@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1569: (2016-05-03 )
MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELDLASNDYLGLSRHPAVIDGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGAAAGLLFSSGYTANLGAVVGLSGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVDAALRSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRGLLYELGLAGAPDVVMTTTLSKALGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAVGAARAALRVLQAEPWRPQAVLNHAGELARMCGVAAVPDSAMVSVILGEPESAVAAAAACLDAGVKVGCFRPPTVPAGTSRLRLTARASLNAGELELARRVLTDVLAVARR
Atome Classification :
(24 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110.......120-........130.......140.......150.......160.-....-..170--........180.......190.......200.......210..-.-....220....-...230.......240........250.......260.......270.......280....--...290----.--...-----.....300--.....----.---...-----310-----..----.------.....320.......330....-...340.......350.......360.......370.......380....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MKAATQARIDDS
P
L
A
W
L
D
A
V
Q
R
Q
R
H
E
A
G
L
R
R
CLRPRPA
V
A
T
E
L
DLASNDYLGLSRH
P
A
V
IDGG
V
Q
A
L
R
I
W
GAGATG
S
R
L
VTG
D
T
K
L
H
Q
Q
F
E
A
E
L
A
E
F
V
G
A
A
A
G
L
L
FSSGYTANL
G
A
V
V
GLS--GP
G
S
L
L
V
S
D
A
R
S
H
A
S
L
V
D
A
C
RLSR
A
R
V
V
V
TPHR
D
V
D
A
V
D
A
A
L
-RSRD-EQ
R
A
---
V
V
V
TDSVFSADG
S
L
A
P
V
R
E
L
L
E
V
C
R
RHG
A
L
L
L
V
DEAHGLGVRG-G-GR
G
L
L
Y
ELGLA-GAP
D
V
V
M
T
T
T
L
S
K
A
L-GSQG
G
V
V
LGPT
P
V
R
A
H
L
I
DAAR
P
F
I
FDTGL
A
P
A
A
V
G
A
A
R
A
A
L
R
V
L
--QAEP------W--R
P
Q
-----
A
V
L
N
H
A
----
G
E
L
A
R
----
M
---CGV-----AA------VP----D------S
A
M
V
S
V
I
LGEP
E
S
A
V
A
A
A
A
A
C
L
-DAG
V
K
VGCFRPPTVPAGT
S
R
L
R
L
T
A
RASLN
A
G
E
L
E
L
A
R
R
V
L
T
D
V
L
A
V
ARR
1
PsiBlast_PDB
97.29
76%
-111
- C1 -
3WY7
-
BIOF_MYCS2
A:
[37-381]
------------------------------------------
E
L
D
L
A
S
N
D
Y
L
G
L
S
Q
H
P
D
V
L
D
G
G
V
E
A
L
R
T
W
G
G
G
A
G
G
S
R
L
V
T
G
N
T
E
L
H
E
A
F
E
H
Q
L
A
S
F
L
G
A
E
S
A
L
V
F
S
S
G
Y
T
A
N
L
G
A
L
V
A
L
S
--
G
P
G
S
L
I
V
S
D
A
L
S
H
A
S
L
V
D
A
C
R
L
S
R
A
R
V
V
V
S
P
H
R
D
V
D
A
V
D
A
A
L
-
A
A
R
T
-
E
E
R
A
---
V
V
V
T
E
S
V
F
S
A
D
G
D
L
A
P
L
R
D
L
H
A
V
C
R
R
H
G
A
L
L
L
V
D
E
A
H
G
L
G
V
R
G
-
T
R
G
Q
G
L
L
H
E
V
G
L
A
-
G
A
P
D
I
V
M
T
T
T
L
S
K
A
L
-
G
S
Q
G
G
A
V
L
G
P
E
A
V
R
A
H
L
I
D
T
A
R
S
F
I
F
D
T
G
L
A
P
A
A
V
G
A
A
S
A
A
L
R
V
L
--
D
A
E
P
------
Q
--
R
A
R
-----
A
V
L
D
R
A
----
A
E
L
A
T
----
I
---
A
G
V
-----
T
E
------
A
P
----
V
------
S
A
V
V
S
V
I
L
G
D
P
E
I
A
V
G
A
A
A
A
C
L
-
D
R
G
V
R
V
G
C
F
R
P
P
T
V
P
A
G
T
S
R
L
R
L
A
A
R
A
S
L
T
D
D
E
M
A
L
A
R
Q
V
L
T
D
V
L
A
T
A
R
-
69
HHSearch
96.12
76%
-110
- C1 -
3WY7
-
BIOF_MYCS2
A:
[37-381]
------------------------------------------
E
L
D
L
A
S
N
D
Y
L
G
L
S
Q
H
P
D
V
L
D
G
G
V
E
A
L
R
T
W
G
G
G
A
G
G
S
R
L
V
T
G
N
T
E
L
H
E
A
F
E
H
Q
L
A
S
F
L
G
A
E
S
A
L
V
F
S
S
G
Y
T
A
N
L
G
A
L
V
A
L
S
--
G
P
G
S
L
I
V
S
D
A
L
S
H
A
S
L
V
D
A
C
R
L
S
R
A
R
V
V
V
S
P
H
R
D
V
D
A
V
D
A
A
L
-
A
A
R
T
-
E
E
R
A
---
V
V
V
T
E
S
V
F
S
A
D
G
D
L
A
P
L
R
D
L
H
A
V
C
R
R
H
G
A
L
L
L
V
D
E
A
H
G
L
G
V
R
G
-
T
R
G
Q
G
L
L
H
E
V
G
L
A
-
G
A
P
D
I
V
M
T
T
T
L
S
K
A
L
-
G
S
Q
G
G
A
V
L
G
P
E
A
V
R
A
H
L
I
D
T
A
R
S
F
I
F
D
T
G
L
A
P
A
A
V
G
A
A
S
A
A
L
R
V
L
--
D
A
E
-----------
P
Q
-----
R
A
R
A
V
L
----
D
R
A
A
E
----
L
---
A
T
I
-----
A
G
VTE---
A
P
----
V
------
S
A
V
V
S
V
I
L
G
D
P
E
I
A
V
G
A
A
A
A
C
L
-
D
R
G
V
R
V
G
C
F
R
P
P
T
V
P
A
G
T
S
R
L
R
L
A
A
R
A
S
L
T
D
D
E
M
A
L
A
R
Q
V
L
T
D
V
L
A
T
A
R
-
75
HHSearch
78.35
31%
-101
- C1 -
2BWN
4
HEM1_RHOCB
A:
[45-397]
---------------------------------------
K
Q
D
I
T
V
W
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
-
A
A
D
D
P
A
A
P
K
---
L
I
A
F
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
-
P
R
G
A
G
V
A
E
R
D
G
L
M
-
H
R
I
D
-
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
E
G
Q
----
K
--
L
R
D
-----
A
Q
Q
M
H
A
----
K
V
L
K
M
----
R
---
L
K
A
-----
L
G
MPII--
D
H
----
G
------
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
-----
14
PsiBlast_PDB
77.52
35%
-96
- C1 -
1BS0
2
BIOF_ECOLI
A:
[42-380]
-------------------------------------------
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
-
A
S
P
C
-
P
G
Q
Q
---
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
-
G
R
G
S
C
W
---
L
Q
-
K
V
K
P
E
L
L
V
V
T
F
G
K
G
F
-
G
V
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
E
------
G
D
A
R
R
E
-----
K
L
---
A
----
A
L
I
T
R
----
F
R
--
A
G
V
-----
Q
D
------
L
P
----
F
T
L
A
DSC
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
---------
15
PsiBlast_PDB
76.90
35%
-96
- C1 -
2G6W
1
BIOF_ECOLI
A:
[42-380]
-------------------------------------------
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
-
A
S
P
C
-
P
G
Q
Q
---
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
-
G
R
G
S
C
W
---
L
Q
-
K
V
K
P
E
L
L
V
V
T
F
G
K
G
F
-
G
V
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
E
------
G
D
A
R
R
E
-----
K
L
---
A
----
A
L
I
T
R
----
F
R
--
A
G
V
-----
Q
D
------
L
P
----
F
T
L
A
DSC
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
---------
71
HHSearch
76.83
25%
-97
- C1 -
3KKI
5
CQSA_VIBCH
A:
[58-404]
---------------------------------------
S
P
D
D
I
I
L
Q
S
N
D
Y
L
A
L
A
N
H
P
L
I
K
A
R
L
A
K
S
L
L
E
E
Q
Q
S
L
F
M
S
A
S
F
L
Q
N
D
Y
D
K
P
M
I
E
K
R
L
A
K
F
T
G
F
D
E
C
L
L
S
Q
S
G
W
N
A
N
V
G
L
L
Q
T
I
C
--
Q
P
N
T
N
V
Y
I
D
F
F
A
H
M
S
L
W
E
G
A
R
Y
A
N
A
Q
A
H
P
F
M
H
N
N
C
D
H
L
R
M
L
I
-
Q
R
H
---
G
P
G
---
I
I
V
V
D
S
I
Y
S
T
L
G
T
I
A
P
L
A
E
L
V
N
I
S
K
E
F
G
C
A
L
L
V
D
E
S
H
S
L
G
T
H
G
-
P
N
G
A
G
L
L
A
E
L
G
L
T
-
R
E
V
H
-
F
M
T
A
S
L
A
K
T
F
-
A
Y
R
A
G
A
I
W
C
N
N
E
V
N
R
C
V
P
F
I
S
Y
P
A
I
F
S
S
T
L
L
P
Y
E
A
A
G
L
E
T
T
L
E
I
I
--
E
S
A
D
------
N
--
R
R
Q
-----
H
L
D
R
M
A
----
R
K
L
R
I
----
G
---
L
S
Q
-----
L
G
LTI---
R
S
----
E
------
S
Q
I
I
G
L
E
T
G
D
E
R
N
T
E
K
V
R
D
Y
L
E
-
S
N
G
V
F
G
S
V
F
C
R
P
A
T
S
K
N
K
N
I
I
R
L
S
L
N
S
D
V
N
D
E
Q
I
A
K
I
I
E
V
C
S
D
A
V
N
Y
G
--
17
PsiBlast_PDB
76.59
35%
-99
- C1 -
1DJE
3
BIOF_ECOLI
A:
[42-380]
-------------------------------------------
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
-
A
S
P
C
-
P
G
Q
Q
---
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
-
G
R
G
S
C
W
---
L
Q
-
K
V
K
P
E
L
L
V
V
T
F
G
K
G
F
-
G
V
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
E
------
G
D
A
R
R
E
-----
K
L
---
A
----
A
L
I
T
R
----
F
R
--
A
G
V
-----
Q
D
------
L
P
----
F
T
L
A
DSC
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
---------
77
HHSearch
75.86
35%
-94
- C1 -
1BS0
2
BIOF_ECOLI
A:
[37-383]
--------------------------------------
D
D
R
Q
Y
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
-
A
S
P
C
-
P
G
Q
Q
---
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
-
E
Q
G
R
G
S
C
W
L
Q
--
K
-
V
K
P
E
-
L
L
V
V
T
F
G
K
G
F
-
G
V
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
E
G
D
----
A
--
R
R
E
-----
K
L
A
A
L
I
----
T
R
F
R
A
----
G
---
V
Q
D
-----
L
P
F
T
L
A
--
D
S
----
C
------
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
------
72
HHSearch
75.76
34%
-99
- C1 -
2W8T
-
?
A:
[65-417]
----------------------------------------
K
D
T
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
C
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
-
G
R
L
P
K
E
P
A
K
---
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
-
P
N
G
R
G
V
Y
E
A
Q
G
L
E
-
G
Q
I
D
-
F
V
V
G
T
F
S
K
S
V
-
G
T
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
H
------
E
--
K
R
E
-----
R
L
W
S
N
A
----
R
A
L
H
G
----
G
---
L
K
A
-----
M
G
F
R
L
GTE
T
C
----
D
------
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
-
90
Fugue
75.19
32%
-92
- C1 -
1BS0
3
BIOF_ECOLI
A:
[2-384]
S
W
Q
E
K
I
N
A
A
L
D
A
R
R
A
A
D
A
L
R
R
R
Y
P
V
A
Q
G
A
G
R
W
L
V
A
D
D
---
R
Q
Y
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
-
A
S
P
C
-
P
G
Q
Q
---
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
-
G
R
G
S
C
W
L
Q
K
V
K
---
P
E
L
L
V
V
T
-
F
G
K
G
F
-
G
V
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
R
S
D
E
G
D
------
A
--
R
R
E
-----
K
L
A
A
L
I
----
T
R
F
R
A
----
G
---
V
Q
D
-----
L
P
------
F
T
L
A
DS
C
------
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
-----
74
HHSearch
74.64
30%
-97
* C1 *
3A2B
2
?
A:
[42-392]
---------------------------------------
G
R
R
V
L
M
F
G
S
N
S
Y
L
G
L
T
T
D
T
R
I
I
K
A
A
Q
D
A
L
E
K
Y
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
E
L
E
E
K
L
S
A
Y
V
G
K
E
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
L
M
--
G
R
N
D
Y
I
L
L
D
E
R
D
H
A
S
I
I
D
G
S
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
R
A
K
L
-
S
R
L
P
E
D
S
A
K
---
L
I
C
T
D
G
I
F
S
M
E
G
D
I
V
N
L
P
E
L
T
S
I
A
N
E
F
D
A
A
V
M
V
D
D
A
H
S
L
G
V
I
G
-
H
K
G
A
G
T
A
S
H
F
G
L
N
-
D
D
V
D
-
L
I
M
G
T
F
S
K
S
L
-
A
S
L
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
S
T
L
K
A
L
E
I
I
--
Q
N
E
P
------
E
--
H
I
E
-----
K
L
W
K
N
T
----
D
Y
A
K
A
----
Q
---
L
L
D
-----
H
G
FDLG--
A
T
----
E
------
S
P
I
L
P
I
F
I
R
S
N
E
K
T
F
W
V
T
K
M
L
Q
-
D
D
G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
M
A
T
H
T
Y
D
Q
I
D
E
A
I
E
K
M
V
K
V
F
K
Q
A
--
16
PsiBlast_PDB
74.45
35%
-98
- C1 -
1DJ9
3
BIOF_ECOLI
A:
[42-380]
-------------------------------------------
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
--
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
-
A
S
P
C
-
P
G
Q
Q
---
M
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
-
G
R
G
S
C
W
---
L
Q
-
K
V
K
P
E
L
L
V
V
T
F
G
K
G
F
-
G
V
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
E
------
G
D
A
R
R
E
-----
K
L
---
A
----
A
L
I
T
R
----
F
R
--
A
G
V
-----
Q
D
------
L
P
----
F
TLADSC
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
-
Q
Q
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
---------
7
PsiBlast_PDB
74.43
36%
-100
- C1 -
2W8U
-
?
A:
[70-403]
---------------------------------------------
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
Y
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
-
E
P
A
K
---
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
-
G
R
G
V
Y
E
A
Q
G
L
E
-
G
Q
I
D
F
V
V
-
G
T
F
S
K
S
V
-
G
T
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
H
------
E
--
K
R
E
-----
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
----
M
GFR
L
G
T
-----
E
T
------
C
-----
D
------
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
---------------
70
HHSearch
74.35
27%
-102
- C1 -
4IW7
-
?
A:
[26-371]
---------------------------------------
D
D
S
I
I
D
F
T
T
S
D
Y
L
N
L
S
S
A
H
N
L
K
H
A
I
V
N
G
F
D
K
Y
G
F
G
S
K
--------
T
D
E
T
Q
Q
F
E
H
E
F
A
K
F
I
N
Y
P
R
A
I
F
F
S
S
G
F
M
A
N
L
A
I
Y
S
T
L
F
--
S
K
H
D
S
I
F
A
D
K
Y
I
H
A
S
I
I
D
G
I
K
L
S
Q
A
K
L
R
R
Y
K
H
Q
Q
L
S
Q
L
Q
D
I
Y
-
D
-----
G
K
S
---
F
I
T
T
E
G
V
F
S
T
S
G
S
I
T
Q
L
D
K
L
A
K
I
T
---
P
E
K
L
I
V
D
E
A
H
S
F
G
V
L
G
-
K
N
G
R
G
A
I
N
S
F
R
I
S
Y
K
N
C
L
-
I
C
V
F
P
L
G
K
A
F
-
G
G
V
G
A
V
V
C
T
T
E
A
I
A
E
Y
L
I
Q
F
A
R
N
Y
I
Y
T
T
A
L
P
P
M
I
L
K
A
A
L
I
Q
L
K
N
L
--
E
N
V
N
------
D
--
N
R
A
-----
R
L
Q
Q
N
I
----
T
F
F
N
E
----
L
---
C
D
A
K
DLEL
V
S
------
K
D
----
L
------
S
P
I
R
S
I
Q
L
N
N
A
N
L
A
I
R
L
K
D
K
L
F
-
E
N
K
I
I
V
S
-
F
R
Y
P
T
----
Q
A
I
L
R
F
S
L
H
S
N
N
T
F
D
Q
I
Q
Q
A
L
E
I
I
S
K
E
V
K
Y
E
Y
-
12
PsiBlast_PDB
73.56
30%
-101
- C1 -
3A2B
2
?
A:
[46-392]
-------------------------------------------
L
M
F
G
S
N
S
Y
L
G
L
T
T
D
T
R
I
I
K
A
A
Q
D
A
L
E
K
Y
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
E
L
E
E
K
L
S
A
Y
V
G
K
E
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
L
M
--
G
R
N
D
Y
I
L
L
D
E
R
D
H
A
S
I
I
D
G
S
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
R
A
K
L
-
S
R
L
P
-
E
D
S
A
K
--
L
I
C
T
D
G
I
F
S
M
E
G
D
I
V
N
L
P
E
L
T
S
I
A
N
E
F
D
A
A
V
M
V
D
D
A
H
S
L
G
V
I
G
H
K
-
G
A
G
T
A
S
H
F
G
L
N
-
D
D
V
D
L
I
M
-
G
T
F
S
K
S
L
-
A
S
L
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
S
T
L
K
A
L
E
I
I
--
Q
N
E
P
E
H
I
E
K
L
W
--
K
N
T
D
Y
A
K
A
Q
L
L
D
H
G
----
F
D
L
-------------------
G
------
A
T
----
E
------
S
P
I
L
P
I
F
I
R
S
N
E
K
T
F
W
V
T
K
M
L
Q
-
D
D
G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
M
A
T
H
T
Y
D
Q
I
D
E
A
I
E
K
M
V
K
V
F
K
Q
A
--
9
PsiBlast_PDB
73.50
36%
-99
- C1 -
2W8V
-
?
A:
[70-403]
---------------------------------------------
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
W
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
-
E
P
A
K
---
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
-
G
R
G
V
Y
E
A
Q
G
L
E
-
G
Q
I
D
F
V
V
-
G
T
F
S
K
S
V
-
G
T
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
H
------
E
--
K
R
E
-----
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
----
M
GFR
L
G
T
-----
E
T
------
C
-----
D
------
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
---------------
5
PsiBlast_PDB
73.38
36%
-99
- C1 -
2XBN
1
?
A:
[69-402]
---------------------------------------------
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
-
E
P
A
K
---
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
-
G
R
G
V
Y
E
A
Q
G
L
E
-
G
Q
I
D
F
V
V
-
G
T
F
S
K
S
V
-
G
T
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
H
------
E
--
K
R
E
-----
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
----
M
GFR
L
G
T
-----
E
T
------
C
-----
D
------
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
---------------
4
PsiBlast_PDB
73.30
36%
-99
- C1 -
2W8J
1
?
A:
[69-402]
---------------------------------------------
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
-
E
P
A
K
---
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
-
G
R
G
V
Y
E
A
Q
G
L
E
-
G
Q
I
D
F
V
V
-
G
T
F
S
K
S
V
-
G
T
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
H
------
E
--
K
R
E
-----
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
----
M
GFR
L
G
T
-----
E
T
------
C
-----
D
------
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
---------------
2
PsiBlast_PDB
72.80
36%
-98
- C1 -
2JG2
-
?
A:
[70-403]
---------------------------------------------
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
-
E
P
A
K
---
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
-
G
R
G
V
Y
E
A
Q
G
L
E
-
G
Q
I
D
F
V
V
-
G
T
F
S
K
S
V
-
G
T
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
H
------
E
--
K
R
E
-----
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
----
M
GFR
L
G
T
-----
E
T
------
C
-----
D
------
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
---------------
8
PsiBlast_PDB
72.63
36%
-98
- C1 -
2W8T
-
?
A:
[70-403]
---------------------------------------------
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
C
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
-
E
P
A
K
---
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
-
G
R
G
V
Y
E
A
Q
G
L
E
-
G
Q
I
D
F
V
V
-
G
T
F
S
K
S
V
-
G
T
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
H
------
E
--
K
R
E
-----
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
----
M
G
F
R
L
G
T
-----
E
T
------
C
-----
D
------
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
---------------
6
PsiBlast_PDB
71.87
36%
-96
- C1 -
2W8W
1
?
A:
[69-402]
---------------------------------------------
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
Y
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
-
E
P
A
K
---
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
-
G
R
G
V
Y
E
A
Q
G
L
E
-
G
Q
I
D
F
V
V
-
G
T
F
S
K
S
V
-
G
T
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
H
------
E
--
K
R
E
-----
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
----
M
GFR
L
G
T
-----
E
T
------
C
-----
D
------
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
---------------
10
PsiBlast_PDB
71.08
36%
-95
- C1 -
4BMK
6
?
A:
[91-424]
---------------------------------------------
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
-
E
P
A
K
---
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
-
G
R
G
V
Y
E
A
Q
G
L
E
-
G
Q
I
D
F
V
V
-
G
T
F
S
A
S
V
-
G
T
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
H
------
E
--
K
R
E
-----
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
----
M
G
F
R
L
G
T
-----
E
T
------
C
-----
D
------
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
---------------
13
PsiBlast_PDB
70.36
31%
-91
- C1 -
3TQX
2
?
A:
[46-385]
-------------------------------------------
L
N
F
C
A
N
N
Y
L
G
L
A
D
H
P
A
L
I
K
T
A
Q
T
V
V
E
Q
Y
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
T
I
H
K
E
L
E
K
D
I
S
E
F
L
G
T
D
D
T
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
--
G
P
E
D
A
I
I
S
D
E
L
N
H
A
S
I
I
D
G
I
R
L
C
K
A
Q
R
Y
R
Y
K
N
N
A
M
G
D
L
E
A
K
L
-
K
E
A
D
-
E
K
G
A
R
F
K
L
I
A
T
D
G
V
F
S
M
D
G
I
I
A
D
L
K
S
I
C
D
L
A
D
K
Y
N
A
L
V
M
V
D
D
S
H
A
V
G
F
I
G
E
N
-
G
R
G
T
P
E
Y
C
G
V
A
-
D
R
V
D
-
I
L
T
G
T
L
G
K
A
L
G
G
A
S
G
G
Y
T
S
G
H
K
E
I
I
E
W
L
R
N
R
S
R
P
Y
L
F
S
N
T
V
A
P
V
I
V
A
T
S
L
K
V
L
E
L
L
--
K
T
E
G
------
P
--
Q
L
R
-----
K
Q
L
Q
E
N
----
S
R
Y
F
R
A
G
M
E
K
---
L
G
F
-----
Q
L
------
V
P
G---
N
------
H
P
I
I
P
V
M
L
G
D
A
Q
L
A
T
N
M
A
D
H
L
L
-
Q
E
G
I
Y
V
V
G
F
S
Y
P
V
V
P
M
G
K
A
R
I
R
V
Q
M
S
A
V
H
T
Q
Q
Q
L
D
R
A
-------------
21
PsiBlast_CBE
70.00
36%
-101
- C1 -
4BMK
4
?
B:
[91-424]
---------------------------------------------
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
--
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
K
-
E
P
A
K
---
L
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
-
G
R
G
V
Y
E
A
Q
G
L
E
-
G
Q
I
D
F
V
V
-
G
T
F
S
A
S
V
-
G
T
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
H
------
E
--
K
R
E
-----
R
L
W
S
N
A
RALH
G
G
L
K
A
----
M
GFR
L
G
T
-----
E
T
------
C
-----
D
------
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
-
D
G
G
L
Y
V
N
M
A
----------
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
---------------