K
E
I
P
W
A
E
A
G
V
G
V
V
I
E
S
T
G
V
F
T
D
A
D
K
A
K
A
H
L
E
G
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
I
V
M
G
V
N
H
E
A
Y
D
-
P
-
S
R
-
H
H
I
I
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
E
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
L
R
R
A
-
R
A
A
A
I
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
A
T
G
S
I
S
D
I
T
A
L
L
K
-
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
-
Q
D
I
V
M
D
P
H
S
S
I
V
D
A
K
L
T
K
A
L
-
G
-
N
M
-
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
-----
118
HHSearch
93.27
55%
-90
- C2 -
1RM4
3
G3PA_SPIOL
O:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
-
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
--
133
HHSearch
92.92
61%
-87
* C2 *
3CMC
14
G3P_GEOSE
O:
[1-332]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
--
N
------
P
D
I
E
V
V
A
V
N
D
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
-
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
-
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
-
P
K
A
H
-
H
-
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
---
K
D
L
R
R
A
-
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
-
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
-
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
-
D
G
K
M
-
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
--
61
PsiBlast_CBE
92.91
60%
-90
- C2 -
1CER
2
G3P_THEAQ
B:
[1-326]
--
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
S
--
R
-------
G
V
E
V
A
L
I
N
D
-
L
-
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
I
Y
H
R
F
P
G
E
-
V
A
Y
D
D
Q
Y
L
Y
V
D
G
K
A
-
I
R
A
T
A
V
K
D
-
P
K
E
I
P
W
A
E
A
G
V
G
V
V
I
E
S
T
G
V
F
T
D
A
D
K
A
K
A
H
L
E
G
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
I
V
M
G
V
N
H
E
A
Y
D
-
P
-
S
R
-
H
H
I
I
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
E
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
L
R
R
A
-
R
A
A
A
I
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
A
T
G
S
I
S
D
I
T
A
L
L
K
-
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
-
Q
D
I
V
M
D
P
H
S
S
I
V
D
A
K
L
T
K
A
L
-
G
-
N
M
-
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
-----
64
PsiBlast_CBE
92.90
56%
-87
- C2 -
3DOC
2
?
C:
[1-333]
M
A
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
V
------
E
S
G
R
T
D
I
Q
V
V
A
I
N
D
-
L
-
G
P
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
R
F
P
K
E
-
V
E
V
A
G
D
-
T
I
D
V
G
Y
G
P
I
K
V
H
A
V
R
N
-
P
A
E
L
P
W
K
E
E
N
V
D
I
A
L
E
C
T
G
I
F
T
S
R
D
K
A
A
L
H
L
E
A
G
A
K
R
V
I
V
S
A
P
A
D
G
A
D
L
T
V
V
Y
G
V
N
N
D
K
L
T
-
K
-
D
H
-
L
-
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
N
D
T
I
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
T
L
D
T
M
H
---
K
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
D
G
V
A
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
I
A
K
-
R
E
-
T
T
V
E
E
V
N
N
A
I
R
E
A
A
N
-------
G
-------
R
L
K
G
I
L
G
Y
T
D
E
K
L
V
S
-
H
D
F
N
H
D
S
H
S
S
V
F
H
T
D
Q
T
K
V
M
-
D
G
T
M
-
V
R
I
L
S
W
Y
D
N
E
W
G
F
S
S
R
M
S
D
T
A
V
A
L
G
K
---
117
HHSearch
92.58
53%
-91
- C2 -
2B4R
4
?
O:
[11-344]
-
A
T
K
L
G
I
N
G
F
G
R
I
G
R
L
V
F
R
A
A
F
G
--
R
------
K
D
I
E
V
V
A
I
N
D
-
P
F
M
D
L
N
H
L
C
Y
L
L
K
Y
D
S
V
H
G
Q
F
P
C
E
-
V
T
H
A
-
D
G
F
L
L
I
G
E
K
K
V
S
V
F
A
E
K
-
D
P
S
Q
I
P
W
G
K
C
Q
V
D
V
V
C
E
S
T
G
V
F
L
T
K
E
L
A
S
S
H
L
K
G
G
A
K
K
V
I
M
S
A
P
P
K
D
D
T
P
I
Y
V
M
G
I
N
H
H
Q
Y
D
-
T
-
K
Q
-
L
-
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
R
F
G
I
V
E
G
L
M
T
T
V
H
A
S
T
A
N
Q
L
V
V
D
G
P
S
KGG
K
D
W
R
A
G
-
R
C
A
L
S
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
V
A
F
R
V
P
I
G
T
V
S
V
V
D
L
V
C
R
L
Q
-
K
P
-
A
K
Y
E
E
V
A
L
E
I
K
K
A
A
E
-------
G
-------
P
L
K
G
I
L
G
Y
T
E
D
E
V
V
S
-
Q
D
F
V
H
D
N
R
S
S
I
F
D
M
K
A
G
L
A
L
-
N
D
N
F
-
F
K
L
V
S
W
Y
D
N
E
W
G
Y
S
N
R
V
L
D
L
A
V
H
I
T
T
---
58
PsiBlast_CBE
92.57
60%
-90
- C2 -
1CER
2
G3P_THEAQ
P:
[1-326]
--
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
S
--
R
-------
G
V
E
V
A
L
I
N
D
-
L
-
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
I
Y
H
R
F
P
G
E
-
V
A
Y
D
D
Q
Y
L
Y
V
D
G
K
A
-
I
R
A
T
A
V
K
D
-
P
K
E
I
P
W
A
E
A
G
V
G
V
V
I
E
S
T
G
V
F
T
D
A
D
K
A
K
A
H
L
E
G
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
I
V
M
G
V
N
H
E
A
Y
D
-
P
-
S
R
-
H
H
I
I
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
E
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
L
R
R
A
-
R
A
A
A
I
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
A
T
G
S
I
S
D
I
T
A
L
L
K
-
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
-
Q
D
I
V
M
D
P
H
S
S
I
V
D
A
K
L
T
K
A
L
-
G
-
N
M
-
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
-----
16
PsiBlast_PDB
92.56
56%
-90
- C2 -
3DOC
2
?
A:
[1-333]
M
A
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
V
------
E
S
G
R
T
D
I
Q
V
V
A
I
N
D
-
L
-
G
P
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
R
F
P
K
E
-
V
E
V
A
G
D
-
T
I
D
V
G
Y
G
P
I
K
V
H
A
V
R
N
-
P
A
E
L
P
W
K
E
E
N
V
D
I
A
L
E
C
T
G
I
F
T
S
R
D
K
A
A
L
H
L
E
A
G
A
K
R
V
I
V
S
A
P
A
D
G
A
D
L
T
V
V
Y
G
V
N
N
D
K
L
T
-
K
-
D
H
-
L
-
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
N
D
T
I
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
T
L
D
T
M
H
---
K
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
D
G
V
A
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
I
A
K
-
R
E
-
T
T
V
E
E
V
N
N
A
I
R
E
A
A
N
-------
G
-------
R
L
K
G
I
L
G
Y
T
D
E
K
L
V
S
-
H
D
F
N
H
D
S
H
S
S
V
F
H
T
D
Q
T
K
V
M
-
D
G
T
M
-
V
R
I
L
S
W
Y
D
N
E
W
G
F
S
S
R
M
S
D
T
A
V
A
L
G
K
---
15
PsiBlast_PDB
92.55
60%
-91
- C2 -
1CER
2
G3P_THEAQ
O:
[1-326]
--
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
S
--
R
-------
G
V
E
V
A
L
I
N
D
-
L
-
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
I
Y
H
R
F
P
G
E
-
V
A
Y
D
D
Q
Y
L
Y
V
D
G
K
A
-
I
R
A
T
A
V
K
D
-
P
K
E
I
P
W
A
E
A
G
V
G
V
V
I
E
S
T
G
V
F
T
D
A
D
K
A
K
A
H
L
E
G
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
I
V
M
G
V
N
H
E
A
Y
D
-
P
-
S
R
-
H
H
I
I
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
E
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
L
R
R
A
-
R
A
A
A
I
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
A
T
G
S
I
S
D
I
T
A
L
L
K
-
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
-
Q
D
I
V
M
D
P
H
S
S
I
V
D
A
K
L
T
K
A
L
-
G
-
N
M
-
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
-----
129
HHSearch
92.50
60%
-86
- C2 -
2EP7
1
G3P_AQUAE
A:
[3-340]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
--
R
------
E
E
I
E
I
V
A
I
N
D
-
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
-
V
E
A
K
-
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
-
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
-
P
K
E
H
-
N
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
F
R
R
A
-
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
-
K
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGK
V
-------
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
-
D
-
N
L
-
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
--
60
PsiBlast_CBE
92.43
60%
-91
- C2 -
1CER
2
G3P_THEAQ
C:
[1-326]
--
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
S
--
R
-------
G
V
E
V
A
L
I
N
D
-
L
-
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
I
Y
H
R
F
P
G
E
-
V
A
Y
D
D
Q
Y
L
Y
V
D
G
K
A
-
I
R
A
T
A
V
K
D
-
P
K
E
I
P
W
A
E
A
G
V
G
V
V
I
E
S
T
G
V
F
T
D
A
D
K
A
K
A
H
L
E
G
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
I
V
M
G
V
N
H
E
A
Y
D
-
P
-
S
R
-
H
H
I
I
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
E
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
L
R
R
A
-
R
A
A
A
I
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
A
T
G
S
I
S
D
I
T
A
L
L
K
-
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
-
Q
D
I
V
M
D
P
H
S
S
I
V
D
A
K
L
T
K
A
L
-
G
-
N
M
-
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
-----
66
PsiBlast_CBE
92.34
53%
-89
- C2 -
3L0D
1
?
B:
[22-356]
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
------
E
S
G
R
Q
D
I
E
V
V
A
L
N
D
-
L
-
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
P
G
T
-
V
Q
V
V
G
D
-
A
I
D
I
---
L
I
K
V
F
A
E
R
D
-
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
S
E
G
A
D
L
T
V
V
Y
G
V
N
H
Q
F
L
S
-
K
-
E
H
-
H
-
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
---
R
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
-
R
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
-------
G
-------
S
L
K
G
I
L
D
Y
T
D
E
K
L
V
S
-
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
-
D
-
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
K
T
I
-
45
PsiBlast_CBE
92.32
58%
-87
- C2 -
1DBV
3
G3P_GEOSE
R:
[2-330]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
--
N
-
P
-----
D
I
E
V
V
A
V
N
G
-
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
N
N
L
V
V
N
G
K
E
I
I
--
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
-
A
H
-
H
-
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
---
K
D
L
R
R
A
-
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
-
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
-
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
-
D
-
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
----
63
PsiBlast_CBE
92.28
56%
-87
- C2 -
3DOC
2
?
D:
[2-333]
-
A
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
V
------
E
S
G
R
T
D
I
Q
V
V
A
I
N
D
-
L
-
G
P
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
R
F
P
K
E
-
V
E
V
A
G
D
-
T
I
D
V
G
Y
G
P
I
K
V
H
A
V
R
N
-
P
A
E
L
P
W
K
E
E
N
V
D
I
A
L
E
C
T
G
I
F
T
S
R
D
K
A
A
L
H
L
E
A
G
A
K
R
V
I
V
S
A
P
A
D
G
A
D
L
T
V
V
Y
G
V
N
N
D
K
L
T
-
K
-
D
H
-
L
-
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
N
D
T
I
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
T
L
D
T
M
H
---
K
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
D
G
V
A
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
I
A
K
-
R
E
-
T
T
V
E
E
V
N
N
A
I
R
E
A
A
N
-------
G
-------
R
L
K
G
I
L
G
Y
T
D
E
K
L
V
S
-
H
D
F
N
H
D
S
H
S
S
V
F
H
T
D
Q
T
K
V
M
-
D
G
T
M
-
V
R
I
L
S
W
Y
D
N
E
W
G
F
S
S
R
M
S
D
T
A
V
A
L
G
K
---
121
HHSearch
92.20
57%
-89
- C2 -
3DOC
2
?
A:
[1-335]
M
A
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
V
E
--
S
-
G
R
---
T
D
I
Q
V
V
A
I
N
D
-
L
-
G
P
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
R
F
P
K
E
-
V
E
V
A
-
G
D
T
I
D
V
G
Y
G
P
I
K
V
H
A
V
R
-
N
P
A
E
L
P
W
K
E
E
N
V
D
I
A
L
E
C
T
G
I
F
T
S
R
D
K
A
A
L
H
L
E
A
G
A
K
R
V
I
V
S
A
P
A
D
G
A
D
L
T
V
V
Y
G
V
N
N
D
K
L
T
-
K
-
D
H
-
L
-
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
N
D
T
I
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
T
L
D
T
M
H
---
K
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
D
G
V
A
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
I
A
K
-
R
E
-
T
T
V
E
E
V
N
N
A
I
R
E
A
A
N
-------
G
-------
R
L
K
G
I
L
G
Y
T
D
E
K
L
V
S
-
H
D
F
N
H
D
S
H
S
S
V
F
H
T
D
Q
T
K
V
M
-
D
G
T
M
-
V
R
I
L
S
W
Y
D
N
E
W
G
F
S
S
R
M
S
D
T
A
V
A
L
G
K
L
I
-
123
HHSearch
92.14
58%
-87
- C2 -
1HDG
3
G3P_THEMA
O:
[1-332]
--
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
RK
N
------
P
D
I
E
V
V
A
I
N
D
-
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
-
V
E
Y
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
-
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
-
P
-
E
H
-
T
-
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
---
K
D
L
R
R
A
-
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
-
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
-------
G
-------
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
-
G
G
K
L
-
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
57
PsiBlast_CBE
92.09
60%
-91
- C2 -
1CER
2
G3P_THEAQ
Q:
[1-326]
--
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
S
--
R
-------
G
V
E
V
A
L
I
N
D
-
L
-
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
I
Y
H
R
F
P
G
E
-
V
A
Y
D
D
Q
Y
L
Y
V
D
G
K
A
-
I
R
A
T
A
V
K
D
-
P
K
E
I
P
W
A
E
A
G
V
G
V
V
I
E
S
T
G
V
F
T
D
A
D
K
A
K
A
H
L
E
G
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
I
V
M
G
V
N
H
E
A
Y
D
-
P
-
S
R
-
H
H
I
I
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
E
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
L
R
R
A
-
R
A
A
A
I
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
A
T
G
S
I
S
D
I
T
A
L
L
K
-
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
-
Q
D
I
V
M
D
P
H
S
S
I
V
D
A
K
L
T
K
A
L
-
G
-
N
M
-
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
-----
104
PsiBlast_CBE
92.08
54%
-93
- C2 -
2PKR
2
G3PA_SPIOL
C:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
86
PsiBlast_CBE
92.05
54%
-92
- C2 -
1RM4
3
G3PA_SPIOL
O:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
11
PsiBlast_PDB
91.93
60%
-85
- C2 -
1VC2
1
?
A:
[1-329]
--
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
------
H
E
R
G
---
V
E
V
A
L
I
N
D
-
L
-
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
T
Y
G
R
F
P
G
A
-
V
G
Y
D
E
E
N
L
Y
V
D
G
K
A
-
I
R
A
T
A
I
K
D
-
P
R
E
I
P
W
K
Q
A
G
V
G
V
V
V
E
S
T
G
V
F
T
D
G
E
K
A
R
A
H
L
E
A
G
A
K
K
V
I
I
T
A
P
A
K
N
E
D
I
T
V
V
L
G
V
N
H
E
Q
Y
D
P
A
-
K
H
-
H
-
I
L
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
K
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
L
R
R
A
-
R
A
A
A
L
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
P
T
G
S
I
S
D
I
T
A
L
L
K
-
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
-------
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
-
R
D
I
V
M
D
P
H
S
S
I
V
D
G
K
L
T
K
A
I
-
G
-
N
L
-
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
L
K
K
--
17
PsiBlast_PDB
91.87
53%
-88
- C2 -
3L0D
1
?
A:
[22-356]
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
------
E
S
G
R
Q
D
I
E
V
V
A
L
N
D
-
L
-
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
P
G
T
-
V
Q
V
V
G
D
-
A
I
D
I
---
L
I
K
V
F
A
E
R
D
-
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
S
E
G
A
D
L
T
V
V
Y
G
V
N
H
Q
F
L
S
-
K
-
E
H
-
H
-
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
---
R
D
L
Y
R
A
-
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
-
R
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
-------
G
-------
S
L
K
G
I
L
D
Y
T
D
E
K
L
V
S
-
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
-
D
-
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
K
T
I
-
79
PsiBlast_CBE
91.57
54%
-93
- C2 -
1RM5
4
G3PA_SPIOL
O:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
A
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
14
PsiBlast_PDB
91.54
58%
-82
- C2 -
1HDG
3
G3P_THEMA
O:
[2-331]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
------
E
R
K
N
P
D
I
E
V
V
A
I
N
D
-
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
-
V
E
Y
T
E
N
S
L
I
V
D
G
K
-
E
I
K
V
F
A
-
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
-
P
-
E
H
-
T
-
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
---
K
D
L
R
R
A
-
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
-
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
-------
G
-------
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
-
G
-
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
---
131
HHSearch
91.52
52%
-86
- C2 -
4BOY
1
?
A:
[17-352]
S
M
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
--
R
K
A
N
---
S
K
L
E
I
V
G
I
N
D
-
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
D
-
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
-
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
-
P
-
S
E
-
D
-
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
-
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
-------
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
-
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
-
G
G
N
L
-
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
--
126
HHSearch
91.49
53%
-95
- C2 -
3PYM
3
G3P3_YEAST
A:
[1-331]
-
M
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
I
A
L
S
--
R
------
P
N
V
E
V
V
A
L
N
D
-
P
F
I
T
N
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
R
Y
A
G
E
-
V
S
H
D
-
D
K
H
I
I
V
D
G
K
K
I
A
T
Y
Q
E
R
-
D
P
A
N
L
P
W
G
S
S
N
V
D
I
A
I
D
S
T
G
V
F
K
E
L
D
T
A
Q
K
H
I
D
A
G
A
K
K
V
V
I
T
A
P
S
S
T
-
A
P
M
F
V
M
G
V
N
E
E
K
Y
T
-
S
-
D
L
-
K
-
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
P
S
H--
K
D
W
R
G
G
-
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
K
L
N
-
K
E
-
T
T
Y
D
E
I
K
K
V
V
K
A
A
A
E
-------
G
-------
K
L
K
G
V
L
G
Y
T
E
D
A
V
V
S
-
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
G
I
Q
L
-
S
P
K
F
-
V
K
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
---
48
PsiBlast_CBE
91.39
57%
-87
- C2 -
2EP7
1
G3P_AQUAE
B:
[2-339]
-
A
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
--
R
-
E
E
-----
I
E
I
V
A
I
N
D
-
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
-
V
E
A
K
-
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
-
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
-
P
-
K
E
H
N
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
F
R
R
A
-
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
-
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
-------
K
Y
R
E
SGKV
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
-
D
-
N
L
-
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
---
80
PsiBlast_CBE
91.26
54%
-93
- C2 -
1RM5
5
G3PA_SPIOL
B:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
A
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
90
PsiBlast_CBE
91.02
54%
-94
- C2 -
1NBO
4
G3PA_SPIOL
B:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
81
PsiBlast_CBE
90.95
54%
-94
- C2 -
1RM5
5
G3PA_SPIOL
A:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
A
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
94
PsiBlast_CBE
90.93
54%
-93
- C2 -
1RM3
6
G3PA_SPIOL
A:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
A
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
55
PsiBlast_CBE
90.93
58%
-82
- C2 -
1HDG
3
G3P_THEMA
Q:
[2-331]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
------
E
R
K
N
P
D
I
E
V
V
A
I
N
D
-
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
-
V
E
Y
T
E
N
S
L
I
V
D
G
K
-
E
I
K
V
F
A
-
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
-
P
-
E
H
-
T
-
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
---
K
D
L
R
R
A
-
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
-
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
-------
G
-------
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
-
G
-
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
---
10
PsiBlast_PDB
90.91
57%
-85
- C2 -
2EP7
1
G3P_AQUAE
A:
[3-339]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
--
R
-
E
E
-----
I
E
I
V
A
I
N
D
-
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
-
V
E
A
K
-
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
-
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
-
P
-
K
E
H
N
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
F
R
R
A
-
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
-
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
-------
K
Y
R
E
SGKV
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
-
D
-
N
L
-
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
---
88
PsiBlast_CBE
90.89
54%
-92
- C2 -
1RM4
6
G3PA_SPIOL
A:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
92
PsiBlast_CBE
90.00
54%
-90
- C2 -
1RM3
5
G3PA_SPIOL
O:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
A
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
87
PsiBlast_CBE
89.84
54%
-92
- C2 -
1RM4
5
G3PA_SPIOL
B:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
93
PsiBlast_CBE
89.74
54%
-90
- C2 -
1RM3
5
G3PA_SPIOL
B:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
A
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
125
HHSearch
89.64
50%
-92
- C2 -
3CPS
1
?
A:
[18-352]
--
G
T
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
--
R
------
N
D
I
T
V
V
A
I
N
D
-
P
F
M
D
V
E
Y
M
A
Y
L
L
K
Y
D
S
V
H
G
N
F
N
G
T
-
V
E
V
S
-
G
-
D
L
C
I
N
G
K
V
V
K
V
F
Q
A
K
-
D
P
A
E
I
P
W
G
A
S
G
A
Q
I
V
C
E
S
T
G
V
F
T
T
E
E
K
A
S
L
H
L
K
G
G
A
K
K
V
I
I
S
A
P
P
K
D
N
V
P
M
Y
V
M
G
V
N
N
T
E
Y
D
-
P
S
K
F
-
N
-
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
P
S
KG--
D
W
R
A
G
-
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
-
K
P
-
A
S
I
E
E
I
Y
Q
A
V
K
E
A
S
N
-------
G
-------
P
M
K
G
I
M
G
Y
T
S
D
D
V
V
S
-
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
I
A
L
-
N
D
S
F
-
V
K
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
D
L
A
V
Y
V
A
S
R
--
89
PsiBlast_CBE
89.42
54%
-89
- C2 -
1NBO
3
G3PA_SPIOL
O:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
91
PsiBlast_CBE
89.36
54%
-91
- C2 -
1NBO
4
G3PA_SPIOL
A:
[2-331]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
-
K
D
---
S
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
127
HHSearch
89.20
49%
-92
- C2 -
4LSM
5
?
A:
[16-346]
-
T
I
K
I
G
I
N
G
F
G
R
I
G
R
M
V
F
R
A
A
Q
H
--
R
------
N
D
I
E
I
V
G
I
N
D
-
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
Y
G
G
M
-
V
E
V
R
-
E
G
A
L
V
V
N
G
K
K
I
R
V
T
S
E
R
-
D
P
A
N
L
K
W
N
E
V
G
A
V
V
V
V
E
S
T
G
L
F
L
T
D
E
T
A
R
K
H
I
Q
A
G
A
K
K
V
V
M
T
G
P
P
K
D
D
T
P
M
F
V
M
G
V
N
N
T
M
Y
K
---
G
Q
-
E
-
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
H
E
K
F
G
I
V
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
Q--
K
D
W
R
G
G
-
R
G
A
A
Q
N
I
I
P
S
A
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
R
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
A
R
L
E
-
R
P
-
A
T
Y
E
Q
I
C
A
A
I
K
A
A
S
E
-------
G
-------
E
L
K
G
I
L
G
Y
T
E
D
E
V
V
S
-
T
D
M
N
G
V
A
L
T
S
V
F
D
V
K
A
G
I
S
L
-
N
D
R
F
-
V
K
L
I
S
W
Y
D
N
E
T
G
Y
S
H
K
V
L
D
L
V
A
Y
I
S
A
H
--
20
PsiBlast_PDB
88.78
55%
-88
- C2 -
1JN0
3
G3PA_SPIOL
O:
[2-329]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
K
-
D
----
S
P
L
D
V
V
V
I
N
D
-
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
G
K
V
-
I
K
V
V
S
D
R
N
-
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
-
H
-
A
D
-
T
-
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
-
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
Q
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
-
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
Q
-------
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
-
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
-
D
M
-
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
-----
134
HHSearch
87.98
48%
-90
- C2 -
3H9E
10
G3PT_HUMAN
O:
[6-337]
R
E
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
--
K
-------
G
V
K
V
V
A
V
N
D
-
P
F
I
D
P
E
Y
M
V
Y
M
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H
G
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-
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N
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Q
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N
H
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N
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-
N
-
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S
N
A
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R--
K
A
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-
R
G
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N
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-
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P
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A
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A
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K
E
A
V
K
A
A
A
K
-------
G
-------
P
M
A
G
I
L
A
Y
T
E
D
E
V
V
S
-
T
D
F
L
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A
K
A
G
I
A
L
-
N
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W
Y
D
N
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Y
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H
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V
V
D
L
L
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Y
M
F
S
---