@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1620c: (2016-05-03 )
MNRPSAVSRRQRDLLAASGLLGPRLPRILAAVALGVLSLGSALALAGVSAWLITRAWQMPPVLDLSVAVVAVRAFAISRGVLHYCERLATHDTALRAAGRARTLIYHRLAHGPAAAAVGLHSGDLAARVGADVDELANMLVRALVPIAVAAVLAVAATAVVAAVSVPAAVVLAVCLLVAGVVAPWLAGRTAAAQEAIARQHRGMRDTSAMIALEHAPELRVAGALRNVIADSQRRQHAWADALDAAARTGAIAEAMPTAAIGASLLGAVVAGIGMAPTVAPTTLAILMLLPLSAFEATVALPAAAVQLTRSRIAAARLLDLTGSNRVRETESTVSARLPVGTGVLAADVCCGHQEAQSIRVTIDLPPGARLAVTGASGAGKTTLLMTLAGLLPPVHGRVLLDGTNLSDFDEDELRSAVSFFAEDAHIFATTVRDNLLTARGDCPDDELIEALDRVGLCGWLAGLPEGLSTVLIGGAQAVSAGQRRRLLLARAVLSPARIVLLDEPVEHLDAANADLLRDLLAPNSGIMSAMRTVVVATHHLPNDIQCAELSIATDQRCRRRGTNSSDNNTNASAKT
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20......-..30........40......--..50.-.......------60--.------.---..---------.-.---.-..-70........80........90........100.......110-----.......120.......130.......140........150......-.160.....----..170---........180........190.......200.......210..--......220...--....230.......240.......-250....-----.-..260.......270..----.-------....280.......290.......300----....-----...310..---....---.320.......330.----.-...-..340......---.350...----....--360--.........370.......380.......390...---....400.......410.......420.......430.....--..440.---.......450.......460.......470.......480.......490.......500.......510...-....520.......530.......540.......550.......560.......570....-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNR
P
S
A
V
S
R
R
Q
R
D
L
L
A
ASGLLGP
R
L
P
R
-
I
L
A
A
V
A
L
G
V
L
S
L
G
S
A
L
A
L
A
G
--
V
S
A
W
L
-
I
T
RAWQM------P---P------
V
---
L
D
---------
L
-
S
---
V
-
A
V
-
V
A
V
R
A
F
A
I
S
R
G
V
L
H
Y
C
E
R
L
AT
H
D
T
A
L
R
AAGR
A
R
T
L
I
Y
H
RLAHG-----PA
A
A
A
V
GLHSG
D
L
A
A
RVGA
D
V
D
E
L
A
N
M
L
-
V
R
A
L
V
P
I
A
V
A
A
V
L
A
V
A
A
T
-
A
V
V
A
A
VS
V
P
----
A
A
V
V
----
L
A
V
C
L
L
V
A
G
-
V
V
A
P
W
LAG
R
T
A
A
A
Q
E
A
I
A
R
Q
HRGMRD
T
S
A
M
I
-
A
L--EHAPE
L
R
V
A
G
A
L
--
R
N
V
I
A
D
S
Q
R
R
Q
H
A
W
A
D
A
L
D
A
A
ART-
G
A
I
A
E
AM-----
P
-
T
A
A
I
G
A
S
L
L
G
A
V
V
AGIG----M-------APTV
A
P
T
T
L
A
I
L
M
LLP
L
S
A
F
E
A
T
VAL
P
----
A
A
A
V
-----
Q
L
T
R
S
R
I
A
---
A
A
R
L
---
L
DLTGSNRVRETEST----V-SAR-LPVG
T
G
V
L
A
A
D
---VCCGHQE----A
Q
S
I
--
R
----
V
T
I
DLPPG
A
R
L
A
V
TGASGAG
K
T
T
L
L
M
T
L
A
G
LLPPV---H
G
R
V
L
L
DGTNLSDF
D
E
D
E
L
R
S
A
V
S
F
F
AED
A
H
I
F
A
T
TVRDNLL--TARG-D---CP
D
D
E
L
I
E
A
L
D
RVG
L
C
G
W
L
A
GLP
E
G
L
S
T
V
L
IGG
A
Q
AVSAG
Q
R
R
R
L
L
L
A
R
A
VLSP
A
R
I
V
L
LDE
P
V
E
H
LDAA
N
A
D
-
L
L
R
D
L
LAP
N
S
G
I
M
S
A
M
R
T
V
V
V
A
THHLPNDI
Q
C
A
E
L
S
IA
T
D
Q
R
C
R
RRGTNSSDNNTNASAKT-------
5
PsiBlast_PDB
83.78
21%
-106
- C1 -
2HYD
3
Y1866_STAAM
A:
[8-559]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
--
L
I
K
Y
A
-
I
D
G
V
I
N
N
HALT
T
D
E
---
K
------
V
---
H
H
---------
L
-
T
---
I
-
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
-----
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
-
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
-
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
----
F
P
F
Y
I
L
T
V
Y
-
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
-
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
-
I
-
N
T
V
T
D
I
G
-----
P
-
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
----
V
-------
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
------
L
V
----
A
S
F
T
-----
T
L
T
Q
S
F
A
S
---
M
D
R
V
---
F
Q
L
I
D
E
D
Y
--
D
I
K
N
G
----
V
-
G
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
E
----
A
P
I
L
--
K
D
---
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
--
L
G
R
P
-
T
---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
-
I
I
Q
E
A
L
----
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
-------------------
6
PsiBlast_PDB
82.46
21%
-103
- C1 -
2ONJ
4
Y1866_STAAM
A:
[8-559]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
--
L
I
K
Y
A
-
I
D
G
V
I
N
N
HALT
T
D
E
---
K
------
V
---
H
H
---------
L
-
T
---
I
-
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
-----
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
-
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
-
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
----
F
P
F
Y
I
L
T
V
Y
-
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
-
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
-
I
-
N
T
V
T
D
I
G
-----
P
-
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
----
V
-------
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
------
L
V
----
A
S
F
T
-----
T
L
T
Q
S
F
A
S
---
M
D
R
V
---
F
Q
L
I
D
E
D
Y
--
D
I
K
N
G
----
V
-
G
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
E
----
A
P
I
L
--
K
D
---
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
--
L
G
R
P
-
T
---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
-
I
I
Q
E
A
L
----
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
-------------------
1
PsiBlast_PDB
80.51
20%
-121
- C1 -
4RY2
-
?
A:
[152-706]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
M
M
V
K
F
A
G
F
L
K
P
-
L
K
K
-
T
V
L
C
I
F
L
A
S
L
-
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
-
F
D
D
L
I
K
F
------
E
---
K
------
L
---
N
D
---------
L
-
H
---
I
-
I
S
-
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
-----
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
-
M
D
A
S
K
I
R
Q
A
I
-
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
-
I
L
L
Y
I
Q
N
S
S
----
L
F
F
I
----
S
F
I
I
I
L
L
Y
G
-
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
--
T
S
A
L
V
E
S
V
--
K
G
I
E
T
I
K
S
F
G
A
---------
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
--
S
F
K
E
G
M
--------
L
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
----
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
----
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
---
S
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
------------------
G
D
I
E
F
R
N
V
D
---
F
R
Y
G
L
R
K
----
P
V
L
K
--
N
----
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
--
L
G
N
E
-
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
-
H
I
K
D
A
I
Y
---
G
L
E
D
D
V
-
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
-----------------
4
PsiBlast_PDB
76.86
20%
-111
- C2 -
4S0F
2
?
A:
[161-709]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
G
F
L
K
P
-
L
K
K
-
T
V
L
C
I
F
L
A
S
L
-
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
-
F
D
D
L
I
K
F
------
E
---
K
------
L
---
N
D
---------
L
-
H
---
I
-
I
S
-
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
-----
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
-
M
D
A
S
K
I
R
Q
A
I
-
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
-
I
L
L
Y
I
Q
N
S
S
----
L
F
F
I
----
S
F
I
I
I
L
L
Y
G
-
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
--
T
S
A
L
V
E
S
V
--
K
G
I
E
T
I
K
S
F
G
A
---------
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
--
S
F
K
E
G
M
--------
L
Y
I
N
L
S
S
L
T
G
I
V
A
G
L
G
----
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
----
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
---
S
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
R
E
D
S
D
D
----
F
-
V
I
S
-
L
K
G
D
I
E
F
R
N
V
D
---
F
R
Y
G
L
R
K
----
P
V
L
K
--
N
----
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
--
L
G
N
E
-
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
-
H
I
K
D
A
I
Y
---
G
L
E
D
D
V
-
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
-----------------
7
PsiBlast_PDB
73.32
21%
-106
- C1 -
4A82
-
Y1866_STAAM
A:
[8-559]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
--
L
I
K
Y
A
-
I
D
G
V
I
N
N
HALT
T
D
E
---
K
------
V
---
H
H
---------
L
-
T
---
I
-
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
-----
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
-
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
-
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
----
F
P
F
Y
I
L
T
V
Y
-
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
-
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
-
I
-
N
T
V
T
D
I
G
-----
P
-
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
----
V
-------
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
------
L
V
----
A
S
F
T
-----
T
L
T
Q
S
F
A
S
---
M
D
R
V
---
F
Q
L
I
D
E
D
Y
--
D
I
K
N
G
----
V
-
G
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
E
----
A
P
I
L
--
K
D
---
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
--
L
G
R
P
-
T
---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
-
I
I
Q
E
A
L
----
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
-------------------
9
PsiBlast_PDB
72.63
21%
-120
- C2 -
4Q4A
1
Y288_THEMA
B:
[111-561]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
R
K
E
L
F
E
K
L
Q
R
V
-----
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
-
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
-
I
M
M
F
R
V
N
V
I
----
L
S
L
V
T
L
SI
V
P
L
T
V
L
I
T
Q
-
I
V
S
-------
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
---------
E
E
D
I
S
G
L
T
--
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
-
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
-------
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
---
S
R
Q
F
T
R
P
L
N
----
E
L
S
N
-----
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
---
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
----
V
-
E
L
R
--
E
V
R
G
E
I
E
F
K
N
---
V
W
F
S
Y
D
K
----
K
K
P
V
LK
D
----
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
--
Y
G
N
P
-
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
----
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
--
H
R
L
N
T
I
K
N
A
D
L
I
I
V
------------------------------
103
HHSearch
71.70
18%
-102
- C1 -
4MRS
12
ATM1_NOVAD
A:
[38-587]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
V
V
G
A
I
L
M
V
L
L
G
K
A
T
T
L
A
L
P
F
--
A
Y
K
K
A
-
V
D
A
M
T
L
G
------
G
---
G
AQP---
A
---
L
T
---------
V
-
A
---
L
A
F
V
-
L
A
Y
A
L
G
R
F
S
G
V
L
F
D
N
L
R
N
I
V
F
E
R
V
G
Q
D
A
T
R
H
L
A
E
N
V
F
A
R
L
H
K
L
-----
S
L
R
F
H
L
A
R
R
T
G
E
V
T
K
V
I
E
R
G
T
K
S
I
D
T
M
L
-
Y
F
L
L
F
N
I
A
P
T
V
-
I
E
L
T
A
V
-
I
V
I
F
W
L
N
F
G
----
L
G
L
V
----
T
A
T
I
L
A
V
I
A
Y
V
W
T
T
R
T
I
T
E
W
R
T
H
L
R
E
K
M
N
R
L
D
G
Q
A
L
A
R
A
V
D
-
S
L
--
L
N
Y
E
T
V
K
Y
F
G
A
E
--
S
R
E
E
A
R
Y
A
S
A
A
R
A
Y
A
D
A
A
V
K
S
E
N
S
-
L
G
L
L
N
I
A
-----
Q
-
A
L
I
V
N
L
L
M
A
G
A
M
A
W
T
V
Y
----
G
W
S
-----
Q
G
K
L
T
V
G
D
L
V
F
V
N
T
Y
L
T
Q
L
F
R
P
L
D
M
L
G
----
M
V
Y
R
-----
T
I
R
Q
G
L
I
D
---
M
A
E
M
---
F
R
L
I
D
T
H
I
E
V
A
D
V
P
N
----
A
-
P
A
L
-
V
V
N
R
P
S
V
T
F
D
N
---
V
V
F
G
Y
D
R
DR--
E
I
L
H
--
G
----
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
---
E
G
R
I
L
I
D
G
Q
D
I
A
H
V
T
Q
T
S
L
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
N
D
T
I
G
Y
N
I
A
--
Y
G
R
D
-
G
---
A
S
R
A
E
V
D
A
A
A
K
G
A
A
I
A
D
F
I
A
R
L
P
Q
G
Y
D
T
E
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
I
L
L
F
D
E
A
T
S
A
L
D
T
R
T
E
Q
D
I
L
S
T
M
-
R
A
----
V
A
S
H
R
T
T
I
S
I
A
H
R
L
S
T
I
A
D
S
D
T
I
L
V
L
D
Q
G
R
L
A
E
Q
G
S
H
L
D
L
L
R
R
D
G
-----------
108
HHSearch
71.11
18%
-98
- C1 -
3WMG
6
?
A:
[10-582]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
V
T
A
R
R
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
--
V
F
G
R
M
-
F
Q
V
F
T
K
S
------
K
---
S
Q
-----
I
E
--
G
E
---------
T
-
W
---
K
-
Y
S
-
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
-----
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
-
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
-
I
V
A
F
I
F
A
P
A
----
L
T
G
V
----
L
I
A
L
S
P
L
V
V
-
L
A
V
-
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
-
V
F
--
S
N
I
R
T
T
K
A
F
E
A
E
--
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
-
D
G
L
F
F
G
L
-----
S
-
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
----
L
I
A
-----
R
G
S
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
----
Q
V
W
P
-----
D
V
T
R
G
L
G
A
---
G
G
E
L
---
F
A
M
I
D
R
V
P
Q
Y
R
R
P
D
P
G
A
E
V
V
-
T
Q
P
-
L
V
L
K
Q
G
I
V
F
E
N
---
V
H
F
R
Y
P
T
RMNV
E
V
L
R
--
G
----
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
--
Y
G
K
R
-
D
---
A
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
---
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
-------------
10
PsiBlast_PDB
70.04
21%
-118
- C2 -
4Q4H
-
Y288_THEMA
B:
[111-561]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
R
K
E
L
F
E
K
L
Q
R
V
-----
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
-
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
-
I
M
M
F
R
V
N
V
I
----
L
S
L
V
T
L
SI
V
P
L
T
V
L
I
T
Q
-
I
V
S
-------
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
---------
E
E
D
I
S
G
L
T
--
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
-
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
-------
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
---
S
R
Q
F
T
R
P
L
N
----
E
L
S
N
-----
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
---
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
----
V
-
E
L
R
--
E
V
R
G
E
I
E
F
K
N
---
V
W
F
S
Y
D
K
----
K
K
P
V
LK
D
----
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
--
Y
G
N
P
-
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
----
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
--
H
R
L
N
T
I
K
N
A
D
L
I
I
V
------------------------------
8
PsiBlast_PDB
69.87
21%
-118
- C2 -
3QF4
1
Y288_THEMA
B:
[111-561]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
R
K
E
L
F
E
K
L
Q
R
V
-----
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
-
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
-
I
M
M
F
R
V
N
V
I
----
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
-
I
V
S
-------
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
---------
E
E
D
I
S
G
L
T
--
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
-
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
-------
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
---
S
R
Q
F
T
R
P
L
N
----
E
L
S
N
-----
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
---
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
----
V
-
E
L
R
--
E
V
R
G
E
I
E
F
K
N
---
V
W
F
S
Y
D
K
----
K
K
P
V
LK
D
----
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
--
Y
G
N
P
-
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
----
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
--
H
R
L
N
T
I
K
N
A
D
L
I
I
V
------------------------------
101
HHSearch
69.60
16%
-101
- C1 -
4Q4H
-
Y288_THEMA
B:
[21-581]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
--
L
I
G
K
T
-
I
D
V
V
F
V
P
------
R
---
R
------
F
---
D
L
---------
L
-
P
---
R
-
Y
M
-
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
-----
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
-
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
-
I
M
M
F
R
V
N
V
I
----
L
S
L
V
----
T
L
S
I
V
P
L
T
V
--
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
-
D
I
--
S
G
L
T
V
I
K
L
F
T
R
E
--
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
-
S
G
V
L
P
P
L
-----
M
-
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
----
L
A
L
-----
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
----
N
Q
F
N
-----
M
I
Q
M
A
L
A
S
---
A
E
R
I
---
F
E
I
L
D
L
E
E
E
K
D
-
D
P
D
----
A
-
V
E
L
-
R
E
V
R
G
E
I
E
F
K
N
---
V
W
F
S
Y
D
K
KK--
P
V
L
K
--
D
----
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
--
Y
G
N
P
-
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
-
S
I
Q
A
A
M
W
K
----
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
-----------
97
HHSearch
69.48
16%
-107
- C1 -
4RY2
-
?
A:
[155-713]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
K
F
A
G
F
L
K
P
L
K
K
T
-
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
--
Y
I
K
F
L
-
F
D
D
L
I
K
F
------
E
---
K
------
L
---
N
D
---------
L
-
H
---
I
-
I
S
-
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
-----
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
-
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
-
I
L
L
Y
I
Q
N
S
S
----
L
F
F
I
----
S
F
I
I
I
L
L
Y
G
-
I
I
-
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
-
S
V
--
K
G
I
E
T
I
K
S
F
G
A
E
--
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
-
Y
I
N
L
S
S
L
-----
T
-
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
----
N
V
I
-----
K
G
N
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
----
D
L
Q
P
-----
L
I
Q
T
A
V
V
A
---
S
N
R
L
---
G
E
I
L
E
L
A
T
E
K
E
L
-----------------
G
D
I
E
F
R
N
---
V
D
F
R
Y
G
L
RK--
P
V
L
K
--
N
----
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
--
L
G
N
E
-
N
---
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
-
Y
G
----
L
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
K
G
C
----------
11
PsiBlast_PDB
68.80
21%
-117
- C2 -
4Q4J
-
Y288_THEMA
B:
[111-561]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
R
K
E
L
F
E
K
L
Q
R
V
-----
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
-
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
-
I
M
M
F
R
V
N
V
I
----
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
-
I
V
S
-------
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
---------
E
E
D
I
S
G
L
T
--
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
-
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
-------
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
---
S
R
Q
F
T
R
P
L
N
----
E
L
S
N
-----
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
---
F
E
I
L
D
L
E
E
E
K
D
D
P
D
A
----
V
-
E
L
R
--
E
V
R
G
E
I
E
F
K
N
---
V
W
F
S
Y
D
K
----
K
K
P
V
LK
D
----
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
--
Y
G
N
P
-
G
---
A
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
----
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
--
H
R
L
N
T
I
K
N
A
D
L
I
I
V
------------------------------
100
HHSearch
68.23
18%
-95
* C1 *
3ZDQ
6
ABCBA_HUMAN
A:
[4-571]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
--
F
L
G
K
I
-
I
D
V
I
Y
T
N
------
P
---
T
------
V
DY
S
D
N
---------
L
-
T
---
R
-
L
C
-
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
-----
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
-
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
-
S
M
M
F
F
V
S
P
N
----
L
A
T
F
----
V
L
S
V
V
P
P
V
S
--
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
-
R
I
--
G
N
V
R
T
V
R
A
F
G
K
E
--
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
-
R
A
G
F
F
G
A
-----
T
-
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
----
L
M
G
-----
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
----
S
F
Y
S
-----
E
L
M
K
G
L
G
A
---
G
G
R
L
---
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
V
---
I
-
L
N
E
-
K
S
F
Q
G
A
L
E
F
K
N
---
V
H
F
A
Y
P
A
RPEV
P
I
F
Q
--
D
----
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
--
Y
G
A
D
-
D
PSS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
-
L
V
Q
E
A
L
D
R
----
L
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
-------------
98
HHSearch
66.67
18%
-92
- C1 -
3B60
2
MSBA_SALTY
A:
[12-570]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
--
L
L
K
P
L
-
L
D
D
G
F
G
K
------
T
---
D
------
R
---
S
V
---------
L
-
L
---
W
-
M
P
-
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
-----
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
-
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
-
I
M
M
F
Y
Y
S
W
Q
----
L
S
I
I
----
L
V
V
L
A
P
I
V
S
-
I
A
-
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
-
M
L
--
K
G
H
K
E
V
L
I
F
G
G
Q
--
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
-
S
S
I
S
D
P
I
-----
I
-
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
----
P
SV-----
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
----
N
V
N
A
-----
Q
F
Q
R
G
M
A
A
---
C
Q
T
L
---
F
A
I
L
D
S
E
Q
E
K
D
--
E
G
----
K
-
R
V
I
-
D
R
A
T
G
D
L
E
F
R
N
---
V
T
F
T
Y
P
G
REV-
P
A
L
R
--
N
----
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
--
Y
A
R
T
E
E
---
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
-
A
I
Q
A
A
L
D
E
----
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
-----------
117
Fugue
65.56
17%
-89
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
--
L
L
K
P
L
-
L
D
D
G
F
G
K
------
T
---
D
------
R
---
S
V
---------
L
-
L
---
W
-
M
P
-
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
-----
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
-
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
-
I
M
M
F
Y
Y
S
W
Q
----
L
S
I
I
----
L
V
V
L
A
P
I
V
S
-
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
-
L
K
--
G
H
K
E
V
L
I
F
G
G
Q
E
--
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
-
S
I
S
D
P
I
I
-----
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
----
V
-------
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
----
N
V
N
A
-----
Q
F
Q
R
G
M
A
A
---
C
Q
T
L
---
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
R
----
V
-
I
D
R
-
A
T
G
D
L
E
F
R
N
V
T
---
F
T
Y
P
G
R
E
----
V
P
A
L
--
R
N---
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
--
Y
A
R
T
-
E
E--
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
-
A
I
Q
A
A
L
D
E
L
Q
K
----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
QFG
105
HHSearch
64.61
17%
-101
- C1 -
4MYC
-
ATM1_YEAST
A:
[115-663]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
L
I
S
A
K
I
L
N
V
Q
V
P
F
--
F
F
K
Q
T
-
I
D
S
M
N
I
A
------
W
DDP
T
------
V
---
A
L
---------
P
-
A
A
I
G
L
-
T
I
-
L
C
Y
G
V
A
R
F
G
S
V
L
F
G
E
L
R
N
A
V
F
A
K
V
A
Q
N
A
I
R
T
V
S
L
Q
T
F
Q
H
L
M
K
L
-----
D
L
G
W
H
L
S
R
Q
T
G
G
L
T
R
A
M
D
R
G
T
K
G
I
S
Q
V
L
-
T
A
M
V
F
H
I
I
P
I
S
F
E
I
S
V
V
C
G
I
L
T
Y
Q
F
G
A
S
----
F
A
A
I
----
T
F
S
T
M
L
L
Y
S
-
I
F
-
T
I
K
T
T
A
W
R
T
H
F
R
R
D
A
N
K
A
D
N
K
A
A
S
V
A
L
D
-
S
L
--
I
N
F
E
A
V
K
Y
F
N
N
E
--
K
Y
L
A
D
K
Y
N
G
S
L
M
N
Y
R
D
S
Q
I
K
V
S
Q
S
-
L
A
F
L
N
S
G
-----
Q
-
N
L
I
F
T
T
A
L
T
A
M
M
Y
M
G
C
T
----
G
V
I
-----
G
G
N
L
T
V
G
D
L
V
L
I
N
Q
L
V
F
Q
L
S
V
P
L
N
F
L
G
----
S
V
Y
R
-----
D
L
K
Q
S
L
I
D
---
M
E
T
L
---
F
K
L
R
K
N
E
V
K
I
K
N
A
E
R
----
P
L
M
L
P
-
E
N
V
P
Y
D
I
T
F
E
N
---
V
T
F
G
Y
H
P
DR--
K
I
L
K
--
N
----
A
S
F
T
I
P
A
G
W
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
D
P
E
---
S
G
R
I
L
I
N
G
R
D
I
K
E
Y
D
I
D
A
L
R
K
V
I
G
V
V
P
Q
D
T
P
L
F
N
D
T
I
W
E
N
V
K
--
F
G
R
I
-
D
---
A
T
D
E
E
V
I
T
V
V
E
K
A
Q
L
A
P
L
I
K
K
L
P
Q
G
F
D
T
I
V
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
R
D
N
F
---
T
S
G
S
R
T
S
V
Y
I
A
H
R
L
R
T
I
A
D
A
D
K
I
I
V
L
D
N
G
R
V
R
E
E
G
K
H
L
E
L
L
A
M
P
------------
122
Fugue
63.89
17%
-95
- C1 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
QE
I
S
W
F
D
T
N
HSGT
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
GD
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
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A
K
S
M
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T
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T
L
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K
V
V
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T
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S
S
I
R
T
V
V
S
L
NG
L
R
Y
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L
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T
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K
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L
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N
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A
L
A
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Y
I
G
V
G
W
V
H
D
GSLN
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
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G
I
Y
E
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LDRKPVIDSS
S
K
A
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R
KDMKIK
G
D
I
T
V
E
N
V
H
F
T
Y
PSRPDVPILRG
M
N
L
R
V
N
AGQT
V
A
L
V
G
S
SGCG
K
S
T
I
I
S
L
L
L
RYYDVL
K
G
K
I
T
I
DGVDVRDIN
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
NCT
I
E
E
N
I
S
L
G
KEGIT
R
E
E
M
V
A
A
C
K
M
A
NA
E
K
F
I
K
T
L
PNGYNTLVGDR
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
RNPK
I
L
L
L
D
EATSALDAES
E
G
I
V
Q
Q
A
L
D
K
A
A
KG
R
T
T
I
I
I
A
HRLSTIRNAD
L
I
I
S
C
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E
V
G
D
H
R
A
L
M
A
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QG
L
Y
Y
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L
V
T
A
Q
T
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A
V
D
S
A
A
E
GE
R
I
G
K
D
A
L
S
R
L
K
Q
E
L
-
E
E
N
N
A
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K
T
N
L
F
E
-
I
L
Y
H
A
R
P
H
A
L
S
L
F
I
G
M
S
T
A
T
--
I
G
G
F
I
Y
P
T
Y
S
V
F
F
------
T
---
S
------
F
---
M
N
V
F
AGNPADF
L
-
S
---
Q
-
G
H
-
F
W
A
L
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F
L
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L
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L
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L
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L
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G
F
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L
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L
R
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T
T
L
V
S
M
V
A
G
I
G
-
L
A
F
F
Y
G
W
Q
M
----
A
L
L
I
----
I
A
I
L
P
I
V
A
---
F
G
Q
Y
L
R
G
R
R
F
T
G
K
N
V
K
S
A
S
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K
I
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-
A
I
--
E
N
V
R
T
V
Q
A
L
A
R
E
--
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
-
Q
G
L
S
Y
G
C
-----
A
-
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
----
L
-------
I
I
T
D
P
P
T
M
Q
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
T
L
GFAT
S
Y
F
P
-----
E
Y
A
K
A
T
F
A
---
G
G
I
I
---
F
G
M
L
R
K
I
S
K
I
D
S
L
S
L
----
A
-
G
E
K
-
K
K
L
Y
G
K
V
I
F
K
N
---
V
R
F
A
Y
P
E
----
R
P
E
I
--
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ILK
G
L
S
F
S
V
E
P
G
Q
T
L
A
L
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C
G
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V
A
L
L
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R
F
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---
G
G
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N
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N
I
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L
D
P
S
-
S
---
V
T
M
A
Q
V
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A
A
R
L
A
N
I
H
N
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A
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R
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P
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I
L
L
L
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A
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S
A
L
D
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S
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K
-
V
V
Q
E
A
L
D
R
----
A
R
E
G
R
T
C
I
V
I
A
H
R
L
N
T
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M
N
A
D
C
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A
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V
S
N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
E
K
------------
102
HHSearch
62.62
18%
-98
- C1 -
4A82
-
Y1866_STAAM
A:
[2-567]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
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F
G
I
P
M
L
I
P
L
--
L
I
K
Y
A
-
I
D
G
V
I
N
N
------
H
---
A
LT
T
D
E
K
V
---
H
H
---------
L
T
I
---
A
-
I
G
-
I
A
L
F
I
F
V
I
V
R
P
P
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K
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D
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K
K
L
Y
N
H
L
Q
A
L
-----
S
A
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Y
A
N
N
Q
V
G
Q
V
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V
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D
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-
L
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L
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W
L
D
C
I
T
I
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A
L
-
S
I
M
F
F
L
D
V
K
----
L
T
L
A
----
A
L
F
I
F
P
F
Y
I
--
L
T
V
Y
V
F
F
G
R
L
R
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L
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A
L
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L
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A
L
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W
-
N
A
Y
S
F
A
A
-----
I
-
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
----
L
A
I
-----
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
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L
R
R
L
V
----
A
S
F
T
-----
T
L
T
Q
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F
A
S
---
M
D
R
V
---
F
Q
L
I
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D
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D
I
K
N
G
V
G
----
A
-
Q
P
I
-
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I
K
Q
G
R
I
D
I
D
H
---
V
S
F
Q
Y
N
D
NEA-
P
I
L
K
--
D
----
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
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N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
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I
L
--
L
G
R
P
-
T
---
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
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L
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L
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G
G
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N
N
P
P
I
L
I
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A
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A
L
D
L
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S
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S
-
I
I
Q
E
A
L
D
V
----
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
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H
A
D
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I
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V
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N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
-----------
99
HHSearch
61.82
18%
-91
- C- -
3B5X
-
MSBA_VIBCH
A:
[11-572]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
F
K
R
L
W
T
Y
I
R
L
Y
K
A
G
-
L
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
--
L
L
K
P
L
-
L
D
E
G
F
G
N
------
A
---
E
------
S
---
N
F
---------
L
-
R
---
I
-
L
P
-
F
M
I
L
G
L
M
F
V
R
G
L
S
G
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A
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C
L
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W
V
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G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
-----
P
V
R
F
F
D
Q
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G
L
L
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A
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I
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L
L
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L
M
F
W
N
S
W
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----
L
S
L
V
----
L
I
V
V
A
P
V
V
A
-
F
A
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I
S
F
V
S
K
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F
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-----
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-
Q
M
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A
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L
A
L
F
A
V
L
F
L
A
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----
D
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R
A
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L
T
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G
T
F
T
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V
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L
M
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L
K
A
L
T
----
S
V
T
S
-----
E
F
Q
R
G
M
A
A
---
C
Q
T
L
---
F
G
L
M
D
L
E
T
E
R
D
--
N
G
----
K
-
Y
E
A
-
E
R
V
N
G
E
V
D
V
K
D
---
V
T
F
T
Y
Q
G
KEK-
P
A
L
S
--
H
----
V
S
F
S
I
P
Q
G
K
T
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A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
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F
Y
D
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---
S
G
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C
L
D
G
H
D
V
R
D
Y
K
L
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N
L
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H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
--
Y
A
A
E
G
E
---
Y
T
R
E
Q
I
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Q
A
A
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Q
A
H
A
M
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F
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M
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L
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A
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V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
-
A
I
Q
A
A
L
D
E
----
L
Q
K
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
D
G
A
Y
---------