@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1568: (2016-05-03 )
MAAATGGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGAWLTLIRDGQPIEVLDAMSSWWTAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEPAARLAKLLVDITPAGLDTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGDTFLAMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPVVQGAGGMRFHDPRYLHDLRDICRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCVGKALTGGYLSLAATLCTADVAHTISAGAAGALMHGPTFMANPLACAVSVASVELLLGQDWRTRITELAAGLTAGLDTARALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWLRPFRNLVYAMPPYICTPAEITQITSAMVEVARLVGSLP
Atome Classification :
(59 SA)
.........10........20........30-........40........50-.........60........70........80-.........90........100.......110.......120.......130.......140..-.....150.......160.......170.......180.......-----------190.---------......200....----------...210.......220........230.......240.......250.......260.......270...--....280.......290.......300.......--310-........320.......330.......340.......350.......360-.......----370.......380---...-----------.....390.---......400........410.......420.......430.....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAAATGGL
T
P
E
Q
I
I
A
VDGAHLW
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
AAH
G
A
W
L
T
L
IR--DGQ
P
I
E
V
L
D
A
M
S
S
W
W
T
A
IHGHGH
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
FGGLT
H
E
P
A
A
R
L
A
K
L
L
V
DITPAG
L
D
T
V
F
FSDSG
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
RGRGL-PGKR
R
L
M
TWRGGYHG
D
T
F
L
A
M
S
I
CDPHG
G
M
H
S
L
W
T
D
V
L
A
A
Q
VFAP-----------QVPR---------DYD
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
QGAGGMRFH
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
TGFGRT
G
A
L
F
AADHAGVS--PD
I
M
C
V
GKALT
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
ISAGA--AG--ALMHGPTFMAN
P
L
A
C
A
V
S
V
A
S
V
E
L
L
LG
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
AGL
D
T
A
RAL-PAVT
D
V
R
----
V
C
GAI
G
V
I
ECDR----PV
D
-----------
L
A
VA
T
P
A
A
L---DRG
V
W
L
R
P
-
F
R
N
L
V
YAMPPYIC
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
VGSLP-
10
PsiBlast_PDB
98.11
100%
-136
- C2 -
4WYE
7
BIOA_MYCTU
A:
[28-456]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
37
PsiBlast_CBE
97.52
100%
-136
- C2 -
4MQP
4
BIOA_MYCTU
B:
[28-454]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
----
11
PsiBlast_PDB
97.49
100%
-137
- C2 -
4WYF
3
BIOA_MYCTU
A:
[28-455]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
4
PsiBlast_PDB
97.23
100%
-136
- C2 -
4MQQ
7
BIOA_MYCTU
A:
[28-455]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
26
PsiBlast_CBE
97.10
100%
-136
- C2 -
4WYG
14
BIOA_MYCTU
B:
[28-456]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
15
PsiBlast_PDB
97.06
100%
-137
- C2 -
4WYD
13
BIOA_MYCTU
A:
[28-457]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
P
-
7
PsiBlast_PDB
96.97
100%
-136
- C2 -
4CXR
6
BIOA_MYCTU
A:
[28-455]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
----
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
21
PsiBlast_CBE
96.78
100%
-138
- C2 -
4XJP
9
BIOA_MYCTU
B:
[28-456]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
3
PsiBlast_PDB
96.66
100%
-137
- C2 -
4MQP
4
BIOA_MYCTU
A:
[28-455]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
12
PsiBlast_PDB
96.55
100%
-135
- C2 -
4WYG
10
BIOA_MYCTU
A:
[28-456]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
1
PsiBlast_PDB
96.52
100%
-137
- C2 -
3TFT
3
BIOA_MYCTU
A:
[28-453]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-----
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----
34
PsiBlast_CBE
96.51
100%
-137
- C2 -
4W1X
5
BIOA_MYCTU
B:
[27-455]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
46
PsiBlast_CBE
96.21
100%
-137
- C2 -
4W1V
5
BIOA_MYCTU
A:
[2-429]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
----
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
8
PsiBlast_PDB
96.21
100%
-136
- C2 -
4W1X
7
BIOA_MYCTU
A:
[28-456]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
45
PsiBlast_CBE
96.13
100%
-135
- C2 -
4W1V
9
BIOA_MYCTU
B:
[1-429]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
39
PsiBlast_CBE
96.08
100%
-134
- C2 -
4CXQ
7
BIOA_MYCTU
B:
[28-455]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
---
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
6
PsiBlast_PDB
96.03
100%
-136
- C2 -
4CXQ
8
BIOA_MYCTU
A:
[28-455]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
--
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
36
PsiBlast_CBE
95.99
100%
-134
- C2 -
4MQQ
4
BIOA_MYCTU
B:
[27-454]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
----
9
PsiBlast_PDB
95.95
100%
-135
- C2 -
4WYC
7
BIOA_MYCTU
A:
[28-455]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
5
PsiBlast_PDB
95.94
100%
-137
- C2 -
4MQR
4
BIOA_MYCTU
A:
[28-455]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
25
PsiBlast_CBE
95.90
100%
-133
- C2 -
4XEW
4
BIOA_MYCTU
B:
[28-455]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
30
PsiBlast_CBE
95.86
100%
-135
- C2 -
4WYC
8
BIOA_MYCTU
B:
[27-455]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
18
PsiBlast_PDB
95.81
100%
-137
- C2 -
4XJO
5
BIOA_MYCTU
A:
[28-455]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
102
HHSearch
95.78
99%
-135
- C2 -
4WYD
13
BIOA_MYCTU
A:
[28-456]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
DG
Q
P
I
--
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
35
PsiBlast_CBE
95.76
100%
-138
- C2 -
4MQR
4
BIOA_MYCTU
B:
[27-455]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
20
PsiBlast_PDB
95.74
99%
-136
- C2 -
3LV2
3
BIOA_MYCTU
A:
[32-462]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
---------
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
----
L
M
R
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
P
-
22
PsiBlast_CBE
95.72
100%
-137
- C2 -
4XJO
5
BIOA_MYCTU
B:
[28-456]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
38
PsiBlast_CBE
95.67
100%
-135
- C2 -
4CXR
5
BIOA_MYCTU
B:
[27-453]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----
13
PsiBlast_PDB
95.65
100%
-135
- C2 -
4XEW
4
BIOA_MYCTU
A:
[28-455]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
19
PsiBlast_PDB
95.51
100%
-137
- C2 -
4XJP
7
BIOA_MYCTU
A:
[28-456]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
29
PsiBlast_CBE
95.40
100%
-134
- C2 -
4WYD
10
BIOA_MYCTU
B:
[27-456]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
27
PsiBlast_CBE
95.39
100%
-136
- C2 -
4WYF
3
BIOA_MYCTU
B:
[28-453]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----
48
PsiBlast_CBE
95.38
100%
-135
- C2 -
4W1W
9
BIOA_MYCTU
A:
[1-429]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
41
PsiBlast_CBE
95.35
100%
-135
- C2 -
3TFT
3
BIOA_MYCTU
B:
[27-453]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
----
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----
17
PsiBlast_PDB
95.34
100%
-135
- C2 -
4XJM
4
BIOA_MYCTU
A:
[28-456]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
47
PsiBlast_CBE
95.17
100%
-137
- C2 -
4W1W
8
BIOA_MYCTU
B:
[1-428]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
28
PsiBlast_CBE
95.11
100%
-133
- C2 -
4WYE
7
BIOA_MYCTU
B:
[27-455]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
16
PsiBlast_PDB
94.87
100%
-135
- C2 -
4XJL
5
BIOA_MYCTU
A:
[28-456]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
2
PsiBlast_PDB
94.68
100%
-135
- C2 -
3TFU
3
BIOA_MYCTU
A:
[27-453]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
----------
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----
40
PsiBlast_CBE
94.55
100%
-139
- C2 -
3TFU
3
BIOA_MYCTU
B:
[27-453]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
------
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
----------
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----
43
PsiBlast_CBE
94.48
99%
-136
- C2 -
3BV0
2
BIOA_MYCTU
B:
[6-436]
-----
G
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
----------
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
------------
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
23
PsiBlast_CBE
94.46
100%
-134
- C2 -
4XJM
4
BIOA_MYCTU
B:
[28-456]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
24
PsiBlast_CBE
94.33
100%
-134
- C2 -
4XJL
5
BIOA_MYCTU
B:
[28-456]
-------
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
E
-
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
--
42
PsiBlast_CBE
94.05
99%
-136
- C2 -
3LV2
3
BIOA_MYCTU
B:
[31-460]
-----
G
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
----------
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
------
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
A
--
A
G
--
A
L
M
R
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
---
44
PsiBlast_CBE
93.43
99%
-138
- C2 -
3BV0
2
BIOA_MYCTU
A:
[7-433]
------
G
L
T
P
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
----------
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
--
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
--
T
T
Q
L
R
V
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
P
A
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
-
P
G
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
-----------
Q
V
P
R
---------
D
Y
D
P
A
Y
S
A
A
F
E
A
Q
----------
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
G
------------
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
L
-
P
A
V
T
D
V
R
----
V
C
G
A
I
G
V
I
E
C
D
R
----
P
V
D
-----------
L
A
V
A
T
P
A
A
L
---
D
R
G
V
W
L
R
P
-
F
R
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-----
50
PsiBlast_CBE
74.40
50%
-126
- C2 -
1QJ3
5
BIOA_ECOLI
B:
[6-417]
-------------
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
P
L
P
V
Y
P
V
V
S
--
A
E
G
C
E
L
I
L
-
S
--
D
G
R
--
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
--
K
S
Q
I
D
A
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
--
E
A
R
Q
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
---------
L
P
E
N
L
F
A
P
APQS-------
R
M
-----------
E
W
D
E
R
D
M
V
G
F
A
R
L
----------
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
----
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
----
V
L
G
A
I
G
V
V
E
T
T
H
----
P
V
N
-----------
M
A
A
L
Q
K
F
F
V
---
E
Q
G
V
W
I
R
P
-
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
------------
57
PsiBlast_CBE
74.17
50%
-123
- C2 -
1MGV
7
BIOA_ECOLI
B:
[6-417]
-------------
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
P
L
P
V
Y
P
V
V
S
--
A
E
G
C
E
L
I
L
-
S
--
D
G
R
--
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
--
K
S
Q
I
D
A
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
--
E
A
R
Q
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
APQS-------
R
M
D
G
---------
E
W
D
E
R
D
M
V
G
F
A
R
L
----------
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
--
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
----
V
L
G
A
I
G
V
V
E
T
T
H
----
P
V
N
-----------
M
A
A
L
Q
K
F
F
V
---
E
Q
G
V
W
I
A
P
-
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
------------
52
PsiBlast_CBE
73.89
50%
-126
- C2 -
1MLY
4
BIOA_ECOLI
B:
[6-417]
-------------
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
P
L
P
V
Y
P
V
V
S
--
A
E
G
C
E
L
I
L
-
S
--
D
G
R
--
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
--
K
S
Q
I
D
A
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
--
E
A
R
Q
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
APQS-------
R
M
D
G
---------
E
W
D
E
R
D
M
V
G
F
A
R
L
----------
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
--
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
----
V
L
G
A
I
G
V
V
E
T
T
H
----
P
V
N
-----------
M
A
A
L
Q
K
F
F
V
---
E
Q
G
V
W
I
R
P
-
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
------------
49
PsiBlast_CBE
73.85
50%
-124
- C2 -
1QJ5
3
BIOA_ECOLI
B:
[6-417]
-------------
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
P
L
P
V
Y
P
V
V
S
--
A
E
G
C
E
L
I
L
-
S
--
D
G
R
--
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
--
K
S
Q
I
D
A
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
--
E
A
R
Q
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
APQS-------
R
M
D
G
---------
E
W
D
E
R
D
M
V
G
F
A
R
L
----------
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
--
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
----
V
L
G
A
I
G
V
V
E
T
T
H
----
P
V
N
-----------
M
A
A
L
Q
K
F
F
V
---
E
Q
G
V
W
I
R
P
-
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
------------
55
PsiBlast_CBE
73.67
50%
-126
- C2 -
1S07
4
BIOA_ECOLI
B:
[6-417]
-------------
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
P
L
P
V
Y
P
V
V
S
--
A
E
G
C
E
L
I
L
-
S
--
D
G
R
--
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
--
K
S
Q
I
D
A
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
--
E
A
R
Q
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
APQS-------
R
M
D
G
---------
E
W
D
E
R
D
M
V
G
F
A
R
L
----------
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
A
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
--
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
----
V
L
G
A
I
G
V
V
E
T
T
H
----
P
V
N
-----------
M
A
A
L
Q
K
F
F
V
---
E
Q
G
V
W
I
R
P
-
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
------------
56
PsiBlast_CBE
73.28
50%
-124
- C2 -
1S07
4
BIOA_ECOLI
A:
[6-417]
-------------
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
P
L
P
V
Y
P
V
V
S
--
A
E
G
C
E
L
I
L
-
S
--
D
G
R
--
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
--
K
S
Q
I
D
A
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
--
E
A
R
Q
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
APQS-------
R
M
D
G
---------
E
W
D
E
R
D
M
V
G
F
A
R
L
----------
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
A
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
--
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
----
V
L
G
A
I
G
V
V
E
T
T
H
----
P
V
N
-----------
M
A
A
L
Q
K
F
F
V
---
E
Q
G
V
W
I
R
P
-
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
------------
53
PsiBlast_CBE
73.28
50%
-125
- C2 -
1DTY
5
BIOA_ECOLI
B:
[6-417]
-------------
L
A
F
D
E
R
H
I
W
H
P
Y
T
S
M
T
S
P
L
P
V
Y
P
V
V
S
--
A
E
G
C
E
L
I
L
-
S
--
D
G
R
--
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
--
K
S
Q
I
D
A
M
S
H
V
M
F
G
E
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
G
--
E
A
R
D
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
APQS-------
R
M
D
G
---------
E
W
D
E
R
D
M
V
G
F
A
R
L
----------
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
D
G
E
--
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
----
V
L
G
A
I
G
V
V
E
T
T
H
----
P
V
N
-----------
M
A
A
L
Q
K
F
F
V
---
E
Q
G
V
W
I
R
P
-
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
------------
51
PsiBlast_CBE
73.27
50%
-127
- C2 -
1MLZ
4
BIOA_ECOLI
B:
[6-417]
-------------
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
P
L
P
V
Y
P
V
V
S
--
A
E
G
C
E
L
I
L
-
S
--
D
G
R
--
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
--
K
S
Q
I
D
A
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
--
E
A
R
Q
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
APQS-------
R
M
D
G
---------
E
W
D
E
R
D
M
V
G
F
A
R
L
----------
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
--
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
----
V
L
G
A
I
G
V
V
E
T
T
H
----
P
V
N
-----------
M
A
A
L
Q
K
F
F
V
---
E
Q
G
V
W
I
R
P
-
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
------------
58
PsiBlast_CBE
73.26
50%
-122
- C2 -
1MGV
5
BIOA_ECOLI
A:
[6-417]
-------------
L
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
P
L
P
V
Y
P
V
V
S
--
A
E
G
C
E
L
I
L
-
S
--
D
G
R
--
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
--
K
S
Q
I
D
A
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
--
E
A
R
Q
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
APQS-------
R
M
D
G
---------
E
W
D
E
R
D
M
V
G
F
A
R
L
----------
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
G
E
--
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
----
V
L
G
A
I
G
V
V
E
T
T
H
----
P
V
N
-----------
M
A
A
L
Q
K
F
F
V
---
E
Q
G
V
W
I
A
P
-
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
------------
54
PsiBlast_CBE
72.62
50%
-123
- C2 -
1DTY
5
BIOA_ECOLI
A:
[6-417]
-------------
L
A
F
D
E
R
H
I
W
H
P
Y
T
S
M
T
S
P
L
P
V
Y
P
V
V
S
--
A
E
G
C
E
L
I
L
-
S
--
D
G
R
--
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
--
K
S
Q
I
D
A
M
S
H
V
M
F
G
E
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
G
--
E
A
R
D
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
APQS-------
R
M
D
G
---------
E
W
D
E
R
D
M
V
G
F
A
R
L
----------
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
D
G
E
--
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
A
-
E
M
V
A
D
V
R
----
V
L
G
A
I
G
V
V
E
T
T
H
----
P
V
N
-----------
M
A
A
L
Q
K
F
F
V
---
E
Q
G
V
W
I
R
P
-
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
------------
124
Fugue
67.28
48%
-121
- C2 -
1DTY
5
BIOA_ECOLI
A:
[1-429]
--------
M
T
T
D
D
L
A
F
D
E
R
H
I
W
H
P
Y
T
S
M
T
S
P
-
L
P
V
Y
P
V
V
S
A
E
G
----
C
E
L
I
--
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
--
S
H
V
M
F
G
E
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
-
G
E-
A
R
D
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
APQSRMDGEWD---
E
---------
R
D
M
V
G
F
A
R
L
M
A
A
H
----------
R
H
----
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
--IA
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
D
G
E
--
A
G
--
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
-A
E
M
V
A
D
V
R
----
V
L
G
A
I
G
V
V
E
T
T
-HPVN--------------
M
A
A
L
Q
K
F
F
V
---
E
Q
G
V
W
I
R
P
F
-
G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
Q
103
HHSearch
62.07
33%
-119
- C2 -
3DOD
2
BIOK_BACSU
A:
[3-445]
----------
H
D
L
I
E
K
S
K
K
H
L
W
L
P
F
T
Q
M
K
D
Y
-
D
E
N
P
L
I
I
E
S
G
T
G
I
K
V
K
D
I
---
N
G
K
--
E
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
--
K
K
Q
L
G
K
I
A
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
P
K
K
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
N
I
G
K
-
P
E
K
Q
K
F
I
A
M
K
------------------------------
S
Y
K
A
P
-----------
I
P
Y
V
YRSESGD
P
D
E
C
R
D
Q
C
L
R
E
L
A
Q
L
----------
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
M
V
-
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
E
N
V
Q
--
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
D
D
Y
EN
L
K
--
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
A
E
K
S
K
K
L
H
F
L
L
Q
D
L
H
A
L
-
P
H
V
G
D
I
R
----
Q
L
G
F
M
C
G
A
E
L
V
R
----
S
K
E
TKEPYPADRR
I
G
Y
K
V
S
L
K
M
R
---
E
L
G
M
L
T
R
P
-
L
G
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
---
63
PsiBlast_CBE
56.33
32%
-112
- C2 -
3DOD
2
BIOK_BACSU
B:
[5-446]
------------
L
I
E
K
S
K
K
H
L
W
L
P
F
T
Q
M
K
D
Y
-
D
E
N
P
L
I
I
E
S
G
T
G
---
I
K
V
K
--
D
I
N
G
K
E
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
--
K
K
Q
L
G
K
I
A
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
P
K
K
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
N
I
G
K
-
P
E
K
Q
K
F
I
A
M
K
------------------------------
S
Y
K
A
P
------------
I
P
Y
---------
V
Y
R
S
E
S
G
D
P
D
E
C
R
D
Q
C
L
R
E
L
A
Q
L
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
-
M
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
E
N
V
Q
--
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
D
D
Y
--
E
N
LK
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
A
E
K
S
K
K
L
H
F
L
L
Q
D
L
H
A
L
-
P
H
V
G
D
I
R
Q
L
GF
M
C
G
A
E
L
V
R
S
K
E
T
KEPY
P
A
D
-----------
R
R
I
G
Y
K
V
S
L
K
M
R
E
L
G
M
L
T
R
P
-
L
G
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
L
--
64
PsiBlast_CBE
55.84
32%
-114
- C2 -
3DOD
2
BIOK_BACSU
A:
[5-446]
------------
L
I
E
K
S
K
K
H
L
W
L
P
F
T
Q
M
K
D
Y
-
D
E
N
P
L
I
I
E
S
G
T
G
---
I
K
V
K
--
D
I
N
G
K
E
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
--
K
K
Q
L
G
K
I
A
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
P
K
K
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
N
I
G
K
-
P
E
K
Q
K
F
I
A
M
K
------------------------------
S
Y
K
A
P
------------
I
P
Y
---------
V
Y
R
S
E
S
G
D
P
D
E
C
R
D
Q
C
L
R
E
L
A
Q
L
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
-
M
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
E
N
V
Q
--
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
D
D
Y
--
E
N
LK
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
A
E
K
S
K
K
L
H
F
L
L
Q
D
L
H
A
L
-
P
H
V
G
D
I
R
Q
L
GF
M
C
G
A
E
L
V
R
S
K
E
T
KEPY
P
A
D
-----------
R
R
I
G
Y
K
V
S
L
K
M
R
E
L
G
M
L
T
R
P
-
L
G
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
L
--