@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1630: (2016-05-03 )
MPSPTVTSPQVAVNDIGSSEDFLAAIDKTIKYFNDGDIVEGTIVKVDRDEVLLDIGYKTEGVIPARELSIKHDVDPNEVVSVGDEVEALVLTKEDKEGRLILSKKRAQYERAWGTIEALKEKDEAVKGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYIGKEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLNNLQKGTIRKGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVQVGDEVTVEVLDVDMDRERVSLSLKATQEDPWRHFARTHAIGQIVPGKVTKLVPFGAFVRVEEGIEGLVHISELAERHVEVPDQVVAVGDDAMVKVIDIDLERRRISLSLKQANEDYTEEFDPAKYGMADSYDEQGNYIFPEGFDAETNEWLEGFEKQRAEWEARYAEAERRHKMHTAQMEKFAAAEAAGRGADDQSSASSAPSEKTAGGSLASDAQLAALREKLAGSA
Atome Classification :
(20 SA)
.........10........20........30....--....40........50........60........70........80........90........100.......110.......120.......130..-.....140--.-......150.......160.......170.......180.......190.......200......-.210.......220.......-.-230--........240.......250.......260.....--..270.......280........-.290.......300-.........310.-......320.......330.......340.......350.......360.--......370.......380.......390......---.400.......410.......420.......430.......440.......450.......460.......470.......480
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPSPTVTSP
Q
V
A
V
NDIGSS
E
D
F
L
A
A
I
D
K
T
I
K
YFND--GDIV
E
G
T
I
V
K
VDRD
E
V
L
L
DIGYKTEGVIPA
R
E
L
S
I
KHDV
D
P
N
E
V
V
SVGDE
V
E
A
L
V
L
TKEDKEG
R
L
I
L
S
K
K
R
A
Q
Y
E
R
AW
G
T
I
E
A
L
K
E
K
D
E
A
VK
G
T
V
I
E
VV-KG
G
L
I
L
D
I--G-LRGFL
P
A
S
L
V
E
M
R
R
V
RDL
Q
P
Y
IGKEI
E
A
K
I
I
E
LDKNRN
N
V
V
L
S
R
R
A
W
L
E
Q
T
Q
S
E
V
R
S
E
F
L
N
N
L
QK-
G
T
I
R
K
G
V
V
S
S
I
V
-NFG
A
F
V
DL-G-G-V--DG
L
V
H
V
SELSWKHID
H
P
S
E
V
V
QVGD
E
V
T
V
E
V
L
DVDM--DR
E
R
V
S
L
S
L
KATQ--E
D
P
W
R
H
F
A
-
R
T
HAIGQIVPGK---
V
T
K
LVPFGA
F
V
R
V
-
E
E
G
I
E
G
L
V
H
I
S
E
L
A
E
R
H
VEVPD
Q
V
V
AVGD
D
A
M
V
K
V
I
D
IDLE
R
R
R
I
S
L
S
LK--QANE
D
Y
T
EEFDPAKYGMADSYDEQG
N
Y
IFPEGFDA---
E
T
N
E
W
L
E
G
F
E
K
Q
R
A
E
W
E
A
R
Y
A
E
A
E
R
R
H
K
M
H
T
A
Q
M
E
K
F
A
A
A
EAAGRGADDQSSASSAPSEKTAGGSLA
S
D
A
Q
L
A
A
L
R
E
K
LAGSA
48
Fugue
93.35
94%
-73
- C1 -
4NNG
-
RS1_MYCTU
A:
[278-434]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Y
--
F
Q
H
M
R
H
F
A
-
R
T
H
A
I
G
Q
I
V
A
G
K
---
V
T
K
L
V
P
F
G
A
F
V
R
V
-
E
E
G
I
E
G
L
V
H
I
S
E
L
A
E
R
H
V
E
V
P
D
Q
V
V
A
V
G
D
D
A
M
V
K
V
I
D
I
D
L
E
R
R
R
I
S
L
S
L
K
--
Q
A
N
E
D
Y
T
E
E
F
D
P
A
K
Y
G
M
A
D
S
Y
D
E
Q
G
N
Y
I
F
P
E
G
F
D
A
---
E
T
N
E
W
L
E
G
F
E
K
Q
R
A
E
W
E
A
R
Y
A
E
A
E
R
R
H
K
M
H
T
A
Q
M
E
K
-----------------------------------------------
2
PsiBlast_PDB
92.57
100%
-73
- C1 -
4NNK
-
RS1_MYCTU
A:
[285-434]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
F
A
-
R
T
H
A
I
G
Q
I
V
P
G
K
---
V
T
K
L
V
P
F
G
A
F
V
R
V
-
E
E
G
I
E
G
L
V
H
I
S
E
L
A
E
R
H
V
E
V
P
D
Q
V
V
A
V
G
D
D
A
M
V
K
V
I
D
I
D
L
E
R
R
R
I
S
L
S
L
K
--
Q
A
N
E
D
Y
T
E
E
F
D
P
A
K
Y
G
M
A
D
S
Y
D
E
Q
G
N
Y
I
F
P
E
G
F
D
A
---
E
T
N
E
W
L
E
G
F
E
K
Q
R
A
E
W
E
A
R
Y
A
E
A
E
R
R
H
K
M
H
T
A
Q
M
E
K
-----------------------------------------------
3
PsiBlast_PDB
92.21
99%
-77
- C1 -
4NNG
-
RS1_MYCTU
A:
[285-434]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
F
A
-
R
T
H
A
I
G
Q
I
V
A
G
K
---
V
T
K
L
V
P
F
G
A
F
V
R
V
-
E
E
G
I
E
G
L
V
H
I
S
E
L
A
E
R
H
V
E
V
P
D
Q
V
V
A
V
G
D
D
A
M
V
K
V
I
D
I
D
L
E
R
R
R
I
S
L
S
L
K
--
Q
A
N
E
D
Y
T
E
E
F
D
P
A
K
Y
G
M
A
D
S
Y
D
E
Q
G
N
Y
I
F
P
E
G
F
D
A
---
E
T
N
E
W
L
E
G
F
E
K
Q
R
A
E
W
E
A
R
Y
A
E
A
E
R
R
H
K
M
H
T
A
Q
M
E
K
-----------------------------------------------
1
PsiBlast_PDB
89.59
100%
-73
- C1 -
4NNI
2
RS1_MYCTU
A:
[8-161]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
F
A
-
R
T
H
A
I
G
Q
I
V
P
G
K
---
V
T
K
L
V
P
F
G
A
F
V
R
V
-
E
E
G
I
E
G
L
V
H
I
S
E
L
A
E
R
H
V
E
V
P
D
Q
V
V
A
V
G
D
D
A
M
V
K
V
I
D
I
D
L
E
R
R
R
I
S
L
S
L
K
--
Q
A
N
E
D
Y
T
E
E
F
D
P
A
K
Y
G
M
A
D
S
Y
D
E
Q
G
N
Y
I
F
P
E
G
F
D
A
---
E
T
N
E
W
L
E
G
F
E
K
Q
R
A
E
W
E
A
R
Y
A
E
A
E
R
R
H
K
M
H
T
A
Q
M
E
K
F
A
A
A
-------------------------------------------
21
PsiBlast_CBE
88.91
100%
-71
- C1 -
4NNI
2
B:
[8-161]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
F
A
-
R
T
H
A
I
G
Q
I
V
P
G
K
---
V
T
K
L
V
P
F
G
A
F
V
R
V
-
E
E
G
I
E
G
L
V
H
I
S
E
L
A
E
R
H
V
E
V
P
D
Q
V
V
A
V
G
D
D
A
M
V
K
V
I
D
I
D
L
E
R
R
R
I
S
L
S
L
K
--
Q
A
N
E
D
Y
T
E
E
F
D
P
A
K
Y
G
M
A
D
S
Y
D
E
Q
G
N
Y
I
F
P
E
G
F
D
A
---
E
T
N
E
W
L
E
G
F
E
K
Q
R
A
E
W
E
A
R
Y
A
E
A
E
R
R
H
K
M
H
T
A
Q
M
E
K
F
A
A
A
-------------------------------------------
4
PsiBlast_PDB
87.40
96%
-80
- C1 -
4NNH
-
RS1_MYCS2
A:
[285-435]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
F
A
-
R
T
H
A
I
G
Q
I
V
P
G
K
---
V
T
K
L
V
P
F
G
A
F
V
R
V
-
E
E
G
I
E
G
L
V
H
I
S
E
L
S
E
R
---
V
P
D
Q
V
V
Q
V
G
D
D
A
M
V
K
V
I
D
I
D
L
E
R
R
R
I
S
L
S
L
K
--
Q
A
N
E
D
Y
T
E
E
F
D
P
S
K
Y
G
M
A
D
S
Y
D
E
Q
G
N
Y
I
F
P
E
G
F
D
P
---
E
T
N
E
W
L
E
G
F
D
K
Q
R
E
E
W
E
A
R
Y
A
E
A
E
R
R
H
K
M
H
T
A
Q
M
E
K
F
----------------------------------------------
6
PsiBlast_PDB
71.41
100%
-96
- C1 -
5IE8
-
?
A:
[280-368]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--
E
D
P
W
R
H
F
A
-
R
T
H
A
I
G
Q
I
V
P
G
K
---
V
T
K
L
V
P
F
G
A
F
V
R
V
-
E
E
G
I
E
G
L
V
H
I
S
E
L
A
E
R
H
V
E
V
P
D
Q
V
V
A
V
G
D
D
A
M
V
K
V
I
D
I
D
L
E
R
R
R
I
S
L
S
L
K
--
Q
A
N
E
D
--------------------------------------------------------------------------------------------------------------------
22
HHSearch
71.27
47%
-64
- C1 -
4Q7J
-
RS1_ECOLI
D:
[17-179]
-------------------------------
E
T
R
P
--
G
S
I
V
R
G
V
V
V
A
I
D
K
D
V
V
L
V
D
A
G
L
K
S
E
S
A
I
P
A
E
Q
F
K
N
A
---
Q
G
E
L
E
I
Q
V
G
D
E
V
D
V
A
L
D
A
V
E
D
G
F
G
E
T
L
L
S
R
E
K
A
K
R
H
E
A
W
I
T
L
E
K
A
Y
E
D
A
E
T
V
T
G
V
I
N
G
K
V
-
K
G
G
F
T
V
E
L
N-
G
-
I
R
A
F
L
P
G
S
L
V
D
V
R
P
V
R
D
T
L
H
L
E
G
K
E
L
E
F
K
V
I
K
L
D
Q
K
R
N
N
V
V
V
S
R
R
A
V
I
E
S
E
N
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
67.42
43%
-66
- C1 -
4Q7J
-
RS1_ECOLI
D:
[3-179]
-------------------
E
S
F
A
Q
L
F
E
E
S
L
K
E
I
E
T
RP
G
S
I
V
R
G
V
V
V
A
I
D
K
D
V
V
L
V
D
A
G
L
K
S
E
S
A
I
P
A
E
Q
F
--
K
N
A
Q
G
E
L
E
I
-
Q
V
G
D
E
V
D
V
A
L
D
A
V
E
D
G
F
G
E
T
L
L
S
R
E
K
A
K
R
H
E
A
W
I
T
L
E
K
A
Y
E
D
A
E
T
V
T
G
V
I
N
G
K
V
-
K
G
G
F
T
V
E
L
N-
G
-
I
R
A
F
L
P
G
S
L
V
D
V
R
P
V
R
D
T
L
H
L
E
G
K
E
L
E
F
K
V
I
K
L
D
Q
K
R
N
N
V
V
V
S
R
R
A
V
I
E
S
E
N
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.39
44%
-68
- C1 -
4Q7J
-
RS1_ECOLI
D:
[3-179]
-------------------
E
S
F
A
Q
L
F
E
E
S
L
K
E
I
E
T
RP
G
S
I
V
R
G
V
V
V
A
I
D
K
D
V
V
L
V
D
A
G
L
K
S
E
S
A
I
P
A
E
Q
F
K
---
N
A
Q
G
E
L
E
I
Q
V
G
D
E
V
D
V
A
L
D
A
V
E
D
G
F
G
E
T
L
L
S
R
E
K
A
K
R
H
E
A
W
I
T
L
E
K
A
Y
E
D
A
E
T
V
T
G
V
I
N
G
K
V
-
K
G
G
F
T
V
E
L
N-
G
-
I
R
A
F
L
P
G
S
L
V
D
V
R
P
V
R
D
T
L
H
L
E
G
K
E
L
E
F
K
V
I
K
L
D
Q
K
R
N
N
V
V
V
S
R
R
A
V
I
E
S
E
N
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
67.38
40%
-84
- C1 -
4R71
-
RS1_ECOLI
E:
[2-171]
------------------
T
E
S
F
A
Q
L
F
E
E
S
L
K
E
I
E
T
R
P
G
S
I
V
R
G
V
V
V
A
I
D
K
D
V
V
L
V
D
A
G
L
K
S
E
S
A
I
P
A
E
Q
F
K
---
N
A
Q
G
E
L
E
I
Q
V
G
D
E
V
D
V
A
L
D
A
V
E
------
L
L
S
R
E
K
A
K
R
H
E
A
W
I
T
L
E
K
A
Y
E
D
A
E
T
V
T
G
V
I
N
G
K
V
-
K
G
G
F
T
V
E
L
N-
G
-
I
R
A
F
L
P
G
S
L
--------
T
L
H
L
E
G
K
E
L
E
F
K
V
I
K
L
D
Q
K
R
N
N
V
V
V
S
R
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
66.17
34%
-60
- C1 -
4NNG
-
RS1_MYCTU
A:
[282-419]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
M
R
H
F
A
R
T
H
A
I
-
G
Q
I
V
A
G
K
V
T
K
L
V
-
P
F
G
A
F
V
R
V
-
E
E
G
-
I
--
E
G
L
V
H
I
S
E
L
A
E
R
H
V
E
V
P
D
Q
V
V
A
V
G
D
D
A
M
V
K
V
I
D
I
D
L
--
E
R
R
R
I
S
L
S
L
K
Q
A
N
--
E
D
Y
T
E
E
F
D
P
A
K
Y
G
M
A
D
S
Y
D
E
Q
---
G
N
Y
I
F
P
E
G
F
D
A
E
T
-
N
E
W
L
E
G
F
E
K
Q
R
A
E
W
E
A
R
Y
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
60.15
50%
-63
- C1 -
3BZK
-
?
A:
[647-726]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
D
L
K
P
-
G
M
V
L
E
G
V
V
T
N
V
T
-
N
F
G
A
F
V
D
I
-
G
V
H
-
Q
--
D
G
L
V
H
I
S
A
L
S
E
K
F
V
K
D
P
Y
E
V
V
K
A
G
D
I
V
K
V
K
V
M
E
V
D
I
--
P
R
N
R
V
G
L
S
M
R
M
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
57.08
50%
-74
- C1 -
2OCE
-
?
A:
[647-726]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
D
L
K
P
-
G
M
V
L
E
G
V
V
T
N
V
T
-
N
F
G
A
F
V
D
I
-
G
V
H
-
Q
--
D
G
L
V
H
I
S
A
L
S
E
K
F
V
K
D
P
Y
E
V
V
K
A
G
D
I
V
K
V
K
V
M
E
V
D
I
--
P
R
N
R
V
G
L
S
M
R
M
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
56.45
21%
-60
- C1 -
3GO5
8
?
A:
[4-224]
-------------------------------------------------------------------------------------------------------------------------
T
N
L
A
S
F
I
V
G
L
I
I
D
E
N
-
D
R
F
Y
F
V
Q
K
D-
G
-
Q
T
Y
A
L
A
K
E
E
G
Q
--------
H
T
V
G
D
T
V
K
G
F
A
Y
T
-
D
M
-
K
Q
K
L
R
L
T
T
L
E
V
--------------
T
A
T
Q
-
D
Q
F
G
W
G
R
V
T
E
V
R
K
D
L
G
V
F
V
D
T
-
G
L
P
D
K
--
E
I
V
V
S
L
D
I
L
P
-
E
L
---
K
E
L
W
P
K
K
G
D
Q
L
Y
I
R
L
-
E
V
D
K
---
K
D
R
I
W
G
L
L
A
Y
Q
E
D
F
Q
R
L
A
R
P
A
--
Y
N
N
M
Q
N
Q
N
W
P
A
I
---
V
Y
R
L
K
L
S
G
T
F
V
Y
L
P
E
N
N
M
L
G
F
I
H
P
S
E
R
Y
A
--------
E
P
R
L
G
Q
V
L
D
A
R
V
I
G
F
R
E
V
D
R
T
L
N
L
S
L
K
--
P
R
S
F
E
M
L
E
N
----------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
55.53
50%
-63
- C1 -
3BZC
-
?
A:
[647-726]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
D
L
K
P
-
G
M
V
L
E
G
V
V
T
N
V
T
-
N
F
G
A
F
V
D
I
-
G
V
H
-
Q
--
D
G
L
V
H
I
S
A
L
S
E
K
F
V
K
D
P
Y
E
V
V
K
A
G
D
I
V
K
V
K
V
M
E
V
D
I
--
P
R
N
R
V
G
L
S
M
R
M
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
54.43
37%
-52
- C1 -
2K4K
-
GS13_BACSU
A:
[7-120]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
S
V
Y
T
G
K
---
V
T
G
L
Q
A
Y
G
A
F
V
A
L
-
D
E
E
T
Q
G
L
V
H
I
S
E
V
T
H
G
F
V
K
D
I
N
E
H
L
S
V
G
D
E
V
Q
V
K
V
L
A
V
D
E
E
K
G
K
I
S
L
S
I
R
A
T
Q
A
A
P
E
-
K
K
E
S
K
P
R
K
P
K
A
A
Q
V
S
E
E
A
S
T
---
P
Q
G
F
N
T
L
K
D
K
L
E
E
W
I
E
----------------------------------------------------------------------------
16
PsiBlast_PDB
52.87
39%
-46
- C1 -
2CQO
-
NO40_HUMAN
A:
[5-92]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
E
T
M
E
N
L
P
A
L
Y
T
I
F
Q
G
E
V
A
M
V
T
-
D
Y
G
A
F
I
K
I
-
P
-
G
-
C
R
K
Q
G
L
V
H
R
T
H
M
S
S
C
R
V
D
K
P
S
E
I
V
D
V
G
D
K
V
W
V
K
L
I
G
R
E
M
K
N
D
R
I
K
V
S
L
S
M
K
V
V
N
--
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
51.55
19%
-42
- C1 -
3GO5
8
?
A:
[3-224]
-------------------------------
N
T
N
L
--
A
S
F
I
V
G
L
I
I
D
E
N
D
R
F
Y
F
V
Q
K
D
-
G
Q
T
Y
A
L
A
K
E
E
G
----------
Q
H
T
V
G
D
T
V
K
G
F
A
Y
T
-
D
M
-
K
Q
K
L
R
L
T
T
L
E
V
T
-----------
A
T
Q
D
Q
F
G
W
G
R
V
T
E
V
R
K
D
L
G
V
F
V
D
T
GL
P
D
K
E
I
V
V
S
L
D
I
L
P
-
E
L
-
K
E
L
W
P
K
K
G
D
Q
L
Y
I
R
L
-
E
V
D
K
-
K
D
R
I
W
G
L
L
A
Y
Q
E
D
F
Q
--
R
L
A
R
P
A
-
Y
N
N
M
Q
-
N
Q
N
W
P
A
I
V
Y
R
L
K
-
L
S
G
T
F
V
Y
L
P
E
N
N
-
M
--
L
G
F
I
H
P
S
E
R
Y
A
--------
E
P
R
L
G
Q
V
L
D
A
R
V
I
G
F
R
E
--
V
D
R
T
L
N
L
S
L
K
P
R
S
--
F
E
M
L
E
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
50.54
32%
-58
- C1 -
2K4K
-
GS13_BACSU
A:
[3-123]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
F
E
V
-
G
S
V
Y
T
G
K
V
T
G
L
Q
-
A
Y
G
A
F
V
A
L
-
D
E
E
-
T
--
Q
G
L
V
H
I
S
E
V
T
H
G
F
V
K
D
I
N
E
H
L
S
V
G
D
E
V
Q
V
K
V
L
A
V
D
E
--
E
K
G
K
I
S
L
S
I
R
A
T
Q
--
A
A
P
E
K
K
E
S
-
K
P
----
R
K
P
K
A
A
QVS
E
E
A
S
T
P
Q
G
-
F
N
T
L
-
K
D
K
L
E
E
W
I
E
M
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------