@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1617: (2016-05-03 )
MTRRGKIVCTLGPATQRDDLVRALVEAGMDVARMNFSHGDYDDHKVAYERVRVASDATGRAVGVLADLQGPKIRLGRFASGATHWAEGETVRITVGACEGSHDRVSTTYKRLAQDAVAGDRVLVDDGKVALVVDAVEGDDVVCTVVEGGPVSDNKGISLPGMNVTAPALSEKDIEDLTFALNLGVDMVALSFVRSPADVELVHEVMDRIGRRVPVIAKLEKPEAIDNLEAIVLAFDAVMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVEENSTAAPPLTHIPRTKRGVISYAARDIGERLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVPKMQSTDGMIRQVDKSLLELARYKRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDDV
Atome Classification :
(40 SA)
.........10........20........30........40........50......-.-.60-........70........80-.-.......90....-.---.-.---.--100.......110.......120.......130.....--.--.-140-.......150.......160.......170.....-.-.180.......190.......-200....-..-------.210-----.........220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.....--------.-------.340.------...-------...---350------........360.......370.......380.......390.......400.......410.--...----...------420.......430.......440--.........450-........460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTRR
G
K
I
V
C
TLGPAT
Q
R
D
D
L
V
R
A
L
V
E
AGM
D
V
A
R
M
NFSHGDYD
D
H
K
V
A
Y
E
R
V
RVASDA-T-G
R
A
-
V
G
V
L
ADLQGP
K
I
R
L
G
RFASG-A-THWAEG
E
T
V
R
I
T
V
-
G
---A-C---E--GSH
D
R
V
S
T
T
Y
K
R
L
A
Q
D
AVAG
D
R
V
L
VDDG
K
V
A
L
V
V
D
AVE--G--D-
D
V
V
-
C
T
V
VEGGPVSDNKGISLPGMNVTAPALSEK
D
I
E
D
L
-
T
-
F
A
L
NL
G
V
D
M
V
A
L
S
F
VRSPA
D
V
-
E
L
V
H
E
V
M
-
D
R
-------IG-------RRV
P
V
I
A
KLEKPEAI
D
N
L
E
A
I
V
L
A
F
D
A
V
M
V
ARGDLGVELP
L
E
EVP
L
V
Q
K
R
A
I
Q
M
A
RENAK
P
V
I
V
A
T
Q
M
L
D
S
M
I
ENSRPTRA
E
A
S
D
V
A
N
A
V
LDGA
D
A
L
M
LSGETSVGKY
P
L
A
A
V
R
T
M
S
R
I
I
C
A
VEENS--------T-------AAPPL------THI-------PRT---K
R
-------
G
V
I
S
Y
A
A
R
D
I
G
E
R
L
D
A
K
A
L
V
A
FTQS
G
D
T
V
R
R
L
A
R
LHTPLP
L
L
A
FTA
W
P
E
V
R
S
Q
L
A
MTWGT
E
T
--
F
I
V
----PKM------QST
D
G
M
I
R
Q
V
D
K
S
L
L
E
L
A
RYK----RG
D
L
V
V
I
V
AGA--PPGTVGS
T
N
L
I
H
V
H
RIGEDDV
33
PsiBlast_CBE
95.02
40%
-97
- C8 -
4YNG
2
KPYK1_ECOLI
D:
[2-468]
--
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
-
T
-
G
K
T
-
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
-
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D
K
---
S
-
V
---
I
--
G
N
S
E
M
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
--
G
--
N
-
K
V
I
-
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
-
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
-
A
H
-------
G
G
-------
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
--------
N
-------
S
R
L
--------------------
K
---
L
R
I
T
-----
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
--
Q
L
V
----
K
E
I
------
T
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
----
K
G
D
V
V
V
M
V
S
G
A
LV
P
S
G
T
---
T
N
T
A
S
V
H
-------
35
PsiBlast_CBE
94.92
40%
-98
- C8 -
4YNG
2
KPYK1_ECOLI
B:
[2-468]
--
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
-
T
-
G
K
T
-
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
-
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D
K
---
S
-
V
---
I
--
G
N
S
E
M
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
--
G
--
N
-
K
V
I
-
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
-
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
-
A
H
-------
G
G
-------
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
--------
N
-------
S
R
L
E
-------------------
K
---
L
R
I
T
-----
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
--
Q
L
V
----
K
E
I
------
T
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
----
K
G
D
V
V
V
M
V
S
G
A
LV
P
S
G
T
---
T
N
T
A
S
V
H
-------
34
PsiBlast_CBE
94.90
40%
-95
- C8 -
4YNG
1
KPYK1_ECOLI
C:
[2-468]
--
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
-
T
-
G
K
T
-
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
-
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D
K
---
S
-
V
---
I
--
G
N
S
E
M
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
--
G
--
N
-
K
V
I
-
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
-
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
-
A
H
-------
G
G
-------
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
--------
N
-------
S
R
L
E
F
------
N
----------
R
K
---
L
R
I
T
-----
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
--
Q
L
V
----
K
E
I
------
T
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
----
K
G
D
V
V
V
M
V
S
G
A
LV
P
S
G
T
---
T
N
T
A
S
V
H
-------
31
PsiBlast_CBE
94.64
40%
-98
- C8 -
4YNG
2
KPYK1_ECOLI
F:
[2-468]
--
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
-
T
-
G
K
T
-
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
-
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D
K
---
S
-
V
---
I
--
G
N
S
E
M
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
--
G
--
N
-
K
V
I
-
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
-
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
-
A
H
-------
G
G
-------
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
--------
N
-------
S
R
L
E
F
------------------
K
---
L
R
IT-----
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
--
Q
L
V
----
K
E
I
------
T
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
----
K
G
D
V
V
V
M
V
S
G
A
LV
P
S
G
T
---
T
N
T
A
S
V
H
-------
144
HHSearch
94.56
39%
-100
- C8 -
3T05
1
KPYK_STAAR
A:
[22-495]
-
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
-
L
-
D
K
I
-
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
-
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
-
N
---
E
-
V
---
E
--
G
T
P
E
K
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
--
H
AK
K
-
E
V
K
-
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
-
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
-
L
E
I
R
E
I
L
-
E
E
-------
Q
K
-------
A
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
--------
D
-------
Y
K
K
L
L
S
D
R
T
--
K
L
V
-------
E
T
S
---
L
V
-------
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
--
V
V
K
----
K
G
R
------
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
----
N
G
D
L
I
I
I
T
A
G
V
--
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
---
159
Fugue
94.23
40%
-99
- C8 -
1PKY
-
KPYK1_ECOLI
A:
[1-470]
-
M
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
T
--
G
K
T
-
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
-
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
-
D
---
K
-
S
V
--
I
--
G
N
S
E
M
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
-----
G
N
K
V
I
-
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
-
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
-
I
E
I
R
E
H
L
K
A
H
-------
G
G
-------
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
M
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
--------
N
-------
S
--
R
L
------
E
------------KLR
I
T
-------
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
--
Q
L
V
KEIT----------
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
----
K
G
D
V
V
V
M
V
S
G
A
--
L
V
P
S
-
G
T
T
N
T
A
S
V
H
V
L
-----
6
PsiBlast_PDB
94.18
39%
-97
- C8 -
1PKY
-
KPYK1_ECOLI
A:
[2-468]
--
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
-
T
-
G
K
T
-
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
-
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D
K
---
S
-
V
---
I
--
G
N
S
E
M
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
--
G
--
N
-
K
V
I
-
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
-
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
-
A
H
-------
G
G
-------
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
M
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
--------
N
-------
S
R
L
E
-------------------
K
---
L
R
I
T
-----
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
--
Q
L
V
----
K
E
I
------
T
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
----
K
G
D
V
V
V
M
V
S
G
A
LV
P
S
G
T
---
T
N
T
A
S
V
H
-------
5
PsiBlast_PDB
94.09
40%
-92
- C8 -
4YNG
1
KPYK1_ECOLI
A:
[2-468]
--
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
-
T
-
G
K
T
-
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
-
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D
K
---
S
-
V
---
I
--
G
N
S
E
M
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
--
G
--
N
-
K
V
I
-
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
-
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
-
A
H
-------
G
G
-------
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
--------
N
-------
S
R
L
E
F
------------------
K
---
L
R
I
T
-----
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
--
Q
L
V
----
K
E
I
------
T
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
----
K
G
D
V
V
V
M
V
S
G
A
LV
P
S
G
T
---
T
N
T
A
S
V
H
-------
30
PsiBlast_CBE
94.01
40%
-97
- C8 -
4YNG
1
KPYK1_ECOLI
G:
[2-468]
--
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
-
T
-
G
K
T
-
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
-
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D
K
---
S
-
V
---
I
--
G
N
S
E
M
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
--
G
--
N
-
K
V
I
-
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
-
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
-
A
H
-------
G
G
-------
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
--------
N
-------
S
R
L
E
F
-----------------------
R
IT-----
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
--
Q
L
V
----
K
E
I
------
T
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
----
K
G
D
V
V
V
M
V
S
G
A
LV
P
S
G
T
---
T
N
T
A
S
V
H
-------
32
PsiBlast_CBE
93.78
40%
-94
- C8 -
4YNG
1
KPYK1_ECOLI
E:
[2-468]
--
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
-
T
-
G
K
T
-
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
-
N
D
V
S
L
K
A
G
Q
T
F
T
F
T
T
D
K
---
S
-
V
---
I
--
G
N
S
E
M
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
--
G
--
N
-
K
V
I
-
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
-
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
-
A
H
-------
G
G
-------
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
--------
N
-------
S
R
L
E
F
------
N
N
D
-------
N
R
K
---
L
R
I
T
-----
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
--
Q
L
V
----
K
E
I
------
T
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
S
G
L
A
H
----
K
G
D
V
V
V
M
V
S
G
A
LV
P
S
G
T
---
T
N
T
A
S
V
H
-------
146
HHSearch
93.61
43%
-91
- C8 -
2E28
1
KPYK_GEOSE
A:
[1-476]
M
K
R
K
T
K
I
V
S
T
I
G
P
A
S
E
S
V
D
K
L
V
Q
L
M
E
A
G
M
N
V
A
R
L
N
F
S
H
G
D
H
E
E
H
G
R
R
I
A
N
I
R
E
A
A
K
R
-
T
-
G
R
T
-
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
E
N
G
-
A
-
I
E
L
K
E
G
S
K
L
V
I
S
M
-
S
---
E
-
V
---
L
--
G
T
P
E
K
I
S
V
T
Y
P
S
L
I
D
D
V
S
V
G
A
K
I
L
L
D
D
G
L
I
S
L
E
V
N
A
V
D
--
K
QA
G
-
E
I
V
-
T
T
V
L
N
G
G
V
L
K
N
K
K
G
V
N
V
P
G
V
K
V
N
L
P
G
I
T
E
K
D
R
A
D
I
-
L
-
F
G
I
R
Q
G
I
D
F
I
A
A
S
F
V
R
R
A
S
D
V
-
L
E
I
R
E
L
L
-
E
A
-------
H
D
A------
L
H
I
Q
I
I
A
K
I
E
N
E
E
G
V
A
N
I
D
E
I
L
E
A
A
D
G
L
M
V
A
R
G
D
L
G
V
E
I
P
A
E
E
V
P
L
I
Q
K
L
L
I
K
K
S
N
M
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
P
T
R
A
E
A
S
D
V
A
N
A
I
F
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
Q
Y
P
V
E
A
V
K
T
M
H
Q
I
A
L
R
T
E
Q
A
L
--------
E
-------
H
R
D
I
L
S
Q
R
T
--
K
E
S
-------
Q
T
T
---
I
T
-------
D
A
I
G
Q
S
V
A
H
T
A
L
N
L
D
V
A
A
I
V
T
P
T
V
S
G
K
T
P
Q
M
V
A
K
Y
R
P
K
A
P
I
I
A
V
T
S
N
E
A
V
S
R
R
L
A
L
V
W
G
V
Y
T
--
K
E
A
----
P
H
V
------
N
T
T
D
E
M
L
D
V
A
V
D
A
A
V
R
S
G
L
V
K
----
H
G
D
L
V
V
I
T
A
G
V
--
P
V
G
E
T
G
S
T
N
L
M
K
V
H
V
I
S
D
---
27
PsiBlast_CBE
93.47
38%
-99
- C8 -
3T05
1
KPYK_STAAR
D:
[22-496]
-
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
-
L
-
D
K
I
-
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
-
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
-
N
---
E
-
V
---
E
--
G
T
P
E
K
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
HA
K
--
K
-
E
V
K
-
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
-
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
-
L
E
I
R
E
I
L
-
E
E
-------
Q
K
-------
A
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
--------
D
-------
Y
K
K
L
L
------
S
D
---------
R
T
---
K
L
VETSLV-
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
--
V
V
K
----
K
G
R
------
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
----
N
G
D
L
I
I
I
T
A
G
V
--
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
--
28
PsiBlast_CBE
93.28
38%
-99
- C8 -
3T05
1
KPYK_STAAR
C:
[22-496]
-
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
-
L
-
D
K
I
-
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
-
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
-
N
---
E
-
V
---
E
--
G
T
P
E
K
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
HA
K
--
K
-
E
V
K
-
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
-
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
-
L
E
I
R
E
I
L
-
E
E
-------
Q
K
-------
A
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
--------
D
-------
Y
K
K
L
L
------
S
D
---------
R
T
---
K
L
VETSLV-
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
--
V
V
K
----
K
G
R
------
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
----
N
G
D
L
I
I
I
T
A
G
V
--
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
--
2
PsiBlast_PDB
93.26
38%
-100
- C8 -
3T05
1
KPYK_STAAR
A:
[22-496]
-
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
-
L
-
D
K
I
-
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
-
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
-
N
---
E
-
V
---
E
--
G
T
P
E
K
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
HA
K
--
K
-
E
V
K
-
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
-
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
-
L
E
I
R
E
I
L
-
E
E
-------
Q
K
-------
A
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
--------
D
-------
Y
K
K
L
L
------
S
D
---------
R
T
---
K
L
V
E
T
S
L
V
-
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
--
V
V
K
----
K
G
R
------
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
----
N
G
D
L
I
I
I
T
A
G
V
--
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
--
25
PsiBlast_CBE
93.12
38%
-98
- C8 -
3T07
2
KPYK_STAAR
C:
[22-496]
-
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
-
L
-
D
K
I
-
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
-
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
-
N
---
E
-
V
---
E
--
G
T
P
E
K
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
HA
K
--
K
-
E
V
K
-
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
-
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
-
L
E
I
R
E
I
L
-
E
E
-------
Q
K
-------
A
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
--------
D
-------
Y
K
K
L
L
------
S
D
---------
R
T
---
K
L
VETSLV-
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
--
V
V
K
----
K
G
R
------
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
----
N
G
D
L
I
I
I
T
A
G
V
--
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
--
29
PsiBlast_CBE
93.03
38%
-99
- C8 -
3T05
1
KPYK_STAAR
B:
[22-496]
-
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
-
L
-
D
K
I
-
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
-
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
-
N
---
E
-
V
---
E
--
G
T
P
E
K
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
HA
K
--
K
-
E
V
K
-
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
-
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
-
L
E
I
R
E
I
L
-
E
E
-------
Q
K
-------
A
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
--------
D
-------
Y
K
K
L
L
------
S
D
---------
R
T
---
K
L
VETSLV-
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
--
V
V
K
----
K
G
R
------
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
----
N
G
D
L
I
I
I
T
A
G
V
--
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
--
24
PsiBlast_CBE
92.92
38%
-98
- C8 -
3T07
2
KPYK_STAAR
D:
[22-496]
-
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
-
L
-
D
K
I
-
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
-
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
-
N
---
E
-
V
---
E
--
G
T
P
E
K
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
HA
K
--
K
-
E
V
K
-
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
-
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
-
L
E
I
R
E
I
L
-
E
E
-------
Q
K
-------
A
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
--------
D
-------
Y
K
K
L
L
------
S
D
---------
R
T
---
K
L
VETSLV-
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
--
V
V
K
----
K
G
R
------
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
----
N
G
D
L
I
I
I
T
A
G
V
--
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
--
22
PsiBlast_CBE
92.88
38%
-98
- C8 -
3T0T
2
KPYK_STAAR
C:
[22-496]
-
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
-
L
-
D
K
I
-
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
-
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
-
N
---
E
-
V
---
E
--
G
T
P
E
K
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
HA
K
--
K
-
E
V
K
-
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
-
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
-
L
E
I
R
E
I
L
-
E
E
-------
Q
K
-------
A
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
--------
D
-------
Y
K
K
L
L
------
S
D
---------
R
T
---
K
L
VETSLV-
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
--
V
V
K
----
K
G
R
------
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
----
N
G
D
L
I
I
I
T
A
G
V
--
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
--
21
PsiBlast_CBE
92.72
38%
-98
- C8 -
3T0T
2
KPYK_STAAR
D:
[22-496]
-
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
-
L
-
D
K
I
-
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
-
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
-
N
---
E
-
V
---
E
--
G
T
P
E
K
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
HA
K
--
K
-
E
V
K
-
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
-
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
-
L
E
I
R
E
I
L
-
E
E
-------
Q
K
-------
A
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
--------
D
-------
Y
K
K
L
L
------
S
D
---------
R
T
---
K
L
VETSLV-
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
--
V
V
K
----
K
G
R
------
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
----
N
G
D
L
I
I
I
T
A
G
V
--
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
--
4
PsiBlast_PDB
92.48
38%
-98
- C8 -
3T0T
2
KPYK_STAAR
A:
[22-496]
-
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
-
L
-
D
K
I
-
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
-
I
-
I
E
L
E
R
G
N
E
V
I
V
S
M
-
N
---
E
-
V
---
E
--
G
T
P
E
K
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
HA
K
--
K
-
E
V
K
-
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
-
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
-
L
E
I
R
E
I
L
-
E
E
-------
Q
K
-------
A
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
--------
D
-------
Y
K
K
L
L
------
S
D
---------
R
T
---
K
L
V
ETSLV-
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
--
V
V
K
----
K
G
R
------
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
T
G
R
V
T
----
N
G
D
L
I
I
I
T
A
G
V
--
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
--
101
PsiBlast_CBE
90.56
34%
-98
* C8 *
3MA8
2
?
B:
[52-532]
--
R
K
T
Q
I
I
C
T
I
G
P
S
C
N
N
V
E
S
L
I
G
L
I
D
K
G
M
S
V
A
R
L
N
F
S
H
G
D
H
E
S
H
F
K
T
L
Q
N
I
R
E
A
A
K
A
-
R
-
P
H
S
T
V
G
I
M
L
D
T
K
G
P
E
I
R
T
G
M
L
E
G
G
-
K
P
I
E
L
K
A
G
Q
T
L
K
I
T
T
-
D
Y--
S
-
M
---
L
--
G
N
S
E
C
I
S
C
S
Y
S
L
L
P
K
S
V
Q
I
G
S
T
V
L
I
A
D
G
S
L
S
T
Q
V
L
E
I
G
--
D
--
D
-
F
I
V
-
C
K
V
L
N
S
V
T
I
G
E
R
K
N
M
N
L
P
G
C
K
V
H
L
P
I
I
G
D
K
D
R
H
D
I
-
V
D
F
A
L
K
Y
N
L
D
F
I
A
L
S
F
V
Q
N
G
A
D
V
-
Q
L
C
R
Q
I
I
-
S
E
N
TQYSNG
I
P
-------
S
S
I
K
I
I
S
K
I
E
N
L
E
G
V
I
N
F
D
S
I
C
S
E
S
D
G
I
M
V
A
R
G
D
L
G
M
E
I
P
P
E
K
I
F
V
A
Q
K
C
M
I
S
K
C
N
V
A
G
K
P
V
V
T
A
T
Q
M
L
E
S
M
I
K
S
N
R
P
T
R
A
E
M
T
D
V
A
N
A
V
L
D
G
S
D
C
V
M
L
S
G
E
T
A
N
G
A
F
P
F
D
A
V
N
V
M
S
R
-
V
C
A
Q
A
E
T
C
--------
I
-------
D
Y
P
V
L
------
Y
H
A
I
H
S
S
VPK
P
V
A
---
V
P
-------
E
A
I
A
C
S
A
V
E
S
A
H
D
V
N
A
K
L
I
I
T
I
T
E
T
G
N
T
A
R
L
I
S
K
Y
R
P
S
Q
T
I
I
A
C
T
A
K
P
E
V
A
R
G
L
K
I
A
R
G
V
K
T
--
Y
V
L
----
N
S
I
------
H
H
S
E
V
V
I
S
N
A
L
A
L
A
K
E
E
S
L
I
E
----
S
G
D
F
A
I
A
V
H
G
V
--
K
------
C
N
L
M
K
I
V
R
------
141
HHSearch
90.30
35%
-103
- C8 -
4DRS
7
?
A:
[42-526]
T
Q
R
K
T
Q
I
I
C
T
I
G
P
S
C
N
N
V
E
S
L
I
G
L
I
D
K
G
M
S
V
A
R
L
N
F
S
H
G
D
H
E
S
H
F
K
T
L
Q
N
I
R
E
A
A
K
A
-
R
P
H
S
T
-
V
G
I
M
L
D
T
K
G
P
E
I
R
T
G
M
L
E
G
G
K
P
-
I
E
L
K
A
G
Q
T
L
K
I
T
T
-
D
---
Y
S
M
---
L
--
G
N
S
E
C
I
S
C
S
Y
S
L
L
P
K
S
V
Q
I
G
S
T
V
L
I
A
D
G
S
L
S
T
Q
V
L
E
I
G
--
D
--
D
-
F
I
V
-
C
K
V
L
N
S
V
T
I
G
E
R
K
N
M
N
L
P
G
C
K
V
H
L
P
I
I
G
D
K
D
R
H
D
I
V
D
-
F
A
L
K
Y
N
L
D
F
I
A
L
S
F
V
Q
N
G
A
D
V
-
Q
L
C
R
Q
I
I
-
S
E
-------
N
T
QYSNGIP
S
S
I
K
I
I
S
K
I
E
N
L
E
G
V
I
N
F
D
S
I
C
S
E
S
D
G
I
M
V
A
R
G
D
L
G
M
E
I
P
P
E
K
I
F
V
A
Q
K
C
M
I
S
K
C
N
V
A
G
K
P
V
V
T
A
T
Q
M
L
E
S
M
I
K
S
N
R
P
T
R
A
E
M
T
D
V
A
N
A
V
L
D
G
S
D
C
V
M
L
S
G
E
T
A
N
G
A
F
P
F
D
A
V
N
V
M
S
R
V
C
A
Q
A
E
T
C
I
--------
D
-------
Y
P
V
L
Y
H
A
I
H
S
S
V
P
K
-------
P
V
A
---
V
P
-------
E
A
I
A
C
S
A
V
E
S
A
H
D
V
N
A
K
L
I
I
T
I
T
E
T
G
N
T
A
R
L
I
S
K
Y
R
P
S
Q
T
I
I
A
C
T
A
K
P
E
V
A
R
G
L
K
I
A
R
G
V
K
T
--
Y
V
L
----
N
S
I
------
H
H
S
E
V
V
I
S
N
A
L
A
L
A
K
E
E
S
L
I
E
----
S
G
D
F
A
I
A
V
H
------------
N
L
M
K
I
V
R
C
P
----
99
PsiBlast_CBE
90.15
34%
-102
- C8 -
4DRS
7
?
B:
[44-524]
--
R
K
T
Q
I
I
C
T
I
G
P
S
C
N
N
V
E
S
L
I
G
L
I
D
K
G
M
S
V
A
R
L
N
F
S
H
G
D
H
E
S
H
F
K
T
L
Q
N
I
R
E
A
A
K
A
-
R
-
P
H
S
T
V
G
I
M
L
D
T
K
G
P
E
I
R
T
G
M
L
E
G
G
-
K
P
I
E
L
K
A
G
Q
T
L
K
I
T
T
-
D
Y--
S
-
M
---
L
--
G
N
S
E
C
I
S
C
S
Y
S
L
L
P
K
S
V
Q
I
G
S
T
V
L
I
A
D
G
S
L
S
T
Q
V
L
E
I
G
--
D
--
D
-
F
I
V
-
C
K
V
L
N
S
V
T
I
G
E
R
K
N
M
N
L
P
G
C
K
V
H
L
P
I
I
G
D
K
D
R
H
D
I
-
V
D
F
A
L
K
Y
N
L
D
F
I
A
L
S
F
V
Q
N
G
A
D
V
-
Q
L
C
R
Q
I
I
-
S
E
NTQYSNG
I
P
-------
S
S
I
K
I
I
S
K
I
E
N
L
E
G
V
I
N
F
D
S
I
C
S
E
S
D
G
I
M
V
A
R
G
D
L
G
M
E
I
P
P
E
K
I
F
V
A
Q
K
C
M
I
S
K
C
N
V
A
G
K
P
V
V
T
A
T
Q
M
L
E
S
M
I
K
S
N
R
P
T
R
A
E
M
T
D
V
A
N
A
V
L
D
G
S
D
C
V
M
L
S
G
E
T
A
N
G
A
F
P
F
D
A
V
N
V
M
S
R
-
V
C
A
Q
A
E
T
C
--------
I
-------
D
Y
P
V
L
------
Y
H
A
IHSSVPK
P
V
A
---
V
P
-------
E
A
I
A
C
S
A
V
E
S
A
H
D
V
N
A
K
L
I
I
T
I
T
E
T
G
N
T
A
R
L
I
S
K
Y
R
P
S
Q
T
I
I
A
C
T
A
K
P
E
V
A
R
G
L
K
I
A
R
G
V
K
T
--
Y
V
L
----
N
S
I
------
H
H
S
E
V
V
I
S
N
A
L
A
L
A
K
E
E
S
L
I
E
----
S
G
D
F
A
I
A
V
H
------------
N
L
M
K
I
V
R
------
100
PsiBlast_CBE
89.32
34%
-102
- C8 -
4DRS
7
?
A:
[44-524]
--
R
K
T
Q
I
I
C
T
I
G
P
S
C
N
N
V
E
S
L
I
G
L
I
D
K
G
M
S
V
A
R
L
N
F
S
H
G
D
H
E
S
H
F
K
T
L
Q
N
I
R
E
A
A
K
A
-
R
-
P
H
S
T
V
G
I
M
L
D
T
K
G
P
E
I
R
T
G
M
L
E
G
G
-
K
P
I
E
L
K
A
G
Q
T
L
K
I
T
T
-
D
Y--
S
-
M
---
L
--
G
N
S
E
C
I
S
C
S
Y
S
L
L
P
K
S
V
Q
I
G
S
T
V
L
I
A
D
G
S
L
S
T
Q
V
L
E
I
G
--
D
--
D
-
F
I
V
-
C
K
V
L
N
S
V
T
I
G
E
R
K
N
M
N
L
P
G
C
K
V
H
L
P
I
I
G
D
K
D
R
H
D
I
-
V
D
F
A
L
K
Y
N
L
D
F
I
A
L
S
F
V
Q
N
G
A
D
V
-
Q
L
C
R
Q
I
I
-
S
E
N
TQYSNG
I
P
-------
S
S
I
K
I
I
S
K
I
E
N
L
E
G
V
I
N
F
D
S
I
C
S
E
S
D
G
I
M
V
A
R
G
D
L
G
M
E
I
P
P
E
K
I
F
V
A
Q
K
C
M
I
S
K
C
N
V
A
G
K
P
V
V
T
A
T
Q
M
L
E
S
M
I
K
S
N
R
P
T
R
A
E
M
T
D
V
A
N
A
V
L
D
G
S
D
C
V
M
L
S
G
E
T
A
N
G
A
F
P
F
D
A
V
N
V
M
S
R
-
V
C
A
Q
A
E
T
C
--------
I
-------
D
Y
P
V
L
------
Y
H
A
I
H
S
S
VPK
P
V
A
---
V
P
-------
E
A
I
A
C
S
A
V
E
S
A
H
D
V
N
A
K
L
I
I
T
I
T
E
T
G
N
T
A
R
L
I
S
K
Y
R
P
S
Q
T
I
I
A
C
T
A
K
P
E
V
A
R
G
L
K
I
A
R
G
V
K
T
--
Y
V
L
----
N
S
I
------
H
H
S
E
V
V
I
S
N
A
L
A
L
A
K
E
E
S
L
I
E
----
S
G
D
F
A
I
A
V
H
------------
N
L
M
K
I
V
R
------
140
HHSearch
89.12
35%
-92
- C8 -
4KCT
5
KPYK1_TRYBB
B:
[18-499]
K
H
R
A
N
R
I
V
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
N
L
M
K
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
V
R
A
A
A
A
E
-
L
-
G
L
H
-
I
G
I
A
L
D
T
K
G
P
E
I
R
T
G
L
F
K
D
G
-
E
-
V
S
F
A
P
G
D
I
V
C
V
T
T
-
D
---
P
-
A
YEK
V
--
G
T
K
E
K
F
Y
I
D
Y
P
Q
L
T
N
A
V
R
P
G
G
S
I
Y
V
D
D
G
V
M
T
L
R
V
V
S
K
E
D-
D
--
R
-
T
L
K
-
C
H
V
N
N
H
H
R
L
T
D
R
R
G
I
N
L
P
G
C
E
V
D
L
P
A
V
S
E
K
D
R
K
D
L
-
E
-
F
G
V
A
Q
G
V
D
M
I
F
A
S
F
I
R
T
A
E
Q
V
-
R
E
V
R
A
A
L
-
G
E
-------
K
G
-------
K
D
I
L
I
I
S
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
A
S
N
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
C
V
A
Q
M
C
I
I
S
K
C
N
V
V
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
S
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
L
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
I
C
V
E
A
Q
S
A
T
--------
H
-------
D
T
V
M
F
NSIKNL
Q
K
I
-------
P
M
C
---
P
E
-------
E
A
V
C
S
S
A
V
A
S
A
F
E
V
Q
A
K
A
M
L
V
L
S
N
T
G
R
S
A
R
L
I
S
K
Y
R
P
N
C
P
I
I
C
V
T
T
R
L
Q
T
C
R
Q
L
N
V
T
R
S
V
V
S
--
V
F
Y
----
D
A
A
KSGED-
K
D
K
E
K
R
V
K
L
G
L
D
F
A
K
K
E
K
Y
A
S
----
T
G
D
V
V
V
V
V
H
A
D
--
H
S
V
-
K
G
Y
P
N
Q
T
R
L
I
Y
L
P
----
102
PsiBlast_CBE
88.87
34%
-96
- C8 -
3MA8
2
?
A:
[52-532]
--
R
K
T
Q
I
I
C
T
I
G
P
S
C
N
N
V
E
S
L
I
G
L
I
D
K
G
M
S
V
A
R
L
N
F
S
H
G
D
H
E
S
H
F
K
T
L
Q
N
I
R
E
A
A
K
A
-
R
-
P
H
S
T
V
G
I
M
L
D
T
K
G
P
E
I
R
T
G
M
L
E
G
G
-
K
P
I
E
L
K
A
G
Q
--
K
I
T
T
-
D
Y--
S
-
M
---
L
--
G
N
S
E
C
I
S
C
S
Y
S
L
L
P
K
S
V
Q
I
G
S
T
V
L
I
A
D
G
S
L
S
T
Q
V
L
E
I
G
--
D
--
D
-
F
I
V
-
C
K
V
L
N
S
V
T
I
G
E
R
K
N
M
N
L
P
G
C
K
V
H
L
P
I
I
G
D
K
D
R
H
D
I
-
V
D
F
A
L
K
Y
N
L
D
F
I
A
L
S
F
V
Q
N
G
A
D
V
-
Q
L
C
R
Q
I
I
-
S
E
N
TQYSNG
I
P
-------
S
S
I
K
I
I
S
K
I
E
N
L
E
G
V
I
N
F
D
S
I
C
S
E
S
D
G
I
M
V
A
R
G
D
L
G
M
E
I
P
P
E
K
I
F
V
A
Q
K
C
M
I
S
K
C
N
V
A
G
K
P
V
V
T
A
T
Q
M
L
E
S
M
I
K
S
N
R
P
T
R
A
E
M
T
D
V
A
N
A
V
L
D
G
S
D
C
V
M
L
S
G
E
T
A
N
G
A
F
P
F
D
A
V
N
V
M
S
R
-
V
C
A
Q
A
E
T
C
--------
I
-------
D
Y
P
V
L
------
Y
H
A
I
H
S
S
VPK
P
V
A
---
V
P
-------
E
A
I
A
C
S
A
V
E
S
A
H
D
V
N
A
K
L
I
I
T
I
T
E
T
G
N
T
A
R
L
I
S
K
Y
R
P
S
Q
T
I
I
A
C
T
A
K
P
E
V
A
R
G
L
K
I
A
R
G
V
K
T
--
Y
V
L
----
N
S
I
------
H
H
S
E
V
V
I
S
N
A
L
A
L
A
K
E
E
S
L
I
E
----
S
G
D
F
A
I
A
V
H
G
V
---------
C
N
L
M
K
I
V
R
------
143
HHSearch
86.91
35%
-93
- C8 -
1A3W
4
KPYK1_YEAST
A:
[17-500]
D
L
R
R
T
S
I
I
G
T
I
G
P
K
T
N
N
P
E
T
L
V
A
L
R
K
A
G
L
N
I
V
R
M
N
F
S
H
G
S
Y
E
Y
H
K
S
V
I
D
N
A
R
K
S
E
E
L
-
Y
P
G
R
P
-
L
A
I
A
L
D
T
K
G
P
E
I
R
T
G
T
T
T
N
D
V
D
-
Y
P
I
P
P
N
H
E
M
I
F
T
T
-
D
---
D
-
K
YAK
A
--
C
D
D
K
I
M
Y
V
D
Y
K
N
I
T
K
V
I
S
A
G
R
I
I
Y
V
D
D
G
V
L
S
F
Q
V
L
E
V
V
D------
T
L
K
-
V
K
A
L
N
A
G
K
I
C
S
H
K
G
V
N
L
P
G
T
D
V
D
L
P
A
L
S
E
K
D
K
E
D
L
-
R
-
F
G
V
K
N
G
V
H
M
V
F
A
S
F
I
R
T
A
N
D
V
-
L
T
I
R
E
V
L
-
G
E
-------
Q
G
-------
K
D
V
K
I
I
V
K
I
E
N
Q
Q
G
V
N
N
F
D
E
I
L
K
V
T
D
G
V
M
V
A
R
G
D
L
G
I
E
I
P
A
P
E
V
L
A
V
Q
K
K
L
I
A
K
S
N
L
A
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
Y
N
P
R
P
T
R
A
E
V
S
D
V
G
N
A
I
L
D
G
A
D
C
V
M
L
S
G
E
T
A
K
G
N
Y
P
I
N
A
V
T
T
M
A
E
T
A
V
I
A
E
Q
A
I
--------
A
-------
Y
L
P
N
Y
D
D
M
R
N
C
T
P
K
-------
P
T
S
---
T
T
-------
E
T
V
A
A
S
A
V
A
A
V
F
E
Q
K
A
K
A
I
I
V
L
S
T
S
G
T
T
P
R
L
V
S
K
Y
R
P
N
C
P
I
I
L
V
T
R
C
P
R
A
A
R
F
S
H
L
Y
R
G
V
F
P
--
F
V
F
----
E
K
E
PVSD
W
T
D
D
V
E
A
R
I
N
F
G
I
E
K
A
K
E
F
G
I
L
K
----
K
G
D
T
Y
V
S
I
Q
G
F
--
K
A
G
-
A
G
H
S
N
T
L
Q
V
S
T
V
-----
10
PsiBlast_PDB
86.77
37%
-87
- C8 -
3HQN
5
KPYK_LEIME
D:
[20-485]
--
R
A
A
R
I
I
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
G
L
I
Q
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
V
R
Q
A
A
A
E
-
L
-
G
V
N
-
I
A
I
A
L
D
T
K
G
P
E
I
R
T
G
Q
F
V
G
G
-
D
-
A
V
M
E
R
G
A
T
C
Y
V
T
T
-
D
PAF
A
-
D
---
K
--
G
T
K
D
K
F
Y
I
D
Y
Q
N
L
S
K
V
V
R
P
G
N
Y
I
Y
I
D
D
G
I
L
I
L
Q
V
Q
S
H
E
--
D
--
E
-
Q
T
L
E
C
T
V
T
N
S
H
T
I
S
D
R
R
G
V
N
L
P
G
C
D
V
D
L
P
A
V
S
A
K
D
R
V
D
L
-
Q
-
F
G
V
E
Q
G
V
D
M
I
F
A
S
F
I
R
S
A
E
Q
V
-
G
D
V
R
K
A
L
-
G
P
-------
K
G
-------
R
D
I
M
I
I
C
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
E
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
V
V
A
Q
K
I
L
I
S
K
C
N
V
A
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
Y
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
F
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
I
--
C
L
E
A
Q
S
ALNEYVFF
N
-------
S
I
K
K
L
------
Q
H
I
-------
P
M
S
---
A
D
-------
E
A
V
C
S
S
A
V
N
S
V
Y
E
T
K
A
K
A
M
V
V
L
S
N
T
G
R
S
A
R
L
V
A
K
Y
R
P
N
C
P
I
V
C
V
T
T
R
L
Q
T
C
R
Q
L
N
I
T
Q
G
V
E
S
VF
F
D
A
----
D
K
L
------
G
H
D
E
G
K
E
H
R
V
A
A
G
-
V
E
F
A
K
S
K
GYVQ
T
G
D
Y
C
V
V
I
--------------------------
36
PsiBlast_CBE
86.52
37%
-88
- C8 -
3PP7
4
KPYK_LEIME
B:
[19-483]
--
R
A
A
R
I
I
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
G
L
I
Q
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
V
R
Q
A
A
A
E
-
L
-
G
V
N
-
I
A
I
A
L
D
T
K
G
P
E
I
R
T
G
Q
F
V
G
G
-
D
-
A
V
M
E
R
G
A
T
C
Y
V
T
T
-
D
PAF
A
-
D
---
K
--
G
T
K
D
K
F
Y
I
D
Y
Q
N
L
S
K
V
V
R
P
G
N
Y
I
Y
I
D
D
G
I
L
I
L
Q
V
Q
S
H
E
--
D
--
E
-
Q
T
L
E
C
T
V
T
N
S
H
T
I
S
D
R
R
G
V
N
L
P
G
C
D
V
D
L
P
A
V
S
A
K
D
R
V
D
L
-
Q
-
F
G
V
E
Q
G
V
D
M
I
F
A
S
F
I
R
S
A
E
Q
V
-
G
D
V
R
K
A
L
-
G
P
-------
K
G
-------
R
D
I
M
I
I
C
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
E
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
V
V
A
Q
K
I
L
I
S
K
C
N
V
A
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
Y
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
F
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
I
--
C
L
E
A
Q
S
ALNEYVFF
N
-------
S
I
K
K
L
------
Q
H
I
-------
P
M
S
---
A
D
-------
E
A
V
C
S
S
A
V
N
S
V
Y
E
T
K
A
K
A
M
V
V
L
S
N
T
G
R
S
A
R
L
V
A
K
Y
R
P
N
C
P
I
V
C
V
T
T
R
L
Q
T
C
R
Q
L
N
I
T
Q
G
V
E
S
VF
F
D
A
----
D
K
L
------
G
H
D
E
G
K
E
H
R
V
A
A
G
-
V
E
F
A
K
S
K
GYVQ
T
G
D
Y
C
V
V
I
--------------------------
108
PsiBlast_CBE
84.86
39%
-92
- C8 -
4KRZ
2
?
A:
[40-460]
--
R
A
N
R
I
V
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
G
L
I
R
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
L
R
A
A
A
T
E
-
L
-
G
A
H
-
I
G
L
A
L
D
T
K
G
P
E
I
R
T
G
L
F
K
D
G
-
G
-
I
A
L
A
P
G
D
T
V
L
V
T
S
-
D
P--
A
-
F
---
E
KI
G
T
K
E
K
F
Y
I
E
Y
P
R
L
S
I
T
V
R
P
G
G
F
I
Y
I
D
D
G
V
L
S
L
K
V
L
S
K
E
--
D
--
E
-
Y
T
L
K
C
Y
V
N
N
A
H
F
L
T
D
R
K
G
C
N
L
P
G
C
E
V
D
L
P
A
V
S
E
K
D
R
E
D
L
-
K
-
F
G
V
E
Q
G
I
D
M
V
F
A
S
F
I
R
T
A
E
Q
V
-
Q
E
V
R
E
A
L
-
G
E
-------
K
G
-------
K
D
I
L
I
I
S
K
I
E
N
H
Q
G
V
Q
N
I
D
G
I
I
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
V
V
A
Q
M
I
L
I
S
K
C
N
V
A
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
T
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
F
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
I
C
L
E
A
Q
S
A
T
--------
N
-------
Q
A
V
M
F
------
N
S
I
-------
K
K
M
---
Q
K
LPMS
P
E
E
A
V
C
S
S
A
V
N
S
V
Y
E
-
V
R
A
K
A
L
L
V
L
S
N
S
G
R
S
A
R
L
A
S
K
Y
R
P
D
C
P
I
I
C
A
T
T
R
M
R
T
C
R
Q
L
T
I
T
----------------------------------------------------------------------------------
107
PsiBlast_CBE
84.63
39%
-92
- C8 -
4KRZ
2
?
B:
[40-459]
--
R
A
N
R
I
V
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
G
L
I
R
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
L
R
A
A
A
T
E
-
L
-
G
A
H
-
I
G
L
A
L
D
T
K
G
P
E
I
R
T
G
L
F
K
D
G
-
G
-
I
A
L
A
P
G
D
T
V
L
V
T
S
-
D
P--
A
-
F
---
E
KI
G
T
K
E
K
F
Y
I
E
Y
P
R
L
S
I
T
V
R
P
G
G
F
I
Y
I
D
D
G
V
L
S
L
K
V
L
S
K
E
--
D
--
E
-
Y
T
L
K
C
Y
V
N
N
A
H
F
L
T
D
R
K
G
C
N
L
P
G
C
E
V
D
L
P
A
V
S
E
K
D
R
E
D
L
-
K
-
F
G
V
E
Q
G
I
D
M
V
F
A
S
F
I
R
T
A
E
Q
V
-
Q
E
V
R
E
A
L
-
G
E
-------
K
G
-------
K
D
I
L
I
I
S
K
I
E
N
H
Q
G
V
Q
N
I
D
G
I
I
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
V
V
A
Q
M
I
L
I
S
K
C
N
V
A
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
T
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
F
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
I
C
L
E
A
Q
S
A
T
--------
N
-------
Q
A
V
M
F
------
N
S
I
-------
K
K
M
---
Q
K
LPMSPEE
A
V
C
S
S
A
V
N
S
V
Y
E
-
V
R
A
K
A
L
L
V
L
S
N
S
G
R
S
A
R
L
A
S
K
Y
R
P
D
C
P
I
I
C
A
T
T
R
M
R
T
C
R
Q
L
T
I
T
----------------------------------------------------------------------------------
126
PsiBlast_CBE
83.08
38%
-87
- C8 -
4KCT
6
KPYK1_TRYBB
A:
[20-435]
--
R
A
N
R
I
V
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
N
L
M
K
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
V
R
A
A
A
A
E
-
L
-
G
L
H
-
I
G
I
A
L
D
T
K
G
P
E
I
R
T
G
L
F
K
D
G
-
E
-
V
S
F
A
P
G
D
I
V
C
V
T
T
-
D
P--
A
-
Y
---
E
KV
G
T
K
E
K
F
Y
I
D
Y
P
Q
L
T
N
A
V
R
P
G
G
S
I
Y
V
D
D
G
V
M
T
L
R
V
V
S
K
E
--
D
--
D
-
R
T
L
K
C
H
V
N
N
H
H
R
L
T
D
R
R
G
I
N
L
P
G
C
E
V
D
L
P
A
V
S
E
K
D
R
K
D
L
-
E
-
F
G
V
A
Q
G
V
D
M
I
F
A
S
F
I
R
T
A
E
Q
V
-
R
E
V
R
A
A
L
-
G
E
-------
K
G
-------
K
D
I
L
I
I
S
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
A
S
N
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
C
V
A
Q
M
C
I
I
S
K
C
N
V
V
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
S
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
L
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
-
I
C
V
E
A
Q
S
A
--------
T
HDT
V
M
F
N
S
I
K
N
L
------
Q
K
I
-------
P
M
C
---
P
E
-------
E
A
V
C
S
S
A
V
A
S
A
F
E
V
Q
A
K
A
M
L
V
L
S
N
T
G
R
S
A
R
L
I
S
K
Y
R
P
N
C
P
I
I
C
V
T
T
R
L
Q
T
C
R
Q
L
N
V
T
----------------------------------------------------------------------------------
121
PsiBlast_CBE
82.95
38%
-85
- C8 -
4KCV
6
KPYK1_TRYBB
B:
[20-435]
--
R
A
N
R
I
V
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
N
L
M
K
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
V
R
A
A
A
A
E
-
L
-
G
L
H
-
I
G
I
A
L
D
T
K
G
P
E
I
R
T
G
L
F
K
D
G
-
E
-
V
S
F
A
P
G
D
I
V
C
V
T
T
-
D
P--
A
-
Y
---
E
KV
G
T
K
E
K
F
Y
I
D
Y
P
Q
L
T
N
A
V
R
P
G
G
S
I
Y
V
D
D
G
V
M
T
L
R
V
V
S
K
E
--
D
--
D
-
R
T
L
K
C
H
V
N
N
H
H
R
L
T
D
R
R
G
I
N
L
P
G
C
E
V
D
L
P
A
V
S
E
K
D
R
K
D
L
-
E
-
F
G
V
A
Q
G
V
D
M
I
F
A
S
F
I
R
T
A
E
Q
V
-
R
E
V
R
A
A
L
-
G
E
-------
K
G
-------
K
D
I
L
I
I
S
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
A
S
N
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
C
V
A
Q
M
C
I
I
S
K
C
N
V
V
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
S
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
L
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
-
I
C
V
E
A
Q
S
A
--------
T
HDTVMFN
S
I
K
N
L
------
Q
K
I
-------
P
M
C
---
P
E
-------
E
A
V
C
S
S
A
V
A
S
A
F
E
V
Q
A
K
A
M
L
V
L
S
N
T
G
R
S
A
R
L
I
S
K
Y
R
P
N
C
P
I
I
C
V
T
T
R
L
Q
T
C
R
Q
L
N
V
T
----------------------------------------------------------------------------------
124
PsiBlast_CBE
82.91
38%
-87
- C8 -
4KCU
4
KPYK1_TRYBB
A:
[20-435]
--
R
A
N
R
I
V
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
N
L
M
K
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
V
R
A
A
A
A
E
-
L
-
G
L
H
-
I
G
I
A
L
D
T
K
G
P
E
I
R
T
G
L
F
K
D
G
-
E
-
V
S
F
A
P
G
D
I
V
C
V
T
T
-
D
P--
A
-
Y
---
E
KV
G
T
K
E
K
F
Y
I
D
Y
P
Q
L
T
N
A
V
R
P
G
G
S
I
Y
V
D
D
G
V
M
T
L
R
V
V
S
K
E
--
D
--
D
-
R
T
L
K
C
H
V
N
N
H
H
R
L
T
D
R
R
G
I
N
L
P
G
C
E
V
D
L
P
A
V
S
E
K
D
R
K
D
L
-
E
-
F
G
V
A
Q
G
V
D
M
I
F
A
S
F
I
R
T
A
E
Q
V
-
R
E
V
R
A
A
L
-
G
E
-------
K
G
-------
K
D
I
L
I
I
S
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
A
S
N
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
C
V
A
Q
M
C
I
I
S
K
C
N
V
V
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
S
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
L
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
-
I
C
V
E
A
Q
S
A
--------
T
HDT
V
M
F
N
S
I
K
N
L
------
Q
K
I
-------
P
M
C
---
P
E
-------
E
A
V
C
S
S
A
V
A
S
A
F
E
V
Q
A
K
A
M
L
V
L
S
N
T
G
R
S
A
R
L
I
S
K
Y
R
P
N
C
P
I
I
C
V
T
T
R
L
Q
T
C
R
Q
L
N
V
T
----------------------------------------------------------------------------------
119
PsiBlast_CBE
82.69
38%
-85
- C8 -
4KCW
7
KPYK1_TRYBB
B:
[20-435]
--
R
A
N
R
I
V
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
N
L
M
K
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
V
R
A
A
A
A
E
-
L
-
G
L
H
-
I
G
I
A
L
D
T
K
G
P
E
I
R
T
G
L
F
K
D
G
-
E
-
V
S
F
A
P
G
D
I
V
C
V
T
T
-
D
P--
A
-
Y
---
E
KV
G
T
K
E
K
F
Y
I
D
Y
P
Q
L
T
N
A
V
R
P
G
G
S
I
Y
V
D
D
G
V
M
T
L
R
V
V
S
K
E
--
D
--
D
-
R
T
L
K
C
H
V
N
N
H
H
R
L
T
D
R
R
G
I
N
L
P
G
C
E
V
D
L
P
A
V
S
E
K
D
R
K
D
L
-
E
-
F
G
V
A
Q
G
V
D
M
I
F
A
S
F
I
R
T
A
E
Q
V
-
R
E
V
R
A
A
L
-
G
E
-------
K
G
-------
K
D
I
L
I
I
S
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
A
S
N
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
C
V
A
Q
M
C
I
I
S
K
C
N
V
V
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
S
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
L
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
-
I
C
V
E
A
Q
S
A
--------
T
HDTVMFN
S
I
K
N
L
------
Q
K
I
-------
P
M
C
---
P
E
-------
E
A
V
C
S
S
A
V
A
S
A
F
E
V
Q
A
K
A
M
L
V
L
S
N
T
G
R
S
A
R
L
I
S
K
Y
R
P
N
C
P
I
I
C
V
T
T
R
L
Q
T
C
R
Q
L
N
V
T
----------------------------------------------------------------------------------
130
PsiBlast_CBE
82.53
38%
-85
- C8 -
4HYV
5
KPYK1_TRYBB
A:
[20-435]
--
R
A
N
R
I
V
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
N
L
M
K
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
V
R
A
A
A
A
E
-
L
-
G
L
H
-
I
G
I
A
L
D
T
K
G
P
E
I
R
T
G
L
F
K
D
G
-
E
-
V
S
F
A
P
G
D
I
V
C
V
T
T
-
D
P--
A
-
Y
---
E
KV
G
T
K
E
K
F
Y
I
D
Y
P
Q
L
T
N
A
V
R
P
G
G
S
I
Y
V
D
D
G
V
M
T
L
R
V
V
S
K
E
--
D
--
D
-
R
T
L
K
C
H
V
N
N
H
H
R
L
T
D
R
R
G
I
N
L
P
G
C
E
V
D
L
P
A
V
S
E
K
D
R
K
D
L
-
E
-
F
G
V
A
Q
G
V
D
M
I
F
A
S
F
I
R
T
A
E
Q
V
-
R
E
V
R
A
A
L
-
G
E
-------
K
G
-------
K
D
I
L
I
I
S
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
A
S
N
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
C
V
A
Q
M
C
I
I
S
K
C
N
V
V
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
S
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
L
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
-
I
C
V
E
A
Q
S
A
--------
T
HDT
V
M
F
N
S
I
K
N
L
------
Q
K
I
-------
P
M
C
---
P
E
-------
E
A
V
C
S
S
A
V
A
S
A
F
E
V
Q
A
K
A
M
L
V
L
S
N
T
G
R
S
A
R
L
I
S
K
Y
R
P
N
C
P
I
I
C
V
T
T
R
L
Q
T
C
R
Q
L
N
V
T
----------------------------------------------------------------------------------
125
PsiBlast_CBE
82.48
38%
-85
- C8 -
4KCT
5
KPYK1_TRYBB
B:
[20-435]
--
R
A
N
R
I
V
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
N
L
M
K
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
V
R
A
A
A
A
E
-
L
-
G
L
H
-
I
G
I
A
L
D
T
K
G
P
E
I
R
T
G
L
F
K
D
G
-
E
-
V
S
F
A
P
G
D
I
V
C
V
T
T
-
D
P--
A
-
Y
---
E
KV
G
T
K
E
K
F
Y
I
D
Y
P
Q
L
T
N
A
V
R
P
G
G
S
I
Y
V
D
D
G
V
M
T
L
R
V
V
S
K
E
--
D
--
D
-
R
T
L
K
C
H
V
N
N
H
H
R
L
T
D
R
R
G
I
N
L
P
G
C
E
V
D
L
P
A
V
S
E
K
D
R
K
D
L
-
E
-
F
G
V
A
Q
G
V
D
M
I
F
A
S
F
I
R
T
A
E
Q
V
-
R
E
V
R
A
A
L
-
G
E
-------
K
G
-------
K
D
I
L
I
I
S
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
A
S
N
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
C
V
A
Q
M
C
I
I
S
K
C
N
V
V
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
S
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
L
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
-
I
C
V
E
A
Q
S
A
--------
T
HDTVMFN
S
I
K
N
L
------
Q
K
I
-------
P
M
C
---
P
E
-------
E
A
V
C
S
S
A
V
A
S
A
F
E
V
Q
A
K
A
M
L
V
L
S
N
T
G
R
S
A
R
L
I
S
K
Y
R
P
N
C
P
I
I
C
V
T
T
R
L
Q
T
C
R
Q
L
N
V
T
----------------------------------------------------------------------------------
122
PsiBlast_CBE
82.17
38%
-84
- C8 -
4KCV
5
KPYK1_TRYBB
A:
[20-435]
--
R
A
N
R
I
V
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
N
L
M
K
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
V
R
A
A
A
A
E
-
L
-
G
L
H
-
I
G
I
A
L
D
T
K
G
P
E
I
R
T
G
L
F
K
D
G
-
E
-
V
S
F
A
P
G
D
I
V
C
V
T
T
-
D
P--
A
-
Y
---
E
KV
G
T
K
E
K
F
Y
I
D
Y
P
Q
L
T
N
A
V
R
P
G
G
S
I
Y
V
D
D
G
V
M
T
L
R
V
V
S
K
E
--
D
--
D
-
R
T
L
K
C
H
V
N
N
H
H
R
L
T
D
R
R
G
I
N
L
P
G
C
E
V
D
L
P
A
V
S
E
K
D
R
K
D
L
-
E
-
F
G
V
A
Q
G
V
D
M
I
F
A
S
F
I
R
T
A
E
Q
V
-
R
E
V
R
A
A
L
-
G
E
-------
K
G
-------
K
D
I
L
I
I
S
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
A
S
N
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
C
V
A
Q
M
C
I
I
S
K
C
N
V
V
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
S
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
L
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
-
I
C
V
E
A
Q
S
A
--------
T
HDT
V
M
F
N
S
I
K
N
L
------
Q
K
I
-------
P
M
C
---
P
E
-------
E
A
V
C
S
S
A
V
A
S
A
F
E
V
Q
A
K
A
M
L
V
L
S
N
T
G
R
S
A
R
L
I
S
K
Y
R
P
N
C
P
I
I
C
V
T
T
R
L
Q
T
C
R
Q
L
N
V
T
----------------------------------------------------------------------------------
129
PsiBlast_CBE
82.08
38%
-84
- C8 -
4HYV
5
KPYK1_TRYBB
B:
[20-435]
--
R
A
N
R
I
V
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
N
L
M
K
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
V
R
A
A
A
A
E
-
L
-
G
L
H
-
I
G
I
A
L
D
T
K
G
P
E
I
R
T
G
L
F
K
D
G
-
E
-
V
S
F
A
P
G
D
I
V
C
V
T
T
-
D
P--
A
-
Y
---
E
KV
G
T
K
E
K
F
Y
I
D
Y
P
Q
L
T
N
A
V
R
P
G
G
S
I
Y
V
D
D
G
V
M
T
L
R
V
V
S
K
E
--
D
--
D
-
R
T
L
K
C
H
V
N
N
H
H
R
L
T
D
R
R
G
I
N
L
P
G
C
E
V
D
L
P
A
V
S
E
K
D
R
K
D
L
-
E
-
F
G
V
A
Q
G
V
D
M
I
F
A
S
F
I
R
T
A
E
Q
V
-
R
E
V
R
A
A
L
-
G
E
-------
K
G
-------
K
D
I
L
I
I
S
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
A
S
N
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
C
V
A
Q
M
C
I
I
S
K
C
N
V
V
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
S
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
L
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
-
I
C
V
E
A
Q
S
A
--------
T
HDTVMFN
S
I
K
N
L
------
Q
K
I
-------
P
M
C
---
P
E
-------
E
A
V
C
S
S
A
V
A
S
A
F
E
V
Q
A
K
A
M
L
V
L
S
N
T
G
R
S
A
R
L
I
S
K
Y
R
P
N
C
P
I
I
C
V
T
T
R
L
Q
T
C
R
Q
L
N
V
T
----------------------------------------------------------------------------------
123
PsiBlast_CBE
81.86
38%
-87
- C8 -
4KCU
4
KPYK1_TRYBB
B:
[20-435]
--
R
A
N
R
I
V
C
T
I
G
P
S
T
Q
S
V
E
A
L
K
N
L
M
K
S
G
M
S
V
A
R
M
N
F
S
H
G
S
H
E
Y
H
Q
T
T
I
N
N
V
R
A
A
A
A
E
-
L
-
G
L
H
-
I
G
I
A
L
D
T
K
G
P
E
I
R
T
G
L
F
K
D
G
-
E
-
V
S
F
A
P
G
D
I
V
C
V
T
T
-
D
P--
A
-
Y
---
E
KV
G
T
K
E
K
F
Y
I
D
Y
P
Q
L
T
N
A
V
R
P
G
G
S
I
Y
V
D
D
G
V
M
T
L
R
V
V
S
K
E
--
D
--
D
-
R
T
L
K
C
H
V
N
N
H
H
R
L
T
D
R
R
G
I
N
L
P
G
C
E
V
D
L
P
A
V
S
E
K
D
R
K
D
L
-
E
-
F
G
V
A
Q
G
V
D
M
I
F
A
S
F
I
R
T
A
E
Q
V
-
R
E
V
R
A
A
L
-
G
E
-------
K
G
-------
K
D
I
L
I
I
S
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
A
S
N
G
I
M
V
A
R
G
D
L
G
V
E
I
P
A
E
K
V
C
V
A
Q
M
C
I
I
S
K
C
N
V
V
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
S
N
P
R
P
T
R
A
E
V
S
D
V
A
N
A
V
L
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
-
I
C
V
E
A
Q
S
A
--------
T
HDTVMFN
S
I
K
N
L
------
Q
K
I
-------
P
M
C
---
P
E
-------
E
A
V
C
S
S
A
V
A
S
A
F
E
V
Q
A
K
A
M
L
V
L
S
N
T
G
R
S
A
R
L
I
S
K
Y
R
P
N
C
P
I
I
C
V
T
T
R
L
Q
T
C
R
Q
L
N
V
T
----------------------------------------------------------------------------------