@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1437: (2016-05-01 )
MSVANLKDLLAEGVSGRGVLVRSDLNVPLDEDGTITDAGRIIASAPTLKALLDADAKVVVAAHLGRPKDGPDPTLSLAPVAVALGEQLGRHVQLAGDVVGADALARAEGLTGGDILLLENIRFDKRETSKNDDDRRALAKQLVELVGTGGVFVSDGFGVVHRKQASVYDIATLLPHYAGTLVADEMRVLEQLTSSTQRPYAVVLGGSKVSDKLGVIESLATKADSIVIGGGMCFTFLAAQGFSVGTSLLEDDMIEVCRGLLETYHDVLRLPVDLVVTEKFAADSPPQTVDVGAVPNGLMGLDIGPGSIKRFSTLLSNAGTIFWNGPMGVFEFPAYAAGTRGVAEAIVAATGKGAFSVVGGGDSAAAVRAMNIPEGAFSHISTGGGASLEYLEGKTLPGIEVLSREQPTGGVL
Atome Classification :
(64 SA)
.........10........20........30........40........50......-..60........70.----------------..-.-.....80........90........-100-.....-...110.......120.---....--.----.130---------.---.--------......140-------..-----.-----.....-150.......160.......170....---.-.---.-.-180........190.......200.......210.......--220-........230.......-240........250------........260--....----.---.---..270.......280...--.-.-..-290....--....300--.........310.......320.......330.......340.......350.-.......360.....-..370...-....380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
V
A
N
L
K
D
L
L
AEGVSGR
G
V
L
V
RSDLNVPLDEDGTITDAG
R
I
IASA
P
T
L
K
A
L
LDAD
A
K
-
V
V
V
A
AHLGRPKDG-P----------------DP-T-L
S
L
A
P
V
A
V
A
L
G
E
Q
L
G
R
H
V
Q
L
A
GDVV-
G
-
A
-
D
A
L
A
R-AEGLTGG
D
I
L
L
L
ENIRF---DKRE--T----SKN----------
D
---
D
--------
D
R
R
A
L
A
K
Q
--------
L
V
-----
E
-----
L
VGTG-
G
V
F
V
SDGF
G
V
V
H
RKQA
S
V
Y
D
I
-
A
T
L
L
P
---
H
-
Y
---
A
-
G
-
T
-
L
V
A
D
E
M
R
V
L
E
Q
L
T
SSTQR
P
Y
A
V
V
LGGSKV
S
D
K
L
G
V
I
E
S
L
--AT--KA
D
S
I
V
IGG
G
M
C
F
T
F
L
A
A-Q-GF
S
V
G
T
S
L
L
E
D
-------
D
M
I
E
V
C
R
G
L
L
---
E
T
Y
H
----
D
---
V
---
L
RLP
V
D
L
V
V
T
E
K
FAADSP--P-
Q
-
T
V
-DV-GAVP--NG
L
M
G
----
L
DIG
P
G
S
I
K
R
F
S
T
L
L
SNA
G
T
I
F
WNGPMGVFEFPAYAAGT
R
G
V
A
E
A
I
V
AATG-K-
G
A
F
S
V
VGGGDS
A
A
A
V
-
R
A
MNIP
E
G
-
A
F
S
HISTGGGA
S
L
E
YLEGKTLPG
I
E
V
L
SREQPTGGVL
71
HHSearch
96.74
48%
-110
- C9 -
1VPE
3
PGKT_THEMA
A:
[2-397]
--
K
M
T
I
R
D
V
---
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
-
D
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
K
-
V
I
L
L
S
H
L
G
R
P
K
G
E
-
P
----------------
S
P
-
E
-
F
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
P
A
V
V
-
G
-
D
-
E
V
K
K
A
-
V
E
E
L
K
E
G
E
V
L
L
L
E
N
T
R
F
---
H
P
G
E
--
T
----
K
N
D
----------
P
---------------
E
L
A
K
F
--------
W
A
-----
S
-----
L
---
A
-
D
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
-
A
Q
F
I
P
---
S
-
V
---
A
-
G
-
F
-
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
--
M
E
--
K
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
K
E
V
G
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
---
E
K
A
K
----
E
---
K
G
V
E
I
V
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
--
K
-
K
-
V
V
R
I
D
-
D
G
I
P
--
E
G
W
M
G
----
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
A
A
L
T
E
-
K
-
G
A
I
T
V
V
G
G
G
D
S
A
A
A
V
-
N
K
F
G
L
E
-
D
-
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
K
------
6
PsiBlast_PDB
95.16
43%
-113
- C9 -
1PHP
2
PGK_GEOSE
A:
[2-392]
----
N
K
K
T
I
R
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
-
E
Q
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
K
-
V
I
L
A
S
H
L
G
R
P
K
G
K
-
V
----------------
V
E
-
E
-
L
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
E
A
V
-
G
-
D
-
E
V
K
A
A
-
V
D
R
L
N
E
G
D
V
L
L
L
E
N
V
R
F
---
Y
P
G
E
-------
E
K
N
----------
D
---
P
--------
E
---
L
A
K
A
--------
F
A
-----
E
-----
L
---
A
-
D
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
-
A
H
Y
L
P
---
A
-
V
---
A
-
G
-
F
-
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
--
L
E
--
K
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
H
D
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
---
E
K
A
K
----
E
---
K
G
V
R
F
Y
M
P
V
D
V
V
V
A
D
R
F
A
N
D
A
N
--
T
-
K
-
V
V
-
P
I
-
D
A
I
P
--
A
D
W
S
A
----
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
A
E
A
L
----
D
T
Y
S
V
I
G
G
G
D
S
A
A
A
V
-
E
K
F
G
L
A
D
--
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
---------
72
HHSearch
95.13
42%
-117
* C9 *
3Q3V
5
PGK_CAMJE
A:
[6-399]
-
D
I
I
S
I
K
D
I
---
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
S
-
V
I
L
A
S
H
L
G
R
P
K
E
I
------------------
S
S
-
K
-
Y
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
V
M
A
K
D
V
I
-
G
-
E
-
D
A
K
T
K
-
A
M
N
L
K
A
G
E
I
L
L
L
E
N
L
R
F
---
E
K
G
E
--
T
----
K
N
D
----------
E
---------------
N
L
A
K
E
--------
L
A
-----
S
-----
M
---
V
-
Q
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
-
T
K
F
F
D
EKH
K
-
G
---
A
-
G
-
F
-
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
--
L
P
--
K
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
-
L
-
G
Y
D
I
G
N
S
L
L
E
E
-------
E
L
L
E
E
A
N
K
I
L
---
T
K
G
K
----
N
---
L
G
V
K
I
Y
L
P
V
D
V
V
A
A
P
A
C
S
Q
D
V
P
--
M
-
K
-
F
V
-
P
A
-
Q
E
I
P
--
N
G
W
M
G
----
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
S
E
G
-----
H
A
T
S
V
V
G
G
G
D
T
A
D
V
V
-
A
R
A
G
D
A
-
D
-
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
--------
68
HHSearch
94.85
44%
-116
- C9 -
1PHP
2
PGK_GEOSE
A:
[1-393]
M
N
K
K
T
I
R
D
V
---
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
-
Q
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
K
-
V
I
L
A
S
H
L
G
R
P
K
G
K
-
V
----------------
V
E
-
E
-
L
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
E
A
V
-
G
-
D
-
E
V
K
A
A
-
V
D
R
L
N
E
G
D
V
L
L
L
E
N
V
R
F
---
Y
P
G
E
--
E
----
K
N
D
----------
P
---------------
E
L
A
K
A
--------
F
A
-----
E
-----
L
---
A
-
D
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
-
A
H
Y
L
P
---
A
-
V
---
A
-
G
-
F
-
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
--
L
E
--
K
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
H
D
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
---
E
K
A
K
----
E
---
K
G
V
R
F
Y
M
P
V
D
V
V
V
A
D
R
F
A
N
D
A
N
--
T
-
K
-
V
V
-
P
I
-
D
A
I
P
--
A
D
W
S
A
----
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
A
E
A
---
L
-
D
T
Y
S
V
I
G
G
G
D
S
A
A
A
V
-
E
K
F
G
L
A
-
D
-
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
--------
78
HHSearch
94.84
41%
-111
- C9 -
16PK
2
PGKC_TRYBB
A:
[2-414]
--
K
K
S
I
N
E
C
---
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
-
N
G
K
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
E
G
G
S
-
C
V
L
M
S
H
L
G
R
P
K
G
I
-
P
MAQ
A
G
K
I
R
S
T
GGVPGF
Q
Q
-
K
-
A
T
L
K
P
V
A
K
R
L
S
E
L
L
L
R
P
V
T
F
A
P
D
C
L
-
N
----
A
A
D
V
-
V
S
K
M
S
P
G
D
V
V
L
L
E
N
V
R
F
---
Y
K
E
E
--
G
----
S
K
K
----------
A
---
K
--------
D
R
E
A
M
A
K
I
--------
L
A
-----
S
-----
Y
---
G
-
D
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
-
P
K
I
L
G
N
--
G
-
A
---
A
-
G
-
Y
-
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
--
L
Q
--
R
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
-
Q
-
G
Y
S
I
G
K
S
K
C
E
E
-------
S
K
L
E
F
A
R
S
L
L
---
K
K
A
E
----
D
---
R
K
V
Q
V
I
L
P
I
D
H
V
C
H
T
E
F
K
A
V
D
S
--
P
-
L
-
I
T
-
E
D
-
Q
N
I
P
--
E
G
H
M
A
----
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
I
A
K
A
M
G
R
G
T
H
E
H
-
G
L
M
S
I
I
G
G
G
D
S
A
S
A
A
-
E
L
S
G
E
A
-
K
-
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
D
D
--------
73
HHSearch
94.83
49%
-118
- C9 -
1V6S
3
PGK_THET8
A:
[2-390]
---
R
T
L
L
D
L
---
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
-
D
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
S
-
L
V
L
L
S
H
L
G
R
P
K
G
P
------------------
D
P
-
K
-
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
P
-
E
A
R
F
A
P
F
P
P
-
G
S
E
-
E
A
R
R
E
-
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
---
E
P
G
E
--
E
----
K
N
D
----------
P
---------------
E
L
S
A
R
--------
Y
A
-----
R
-----
L
---
G
-
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
-
A
R
L
L
P
---
A
-
Y
---
A
-
G
-
F
-
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
--
L
P
--
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
---
G
R
A
E
----
A
---
L
G
V
R
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
--
T
-
R
-
V
F
-
P
A
-
R
A
I
P
--
V
P
Y
M
G
----
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
A
A
L
---
E
-
G
A
F
T
V
V
G
G
G
D
S
V
A
A
V
-
N
R
L
G
L
K
-
E
-
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
G
--------
11
PsiBlast_PDB
94.81
41%
-116
- C9 -
3Q3V
5
PGK_CAMJE
A:
[7-399]
--
I
I
S
I
K
D
I
---
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
S
-
V
I
L
A
S
H
L
G
R
P
K
E
--
I
----------------
S
S
-
K
-
Y
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
V
M
A
K
D
V
I
-
G
-
E
-
D
A
K
T
K
-
A
M
N
L
K
A
G
E
I
L
L
L
E
N
L
R
F
---
E
K
G
E
--
T
-----
K
N
----------
D
---
E
--------
N
---
L
A
K
E
--------
L
A
-----
S
-----
M
V
Q
----
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
-
T
K
F
F
D
---
E
-
K
H
K
G
A
-
G
-
F
-
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
--
L
P
--
K
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
-
L
-
G
Y
D
I
G
N
S
L
L
E
E
-------
E
L
L
E
E
A
N
K
I
L
---
T
K
G
K
----
N
---
L
G
V
K
I
Y
L
P
V
D
V
V
A
A
P
A
C
S
Q
D
V
P
--
M
-
K
-
F
V
-
P
A
-
Q
E
I
P
--
N
G
W
M
G
----
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
S
E
G
H
-----
A
T
S
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
-
T
F
--
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
--------
1
PsiBlast_PDB
94.65
48%
-112
- C9 -
1VPE
3
PGKT_THEMA
A:
[10-390]
-------------
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
-
K
D
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
K
-
V
I
L
L
S
H
L
G
R
P
K
G
E
-
P
----------------
S
P
-
E
-
F
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
P
A
V
V
-
G
-
D
-
E
V
K
K
A
-
V
E
E
L
K
E
G
E
V
L
L
L
E
N
T
R
F
---
H
P
G
E
--
T
-----
K
N
----------
D
---
P
--------
E
---
L
A
K
F
--------
W
A
-----
S
-----
L
---
A
-
D
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
-
A
Q
F
I
P
---
S
-
V
---
A
-
G
-
F
-
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
--
M
E
--
K
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
K
E
V
G
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
---
E
K
A
K
----
E
---
K
G
V
E
I
V
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
--
K
-
K
-
V
V
-
R
I
D
D
G
I
P
--
E
G
W
M
G
----
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
A
A
L
T
E
-
K
-
G
A
I
T
V
V
G
G
G
D
S
A
A
A
V
-
N
K
F
G
L
-
E
D
-
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
-------------
2
PsiBlast_PDB
94.29
48%
-112
- C9 -
1V6S
3
PGK_THET8
A:
[1-389]
-----
M
R
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
-
Q
D
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
S
-
L
V
L
L
S
H
L
G
R
P
K
-
G
-
P
----------------
D
P
-
K
-
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
P
-
E
A
R
F
A
P
F
P
P
-
G
-
S
-
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
---
E
P
G
E
-------
E
K
N
----------
D
---
P
--------
E
L
S
A
R
Y
A
R
--------
L
----------------
G
-
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
-
A
R
L
L
P
---
A
-
Y
---
A
-
G
-
F
-
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
--
L
P
--
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
L
G
----
V
---
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
--
T
-
R
-
V
F
-
P
A
-
R
A
I
P
--
V
P
Y
M
G
----
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
A
A
L
---
E
-
G
A
F
T
V
V
G
G
G
D
S
V
A
A
V
-
N
R
L
G
L
K
E
--
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
---------
21
PsiBlast_CBE
94.28
48%
-110
- C9 -
1V6S
3
PGK_THET8
B:
[1-389]
-----
M
R
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
-
Q
D
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
S
-
L
V
L
L
S
H
L
G
R
P
K
-
G
-
P
----------------
D
P
-
K
-
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
P
-
E
A
R
F
A
P
F
P
P
-
G
-
S
-
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
---
E
P
G
E
-------
E
K
N
----------
D
---
P
--------
E
L
S
A
R
Y
A
R
--------
L
----------------
G
-
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
-
A
R
L
L
P
---
A
-
Y
---
A
-
G
-
F
-
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
--
L
P
--
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
GRA
E
A
L
G
----
V
---
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
--
T
-
R
-
V
F
-
P
A
-
R
A
I
P
--
V
P
Y
M
G
----
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
A
A
L
---
E
-
G
A
F
T
V
V
G
G
G
D
S
V
A
A
V
-
N
R
L
G
L
K
E
--
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
---------
81
HHSearch
92.86
39%
-113
- C9 -
1QPG
2
PGK_YEAST
A:
[4-414]
-
S
K
L
S
V
Q
D
L
---
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
-
G
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
R
Y
V
V
L
A
S
H
L
G
Q
P
N
G
E
-
R
----------------
N
E
-
K
-
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
-
G
-
P
-
E
V
E
A
A
-
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
---
H
I
E
E
--
E
----
G
S
R
K
V
DGQKVKAS
K
---
E
--------
D
V
Q
K
F
R
H
E
--------
L
S
-----
S
-----
L
---
A
-
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
-
D
--
L
P
Q--
R
-
A
---
A
-
G
-
F
-
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
-
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
---
E
K
A
K
----
A
---
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
T
-
K
-
T
-
V
T
-
D
K
-
E
G
I
P
--
A
G
W
Q
G
----
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
S
S
A
-
A
-
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
-
K
K
Y
G
V
T
-
D
-
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
-------
76
HHSearch
92.82
43%
-113
- C9 -
4FEY
1
PGK_FRATT
A:
[4-392]
M
S
F
L
T
L
K
D
V
---
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
-
D
G
K
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
A
-
V
I
L
M
S
H
L
G
R
P
T
E
G
-
E
Y---------------
D
S
-
Q
-
F
S
L
E
P
V
A
K
A
L
S
E
I
I
N
K
P
V
K
F
A
K
D
W
L
-
D
-
G
--------
V
D
V
K
A
G
E
I
V
M
C
E
N
V
R
F
---
N
S
G
E
--
K
----
K
S
T
----------
D
---------------
D
L
S
K
K
--------
I
A
-----
S
-----
L
---
G
-
D
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
-
A
K
Y
I
P
V
--
A
-
C
---
A
-
G
-
I
-
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
--
L
D
--
K
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
-
E
-
G
F
D
V
G
N
S
L
Y
E
Q
-------
D
L
V
A
E
A
T
E
I
L
---
A
K
A
K
----
A
---
L
GVN
I
P
V
P
V
D
V
R
V
A
K
E
F
S
E
N
A
Q
--
A
-
I
-
I
K
-
K
V
-
S
D
V
V
--
A
D
E
M
I
----
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
L
S
L
A
I
A
Q
----
S
-
H
A
F
S
V
A
G
G
G
D
T
I
A
A
I
-
E
K
F
G
I
K
-
D
-
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
-------
70
HHSearch
92.59
45%
-114
- C9 -
3ZLB
8
PGK_STRP2
A:
[1-398]
M
A
K
L
T
V
K
D
V
---
D
L
K
G
K
K
V
L
V
R
V
D
F
N
V
P
L
K
-
D
G
V
I
T
N
D
N
R
I
T
A
A
L
P
T
I
K
Y
I
I
E
Q
G
G
R
-
A
I
L
F
S
H
L
G
R
V
K
E
E
-
S
D---------------
K
A
-
G
-
K
S
L
A
P
V
A
A
D
L
A
A
K
L
G
Q
D
V
V
F
P
G
V
T
R
-
G
-
A
-
E
L
E
A
A
-
I
N
A
L
E
D
G
Q
V
L
L
V
E
N
T
R
Y
---
E
D
V
D
--
G
KKES
K
N
D
----------
P
---------------
E
L
G
K
Y
--------
W
A
-----
S
-----
L
---
G
D
G
I
F
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
-
S
A
N
V
E
K
--
A
-
V
---
A
-
G
-
F
-
L
L
E
N
E
I
A
Y
I
Q
E
A
V
E
T
P
E
R
P
F
V
A
I
L
G
G
S
K
V
S
D
K
I
G
V
I
E
N
L
--
L
E
--
K
A
D
K
V
L
I
G
G
G
M
T
Y
T
F
Y
K
A
-
Q
-
G
I
E
I
G
N
S
L
V
E
E
-------
D
K
L
D
V
A
K
A
L
L
---
E
K
A
N
----
G
---
K
---
L
I
L
P
V
D
S
K
E
A
N
A
F
A
G
Y
T
E
--
V
-
R
-
D
T
-
E
G
-
E
A
V
S
--
E
G
F
L
G
----
L
D
I
G
P
K
S
I
A
K
F
D
E
A
L
T
G
A
K
T
V
V
W
N
G
P
M
G
V
F
E
N
P
D
F
Q
A
G
T
I
G
V
M
D
A
I
V
K
Q
---
P
-
G
V
K
S
I
I
G
G
G
D
S
A
A
A
A
-
I
N
L
G
R
A
-
D
-
K
F
S
W
I
S
T
G
G
G
A
S
M
E
L
L
E
G
K
V
L
P
G
L
A
A
L
T
E
K
-------
79
HHSearch
92.36
43%
-114
- C9 -
1ZMR
3
PGK_ECOLI
A:
[2-385]
-
S
V
I
K
M
T
D
L
---
D
L
A
G
K
R
V
F
I
R
A
D
L
N
V
P
V
K
-
D
G
K
V
T
S
D
A
R
I
R
A
S
L
P
T
I
E
L
A
L
K
Q
G
A
K
-
V
M
V
T
S
H
L
G
R
P
T
E
G
E
Y
----------------
N
E
-
E
-
F
S
L
L
P
V
V
N
Y
L
K
D
K
L
S
N
P
V
R
L
V
K
D
Y
L
-
D
-
G
--------
V
D
V
A
E
G
E
L
V
V
L
E
N
V
R
F
---
N
K
G
E
--
K
----
K
D
D
----------
E
---------------
T
L
S
K
K
--------
Y
A
-----
A
-----
L
---
C
-
D
V
F
V
M
D
A
F
G
T
A
H
R
A
Q
A
S
T
H
G
I
-
G
K
F
A
D
V
--
A
-
C
---
A
-
G
-
P
-
L
L
A
A
E
L
D
A
L
G
K
A
L
K
E
P
A
R
P
M
V
A
I
V
G
G
S
K
V
S
T
K
L
T
V
L
D
S
L
--
S
K
--
I
A
D
Q
L
I
V
G
G
G
I
A
N
T
F
I
A
A
-
Q
-
G
H
D
V
G
K
S
L
Y
E
A
-------
D
L
V
D
E
A
K
R
L
L
---
T
T
------
C
---
N
---
I
P
V
P
S
D
V
R
V
A
T
E
F
S
E
T
A
P
--
A
-
T
-
L
K
-
S
V
-
N
D
V
K
--
A
D
E
Q
I
----
L
D
I
G
D
A
S
A
Q
E
L
A
E
I
L
K
N
A
K
T
I
L
W
N
G
P
V
G
V
F
E
F
P
N
F
R
K
G
T
E
I
V
A
N
A
I
A
D
----
S
-
E
A
F
S
I
A
G
G
G
D
T
L
A
A
I
-
D
L
F
G
I
A
-
D
-
K
I
S
Y
I
S
T
G
G
G
A
F
L
E
F
V
E
G
K
V
L
P
A
V
A
M
L
E
E
R
A
------
46
PsiBlast_CBE
92.33
41%
-123
- C9 -
1ZMR
3
PGK_ECOLI
A:
[2-383]
-
S
V
I
K
M
T
D
L
---
D
L
A
G
K
R
V
F
I
R
A
D
L
N
V
P
V
-
K
D
G
K
V
T
S
D
A
R
I
R
A
S
L
P
T
I
E
L
A
L
K
Q
G
A
K
-
V
M
V
T
S
H
L
G
R
P
T
E
G
-
E
Y---------------
N
E
-
E
-
F
S
L
L
P
V
V
N
Y
L
K
D
K
L
S
N
P
V
R
L
V
K
D
Y
L
-----
D
G
V
D
V
-
A
E
G
----
E
L
V
V
L
E
N
V
R
F
---
N
K
G
E
--------
K
K
----------
D
---
D
--------
E
--
T
L
S
K
K
--------
Y
A
-----
A
-----
L
C
D
----
V
F
V
M
D
A
F
G
T
A
H
R
A
Q
A
S
T
H
G
I
-
G
K
F
A
D
V
--
A
-
C
---
A
-
G
-
P
-
L
L
A
A
E
L
D
A
L
G
K
A
L
K
E
P
A
R
P
M
V
A
I
V
G
G
S
K
V
S
T
K
L
T
V
L
D
S
L
--
S
K
--
I
A
D
Q
L
I
V
G
G
G
I
A
N
T
F
I
A
A
-
Q
-
G
H
D
V
G
K
S
L
Y
E
A
-------
D
L
V
D
E
A
K
R
L
L
---
T
T
C
N
------------
I
P
V
P
S
D
V
R
V
A
T
E
F
S
E
T
A
P
--
A
-
T
-
L
K
-
S
V
-
N
D
V
K
--
A
D
E
Q
I
----
L
D
I
G
D
A
S
A
Q
E
L
A
E
I
L
K
N
A
K
T
I
L
W
N
G
P
V
G
V
F
E
F
P
N
F
R
K
G
T
E
I
V
A
N
A
I
A
D
S
E
-----
A
F
S
I
A
G
G
G
D
T
L
A
A
I
-
D
L
F
G
I
A
D
--
K
I
S
Y
I
S
T
G
G
G
A
F
L
E
F
V
E
G
K
V
L
P
A
V
A
M
L
E
E
--------
7
PsiBlast_PDB
92.22
41%
-114
- C9 -
4FEY
1
PGK_FRATT
A:
[4-392]
M
S
F
L
T
L
K
D
V
---
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
-
K
D
G
K
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
A
-
V
I
L
M
S
H
L
G
R
P
T
E
G
-
E
Y---------------
D
S
-
Q
-
F
S
L
E
P
V
A
K
A
L
S
E
I
I
N
K
P
V
K
F
A
K
D
W
L
D
G
-
V
-
D
V
K
A
--------
G
E
I
V
M
C
E
N
V
R
F
---
N
S
G
E
--
K
----
K
S
T
----------
D
---
D
------------
L
S
K
K
--------
I
A
-----
S
-----
L
---
G
-
D
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
-
A
K
Y
I
P
V
--
A
-
C
---
A
-
G
-
I
-
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
--
L
D
--
K
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
-
E
-
G
F
D
V
G
N
S
L
Y
E
Q
-------
D
L
V
A
E
A
T
E
I
L
---
A
K
A
K
----
A
---
L
GVN
I
P
V
P
V
D
V
R
V
A
K
E
F
S
E
N
A
Q
--
A
-
I
-
I
K
-
K
V
-
S
D
V
V
--
A
D
E
M
I
----
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
L
S
L
A
I
A
Q
S
H
-----
A
F
S
V
A
G
G
G
D
T
I
A
A
I
-
E
K
F
G
I
K
D
Q
-
V
-
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
-------
10
PsiBlast_PDB
92.03
39%
-110
- C9 -
16PK
2
PGKC_TRYBB
A:
[10-412]
-------------
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
-
K
N
G
K
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
E
G
G
S
-
C
V
L
M
S
H
L
G
R
P
K
G
I
-
P
MAQ
A
G
K
I
R
S
T
GGVPGF
Q
Q
-
K
-
A
T
L
K
P
V
A
K
R
L
S
E
L
L
L
R
P
V
T
F
A
P
D
C
L
-
N
-
A
A
D
V
V
S
K
----
M
S
P
G
D
V
V
L
L
E
N
V
R
F
---
Y
K
E
E
--
G
----
S
K
K
----------
A
---
K
--------
D
R
E
A
M
A
K
I
--------
L
A
-----
S
-----
Y
---
G
-
D
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
-
P
K
I
L
G
---
N
G
A
---
A
-
G
-
Y
-
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
--
L
Q
--
R
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
-
Q
-
G
Y
S
I
G
K
S
K
C
E
E
-------
S
K
L
E
F
A
R
S
L
L
---
K
K
A
E
----
D
R
K
V
Q
---
V
I
L
P
I
D
H
V
C
H
T
E
F
K
A
V
D
S
--
P
-
L
-
I
T
-
E
D
-
Q
N
I
P
--
E
G
H
M
A
----
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
I
A
K
A
M
G
R
G
T
H
-
E
H
G
L
M
S
I
I
G
G
G
D
S
A
S
A
A
-
E
-
L
S
G
E
A
K
-
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
----------
3
PsiBlast_PDB
91.63
49%
-112
- C9 -
2IE8
-
?
A:
[10-389]
--------------
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
-
Q
D
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
S
-
L
V
L
L
S
H
L
G
R
P
K
-
G
-
P
----------------
D
P
-
R
-
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
P
-
E
A
R
F
A
P
F
P
P
-
G
-
S
-
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
---
E
P
G
E
-------
E
K
N
----------
D
---
P
--------
E
L
S
A
R
Y
A
R
--------
L
----------------
G
-
E
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
-
A
R
L
L
P
---
A
-
Y
---
A
-
G
-
F
-
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
--
L
P
--
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
L
G
----
V
---
R
---
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
--
T
-
R
-
V
F
-
P
A
-
R
A
I
P
--
V
P
Y
M
G
----
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
A
A
L
---
E
-
G
A
F
T
V
V
G
G
G
D
S
V
A
A
V
-
N
R
L
G
L
K
E
--
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
---------
69
HHSearch
91.23
43%
-120
- C9 -
4DG5
-
PGK_STAAR
A:
[3-396]
--
K
K
I
V
S
D
L
---
D
L
K
G
K
T
V
L
V
R
A
D
F
N
V
P
L
K
-
D
G
E
I
T
N
D
N
R
I
V
Q
A
L
P
T
I
Q
Y
I
I
E
Q
G
G
K
-
I
V
L
F
S
H
L
G
K
V
K
E
E
-
S
D---------------
K
A
-
K
-
L
T
L
R
P
V
A
E
D
L
S
K
K
L
D
K
E
V
V
F
V
P
E
T
R
-
G
-
E
-
K
L
E
A
A
-
I
K
D
L
K
E
G
D
V
L
L
V
E
N
T
R
Y
---
E
D
L
D
--
G
KKES
K
N
D
----------
P
---------------
E
L
G
K
Y
--------
W
A
-----
S
-----
L
---
G
-
D
V
F
V
N
D
A
F
G
T
A
H
R
E
H
A
S
N
V
G
I
-
S
T
H
L
E
---
T
-
A
---
A
-
G
-
F
-
L
M
D
K
E
I
K
F
I
G
G
V
V
N
D
P
H
K
P
V
V
A
I
L
G
G
A
K
V
S
D
K
I
N
V
I
K
N
L
--
V
N
--
I
A
D
K
I
I
I
G
G
G
M
A
Y
T
F
L
K
A
-
Q
-
G
K
E
I
G
I
S
L
L
E
E
-------
D
K
I
D
F
A
K
D
L
L
---
E
K
H
G
----
D
---
K
---
I
V
L
P
V
D
T
K
V
A
K
E
F
S
N
D
A
K
--
I
-
T
-
V
V
-
P
S
-
D
S
I
P
--
A
D
Q
E
G
----
M
D
I
G
P
N
T
V
K
L
F
A
D
E
L
E
G
A
H
T
V
V
W
N
G
P
M
G
V
F
E
F
S
N
F
A
Q
G
T
I
G
V
C
K
A
I
A
N
L
---
K
-
D
A
I
T
I
I
G
G
G
D
S
A
A
A
A
-
I
S
L
G
F
E
-
N
-
D
F
T
H
I
S
T
G
G
G
A
S
L
E
Y
L
E
G
K
E
L
P
G
I
K
A
I
N
N
K
-------
5
PsiBlast_PDB
91.18
45%
-114
- C9 -
3ZLB
8
PGK_STRP2
A:
[11-398]
-------------
L
K
G
K
K
V
L
V
R
V
D
F
N
V
P
L
-
K
D
G
V
I
T
N
D
N
R
I
T
A
A
L
P
T
I
K
Y
I
I
E
Q
G
G
R
-
A
I
L
F
S
H
L
G
R
V
K
E
E
-
S
----------------
D
K
-
A
G
K
S
L
A
P
V
A
A
D
L
A
A
K
L
G
Q
D
V
V
F
P
G
V
T
R
-
G
-
A
-
E
L
E
A
A
-
I
N
A
L
E
D
G
Q
V
L
L
V
E
N
T
R
Y
EDV
D
G
K
K
--
E
----
S
K
N
----------
D
---
P
--------
E
---
L
G
K
Y
--------
W
A
-----
S
-----
L
--
G
D
-
G
I
F
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
S
A
N
V
E
K
---
A
-
V
---
A
-
G
-
F
-
L
L
E
N
E
I
A
Y
I
Q
E
A
V
E
T
P
E
R
P
F
V
A
I
L
G
G
S
K
V
S
D
K
I
G
V
I
E
N
L
--
L
E
--
K
A
D
K
V
L
I
G
G
G
M
T
Y
T
F
Y
K
A
-
Q
-
G
I
E
I
G
N
S
L
V
E
E
-------
D
K
L
D
V
A
K
A
L
L
---
E
K
A
N
----
G
---
K
---
L
I
L
P
V
D
S
K
E
A
N
A
F
A
G
Y
T
E
--
V
-
R
-
D
T
-
E
G
-
E
A
V
S
--
E
G
F
L
G
----
L
D
I
G
P
K
S
I
A
K
F
D
E
A
L
T
G
A
K
T
V
V
W
N
G
P
M
G
V
F
E
N
P
D
F
Q
A
G
T
I
G
V
M
D
A
I
V
K
Q
P
----
G
V
K
S
I
I
G
G
G
D
S
A
A
A
---
A
I
N
L
G
R
A
D
K
F
S
W
I
S
T
G
G
G
A
S
M
E
L
L
E
G
K
V
L
P
G
L
A
A
L
T
E
K
-------
23
PsiBlast_CBE
90.91
37%
-123
- C9 -
4NG4
2
PGK_COXBU
B:
[15-399]
L
S
M
S
N
L
------
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
-
K
N
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
R
-
V
M
I
L
S
H
L
G
R
P
E
E
G
-
K
F---------------
E
K
-
E
-
F
S
L
A
P
V
A
R
L
L
S
K
K
L
N
-
K
V
P
L
I
N
D
W
L
---------
K
-
G
V
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
---
N
K
G
E
--
N
----
E
N
N
----------
T
---
E
------------
L
A
K
R
--------
M
A
-----
E
-----
L
C
D
----
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
-
A
A
Y
A
K
L
--
A
-
C
---
A
-
G
-
P
-
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
--
L
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
---
E
K
A
A
----
E
K
NV
S
---
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
--
A
-
T
-
V
K
-
N
I
-
D
A
V
T
--
S
N
E
S
I
----
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
A
K
S
T
-----
A
Y
S
I
V
G
G
G
D
T
L
A
A
L
-
D
K
F
N
L
T
D
--
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
I
L
P
A
I
K
I
L
T
Q
--------
22
PsiBlast_CBE
90.33
37%
-125
- C9 -
4NG4
2
PGK_COXBU
C:
[15-399]
L
S
M
S
N
L
------
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
-
K
N
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
R
-
V
M
I
L
S
H
L
G
R
P
E
E
G
-
K
F---------------
E
K
-
E
-
F
S
L
A
P
V
A
R
L
L
S
K
K
L
N
--
V
P
L
I
N
D
W
L
---------
K
-
G
V
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
---
N
K
G
E
--
N
----
E
N
N
----------
T
---
E
------------
L
A
K
R
--------
M
A
-----
E
-----
L
C
D
----
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
-
A
A
Y
A
K
L
--
A
-
C
---
A
-
G
-
P
-
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
--
L
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
---
E
K
A
A
----
E
K
NV
S
---
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
--
A
-
T
-
V
K
-
N
I
-
D
A
V
T
--
S
N
E
S
I
----
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
A
K
S
T
-----
A
Y
S
I
V
G
G
G
D
T
L
A
A
L
-
D
K
F
N
L
T
D
--
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
--
L
P
A
I
K
I
L
T
Q
--------
12
PsiBlast_PDB
89.28
38%
-102
- C9 -
2XE6
1
PGK1_HUMAN
A:
[5-416]
----
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
77
HHSearch
89.23
39%
-114
- C9 -
4NG4
2
PGK_COXBU
A:
[14-401]
--
F
L
S
M
S
N
L
---
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
-
N
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
R
-
V
M
I
L
S
H
L
G
R
P
E
E
G
-
K
F---------------
E
K
-
E
-
F
S
L
A
P
V
A
R
L
L
S
K
K
-----
P
L
I
N
D
W
L
-
K
-
G
-
V
-------
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
---
N
K
G
E
--
N
----
E
N
N
----------
T
---------------
E
L
A
K
R
--------
M
A
-----
E
-----
L
---
C
-
D
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
-
A
A
Y
A
K
L
--
A
-
C
---
A
-
G
-
P
-
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
--
L
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
---
E
K
A
A
----
E
---
K
NV
S
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
--
A
-
T
-
V
K
-
N
I
-
D
A
V
T
--
S
N
E
S
I
----
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
A
K
S
-----
T
A
Y
S
I
V
G
G
G
D
T
L
A
A
L
-
D
K
F
N
L
T
-
D
-
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
-
L
P
A
I
K
I
L
T
Q
R
A
------
48
PsiBlast_CBE
89.00
38%
-113
- C9 -
1QPG
2
PGK_YEAST
A:
[16-415]
----------------
K
R
V
F
I
R
V
D
F
N
V
P
L
D
-
G
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
R
Y
V
V
L
A
S
H
L
G
Q
P
N
G
E
-
R
----------------
N
E
-
K
-
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
-
G
-
P
-
E
V
E
A
A
-
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
---
H
I
E
E
EG
S
----
R
K
V
----------
D
---
G
--------
Q
K
V
K
A
S
K
E
--------
D
V
Q
K
F
R
H
E
-----
L
S
S
L
A
-
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
F
D
L
P
---
Q
-
R
---
A
A
G
-
F
-
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
---
E
K
A
K
A
K
G
V
E
---
V
---
V
-
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
--
T
-
K
-
T
V
T
D
K
-
E
G
I
P
--
A
G
W
Q
G
----
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
S
S
A
-
A
-
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
-
K
K
Y
G
V
T
D
--
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
------
75
HHSearch
88.99
40%
-107
- C9 -
2WZB
5
PGK1_HUMAN
A:
[3-415]
S
N
K
L
T
L
D
K
L
---
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
M---------------
P
D
-
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
E---------
P
---
A
--------
K
I
E
A
F
R
A
S
--------
L
S
-----
K
-----
L
---
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
-
N
--
L
P
Q
--
K
-
A
---
G
-
G
-
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
---
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
E
-
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
36
PsiBlast_CBE
88.93
38%
-101
- C9 -
4O33
2
PGK1_HUMAN
A:
[1-416]
M
S
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
T
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
47
PsiBlast_CBE
88.89
38%
-104
- C9 -
1HDI
3
PGK1_PIG
A:
[10-412]
-------------
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
A
A
-
A
Q
I
T
N
N
A
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
S
-
P
----------------
M
P
D
K
-
Y
S
L
Q
P
V
A
A
E
L
K
S
A
L
G
K
A
V
L
F
L
K
D
C
V
-
G
-
P
-
A
V
E
K
A
-
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG
N
K
A
A
G
E
P
A
K
I
K
A
F
--------
R
A
-----
S
-----
L
S
A
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
K
-
K
---
A
-
G
-
A
F
L
M
K
K
E
L
N
Y
F
A
A
A
A
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
A
G
K
K
I
V
K
N
L
M
---
S
K
A
A
----
A
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
Q
A
K
--
I
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
K
S
S
A
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
N
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
14
PsiBlast_PDB
88.79
38%
-100
- C9 -
2XE8
2
PGK1_HUMAN
A:
[5-416]
----
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
18
PsiBlast_PDB
88.65
38%
-102
- C9 -
1KF0
3
PGK1_PIG
A:
[1-415]
-
S
L
S
N
K
L
T
L
D
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
S
-
P
----------------
M
P
D
K
-
Y
S
L
Q
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG
N
K
V
K
A
E
P
A
K
I
K
T
F
--------
R
A
-----
S
-----
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
K
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
N
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
H
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
53
PsiBlast_CBE
88.52
37%
-107
- C9 -
2P9T
1
PGK2_MOUSE
A:
[13-415]
-------------
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
I
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
V
-
G
-
P
-
E
V
E
Q
A
-
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
SSG
K
K
I
S
A
D
P
A
K
V
E
A
F
--------
R
A
-----
S
-----
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
S
G
-
F
-
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
--
L
D
--
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
---
E
K
A
E
----
K
N
G
V
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
V
G
Q
-
A
-
T
I
-
E
S
-
G
-
I
P
--
S
G
W
M
G
----
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
N
-
G
C
V
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
G
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
--------
8
PsiBlast_PDB
88.45
37%
-120
- C9 -
4NG4
2
PGK_COXBU
A:
[15-399]
L
S
M
S
N
L
------
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
-
K
N
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
R
-
V
M
I
L
S
H
L
G
R
P
E
E
G
-
K
F---------------
E
K
-
E
-
F
S
L
A
P
V
A
R
L
L
S
K
K
-----
P
L
I
N
D
W
L
---------
K
-
G
V
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
---
N
K
G
E
--
N
----
E
N
N
----------
T
---
E
------------
L
A
K
R
--------
M
A
-----
E
-----
L
C
D
----
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
-
A
A
Y
A
K
L
--
A
-
C
---
A
-
G
-
P
-
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
--
L
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
---
E
K
A
A
----
E
K
NV
S
---
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
--
A
-
T
-
V
K
-
N
I
-
D
A
V
T
--
S
N
E
S
I
----
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
A
K
S
T
-----
A
Y
S
I
V
G
G
G
D
T
L
A
A
L
-
D
K
F
N
L
T
D
--
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
-
L
P
A
I
K
I
L
T
Q
--------
38
PsiBlast_CBE
88.36
38%
-106
- C9 -
1VJC
1
PGK1_PIG
A:
[13-415]
-------------
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
I
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG
S
K
V
K
A
D
P
A
K
I
E
A
F
--------
R
A
-----
S
-----
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
K
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
13
PsiBlast_PDB
88.30
38%
-98
- C9 -
2XE7
2
PGK1_HUMAN
A:
[5-416]
----
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
GV
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
19
PsiBlast_PDB
87.88
38%
-106
- C9 -
2ZGV
1
PGK1_HUMAN
A:
[6-419]
--
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
--------------
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
45
PsiBlast_CBE
87.84
37%
-101
- C9 -
4O3F
2
PGK1_MOUSE
A:
[1-416]
M
S
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
A
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
N
A
-
C
A
N
P
A
A
G
T
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
--------
A
S
G
N
K
V
K
A
E
P
A
K
I
D
A
F
R
A
-----
S
-----
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
Y
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
T
E
S
S
K
K
Y
A
E
A
V
G
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
S
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
----------
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
34
PsiBlast_CBE
87.83
38%
-103
- C9 -
3C3A
1
PGK1_HUMAN
A:
[6-419]
--
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
----------
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
37
PsiBlast_CBE
87.72
38%
-106
- C9 -
1VJD
2
PGK1_PIG
A:
[13-415]
-------------
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
I
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG
S
K
V
K
A
D
P
A
K
I
E
A
F
--------
R
A
-----
S
-----
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
K
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
17
PsiBlast_PDB
87.67
38%
-99
- C9 -
2Y3I
5
PGK1_HUMAN
A:
[3-416]
--
M
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
30
PsiBlast_CBE
87.63
38%
-103
- C9 -
3C3C
3
PGK1_HUMAN
A:
[5-419]
-
S
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
---------------
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
52
PsiBlast_CBE
87.53
37%
-106
- C9 -
2PAA
1
PGK2_MOUSE
A:
[13-415]
-------------
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
I
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
V
-
G
-
P
-
E
V
E
Q
A
-
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
SSG
K
K
I
S
A
D
P
A
K
V
E
A
F
--------
R
A
-----
S
-----
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
S
G
-
F
-
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
--
L
D
--
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
---
E
K
A
E
----
K
N
G
V
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
V
G
Q
-
A
-
T
I
-
E
S
-
G
-
I
P
--
S
G
W
M
G
----
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
N
-
G
C
V
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
G
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
--------
27
PsiBlast_CBE
87.51
38%
-102
- C9 -
4AXX
5
PGK1_HUMAN
A:
[3-416]
--
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
----------------
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
16
PsiBlast_PDB
87.39
38%
-101
- C9 -
3ZOZ
5
PGK1_HUMAN
A:
[3-416]
--
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------------------------
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
43
PsiBlast_CBE
87.30
38%
-101
- C9 -
2WZD
5
PGK1_HUMAN
A:
[3-416]
--
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------------------------
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
15
PsiBlast_PDB
87.20
38%
-102
- C9 -
2YBE
5
PGK1_HUMAN
A:
[3-416]
--
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
-------------
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
20
PsiBlast_PDB
86.99
38%
-107
- C9 -
3C39
1
PGK1_HUMAN
A:
[5-419]
-
S
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---------------
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
---------------
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
28
PsiBlast_CBE
86.84
38%
-100
- C9 -
2Y3I
5
PGK1_HUMAN
D:
[3-416]
--
M
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
AFRAS
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
NGV
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
31
PsiBlast_CBE
86.34
38%
-109
- C9 -
3C3B
2
PGK1_HUMAN
B:
[6-419]
--
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-------
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
---------------
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
39
PsiBlast_CBE
86.10
38%
-106
- C9 -
2X15
3
PGK1_HUMAN
A:
[13-415]
-------------
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---------------
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
51
PsiBlast_CBE
85.94
37%
-111
- C9 -
2PAA
1
PGK2_MOUSE
B:
[13-415]
-------------
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
I
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
V
-
G
-
P
-
E
V
E
Q
A
-
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
SSGKKISA
D
P
A
K
V
E
A
F
--------
R
A
-----
S
-----
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
S
G
-
F
-
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
--
L
D
--
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
---
E
K
A
E
----
K
NGV
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
VG
Q
-
A
-
T
I
-
E
S
-
G
-
I
P
--
S
G
W
M
G
----
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
N
-
G
C
V
T
I
I
G
------------------
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
--------
33
PsiBlast_CBE
85.83
38%
-105
- C9 -
3C3A
3
PGK1_HUMAN
B:
[6-419]
--
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
--------
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
AS
G
-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
--------------
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
29
PsiBlast_CBE
85.56
38%
-105
- C9 -
3C3C
1
PGK1_HUMAN
B:
[6-419]
--
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-------
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
AS
G
-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
---------------
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
40
PsiBlast_CBE
85.54
38%
-105
- C9 -
2X13
3
PGK1_HUMAN
A:
[13-415]
-------------
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---------------
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
44
PsiBlast_CBE
85.52
38%
-104
- C9 -
2X14
3
PGK1_HUMAN
A:
[13-415]
-------------
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------------------------
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
41
PsiBlast_CBE
85.36
38%
-105
- C9 -
2WZC
5
PGK1_HUMAN
A:
[13-415]
-------------
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------------------------
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
42
PsiBlast_CBE
85.22
38%
-105
- C9 -
2WZB
5
PGK1_HUMAN
A:
[13-415]
-------------
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
-
G
-
P
-
E
V
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------------------------
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
-
A
K
W
N
T
-
E
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
74
HHSearch
84.44
33%
-98
- C9 -
2CUN
5
PGK_PYRHO
A:
[2-404]
---
F
R
L
E
D
F
---
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
-
D
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
K
-
V
V
I
G
T
H
Q
G
K
P
Y
S
E
-------------------
D
-
Y
-
T
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
F
-
G
-
R
-
Y
A
R
E
K
-
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
---
S
A
E
E
--
V
----
K
N
K
----------
P
I
E
E
C
--------
E
K
T
F
L
V
K
K
--------
L
S
-----
K
-----
V
---
I
-
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
-
A
R
I
K
P
---
M
-
I
---
M
-
G
-
F
-
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
--
L
R
R
E
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
F
D
L
G
R
K
N
V
E
F
M
K
K
K
GLL
D
Y
V
K
H
A
E
E
I
L
---
D
E
F
Y
----
P
---
Y
---
I
R
T
P
V
D
F
A
V
D
Y
K
G
E
R
V
E
I
--
D
-
L
-
L
S
-
E
N
-
R
G
L
L
--
H
Q
Y
Q
I
----
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
A
D
-
S
----
P
A
F
S
V
L
G
G
G
H
S
I
A
S
I
-
Q
K
Y
G
I
--
T
-
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
Y
E
K
----
35
PsiBlast_CBE
83.94
38%
-105
- C9 -
3C39
1
PGK1_HUMAN
B:
[6-419]
--
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
K
N
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
G
V
-
P
----------------
M
P
D
K
-
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
---------
E
K
A
-
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
---
H
V
E
E
--
E
----
G
K
G
----------
K
---
D
ASG-----
N
K
V
K
A
E
P
A
--------
K
I
-----
E
A
F
R
A
S
L
S
K
L
G
-
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
V
N
L
P
---
Q
-
K
---
A
-
G
G
F
-
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
--
L
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
---
S
K
A
E
----
K
N
G
V
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
--
T
G
Q
-
A
T
-
V
A
-
S
G
I
P
--
A
G
W
M
G
----
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
T
S
-
R
-
G
C
I
T
I
I
G
G
---------------
D
-
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--------
57
PsiBlast_CBE
81.26
32%
-104
- C9 -
2CUN
5
PGK_PYRHO
A:
[8-399]
------------
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
-
K
D
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
K
-
V
V
I
G
T
H
Q
G
K
P
Y
-
S
-
E
----------------
D
Y
-
T
-
T
T
-
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
F
-
G
-
R
-
Y
A
R
E
K
-
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
---
S
A
E
E
--
V
----
K
N
K
P
I
E
-------
E
---
C
--------
E
K
T
F
L
V
K
K
--------
L
S
-----
K
-----
V
I
D
----
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
-
A
R
I
K
P
---
M
-
I
---
M
-
G
-
F
-
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
R
R
E
--
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
F
D
L
G
R
K
N
V
E
F
M
K
K
K
GLL
D
Y
V
K
H
A
E
E
I
L
---
D
E
F
Y
----
P
---
Y
---
I
R
T
P
V
D
------
F
A
V
D
Y
K
--
G
-
E
-
R
V
-
E
I
-
D
L
L
S
EN
R
G
L
L
H
Q
Y
QI
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
A
D
S
P
-----
A
F
S
V
L
G
G
G
H
S
I
A
S
I
-
Q
K
Y
G
I
T
---
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
---------
56
PsiBlast_CBE
80.71
32%
-102
- C9 -
2CUN
5
PGK_PYRHO
B:
[8-399]
------------
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
-
K
D
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
K
-
V
V
I
G
T
H
Q
G
K
P
Y
-
S
-
E
----------------
D
Y
-
T
-
T
T
-
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
F
-
G
-
R
-
Y
A
R
E
K
-
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
---
S
A
E
E
--
V
----
K
N
K
PIE-------
E
---
C
--------
E
K
T
F
L
V
K
K
--------
L
S
-----
K
-----
V
I
D
----
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
-
A
R
I
K
P
---
M
-
I
---
M
-
G
-
F
-
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
LR
R
E
--
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
F
D
L
G
R
K
N
V
E
F
MKKKGLL
D
Y
V
K
H
A
E
E
I
L
---
D
E
F
Y
----
P
---
Y
---
I
R
T
P
V
D
------
F
A
V
D
Y
K
--
G
-
E
-
R
V
-
E
I
-
D
L
L
S
EN
R
G
L
L
H
QYQI
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
A
D
S
P
-----
A
F
S
V
L
G
G
G
H
S
I
A
S
I
-
Q
K
Y
G
I
T
---
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
---------
83
HHSearch
78.69
38%
-99
- C9 -
1FW8
5
PGK_YEAST
A:
[1-348]
------------------------------------------------------------------------------------------
S
-
K
-
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
-
G
-
P
-
E
V
E
A
A
-
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
---
H
I
E
E
--
E
----
G
S
R
K
V
DG
Q
K
V
K
A
S
K
---
E
--------
D
V
Q
K
F
R
H
E
--------
L
S
-----
S
-----
L
---
A
-
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
-
D
--
L
P
Q--
R
-
A
---
A
-
G
-
F
-
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
-
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
---
E
K
A
K
----
A
---
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
--
T
-
K
T
V
T
-
D
K
-
E
G
I
P
--
A
G
W
Q
G
----
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
S
S
A
-
A
-
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
-
K
K
Y
G
V
T
-
D
-
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
S
L
S
S
--
55
PsiBlast_CBE
77.06
38%
-103
- C9 -
1FW8
4
PGK_YEAST
A:
[4-344]
-----------------------------------------------------------------------------------------------
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
-
G
-
P
-
E
V
E
A
A
-
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
---
H
I
E
E
EG
S
----
R
K
V
----------
D
---
G
--------
Q
K
V
K
A
S
K
E
--------
D
V
Q
K
F
R
H
E
-----
L
S
S
L
A
-
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
F
D
L
P
---
Q
-
R
---
A
A
G
-
F
-
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
---
E
K
A
K
A
K
G
V
E
---
V
---
V
-
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
--
T
-
K
-
T
V
T
D
K
-
E
G
I
P
--
A
G
W
Q
G
----
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
S
S
A
-
A
-
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
-
K
K
Y
G
V
T
D
--
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
------
54
PsiBlast_CBE
65.49
38%
-10
- C9 -
3PGK
3
PGK_YEAST
A:
[19-416]
----------------
K
R
V
F
I
R
V
D
F
N
V
P
L
D
-
G
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
R
Y
V
V
L
A
S
H
L
G
R
P
N
G
E
-
R
----------------
N
E
-
K
-
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
-
G
-
P
-
E
V
E
A
A
-
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
---
H
I
E
E
EG
S
----
R
K
V
----------
D
---
G
--------
Q
K
V
K
A
S
K
E
--------
D
V
Q
K
F
R
H
E
-----
L
S
S
L
A
-
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
--
V
-
G
F
D
L
P
---
Q
-
R
---
A
A
G
-
F
-
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
--
L
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
T
E
I
G
D
S
I
F
D
K
-------
A
V
G
P
E
I
A
K
L
M
---
E
K
A
K
A
K
G
V
E
---
V
---
V
-
L
P
V
D
F
I
I
A
D
A
F
S
A
S
A
N
--
T
-
K
-
T
V
T
D
K
-
E
G
I
P
--
A
G
W
Q
G
----
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
T
V
I
L
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
S
S
A
-
A
-
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
-
K
K
Y
G
V
T
D
--
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
------
84
HHSearch
39.82
42%
-88
- C9 -
1FW8
2
PGK_YEAST
A:
[349-413]
--
K
L
S
V
Q
D
L
---
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
R
Y
V
V
L
A
S
H
L
G
R
P
N
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------