@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1544: (2016-05-02 )
MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRERLDELADQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAGLCNSAGFGTSGRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGAVLNIASIAGFQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEIASAERFSIPLAQVSPHDVAEAAIAGMLSGKRTVVPGIVPKFVSTSGRFAPRSLLLPAIRIGNRLRGGPSR
Atome Classification :
(52 SA)
.........10........20.----.......30........40...-......50......-..60..--......70-.-.......80-----...--....----.---90......-..100.......110..-.....120.......--130.......140.......150.......160.......170.......180.......190.-.----.-----------....200----------------...-----...-..-210-.........220.......230.......240.......250.......260.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSLPKPNN
Q
T
T
V
V
I
TGASSG
I
G
----
V
E
L
A
R
G
LAGRGF
P
L
M
L
V
A
-
R
R
R
-
E
R
L
D
E
L
A
D
Q
L
R
Q
EH-CVG
V
E
V
--
L
PLDLA
D
T
-
Q
-
A
R
A
Q
L
A
D
R
L
-----
R
S
D
--
A
I
A
G
----
L
---CNSAGFGT-SG
R
F
WELPFAR
E
S
E
E
V
V
-
L
N
A
L
A
L
M
E
L
T
H
A
A
L
P
--
G
M
V
K
RGA
G
A
V
L
N
I
A
S
IAGFQPI
P
Y
M
A
V
Y
S
A
T
K
A
F
V
L
T
F
S
E
A
V
Q
E
E
LHGTG
V
S
V
T
A
LCPGPV
P
T
E
-
W
----
A
-----------
E
I
ASAE-----------------RFS-----IPL-AQ-V---
S
P
H
D
V
A
E
A
A
I
A
G
M
LSGKRTVVP
G
I
V
P
K
F
VSTSGRFA
P
R
S
L
L
L
P
A
I
R
IGNRLRGGPSR
28
PsiBlast_CBE
82.88
45%
-116
- C1 -
4BMV
1
?
C:
[6-191]
----------
T
V
L
I
T
G
A
S
S
G
I
G
----
A
T
Y
A
E
R
F
A
R
R
G
H
D
L
V
L
V
A
-
R
D
K
-
V
R
L
D
A
L
A
A
R
L
R
D
E
S
-
G
V
A
V
E
A
--
L
Q
A
D
L
T
R
P
-
A
-
D
L
A
A
V
E
I
R
L
-----
R
E
D
--
A
R
I
G
I---
L
---
I
N
N
A
G
M
A
Q
-
S
G
G
F
V
Q
Q
T
A
E
G
I
E
R
L
I
T
-
L
N
T
T
A
L
T
R
L
A
A
A
V
A
P
--
R
F
V
Q
S
G
T
G
A
I
V
N
I
G
S
V
V
G
F
A
P
E
F
G
M
S
I
Y
G
A
T
K
A
F
V
L
F
L
S
Q
G
L
N
L
E
L
S
P
S
G
I
Y
V
Q
A
V
L
P
A
A
T
R
T
E
I
W
-------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
82.36
45%
-115
- C1 -
4BMV
1
?
D:
[6-191]
----------
T
V
L
I
T
G
A
S
S
G
I
G
----
A
T
Y
A
E
R
F
A
R
R
G
H
D
L
V
L
V
A
-
R
D
K
-
V
R
L
D
A
L
A
A
R
L
R
D
E
S
-
G
V
A
V
E
A
--
L
Q
A
D
L
T
R
P
-
A
-
D
L
A
A
V
E
I
R
L
-----
R
E
D
--
A
R
I
G
I---
L
---
I
N
N
A
G
M
A
Q
-
S
G
G
F
V
Q
Q
T
A
E
G
I
E
R
L
I
T
-
L
N
T
T
A
L
T
R
L
A
A
A
V
A
P
--
R
F
V
Q
S
G
T
G
A
I
V
N
I
G
S
V
V
G
F
A
P
E
F
G
M
S
I
Y
G
A
T
K
A
F
V
L
F
L
S
Q
G
L
N
L
E
L
S
P
S
G
I
Y
V
Q
A
V
L
P
A
A
T
R
T
E
I
W
-------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
82.13
45%
-114
- C1 -
4BMV
1
?
H:
[6-191]
----------
T
V
L
I
T
G
A
S
S
G
I
G
----
A
T
Y
A
E
R
F
A
R
R
G
H
D
L
V
L
V
A
-
R
D
K
-
V
R
L
D
A
L
A
A
R
L
R
D
E
S
-
G
V
A
V
E
A
--
L
Q
A
D
L
T
R
P
-
A
-
D
L
A
A
V
E
I
R
L
-----
R
E
D
--
A
R
I
G
I---
L
---
I
N
N
A
G
M
A
Q
-
S
G
G
F
V
Q
Q
T
A
E
G
I
E
R
L
I
T
-
L
N
T
T
A
L
T
R
L
A
A
A
V
A
P
--
R
F
V
Q
S
G
T
G
A
I
V
N
I
G
S
V
V
G
F
A
P
E
F
G
M
S
I
Y
G
A
T
K
A
F
V
L
F
L
S
Q
G
L
N
L
E
L
S
P
S
G
I
Y
V
Q
A
V
L
P
A
A
T
R
T
E
I
W
-------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
82.12
45%
-114
- C1 -
4BMV
1
?
F:
[6-191]
----------
T
V
L
I
T
G
A
S
S
G
I
G
----
A
T
Y
A
E
R
F
A
R
R
G
H
D
L
V
L
V
A
-
R
D
K
-
V
R
L
D
A
L
A
A
R
L
R
D
E
S
-
G
V
A
V
E
A
--
L
Q
A
D
L
T
R
P
-
A
-
D
L
A
A
V
E
I
R
L
-----
R
E
D
--
A
R
I
G
I---
L
---
I
N
N
A
G
M
A
Q
-
S
G
G
F
V
Q
Q
T
A
E
G
I
E
R
L
I
T
-
L
N
T
T
A
L
T
R
L
A
A
A
V
A
P
--
R
F
V
Q
S
G
T
G
A
I
V
N
I
G
S
V
V
G
F
A
P
E
F
G
M
S
I
Y
G
A
T
K
A
F
V
L
F
L
S
Q
G
L
N
L
E
L
S
P
S
G
I
Y
V
Q
A
V
L
P
A
A
T
R
T
E
I
W
-------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
81.78
45%
-114
- C1 -
4BMV
1
?
G:
[6-191]
----------
T
V
L
I
T
G
A
S
S
G
I
G
----
A
T
Y
A
E
R
F
A
R
R
G
H
D
L
V
L
V
A
-
R
D
K
-
V
R
L
D
A
L
A
A
R
L
R
D
E
S
-
G
V
A
V
E
A
--
L
Q
A
D
L
T
R
P
-
A
-
D
L
A
A
V
E
I
R
L
-----
R
E
D
--
A
R
I
G
I---
L
---
I
N
N
A
G
M
A
Q
-
S
G
G
F
V
Q
Q
T
A
E
G
I
E
R
L
I
T
-
L
N
T
T
A
L
T
R
L
A
A
A
V
A
P
--
R
F
V
Q
S
G
T
G
A
I
V
N
I
G
S
V
V
G
F
A
P
E
F
G
M
S
I
Y
G
A
T
K
A
F
V
L
F
L
S
Q
G
L
N
L
E
L
S
P
S
G
I
Y
V
Q
A
V
L
P
A
A
T
R
T
E
I
W
-------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
81.62
45%
-115
- C1 -
4BMV
1
?
E:
[6-191]
----------
T
V
L
I
T
G
A
S
S
G
I
G
----
A
T
Y
A
E
R
F
A
R
R
G
H
D
L
V
L
V
A
-
R
D
K
-
V
R
L
D
A
L
A
A
R
L
R
D
E
S
-
G
V
A
V
E
A
--
L
Q
A
D
L
T
R
P
-
A
-
D
L
A
A
V
E
I
R
L
-----
R
E
D
--
A
R
I
G
I---
L
---
I
N
N
A
G
M
A
Q
-
S
G
G
F
V
Q
Q
T
A
E
G
I
E
R
L
I
T
-
L
N
T
T
A
L
T
R
L
A
A
A
V
A
P
--
R
F
V
Q
S
G
T
G
A
I
V
N
I
G
S
V
V
G
F
A
P
E
F
G
M
S
I
Y
G
A
T
K
A
F
V
L
F
L
S
Q
G
L
N
L
E
L
S
P
S
G
I
Y
V
Q
A
V
L
P
A
A
T
R
T
E
I
W
-------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
81.38
45%
-115
- C1 -
4BMV
1
?
B:
[6-191]
----------
T
V
L
I
T
G
A
S
S
G
I
G
----
A
T
Y
A
E
R
F
A
R
R
G
H
D
L
V
L
V
A
-
R
D
K
-
V
R
L
D
A
L
A
A
R
L
R
D
E
S
-
G
V
A
V
E
A
--
L
Q
A
D
L
T
R
P
-
A
-
D
L
A
A
V
E
I
R
L
-----
R
E
D
--
A
R
I
G
I---
L
---
I
N
N
A
G
M
A
Q
-
S
G
G
F
V
Q
Q
T
A
E
G
I
E
R
L
I
T
-
L
N
T
T
A
L
T
R
L
A
A
A
V
A
P
--
R
F
V
Q
S
G
T
G
A
I
V
N
I
G
S
V
V
G
F
A
P
E
F
G
M
S
I
Y
G
A
T
K
A
F
V
L
F
L
S
Q
G
L
N
L
E
L
S
P
S
G
I
Y
V
Q
A
V
L
P
A
A
T
R
T
E
I
W
-------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.25
45%
-114
- C1 -
4BMV
1
?
A:
[6-191]
----------
T
V
L
I
T
G
A
S
S
G
I
G
----
A
T
Y
A
E
R
F
A
R
R
G
H
D
L
V
L
V
A
-
R
D
K
-
V
R
L
D
A
L
A
A
R
L
R
D
E
S
-
G
V
A
V
E
A
--
L
Q
A
D
L
T
R
P
-
A
-
D
L
A
A
V
E
I
R
L
-----
R
E
D
--
A
R
I
G
I---
L
---
I
N
N
A
G
M
A
Q
-
S
G
G
F
V
Q
Q
T
A
E
G
I
E
R
L
I
T
-
L
N
T
T
A
L
T
R
L
A
A
A
V
A
P
--
R
F
V
Q
S
G
T
G
A
I
V
N
I
G
S
V
V
G
F
A
P
E
F
G
M
S
I
Y
G
A
T
K
A
F
V
L
F
L
S
Q
G
L
N
L
E
L
S
P
S
G
I
Y
V
Q
A
V
L
P
A
A
T
R
T
E
I
W
-------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
80.73
45%
-115
- C1 -
4BMV
1
?
J:
[6-192]
----------
T
V
L
I
T
G
A
S
S
G
I
G
----
A
T
Y
A
E
R
F
A
R
R
G
H
D
L
V
L
V
A
-
R
D
K
-
V
R
L
D
A
L
A
A
R
L
R
D
E
S
-
G
V
A
V
E
A
--
L
Q
A
D
L
T
R
P
-
A
-
D
L
A
A
V
E
I
R
L
-----
R
E
D
--
A
R
I
G
I---
L
---
I
N
N
A
G
M
A
Q
-
S
G
G
F
V
Q
Q
T
A
E
G
I
E
R
L
I
T
-
L
N
T
T
A
L
T
R
L
A
A
A
V
A
P
--
R
F
V
Q
S
G
T
G
A
I
V
N
I
G
S
V
V
G
F
A
P
E
F
G
M
S
I
Y
G
A
T
K
A
F
V
L
F
L
S
Q
G
L
N
L
E
L
S
P
S
G
I
Y
V
Q
A
V
L
P
A
A
T
R
T
E
I
W
-------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
79.94
45%
-114
- C1 -
4BMV
1
?
I:
[6-192]
----------
T
V
L
I
T
G
A
S
S
G
I
G
----
A
T
Y
A
E
R
F
A
R
R
G
H
D
L
V
L
V
A
-
R
D
K
-
V
R
L
D
A
L
A
A
R
L
R
D
E
S
-
G
V
A
V
E
A
--
L
Q
A
D
L
T
R
P
-
A
-
D
L
A
A
V
E
I
R
L
-----
R
E
D
--
A
R
I
G
I---
L
---
I
N
N
A
G
M
A
Q
-
S
G
G
F
V
Q
Q
T
A
E
G
I
E
R
L
I
T
-
L
N
T
T
A
L
T
R
L
A
A
A
V
A
P
--
R
F
V
Q
S
G
T
G
A
I
V
N
I
G
S
V
V
G
F
A
P
E
F
G
M
S
I
Y
G
A
T
K
A
F
V
L
F
L
S
Q
G
L
N
L
E
L
S
P
S
G
I
Y
V
Q
A
V
L
P
A
A
T
R
T
E
I
W
-------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
79.31
32%
-109
- C1 -
3RI3
3
ACT3_STRCO
A:
[26-254]
--------
S
E
V
A
L
V
T
G
A
T
S
G
I
G
----
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
-
R
G
E
-
E
G
L
R
T
T
L
K
E
L
R
E
----
A
G
V
E
A
D
G
R
T
C
D
V
R
S
V
P
E
-
I
E
A
L
V
A
A
V
V
E
----
R
Y
G
--
P
V
D
V
----
L
---
V
N
N
A
G
R
L
G
-
G
G
A
T
A
E
L
A
D
E
L
W
L
D
V
V
E
-
T
N
L
T
G
V
F
R
V
T
K
Q
V
L
K
AG
G
M
L
E
R
G
T
G
R
I
V
N
I
A
S
T
G
G
K
Q
G
V
V
H
A
A
P
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
V
C
P
G
F
V
E
T
P
-
M
----
A
A
S
V
R
E
H
Y
S
D
I
W
E
V
S
T
E
E
-----------------
A
F
D
R
I
T
A
R
V
P
I
-
G
R
Y
V
---
Q
P
S
E
V
A
E
--------------------------------------------------
69
PsiBlast_CBE
79.27
31%
-105
- C1 -
4DBZ
1
ACT3_STRCO
B:
[24-254]
------
Q
D
S
E
V
A
L
V
T
G
A
T
S
G
I
G
----
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
-
R
G
E
-
E
G
L
R
T
T
L
K
E
L
R
E
----
A
G
V
E
A
---
D
G
R
T
C
D
V
-
R
-
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
--
P
V
D
V
----
L
---
V
N
N
A
G
R
P
G
-
G
G
A
T
A
E
L
A
D
E
L
W
L
D
V
V
E
-
T
N
L
T
G
V
F
R
V
T
K
Q
V
L
K
A
G
G
M
L
E
R
G
T
G
R
I
V
N
I
A
S
T
G
G
K
Q
G
L
V
H
A
A
P
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
V
C
P
G
F
V
E
T
P
-
M
----
A
A
S
V
R
E
H
Y
S
D
I
W
E
V
S
T
E
E
-----------------
A
F
D
R
I
T
A
R
V
P
I
-
G
R
Y
V
---
Q
P
S
E
V
A
E
--------------------------------------------------
55
PsiBlast_CBE
78.73
31%
-104
- C1 -
4DC1
1
ACT3_STRCO
B:
[24-254]
------
Q
D
S
E
V
A
L
V
T
G
A
T
S
G
I
G
----
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
-
R
G
E
-
E
G
L
R
T
T
L
K
E
L
R
E
----
A
G
V
E
A
---
D
G
R
T
C
D
V
-
R
-
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
--
P
V
D
V
----
L
---
V
N
N
A
G
R
P
G
-
G
G
A
T
A
E
L
A
D
E
L
W
L
D
V
V
E
-
T
N
L
T
G
V
F
R
V
T
K
Q
V
L
K
AG
G
M
L
E
R
G
T
G
R
I
V
N
I
A
S
T
G
G
K
Q
G
V
V
H
A
A
P
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
V
C
P
G
F
V
E
T
P
-
M
----
A
A
S
V
R
E
H
F
S
D
I
W
E
V
S
T
E
E
-----------------
A
F
D
R
I
T
A
R
V
P
I
-
G
R
Y
V
---
Q
P
S
E
V
A
E
--------------------------------------------------
60
PsiBlast_CBE
78.32
32%
-104
- C1 -
3QRW
1
ACT3_STRCO
B:
[24-254]
------
Q
D
S
E
V
A
L
V
T
G
A
T
S
G
I
G
----
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
-
R
G
E
-
E
G
L
R
T
T
L
K
E
L
R
E
----
A
G
V
E
A
D
G
R
T
C
D
V
R
S
V
P
E
-
I
E
A
L
V
A
A
V
V
E
----
R
Y
G
--
P
V
D
V
----
L
---
V
N
N
A
G
R
L
G
-
G
G
A
T
A
E
L
A
D
E
L
W
L
D
V
V
E
-
T
N
L
T
G
V
F
R
V
T
K
Q
V
L
K
AG
G
M
L
E
R
G
T
G
R
I
V
N
I
A
S
T
G
G
K
Q
G
V
V
H
A
A
P
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
V
C
P
G
F
V
E
T
P
-
M
----
A
A
S
V
R
E
H
Y
S
D
IW
E
V
S
T
E
E
-----------------
A
F
D
R
I
T
A
R
V
P
I
-
G
R
Y
V
---
Q
P
S
E
V
A
E
--------------------------------------------------
119
HHSearch
78.20
30%
-97
- C1 -
3AI3
3
?
A:
[3-251]
----
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
----
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
-
R
Q
V
-
D
R
L
H
E
A
A
R
S
L
K
E
K
F
-
G
V
R
V
L
E
--
V
A
V
D
V
A
T
P
-
E
-
G
V
D
A
V
V
E
S
V
-----
R
S
S
FG
G
A
D
I
----
L
---
V
N
N
A
G
T
G
S
-
N
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
-
L
L
V
M
A
A
V
R
L
A
R
G
L
V
P
--
G
M
R
A
R
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
L
I
L
T
P
-
D
----
W
-----------
I
K
T
A
K
E
L
T
K
DNGGD
W
K
G
Y
L
Q
S
V
A
D
E
H
-----
A
P
I
K
R
F
-
A
---
S
P
E
E
L
A
N
F
F
V
F
L
C
S
E
R
-
A
T
Y
S
V
G
S
---------------------------------
58
PsiBlast_CBE
76.77
31%
-103
- C1 -
2RH4
1
ACT3_STRCO
B:
[20-250]
------
Q
D
S
E
V
A
L
V
T
G
A
T
S
G
I
G
----
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
-
R
G
E
-
E
G
L
R
T
T
L
K
E
L
R
E
----
A
G
V
E
A
---
D
G
R
T
C
D
V
-
R
-
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
--
P
V
D
V
----
L
---
V
N
N
A
G
R
P
G
-
G
G
A
T
A
E
L
A
D
E
L
W
L
D
V
V
E
-
T
N
L
T
G
V
F
R
V
T
K
Q
V
L
K
AG
G
M
L
E
R
G
T
G
R
I
V
N
I
A
S
T
G
G
K
Q
G
V
V
H
A
A
P
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
V
C
P
G
F
V
E
T
P
-
M
----
A
A
S
V
R
E
H
Y
S
D
I
W
E
V
S
T
E
E
-----------------
A
F
D
R
I
T
A
R
V
P
I
-
G
R
Y
V
---
Q
P
S
E
V
A
E
--------------------------------------------------
18
PsiBlast_PDB
76.54
32%
-104
- C1 -
3QRW
2
ACT3_STRCO
A:
[25-254]
-------
D
S
E
V
A
L
V
T
G
A
T
S
G
I
G
----
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
-
R
G
E
-
E
G
L
R
T
T
L
K
E
L
R
E
----
A
G
V
E
A
D
G
R
T
C
D
V
R
S
V
P
E
-
I
E
A
L
V
A
A
V
V
E
----
R
Y
G
--
P
V
D
V
----
L
---
V
N
N
A
G
R
L
G
-
G
G
A
T
A
E
L
A
D
E
L
W
L
D
V
V
E
-
T
N
L
T
G
V
F
R
V
T
K
Q
V
L
K
AG
G
M
L
E
R
G
T
G
R
I
V
N
I
A
S
T
G
G
K
Q
G
V
V
H
A
A
P
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
V
C
P
G
F
V
E
T
P
-
M
----
A
A
S
V
R
E
H
Y
S
D
I
W
E
V
S
T
E
E
-----------------
A
F
D
R
I
T
A
R
V
P
I
-
G
R
Y
V
---
Q
P
S
E
V
A
E
--------------------------------------------------
17
PsiBlast_PDB
76.43
32%
-105
- C1 -
3CSD
3
ACT3_STRCO
B:
[24-254]
------
Q
D
S
E
V
A
L
V
T
G
A
T
S
G
I
G
----
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
-
R
G
E
-
E
G
L
R
T
T
L
K
E
L
R
E
----
A
G
V
E
A
D
G
R
T
C
D
V
R
S
V
P
E
-
I
E
A
L
V
A
A
V
V
E
----
R
Y
G
--
P
V
D
V
----
L
---
V
N
N
A
G
R
L
G
-
G
G
A
T
A
E
L
A
D
E
L
W
L
D
V
V
E
-
T
N
L
T
G
V
F
R
V
T
K
Q
V
L
K
AG
G
M
L
E
R
G
T
G
R
I
V
N
I
A
S
T
G
G
K
Q
G
V
V
H
A
A
P
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
V
C
P
G
F
V
E
T
P
-
M
----
A
A
S
V
REH--------
T
E
E
-----------------
A
F
D
R
I
T
A
R
V
P
I
-
G
R
Y
V
---
Q
P
S
E
V
A
E
--------------------------------------------------
19
PsiBlast_PDB
75.89
32%
-106
- C1 -
3RI3
3
ACT3_STRCO
B:
[24-254]
------
Q
D
S
E
V
A
L
V
T
G
A
T
S
G
I
G
----
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
-
R
G
E
-
E
G
L
R
T
T
L
K
E
L
R
E
----
A
G
V
E
A
D
G
R
T
C
D
V
R
S
V
P
E
-
I
E
A
L
V
A
A
V
V
E
----
R
Y
G
--
P
V
D
V
----
L
---
V
N
N
A
G
R
L
G
-
G
G
A
T
A
E
L
A
D
E
L
W
L
D
V
V
E
-
T
N
L
T
G
V
F
R
V
T
K
Q
V
L
K
AG
G
M
L
E
R
G
T
G
R
I
V
N
I
A
S
T
G
G
K
Q
G
V
V
H
A
A
P
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
V
C
P
G
F
V
E
T
P
-
M
----
A
A
S
V
REH--------
T
E
E
-----------------
A
F
D
R
I
T
A
R
V
P
I
-
G
R
Y
V
---
Q
P
S
E
V
A
E
--------------------------------------------------
16
PsiBlast_PDB
75.82
31%
-103
- C1 -
2RHC
1
ACT3_STRCO
B:
[20-250]
------
Q
D
S
E
V
A
L
V
T
G
A
T
S
G
I
G
----
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
-
R
G
E
-
E
G
L
R
T
T
L
K
E
L
R
E
----
A
G
V
E
A
---
D
G
R
T
C
D
V
-
R
-
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
--
P
V
D
V
----
L
---
V
N
N
A
G
R
P
G
-
G
G
A
T
A
E
L
A
D
E
L
W
L
D
V
V
E
-
T
N
L
T
G
V
F
R
V
T
K
Q
V
L
K
AG
G
M
L
E
R
G
T
G
R
I
V
N
I
A
S
T
G
G
K
Q
G
V
V
H
A
A
P
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
V
C
P
G
F
V
E
T
P
-
M
----
A
A
S
V
R
E
H
Y
S
D
I
W
E
V
S
T
E
E
-----------------
A
F
D
R
I
T
A
R
V
P
I
-
G
R
Y
V
---
Q
P
S
E
V
A
E
--------------------------------------------------
14
PsiBlast_PDB
73.13
31%
-100
- C1 -
1W4Z
5
ACT3_STRCO
A:
[24-254]
------
Q
D
S
E
V
A
L
V
T
G
A
T
S
G
I
G
----
L
E
I
A
R
R
L
G
K
E
G
L
R
V
F
V
C
A
-
R
G
E
-
E
G
L
R
T
T
L
K
E
L
R
E
----
A
G
V
E
A
---
D
G
R
T
C
D
V
-
R
-
S
V
P
E
I
E
A
L
V
A
A
V
V
E
R
Y
G
--
P
V
D
V
----
L
---
V
N
N
A
G
R
P
G
-
G
G
A
T
A
E
L
A
D
E
L
W
L
D
V
V
E
-
T
N
L
T
G
V
F
R
V
T
K
Q
V
L
K
AG
G
M
L
E
R
G
T
G
R
I
V
N
I
A
S
T
G
G
K
Q
G
V
V
H
A
A
P
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
V
C
P
G
F
V
E
T
P
-
M
----
A
A
S
V
R
E
H
Y
S
D
I
W
E
V
S
T
E
E
-----------------
A
F
D
R
I
T
A
R
V
P
I
-
G
R
Y
V
---
Q
P
S
E
V
A
E
--------------------------------------------------
71
PsiBlast_CBE
70.03
36%
-97
- C1 -
2JAP
2
?
D:
[11-223]
------------
L
I
T
G
A
S
S
G
I
G
----
E
A
T
A
R
A
L
A
A
E
G
A
A
V
A
I
A
A
-
R
R
V
-
E
K
L
R
A
L
G
D
E
L
T
A
A
G
-
A
-
K
V
H
V
--
L
E
L
D
V
A
D
R
-
Q
G
V
D
A
A
V
A
S
T
V
-------
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
M
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
-
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
--
H
L
L
-
R
S
K
G
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
G
V
R
V
V
V
I
E
P
G
T
T
D
T
E
-
L
RGHI
T
-----------
H
T
A
T
K
E
-----------------
M
Y
E
-----
Q
R
I
-
S
Q
-
I
RKL
Q
A
Q
D
I
A
E
A
-------------------------------------------------
51
PsiBlast_CBE
69.72
32%
-112
- C1 -
3RKU
1
YM71_YEAST
D:
[33-226]
--------
K
K
T
V
L
I
T
G
A
S
A
G
I
G
KATA
L
E
Y
L
E
A
S
N
G
-
D
M
K
L
I
L
A
A
-
R
R
L
-
E
K
L
E
E
L
K
K
T
I
D
Q
E
F
P
N
A
K
V
H
V
--
A
Q
L
D
I
T
Q
A
-
E
-
K
I
K
P
F
I
E
N
L
-----
P
Q
E
FK
D
I
D
I
----
L
---
V
N
N
A
G
K
A
L
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
-
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
--
I
F
Q
A
K
N
S
G
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
T
K
I
R
V
I
L
I
A
P
G
L
V
E
T
E
-
F
----
S
--------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
69.57
32%
-112
- C1 -
3RKU
1
YM71_YEAST
C:
[33-226]
--------
K
K
T
V
L
I
T
G
A
S
A
G
I
G
KATA
L
E
Y
L
E
A
S
N
G
-
D
M
K
L
I
L
A
A
-
R
R
L
-
E
K
L
E
E
L
K
K
T
I
D
Q
E
F
P
N
A
K
V
H
V
--
A
Q
L
D
I
T
Q
A
-
E
-
K
I
K
P
F
I
E
N
L
-----
P
Q
E
FK
D
I
D
I
----
L
---
V
N
N
A
G
K
A
L
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
-
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
--
I
F
Q
A
K
N
S
G
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
T
K
I
R
V
I
L
I
A
P
G
L
V
E
T
E
-
F
----
S
--------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
69.29
36%
-98
- C1 -
2JAP
2
?
B:
[11-223]
------------
L
I
T
G
A
S
S
G
I
G
----
E
A
T
A
R
A
L
A
A
E
G
A
A
V
A
I
A
A
-
R
R
V
-
E
K
L
R
A
L
G
D
E
L
T
A
A
G
-
A
-
K
V
H
V
--
L
E
L
D
V
A
D
R
-
Q
G
V
D
A
A
V
A
S
T
V
-------
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
M
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
-
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
--
H
L
L
-
R
S
K
G
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
G
V
R
V
V
V
I
E
P
G
T
T
D
T
E
-
L
RGHI
T
-----------
H
T
A
T
K
E
-----------------
M
Y
E
-----
Q
R
I
-
S
Q
-
I
RKL
Q
A
Q
D
I
A
E
A
-------------------------------------------------
10
PsiBlast_PDB
68.76
32%
-111
- C1 -
3RKU
1
YM71_YEAST
A:
[33-226]
--------
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
N
G
-
D
M
K
L
I
L
A
A
-
R
R
L
-
E
K
L
E
E
L
K
K
T
I
D
Q
E
F
P
N
A
K
V
H
V
--
A
Q
L
D
I
T
Q
A
-
E
-
K
I
K
P
F
I
E
N
L
-----
P
Q
E
FK
D
I
D
I
----
L
---
V
N
N
A
G
K
A
L
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
-
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
--
I
F
Q
A
K
N
S
G
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
T
K
I
R
V
I
L
I
A
P
G
L
V
E
T
E
-
F
----
S
--------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
68.54
36%
-97
- C1 -
2JAP
2
?
C:
[11-223]
------------
L
I
T
G
A
S
S
G
I
G
----
E
A
T
A
R
A
L
A
A
E
G
A
A
V
A
I
A
A
-
R
R
V
-
E
K
L
R
A
L
G
D
E
L
T
A
A
G
-
A
-
K
V
H
V
--
L
E
L
D
V
A
D
R
-
Q
G
V
D
A
A
V
A
S
T
V
-------
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
M
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
-
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
--
H
L
L
-
R
S
K
G
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
G
V
R
V
V
V
I
E
P
G
T
T
D
T
E
-
L
RGHI
T
-----------
H
T
A
T
K
E
-----------------
M
Y
E
-----
Q
R
I
-
S
Q
-
I
RKL
Q
A
Q
D
I
A
E
A
-------------------------------------------------
74
PsiBlast_CBE
68.37
36%
-98
- C1 -
2JAP
2
?
A:
[11-223]
------------
L
I
T
G
A
S
S
G
I
G
----
E
A
T
A
R
A
L
A
A
E
G
A
A
V
A
I
A
A
-
R
R
V
-
E
K
L
R
A
L
G
D
E
L
T
A
A
G
-
A
-
K
V
H
V
--
L
E
L
D
V
A
D
R
-
Q
G
V
D
A
A
V
A
S
T
V
-------
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
M
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
-
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
--
H
L
L
-
R
S
K
G
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
G
V
R
V
V
V
I
E
P
G
T
T
D
T
E
-
L
RGHI
T
-----------
H
T
A
T
K
E
-----------------
M
Y
E
-----
Q
R
I
-
S
Q
-
I
RKL
Q
A
Q
D
I
A
E
A
-------------------------------------------------
53
PsiBlast_CBE
67.90
32%
-111
- C1 -
3RKU
1
YM71_YEAST
B:
[33-226]
--------
K
K
T
V
L
I
T
G
A
S
A
G
I
G
KATA
L
E
Y
L
E
A
S
N
G
-
D
M
K
L
I
L
A
A
-
R
R
L
-
E
K
L
E
E
L
K
K
T
I
D
Q
E
F
P
N
A
K
V
H
V
--
A
Q
L
D
I
T
Q
A
-
E
-
K
I
K
P
F
I
E
N
L
-----
P
Q
E
FK
D
I
D
I
----
L
---
V
N
N
A
G
K
A
L
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
-
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
--
I
F
Q
A
K
N
S
G
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
T
K
I
R
V
I
L
I
A
P
G
L
V
E
T
E
-
F
----
S
--------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
66.17
31%
-114
- C1 -
2ZTL
2
?
B:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
-
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
--
D
G
A
D
L
S
K
G
-
E
-
A
V
R
G
L
V
D
N
A
VR---
Q
M
G
--
R
I
D
I
----
L
---
V
N
N
A
G
I
Q
H
-
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
64.94
31%
-112
- C1 -
2ZTL
2
?
A:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
-
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
--
D
G
A
D
L
S
K
G
-
E
-
A
V
R
G
L
V
D
N
A
V
R
---
Q
M
G
--
R
I
D
I
----
L
---
V
N
N
A
G
I
Q
H
-
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
64.58
31%
-110
- C1 -
2ZTV
2
?
C:
[8-195]
------------
V
V
T
G
S
T
S
G
I
G
----
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
-
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
--
D
G
A
D
L
S
K
G
-
E
-
A
V
R
G
L
V
D
N
A
V
R
---
Q
M
G
--
R
I
D
I
----
L
---
V
N
N
A
G
I
Q
H
-
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
63.51
31%
-111
- C1 -
2ZTL
3
?
D:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
-
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
--
D
G
A
D
L
S
K
G
-
E
-
A
V
R
G
L
V
D
N
A
VR---
Q
M
G
--
R
I
D
I
----
L
---
V
N
N
A
G
I
Q
H
-
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
63.31
31%
-114
- C1 -
2ZTV
3
?
D:
[8-197]
------------
V
V
T
G
S
T
S
G
I
G
----
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
-
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
--
D
G
A
D
L
S
K
G
-
E
-
A
V
R
G
L
V
D
N
A
VR---
Q
M
G
--
R
I
D
I
----
L
---
V
N
N
A
G
I
Q
H
-
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
62.92
31%
-110
- C1 -
2ZTL
2
?
C:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
-
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
--
D
G
A
D
L
S
K
G
-
E
-
A
V
R
G
L
V
D
N
A
VR---
Q
M
G
--
R
I
D
I
----
L
---
V
N
N
A
G
I
Q
H
-
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
62.58
33%
-104
- C1 -
3UF0
1
?
A:
[33-213]
----------
T
A
V
V
T
G
A
G
S
G
I
G
----
R
A
I
A
H
G
Y
A
-
R
A
G
A
H
V
L
A
W
-
G
R
T
-
D
G
V
K
E
V
A
D
E
I
-
A
D
G
-
G
G
S
A
E
A
--
V
V
A
D
L
A
D
L
-
E
-
G
A
A
N
V
A
E
E
L
A
A
T
R
-
R
V
D
--
V
-------
L
---
V
N
N
A
G
I
I
A
-
R
A
P
A
E
E
V
S
L
G
R
W
R
E
V
L
T
-
V
N
L
D
A
A
W
V
L
S
R
S
F
G
T
--
A
M
L
A
H
G
S
G
R
I
V
T
I
A
S
M
L
S
F
Q
G
G
R
N
V
A
A
Y
A
A
S
K
H
A
V
V
G
L
T
R
A
L
A
S
E
W
A
G
R
G
V
G
V
N
A
L
A
P
G
Y
V
V
T
----------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
62.21
31%
-104
- C1 -
3VDQ
4
?
C:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
-
F
G
Q
P
E
D
I
E
R
E
R
S
T
L
E
S
K
F
-
G
V
K
A
Y
Y
--
L
N
A
D
L
S
D
A
-
Q
-
A
T
R
D
F
I
A
K
------
A
A
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
Q
H
-
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
61.91
31%
-103
- C1 -
3W8D
6
?
A:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
-
F
G
Q
P
E
D
I
E
R
E
R
S
T
L
E
S
K
F
-
G
V
K
A
Y
Y
--
L
N
A
D
L
S
D
A
-
Q
-
A
T
R
D
F
I
A
K
------
A
A
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
Q
H
-
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
61.51
31%
-100
- C1 -
3W8E
3
?
A:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
-
F
G
Q
P
E
D
I
E
R
E
R
S
T
L
E
S
K
F
-
G
V
K
A
Y
Y
--
L
N
A
D
L
S
D
A
-
Q
-
A
T
R
D
F
I
A
K
------
A
A
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
Q
H
-
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
61.30
31%
-113
- C1 -
2ZTV
2
?
B:
[8-204]
------------
V
V
T
G
S
T
S
G
I
G
----
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
G
D
A
-
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
--
D
G
A
D
L
S
K
G
-
E
-
A
V
R
G
L
V
D
N
A
V
R
---
Q
M
G
--
R
I
D
I
----
L
---
V
N
N
A
G
I
Q
H
-
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
61.03
31%
-100
- C1 -
3VDQ
4
?
B:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
-
F
G
Q
P
E
D
I
E
R
E
R
S
T
L
E
S
K
F
-
G
V
K
A
Y
Y
--
L
N
A
D
L
S
D
A
-
Q
-
A
T
R
D
F
I
A
K
------
A
A
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
Q
H
-
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
60.69
31%
-99
- C1 -
3W8F
3
?
A:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
-
F
G
Q
P
E
D
I
E
R
E
R
S
T
L
E
S
K
F
-
G
V
K
A
Y
Y
--
L
N
A
D
L
S
D
A
-
Q
-
A
T
R
D
F
I
A
K
------
A
A
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
Q
H
-
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
60.64
31%
-102
- C1 -
3VDR
4
?
D:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
-
F
G
Q
P
E
D
I
E
R
E
R
S
T
L
E
S
K
F
-
G
V
K
A
Y
Y
--
L
N
A
D
L
S
D
A
-
Q
-
A
T
R
D
F
I
A
K
------
A
A
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
Q
H
-
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
59.36
31%
-99
- C1 -
3VDQ
4
?
D:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
-
F
G
Q
P
E
D
I
E
R
E
R
S
T
L
E
S
K
F
-
G
V
K
A
Y
Y
--
L
N
A
D
L
S
D
A
-
Q
-
A
T
R
D
F
I
A
K
------
A
A
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
Q
H
-
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
59.34
31%
-99
- C1 -
3VDQ
4
?
A:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
-
F
G
Q
P
E
D
I
E
R
E
R
S
T
L
E
S
K
F
-
G
V
K
A
Y
Y
--
L
N
A
D
L
S
D
A
-
Q
-
A
T
R
D
F
I
A
K
------
A
A
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
Q
H
-
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
58.50
31%
-98
- C1 -
3VDR
4
?
B:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
-
F
G
Q
P
E
D
I
E
R
E
R
S
T
L
E
S
K
F
-
G
V
K
A
Y
Y
--
L
N
A
D
L
S
D
A
-
Q
-
A
T
R
D
F
I
A
K
------
A
A
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
Q
H
-
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
58.45
31%
-96
- C1 -
3VDR
4
?
A:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
-
F
G
Q
P
E
D
I
E
R
E
R
S
T
L
E
S
K
F
-
G
V
K
A
Y
Y
--
L
N
A
D
L
S
D
A
-
Q
-
A
T
R
D
F
I
A
K
------
A
A
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
Q
H
-
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
57.56
31%
-99
- C1 -
3VDR
3
?
C:
[8-190]
------------
V
V
T
G
S
T
S
G
I
G
----
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
-
F
G
Q
P
E
D
I
E
R
E
R
S
T
L
E
S
K
F
-
G
V
K
A
Y
Y
--
L
N
A
D
L
S
D
A
-
Q
-
A
T
R
D
F
I
A
K
------
A
A
E
--
A
L
G
G
----
L
DIL
V
N
N
A
G
I
Q
H
-
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
-
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
--
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
----------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
57.05
37%
-107
- C1 -
3P19
1
?
D:
[19-195]
-----------
V
V
I
T
G
A
S
S
G
I
G
----
E
A
I
A
R
R
F
S
E
E
G
H
P
L
L
L
L
A
-
R
R
V
-
E
R
L
K
A
L
--
N
L
P
N
T
L
-
C
A
Q
V
D
V
--
T
D
K
Y
T
F
D
T
-
A
-
I
-------
T
-----
R
A
E
--
K
I
Y
G
PADA
I
---
V
N
N
A
G
M
M
L
-
L
G
Q
I
-
D
T
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
--
P
M
K
A
R
N
C
G
T
I
I
N
I
S
S
I
A
G
K
K
T
F
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
A
S
N
V
R
V
M
T
I
A
P
S
A
V
K
T
E
---------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
55.60
37%
-107
- C1 -
3P19
1
?
C:
[19-213]
-----------
V
V
I
T
G
A
S
S
G
I
G
----
E
A
I
A
R
R
F
S
E
E
G
H
P
L
L
L
L
A
-
R
R
V
-
E
R
L
K
A
L
--
N
L
P
N
T
L
-
C
A
Q
V
D
V
--
T
D
K
Y
T
F
D
T
-
A
-
I
-------
T
-----
R
A
E
--
K
I
Y
G
PADA
I
---
V
N
N
A
G
M
M
L
-
L
G
Q
I
-
D
T
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
--
P
M
K
A
R
N
C
G
T
I
I
N
I
S
S
I
A
G
K
K
T
F
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
A
S
N
V
R
V
M
T
I
A
P
S
A
V
K
T
E
---------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
55.45
37%
-109
- C1 -
3P19
1
?
B:
[19-213]
-----------
V
V
I
T
G
A
S
S
G
I
G
----
E
A
I
A
R
R
F
S
E
E
G
H
P
L
L
L
L
A
-
R
R
V
-
E
R
L
K
A
L
--
N
L
P
N
T
L
-
C
A
Q
V
D
V
--
T
D
K
Y
T
F
D
T
-
A
-
I
-------
T
-----
R
A
E
--
K
I
Y
G
PAD
A
I
---
V
N
N
A
G
M
M
L
-
L
G
Q
I
-
D
T
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
--
P
M
K
A
R
N
C
G
T
I
I
N
I
S
S
I
A
G
K
K
T
F
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
A
S
N
V
R
V
M
T
I
A
P
S
A
V
K
T
E
---------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
54.54
37%
-105
- C1 -
3P19
1
?
A:
[19-195]
-----------
V
V
I
T
G
A
S
S
G
I
G
----
E
A
I
A
R
R
F
S
E
E
G
H
P
L
L
L
L
A
-
R
R
V
-
E
R
L
K
A
L
--
N
L
P
N
T
L
-
C
A
Q
V
D
V
--
T
D
K
Y
T
F
D
T
-
A
-
I
-------
T
-----
R
A
E
--
K
I
Y
G
PADA
I
---
V
N
N
A
G
M
M
L
-
L
G
Q
I
-
D
T
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
--
P
M
K
A
R
N
C
G
T
I
I
N
I
S
S
I
A
G
K
K
T
F
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
A
S
N
V
R
V
M
T
I
A
P
S
A
V
K
T
E
---------------------------------------------------------------------------------------------------------------------