@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1493: (2016-05-02 )
MTTKTPVIGSFAGVPLHSERAAQSPTEAAVHTHVAAAAAAHGYTPEQLVWHTPEGIDVTPVYIAADRAAAEAEGYPLHSFPGEPPFVRGPYPTMYVNQPWTIRQYAGFSTAADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFDGIDLSTVSVSMTMNGAVLPILALYVVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIRAGLNAGLDIDSFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAQFAPKSAKSLSLRTHSQTSGWSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLVLQQESGTTRPIDPWGGSYYVEWLTHRLARRARAHIAEVAEHGGMAQAISDGIPKLRIEEAAARTQARIDSGQQPVVGVNKYQVPEDHEIEVLKVENSRVRAEQLAKLQRLRAGRDEPAVRAALAELTRAAAEQGRAGADGLGNNLLALAIDAARAQATVGEISEALEKVYGRHRAEIRTISGVYRDEVGKAPNIAAATELVEKFAEADGRRPRILIAKMGQDGHDRGQKVIATAFADIGFDVDVGSLFSTPEEVARQAADNDVHVIGVSSLAAGHLTLVPALRDALAQVGRPDIMIVVGGVIPPGDFDELYAAGATAIFPPGTVIADAAIDLLHRLAERLGYTLD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330........340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580..---...-..590-.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730----.......740.......750
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTTKTPVIGSFAGVPLH
S
E
RAAQSP
T
E
A
A
V
H
T
H
V
A
A
A
A
AAHGY
T
P
E
Q
L
V
WHTPEG
I
D
V
T
P
V
Y
I
AADRAAAEAEGYPLHSFPGEPPFVRGPYP
T
M
Y
VNQP
W
T
I
R
QYAGFSTAADSN
A
F
Y
R
R
N
LAAGQKG
L
S
V
A
F
D
LATHRGYDSDHPRVQGDVGM
A
G
V
A
I
D
S
I
L
D
M
R
Q
L
FDGID
L
S
T
V
S
V
S
M
TMNG
A
V
L
P
I
L
A
L
Y
V
VAAEEQGV
A
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
VRN
T
Y
IYPPKP
S
M
R
I
I
S
D
I
F
A
Y
TSAKMPKF
N
S
I
S
I
S
G
Y
H
I
QEAGATA
D
L
E
L
A
Y
TLAD
G
V
D
Y
I
R
A
G
L
NAGLDIDSFA
P
R
L
S
F
F
W
GI
G
M
N
F
F
M
E
V
A
K
LRA
G
R
L
L
W
S
E
L
V
A
Q
-FAPKSAK
S
L
S
L
R
THSQTSG
W
S
L
T
A
Q
D
V
F
N
N
V
A
R
T
C
I
E
A
M
A
ATQGHTQSL
H
T
N
A
L
D
E
A
LALPTD
F
S
A
R
IARN
T
Q
L
V
L
QQESGTTRPIDPWG
G
S
Y
Y
V
E
W
L
T
H
R
L
A
R
R
A
R
A
H
I
A
E
V
A
E
HGG
M
A
Q
A
I
SDGIP
K
L
R
I
E
E
A
A
A
R
T
Q
A
RIDSGQQPVVGVNKYQVPEDH
E
I
E
V
L
K
VENSR
V
R
A
E
Q
L
A
K
L
Q
R
L
RAGRD
E
P
A
V
R
A
A
L
A
E
L
T
R
A
A
A
EQGRAGADGLGNN
L
L
A
L
A
IDAARAQ
A
T
V
G
E
I
S
E
A
L
E
K
V
Y
G
R
H
R
A
E
I
R
T
---
I
S
G
-
V
Y
R
D
E-VGKAP
N
I
A
A
A
T
E
L
V
E
K
F
A
E
ADGRR
P
R
I
L
I
A
KMGQDGHDR
G
Q
K
V
I
A
T
A
F
A
DIGFDV
D
V
G
S
LFS
T
P
E
E
V
A
R
Q
AADN
D
V
H
V
I
G
V
S
SLAAG
H
L
T
L
V
P
A
L
R
D
A
L
A
QVGRP
D
I
M
I
V
VGGVIPPG
D
F
D
E
L
Y
AAGATAIFPP
G
T
V
I
A
D
----
A
A
I
D
L
L
H
R
L
A
E
RLGYTLD
53
HHSearch
96.46
71%
-81
- C3 -
1REQ
4
MUTB_PROFR
A:
[14-725]
---------------------
A
P
V
P
A
D
A
A
R
R
F
E
E
L
A
A
K
A
G
T
G
-----
E
A
W
E
T
A
E
Q
I
P
V
G
T
L
F
N
E
D
V
Y
K
D
M
D
----
W
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
---
D
D
K
D
P
D
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
I
S
G
V
Y
S
K
E
V
K
N
T
-----
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
R
A
S
L
-----
21
PsiBlast_CBE
95.58
75%
-82
- C3 -
7REQ
2
MUTB_PROFR
C:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
1
PsiBlast_PDB
95.48
75%
-82
- C3 -
1REQ
4
MUTB_PROFR
A:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
5
PsiBlast_PDB
95.43
75%
-82
- C3 -
7REQ
2
MUTB_PROFR
A:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
4
PsiBlast_PDB
95.36
75%
-82
- C3 -
6REQ
3
MUTB_PROFR
A:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
8
PsiBlast_PDB
95.09
75%
-79
- C3 -
1E1C
2
MUTB_PROFR
A:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
A
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
27
PsiBlast_CBE
95.08
75%
-81
- C3 -
1E1C
2
MUTB_PROFR
C:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
A
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
7
PsiBlast_PDB
95.07
75%
-81
- C3 -
5REQ
2
MUTB_PROFR
A:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
F
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
25
PsiBlast_CBE
94.88
75%
-81
- C3 -
1REQ
4
MUTB_PROFR
C:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
22
PsiBlast_CBE
94.84
75%
-82
- C3 -
6REQ
3
MUTB_PROFR
C:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
26
PsiBlast_CBE
94.78
75%
-81
- C3 -
5REQ
2
MUTB_PROFR
C:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
F
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
2
PsiBlast_PDB
94.78
75%
-86
- C3 -
2REQ
2
MUTB_PROFR
A:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
6
PsiBlast_PDB
94.76
75%
-82
- C3 -
4REQ
4
MUTB_PROFR
A:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
23
PsiBlast_CBE
94.49
75%
-81
- C3 -
4REQ
4
MUTB_PROFR
C:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
24
PsiBlast_CBE
94.46
75%
-85
- C3 -
2REQ
2
MUTB_PROFR
C:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
3
PsiBlast_PDB
92.58
75%
-82
- C3 -
3REQ
2
MUTB_PROFR
A:
[60-721]
----------------------------------------------------------------------------
L
D
T
Y
A
G
I
P
P
F
V
H
G
P
Y
A
T
M
Y
A
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
A
K
E
S
N
A
F
Y
R
R
N
L
A
A
G
Q
K
G
L
S
V
A
F
D
L
P
T
H
R
G
Y
D
S
D
N
P
R
V
A
G
D
V
G
M
A
G
V
A
I
D
S
I
Y
D
M
R
E
L
F
A
G
I
P
L
D
Q
M
S
V
S
M
T
M
N
G
A
V
L
P
I
L
A
L
Y
V
V
T
A
E
E
Q
G
V
K
P
E
Q
L
A
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
Y
P
P
Q
P
S
M
R
I
I
S
E
I
F
A
Y
T
S
A
N
M
P
K
W
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
T
A
D
I
E
M
A
Y
T
L
A
D
G
V
D
Y
I
R
A
G
E
S
V
G
L
N
V
D
Q
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
F
M
E
V
A
K
L
R
A
A
R
M
L
W
A
K
L
V
H
Q
-
F
G
P
K
N
P
K
S
M
S
L
R
T
H
S
Q
T
S
G
W
S
L
T
A
Q
D
V
Y
N
N
V
V
R
T
C
I
E
A
M
A
A
T
Q
G
H
T
Q
S
L
H
T
N
S
L
D
E
A
I
A
L
P
T
D
F
S
A
R
I
A
R
N
T
Q
L
F
L
Q
Q
E
S
G
T
T
R
V
I
D
P
W
S
G
S
A
Y
V
E
E
L
T
W
D
L
A
R
K
A
W
G
H
I
Q
E
V
E
K
V
G
G
M
A
K
A
I
E
K
G
I
P
K
M
R
I
E
E
A
A
A
R
T
Q
A
R
I
D
S
G
R
Q
P
L
I
G
V
N
K
Y
R
L
E
H
E
P
P
L
D
V
L
K
V
D
N
S
T
V
L
A
E
Q
K
A
K
L
V
K
L
R
A
E
R
D
P
E
K
V
K
A
A
L
D
K
I
T
W
A
A
G
N
P
D
D
K
D
P
D
---
R
N
L
L
K
L
C
I
D
A
G
R
A
M
A
T
V
G
E
M
S
D
A
L
E
K
V
F
G
R
Y
T
A
Q
I
R
T
---
I
S
G
-
V
Y
S
K
E
-
V
K
N
T
P
E
V
E
E
A
R
E
L
V
E
E
F
E
Q
A
E
G
R
R
P
R
I
L
L
A
K
M
G
Q
D
G
H
D
R
G
Q
K
V
I
A
T
A
Y
A
D
L
G
F
D
V
D
V
G
P
L
F
Q
T
P
E
E
T
A
R
Q
A
V
E
A
D
V
H
V
V
G
V
S
S
L
A
G
G
H
L
T
L
V
P
A
L
R
K
E
L
D
K
L
G
R
P
D
I
L
I
T
V
G
G
V
I
P
E
Q
D
F
D
E
L
R
K
D
G
A
V
E
I
Y
T
P
G
T
V
I
P
E
----
S
A
I
S
L
V
K
K
L
---------
29
PsiBlast_CBE
91.22
60%
-77
- C3 -
2XIQ
3
MUTA_HUMAN
B:
[28-733]
--------------
P
L
H
P
E
W
A
A
------------
L
A
K
K
Q
L
K
G
K
N
P
E
D
L
I
W
H
T
P
E
G
I
S
I
K
P
L
Y
S
K
R
D
T
M
D
L
P
E
E
------
L
P
G
V
K
P
F
T
R
G
P
Y
P
T
M
Y
T
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
V
E
E
S
N
K
F
Y
K
D
N
I
K
A
G
Q
Q
G
L
S
V
A
F
D
L
A
T
H
R
G
Y
D
S
D
N
P
R
V
R
G
D
V
G
M
A
G
V
A
I
D
T
V
E
D
T
K
I
L
F
D
G
I
P
L
E
K
M
S
V
S
M
T
M
N
G
A
V
I
P
V
L
A
N
F
I
V
T
G
E
E
Q
G
V
P
K
E
K
L
T
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
F
P
P
E
P
S
M
K
I
I
A
D
I
F
E
Y
T
A
K
H
M
P
K
F
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
D
A
I
L
E
L
A
Y
T
L
A
D
G
L
E
Y
S
R
T
G
L
Q
A
G
L
T
I
D
E
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
Y
M
E
I
A
K
M
R
A
G
R
R
L
W
A
H
L
I
E
K
M
F
Q
P
K
N
S
K
S
L
L
L
R
A
H
C
Q
T
S
G
W
S
L
T
E
Q
D
P
Y
N
N
I
V
R
T
A
I
E
A
M
A
A
V
F
G
G
T
Q
S
L
H
T
N
S
F
D
E
A
L
G
L
P
T
V
K
S
A
R
I
A
R
N
T
Q
I
I
I
Q
E
E
S
G
I
P
K
V
A
D
P
W
G
G
S
Y
M
M
E
C
L
T
N
D
V
Y
D
A
A
L
K
L
I
N
E
I
E
E
M
G
G
M
A
K
A
V
A
E
G
I
P
K
L
R
I
E
E
C
A
A
R
R
Q
A
R
I
D
S
G
S
E
V
I
V
G
V
N
K
Y
Q
L
E
K
E
D
T
V
E
V
L
A
I
D
N
T
S
V
R
N
R
Q
I
E
K
L
K
K
I
K
S
S
R
D
Q
-----
A
L
A
E
R
C
L
A
A
L
T
E
C
A
A
S
G
D
G
---
N
I
L
A
L
A
V
D
A
S
R
A
R
C
T
V
G
E
I
T
D
A
L
K
K
V
F
G
E
H
K
A
N
D
R
M
---
V
S
G
-
A
Y
R
Q
E
-
F
G
E
S
K
E
I
T
S
A
I
K
R
V
H
K
F
M
E
R
E
G
R
R
P
R
L
L
V
A
K
M
G
Q
D
G
H
D
R
G
A
K
V
I
A
T
G
F
A
D
L
G
F
D
V
D
I
G
P
L
F
Q
T
P
R
E
V
A
Q
Q
A
V
D
A
D
V
H
A
V
G
V
S
T
L
A
A
G
H
K
T
L
V
P
E
L
I
K
E
L
N
S
L
G
R
P
D
I
L
V
M
C
G
G
V
I
P
P
Q
D
Y
E
F
L
F
E
V
G
V
S
N
V
F
G
P
G
T
R
I
P
K
----
A
A
V
Q
V
L
D
D
I
E
K
C
L
-----
11
PsiBlast_PDB
91.08
60%
-77
- C3 -
2XIQ
3
MUTA_HUMAN
A:
[28-733]
--------------
P
L
H
P
E
W
A
A
------------
L
A
K
K
Q
L
K
G
K
N
P
E
D
L
I
W
H
T
P
E
G
I
S
I
K
P
L
Y
S
K
R
D
T
M
D
L
P
E
E
------
L
P
G
V
K
P
F
T
R
G
P
Y
P
T
M
Y
T
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
V
E
E
S
N
K
F
Y
K
D
N
I
K
A
G
Q
Q
G
L
S
V
A
F
D
L
A
T
H
R
G
Y
D
S
D
N
P
R
V
R
G
D
V
G
M
A
G
V
A
I
D
T
V
E
D
T
K
I
L
F
D
G
I
P
L
E
K
M
S
V
S
M
T
M
N
G
A
V
I
P
V
L
A
N
F
I
V
T
G
E
E
Q
G
V
P
K
E
K
L
T
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
F
P
P
E
P
S
M
K
I
I
A
D
I
F
E
Y
T
A
K
H
M
P
K
F
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
D
A
I
L
E
L
A
Y
T
L
A
D
G
L
E
Y
S
R
T
G
L
Q
A
G
L
T
I
D
E
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
Y
M
E
I
A
K
M
R
A
G
R
R
L
W
A
H
L
I
E
K
M
F
Q
P
K
N
S
K
S
L
L
L
R
A
H
C
Q
T
S
G
W
S
L
T
E
Q
D
P
Y
N
N
I
V
R
T
A
I
E
A
M
A
A
V
F
G
G
T
Q
S
L
H
T
N
S
F
D
E
A
L
G
L
P
T
V
K
S
A
R
I
A
R
N
T
Q
I
I
I
Q
E
E
S
G
I
P
K
V
A
D
P
W
G
G
S
Y
M
M
E
C
L
T
N
D
V
Y
D
A
A
L
K
L
I
N
E
I
E
E
M
G
G
M
A
K
A
V
A
E
G
I
P
K
L
R
I
E
E
C
A
A
R
R
Q
A
R
I
D
S
G
S
E
V
I
V
G
V
N
K
Y
Q
L
E
K
E
D
T
V
E
V
L
A
I
D
N
T
S
V
R
N
R
Q
I
E
K
L
K
K
I
K
S
S
R
D
Q
-----
A
L
A
E
R
C
L
A
A
L
T
E
C
A
A
S
G
D
G
---
N
I
L
A
L
A
V
D
A
S
R
A
R
C
T
V
G
E
I
T
D
A
L
K
K
V
F
G
E
H
K
A
N
D
R
M
---
V
S
G
-
A
Y
R
Q
E
-
F
G
E
S
K
E
I
T
S
A
I
K
R
V
H
K
F
M
E
R
E
G
R
R
P
R
L
L
V
A
K
M
G
Q
D
G
H
D
R
G
A
K
V
I
A
T
G
F
A
D
L
G
F
D
V
D
I
G
P
L
F
Q
T
P
R
E
V
A
Q
Q
A
V
D
A
D
V
H
A
V
G
V
S
T
L
A
A
G
H
K
T
L
V
P
E
L
I
K
E
L
N
S
L
G
R
P
D
I
L
V
M
C
G
G
V
I
P
P
Q
D
Y
E
F
L
F
E
V
G
V
S
N
V
F
G
P
G
T
R
I
P
K
----
A
A
V
Q
V
L
D
D
I
E
K
C
L
-----
10
PsiBlast_PDB
90.88
60%
-79
- C3 -
2XIJ
13
MUTA_HUMAN
A:
[28-733]
--------------
P
L
H
P
E
W
A
A
------------
L
A
K
K
Q
L
K
G
K
N
P
E
D
L
I
W
H
T
P
E
G
I
S
I
K
P
L
Y
S
K
R
D
T
M
D
L
P
E
E
------
L
P
G
V
K
P
F
T
R
G
P
Y
P
T
M
Y
T
F
R
P
W
T
I
R
Q
Y
A
G
F
S
T
V
E
E
S
N
K
F
Y
K
D
N
I
K
A
G
Q
Q
G
L
S
V
A
F
D
L
A
T
H
R
G
Y
D
S
D
N
P
R
V
R
G
D
V
G
M
A
G
V
A
I
D
T
V
E
D
T
K
I
L
F
D
G
I
P
L
E
K
M
S
V
S
M
T
M
N
G
A
V
I
P
V
L
A
N
F
I
V
T
G
E
E
Q
G
V
P
K
E
K
L
T
G
T
I
Q
N
D
I
L
K
E
F
M
V
R
N
T
Y
I
F
P
P
E
P
S
M
K
I
I
A
D
I
F
E
Y
T
A
K
H
M
P
K
F
N
S
I
S
I
S
G
Y
H
M
Q
E
A
G
A
D
A
I
L
E
L
A
Y
T
L
A
D
G
L
E
Y
S
R
T
G
L
Q
A
G
L
T
I
D
E
F
A
P
R
L
S
F
F
W
G
I
G
M
N
F
Y
M
E
I
A
K
M
R
A
G
R
R
L
W
A
H
L
I
E
K
M
F
Q
P
K
N
S
K
S
L
L
L
R
A
H
C
Q
T
S
G
W
S
L
T
E
Q
D
P
Y
N
N
I
V
R
T
A
I
E
A
M
A
A
V
F
G
G
T
Q
S
L
H
T
N
S
F
D
E
A
L
G
L
P
T
V
K
S
A
R
I
A
R
N
T
Q
I
I
I
Q
E
E
S
G
I
P
K
V
A
D
P
W
G
G
S
Y
M
M
E
C
L
T
N
D
V
Y
D
A
A
L
K
L
I
N
E
I
E
E
M
G
G
M
A
K
A
V
A
E
G
I
P
K
L
R
I
E
E
C
A
A
R
R
Q
A
R
I
D
S
G
S
E
V
I
V
G
V
N
K
Y
Q
L
E
K
E
D
T
V
E
V
L
A
I
D
N
T
S
V
R
N
R
Q
I
E
K
L
K
K
I
K
S
S
R
D
Q
-----
A
L
A
E
R
C
L
A
A
L
T
E
C
A
A
S
G
D
G
---
N
I
L
A
L
A
V
D
A
S
R
A
R
C
T
V
G
E
I
T
D
A
L
K
K
V
F
G
E
H
K
A
N
D
R
M
---
V
S
G
-
A
Y
R
Q
E
-
F
G
E
S
K
E
I
T
S
A
I
K
R
V
H
K
F
M
E
R
E
G
R
R
P
R
L
L
V
A
K
M
G
Q
D
G
H
D
R
G
A
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A
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A
D
L
G
F
D
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D
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A
Q
Q
A
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D
A
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A
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V
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T
L
A
A
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T
L
V
P
E
L
I
K
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L
N
S
L
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P
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L
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M
C
G
G
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Y
E
F
L
F
E
V
G
V
S
N
V
F
G
P
G
T
R
I
P
K
----
A
A
V
Q
V
L
D
D
I
E
K
C
L
-----
52
HHSearch
90.58
60%
-79
- C3 -
2XIJ
13
MUTA_HUMAN
A:
[26-735]
------------------------
Q
Q
P
L
H
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W
A
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K
K
Q
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D
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------
E
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A
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A
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A
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C
A
A
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--------
G
D
G
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I
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A
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A
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A
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A
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---
V
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--
A
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A
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A
A
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L
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L
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S
L
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L
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G
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A
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C
L
E
K
-------