@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1458c: (2016-05-02 )
MNRAPDTPEVVLRLRGVCKRYGSITAVSNLDLDVHDAEVMALLGPNGAGKTTTVEMCEGFVRPDAGSIEVLGLDPITDNARLRARIGVMLQGGGGYPAARAGEMLDLVASYAANPLDPHWLLDTLGLTEAARTTYRRLSGGQQQRLALACALVGRPQLVFLDEPTAGMDAHARVLVWELIDALRRDGVTVVLTTHHLKEAEELADRLVIIDHGVTVAAGTPAELMRSGAKDQLRFTAPPRLDLSLLASALPEGYQATELTPGEYLVEGPVDPQVLATVTAWCAQIDVLATDMRVEQRSLEDVFLDLTGRKLRQ
Atome Classification :
(21 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20-.----.-----.--.....30........40........50........60........70.----.---.----...-.---.80-..-----------------.......90.--------..-.....100.....----..110----....-----..-----.-----.--120---....--...-.130.......140.......150.......160.......170----.......180.-.---.-.-...190.......200.......210.......220.......230..-...--------..240.......250.......260.......270....----...280.....--------..290.......300.......310.--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNRAPD
T
P
E
V
V
L
R
L
R
G
V
C
K
RY-G----S-----
I
--
T
A
V
S
NL
D
L
DVHD
A
E
V
M
A
L
LGPNGAGKT
T
T
V
E
M
C
E
G
FVRPDAG
S
I
E
V
L
G----L---D----PIT-D---NA--
R
L
-----------------
R
A
R
I
G
V
M
L
QG--------GG-GYPA
A
R
A
G
E
M
L
D
L
----
V
A
S
Y-----AANP-----L
D
-----
P
-----
H
--
W
L
----
L
D
TL--G
L
T
-
E
A
A
R
T
T
Y
R
RLSGG
Q
Q
Q
R
L
A
L
A
C
A
LVGR
P
Q
L
V
F
L
DEPTAG
M
D
A
H
A
----
R
V
L
V
W
E
L
I
D
A
L
-
R
---R-D-
G
V
T
V
V
L
T
T
H
H
L
K
E
A
E
E
LAD
R
L
V
I
I
DHG
V
T
VAAG
T
P
A
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L
M
RSGAKD
Q
L
R
-FTA--------PPRL
D
L
S
L
L
A
S
ALPEGYQATELTPG
E
Y
L
VEGPV
D
P
Q
V
L
A
----
T
V
T
A
W
C
A
Q
I
D
V
--------LATD
M
R
V
E
Q
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LTGRKLRQ--
18
PsiBlast_PDB
77.27
28%
-108
- C1 -
1Q12
2
MALK_ECOLI
A:
[4-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
Q
N
V
T
K
A
W
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G
----
E
-----
V
--
V
V
S
K
D
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V
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P
S
G
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L
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L
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T
I
T
S
G
D
L
-
F
I
G
----
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K
----
R
M
N
-
D
---
T
P
--
P
A
-----------------
E
R
G
V
G
M
V
F
Q
S
--------
Y
A
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L
Y
P
H
L
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V
A
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F
----
G
L
K
L
-----
A
G
A
K
-----
K
E
VI
N
Q
R
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-----
N
--
Q
V
----
A
E
V
L
--
Q
L
A
-
H
L
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G
Q
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R
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I
S
R
L
H
K
---
R
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T
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A
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A
D
R
F
V
A
G
F
I
G
--------
S
P
K
M
N
F
------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.34
33%
-116
- C1 -
4WBS
1
?
B:
[30-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
K
P
A
G
T
S
S
S
L
V
V
R
N
L
K
K
R
Y
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G
----
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-----
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--
T
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V
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D
V
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L
---
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----
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K
---
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A
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L
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L
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V
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E
N
I
R
A
V
L
E
L
--------
Q
V
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G
--
G
K
R
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K
--
D
A
----
I
A
S
R
-----
T
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E
--
A
L
----
L
D
E
L
--
Q
I
S
-
H
L
R
E
N
P
A
L
S
L
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G
G
E
R
R
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V
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I
A
R
A
L
A
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N
P
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L
D
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F
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G
V
D
P
I
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----
V
L
E
I
Q
K
I
V
K
F
L
-
K
---
Q
-
R
-
N
I
G
V
L
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T
D
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N
V
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E
T
L
G
I
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D
G
S
V
L
A
A
G
A
P
G
D
I
I
E
N
-------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
76.00
28%
-112
- C1 -
1Q1E
-
MALK_ECOLI
A:
[4-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
Q
N
V
T
K
A
W
-
G
----
E
-----
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-
F
I
G
----
E
---
K
----
R
M
N
-
D
---
T
P
--
P
A
-----------------
E
R
G
V
G
M
V
F
Q
S
--------
Y
A
-
L
Y
P
H
L
S
V
A
E
N
M
S
F
----
G
L
K
L
-----
A
G
A
K
-----
K
E
V
I
N
Q
R
V
-----
N
--
Q
V
----
A
E
V
L
--
Q
L
A
-
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
----
R
V
Q
M
R
I
E
I
S
R
L
H
K
---
R
-
L
-
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
--------
S
P
K
M
N
F
------------------------------------------------------------------------------------
17
PsiBlast_PDB
75.48
28%
-110
- C1 -
1Q1B
-
MALK_ECOLI
A:
[4-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
Q
N
V
T
K
A
W
-
G
----
E
-----
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-
F
I
G
----
E
---
K
----
R
M
N
-
D
---
T
P
--
P
A
-----------------
E
R
G
V
G
M
V
F
Q
S
--------
Y
A
-
L
Y
P
H
L
S
V
A
E
N
M
S
F
----
G
L
K
L
-----
A
G
A
K
-----
K
E
V
I
N
Q
R
V
-----
N
--
Q
V
----
A
E
V
L
--
Q
L
A
-
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
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P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
----
R
V
Q
M
R
I
E
I
S
R
L
H
K
---
R
-
L
-
G
R
T
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Y
V
T
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V
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A
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A
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G
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P
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Y
H
Y
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A
D
R
F
V
A
G
F
I
G
--------
S
P
K
M
N
F
------------------------------------------------------------------------------------
60
Fugue
75.17
22%
-104
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
-
H
QGTR
T
-----
I
--
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
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Y
G
V
I
G
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L
L
E
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----
Q
---
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LTTL
S
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---
L
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--
K
A
-----------------
R
R
Q
I
G
M
I
F
Q
H
--------
F
N
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L
L
S
S
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N
V
A
L
----
P
L
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L
DNTPK
D
E
V
K
-----
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-----
T
--
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L
----
L
S
L
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--
G
L
G
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D
S
Y
P
S
N
L
S
G
G
Q
K
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R
V
A
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A
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A
L
A
S
N
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V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
----
T
R
S
I
L
E
L
L
K
D
I
-
N
---
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
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C
D
C
V
A
V
I
S
N
G
E
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F
S
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P
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Y
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T
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D
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S
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RFNV
N
N
N
I
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A
Q
M
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AGGVKFGI
M
L
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D
T
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A
A
I
A
W
L
Q
E
H
H
V
K
V
EV
15
PsiBlast_PDB
75.16
30%
-108
- C1 -
4U02
1
?
A:
[2-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
I
I
R
I
R
N
L
H
K
W
F
-
G
----
P
-----
L
--
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
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G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
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F
Q
E
G
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V
V
V
D
G
----
L
---
S
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D
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---
R
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R
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V
G
M
V
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--------
F
N
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V
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S
A
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M
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G
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V
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D
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R
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L
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G
M
T
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V
V
T
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G
F
A
R
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A
D
R
V
V
F
M
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G
G
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G
R
P
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I
F
T
R
P
K
E
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R
T
R
------------------------------------------------------------------------------------------------------
69
HHSearch
75.09
32%
-101
- C1 -
2YYZ
3
?
A:
[2-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
I
R
V
V
N
L
K
K
Y
F
-
G
----
K
-----
V
--
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
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A
L
L
G
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K
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T
T
L
L
M
L
A
G
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Y
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----
V
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L
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N
D
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Y
R
E
V
G
M
V
F
Q
N
--------
Y
A
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L
Y
P
H
M
T
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F
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N
I
A
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----
P
L
R
A
-----
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R
I
S
KD
E
V
E
K
R
-----
V
-----
V
--
E
I
----
A
R
K
L
--
L
I
D
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N
L
L
D
R
K
P
T
Q
L
S
G
G
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Q
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R
A
L
V
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K
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L
L
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D
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L
S
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L
D
A
N
L
----
R
M
I
M
R
A
E
I
K
H
L
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Q
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G
I
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S
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Y
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F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
74.67
32%
-118
- C1 -
1Z47
1
?
B:
[19-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
E
K
I
Y
P
G
----
G
-----
A
--
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
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R
P
T
K
G
D
V
W
I
G
G
--------
K
----
R
V
T
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---
L
P
--
P
Q
-----------------
K
R
N
V
G
L
V
F
Q
N
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Y
A
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L
F
Q
H
M
T
V
Y
D
N
V
S
F
----
G
L
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D
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Y
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P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
---------
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
----------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
74.45
30%
-113
- C1 -
4U00
3
?
A:
[3-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
I
R
I
R
N
L
H
K
W
F
-
G
----
P
-----
L
--
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
----
L
---
S
----
V
K
D
-
D
---
R
A
L
R
E
I
-----------------
R
R
E
V
G
M
V
F
Q
Q
--------
F
N
-
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
-----
P
R
E
K
-----
A
E
-----
K
-----
K
A
L
E
L
----
L
E
R
V
--
G
I
L
-
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
-------
M
V
G
E
V
L
D
V
M
-
R
D
L
A
Q
-
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
------------------------------------------------------------------------------------------------------
63
HHSearch
74.29
30%
-101
- C1 -
1Z47
1
?
A:
[11-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
-
P
G---
G
-----
A
--
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
----
K
---
R
----
V
T
D
-
L
---
P
---
P
Q
-----------------
K
R
N
V
G
L
V
F
Q
N
--------
Y
A
-
L
F
Q
H
M
T
V
Y
D
N
V
S
F
----
G
L
R
E
-----
K
R
V
P
K
D
E
M
D
A
R
-----
V
-----
R
--
E
L
----
L
R
F
M
--
R
L
E
-
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
----
R
R
E
L
R
T
F
V
R
Q
V
-
H
---
D
E
M
-
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
-----------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.26
29%
-109
- C1 -
4YMS
-
?
J:
[7-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
K
N
F
-
G
----
S
-----
L
--
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
----
V
KIN
N
----
G
K
V
-
N
---
I
N
--
K
V
-----------------
R
Q
K
V
G
M
V
F
Q
H
--------
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
AP--
V
K
V
K
-----
K
M
N
K
-----
K
E
-----
A
-----
E
--
E
L
AVDL
L
A
K
V
--
G
L
L
-
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
K
E
V
L
N
V
M
K
Q
L
-
A
---
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
74.09
32%
-120
- C1 -
1Z47
1
?
A:
[19-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
E
K
I
Y
P
G
----
G
-----
A
--
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
--------
K
----
R
V
T
-
D
---
L
P
--
P
Q
-----------------
K
R
N
V
G
L
V
F
Q
N
--------
Y
A
-
L
F
Q
H
M
T
V
Y
D
N
V
S
F
----
G
L
R
E
-----
K
R
V
P
-----
K
D
-----
E
M
D
A
R
V
R
--
E
L
----
L
R
F
M
--
R
L
E
-
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
---------
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
----------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.87
29%
-107
- C1 -
4YMU
2
?
J:
[7-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
K
N
F
-
G
----
S
-----
L
--
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
----
V
KIN
N
----
G
K
V
-
N
---
I
N
--
K
V
-----------------
R
Q
K
V
G
M
V
F
Q
H
--------
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
AP--
V
K
V
K
-----
K
M
N
K
-----
K
E
-----
A
-----
E
--
E
L
AVDL
L
A
K
V
--
G
L
L
-
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
K
E
V
L
N
V
M
K
Q
L
-
A
---
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.49
33%
-116
- C1 -
4WBS
1
?
A:
[37-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
S
L
V
V
R
N
L
K
K
R
Y
-
G
----
S
-----
R
--
T
V
V
K
D
V
S
L
D
V
K
S
G
E
V
V
G
L
L
G
P
N
G
A
G
K
T
T
S
F
Y
M
I
V
G
L
V
P
L
D
A
G
E
I
D
L
D
G
KSIS
L
---
L
----
P
I
H
-
K
---
R
A
--
S
L
G
L
S
Y
L
P
QEASVFRKLS
V
E
E
N
I
R
A
V
L
E
L
--------
Q
V
-
G
D
D
G
K
R
L
S
K
--
D
A
----
I
A
S
R
-----
T
---------------------
E
--
A
L
----
L
D
E
L
--
Q
I
S
-
H
L
R
E
N
P
A
L
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
T
N
P
S
F
I
L
L
D
E
P
F
A
G
V
D
P
I
A
----
V
L
E
I
Q
K
I
V
K
F
L
-
K
---
Q
-
R
-
N
I
G
V
L
I
T
D
H
N
V
R
E
T
L
G
I
C
D
H
A
Y
I
I
S
D
G
S
V
L
A
A
G
A
P
G
D
I
I
E
N
-------------------------------------------------------------------------------------------------------------
71
HHSearch
73.44
29%
-105
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
----
E
-----
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
----
K
---
R
----
M
N
D
-
T
---
P
---
P
A
-----------------
E
R
G
V
G
M
V
F
Q
S
--------
Y
A
-
L
Y
P
H
L
S
V
A
E
N
M
S
F
----
G
L
K
L
-----
A
G
A
K
K
E
V
I
N
Q
R
-----
V
-----
N
--
Q
V
----
A
E
V
L
--
Q
L
A
-
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
----
R
V
Q
M
R
I
E
I
S
R
L
-
H
---
K
R
L
-
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
-----------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
72.72
29%
-107
- C1 -
4YMW
-
?
J:
[7-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
K
N
F
-
G
----
S
-----
L
--
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
----
V
KIN
N
----
G
K
V
-
N
---
I
N
--
K
V
-----------------
R
Q
K
V
G
M
V
F
Q
H
--------
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
AP--
V
K
V
K
-----
K
M
N
K
-----
K
E
-----
A
-----
E
--
E
L
AVDL
L
A
K
V
--
G
L
L
-
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
K
E
V
L
N
V
M
K
Q
L
-
A
---
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.60
29%
-105
- C1 -
4YMV
1
?
J:
[7-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
K
N
F
-
G
----
S
-----
L
--
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
----
V
KIN
N
----
G
K
V
-
N
---
I
N
--
K
V
-----------------
R
Q
K
V
G
M
V
F
Q
H
--------
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
AP--
V
K
V
K
-----
K
M
N
K
-----
K
E
-----
A
-----
E
--
E
L
AVDL
L
A
K
V
--
G
L
L
-
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
K
E
V
L
N
V
M
K
Q
L
-
A
---
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.49
29%
-106
- C1 -
4YMT
-
?
J:
[7-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
K
N
F
-
G
----
S
-----
L
--
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
----
V
KIN
N
----
G
K
V
-
N
---
I
N
--
K
V
-----------------
R
Q
K
V
G
M
V
F
Q
H
--------
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
AP--
V
K
V
K
-----
K
M
N
K
-----
K
E
-----
A
-----
E
--
E
L
AVDL
L
A
K
V
--
G
L
L
-
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
----
V
K
E
V
L
N
V
M
K
Q
L
-
A
---
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
------------------------------------------------------------------------------------------------------
78
HHSearch
72.38
24%
-111
- C1 -
4MKI
4
ECFA2_CALS4
B:
[5-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
I
K
V
E
N
V
S
F
I
Y
-
N
----
E
GTPYA
T
--
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
----
I
---
D
----
I
T
D
-
K
KVS
L
K
--
D
I
-----------------
R
K
Q
V
G
L
V
F
Q
Y
--------
P
E
Y
Q
L
F
E
E
T
V
F
K
D
I
A
F
----
G
P
S
N
-----
L
G
L
S
E
E
E
V
K
E
R
-----
V
-----
Y
--
E
A
----
M
E
I
V
--
G
I
S
K
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
----
K
Q
E
I
L
N
K
I
K
E
I
-
H
---
D
K
Y
-
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
A
------------------------------------------------------------------------------------------------------------
61
Fugue
71.75
26%
-80
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
LKPLLDDGFGKTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
MPVAFFDKQS
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
FYYS
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
KEVLIFGG
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
SEQEK
D
E
G
K
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
----
G
-----
R
EV
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
----
H
---
D
----
L
R
E
Y
T
---
L
A
--
S
L
-----------------
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
NDT
V
A
N
-
N
I
A
Y
A
R
T
E
E
Y
S
R
E
----
Q
I
E
E
-----
A
A
R
M
-----
A
Y
-----
A
-----
M
--
D
F
----
I
N
K
M
DN
G
L
D
-
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
----
E
R
A
I
Q
A
A
L
D
E
L
-
Q
---
K
-
N
-
R
T
S
L
V
I
A
--
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
-----
Y
A
Q
--------
L
H
K
M
Q
F
G
-----------------------------------------------------------------------------------
62
HHSearch
54.48
32%
-17
- C1 -
4YER
4
?
A:
[3-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
I
V
V
E
N
L
V
K
K
F
-
G
----
D
-----
F
--
E
A
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
W
V
A
G
----
H
---
D
----
V
L
K
-
E
---
P
R
--
E
V
-----------------
R
R
K
I
G
I
V
F
Q
D
--------
Q
S
-
L
D
R
E
L
T
A
Y
E
N
M
Y
I
----
H
G
K
I
-----
Y
G
Y
G
G
E
K
L
K
K
R
-----
I
-----
L
--
E
L
----
L
E
F
V
--
E
L
L
-
E
F
K
D
K
P
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
----
R
A
H
M
W
E
Y
I
S
K
M
-
K
---
K
E
H
-
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
A
L
G
T
P
T
E
L
K
R
M
V
G
K
E
I
I
Y
-
V
R
--------------------
D
F
I
E
S
--
C
R
K
L
P
D
G
R
L
E
L
N
V
E
D
------------------------------
I
E
E
I
T
Y
H
K
P
T
L
N
D
V
F
L
H
L
T
G
R
E
L
----