@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1625c: (2016-05-03 )
MAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV
Atome Classification :
(50 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260--.......---.----.270.......280.......---290--........300.......310--.......--------..320.......330.......340.......350.......360.......370.......380.......390.------.....------.400..--.....410.----..-....420.......430.......440.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAARKCGAPPIAADGSTRRP
D
C
V
T
A
V
R
TQARA
P
T
Q
H
Y
A
E
S
V
A
RRQ
R
V
L
T
I
T
A
W
L
A
V
V
VTG
S
F
A
L
M
Q
LATGAG
G
W
Y
I
A
L
I
N
V
F
T
A
V
T
F
A
I
V
P
L
L
H
R
FG
G
L
V
A
P
L
T
F
I
G
T
A
Y
V
A
I
F
A
I
GWDVGTDA
G
A
Q
F
F
F
L
V
A
A
A
L
V
V
L
L
VGI
E
H
T
A
L
A
V
G
L
A
A
V
A
A
G
L
V
I
A
L
E
F
LVPPDTGLQPP
W
A
M
S
V
S
F
V
L
T
T
V
S
A
C
G
V
A
V
A
T
V
W
F
A
L
RDT
A
R
A
E
A
V
M
E
AEH
D
R
S
E
A
L
L
A
N
M
L
P
A
S
I
A
E
R
LKEPERNIIADKYDE
A
S
V
L
F
A
D
I
VGF----TERASST---
A
----
P
A
D
L
V
R
F
L
D
R
L
Y
S
A
F
D
E
L
V
D
Q---HG---L
E
K
I
K
VSGD
S
Y
M
V
V
SGVPR----PRP
D
H
T
Q
--------
A
L
A
D
F
A
L
D
M
T
N
V
A
A
Q
LKDPRGNPV
P
L
R
V
GLATG
P
V
V
A
G
VVGS
R
R
F
F
Y
D
V
WG
D
A
V
N
V
A
S
R
MESTDSVGQIQV
P
D
E
V
Y
------
E
R
L
K
D
------
D
F
V
LRE--R
G
H
I
N
V
KGK----
G
V
-
M
R
T
W
Y
L
IGRKVAADPGEVRGAEPRTAGV
2
PsiBlast_PDB
96.56
98%
-124
- C6 -
4P2F
20
CYA1_MYCTU
A:
[67-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
E
R
N
I
I
A
D
K
Y
D
E
A
S
V
L
F
A
D
I
V
G
F
----
T
E
R
A
S
S
T
---
A
----
P
A
D
L
V
R
F
L
D
R
L
Y
S
A
F
D
E
L
V
D
Q
---
H
G
---
L
E
K
I
K
V
S
G
D
S
Y
M
V
V
S
G
V
P
R
----
P
R
P
D
H
T
Q
--------
A
L
A
D
F
A
L
D
M
T
N
V
A
A
Q
L
K
D
P
R
G
N
P
V
P
L
R
V
G
L
A
T
G
P
V
V
A
G
V
V
G
S
R
R
F
R
Y
D
V
W
G
D
A
V
N
V
A
S
R
M
E
S
T
D
S
V
G
Q
I
Q
V
P
D
E
V
Y
------
E
R
L
K
D
------
D
F
V
L
R
E
--
R
G
H
I
N
V
K
G
K
----
G
V
-
M
R
T
W
Y
L
I
G
R
K
------------------
50
HHSearch
96.14
96%
-124
- C6 -
4P2F
20
CYA1_MYCTU
A:
[67-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
E
R
N
I
I
A
D
K
Y
D
E
A
S
V
L
F
A
D
I
V
G
F
----
T
E
R
A
S
S
T
---
A
----
P
A
D
L
V
R
F
L
D
R
L
Y
S
A
F
D
E
L
V
D
Q
---
H
G
---
L
E
K
I
K
V
S
G
D
S
Y
M
V
V
S
G
V
P
R
----
P
R
P
D
H
T
Q
--------
A
L
A
D
F
A
L
D
M
T
N
V
A
A
Q
L
K
D
P
R
G
N
P
V
P
L
R
V
G
L
A
T
G
P
V
V
A
G
V
V
G
S
R
R
F
R
Y
D
V
W
G
D
A
V
N
V
A
S
R
M
E
S
T
D
S
V
G
Q
I
Q
V
P
D
E
V
Y
------
E
R
L
K
D
------
D
F
V
L
R
E
--
R
G
H
I
N
V
K
G
K
----
G
V
-
M
R
T
W
Y
L
I
G
R
K
------------------
3
PsiBlast_PDB
87.37
98%
-103
- C6 -
1YK9
-
CYA1_MYCTU
A:
[245-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
Y
D
E
A
S
V
L
F
A
D
I
V
G
F
----
T
E
R
A
S
S
T
---
A
----
P
A
D
L
V
R
F
L
D
R
L
Y
S
A
F
D
E
L
V
D
Q
---
H
G
---
L
E
K
I
E
V
S
G
D
S
Y
M
V
V
S
G
V
P
R
----
P
R
P
D
H
T
Q
--------
A
L
A
D
F
A
L
D
M
T
N
V
A
A
Q
L
K
D
P
R
G
N
P
V
P
L
R
V
G
L
A
T
G
P
V
V
A
G
V
V
G
S
R
R
F
R
Y
C
V
W
G
D
A
V
N
V
A
S
R
M
E
S
T
D
S
V
G
Q
I
Q
V
P
D
E
V
Y
------
E
R
L
K
D
------
D
F
V
L
R
E
--
R
G
H
I
N
V
K
G
K
----
G
V
-
M
R
T
W
Y
L
I
G
R
K
V
A
A
---------------
21
PsiBlast_CBE
87.06
98%
-121
- C6 -
4P2X
4
CYA1_MYCTU
B:
[53-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
N
I
I
A
D
K
Y
D
E
A
S
V
L
F
A
D
I
V
--------------------------
R
F
L
D
R
L
Y
S
A
F
D
E
L
V
D
Q
---
H
G
---
L
E
K
I
K
V
S
G
D
S
Y
M
V
V
S
G
V
P
R
----
P
R
P
D
H
T
Q
--------
A
L
A
D
F
A
L
D
M
T
N
V
A
A
Q
L
K
D
-
R
G
N
P
V
P
L
R
V
G
L
A
T
G
P
V
V
A
G
V
V
G
S
R
R
F
F
Y
D
V
W
G
D
A
V
N
V
A
S
R
M
E
S
T
--
V
G
Q
I
Q
V
P
D
E
V
Y
------
E
R
L
K
D
------
D
F
V
L
R
E
--
R
G
H
I
N
V
K
G
K
----
G
V
-
M
R
T
W
Y
L
I
G
R
K
V
A
A
---------------
1
PsiBlast_PDB
82.60
100%
-135
- C6 -
4P2M
7
CYA1_MYCTU
A:
[31-217]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
I
A
D
K
Y
D
E
A
S
V
L
F
A
D
I
V
-------------------------
V
R
F
L
D
R
L
Y
S
A
F
D
E
L
V
D
Q
---
H
G
---
L
E
K
I
K
V
S
G
D
S
Y
M
V
V
S
G
V
P
R
----
P
R
P
D
H
T
Q
--------
A
L
A
D
F
A
L
D
M
T
N
V
A
A
Q
L
-
D
P
R
G
N
-
V
P
L
R
V
G
L
A
T
G
P
V
V
A
G
V
V
G
S
R
R
F
F
Y
D
V
W
G
D
A
V
N
V
A
S
R
M
E
S
T
D
S
V
G
Q
I
Q
V
P
D
E
V
Y
------
E
R
L
K
D
------
D
F
V
L
R
E
--
R
G
H
I
N
V
K
G
------
V
-
M
R
T
W
Y
L
I
G
R
K
V
-----------------
59
HHSearch
76.86
37%
-106
- C6 -
2WZ1
2
GCYB1_HUMAN
A:
[8-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
Y
D
N
V
T
I
L
F
S
G
I
V
G
F
----
N
A
F
C
S
K
H
ASG-----
A
M
K
I
V
N
L
L
N
D
L
Y
T
R
F
D
T
L
T
D
S
---
R
K
NPF
V
Y
K
V
E
T
V
G
D
K
Y
M
T
V
S
G
L
P
E
----
P
C
I
H
H
A
R
--------
S
I
C
H
L
A
L
D
M
M
E
I
A
G
Q
V
Q
V
-
D
G
E
S
V
Q
I
T
I
G
I
H
T
G
E
V
V
T
G
V
I
G
Q
R
M
P
R
Y
C
L
F
G
N
T
V
N
L
T
S
R
T
E
T
T
G
E
K
G
K
I
N
V
S
E
Y
T
Y
------
R
C
L
M
S
PENSDP
Q
F
H
L
E
H
--
R
G
P
V
S
M
K
G
K
K---
E
P
-
M
Q
V
W
F
L
S
R
K
N
T
G
----------------
22
PsiBlast_CBE
74.01
34%
-106
- C6 -
2WZ1
1
B:
[5-201]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
A
K
R
Y
D
N
V
T
I
L
F
S
G
I
V
G
F
N
A
F
C
S
K
H
A
S
-
E
---
G
----
A
M
K
I
V
N
L
L
N
D
L
Y
T
R
F
D
T
L
T
D
S
---
R
K
NPF
V
Y
K
V
E
T
V
G
D
K
Y
M
T
V
S
G
L
P
E
----
P
C
I
H
H
A
R
--------
S
I
C
H
L
A
L
D
M
M
E
I
A
G
Q
V
Q
-
V
D
G
E
S
V
Q
I
T
I
G
I
H
T
G
E
V
V
T
G
V
I
G
Q
R
M
P
R
Y
C
L
F
G
N
T
V
N
L
T
S
R
T
E
T
T
G
E
K
G
K
I
N
V
S
E
Y
T
Y
R
C
L
M
SP
E
N
S
D
P
------
Q
F
H
L
E
H
--
R
G
P
V
S
M
K
G
K
----
K
E
P
M
Q
V
W
F
L
S
R
K
N
------------------
6
PsiBlast_PDB
73.57
35%
-103
- C6 -
1CS4
5
A:
[25-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
4
PsiBlast_PDB
73.55
36%
-101
- C6 -
4NI2
6
B:
[5-202]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
P
A
K
R
Y
D
N
V
T
I
L
F
S
G
I
V
G
F
N
A
F
C
S
K
H
A
S
G
E
---
G
----
A
M
K
I
V
N
L
L
N
D
L
Y
T
R
F
D
T
L
T
D
S
---
R
K
NPF
V
Y
K
V
E
T
V
G
D
K
Y
M
T
V
S
G
L
P
E
----
P
C
I
H
H
A
R
--------
S
I
C
H
L
A
L
D
M
M
E
I
A
G
Q
V
Q
-
V
D
G
E
S
V
Q
I
T
I
G
I
H
T
G
E
V
V
T
G
V
I
G
Q
R
M
P
R
Y
C
L
F
G
N
T
V
N
L
T
S
R
T
E
T
T
G
E
K
G
K
I
N
V
S
E
Y
T
Y
R
C
L
M
SP
E
N
S
D
P
------
Q
F
H
L
E
H
--
R
G
P
V
S
M
K
G
K
----
K
E
P
M
Q
V
W
F
L
-
S
R
K
N
-----------------
24
PsiBlast_CBE
73.49
34%
-99
- C6 -
3UVJ
2
D:
[6-201]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
A
K
R
Y
D
N
V
T
I
L
F
S
G
I
V
G
F
N
A
F
C
S
K
H
A
S
G
E
---
G
----
A
M
K
I
V
N
L
L
N
D
L
Y
T
R
F
D
T
L
T
D
S
---
R
K
NPF
V
Y
K
V
E
T
V
C
D
K
Y
M
T
V
S
G
L
P
E
----
P
C
I
H
H
A
R
--------
S
I
C
H
L
A
L
D
M
M
E
I
A
G
Q
V
Q
-
V
D
G
E
S
V
Q
I
T
I
G
I
H
T
G
E
V
V
T
G
V
I
G
Q
R
M
P
R
Y
S
L
F
G
N
T
V
N
L
T
S
R
T
E
T
T
G
E
K
G
K
I
N
V
S
E
Y
T
Y
R
C
L
M
SP
E
N
S
D
P
------
Q
F
H
L
E
H
--
R
G
P
V
S
M
K
G
K
----
K
E
P
M
Q
V
W
F
L
S
R
K
-------------------
25
PsiBlast_CBE
73.45
34%
-95
- C6 -
3UVJ
2
GCYB1_HUMAN
B:
[7-202]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
K
R
Y
D
N
V
T
I
L
F
S
G
I
V
G
F
N
A
F
C
S
K
H
A
S
G
E
---
G
----
A
M
K
I
V
N
L
L
N
D
L
Y
T
R
F
D
T
L
T
D
S
---
R
K
NPF
V
Y
K
V
E
T
V
C
D
K
Y
M
T
V
S
G
L
P
E
----
P
C
I
H
H
A
R
--------
S
I
C
H
L
A
L
D
M
M
E
I
A
G
Q
V
Q
-
V
D
G
E
S
V
Q
I
T
I
G
I
H
T
G
E
V
V
T
G
V
I
G
Q
R
M
P
R
Y
S
L
F
G
N
T
V
N
L
T
S
R
T
E
T
T
G
E
K
G
K
I
N
V
S
E
Y
T
Y
R
C
L
M
SP
E
N
S
D
P
------
Q
F
H
L
E
H
--
R
G
P
V
S
M
K
G
K
----
K
E
P
M
Q
V
W
F
L
S
R
K
N
------------------
33
PsiBlast_CBE
73.36
34%
-106
- C6 -
2GVD
2
B:
[10-206]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
K
E
F
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
I----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
5
PsiBlast_PDB
73.28
34%
-104
- C6 -
2WZ1
2
GCYB1_HUMAN
A:
[5-203]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
A
K
R
Y
D
N
V
T
I
L
F
S
G
I
V
G
F
N
A
F
C
S
K
H
A
S
G
---------
A
M
K
I
V
N
L
L
N
D
L
Y
T
R
F
D
T
L
T
D
S
---
R
K
NPF
V
Y
K
V
E
T
V
G
D
K
Y
M
T
V
S
G
L
P
E
----
P
C
I
H
H
A
R
--------
S
I
C
H
L
A
L
D
M
M
E
I
A
G
Q
V
Q
-
V
D
G
E
S
V
Q
I
T
I
G
I
H
T
G
E
V
V
T
G
V
I
G
Q
R
M
P
R
Y
C
L
F
G
N
T
V
N
L
T
S
R
T
E
T
T
G
E
K
G
K
I
N
V
S
E
Y
T
Y
R
C
L
M
SP
E
N
S
D
P
------
Q
F
H
L
E
H
--
R
G
P
V
S
M
K
G
K
----
K
E
P
M
Q
V
W
F
L
S
R
K
N
T
G
----------------
17
PsiBlast_PDB
73.26
35%
-103
- C6 -
1CJU
4
A:
[17-177]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
7
PsiBlast_PDB
72.99
35%
-93
- C6 -
1U0H
4
A:
[25-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
31
PsiBlast_CBE
72.96
34%
-101
- C6 -
3C14
2
B:
[10-206]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
KEF
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
I----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
42
PsiBlast_CBE
72.72
34%
-108
- C6 -
1AZS
1
B:
[10-206]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
KEF
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
I----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
36
PsiBlast_CBE
72.69
35%
-107
- C6 -
1CUL
4
B:
[9-202]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
KEF
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
-----------ERQY
M
H
I
G
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
15
PsiBlast_PDB
72.62
35%
-104
- C6 -
1CJK
5
A:
[17-177]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
41
PsiBlast_CBE
72.56
34%
-110
- C6 -
1CJK
2
B:
[8-206]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
KEF
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
-----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
16
PsiBlast_PDB
72.55
35%
-101
- C6 -
1CJT
5
A:
[17-177]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
40
PsiBlast_CBE
72.54
34%
-106
- C6 -
1CJT
2
B:
[9-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
KEF
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
-----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
38
PsiBlast_CBE
72.40
34%
-112
- C6 -
1CJV
2
B:
[10-206]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
KEF
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
-----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
28
PsiBlast_CBE
72.30
34%
-106
- C6 -
3G82
2
B:
[10-206]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
K
E
F
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
I----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
51
HHSearch
72.24
33%
-86
- C6 -
1AZS
1
A:
[30-210]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
E
V
E
P
GC
G
G
E
R
N
A
Y
L
K
E
---
H
S
-
I
E
T
F
L
I
L
---------------------
18
PsiBlast_PDB
72.14
35%
-105
- C6 -
1CJV
5
A:
[17-177]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
37
PsiBlast_CBE
72.05
34%
-108
- C6 -
1CS4
4
B:
[9-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
KEF
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
I----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
34
PsiBlast_CBE
71.96
34%
-109
- C6 -
1U0H
2
B:
[10-206]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
K
E
F
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
I----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
30
PsiBlast_CBE
71.83
34%
-109
- C6 -
3C15
2
B:
[10-206]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
K
E
F
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
I----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
19
PsiBlast_PDB
71.83
35%
-105
- C6 -
1CUL
5
A:
[17-177]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
35
PsiBlast_CBE
71.79
34%
-100
- C6 -
1TL7
2
B:
[10-206]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
K
E
F
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
I----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
27
PsiBlast_CBE
71.78
34%
-109
- C6 -
3MAA
2
B:
[10-206]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
KEFY
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
-----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
32
PsiBlast_CBE
71.74
34%
-98
- C6 -
2GVZ
2
B:
[11-206]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
KEFY
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
I----------RQYM
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
13
PsiBlast_PDB
71.61
35%
-99
- C6 -
3G82
4
A:
[25-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
14
PsiBlast_PDB
71.56
35%
-98
- C6 -
3MAA
3
A:
[25-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
39
PsiBlast_CBE
71.47
34%
-108
- C6 -
1CJU
2
B:
[9-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
K
E
F
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
-----------RQY
M
H
I
G
-
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
29
PsiBlast_CBE
71.44
34%
-104
- C6 -
3C16
2
B:
[10-206]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
K
E
F
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
------------QY
M
H
I
G
--
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--
R
G
I
I
N
V
K
G
K
----
G
D
-
L
K
T
Y
F
V
----------------------
20
PsiBlast_PDB
71.25
35%
-91
- C6 -
1TL7
4
A:
[17-177]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
12
PsiBlast_PDB
71.15
35%
-94
- C6 -
3C16
4
A:
[25-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
10
PsiBlast_PDB
71.15
35%
-91
- C6 -
3C14
3
A:
[25-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
53
HHSearch
71.13
31%
-98
- C6 -
4NI2
3
A:
[9-196]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
F
S
N
V
T
M
L
F
S
D
I
V
G
F
----
T
A
I
C
S
Q
C
---
S
----
P
L
Q
V
I
T
M
L
N
A
L
Y
T
R
F
D
Q
Q
C
G
E
---
L
D
---
V
Y
K
V
E
T
I
G
D
A
Y
C
V
A
G
G
L
H
K
----
E
S
D
T
H
A
V
--------
Q
I
A
L
M
A
L
K
M
M
E
L
S
D
E
V
M
S
P
H
G
E
P
I
K
M
R
I
G
L
H
S
G
S
V
F
A
G
V
V
G
V
K
M
P
R
Y
C
L
F
G
N
N
V
T
L
A
N
K
F
E
S
C
S
V
P
R
K
I
N
V
S
P
T
T
Y
------
R
L
L
K
D
CP----
G
F
V
F
T
P
--
R
S
R
E
E
L
P
P
N
FPSE
I
P
-
G
I
C
H
F
L
D
A
Y
Q
------------------
11
PsiBlast_PDB
70.87
35%
-94
- C6 -
3C15
3
A:
[25-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
8
PsiBlast_PDB
70.87
35%
-93
- C6 -
2GVD
4
A:
[25-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
23
PsiBlast_CBE
70.60
35%
-94
- C6 -
1AZS
1
A:
[25-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
54
HHSearch
70.43
31%
-93
- C6 -
3UVJ
3
GCYA3_HUMAN
A:
[9-196]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
F
S
N
V
T
M
L
F
S
D
I
V
G
F
----
T
A
I
C
S
Q
C
---
S
----
P
L
Q
V
I
T
M
L
N
A
L
Y
T
R
F
D
Q
Q
C
G
E
---
L
D
---
V
Y
K
V
E
T
I
G
D
A
Y
C
V
A
G
G
L
H
K
----
E
S
D
T
H
A
V
--------
Q
I
A
L
M
A
L
K
M
M
E
L
S
D
E
V
M
S
P
H
G
E
P
I
K
M
R
I
G
L
H
S
G
S
V
F
A
G
V
V
G
V
-
M
P
R
Y
C
L
F
G
N
N
V
T
L
A
N
K
F
E
S
C
S
V
P
R
K
I
N
V
S
P
T
T
Y
------
R
L
L
K
D
CP----
G
F
V
F
T
P
--
R
S
R
E
E
L
P
P
N
FPSE
I
P
-
G
I
C
H
F
L
D
A
Y
Q
------------------
9
PsiBlast_PDB
69.97
35%
-90
- C6 -
2GVZ
4
A:
[25-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
I
Y
I
Q
K
H
D
N
V
S
I
L
F
A
D
I
E
G
F
----
T
S
L
A
S
Q
C
---
T
----
A
Q
E
L
V
M
T
L
N
E
L
F
A
R
F
D
K
L
A
A
E
---
N
H
---
C
L
R
I
K
I
L
G
D
C
Y
Y
C
V
S
G
L
P
E
----
A
R
A
D
H
A
H
--------
C
C
V
E
M
G
M
D
M
I
E
A
I
S
L
V
R
E
M
T
G
V
N
V
N
M
R
V
G
I
H
S
G
R
V
H
C
G
V
L
G
L
R
K
W
Q
F
D
V
W
S
N
D
V
T
L
A
N
H
M
E
A
G
G
K
A
G
R
I
H
I
T
K
A
T
L
------
S
Y
L
N
G
------
D
Y
--------------------------------------------------
43
PsiBlast_CBE
69.83
34%
-102
- C6 -
4NI2
3
A:
[9-163]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
K
F
S
N
V
T
M
L
F
S
D
I
V
G
F
----
T
A
I
C
S
Q
C
---
S
----
P
L
Q
V
I
T
M
L
N
A
L
Y
T
R
F
D
Q
Q
C
G
E
---
L
D
---
V
Y
K
V
E
T
I
G
D
A
Y
C
V
A
G
G
L
H
K
----
E
S
D
T
H
A
V
--------
Q
I
A
L
M
A
L
K
M
M
E
L
S
D
E
V
M
S
P
H
G
E
P
I
K
M
R
I
G
L
H
S
G
S
V
F
A
G
V
V
G
V
K
M
P
R
Y
C
L
F
G
N
N
V
T
L
A
N
K
F
E
S
C
S
V
P
R
K
I
N
V
S
P
T
T
Y
------
R
L
L
K
D
----------------------------------------------------------
26
PsiBlast_CBE
68.10
34%
-118
- C6 -
1AB8
2
B:
[5-205]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
--
L
Y
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
KEF
Y
T
E
S
D
V
N
K
---
E
----
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
------------QY
M
H
I
G
--
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
--------------------
T
Y
F
V
----------------------
56
HHSearch
67.57
35%
-116
- C6 -
1AB8
2
ADCY2_RAT
A:
[8-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
Q
S
Y
D
C
V
C
V
M
F
A
S
I
P
D
F
----
K
E
F
Y
T
E
S
---
D
VNKE
G
L
E
C
L
R
L
L
N
E
I
I
A
D
F
D
D
L
L
S
K
PKF
S
G
---
V
E
K
I
K
T
I
G
S
T
Y
M
A
A
T
G
L
S
A
IPSQ-
Q
Y
M
H
I
G
--------
T
M
V
E
F
A
Y
A
L
V
G
K
L
D
A
I
N
K
H
S
F
N
D
F
K
L
R
V
G
I
N
H
G
P
V
I
A
G
V
I
G
A
Q
K
P
Q
Y
D
I
W
G
N
T
V
N
V
A
S
R
M
D
S
T
G
V
L
D
K
I
Q
V
T
E
E
T
S
------
L
I
L
Q
T
L
-----
G
Y
T
C
T
C
----------------------
F
V
N
---------------------
44
PsiBlast_CBE
67.42
33%
-100
- C6 -
3UVJ
3
GCYA3_HUMAN
A:
[7-163]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
K
K
F
S
N
V
T
M
L
F
S
D
I
V
G
F
----
T
A
I
C
S
Q
C
---
S
----
P
L
Q
V
I
T
M
L
N
A
L
Y
T
R
F
D
Q
Q
C
G
E
---
L
D
---
V
Y
K
V
E
T
I
G
D
A
Y
C
V
A
G
G
L
H
K
----
E
S
D
T
H
A
V
--------
Q
I
A
L
M
A
L
K
M
M
E
L
S
D
E
V
M
S
P
H
G
E
P
I
K
M
R
I
G
L
H
S
G
S
V
F
A
G
V
V
G
V
-
M
P
R
Y
C
L
F
G
N
N
V
T
L
A
N
K
F
E
S
C
S
V
P
R
K
I
N
V
S
P
T
T
Y
------
R
L
L
K
D
----------------------------------------------------------