@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1595: (2016-05-03 )
MAGPAWRDAADVVVIGTGVAGLAAALAADRAGRSVVVLSKAAQTHVTATHYAQGGIAVVLPDNDDSVDAHVADTLAAGAGLCDPDAVYSIVADGYRAVTDLVGAGARLDESVPGRWALTREGGHSRRRIVHAGGDATGAEVQRALQDAAGMLDIRTGHVALRVLHDGTAVTGLLVVRPDGCGIISAPSVILATGGLGHLYSATTNPAGSTGDGIALGLWAGVAVSDLEFIQFHPTMLFAGRAGGRRPLITEAIRGEGAILVDRQGNSITAGVHPMGDLAPRDVVAAAIDARLKATGDPCVYLDARGIEGFASRFPTVTASCRAAGIDPVRQPIPVVPGAHYSCGGIVTDVYGQTELLGLYAAGEVARTGLHGANRLASNSLLEGLVVGGRAGKAAAAHAAAAGRSRATSSATWPEPISYTALDRGDLQRAMSRDASMYRAAAGLHRLCDSLSGAQVRDVACRRDFEDVALTLVAQSVTAAALARTESRGCHHRAEYPCTVPEQARSIVVRGADDANAVCVQALVAVC
Atome Classification :
(46 SA)
.........10........20.....-...30--..--......40--...--.....50........60-.-.......70........80........90........100...---....110...----....120...-------....130..---------...----------..140...--....---150--.--...--....160....-.-------.-.---------170.--.-..--..-.180.---------------------..-....190.......200.......210.......220.......230.......240.......250.......260.......270-----....------------.-------..280.....-----..290..-------..------...---------300..--.--..--.--.310.......320.-.-.-.....330.......340.......--------350.----------....----------..360.......370.......380......-------.390.......400..-------..-.-----..---410----.---...--.....------------420.--------------..-------....430.......----440--........---.450.....-------------..460.----------.-----..-------..--------------.------470-------.......480-------.......490...--.--...500-.......-510.......520.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGPAWRDAA
D
V
V
V
I
GT
G
V
A
G
L
A
A
A
L
-
A
ADRA--G
R
--
S
V
V
V
L
SKA--AQ
T
--
H
V
T
A
T
HYAQG
G
I
A
V
V
LP-D-NDDS
V
D
A
H
V
A
D
T
L
AAGAGLC
D
P
D
A
V
Y
S
I
V
A
D
G
Y
R
A
V
T
D
L
V
GAG---ARLDESVPG
R
----
W
A
L
TREGGHS-------R
R
R
I
V
HAGG---------DA
T
----------
G
A
E
V
Q
R
A
L
--
Q
DAA---G
M
---
L
--
D
I
R--TG
H
V
A
L
R
V
LHD-G-------T-
A
---------
V
T
G
L
--
L
-
V
V--RP-DGCGI---------------------IS-AP
S
V
I
L
ATGGLG
H
L
YSATTNPAGSTGD
G
I
A
L
G
L
WAG
V
A
V
S
D
L
E
F
I
Q
FHP
T
M
L
F
AGRAGGRRP
L
I
T
E
AIRGE
G
A
I
L
V
DRQGN
S
I
TAGV-----HPMG------------D-------L
A
P
R
D
V
V
A
A
A
-----
I
D
A
R
LKA-------TG------D
P
C
---------
V
Y
L
DA--R--GI--
E
--
G
F
A
S
RFPTVTASC-R-A-A-GIDPVRQPIPVVPGAHYSCG
G
I
V
TD--------VYGQ----------
T
E
L
L
----------
G
L
YAA
G
E
V
A
R
T
GLH
G
A
N
R
L
A
S
N
S
L
L
E
G
LVVG-------GRAGK
A
A
A
A
H
AAAAGR-------SR-A-----TS---S------A---TWP--EPI
S
Y
------------TAL
D
--------------
R
G
-------
D
L
Q
R
A
M
S
R
D
A
S
M
Y
R
----
A
----
A
A
G
L
H
R
L
C
---
D
SLSGA
Q
V
R
-------------
D
V
A
C
RR----------
D
-----
F
E
-------
D
V
--------------
A
------
L
T
L
-------
V
A
Q
S
V
T
A
A
A
L
-------
A
RTESRGCHHRAE--Y--PCTV
P
E
-
Q
A
R
S
I
V
V
-RGAD
D
A
N
A
V
C
V
Q
A
L
V
AVC
2
PsiBlast_PDB
80.48
37%
-78
- C2 -
1KNP
3
NADB_ECOLI
A:
[8-533]
--------
S
C
D
V
L
I
I
G
S
G
A
A
G
L
S
L
A
L
R
L
A
D
Q
----
H
--
Q
V
I
V
L
S
K
G
--
P
V
T
--
E
-
G
S
T
F
Y
A
Q
G
G
I
A
A
V
F
--
D
-
E
T
D
S
I
D
S
H
V
E
D
T
L
I
A
G
A
G
I
C
D
R
H
A
V
E
F
V
A
S
N
A
R
S
C
V
Q
W
L
I
D
Q
G
---
V
L
F
D
T
H
I
Q
P
N
G
E
E
S
Y
H
L
T
R
E
G
G
H
S
-------
H
R
R
I
L
H
A
A
----------
D
A
T
----------
G
R
E
V
E
T
T
L
--
V
S
K
A
----------------
L
N
H
P
N
I
R
V
L
E
R
-
T
-------
N
-
A
---------
V
D
------
L
I
--
V
S
-
D
K
I
G
L
PGTRRVV
G
A
W
V
WNRNKE
T
V
E
T
C
H
-
A
K
A
V
V
L
A
T
G
G
A
S
K
V
Y
Q
Y
T
T
N
P
D
I
S
S
G
D
G
I
A
M
A
W
R
A
G
C
R
V
A
N
L
E
F
N
Q
F
H
P
T
A
L
Y
H
P
Q
A
--
R
N
F
L
L
T
E
A
L
R
G
E
G
A
Y
L
K
R
P
D
G
T
R
F
M
P
D
F
-----
D
E
R
G
------------
E
-------
L
A
P
R
D
I
V
A
R
A
-----
I
D
H
E
M
K
R
-------
L
G
------
A
D
C
---------
M
F
L
D
I
SH
K
--
P
A
--
D
--
F
I
R
Q
H
F
P
M
I
Y
E
K
L
-
L
-
G
-
L
-
G
I
D
L
T
Q
E
P
V
P
I
V
P
A
A
H
Y
T
C
G
G
V
M
V
D
--------
D
H
G
R
----------
T
D
V
E
----------
G
L
Y
A
I
G
E
V
S
Y
T
G
L
H
G
A
N
L
M
A
S
N
S
L
L
E
C
L
V
Y
G
-------
W
S
A
A
E
D
I
T
R
R
M
P
Y
A
---------
H
D
-
I
-----
S
T
---
L
------
P
---
P
W
D
--
E
S
R
V
E
------------
N
P
D
E
--------------
R
V
-------
V
I
Q
H
N
W
H
E
L
R
L
F
M
W
----
D
----
Y
V
G
I
V
R
T
T
---
K
R
L
E
R
A
L
R
R
-------------
I
T
M
L
Q
Q
----------
E
-----
I
D
-------
E
Y
YAHFRVS
N
N
L
L
E
L
R
N
------
L
V
Q
-------
V
A
E
L
I
V
R
C
A
M
-------
M
R
K
E
S
R
G
L
H
F
T
L
D
--
Y
--
P
E
L
L
T
H
-
S
G
P
S
I
L
S
-
P
-----------------
86
PsiBlast_CBE
80.47
31%
-80
- C2 -
3VR9
2
?
A:
[41-593]
--------
A
Y
D
V
V
I
I
G
A
G
G
A
G
L
R
A
A
M
-
G
L
G
E
A
--
G
F
--
K
T
A
V
V
T
K
M
--
F
P
T
RS
H
T
T
A
---
A
Q
G
G
I
N
A
A
L
G
-
S
M
N
P
D
D
W
K
W
H
F
Y
D
T
A
K
G
S
D
W
L
G
D
Q
N
A
M
H
Y
L
T
R
N
A
V
E
A
V
T
E
L
E
N
F
G
---
M
P
F
S
R
T
P
E
G
K
----
I
Y
Q
R
S
F
G
G
Q
S
-------
N
N
--
Y
G
K
G
G
VAKRTCCVA
D
R
T
----------
G
H
S
M
L
H
T
L
Y
G
N
S
L
R
---
C
H
---
C
--
T
F
F
--
I
E
Y
F
A
L
D
L
L
M
D
-
K
-------
G
-
R
---------
C
V
G
V
--
I
-
A
L
--
C
L
-
E
D
G
T
I
H
R
-------------------
F
R
-
S
K
R
T
I
V
A
T
G
G
Y
G
R
A
Y
F
S
C
T
T
A
H
M
N
T
G
D
G
T
A
L
A
T
R
A
G
I
A
L
E
D
L
E
F
I
Q
F
H
P
T
G
I
Y
-----
G
V
G
C
L
I
T
E
G
S
R
G
E
G
G
F
L
V
N
S
E
G
E
R
F
M
E
R
Y
-----
A
P
K
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
A
E
T
I
E
I
M
E
G
R
G
V
G
-------
P
E
------
K
D
H
---------
I
Y
L
Q
L
--
H
--
H
L
P
A
E
--
Q
L
H
Q
R
L
P
G
I
S
E
T
A
-
K
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
I
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
A
Q
V
I
K
Y
T
KEGGD
K
I
V
P
----------
G
L
Y
A
C
G
E
C
A
C
H
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
A
V
V
F
G
-------
R
A
C
S
I
N
I
K
E
E
L
K
P
D
E
K
-------
I
P
-
E
-----
L
P
---
E
------
G
---
A
G
E
--
E
S
I
A
N
L
D
A
V
R
Y
A
N
G
DVP
T
A
E
L
--------------
R
L
-------
T
M
Q
K
T
M
Q
K
H
A
G
V
F
R
R
G
D
I
L
----
A
E
G
V
K
K
M
M
---
D
-
L
S
K
E
L
K
R
-------------
L
K
T
T
D
R
SLIWN
S
D
L
T
E
S
-----
L
E
-------
L
Q
--------------
N
------
L
M
L
-------
N
A
T
Q
T
I
V
A
A
E
-------
N
R
K
E
S
R
G
A
H
A
R
D
D
--
F
--
P
K
R
E
D
E
-
Y
D
Y
S
K
P
I
-
E
G
----------------
88
PsiBlast_CBE
80.43
31%
-80
- C2 -
3VR8
2
?
A:
[41-593]
--------
A
Y
D
V
V
I
I
G
A
G
G
A
G
L
R
A
A
M
-
G
L
G
E
A
--
G
F
--
K
T
A
V
V
T
K
M
--
F
P
T
RS
H
T
T
A
---
A
Q
G
G
I
N
A
A
L
G
-
S
M
N
P
D
D
W
K
W
H
F
Y
D
T
A
K
G
S
D
W
L
G
D
Q
N
A
M
H
Y
L
T
R
N
A
V
E
A
V
T
E
L
E
N
F
G
---
M
P
F
S
R
T
P
E
G
K
----
I
Y
Q
R
S
F
G
G
Q
S
-------
N
N
--
Y
G
K
G
G
VAKRTCCVA
D
R
T
----------
G
H
S
M
L
H
T
L
Y
G
N
S
L
R
---
C
H
---
C
--
T
F
F
--
I
E
Y
F
A
L
D
L
L
M
D
-
K
-------
G
-
R
---------
C
V
G
V
--
I
-
A
L
--
C
L
-
E
D
G
T
I
H
R
-------------------
F
R
-
S
K
R
T
I
V
A
T
G
G
Y
G
R
A
Y
F
S
C
T
T
A
H
M
N
T
G
D
G
T
A
L
A
T
R
A
G
I
A
L
E
D
L
E
F
I
Q
F
H
P
T
G
I
Y
-----
G
V
G
C
L
I
T
E
G
S
R
G
E
G
G
F
L
V
N
S
E
G
E
R
F
M
E
R
Y
-----
A
P
K
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
A
E
T
I
E
I
M
E
G
R
G
V
G
-------
P
E
------
K
D
H
---------
I
Y
L
Q
L
--
H
--
H
L
P
A
E
--
Q
L
H
Q
R
L
P
G
I
S
E
T
A
-
K
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
I
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
A
Q
V
I
K
Y
T
KEG
G
D
K
I
V
P
----------
G
L
Y
A
C
G
E
C
A
C
H
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
A
V
V
F
G
-------
R
A
C
S
I
N
I
K
E
E
L
K
P
D
E
K
-------
I
P
-
E
-----
L
P
---
E
------
G
---
A
G
E
--
E
S
I
A
N
L
D
A
V
R
Y
ANGDVP
T
A
E
L
--------------
R
L
-------
T
M
Q
K
T
M
Q
K
H
A
G
V
F
R
R
G
D
I
L
----
A
E
G
V
K
K
M
M
---
D
-
L
S
K
E
L
K
R
-------------
L
K
T
T
D
R
SLIWN
S
D
L
T
E
S
-----
L
E
-------
L
Q
--------------
N
------
L
M
L
-------
N
A
T
Q
T
I
V
A
A
E
-------
N
R
K
E
S
R
G
A
H
A
R
D
D
--
F
--
P
K
R
E
D
E
-
Y
D
Y
S
K
P
I
-
E
G
----------------
112
HHSearch
80.03
34%
-83
- C2 -
1KF6
5
FRDA_ECOLI
A:
[2-568]
-----
Q
T
F
Q
A
D
L
A
I
V
G
A
G
G
A
G
L
R
A
A
I
-
A
A
A
Q
A
NP
N
A
--
K
I
A
L
I
S
K
V
--
Y
P
---
M
R
S
H
T
V
A
A
E
G
G
S
A
A
V
A
Q
-
D
--
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
---
C
P
W
S
R
R
P
D
G
S
----
V
N
V
R
R
F
G
G
M
K
-------
I
E
R
T
W
F
A
-
A
---------
D
K
T
----------
G
F
H
M
L
H
T
L
--
F
Q
T
S
---
L
Q
F--
P
QI
Q
R
F
--
D
E
H
F
V
L
D
I
L
V
D
-
D
-------
G
-
H
---------
V
R
G
L
V
-
A
M
N
M
--
M
E
-
G
T
L
V
Q
---------------------
I
R
-
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
G
-----
I
L
M
T
E
G
C
R
G
E
G
G
I
L
V
N
K
N
G
Y
R
Y
L
Q
D
Y
-----
G
M
G
P
ETPLG
E
P
K
N
KYM
E
-------
L
G
P
R
D
K
V
S
Q
A
-----
F
W
H
E
W
R
K
-------
G
N
T
I
S
T
PR
G
D
V
---------
V
Y
L
D
L
--
R
--
H
L
--
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
K
A
-
Y
-
V
-
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
D
--------
Q
N
C
E
----------
T
R
I
K
----------
G
L
F
A
V
G
E
C
S
S
V
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
-------
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
G
N
-------
G
N
-
E
A
A
I
E
A
Q
A
---
A
G
V
E
Q
R
L
K
---
D
L
V
N
Q
D
G
G
E
N
------------
W
A
K
I
--------------
R
D
-------
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
----
T
----
P
E
L
M
Q
K
T
I
---
D
K
L
A
E
L
Q
E
R
F
K
R
VRITDTSSVF
N
T
D
L
L
Y
----------
T
-----
I
E
-------
L
G
--------------
H
------
G
L
N
-------
V
A
E
C
M
A
H
S
A
M
-------
A
R
K
E
S
R
G
A
H
Q
R
L
D
EG
C
--
T
E
R
D
D
V
N
F
L
K
H
T
L
A
F
R
D
A
D
G
T
T
R
L
E
Y
S
D
-----
3
PsiBlast_PDB
80.00
37%
-80
- C2 -
1KNR
3
NADB_ECOLI
A:
[8-533]
--------
S
C
D
V
L
I
I
G
S
G
A
A
G
L
S
L
A
L
R
L
A
D
Q
----
H
--
Q
V
I
V
L
S
K
G
--
P
V
T
--
E
-
G
S
T
F
Y
A
Q
G
G
I
A
A
V
F
--
D
-
E
T
D
S
I
D
S
H
V
E
D
T
L
I
A
G
A
G
I
C
D
R
H
A
V
E
F
V
A
S
N
A
R
S
C
V
Q
W
L
I
D
Q
G
---
V
L
F
D
T
H
I
Q
P
N
G
E
E
S
Y
H
L
T
R
E
G
G
H
S
-------
H
R
R
I
L
H
A
A
----------
D
A
T
----------
G
R
E
V
E
T
T
L
--
V
S
K
A
----------------
L
N
H
P
N
I
R
V
L
E
R
-
T
-------
N
-
A
---------
V
D
------
L
I
--
V
S
-
D
K
I
G
L
PGTRRVV
G
A
W
V
WNRNKE
T
V
E
T
C
H
-
A
K
A
V
V
L
A
T
G
G
A
S
K
V
Y
Q
Y
T
T
N
P
D
I
S
S
G
D
G
I
A
M
A
W
R
A
G
C
R
V
A
N
L
E
F
N
Q
F
H
P
T
A
L
Y
H
P
Q
A
--
R
N
F
L
L
T
E
A
L
R
G
E
G
A
Y
L
K
R
P
D
G
T
R
F
M
P
D
F
-----
D
E
R
G
------------
E
-------
L
A
P
R
D
I
V
A
R
A
-----
I
D
H
E
M
K
R
-------
L
G
------
A
D
C
---------
M
F
L
D
I
SH
K
--
P
A
--
D
--
F
I
R
Q
H
F
P
M
I
Y
E
K
L
-
L
-
G
-
L
-
G
I
D
L
T
Q
E
P
V
P
I
V
P
A
A
H
Y
T
C
G
G
V
M
V
D
--------
D
H
G
R
----------
T
D
V
E
----------
G
L
Y
A
I
G
E
V
S
Y
T
G
L
H
G
A
N
L
M
A
S
N
S
L
L
E
C
L
V
Y
G
-------
W
S
A
A
E
D
I
T
R
R
M
P
Y
A
---------
H
D
-
I
-----
S
T
---
L
------
P
---
P
W
D
--
E
S
R
V
E
------------
N
P
D
E
--------------
R
V
-------
V
I
Q
H
N
W
H
E
L
R
L
F
M
W
----
D
----
Y
V
G
I
V
R
T
T
---
K
R
L
E
R
A
L
R
R
-------------
I
T
M
L
Q
Q
----------
E
-----
I
D
-------
E
Y
YAHFRVS
N
N
L
L
E
L
R
N
------
L
V
Q
-------
V
A
E
L
I
V
R
C
A
M
-------
M
R
K
E
S
R
G
L
H
F
T
L
D
--
Y
--
P
E
L
L
T
H
-
S
G
P
S
I
L
S
-
P
-----------------
21
PsiBlast_CBE
79.84
31%
-94
- C2 -
2E5V
2
NADB_SULTO
B:
[2-469]
-----------
I
Y
I
I
G
S
G
I
A
G
L
S
A
G
V
-
A
L
R
R
A
--
G
K
--
K
V
T
L
I
S
K
R
--
I
D
G
----
G
S
T
P
I
A
K
G
G
V
A
A
S
V
G
---
S
D
D
S
P
E
L
H
A
Q
D
T
I
R
V
G
D
G
L
C
D
V
K
T
V
N
Y
V
T
S
E
A
K
N
V
I
E
T
F
E
S
W
G
---
F
E
F
E
E
D
----------
L
R
L
E
G
G
H
T
-------
K
R
R
V
L
H
R
T
----------
D
E
T
----------
G
R
E
I
F
N
F
L
--
L
K
L
A
REE
G
I
---
P
--
I
I
E
--
D
R
L
V
E
I
R
V
-
K
D
-
G
---------
K
---------
V
T
G
F
--
V
-
T
------
E
K
R
G
L
---------------------
V
E
D
V
D
K
L
V
L
A
T
G
G
Y
S
Y
L
Y
E
Y
S
S
T
Q
S
T
N
I
G
D
G
M
A
I
A
F
K
A
G
T
I
L
A
D
M
E
F
V
Q
F
H
P
T
V
T
---
S
L
D
G
E
V
F
L
L
T
E
T
L
R
G
E
G
A
Q
I
I
N
E
N
G
E
R
F
L
F
N
Y
-----
D
K
R
G
------------
E
-------
L
A
P
R
D
I
L
S
R
A
-----
I
--
Y
I
E
M
-------
L
K
------
G
H
K
---------
V
F
I
D
L
--
S
--
K
I
--
E
--
D
F
E
R
K
F
P
V
V
A
K
Y
L
-
A
-
R
-
H
-
G
H
N
-
Y
K
V
K
I
P
I
F
P
A
A
H
F
V
D
G
G
I
R
V
N
--------
I
R
G
E
----------
S
N
I
V
----------
N
L
Y
A
I
G
E
V
S
D
S
G
L
H
G
A
N
R
L
A
S
N
S
L
L
E
G
L
V
F
G
INLPRYV
D
S
S
W
E
G
I
S
T
D
D
G
I
V
H
S
-------
V
R
-
I
-----
S
G
---
N
------
K
---
T
-----------------------
L
S
--------------
L
K
-------
E
I
R
R
I
N
W
E
N
V
G
I
I
R
----
N
----
E
E
K
L
V
K
A
I
---
N
T
Y
S
S
S
T
Q
N
-------------
E
------------------------------------------------------
A
I
-------
I
S
Y
L
T
A
L
A
A
E
-------
I
R
K
E
S
R
G
N
H
F
R
E
D
--
Y
--
P
Y
K
D
P
N
-
W
E
K
R
I
Y
F
-
K
-----------------
81
PsiBlast_CBE
79.82
31%
-78
* C2 *
3VRB
2
?
E:
[41-593]
--------
A
Y
D
V
V
I
I
G
A
G
G
A
G
L
R
A
A
M
-
G
L
G
E
A
--
G
F
--
K
T
A
V
V
T
K
M
--
F
P
T
RS
H
T
T
A
---
A
Q
G
G
I
N
A
A
L
G
-
S
M
N
P
D
D
W
K
W
H
F
Y
D
T
A
K
G
S
D
W
L
G
D
Q
N
A
M
H
Y
L
T
R
N
A
V
E
A
V
T
E
L
E
N
F
G
---
M
P
F
S
R
T
P
E
G
K
----
I
Y
Q
R
S
F
G
G
Q
S
-------
N
N
--
Y
G
K
G
G
VAKRTCCVA
D
R
T
----------
G
H
S
M
L
H
T
L
YG
N
S
L
R
---
C
H
---
C
--
T
F
F
--
I
E
Y
F
A
L
D
L
L
M
D
-
K
-------
G
-
R
---------
C
V
G
V
--
I
-
A
L
--
C
L
-
E
D
G
T
I
HR-------------------
F
R
-
S
K
R
T
I
V
A
T
G
G
Y
G
R
A
Y
F
S
C
T
T
A
H
M
N
T
G
D
G
T
A
L
A
T
R
A
G
I
A
L
E
D
L
E
F
I
Q
F
H
P
T
G
I
Y
-----
G
V
G
C
L
I
T
E
G
S
R
G
E
G
G
F
L
V
N
S
E
G
E
R
F
M
E
R
Y
-----
A
P
K
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
A
ETIEI
M
E
G
R
G
V
G
-------
P
E
------
K
D
H
---------
I
Y
L
Q
L
--
H
--
H
L
PA
E
--
Q
L
H
Q
R
L
P
G
I
S
E
T
A
-
K
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
I
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
A
Q
VIKYTKEGGD
K
I
V
P
----------
G
L
Y
A
C
G
E
C
A
C
H
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
A
V
V
F
G
-------
R
A
C
S
I
N
I
K
E
E
L
K
P
D
E
K
-------
I
P
-
E
-----
L
P
---
E
------
G
---
A
G
E
--
E
S
I
A
N
LDAVRYANGDVP
T
A
E
L
--------------
R
L
-------
T
M
Q
K
T
M
Q
K
H
A
G
V
F
R
RGDI
L
----
A
E
G
V
K
K
M
M
---
D
-
L
S
K
E
L
K
R
-------------
L
K
T
T
D
R
SLIWNSDLTE
S
-----
L
E
-------
L
Q
--------------
N
------
L
M
L
-------
N
A
T
Q
T
I
V
A
A
E
-------
N
R
K
E
S
R
G
A
H
A
R
D
D
--
F
--
P
K
R
E
D
E
-
Y
D
Y
S
K
P
I
-
E
G
----------------
87
PsiBlast_CBE
79.43
31%
-74
- C2 -
3VR8
2
?
E:
[41-593]
--------
A
Y
D
V
V
I
I
G
A
G
G
A
G
L
R
A
A
M
-
G
L
G
E
A
--
G
F
--
K
T
A
V
V
T
K
M
--
F
P
T
RS
H
T
T
A
---
A
Q
G
G
I
N
A
A
L
G
-
S
M
N
P
D
D
W
K
W
H
F
Y
D
T
A
K
G
S
D
W
L
G
D
Q
N
A
M
H
Y
L
T
R
N
A
V
E
A
V
T
E
L
E
N
F
G
---
M
P
F
S
R
T
P
E
G
K
----
I
Y
Q
R
S
F
G
G
Q
S
-------
N
N
--
Y
G
K
G
G
VAKRTCCVA
D
R
T
----------
G
H
S
M
L
H
T
L
YG
N
S
L
R
---
C
H
---
C
--
T
F
F
--
I
E
Y
F
A
L
D
L
L
M
D
-
K
-------
G
-
R
---------
C
V
G
V
--
I
-
A
L
--
C
L
-
E
D
G
T
I
HR-------------------
F
R
-
S
K
R
T
I
V
A
T
G
G
Y
G
R
A
Y
F
S
C
T
T
A
H
M
N
T
G
D
G
T
A
L
A
T
R
A
G
I
A
L
E
D
L
E
F
I
Q
F
H
P
T
G
I
Y
-----
G
V
G
C
L
I
T
E
G
S
R
G
E
G
G
F
L
V
N
S
E
G
E
R
F
M
E
R
Y
-----
A
P
K
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
A
ETIEI
M
E
G
R
G
V
G
-------
P
E
------
K
D
H
---------
I
Y
L
Q
L
--
H
--
H
L
PA
E
--
Q
L
H
Q
R
L
P
G
I
S
E
T
A
-
K
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
I
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
A
Q
VIKYTKEGGD
K
I
V
P
----------
G
L
Y
A
C
G
E
C
A
C
H
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
A
V
V
F
G
-------
R
A
C
S
I
N
I
K
E
E
L
K
P
D
E
K
-------
I
P
-
E
-----
L
P
---
E
------
G
---
A
G
E
--
E
S
I
A
N
LDAVRYANGDVP
T
A
E
L
--------------
R
L
-------
T
M
Q
K
T
M
Q
K
H
A
G
V
F
R
RGDI
L
----
A
E
G
V
K
K
M
M
---
D
-
L
S
K
E
L
K
R
-------------
L
K
T
T
D
R
SLIWNSDLTE
S
-----
L
E
-------
L
Q
--------------
N
------
L
M
L
-------
N
A
T
Q
T
I
V
A
A
E
-------
N
R
K
E
S
R
G
A
H
A
R
D
D
--
F
--
P
K
R
E
D
E
-
Y
D
Y
S
K
P
I
-
E
G
----------------
4
PsiBlast_PDB
79.25
31%
-94
- C2 -
2E5V
2
NADB_SULTO
A:
[2-469]
-----------
I
Y
I
I
G
S
G
I
A
G
L
S
A
G
V
-
A
L
R
R
A
--
G
K
--
K
V
T
L
I
S
K
R
--
I
D
G
----
G
S
T
P
I
A
K
G
G
V
A
A
S
V
G
---
S
D
D
S
P
E
L
H
A
Q
D
T
I
R
V
G
D
G
L
C
D
V
K
T
V
N
Y
V
T
S
E
A
K
N
V
I
E
T
F
E
S
W
G
---
F
E
F
E
E
D
----------
L
R
L
E
G
G
H
T
-------
K
R
R
V
L
H
R
T
----------
D
E
T
----------
G
R
E
I
F
N
F
L
--
L
K
L
A
R
E
E
G
I
---
P
--
I
I
E
--
D
R
L
V
E
I
R
V
-
K
D
-
G
---------
K
---------
V
T
G
F
--
V
-
T
------
E
K
R
G
L
---------------------
V
E
D
V
D
K
L
V
L
A
T
G
G
Y
S
Y
L
Y
E
Y
S
S
T
Q
S
T
N
I
G
D
G
M
A
I
A
F
K
A
G
T
I
L
A
D
M
E
F
V
Q
F
H
P
T
V
T
---
S
L
D
G
E
V
F
L
L
T
E
T
L
R
G
E
G
A
Q
I
I
N
E
N
G
E
R
F
L
F
N
Y
-----
D
K
R
G
------------
E
-------
L
A
P
R
D
I
L
S
R
A
-----
I
--
Y
I
E
M
-------
L
K
------
G
H
K
---------
V
F
I
D
L
--
S
--
K
I
--
E
--
D
F
E
R
K
F
P
V
V
A
K
Y
L
-
A
-
R
-
H
-
G
H
N
-
Y
K
V
K
I
P
I
F
P
A
A
H
F
V
D
G
G
I
R
V
N
--------
I
R
G
E
----------
S
N
I
V
----------
N
L
Y
A
I
G
E
V
S
D
S
G
L
H
G
A
N
R
L
A
S
N
S
L
L
E
G
L
V
F
G
I
N
LPRYV
D
S
S
W
E
G
I
S
T
D
D
G
I
V
H
S
-------
V
R
-
I
-----
S
G
---
N
------
K
---
T
-----------------------
L
S
--------------
L
K
-------
E
I
R
R
I
N
W
E
N
V
G
I
I
R
----
N
----
E
E
K
L
V
K
A
I
---
N
T
Y
S
S
S
T
Q
N
-------------
E
------------------------------------------------------
A
I
-------
I
S
Y
L
T
A
L
A
A
E
-------
I
R
K
E
S
R
G
N
H
F
R
E
D
--
Y
--
P
Y
K
D
P
N
-
W
E
K
R
I
Y
F
-
K
-----------------
84
PsiBlast_CBE
79.12
31%
-80
- C2 -
3VRA
2
?
A:
[41-593]
--------
A
Y
D
V
V
I
I
G
A
G
G
A
G
L
R
A
A
M
-
G
L
G
E
A
--
G
F
--
K
T
A
V
V
T
K
M
--
F
P
T
RS
H
T
T
A
---
A
Q
G
G
I
N
A
A
L
G
-
S
M
N
P
D
D
W
K
W
H
F
Y
D
T
A
K
G
S
D
W
L
G
D
Q
N
A
M
H
Y
L
T
R
N
A
V
E
A
V
T
E
L
E
N
F
G
---
M
P
F
S
R
T
P
E
G
K
----
I
Y
Q
R
S
F
G
G
Q
S
-------
N
N
--
Y
G
K
G
G
VAKRTCCVA
D
R
T
----------
G
H
S
M
L
H
T
L
Y
G
N
S
L
R
---
C
H
---
C
--
T
F
F
--
I
E
Y
F
A
L
D
L
L
M
D
-
K
-------
G
-
R
---------
C
V
G
V
--
I
-
A
L
--
C
L
-
E
D
G
T
I
H
R
-------------------
F
R
-
S
K
R
T
I
V
A
T
G
G
Y
G
R
A
Y
F
S
C
T
T
A
H
M
N
T
G
D
G
T
A
L
A
T
R
A
G
I
A
L
E
D
L
E
F
I
Q
F
H
P
T
G
I
Y
-----
G
V
G
C
L
I
T
E
G
S
R
G
E
G
G
F
L
V
N
S
E
G
E
R
F
M
E
R
Y
-----
A
P
K
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
A
E
T
I
E
I
M
E
G
R
G
V
G
-------
P
E
------
K
D
H
---------
I
Y
L
Q
L
--
H
--
H
L
P
A
E
--
Q
L
H
Q
R
L
P
G
I
S
E
T
A
-
K
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
I
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
A
Q
V
I
K
Y
T
KEGGD
K
I
V
P
----------
G
L
Y
A
C
G
E
C
A
C
H
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
A
V
V
F
G
-------
R
A
C
S
I
N
I
K
E
E
L
K
P
D
E
K
-------
I
P
-
E
-----
L
P
---
E
------
G
---
A
G
E
--
E
S
I
A
N
L
D
A
V
R
Y
ANGDVP
T
A
E
L
--------------
R
L
-------
T
M
Q
K
T
M
Q
K
H
A
G
V
F
R
R
G
D
I
L
----
A
E
G
V
K
K
M
M
---
D
-
L
S
K
E
L
K
R
-------------
L
K
T
T
D
R
SLIWN
S
D
L
T
E
S
-----
L
E
-------
L
Q
--------------
N
------
L
M
L
-------
N
A
T
Q
T
I
V
A
A
E
-------
N
R
K
E
S
R
G
A
H
A
R
D
D
--
F
--
P
K
R
E
D
E
-
Y
D
Y
S
K
P
I
-
E
G
----------------
82
PsiBlast_CBE
79.06
31%
-80
- C2 -
3VRB
2
?
A:
[41-593]
--------
A
Y
D
V
V
I
I
G
A
G
G
A
G
L
R
A
A
M
-
G
L
G
E
A
--
G
F
--
K
T
A
V
V
T
K
M
--
F
P
T
RS
H
T
T
A
---
A
Q
G
G
I
N
A
A
L
G
-
S
M
N
P
D
D
W
K
W
H
F
Y
D
T
A
K
G
S
D
W
L
G
D
Q
N
A
M
H
Y
L
T
R
N
A
V
E
A
V
T
E
L
E
N
F
G
---
M
P
F
S
R
T
P
E
G
K
----
I
Y
Q
R
S
F
G
G
Q
S
-------
N
N
--
Y
G
K
G
G
VAKRTCCVA
D
R
T
----------
G
H
S
M
L
H
T
L
Y
G
N
S
L
R
---
C
H
---
C
--
T
F
F
--
I
E
Y
F
A
L
D
L
L
M
D
-
K
-------
G
-
R
---------
C
V
G
V
--
I
-
A
L
--
C
L
-
E
D
G
T
I
H
R
-------------------
F
R
-
S
K
R
T
I
V
A
T
G
G
Y
G
R
A
Y
F
S
C
T
T
A
H
M
N
T
G
D
G
T
A
L
A
T
R
A
G
I
A
L
E
D
L
E
F
I
Q
F
H
P
T
G
I
Y
-----
G
V
G
C
L
I
T
E
G
S
R
G
E
G
G
F
L
V
N
S
E
G
E
R
F
M
E
R
Y
-----
A
P
K
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
A
E
T
I
E
I
M
E
G
R
G
V
G
-------
P
E
------
K
D
H
---------
I
Y
L
Q
L
--
H
--
H
L
P
A
E
--
Q
L
H
Q
R
L
P
G
I
S
E
T
A
-
K
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
I
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
A
Q
V
I
K
YTKEGGD
K
I
V
P
----------
G
L
Y
A
C
G
E
C
A
C
H
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
A
V
V
F
G
-------
R
A
C
S
I
N
I
K
E
E
L
K
P
D
E
K
-------
I
P
-
E
-----
L
P
---
E
------
G
---
A
G
E
--
E
S
I
A
N
L
D
A
V
R
Y
ANGDVP
T
A
E
L
--------------
R
L
-------
T
M
Q
K
T
M
Q
K
H
A
G
V
F
R
R
G
D
I
L
----
A
E
G
V
K
K
M
M
---
D
-
L
S
K
E
L
K
R
-------------
L
K
T
T
D
R
SLIWN
S
D
L
T
E
S
-----
L
E
-------
L
Q
--------------
N
------
L
M
L
-------
N
A
T
Q
T
I
V
A
A
E
-------
N
R
K
E
S
R
G
A
H
A
R
D
D
--
F
--
P
K
R
E
D
E
-
Y
D
Y
S
K
P
I
-
E
G
----------------
83
PsiBlast_CBE
79.02
31%
-79
- C2 -
3VRA
2
?
E:
[41-593]
--------
A
Y
D
V
V
I
I
G
A
G
G
A
G
L
R
A
A
M
-
G
L
G
E
A
--
G
F
--
K
T
A
V
V
T
K
M
--
F
P
T
RS
H
T
T
A
---
A
Q
G
G
I
N
A
A
L
G
-
S
M
N
P
D
D
W
K
W
H
F
Y
D
T
A
K
G
S
D
W
L
G
D
Q
N
A
M
H
Y
L
T
R
N
A
V
E
A
V
T
E
L
E
N
F
G
---
M
P
F
S
R
T
P
E
G
K
----
I
Y
Q
R
S
F
G
G
Q
S
-------
N
N
--
Y
G
K
G
G
VAKRTCCVA
D
R
T
----------
G
H
S
M
L
H
T
L
YG
N
S
L
R
---
C
H
---
C
--
T
F
F
--
I
E
Y
F
A
L
D
L
L
M
D
-
K
-------
G
-
R
---------
C
V
G
V
--
I
-
A
L
--
C
L
-
E
D
G
T
I
HR-------------------
F
R
-
S
K
R
T
I
V
A
T
G
G
Y
G
R
A
Y
F
S
C
T
T
A
H
M
N
T
G
D
G
T
A
L
A
T
R
A
G
I
A
L
E
D
L
E
F
I
Q
F
H
P
T
G
I
Y
-----
G
V
G
C
L
I
T
E
G
S
R
G
E
G
G
F
L
V
N
S
E
G
E
R
F
M
E
R
Y
-----
A
P
K
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
A
ETIEI
M
E
G
R
G
V
G
-------
P
E
------
K
D
H
---------
I
Y
L
Q
L
--
H
--
H
L
PA
E
--
Q
L
H
Q
R
L
P
G
I
S
E
T
A
-
K
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
I
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
A
Q
VIKYTKEGGD
K
I
V
P
----------
G
L
Y
A
C
G
E
C
A
C
H
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
A
V
V
F
G
-------
R
A
C
S
I
N
I
K
E
E
L
K
P
D
E
K
-------
I
P
-
E
-----
L
P
---
E
------
G
---
A
G
E
--
E
S
I
A
N
LDAVRYANGDVP
T
A
E
L
--------------
R
L
-------
T
M
Q
K
T
M
Q
K
H
A
G
V
F
R
RGDI
L
----
A
E
G
V
K
K
M
M
---
D
-
L
S
K
E
L
K
R
-------------
L
K
T
T
D
R
SLIWNSDLTE
S
-----
L
E
-------
L
Q
--------------
N
------
L
M
L
-------
N
A
T
Q
T
I
V
A
A
E
-------
N
R
K
E
S
R
G
A
H
A
R
D
D
--
F
--
P
K
R
E
D
E
-
Y
D
Y
S
K
P
I
-
E
G
----------------
85
PsiBlast_CBE
78.73
31%
-77
- C2 -
3VR9
2
?
E:
[41-593]
--------
A
Y
D
V
V
I
I
G
A
G
G
A
G
L
R
A
A
M
-
G
L
G
E
A
--
G
F
--
K
T
A
V
V
T
K
M
--
F
P
T
RS
H
T
T
A
---
A
Q
G
G
I
N
A
A
L
G
-
S
M
N
P
D
D
W
K
W
H
F
Y
D
T
A
K
G
S
D
W
L
G
D
Q
N
A
M
H
Y
L
T
R
N
A
V
E
A
V
T
E
L
E
N
F
G
---
M
P
F
S
R
T
P
E
G
K
----
I
Y
Q
R
S
F
G
G
Q
S
-------
N
N
--
Y
G
K
G
G
VAKRTCCVA
D
R
T
----------
G
H
S
M
L
H
T
L
YG
N
S
L
R
---
C
H
---
C
--
T
F
F
--
I
E
Y
F
A
L
D
L
L
M
D
-
K
-------
G
-
R
---------
C
V
G
V
--
I
-
A
L
--
C
L
-
E
D
G
T
I
HR-------------------
F
R
-
S
K
R
T
I
V
A
T
G
G
Y
G
R
A
Y
F
S
C
T
T
A
H
M
N
T
G
D
G
T
A
L
A
T
R
A
G
I
A
L
E
D
L
E
F
I
Q
F
H
P
T
G
I
Y
-----
G
V
G
C
L
I
T
E
G
S
R
G
E
G
G
F
L
V
N
S
E
G
E
R
F
M
E
R
Y
-----
A
P
K
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
A
ETIEI
M
E
G
R
G
V
G
-------
P
E
------
K
D
H
---------
I
Y
L
Q
L
--
H
--
H
L
PA
E
--
Q
L
H
Q
R
L
P
G
I
S
E
T
A
-
K
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
I
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
A
Q
VIKYTKEGGD
K
I
V
P
----------
G
L
Y
A
C
G
E
C
A
C
H
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
A
V
V
F
G
-------
R
A
C
S
I
N
I
K
E
E
L
K
P
D
E
K
-------
I
P
-
E
-----
L
P
---
E
------
G
---
A
G
E
--
E
S
I
A
N
LDAVRYANGDVP
T
A
E
L
--------------
R
L
-------
T
M
Q
K
T
M
Q
K
H
A
G
V
F
R
RGDI
L
----
A
E
G
V
K
K
M
M
---
D
-
L
S
K
E
L
K
R
-------------
L
K
T
T
D
R
SLIWNSDLTE
S
-----
L
E
-------
L
Q
--------------
N
------
L
M
L
-------
N
A
T
Q
T
I
V
A
A
E
-------
N
R
K
E
S
R
G
A
H
A
R
D
D
--
F
--
P
K
R
E
D
E
-
Y
D
Y
S
K
P
I
-
E
G
----------------
113
HHSearch
77.95
34%
-80
- C2 -
2WDQ
4
SDHA_ECOLI
A:
[3-559]
----
L
P
V
R
E
F
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
-
Q
I
S
Q
S
--
G
Q
--
T
C
A
L
L
S
K
V
--
F
P
---
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
-
H
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
---
L
P
F
S
R
L
D
D
G
R
----
I
Y
Q
R
P
F
G
G
Q
S
KNFGG
E
Q
A
A
R
T
A
A
A
-
A
---------
D
R
T
----------
G
H
A
L
L
H
T
L
--
Y
Q
Q
N
---
L
K
---
N
HT
T
I
F
--
S
E
W
Y
A
L
D
L
V
K
N
Q
D
-------
G
-
A
---------
V
V
G
C
T
-
A
L
C
I
--
E
T
-
G
E
V
V
Y
---------------------
F
K
-
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
A
G
A
G
-----
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
-----
A
P
N
A
K-----------
D
-------
L
A
G
R
D
V
V
A
R
S
-----
I
M
I
E
I
R
E
-------
G
R
G
C
D
G
PW
G
P
H
---------
A
K
L
K
L
--
D
--
H
L
--
G
K
E
V
L
E
S
R
L
P
G
I
L
E
L
S
-
R
-
T
F
A
-
H
V
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
A
L
T
V
N
EKG
E
D
V
V
V
P
----------
G
L
F
A
V
G
E
I
A
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
-------
R
A
A
G
L
H
L
Q
E
S
I
A
E
Q
G
A
-------
L
R
D
A
S
E
S
--
D
V
E
A
S
L
------
D
R
L
N
R
W
N
N
N
R
N
G
E
D
------------
P
V
A
I
--------------
R
K
-------
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
----
E
----
G
D
A
M
A
K
G
L
---
E
Q
L
K
V
I
R
E
R
L
K
N
ARLDDTSSEF
N
T
Q
R
V
E
----------
C
-----
L
E
-------
L
D
--------------
N
------
L
M
E
-------
T
A
Y
A
T
A
V
S
A
N
-------
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
--
P
D
R
D
D
E
N
W
L
C
H
S
L
Y
-------------------
114
HHSearch
77.67
32%
-90
- C2 -
2E5V
2
NADB_SULTO
A:
[1-468]
----------
M
I
Y
I
I
G
S
G
I
A
G
L
S
A
G
V
-
A
L
R
R
A
--
G
K
--
K
V
T
L
I
S
K
R
--
I
----
D
G
G
S
T
P
I
A
K
G
G
V
A
A
S
V
G
-
S
--
D
D
S
P
E
L
H
A
Q
D
T
I
R
V
G
D
G
L
C
D
V
K
T
V
N
Y
V
T
S
E
A
K
N
V
I
E
T
F
E
S
W
G
---
F
E
F
E
E
D
L
-
R
---------
L
E
G
G
H
T
-------
K
R
R
V
L
H
R
-
T
---------
D
E
T
----------
G
R
E
I
F
N
F
L
--
L
K
L
A
---
R
E
---
E
G
I
P
I
I
--
E
D
-
R
L
V
E
I
R
V
K
-
D
-------
G
-
K
---------
V
T
G
F
V
-
T
-
E
K
---
R
-
G
--
L
V
---------------------
E
D
-
V
D
K
L
V
L
A
T
G
G
Y
S
Y
L
Y
E
Y
S
S
T
Q
S
T
N
I
G
D
G
M
A
I
A
F
K
A
G
T
I
L
A
D
M
E
F
V
Q
F
H
P
T
V
T
S
L
D
G
E
---
V
F
L
L
T
E
T
L
R
G
E
G
A
Q
I
I
N
E
N
G
E
R
F
L
F
N
Y
-----
D
K
R
G
------------
E
-------
L
A
P
R
D
I
L
S
R
A
-----
I
Y
I
E
M
L
K
-------
G
--------
H
K
---------
V
F
I
D
L
--
S
--
K
I
--
E
--
D
F
E
R
K
F
P
V
V
A
K
Y
L
-
A
-
R
-
H
-
G
H
N
Y
K
-
V
K
I
P
I
F
P
A
A
H
F
V
D
G
G
I
R
V
N
--------
I
R
G
E
----------
S
N
I
V
----------
N
L
Y
A
I
G
E
V
S
D
S
G
L
H
G
A
N
R
L
A
S
N
S
L
L
E
G
L
V
F
G
-------
I
N
L
P
R
Y
V
D
S
S
W
E
G
I
S
T
-------
D
D
-
G
-----
I
V
---
H
------
S
----
V
R
---
I
S
G
N
------------
K
T
L
S
--------------
L
K
-------
E
I
R
R
I
N
W
E
N
V
G
I
I
R
----
N
----
E
E
K
L
V
K
A
I
---
N
T
Y
S
S
S
T
-----------------------------------------------
Q
--------------
N
------
E
A
I
-------
I
S
Y
L
T
A
L
A
A
E
-------
I
R
K
E
S
R
G
N
H
F
R
E
D
--
Y
--
P
Y
K
D
P
N
-
W
E
K
R
I
Y
F
-------------------
103
Fugue
77.52
36%
-98
- C2 -
1CHU
-
NADB_ECOLI
A:
[2-533]
--
N
T
L
P
E
H
S
C
D
V
L
I
I
G
S
G
A
A
G
L
S
L
A
L
-
R
L
A
D
-----Q
H
Q
V
I
V
L
S
K
G
---
P
V
--
T
E
F
D
E
----------------
T
D
S
I
D
S
H
V
E
D
T
L
I
A
G
A
G
I
C
D
R
H
A
V
E
F
V
A
S
N
A
R
S
C
V
Q
W
L
I
D
Q
G
---
V
L
-----------------------------------------------------------------
T
T
L
--
V
S
K
A
---
L
N
HPN
I
--
R
V
L
--
E
R
T
N
A
V
D
L
I
V
----------
S
-
D
KIGLPGTRR
V
V
G
A
--
W
-
V
W
N
R
N
K
-
E
T
V
E
T
---------------------
C
H
-
A
K
A
V
V
L
A
T
G
G
A
S
K
V
Y
Q
Y
T
T
N
P
D
I
S
S
G
D
G
I
A
M
A
W
R
A
G
C
R
V
A
N
L
E
F
N
Q
F
H
P
T
A
L
Y
H
P
Q
A
R
N
--
F
L
L
T
E
A
L
R
G
E
G
A
Y
L
K
R
P
D
G
T
R
F
M
P
D
F
-----
D
E
R
G
------------
E
-------
L
A
P
R
D
I
V
A
R
A
-----
I
D
H
E
M
K
R
-------
L
G
------
A
D
C
---------
M
F
L
D
I
--
S
HK
P
A
--
D
--
F
I
R
Q
H
F
P
M
I
Y
E
K
L
-
L
-
G
--
L
G
I
D
L
T
Q
E
P
V
P
I
V
P
A
A
H
Y
T
C
G
G
V
M
V
D
--------
D
H
G
R
----------
T
D
V
E
----------
G
L
Y
A
I
G
E
V
S
Y
T
G
L
H
G
A
N
R
M
A
S
N
S
L
L
E
C
L
V
Y
G
-------
W
S
A
A
E
D
I
T
R
R
M
H
D
I
S
T
-------
L
P
-
P
-----
W
D
---
E
------
S
---
R
V
E
--
N
-----------------
P
D
E
--------------
R
V
V
I
Q
H
N
W
H
E
L
R
L
F
M
W
D
Y
V
G
I
V
R
----
T
----
T
K
R
L
E
R
A
L
---
R
R
I
T
M
L
Q
Q
E
I
D
E
YYAH------
F
R
V
S
N
N
----------
L
-----
L
E
-------
L
R
--------------
N
------
L
V
Q
-------
V
A
E
L
I
V
R
C
A
M
-------
M
R
K
E
S
R
G
L
H
F
T
L
D
---YP
E
L
L
T
---
H
S
G
P
S
I
L
-
S
P
----------------
9
PsiBlast_PDB
77.03
33%
-86
- C2 -
3P4R
2
FRDA_ECOLI
A:
[32-541]
--------------------------------------
K
I
A
L
I
S
K
V
YP
M
R
S
--
H
T
V
A
---
A
E
G
G
S
A
A
V
A
Q
-
D
-
H
D
-
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
---
C
P
W
S
R
R
P
D
G
S
----
V
N
V
R
R
F
G
G
M
K
-------
I
E
R
T
W
F
A
A
----------
D
K
T
----------
G
F
H
M
L
H
T
L
F
-
Q
T
S
L
---
Q
F
---
P
--
Q
I
Q
RF
D
E
H
F
V
L
D
I
L
V
D
-
D
-------
G
-
H
---------
V
R
G
L
--
V
-
A
M
--
N
M
M
E
G
T
L
V
Q
--------------------
I
R
-
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
-----
P
G
S
G
I
L
M
T
E
G
C
R
G
E
G
G
I
L
V
N
K
N
G
Y
R
Y
L
Q
D
Y
GMGPE
T
P
L
G
------------
E
P
K
N
KYME
L
G
P
R
D
K
V
S
Q
A
-----
F
W
H
E
W
R
K
GN
T
I
S
T
P
R
G
------
D
-
V
---------
V
Y
L
D
L
--
R
HL
G
E
--
K
--
K
L
H
E
R
L
P
F
I
C
E
L
A
-
K
-
A
Y
V
-
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
D
--------
Q
N
C
E
----------
T
R
I
K
----------
G
L
F
A
V
G
E
C
S
S
V
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
-------
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
G
N
-------
G
N
-
E
-----
A
A
---
I
------
E
---
A
Q
A
--
A
G
V
E
Q
------------
R
L
K
D
L
V
N
QDGGEN
W
A
K
I
-
R
D
-------
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
----
T
----
P
E
L
M
Q
K
T
I
---
D
K
L
A
E
L
Q
E
R
-------------
F
K
R
V
R
I
----------
T
DTSSV
F
N
T
------
D
L
--------------
L
------
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
-------
A
R
K
E
S
R
G
A
H
Q
R
L
D
--
E
--
G
C
T
------------------------------
111
HHSearch
76.98
39%
-89
- C2 -
1CHU
-
NADB_ECOLI
A:
[2-533]
--
N
T
L
P
E
H
S
C
D
V
L
I
I
G
S
G
A
A
G
L
S
L
A
L
-
R
L
A
D
Q
--
H
---
Q
V
I
V
L
S
K
G
--
P
V
---
T
E
-------------
F
D
-
E
--
T
D
S
I
D
S
H
V
E
D
T
L
I
A
G
A
G
I
C
D
R
H
A
V
E
F
V
A
S
N
A
R
S
C
V
Q
W
L
I
D
Q
G
---
V
L
-----------------------------------------------------------------
T
T
L
--
V
S
K
A
---
L
N
HP-
N
I
-
R
V
L
--
E
R
T
N
A
V
D
L
I
V
S
-
D
KIGLPGT
R
-
R
---------
V
V
G
A
W
-
V
W
N
R
--
N
K
-
E
T
V
E
T
---------------------
C
H
-
A
K
A
V
V
L
A
T
G
G
A
S
K
V
Y
Q
Y
T
T
N
P
D
I
S
S
G
D
G
I
A
M
A
W
R
A
G
C
R
V
A
N
L
E
F
N
Q
F
H
P
T
A
L
Y
H
P
Q
A
--
R
N
F
L
L
T
E
A
L
R
G
E
G
A
Y
L
K
R
P
D
G
T
R
F
M
P
D
F
-----
D
E
R
G
------------
E
-------
L
A
P
R
D
I
V
A
R
A
-----
I
D
H
E
M
K
R
-------
L
G
------
A
D
C
---------
M
F
L
D
I
--
S
--
H
K
--
P
AD
F
I
R
Q
H
F
P
M
I
Y
E
K
L
-
L
-
G
-
L
-
G
I
D
L
T
Q
E
P
V
P
I
V
P
A
A
H
Y
T
C
G
G
V
M
V
D
--------
D
H
G
R
----------
T
D
V
E
----------
G
L
Y
A
I
G
E
V
S
Y
T
G
L
H
G
A
N
R
M
A
S
N
S
L
L
E
C
L
V
Y
G
-------
W
S
A
A
E
D
I
T
R
R
M
---
H
D
-------
I
S
-
T
L
P
---
P
W
---
D
E-----
S
---
R
V
E
N
P
D
E
R
V
V
------------
I
Q
H
N
--------------
W
H
-------
E
L
R
L
F
M
W
D
Y
V
G
I
V
R
----
T
----
T
K
R
L
E
R
A
L
---
R
R
I
T
M
L
Q
Q
E
I
D
E
YYAH------
F
R
V
S
N
N
----------
L
-----
L
E
-------
L
R
--------------
N
------
L
V
Q
-------
V
A
E
L
I
V
R
C
A
M
-------
M
R
K
E
S
R
G
L
H
F
T
L
D
--
Y
--
P
E
L
L
T
H
-
S
G
P
S
I
L
S
-
P
-----------------
18
PsiBlast_PDB
76.06
31%
-78
- C2 -
2WDV
3
SDHA_ECOLI
A:
[9-555]
----------
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
-
Q
I
S
Q
S
--
G
Q
--
T
C
A
L
L
S
K
V
--
F
P
T
--
R
-
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
-
N
T
H
E
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
LP
F
S
R
L
D
D
---
G
R
----
I
Y
Q
R
P
F
G
G
Q
S
-------
K
----
N
F
G
G
---------
E
Q
A
A
R
TAAAADR
T
G
H
A
L
L
H
T
L
Y
Q
Q
N
L
K
---
N
H
---
T
--
T
I
F
--
S
E
W
Y
A
L
D
L
V
K
N
-
Q
-------
D
G
A
---------
V
V
G
C
T
A
L
-
C
I
--
E
T
-
G
E
V
V
Y
---------------------
F
K
-
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
V
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
-----
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
-----
A
P
N
A
K-----------
D
-------
L
A
G
R
D
V
V
A
R
S
-----
I
M
I
E
I
R
E
--------
G
------
R
G
C
D
G
PW
G
P
H
A
K
L
K
L
D
H
--
L
--
G
K
--
E
--
V
L
E
S
R
L
P
G
I
L
E
L
S
-
R
-
T
F
A
-
H
V
D
P
V
K
E
P
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
K
--------
V
T
G
Q
----------
A
L
T
V
N
EKG
E
D
V
V
VP
G
L
F
A
V
G
E
I
A
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
-------
R
A
A
G
L
H
L
Q
E
S
I
A
E
Q
G
A
-------
L
R
-
D
-----
A
S
---
E
------
S
---
D
V
E
--
A
S
L
D
R
------------
L
N
R
W
N
N
NRNGED
P
V
A
I
--
R
K
-------
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
----
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
-------------
D
T
S
S
E
F
----------
N
-----
T
Q
-------
R
V
--------------
E
C
L
E
L
D
N
L
M
E
-------
T
A
Y
A
T
A
V
S
A
N
-------
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
--
P
---------------
D
R
D
D
E
N
W
L
C
--------
12
PsiBlast_PDB
76.05
33%
-88
- C2 -
3P4S
2
FRDA_ECOLI
A:
[32-541]
--------------------------------------
K
I
A
L
I
S
K
V
YP
M
R
S
--
H
T
V
A
---
A
E
G
G
S
A
A
V
A
Q
-
D
-
H
D
-
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
---
C
P
W
S
R
R
P
D
G
S
----
V
N
V
R
R
F
G
G
M
K
-------
I
E
R
T
W
F
A
A
----------
D
K
T
----------
G
F
H
M
L
H
T
L
F
-
Q
T
S
L
---
Q
F
---
P
--
Q
I
Q
RF
D
E
H
F
V
L
D
I
L
V
D
-
D
-------
G
-
H
---------
V
R
G
L
--
V
-
A
M
--
N
M
M
E
G
T
L
V
Q
--------------------
I
R
-
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
V
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
-----
P
G
S
G
I
L
M
T
E
G
C
R
G
E
G
G
I
L
V
N
K
N
G
Y
R
Y
L
Q
D
Y
GMGPE
T
P
L
G
------------
E
P
K
N
KYME
L
G
P
R
D
K
V
S
Q
A
-----
F
W
H
E
W
R
K
GN
T
I
S
T
P
R
G
------
D
-
V
---------
V
Y
L
D
L
--
R
HL
G
E
--
K
--
K
L
H
E
R
L
P
F
I
C
E
L
A
-
K
-
A
Y
V
-
G
V
D
P
V
K
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
D
--------
Q
N
C
E
----------
T
R
I
K
----------
G
L
F
A
V
G
E
C
S
S
V
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
-------
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
G
N
-------
G
N
-
E
-----
A
A
---
I
------
E
---
A
Q
A
--
A
G
V
E
Q
------------
R
L
K
D
L
V
N
QDGGEN
W
A
K
I
-
R
D
-------
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
----
T
----
P
E
L
M
Q
K
T
I
---
D
K
L
A
E
L
Q
E
R
-------------
F
K
R
V
R
I
----------
T
DTSSV
F
N
T
------
D
L
--------------
L
------
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
-------
A
R
K
E
S
R
G
A
H
Q
R
L
D
--
E
--
G
C
T
------------------------------
77
PsiBlast_CBE
74.08
31%
-84
- C2 -
1ZP0
2
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
FANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
74
PsiBlast_CBE
74.03
31%
-83
- C2 -
3AE2
2
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHR
C
C
C
VA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
HR-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKDH---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
79
PsiBlast_CBE
74.00
31%
-82
- C2 -
4YXD
1
?
A:
[103-612]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEK
D
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
----
L
R
L
Y
G
----------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
78
PsiBlast_CBE
73.83
31%
-84
- C2 -
1ZOY
1
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
FANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
60
PsiBlast_CBE
73.68
31%
-82
- C2 -
3AEG
1
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
Q
A
H
RCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
61
PsiBlast_CBE
73.60
31%
-83
- C2 -
3AEF
1
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKDH---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
64
PsiBlast_CBE
73.57
31%
-82
- C2 -
3AEC
1
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHR
C
C
C
VA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
HR-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
63
PsiBlast_CBE
73.55
31%
-81
- C2 -
3AED
2
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YK
G
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
70
PsiBlast_CBE
73.48
31%
-81
- C2 -
3AE6
1
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHR
C
C
C
VA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
76
PsiBlast_CBE
73.43
31%
-84
- C2 -
3ABV
2
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHR
C
C
C
VA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKDH---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
59
PsiBlast_CBE
73.29
31%
-82
- C2 -
3SFD
2
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEK
D
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
58
PsiBlast_CBE
73.28
31%
-82
- C2 -
3SFE
2
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
A
N
G
TIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
72
PsiBlast_CBE
73.19
31%
-82
- C2 -
3AE4
2
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHR
C
C
C
VA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YK
G
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
75
PsiBlast_CBE
73.17
31%
-82
- C2 -
3AE1
2
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHR
C
C
C
VA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
67
PsiBlast_CBE
73.09
31%
-80
- C2 -
3AE9
2
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHR
C
C
C
VA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
A
N
G
TIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
80
PsiBlast_CBE
73.07
31%
-81
- C2 -
4YTP
1
SDHA_PIG
A:
[103-612]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
HR-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
----
L
R
L
Y
G
----------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
65
PsiBlast_CBE
73.03
31%
-83
- C2 -
3AEB
2
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
HR-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
68
PsiBlast_CBE
72.75
31%
-80
- C2 -
3AE8
1
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
Q
A
H
R
C
C
C
VA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
A
N
G
T
I
R
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
62
PsiBlast_CBE
72.58
31%
-81
- C2 -
3AEE
1
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHR
C
C
C
VA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
HR-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKGQ
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
69
PsiBlast_CBE
72.56
31%
-77
- C2 -
3AE7
1
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
73
PsiBlast_CBE
72.54
31%
-81
- C2 -
3AE3
1
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHR
C
C
C
VA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
57
PsiBlast_CBE
72.38
31%
-79
- C2 -
1YQ3
5
SDHA_CHICK
A:
[60-569]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
D
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
A
V
I
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
E
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
Q
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
T
I
H
R
-------------------
F
R
-
A
K
N
T
V
I
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
I
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
Q
--
Q
L
A
T
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
G
Q
V
I
T
H
V
NG
E
D
-
K
V
V
P
----------
G
L
Y
A
C
G
E
A
A
S
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
T
I
A
E
T
C
K
P
G
E
PVPSIKP
N
A
-
G
-----
E
E
---
S
------
V
---
A
N
L
--
D
K
L
R
F
A
D
G
TIR------
T
S
E
A
--------------
R
L
-------
N
M
Q
K
T
M
Q
S
H
A
A
V
F
R
----
T
----
G
S
I
L
Q
E
G
C
---
E
K
L
S
Q
I
-
Y
R
-------------
D
L
A
H
L
K
----------
T
-----
F
D
RGIVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
Y
--
K
L
R
I
D
E
-
F
D
Y
S
K
P
L
-
Q
G
----------------
71
PsiBlast_CBE
72.29
31%
-78
- C2 -
3AE5
2
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
Q
A
H
R
C
C
C
VA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
H
R
-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
PP
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
ANGTIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
66
PsiBlast_CBE
72.26
31%
-81
- C2 -
3AEA
2
SDHA_PIG
A:
[61-570]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
E
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
S
V
V
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
D
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
K
--
F
G
K
G
G
QAHR
C
C
C
VA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
S
I
HR-------------------
I
R
-
A
R
N
T
V
V
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
L
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
E
--
Q
L
A
V
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
YKG
Q
V
L
R
H
V
N
G
Q
----------
D
Q
V
V
P
---------
G
L
Y
A
C
G
E
A
A
C
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
S
I
A
E
S
C
R
P
G
D
-------
K
V
-
P
-----
S
I
---
K
------
P
---
N
A
G
--
E
E
-
S
V
------------
M
N
L
D
K
L
R
F
A
N
G
TIR
T
S
E
L
R
L
-------
S
M
Q
K
S
M
Q
S
H
A
A
V
F
R
----
V
----
G
S
V
L
Q
E
G
C
---
E
K
I
L
R
L
-
Y
G
-------------
D
L
Q
H
L
K
----------
T
-----
F
D
RGMVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
F
--
K
E
R
V
D
E
-
Y
D
Y
S
K
P
I
-
Q
G
----------------
56
PsiBlast_CBE
70.92
31%
-77
- C2 -
1YQ4
2
SDHA_CHICK
A:
[60-569]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
D
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
A
V
I
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
E
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
Q
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
YF
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
T
I
H
R
-------------------
F
R
-
A
K
N
T
V
I
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
I
E
I
R
E
--------
G
------
R
G
C
GPEKDH---
V
Y
L
Q
L
--
H
--
H
L
P
P
Q
--
Q
L
A
T
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
G
Q
V
I
T
H
V
NG
E
D
-
K
V
V
P
----------
G
L
Y
A
C
G
E
A
A
S
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
T
I
A
E
T
C
K
P
G
E
PV
P
S
I
K
P
N
A
-
G
-----
E
E
---
S
------
V
---
A
N
L
--
D
K
L
R
F
ADGTIR------
T
S
E
A
--------------
R
L
-------
N
M
Q
K
T
M
Q
S
H
A
A
V
F
R
----
T
----
G
S
I
L
Q
E
G
C
---
E
K
L
S
Q
I
-
Y
R
-------------
D
L
A
H
L
K
----------
T
-----
F
D
RGIVWN
T
D
L
--------------
V
------
E
T
L
-------
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
--
Y
--
K
L
R
I
D
E
-
F
D
Y
S
K
P
L
-
Q
G
----------------
51
PsiBlast_CBE
70.73
31%
-78
- C2 -
2H89
14
SDHA_CHICK
A:
[60-569]
------------------------------------------------------------
A
Q
G
G
I
N
A
A
L
G
-
N
M
E
D
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
A
V
I
E
L
E
N
Y
G
---
M
P
F
S
R
T
E
E
G
K
----
I
Y
Q
R
A
F
G
G
Q
S
-------
L
Q
--
F
G
K
G
G
QAHRCCCVA
D
R
T
----------
G
H
S
L
L
H
T
L
--
Y
G
R
S
---
L
R
---
Y
--
D
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
-
N
-------
G
-
E
---------
C
R
G
V
--
I
-
A
L
--
C
I
-
E
D
G
T
I
H
R
-------------------
F
R
-
A
K
N
T
V
I
A
T
G
G
Y
G
R
T
Y
F
S
C
T
S
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
-----
G
A
G
C
L
I
T
E
G
C
R
G
E
G
G
I
L
I
N
S
Q
G
E
R
F
M
E
R
Y
-----
A
P
V
A
K-----------
D
-------
L
A
S
R
D
V
V
S
R
S
-----
M
T
I
E
I
R
E
--------
G
------
R
G
C
GPEKD
H
---
V
Y
L
Q
L
--
H
--
H
L
P
P
Q
--
Q
L
A
T
R
L
P
G
I
S
E
T
A
-
M
I
F
-
A
-
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
Y
N
M
G
G
I
P
T
N
--------
Y
K
G
Q
V
I
T
H
V
NG
E
D
-
K
V
V
P
----------
G
L
Y
A
C
G
E
A
A
S
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
-
L
V
V
F
-------
G
R
A
C
A
L
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----------------