@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1629: (2016-05-03 )
MVTTASAPSEDRAKPTLMLLDGNSLAFRAFYALPAENFKTRGGLTTNAVYGFTAMLINLLRDEAPTHIAAAFDVSRQTFRLQRYPEYKANRSSTPDEFAGQIDITKEVLGALGITVLSEPGFEADDLIATLATQAENEGYRVLVVTGDRDALQLVSDDVTVLYPRKGVSELTRFTPEAVVEKYGLTPRQYPDFAALRGDPSDNLPGIPGVGEKTAAKWIAEYGSLRSLVDNVDAVRGKVGDALRANLASVVRNRELTDLVRDVPLAQTPDTLRLQPWDRDHIHRLFDDLEFRVLRDRLFDTLAAAGGPEVDEGFDVRGGALAPGTVRQWLAEHAGDGRRAGLTVVGTHLPHGGDATAMAVAAADGEGAYLDTATLTPDDDAALAAWLADPAKPKALHEAKAAVHDLAGRGWTLEGVTSDTALAAYLVRPGQRSFTLDDLSLRYLRRELRAETPQQQQLSLLDDDDTDAETIQTTILRARAVIDLADALDAELARIDSTALLGEMELPVQRVLAKMESAGIAVDLPMLTELQSQFGDQIRDAAEAAYGVIGKQINLGSPKQLQVVLFDELGMPKTKRTKTGYTTDADALQSLFDKTGHPFLQHLLAHRDVTRLKVTVDGLLQAVAADGRIHTTFNQTIAATGRLSSTEPNLQNIPIRTDAGRRIRDAFVVGDGYAELMTADYSQIEMRIMAHLSGDEGLIEAFNTGEDLHSFVASRAFGVPIDEVTGELRRRVKAMSYGLAYGLSAYGLSQQLKISTEEANEQMDAYFARFGGVRDYLRAVVERARKDGYTSTVLGRRRYLPELDSSNRQVREAAERAALNAPIQGSAADIIKVAMIQVDKALNEAQLASRMLLQVHDELLFEIAPGERERVEALVRDKMGGAYPLDVPLEVSVGYGRSWDAAAH
Atome Classification :
(95 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340..-.....350.......360.......370.......---380.......390.......400......-.410.......420.......430.......440.......450.......-----460.......470.......480.......490..-.....500.......510.......520.......530.......540.......550.......560.......570.....-.-.--580........590.......600.......610...-....620.-.-.-----.-...630.......640.......650.......660.......670........680.......690....-...700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......--850.......860.-.....-.870.......880..-.....890.......900..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVTTASAPSEDRAK
P
T
L
M
L
L
DGN
S
L
A
F
R
A
F
YALPAENFKTRGGLT
T
N
A
V
Y
G
F
T
A
M
L
I
N
L
L
RDEAPT
H
I
A
A
A
FDVSR
Q
T
F
R
LQRYPEYKANRSS
T
P
D
E
FAGQ
I
D
I
T
K
E
V
L
G
A
L
G
I
T
V
LSEPGF
E
A
D
D
L
I
A
T
L
A
T
QAENEG
Y
R
V
L
V
V
TGD
R
D
A
L
Q
LVSD
D
V
T
V
L
YPRK
G
V
S
E
L
T
RF
T
P
E
A
V
V
E
K
YGLTPRQYPDFAALRGDPSDNLPGIPGV
G
E
K
T
A
A
K
W
I
A
E
Y
G
S
L
R
S
L
V
D
N
V
D
A
V
R
G
KV
G
D
A
L
R
A
N
L
A
S
V
V
RN
R
E
L
T
D
L
V
R
DVPLAQTPD
T
L
RLQPW
D
R
D
H
I
H
R
L
F
D
D
L
E
F
R
V
L
R
D
R
L
F
D
T
L
AAAGGPEVDEGFDVRGGALA
P
G
T
V
R
Q
W
L
A
E
HAGDGRRA
G
L
T
V
-
V
GTHLPHGGDA
T
A
M
A
V
A
AADGE
G
A
Y
L
D
T
A
TLTPD
D
---
D
A
A
L
A
A
W
LADPAK
P
K
A
L
H
E
A
K
A
A
V
H
D
LAG-R
G
W
T
L
EGVTS
D
T
A
L
A
A
Y
L
VRPGQRSF
T
L
D
D
L
S
L
R
Y
L
R
R
E
L
RAETP
Q
Q
Q
Q
L
S-----LLDDDDT
D
A
E
T
I
Q
T
T
I
L
R
A
R
A
V
I
D
L
A
D
A
L
D
A
E
L
A
R-ID
S
T
ALLGEMEL
P
V
Q
R
V
L
A
K
M
ESAG
I
A
VD
L
P
M
L
T
E
L
Q
S
Q
F
G
D
Q
I
R
D
A
A
E
A
A
Y
G
V
IGKQINLGSP
K
Q
L
Q
V
V
L
F
DELGMPKTKRT-K-T--GY-TT
D
A
D
A
L
Q
S
L
F
DKTG
H
P
F
L
Q
H
L
L
AHRD
V
T
R
L
K
V
T
-
V
D
G
L
L
Q
A
V
-A-A-----D-
G
R
I
H
T
T
FN
Q
T
I
AATGRLSSTEPNLQNIPIRTDAGR
R
I
R
D
A
F
V
VGD-
G
Y
A
E
L
M
TA
D
Y
S
Q
I
E
M
R
I
M
AHLSGD
E
-
G
L
I
E
AFNT
G
E
D
L
H
S
F
V
A
S
RAFGV
P
I
D
E
V
T
G
E
L
R
R
R
V
K
A
M
S
Y
G
L
A
Y
G
L
S
AYGLS
Q
Q
L
K
IS
T
E
E
A
N
E
Q
M
D
A
Y
F
A
R
FG
G
V
R
D
Y
L
R
A
V
V
E
R
A
RKDGYT
S
T
VLGRRRYLPELDSS
N
R
Q
V
R
E
A
A
E
R
A
ALNAPIQG
S
A
A
D
I
I
K
V
A
M
I
Q
V
D
K
AL
N
E
A
Q
L
A
S
--
R
M
L
L
Q
V
H
D
E
L
L
FEI-APG
E
R
-
E
R
V
E
A
L
V
R
D
KMGGAYP-LD
V
P
L
E
V
S
VGYGRSWDAAAH
133
HHSearch
89.58
39%
-69
- C6 -
1BGX
-
DPO1_THEAQ
T:
[9-832]
-----------
E
P
K
G
R
V
L
L
V
D
G
H
H
L
A
Y
R
T
F
H
A
L
K
G
--
L
T
T
S
R
G
E
P
V
Q
A
V
Y
G
F
A
K
S
L
L
K
A
L
K
E
-
D
G
D
A
V
I
V
V
F
D
A
K
A
P
S
F
R
H
E
A
Y
G
G
Y
K
A
G
R
A
P
T
P
E
D
F
P
R
Q
L
A
L
I
K
E
L
V
D
L
L
G
L
A
R
L
E
V
P
G
Y
E
A
D
D
V
L
A
S
L
A
K
K
A
E
K
E
G
Y
E
V
R
I
L
T
A
D
K
D
L
Y
Q
L
L
S
D
R
I
H
V
L
H
P
E
G
----
Y
-
L
I
T
P
A
W
L
W
E
K
Y
G
L
R
P
D
Q
W
A
D
Y
R
A
L
T
G
D
E
S
D
N
L
P
G
V
K
G
I
G
E
K
T
A
R
K
L
L
E
E
W
G
S
L
E
A
L
L
K
N
L
D
R
L
K
P
A
I
R
E
K
I
L
A
H
M
D
D
L
K
L
S
W
D
L
A
K
V
R
T
D
L
P
L
E
V
D
F
--
A
K
R
R
E
P
D
R
E
R
L
R
A
F
L
E
R
L
E
F
G
S
L
L
H
E
F
G
L
L
E
S
P
K
A
L
E
--------------
E
A
---
P
W
P
P
--
P
E
G
-
A
F
V
G
F
V
L
S
R
K
-
E
-
P
M
W
A
D
L
L
A
L
A
A
A
R
G
-
G
R
V
H
R
A
P
E
P
-------------
Y
K
A
L
R
--
D
L
K
E
A
R
G
L
L
A
K
D
L
S
V
L
A
L
R
E
G
L
G
L
-
P
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
N
--
T
T
P
E
G
V
A
R
R
Y
G
G
E
----------------------------
W
T
E
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
--
K
R
-
S
T
S
A
A
V
L
E
A
L
R
E
A
--
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
-
H
P
R
-----
T
-
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
--
M
G
A
--
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
-----
A
-
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
E
90
PsiBlast_CBE
84.74
41%
-86
- C5 -
1L3S
10
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
62
PsiBlast_CBE
84.66
41%
-87
- C5 -
2HHV
10
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
82
PsiBlast_CBE
84.46
41%
-85
- C5 -
1NJZ
9
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
118
PsiBlast_CBE
84.42
41%
-83
- C5 -
4DQR
7
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
A
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
11
PsiBlast_PDB
84.42
41%
-87
- C5 -
2Y1J
4
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
S
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
K
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
95
PsiBlast_CBE
84.39
41%
-86
- C5 -
1U48
7
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
114
PsiBlast_CBE
84.38
41%
-84
- C5 -
3HT3
5
?
A:
[32-575]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
P
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
67
PsiBlast_CBE
84.37
41%
-87
- C5 -
4DWI
11
?
A:
[34-577]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
86
PsiBlast_CBE
84.35
41%
-87
- C5 -
1L5U
8
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
74
PsiBlast_CBE
84.33
41%
-87
- C5 -
1NKB
8
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
68
PsiBlast_CBE
84.33
41%
-85
- C5 -
4DSI
11
?
A:
[34-577]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
88
PsiBlast_CBE
84.31
41%
-85
- C5 -
1L3U
8
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
70
PsiBlast_CBE
84.29
41%
-85
- C5 -
1XWL
2
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
73
PsiBlast_CBE
84.27
41%
-85
- C5 -
1NKC
7
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
120
PsiBlast_CBE
84.24
41%
-83
- C5 -
4DQQ
7
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
A
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
97
PsiBlast_CBE
84.23
41%
-85
- C5 -
1U45
7
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
60
PsiBlast_CBE
84.23
41%
-87
- C5 -
2HW3
9
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
71
PsiBlast_CBE
84.22
41%
-84
- C5 -
1XC9
8
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
14
PsiBlast_PDB
84.20
41%
-84
- C5 -
3HP6
4
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGA
K
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
93
PsiBlast_CBE
84.15
41%
-86
- C5 -
1U4B
7
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
66
PsiBlast_CBE
84.11
41%
-84
- C5 -
2HHQ
9
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
83
PsiBlast_CBE
84.09
41%
-86
- C5 -
1NJY
8
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
61
PsiBlast_CBE
84.07
41%
-86
- C5 -
2HHX
8
DPO1_BACCA
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
---------
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
79
PsiBlast_CBE
84.05
41%
-86
- C5 -
1NK5
7
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
16
PsiBlast_PDB
84.02
41%
-85
- C5 -
3EYZ
6
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
77
PsiBlast_CBE
84.00
41%
-85
- C5 -
1NK7
9
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
65
PsiBlast_CBE
83.94
41%
-83
- C5 -
2HHS
8
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
10
PsiBlast_PDB
83.93
41%
-85
- C5 -
2Y1I
4
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
S
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
K
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
106
PsiBlast_CBE
83.91
41%
-84
- C5 -
4DQP
5
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
87
PsiBlast_CBE
83.92
41%
-86
- C5 -
1L3V
8
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
80
PsiBlast_CBE
83.91
41%
-84
- C5 -
1NK4
8
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
26
PsiBlast_CBE
83.88
41%
-85
- C5 -
4F2S
6
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
94
PsiBlast_CBE
83.87
41%
-85
- C5 -
1U49
7
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
99
PsiBlast_CBE
83.85
41%
-88
- C5 -
4DSK
6
?
A:
[32-575]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
--------
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
81
PsiBlast_CBE
83.84
41%
-82
- C5 -
1NK0
8
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
8
PsiBlast_PDB
83.82
41%
-86
- C5 -
2XY6
6
?
A:
[34-577]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
113
PsiBlast_CBE
83.80
41%
-85
- C5 -
3HT3
7
?
D:
[32-575]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
P
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
112
PsiBlast_CBE
83.78
41%
-87
- C5 -
2BDP
6
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
R
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
85
PsiBlast_CBE
83.74
41%
-83
- C5 -
1NJW
8
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
89
PsiBlast_CBE
83.72
41%
-85
- C5 -
1L3T
8
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
84
PsiBlast_CBE
83.70
41%
-83
- C5 -
1NJX
9
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
63
PsiBlast_CBE
83.70
41%
-86
- C5 -
2HHU
10
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
76
PsiBlast_CBE
83.68
41%
-83
- C5 -
1NK8
9
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
75
PsiBlast_CBE
83.67
41%
-86
- C5 -
1NK9
8
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
9
PsiBlast_PDB
83.67
41%
-86
- C5 -
2XY5
8
?
A:
[34-577]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
64
PsiBlast_CBE
83.59
41%
-87
- C5 -
2HHT
10
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
72
PsiBlast_CBE
83.56
41%
-85
- C5 -
1NKE
11
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
53
PsiBlast_CBE
83.54
41%
-81
- C5 -
2HHW
6
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
30
PsiBlast_CBE
83.53
41%
-84
- C5 -
4EZ9
4
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
111
PsiBlast_CBE
83.52
41%
-84
- C5 -
3BDP
5
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
R
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
3
PsiBlast_PDB
83.50
41%
-82
- C5 -
4B9N
9
?
A:
[72-615]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
96
PsiBlast_CBE
83.49
41%
-83
- C5 -
1U47
7
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
12
PsiBlast_PDB
83.47
41%
-87
- C5 -
4UQG
7
?
A:
[32-575]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
28
PsiBlast_CBE
83.45
41%
-85
- C5 -
4F2R
7
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
25
PsiBlast_CBE
83.45
41%
-84
- C5 -
4F3O
5
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
34
PsiBlast_CBE
83.41
41%
-82
- C5 -
4DSF
6
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
23
PsiBlast_CBE
83.37
41%
-82
- C5 -
4F4K
7
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
110
PsiBlast_CBE
83.34
41%
-84
- C5 -
4BDP
6
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
R
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
69
PsiBlast_CBE
83.26
41%
-84
- C5 -
4O0I
10
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
32
PsiBlast_CBE
83.25
41%
-83
- C5 -
4EZ6
4
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
91
PsiBlast_CBE
83.24
41%
-83
- C5 -
1UA1
6
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
13
PsiBlast_PDB
83.22
41%
-83
- C5 -
2XO7
6
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
45
PsiBlast_CBE
83.20
41%
-80
- C5 -
3PV8
6
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
36
PsiBlast_CBE
83.20
41%
-84
- C5 -
4DSE
6
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
5
PsiBlast_PDB
83.20
41%
-86
- C5 -
4B9T
5
?
A:
[72-615]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
38
PsiBlast_CBE
83.16
41%
-80
- C5 -
3TI0
5
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
44
PsiBlast_CBE
83.10
41%
-82
- C5 -
3PX0
5
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
43
PsiBlast_CBE
83.10
41%
-83
- C5 -
3PX4
6
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
6
PsiBlast_PDB
83.06
41%
-84
- C5 -
4B9U
8
?
A:
[72-615]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
92
PsiBlast_CBE
82.94
41%
-85
- C5 -
1UA0
6
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
78
PsiBlast_CBE
82.83
41%
-85
- C5 -
1NK6
7
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
47
PsiBlast_CBE
82.80
41%
-82
- C5 -
3EZ5
7
DPO1_GEOSE
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
7
PsiBlast_PDB
82.61
41%
-83
- C5 -
4B9V
9
?
A:
[72-615]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
46
PsiBlast_CBE
82.59
41%
-82
- C5 -
3EZ5
8
DPO1_GEOSE
D:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
40
PsiBlast_CBE
82.59
41%
-81
- C5 -
3THV
6
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
51
PsiBlast_CBE
82.56
41%
-85
- C5 -
2HVH
7
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
50
PsiBlast_CBE
82.56
41%
-84
- C5 -
2HVH
8
?
D:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
4
PsiBlast_PDB
82.53
41%
-83
- C5 -
4B9S
9
?
A:
[72-615]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
101
PsiBlast_CBE
82.46
41%
-83
- C5 -
4DSJ
4
?
A:
[32-575]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
108
PsiBlast_CBE
82.43
41%
-81
- C5 -
4DQI
5
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
42
PsiBlast_CBE
82.42
41%
-82
- C5 -
3PX6
6
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
49
PsiBlast_CBE
82.41
41%
-81
- C5 -
2HVI
6
?
A:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
98
PsiBlast_CBE
82.12
41%
-81
- C5 -
4DSL
4
?
A:
[32-575]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
48
PsiBlast_CBE
82.08
41%
-82
- C5 -
2HVI
6
?
D:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
52
PsiBlast_CBE
81.73
41%
-81
- C5 -
2HHW
6
?
D:
[33-576]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
115
PsiBlast_CBE
81.47
42%
-80
- C5 -
1LV5
6
DPO1_GEOSE
B:
[58-576]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
54
PsiBlast_CBE
81.25
42%
-83
- C5 -
2XY7
4
?
A:
[58-576]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
R
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
100
PsiBlast_CBE
81.06
41%
-81
- C5 -
4DSJ
2
?
B:
[32-575]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
--------
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
116
PsiBlast_CBE
80.93
42%
-77
- C5 -
1LV5
7
DPO1_GEOSE
A:
[58-576]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAK
R
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
-
R
-
P
-----
D
T
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
21
PsiBlast_CBE
80.27
41%
-82
- C5 -
4F8R
3
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
--------------------------
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
102
PsiBlast_CBE
80.26
41%
-84
- C5 -
4DS5
4
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
--------------------
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
104
PsiBlast_CBE
79.80
41%
-83
- C5 -
4DS4
4
?
D:
[45-588]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
----
L
R
P
E
T
ALA
D
P
Q
F
V
A
W
L
G
D
E
T
K
K
K
S
M
F
D
S
K
R
A
A
V
A
L
K
W
-
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
P
D
E
A
V
Y
G
KGAKR
A
V
P
D
E
P
V
L
A
E
H
L
---
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
-
N
E
Q
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
-
T
--
G
Y
-
S
T
S
A
D
V
L
E
K
L
--
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
-
A
-----
T
-
K
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
I
R
L
E
E
G
R
K
I
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
--------------------
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
E
R
L
Q
A
--
H
L
L
L
Q
V
H
D
E
L
I
L
E
A
-
P
K
E
E
M
-
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
-----
122
PsiBlast_CBE
75.02
47%
-91
- C5 -
4N5S
11
DPO1_THEAQ
A:
[150-551]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
-
T
--
G
K
R
S
T
S
A
A
V
L
E
A
L
--
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
-
H
-
P
R----
T
-
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
E
-
G
W
L
-
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
L
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
--
M
G
A
--
R
M
L
L
Q
V
H
D
E
L
V
L
E
--
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
--
123
Fugue
73.00
36%
-69
- C5 -
3KTQ
5
DPO1_THEAQ
A:
[1-539]
-------------
A
L
E
E
A
P
--------------------
W
P
P
P
----
E
G
A
F
V
G
F
V
L
S
R
K
E
P
M
W
A
-
D
L
L
A
L
A
A
A
R
G
-
G
-
R
V
H
R
A
P
------------
E
P
Y
K
A
L
R
D
L
K
--------
E
A
R
G
L
L
A
K
-
D
L
S
V
L
A
L
R
E
-------
G
L
G
L
P
---
P
G
D
D
P
M
L
L
A
Y
L
L
D
P
S
--
N
T
T
P
E
G
V
A
R
R
Y
-------
G
--
G
E
W
T
E
-----------------------------------------
E
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
-------------------------
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
--
V
L
A
H
M
E
A
T
G
-----------------------------------
V
R
L
---------------------------------------
D
V
A
Y
L
R
A
L
S
L
E
V
A
-
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
-------------------------------------------------------------------------
H
----------------------------------------------------------------------------
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
-
E
-
K
TG
K
R
-
S
T
S
A
A
V
L
E
A
L
R
--
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
-
Y
I
D
---
P
L
-
P
-
D
LIHPR
T
-
G
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
V
R
T
P
L
G
Q
R
I
R
R
A
F
I
A
E
-E-
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
-
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
M
----G
A
R
M
L
L
Q
V
H
D
E
L
V
L
E
A
P-
K
E
R
A
-
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
-P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
-