@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1596: (2016-05-03 )
MGLSDWELAAARAAIARGLDEDLRYGPDVTTLATVPASATTTASLVTREAGVVAGLDVALLTLNEVLGTNGYRVLDRVEDGARVPPGEALMTLEAQTRGLLTAERTMLNLVGHLSGIATATAAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRTGGGVNHRLGLGDAALIKDNHVAAAGSVVDALRAVRNAAPDLPCEVEVDSLEQLDAVLPEKPELILLDNFAVWQTQTAVQRRDSRAPTVMLESSGGLSLQTAATYAETGVDYLAVGALTHSVRVLDIGLDM
Atome Classification :
(43 SA)
.........10.......----.20..----...-----...30........40........50....---....60........70.......--.80........90........100.......110.......120.......130-........140.......150.......160.......170.......180.......190..-.-....200.......210.......220.......230.......240.......250.......260.......270.......280...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGL
S
D
W
E
L
A
A
A
R
A
A
I
A
RG----
L
D
E
D
L----RYG-----PDV
T
T
L
A
TVPASAT
T
T
A
S
L
V
T
REAGVVA
G
---
L
D
V
A
L
L
T
L
N
E
V
LGTNG
Y
R
V
L
D
RV--EDGARVPPG
E
A
L
M
T
L
EAQTRG
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
VRGT--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
VRTGGGVNHRLGLG
D
A
A
L
IKDNHVA
A
A
G
S
V
V
D
A
L
R
A
V
R
NAAP-D-LPC
E
V
E
V
D
S
L
E
Q
L
D
A
VLPEKP
E
L
I
L
L
DNFAV
W
Q
T
Q
T
A
V
Q
RRDSRA
P
T
V
M
L
ESSGG
L
S
L
Q
T
A
A
T
Y
A
ET
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
DIGLDM
22
PsiBlast_CBE
99.82
100%
-108
- C7 -
1QPR
5
NADC_MYCTU
E:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
33
PsiBlast_CBE
99.66
100%
-106
- C7 -
1QPO
1
NADC_MYCTU
D:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
32
PsiBlast_CBE
99.57
100%
-107
- C7 -
1QPO
1
NADC_MYCTU
E:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
31
PsiBlast_CBE
99.53
100%
-104
- C7 -
1QPO
1
NADC_MYCTU
F:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
1
PsiBlast_PDB
99.49
100%
-106
- C7 -
1QPR
6
NADC_MYCTU
A:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
34
PsiBlast_CBE
99.44
100%
-105
- C7 -
1QPO
1
NADC_MYCTU
C:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
25
PsiBlast_CBE
99.43
100%
-106
- C7 -
1QPR
6
NADC_MYCTU
B:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
24
PsiBlast_CBE
99.43
100%
-106
- C7 -
1QPR
6
NADC_MYCTU
C:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
35
PsiBlast_CBE
99.42
100%
-105
- C7 -
1QPO
1
NADC_MYCTU
B:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
23
PsiBlast_CBE
99.38
100%
-107
- C7 -
1QPR
6
NADC_MYCTU
D:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
27
PsiBlast_CBE
99.29
100%
-106
- C7 -
1QPQ
3
NADC_MYCTU
E:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
21
PsiBlast_CBE
99.26
100%
-108
- C7 -
1QPR
6
NADC_MYCTU
F:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
30
PsiBlast_CBE
99.16
100%
-103
- C7 -
1QPQ
3
NADC_MYCTU
B:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
2
PsiBlast_PDB
99.07
100%
-107
- C7 -
1QPN
1
NADC_MYCTU
A:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
40
PsiBlast_CBE
99.05
100%
-106
- C7 -
1QPN
1
NADC_MYCTU
B:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
29
PsiBlast_CBE
99.03
100%
-107
- C7 -
1QPQ
3
NADC_MYCTU
C:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
4
PsiBlast_PDB
99.03
100%
-105
- C7 -
1QPQ
3
NADC_MYCTU
A:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
28
PsiBlast_CBE
99.01
100%
-105
- C7 -
1QPQ
3
NADC_MYCTU
D:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
3
PsiBlast_PDB
99.01
100%
-106
- C7 -
1QPO
1
NADC_MYCTU
A:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
39
PsiBlast_CBE
98.90
100%
-107
- C7 -
1QPN
1
NADC_MYCTU
C:
[1-284]
-
G
L
S
D
W
E
L
A
A
A
R
A
A
I
A
R
G
----
L
D
E
D
L
----
R
Y
G
-----
P
D
V
T
T
L
A
T
V
P
A
S
A
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
---
L
D
V
A
L
L
T
L
N
E
V
L
G
T
N
G
Y
R
V
L
D
R
V
--
E
D
G
A
R
V
P
P
G
E
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
P
-
D
-
L
P
C
E
V
E
V
D
S
L
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
T
A
V
Q
R
R
D
S
R
A
P
T
V
M
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
102
HHSearch
78.29
42%
-91
- C7 -
1QAP
2
NADC_SALTY
A:
[15-295]
---
L
E
R
I
N
L
D
I
P
A
A
V
A
Q
A
----
L
R
E
D
L
----
G
-
G
EVDAG
N
D
I
T
A
Q
L
-
L
P
A
D
T
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
---
K
R
W
V
E
E
V
F
I
-
Q
L
A
G
D
D
V
R
L
T
W
H
V
--
D
D
G
D
A
I
H
A
N
Q
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
T
--
Q
T
Q
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
P
-
D
-
V
P
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
T
D
Q
M
R
E
A
V
K
R
V
---
N
G
Q
A
R
L
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
6
PsiBlast_PDB
77.63
42%
-93
- C7 -
1QAP
2
NADC_SALTY
A:
[24-293]
------------
A
A
V
A
Q
A
----
L
R
E
D
L
GGEV
D
A
G
-----
N
D
I
T
A
-
Q
L
L
P
A
D
T
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
---
K
R
W
V
E
E
V
F
I
Q
L
A
G
D
D
-
V
R
L
T
W
H
V
--
D
D
G
D
A
I
H
A
N
Q
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
T
--
Q
T
Q
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
P
-
D
-
V
P
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
T
D
Q
M
R
E
A
V
K
R
V
N
G
Q
A
---
R
L
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
--
41
PsiBlast_CBE
77.45
42%
-96
- C7 -
1QAP
1
NADC_SALTY
B:
[24-293]
------------
A
A
V
A
Q
A
----
L
R
E
D
L
GGEV
D
A
G
-----
N
D
I
T
A
-
Q
L
L
P
A
D
T
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
---
K
R
W
V
E
E
V
F
I
Q
L
A
G
D
D
-
V
R
L
T
W
H
V
--
D
D
G
D
A
I
H
A
N
Q
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
T
--
Q
T
Q
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
P
-
D
-
V
P
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
T
D
Q
M
R
E
A
V
K
R
V
N
G
Q
A
---
R
L
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
--
103
HHSearch
76.13
36%
-93
- C7 -
3L0G
2
?
A:
[24-294]
--------
I
S
F
S
E
I
I
H
N
A
----
L
K
E
D
L
----
G
D
K
-----
G
D
I
T
T
N
S
I
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
---
I
P
I
L
E
E
V
F
N
-
M
N
-
K
E
H
V
K
Y
E
I
H
K
--
K
D
G
D
I
T
G
K
N
S
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
--
K
V
K
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
-
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
K
K
A
V
D
I
V
---
N
G
K
S
V
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
12
PsiBlast_PDB
75.77
37%
-87
- C7 -
3L0G
2
?
A:
[30-294]
--------------
I
H
N
A
----
L
K
E
D
L
----
G
D
K
-----
G
D
I
T
T
-
N
S
I
L
I
N
E
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
---
I
P
I
----
L
E
E
V
F
N
M
N
K
E
H
V
K
Y
E
I
HK
K
D
G
D
I
T
G
K
N
S
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
--
K
V
K
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
-
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
K
K
A
V
D
I
V
N
G
K
S
---
V
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
104
HHSearch
75.70
36%
-95
- C7 -
2B7N
2
NADC_HELPY
A:
[2-272]
---------
E
I
R
T
F
L
E
R
A
----
L
K
E
D
L
----
G
-
H
-----
G
D
L
F
E
R
V
-
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
---
E
K
Y
A
L
E
L
L
E
-
M
T
G
---
I
E
C
V
Q
T
I
--
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
-
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
H
Y
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
44
PsiBlast_CBE
75.31
35%
-94
- C7 -
2B7P
2
NADC_HELPY
C:
[4-272]
-----------
R
T
F
L
E
R
A
----
L
K
E
D
L
----
G
H
G
-----
D
L
F
E
R
V
--
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
---
E
K
Y
A
L
----
E
L
L
E
M
T
G
I
E
C
V
Q
T
I
--
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
H
Y
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
48
PsiBlast_CBE
75.09
37%
-85
- C7 -
3L0G
2
?
D:
[30-294]
--------------
I
H
N
A
----
L
K
E
D
L
----
G
D
K
-----
G
D
I
T
T
-
N
S
I
L
I
N
E
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
---
I
P
I
----
L
E
E
V
F
N
M
N
K
E
H
V
K
Y
E
I
HK
K
D
G
D
I
T
G
K
N
S
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
--
K
V
K
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
-
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
K
K
A
V
D
I
V
N
G
K
S
---
V
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
42
PsiBlast_CBE
75.08
35%
-92
- C7 -
2B7Q
1
NADC_HELPY
C:
[4-272]
-----------
R
T
F
L
E
R
A
----
L
K
E
D
L
----
G
H
G
-----
D
L
F
E
R
V
--
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
---
E
K
Y
A
L
----
E
L
L
E
M
T
G
I
E
C
V
Q
T
I
--
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
H
Y
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
8
PsiBlast_PDB
75.03
35%
-93
- C7 -
2B7N
2
NADC_HELPY
A:
[4-272]
-----------
R
T
F
L
E
R
A
----
L
K
E
D
L
----
G
H
G
-----
D
L
F
E
R
V
--
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
---
E
K
Y
A
L
----
E
L
L
E
M
T
G
I
E
C
V
Q
T
I
--
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
H
Y
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
49
PsiBlast_CBE
75.00
37%
-85
- C7 -
3L0G
2
?
C:
[30-294]
--------------
I
H
N
A
----
L
K
E
D
L
----
G
D
K
-----
G
D
I
T
T
-
N
S
I
L
I
N
E
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
---
I
P
I
----
L
E
E
V
F
N
M
N
K
E
H
V
K
Y
E
I
HK
K
D
G
D
I
T
G
K
N
S
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
--
K
V
K
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
-
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
K
K
A
V
D
I
V
N
G
K
S
---
V
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
50
PsiBlast_CBE
74.48
37%
-86
- C7 -
3L0G
2
?
B:
[30-294]
--------------
I
H
N
A
----
L
K
E
D
L
----
G
D
K
-----
G
D
I
T
T
-
N
S
I
L
I
N
E
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
---
I
P
I
----
L
E
E
V
F
N
M
N
K
E
H
V
K
Y
E
I
HK
K
D
G
D
I
T
G
K
N
S
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
--
K
V
K
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
K
-
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
K
K
A
V
D
I
V
N
G
K
S
---
V
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
46
PsiBlast_CBE
74.43
35%
-92
- C7 -
2B7N
2
NADC_HELPY
C:
[4-272]
-----------
R
T
F
L
E
R
A
----
L
K
E
D
L
----
G
H
G
-----
D
L
F
E
R
V
--
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
---
E
K
Y
A
L
----
E
L
L
E
M
T
G
I
E
C
V
Q
T
I
--
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
H
Y
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
47
PsiBlast_CBE
74.31
35%
-91
- C7 -
2B7N
2
NADC_HELPY
B:
[4-272]
-----------
R
T
F
L
E
R
A
----
L
K
E
D
L
----
G
H
G
-----
D
L
F
E
R
V
--
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
---
E
K
Y
A
L
----
E
L
L
E
M
T
G
I
E
C
V
Q
T
I
--
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
H
Y
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
9
PsiBlast_PDB
74.13
35%
-87
- C7 -
2B7P
2
NADC_HELPY
A:
[4-272]
-----------
R
T
F
L
E
R
A
----
L
K
E
D
L
----
G
H
G
-----
D
L
F
E
R
V
--
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
---
E
K
Y
A
L
----
E
L
L
E
M
T
G
I
E
C
V
Q
T
I
--
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
H
Y
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
101
HHSearch
73.94
40%
-105
- C7 -
3GNN
1
?
A:
[25-296]
------
F
D
A
A
I
A
R
N
V
A
D
A
----
L
A
E
D
V
----
G
-
S
-----
G
-----
L
-
V
P
D
G
A
P
R
R
A
R
V
I
V
R
E
D
A
V
L
C
G
---
V
P
W
F
D
A
V
V
R
-
A
V
-
D
P
S
I
E
V
D
W
R
H
--
R
E
G
D
R
M
S
A
D
S
T
V
C
E
L
R
G
P
A
R
A
L
L
T
A
E
R
N
A
L
N
F
L
Q
L
L
S
G
V
A
S
A
T
R
Q
Y
V
D
R
I
A
D
T
--
R
A
R
I
L
D
T
R
K
T
L
P
G
L
R
L
A
Q
K
Y
A
V
R
V
G
G
G
A
N
Q
-------------------
G
V
G
E
A
L
D
A
A
F
A
L
N
----
V
P
V
Q
I
E
V
E
T
L
D
Q
L
R
T
A
L
A
H
G
A
R
S
V
L
L
D
N
F
T
L
D
M
M
R
D
A
V
R
V
T
---
E
G
R
A
V
L
E
V
S
G
G
V
N
F
D
T
V
R
A
I
A
E
T
G
V
D
R
I
S
I
G
A
L
T
K
D
V
R
A
T
D
Y
S
M
R
I
43
PsiBlast_CBE
73.65
35%
-92
- C7 -
2B7Q
1
NADC_HELPY
B:
[4-272]
-----------
R
T
F
L
E
R
A
----
L
K
E
D
L
----
G
H
G
-----
D
L
F
E
R
V
--
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
---
E
K
Y
A
L
----
E
L
L
E
M
T
G
I
E
C
V
Q
T
I
--
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
H
Y
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
45
PsiBlast_CBE
73.64
35%
-94
- C7 -
2B7P
2
NADC_HELPY
B:
[4-272]
-----------
R
T
F
L
E
R
A
----
L
K
E
D
L
----
G
H
G
-----
D
L
F
E
R
V
--
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
---
E
K
Y
A
L
----
E
L
L
E
M
T
G
I
E
C
V
Q
T
I
--
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
H
Y
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
10
PsiBlast_PDB
73.43
35%
-93
- C7 -
2B7Q
1
NADC_HELPY
A:
[4-272]
-----------
R
T
F
L
E
R
A
----
L
K
E
D
L
----
G
H
G
-----
D
L
F
E
R
V
--
L
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
---
E
K
Y
A
L
----
E
L
L
E
M
T
G
I
E
C
V
Q
T
I
--
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
I
A
A
Y
R
D
A
H
Y
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
13
PsiBlast_PDB
70.89
41%
-99
- C7 -
3GNN
1
?
A:
[23-294]
--------
A
A
F
D
A
A
I
A
R
N
V
A
D
A
L
A
E
D
V
----
G
S
G
----------
L
--
V
P
D
G
A
P
R
R
A
R
V
I
V
R
E
D
A
V
L
C
G
V
P
W
F
D
A
V
V
R
A
V
D
P
S
I
E
V
D
W
-----
R
H
--
R
E
G
D
R
M
S
A
D
S
T
V
C
E
L
R
G
P
A
R
A
L
L
T
A
E
R
N
A
L
N
F
L
Q
L
L
S
G
V
A
S
A
T
R
Q
Y
V
D
R
I
A
D
T
--
R
A
R
I
L
D
T
R
K
T
L
P
G
L
R
L
A
Q
K
Y
A
V
R
V
G
G
G
A
N
Q
-------------------
G
V
G
E
A
L
D
A
A
F
A
L
N
----
V
P
V
Q
I
E
V
E
T
L
D
Q
L
R
T
A
L
A
H
G
A
R
S
V
L
L
D
N
F
T
L
D
M
M
R
D
A
V
R
V
T
E
G
R
A
---
V
L
E
V
S
G
G
V
N
F
D
T
V
R
A
I
A
E
T
G
V
D
R
I
S
I
G
A
L
T
K
D
V
R
A
T
D
Y
S
M
--
14
PsiBlast_PDB
70.35
31%
-90
- C7 -
4I9A
1
?
A:
[23-285]
----------------------
L
R
E
D
C
------------
P
G
L
N
P
V
A
L
V
T
G
A
A
P
S
Q
A
V
L
W
A
K
S
P
G
I
L
A
G
---
R
P
F
----
F
D
A
I
F
A
Q
V
N
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
K
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
M
L
A
R
C
S
G
V
A
S
A
A
A
T
A
V
E
T
A
R
G
T
GW
A
G
H
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
T
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
K
Q
A
V
Q
G
A
R
R
A
A
N
F
A
-
L
K
V
E
V
E
C
S
S
L
Q
E
A
L
E
A
A
E
A
G
A
D
L
V
L
L
D
N
F
R
P
E
E
L
H
P
T
A
A
A
L
K
A
Q
F
P
T
V
G
V
E
A
S
G
G
V
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
L
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
52
PsiBlast_CBE
69.83
31%
-88
- C7 -
4I9A
1
?
B:
[23-285]
----------------------
L
R
E
D
C
------------
P
G
L
N
P
V
A
L
V
T
G
A
A
P
S
Q
A
V
L
W
A
K
S
P
G
I
L
A
G
---
R
P
F
----
F
D
A
I
F
A
Q
V
N
C
Q
V
S
W
F
L
--
P
E
G
S
K
L
V
P
V
A
K
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
M
L
A
R
C
S
G
V
A
S
A
A
A
T
A
V
E
T
A
R
G
T
GW
A
G
H
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
T
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
K
Q
A
V
Q
G
A
R
R
A
A
N
F
A
-
L
K
V
E
V
E
C
S
S
L
Q
E
A
L
E
A
A
E
A
G
A
D
L
V
L
L
D
N
F
R
P
E
E
L
H
P
T
A
A
A
L
K
A
Q
F
P
T
V
G
V
E
A
S
G
G
V
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
L
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
51
PsiBlast_CBE
66.55
41%
-96
- C7 -
3GNN
1
?
B:
[23-294]
--------
A
A
F
D
A
A
I
A
R
N
V
A
D
A
L
A
E
D
V
----
G
S
G
-----
D
Q
----------
A
P
R
R
A
R
V
I
V
R
E
D
A
V
L
C
G
V
P
W
F
D
A
V
V
R
A
V
D
P
S
I
E
V
D
W
-----
R
H
--
R
E
G
D
R
M
S
A
D
S
T
V
C
E
L
R
G
P
A
R
A
L
L
T
A
E
R
N
A
L
N
F
L
Q
L
L
S
G
V
A
S
A
T
R
Q
Y
V
D
R
I
A
D
T
--
R
A
R
I
L
D
T
R
K
T
L
P
G
L
R
L
A
Q
K
Y
A
V
R
V
G
G
G
A
----------------------------------------
V
Q
I
E
V
E
T
L
D
Q
L
R
T
A
L
A
H
G
A
R
S
V
L
L
D
N
F
T
L
D
M
M
R
D
A
V
R
V
T
E
G
R
A
---
V
L
E
V
S
G
G
V
N
F
D
T
V
R
A
I
A
E
T
G
V
D
R
I
S
I
G
A
L
T
K
D
V
R
A
T
D
Y
S
M
--