@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1612: (2016-05-03 )
MSAAIAEPTSHDPDSGGHFGGPSGWGGRYVPEALMAVIEEVTAAYQKERVSQDFLDDLDRLQANYAGRPSPLYEATRLSQHAGSARIFLKREDLNHTGSHKINNVLGQALLARRMGKTRVIAETGAGQHGVATATACALLGLDCVIYMGGIDTARQALNVARMRLLGAEVVAVQTGSKTLKDAINEAFRDWVANADNTYYCFGTAAGPHPFPTMVRDFQRIIGMEARVQIQGQAGRLPDAVVACVGGGSNAIGIFHAFLDDPGVRLVGFEAAGDGVETGRHAATFTAGSPGAFHGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAWLKEAGRVDYRPITDSEAMDAFGLLCRMEGIIPAIESAHAVAGALKLGVELGRGAVIVVNLSGRGDKDVETAAKWFGLLGND
Atome Classification :
(82 SA)
.........10........20........30........40........50........60........70........80...-.....90........100.......110.......-120.......130.......140.......150.......160.......170.......180.....-..190...---....200.......210..---.....220.......230.......240.......250.......260.......270.......280.......290.........300.......310.......320.......330.......340.......350.......360.......370......-.-380........390-........400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSAAIAEPTSHDPDSGGHFGGPSGWGGR
Y
V
P
E
A
L
M
A
V
I
E
E
V
T
A
A
Y
Q
K
E
R
V
S
Q
D
F
L
D
D
L
D
R
L
Q
ANYAGRPSP
L
Y
E
A
T
R
L
S
QHAGS-
A
R
I
F
L
K
REDLNHTGS
H
K
I
N
N
V
L
G
Q
A
L
L
A
R
RMGK
T
R
-
V
I
A
ETGAGQH
G
V
A
T
A
T
A
C
A
L
L
GL
D
C
V
I
Y
MG
G
I
D
T
A
R
Q
A
L
N
V
A
R
M
R
LLG
A
E
V
V
A
V
QTG
S
K
T
L
K
D
A
I
N
E
A
-
F
R
D
W
VANA---DN
T
Y
Y
C
F
GTAAGPHP
F
P
T
M
---
V
R
D
F
Q
R
I
IGM
E
A
R
V
Q
I
QGQAGRL
P
D
A
V
V
A
C
VGGGSN
A
I
G
I
F
H
A
F
LDDPG
V
R
L
V
G
F
EAAGDGVETGR
H
A
A
T
FTAGSP--GAFHG
S
F
S
Y
L
L
QDEDG
Q
T
IESHSISAGLDYPGVGP
E
H
A
W
L
K
EAGRVDYRPIT
D
S
E
A
M
D
A
F
G
L
L
C
R
M
E
G
I
I
P
A
I
E
S
A
H
A
V
A
G
A
L
K
L
G
V
E-L-G-R
G
A
V
I
V
V
NLSG--RGD
K
D
V
E
T
A
A
K
W
F
G
LLGND
1
PsiBlast_PDB
90.07
100%
-113
- C3 -
2O2E
-
TRPB_MYCTU
A:
[29-404]
----------------------------
Y
V
P
E
A
L
M
A
V
I
E
E
V
T
A
A
Y
Q
K
E
R
V
S
Q
D
F
L
D
D
L
D
R
L
Q
A
N
Y
A
G
R
P
S
P
L
Y
E
A
T
R
L
S
Q
H
A
G
S
-
A
R
I
F
L
K
R
E
D
L
N
H
T
G
S
H
K
I
N
N
V
L
G
Q
A
L
L
A
R
R
M
G
K
T
R
-
V
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
T
A
C
A
L
L
G
L
D
C
V
I
Y
M
G
G
I
D
T
A
R
Q
A
L
N
V
A
R
M
R
L
L
G
A
E
V
V
A
V
Q
T
G
S
K
T
L
K
D
A
I
N
E
A
-
F
R
D
W
V
A
N
A
---
D
N
T
Y
Y
C
F
G
T
A
A
G
P
H
P
F
P
T
M
---
V
R
D
F
Q
R
I
I
G
M
E
A
R
V
Q
I
Q
G
Q
A
G
R
L
P
D
A
V
V
A
C
V
G
G
G
S
N
A
I
G
I
F
H
A
F
L
D
D
P
G
V
R
L
V
G
F
E
A
A
G
---------------------------------------------------------------
R
V
D
Y
R
P
I
T
D
S
E
A
M
D
A
F
G
L
L
C
R
M
E
G
I
I
P
A
I
E
S
A
H
A
V
A
G
A
L
K
L
G
V
E
-
L
-
G
-
R
G
A
V
I
V
V
N
L
S
G
--
R
G
D
K
D
V
E
T
A
A
K
W
F
------
2
PsiBlast_PDB
88.07
100%
-112
- C3 -
2O2J
-
TRPB_MYCTU
A:
[29-404]
----------------------------
Y
V
P
E
A
L
M
A
V
I
E
E
V
T
A
A
Y
Q
K
E
R
V
S
Q
D
F
L
D
D
L
D
R
L
Q
A
N
Y
A
G
R
P
S
P
L
Y
E
A
T
R
L
S
Q
H
A
G
S
-
A
R
I
F
L
K
R
E
D
L
N
H
T
G
S
H
K
I
N
N
V
L
G
Q
A
L
L
A
R
R
M
G
K
T
R
-
V
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
T
A
C
A
L
L
G
L
D
C
V
I
Y
M
G
G
I
D
T
A
R
Q
A
L
N
V
A
R
M
R
L
L
G
A
E
V
V
A
V
Q
T
G
S
K
T
L
K
D
A
I
N
E
A
-
F
R
D
W
V
A
N
A
---
D
N
T
Y
Y
C
F
G
T
A
A
G
P
H
P
F
P
T
M
---
V
R
D
F
Q
R
I
I
G
M
E
A
R
V
Q
I
Q
G
Q
A
G
R
L
P
D
A
V
V
A
C
V
G
G
G
S
N
A
I
G
I
F
H
A
F
L
D
D
P
G
V
R
L
V
G
F
E
A
A
G
---------------------------------------------------------------
R
V
D
Y
R
P
I
T
D
S
E
A
M
D
A
F
G
L
L
C
R
M
E
G
I
I
P
A
I
E
S
A
H
A
V
A
G
A
L
K
L
G
V
E
-
L
-
G
-
R
G
A
V
I
V
V
N
L
S
G
--
R
G
D
K
D
V
E
T
A
A
K
W
F
------
32
PsiBlast_CBE
87.17
58%
-84
- C3 -
5E0K
1
TRPB1_PYRFU
L:
[6-385]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
-
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
V
S
------
35
PsiBlast_CBE
87.02
58%
-84
- C3 -
5E0K
1
TRPB1_PYRFU
F:
[6-385]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
-
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
V
S
------
101
HHSearch
86.87
97%
-112
- C3 -
2O2E
-
TRPB_MYCTU
A:
[29-404]
----------------------------
Y
V
P
E
A
L
M
A
V
I
E
E
V
T
A
A
Y
Q
K
E
R
V
S
Q
D
F
L
D
D
L
D
R
L
Q
A
N
Y
A
G
R
P
S
P
L
Y
E
A
T
R
L
S
Q
H
A
G
S
-
A
R
I
F
L
K
R
E
D
L
N
H
T
G
S
H
K
I
N
N
V
L
G
Q
A
L
L
A
R
R
M
G
K
T
R
-
V
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
T
A
C
A
L
L
G
L
D
C
V
I
Y
M
G
G
I
D
T
A
R
Q
A
L
N
V
A
R
M
R
L
L
G
A
E
V
V
A
V
Q
T
G
S
K
T
L
K
D
A
I
N
E
A
F
R
D
W
V
A
N
A
----
D
N
T
Y
Y
C
F
G
T
A
---
A
G
P
H
P
F
P
T
M
V
R
D
F
Q
R
I
I
G
M
E
A
R
V
Q
I
Q
G
Q
A
G
R
L
P
D
A
V
V
A
C
V
G
G
G
S
N
A
I
G
I
F
H
A
F
L
D
D
P
G
V
R
L
V
G
F
E
A
A
G
---------------------------------------------------------------
R
V
D
Y
R
P
I
T
D
S
E
A
M
D
A
F
G
L
L
C
R
M
E
G
I
I
P
A
I
E
S
A
H
A
V
A
G
A
L
K
L
G
V
E
-
L
-
G
-
R
G
A
V
I
V
V
N
L
S
G
--
R
G
D
K
D
V
E
T
A
A
K
W
F
------
33
PsiBlast_CBE
86.79
58%
-81
- C3 -
5E0K
1
TRPB1_PYRFU
J:
[6-385]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
-
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
V
S
------
34
PsiBlast_CBE
86.67
58%
-81
- C3 -
5E0K
1
TRPB1_PYRFU
H:
[6-385]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
-
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
V
S
------
21
PsiBlast_CBE
86.16
58%
-77
- C3 -
5DW0
2
TRPB1_PYRFU
D:
[6-385]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
V
S
------
27
PsiBlast_CBE
86.11
58%
-78
- C3 -
1WDW
1
TRPB1_PYRFU
F:
[6-383]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
--------
26
PsiBlast_CBE
86.08
58%
-77
- C3 -
1WDW
1
TRPB1_PYRFU
H:
[6-383]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
--------
4
PsiBlast_PDB
85.87
58%
-77
- C3 -
1WDW
1
TRPB1_PYRFU
B:
[6-383]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
--------
31
PsiBlast_CBE
85.86
58%
-78
- C3 -
1V8Z
2
TRPB1_PYRFU
B:
[6-386]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
V
S
G
-----
3
PsiBlast_PDB
85.74
58%
-77
- C3 -
5DW0
2
TRPB1_PYRFU
A:
[6-386]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
V
S
G
-----
28
PsiBlast_CBE
85.70
58%
-77
- C3 -
1WDW
1
TRPB1_PYRFU
D:
[6-383]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
--------
25
PsiBlast_CBE
85.51
58%
-78
- C3 -
1WDW
1
TRPB1_PYRFU
J:
[6-383]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
--------
24
PsiBlast_CBE
85.39
58%
-77
- C3 -
1WDW
1
TRPB1_PYRFU
L:
[6-383]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
--------
23
PsiBlast_CBE
85.39
58%
-76
- C3 -
5DW0
2
TRPB1_PYRFU
B:
[6-385]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
V
S
------
30
PsiBlast_CBE
85.37
58%
-76
- C3 -
1V8Z
2
TRPB1_PYRFU
C:
[6-386]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
V
S
G
-----
5
PsiBlast_PDB
85.23
58%
-75
- C3 -
1V8Z
2
TRPB1_PYRFU
A:
[6-386]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
V
S
G
-----
22
PsiBlast_CBE
84.92
58%
-75
- C3 -
5DW0
2
TRPB1_PYRFU
C:
[6-385]
------------------------
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
S
R
T
L
K
D
A
I
N
E
A
-
L
R
D
W
V
A
T
F
---
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
---
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
P
F
V
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
G
K
H
S
A
S
L
N
A
G
Q
V
--
G
V
F
H
G
M
L
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
V
A
Y
A
M
K
L
A
K
E
-
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
--
R
G
D
K
D
L
D
I
V
L
K
V
S
------
52
PsiBlast_CBE
83.04
55%
-77
- C3 -
1A5A
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
92
PsiBlast_CBE
82.89
55%
-80
- C3 -
2J9Z
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
V
G
A
G
N
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
76
PsiBlast_CBE
82.28
55%
-77
- C3 -
1KFB
1
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
91
PsiBlast_CBE
82.24
55%
-75
* C3 *
1FUY
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
L
W
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
12
PsiBlast_PDB
82.17
55%
-77
- C3 -
2CLE
3
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
90
PsiBlast_CBE
82.04
55%
-79
- C3 -
1QOQ
1
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
A
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
16
PsiBlast_PDB
82.03
55%
-74
- C3 -
2CLF
4
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
70
PsiBlast_CBE
82.02
55%
-73
- C3 -
2CLL
3
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
18
PsiBlast_PDB
82.02
55%
-75
- C3 -
1TTQ
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
14
PsiBlast_PDB
81.99
55%
-74
- C3 -
2CLM
3
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
13
PsiBlast_PDB
81.82
55%
-74
- C3 -
2CLH
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
74
PsiBlast_CBE
81.79
55%
-73
- C3 -
1TJP
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
15
PsiBlast_PDB
81.78
55%
-72
- C3 -
2CLO
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
51
PsiBlast_CBE
81.72
55%
-79
- C3 -
1A5B
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
55
PsiBlast_CBE
81.69
55%
-75
- C3 -
4Y6G
4
?
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
66
PsiBlast_CBE
81.65
55%
-72
- C3 -
1KFC
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
57
PsiBlast_CBE
81.64
55%
-74
- C3 -
4WX2
6
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
59
PsiBlast_CBE
81.62
55%
-75
- C3 -
4HT3
20
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
20
PsiBlast_PDB
81.59
55%
-77
- C3 -
1BKS
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
50
PsiBlast_CBE
81.49
55%
-76
- C3 -
1BEU
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
87
PsiBlast_CBE
81.48
55%
-75
- C3 -
1UBS
3
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
49
PsiBlast_CBE
81.42
55%
-78
- C3 -
2DH5
4
TRPB_ECOLI
A:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
R
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
N
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
N
T
-
T
-
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
T
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
E
R
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
E
T
N
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
E
--
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
T
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
L
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
N
P
-
D
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
72
PsiBlast_CBE
81.37
55%
-75
- C3 -
2CLI
3
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
67
PsiBlast_CBE
81.34
55%
-75
- C3 -
1K8X
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
11
PsiBlast_PDB
81.34
55%
-75
- C3 -
1A50
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
121
Fugue
81.32
53%
-71
- C3 -
2TYS
2
TRPB_SALTY
B:
[3-397]
------------
T
L
L
N
P
Y
F
G
E
---
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
-
E
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
--
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
RG--
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
I
75
PsiBlast_CBE
81.30
55%
-73
- C3 -
1QOP
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
60
PsiBlast_CBE
81.17
55%
-72
- C3 -
4HPX
13
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
44
PsiBlast_CBE
81.17
55%
-73
- C3 -
1CW2
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
73
PsiBlast_CBE
81.15
55%
-72
- C3 -
1WBJ
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
71
PsiBlast_CBE
81.15
55%
-72
- C3 -
2CLK
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
80
PsiBlast_CBE
81.10
55%
-72
- C3 -
1KFE
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
89
PsiBlast_CBE
81.04
55%
-72
- C3 -
2J9Y
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
N
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
58
PsiBlast_CBE
81.00
55%
-70
- C3 -
4KKX
14
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
63
PsiBlast_CBE
80.92
55%
-73
- C3 -
2RH9
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
19
PsiBlast_PDB
80.89
55%
-72
- C3 -
1A5S
3
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
84
PsiBlast_CBE
80.86
55%
-71
- C3 -
3PR2
5
TRPB_SALTY
B:
[10-384]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
64
PsiBlast_CBE
80.79
55%
-74
- C3 -
1KFK
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
17
PsiBlast_PDB
80.76
55%
-78
- C3 -
1TTP
3
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
61
PsiBlast_CBE
80.75
55%
-71
- C3 -
4HPJ
10
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
54
PsiBlast_CBE
80.73
55%
-74
- C3 -
4ZQC
13
?
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
43
PsiBlast_CBE
80.71
55%
-74
- C3 -
1CX9
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
62
PsiBlast_CBE
80.63
55%
-70
- C3 -
4HN4
9
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
82
PsiBlast_CBE
80.60
55%
-72
- C3 -
1K8Y
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
P
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
79
PsiBlast_CBE
80.48
55%
-72
- C3 -
1K3U
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
45
PsiBlast_CBE
80.42
55%
-73
- C3 -
1C9D
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
65
PsiBlast_CBE
80.39
55%
-71
- C3 -
1KFJ
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
46
PsiBlast_CBE
80.35
55%
-71
- C3 -
1C8V
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
53
PsiBlast_CBE
80.24
55%
-73
- C3 -
5BW6
3
?
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
47
PsiBlast_CBE
80.21
55%
-71
- C3 -
1C29
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
88
PsiBlast_CBE
80.17
55%
-70
- C3 -
2TYS
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
83
PsiBlast_CBE
79.97
55%
-71
- C3 -
1K7X
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
P
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
56
PsiBlast_CBE
79.90
55%
-73
- C3 -
4XUG
4
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
69
PsiBlast_CBE
79.78
55%
-71
- C3 -
2J9X
7
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
68
PsiBlast_CBE
79.78
55%
-72
- C3 -
3CEP
4
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
77
PsiBlast_CBE
79.69
55%
-80
- C3 -
1K7F
1
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
--------------
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
78
PsiBlast_CBE
79.66
55%
-71
- C3 -
1K7E
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
81
PsiBlast_CBE
79.64
55%
-72
- C3 -
1K8Z
2
TRPB_SALTY
B:
[11-385]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
P
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
86
PsiBlast_CBE
79.60
55%
-73
- C3 -
2TRS
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
85
PsiBlast_CBE
79.35
55%
-70
- C3 -
2TSY
2
TRPB_SALTY
B:
[12-386]
------------------------
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
--
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
-
L
R
D
W
S
G
S
Y
---
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
-----------
102
HHSearch
79.27
58%
-97
- C3 -
4NEG
5
TRPB_BACAN
A:
[23-397]
-----------------------------
V
P
E
T
L
M
Q
S
V
L
E
L
E
E
A
Y
K
E
A
M
E
D
E
A
F
Q
K
E
L
N
H
Y
L
K
T
Y
V
G
R
E
T
P
L
Y
F
A
E
N
M
T
E
Y
C
G
G
-
A
K
I
Y
L
K
R
E
D
L
N
H
T
G
A
H
K
I
N
N
T
I
G
Q
A
L
L
A
V
R
M
G
K
K
K
-
V
V
A
E
T
G
A
G
Q
H
G
V
A
T
A
T
V
C
A
L
L
G
L
E
C
V
I
F
M
G
E
E
D
V
R
R
Q
K
L
N
V
F
R
M
E
L
L
G
A
K
V
E
S
V
A
A
G
--
T
L
K
D
A
V
N
E
A
-
L
R
Y
W
V
S
H
V
---
H
D
T
H
Y
I
M
G
S
V
L
G
P
H
P
F
P
Q
I
---
V
R
D
F
Q
S
V
I
G
N
E
T
K
K
Q
Y
E
A
L
E
G
K
L
P
E
A
V
V
A
C
I
G
G
G
S
N
A
M
G
M
F
Y
P
F
V
H
D
E
E
V
A
L
Y
G
V
E
A
A
G
-----------------------------------------------
D
Y
------
H
S
L
L
K
D
I
G
R
V
S
Y
H
S
I
T
D
D
E
A
L
E
A
F
Q
L
L
T
K
K
E
G
I
I
P
A
L
E
S
S
H
A
V
A
Y
A
L
K
L
A
P
Q
-
M
-
K
-
E
D
E
G
L
V
I
C
L
S
G
--
R
G
D
K
D
V
E
S
I
K
R
Y
M
------
104
HHSearch
79.22
51%
-72
- C3 -
4HT3
21
TRPB_SALTY
B:
[4-394]
-------------
L
L
N
P
Y
F
G
---
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
-
R
-
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
---
S
G
S
A
T
L
K
D
A
C
-
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
---
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
-
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
--
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
---