@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1640c: (2016-05-03 )
MGLHLTVPGLRRDGRGVQSNSHDTSSKTTADISRCPQHTDAGLQRAATPGISRLLGISSRSVTLTKPRSATRGNSRYHWVPAAAGWTVGVIATLSLLASVSPLIRWIIKVPREFINDYLFNFPDTNFAWSFVLALLAAALTARKRIAWLVLLANMVLAAVVNAAEIAAGGNTAAESFGENLGFAVHVVAIVVLVLGYREFWAKVRRGALFRAAAVWLAGAVVGIVASWGLVELFPGSLAPDERLGYAANRVVGFALADPDLFTGRPHVFLNAIFGLFGAFALIGAAIVLFLSQRADNALTGEDESAIRGLLDLYGKDDSLGYFATRRDKSVVFASSGRACITYRVEVGVCLASGDPVGDHRAWPQAVDAWLRLCQTYGWAPGVMGASSQGAQTYREAGLTALELGDEAILRPADFKLSGPEMRGVRQAVTRARRAGLTVRIRRHRDIAEDEMAQTITRADSWRDTETERGFSMALGRLGDPADSDCLLVEAIDPHNQVLAMLSLVPWGTTGVSLDLMRRSPQSPNGTIELMVSELALHAESLGITRISLNFAVFRAAFEQGAQLGAGPVARLWRGLLVFFSRWWQLETLYRSNMKYQPEWVPRYACYEDARVIPRVGVASVIAEGFLVLPFSRRNRVHTGHHPAVPERLAATGLLHHDGSAPDVSGLRQVGLTNGDGVERRLPEQVRVRFDKLEKLRSSGIDAFPVGRPPSHTVAQALAADHQASVSVSGRIMRIRNYGGVLFAQLRDWSGEMQVLLDNSRLDQGCAADFNAATDLGDLVEMTGHMGASKTGTPSLIVSGWRLIGKCLRPLPNKWKGLLDPEARVRTRYLDLAVNAESRALITARSSVLRAVRETLFAKGFVEVETPILQQLHGGATARPFVTHINTYSMDLFLRIAPELYLKRLCVGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYLEWIDGCRELIQNAAQAANGAPIAMRPRTDKGSDGTRHHLEPVDISGIWPVRTVHDAISEALGERIDADTGLTTLRKLCDAAGVPYRTQWDAGAVVLELYEHLVECRTEQPTFYIDFPTSVSPLTRPHRSKRGVAERWDLVAWGIELGTAYSELTDPVEQRRRLQEQSLLAAGGDPEAMELDEDFLQAMEYAMPPTGGLGMGIDRVVMLITGRSIRETLPFPLAKPH
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710......----.----------720--------.-----------...------.---------..--..730.......-740.-.......750.......760-.-.-......770-....-------..---...780.......790..--.....800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960....-..-.970.......980---.......990.......1000........1010--..-.-.------.--..------1020......1030-.----........1040......1050.......1060.....-.1070......1080......1090......1100......1110......1120......1130......1140......1150...-.-.-.1160......1170
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
G
L
H
L
TVPGLRRDGRGVQSNSHDTSSK
T
T
A
D
I
S
RCPQH
T
D
A
G
L
Q
R
AATP
G
I
S
R
L
LGISSR
S
V
T
L
TKPRSATRGNS
R
Y
H
W
V
PAAAGW
T
V
G
V
I
A
T
L
S
L
L
A
S
V
S
P
L
I
R
W
I
I
K
V
P
R
E
F
I
N
D
Y
L
FNFPDT
N
F
A
W
S
F
V
L
A
L
L
A
A
A
L
T
A
R
K
R
I
A
W
L
V
L
L
A
N
M
V
L
A
A
V
V
N
A
A
E
IAAGG
N
T
A
A
E
S
F
G
ENL
G
F
A
V
H
V
V
A
I
V
V
L
V
L
G
Y
R
E
F
W
A
K
V
RR
G
A
L
F
R
A
A
A
V
W
L
A
G
A
V
V
G
I
V
ASW
G
L
V
E
LFPGSLA
P
D
E
R
L
G
Y
A
AN
R
V
V
G
F
A
LADPDLFTGR
P
H
V
F
L
N
A
I
F
G
L
F
G
A
F
A
L
I
G
A
A
I
V
L
F
L
S
QRADNALTGE
D
E
S
A
I
R
G
L
L
D
LYGKDDSL
G
Y
F
A
TRRD
K
S
V
V
F
ASSG
R
A
C
I
T
Y
R
V
E
V
G
V
C
LASGDPVGDHRA
W
P
Q
A
V
D
A
W
L
R
L
C
Q
TYGWAPGVMGASSQ
G
A
Q
T
Y
R
E
AG
L
T
A
LELGDEAILRPADFKLSGP
E
M
R
G
V
R
Q
A
V
T
R
A
R
RA
G
L
T
V
R
I
RRHRDI
A
E
D
E
M
A
Q
T
I
T
R
ADSWRDT
E
T
ER
G
F
S
M
A
LGRLGDPADS
D
C
L
L
V
E
AIDP
H
N
Q
V
L
A
M
L
SLVPWGTTG
V
S
L
D
L
M
RRSPQSPN
G
T
I
E
L
M
V
S
E
L
A
L
H
A
E
SL
G
I
T
R
I
S
L
N
F
A
V
F
R
A
A
F
EQGAQLG
A
G
P
V
A
R
L
W
R
G
L
L
V
F
F
S
R
W
W
Q
L
E
T
L
Y
RSNMKYQPEWV
P
R
YACY
E
D
A
RVIPRV
G
V
A
S
V
I
AEG
F
L
V
L
PFSRRNRVHTGHHPA
V
P
E
R
L
A
A
TGLLHHDGSAP
D
V
S
G
L
R
QVGLTNGD
G
V
E
RRL
P
E
Q
V
R
V
R
F
D
K
L
E
K
L
R
SSGIDAFPVGRPP
S
H
T
V
A
Q
A
L
----
A
----------A----------D-----------HQ
A
------
S
---------
V
S
--VS
G
R
I
M
R
I
RNYG-
G
-
V
L
-
F
A
Q
L
RDWSG
E
M
Q
V
L
L
DNSR--L-D-QGCAADF---NAAT-------
D
L
---
G
D
L
V
E
M
TGHMGASKTGT
P
--
S
L
I
V
S
G
W
R
L
I
G
K
C
L
RPL
P
N
K
W
K
GLLDP
E
A
R
V
R
T
R
Y
L
D
L
A
VNAES
R
A
L
I
T
A
R
S
S
V
L
R
A
V
R
E
T
L
F
AKG
F
V
E
V
E
T
P
I
L
Q
Q
LHGGATAR
P
F
V
T
HINTY
S
M
D
L
F
L
RI
A
P
E
L
Y
L
K
R
L
C
V
G
G
V
E
R
V
F
E
L
G
R
A
F
R
NEGVDFSHNPE
F
T
L
L
E
A
Y
Q
A
H
A
D
Y
L
E
W
I
D
G
C
R
E
L
I
Q
N
A
A
Q
AANGA-
P
I
-
A
MRPRTDKGSDGTR---HHLEPVDISGIW
P
V
R
T
V
H
--
D
A
I
S
E
A
L
G
E
RID---AD-T-
G
------
L
--
T
T
------
L
R
K
L
C
D
AAGVP----Y----RTQWD
A
G
A
V
V
L
E
L
Y
E
H
L
V
E
CR-TEQ
P
T
F
Y
I
DFPTSVSP-LTRP
H
R
SKRG
V
A
E
R
W
D
L
V
A
W
G
I
ELG
T
A
Y
S
E
LT
D
P
V
E
Q
R
R
R
L
Q
E
Q
S
L
LAAGGDP
E
A
M
E
L
D
E
D
F
L
Q
A
M
E
Y
AMPPTGGLGM
G
I
D
R
V
V
M
L
IT-G-R-
S
I
R
E
TLPFPLAKPH
6
PsiBlast_PDB
96.10
39%
-65
- C6 -
3E9H
2
SYK_GEOSE
A:
[5-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
----
E
L
YGDLS
K
E
E
L
E
----------
E
-----------
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
E
L
F
---
K
I
-
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
----------
T
T
K
I
Q
Y
G
E
-----
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
-
S
P
S
I
R
D
V
L
L
F
P
-----
27
PsiBlast_CBE
95.77
39%
-65
- C6 -
3E9H
2
SYK_GEOSE
C:
[5-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
----
E
LYGDLSKEEL
E
----------
E
-----------
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
E
L
F
---
K
I
-
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
----------
T
T
K
I
Q
Y
G
E
-----
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
-
S
P
S
I
R
D
V
L
L
F
P
-----
30
PsiBlast_CBE
95.67
39%
-70
- C6 -
3A74
5
SYK_GEOSE
C:
[5-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
----
E
LYGDLSKEEL
E
----------
E
-----------
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
E
L
F
---
K
I
-
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
----------
T
T
K
I
Q
Y
G
E
-----
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
-
S
P
S
I
R
D
V
L
L
F
P
-----
31
PsiBlast_CBE
95.43
39%
-68
- C6 -
3A74
5
SYK_GEOSE
B:
[5-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
----
E
LYGDLSKEEL
E
----------
E
-----------
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
E
L
F
---
K
I
-
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
----------
T
T
K
I
Q
Y
G
E
-----
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
-
S
P
S
I
R
D
V
L
L
F
P
-----
29
PsiBlast_CBE
95.34
39%
-69
- C6 -
3A74
5
SYK_GEOSE
D:
[5-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
----
E
LYGDLSKEEL
E
----------
E
-----------
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
E
L
F
---
K
I
-
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
----------
T
T
K
I
Q
Y
G
E
-----
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
-
S
P
S
I
R
D
V
L
L
F
P
-----
8
PsiBlast_PDB
95.32
39%
-70
- C6 -
3A74
5
SYK_GEOSE
A:
[5-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
----
E
L
YGDLS
K
E
E
L
E
----------
E
-----------
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
E
L
F
---
K
I
-
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
----------
T
T
K
I
Q
Y
G
E
-----
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
-
S
P
S
I
R
D
V
L
L
F
P
-----
26
PsiBlast_CBE
95.30
39%
-70
- C6 -
3E9H
2
SYK_GEOSE
D:
[5-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
----
E
LYGDLSKEEL
E
----------
E
-----------
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
E
L
F
---
K
I
-
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
----------
T
T
K
I
Q
Y
G
E
-----
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
-
S
P
S
I
R
D
V
L
L
F
P
-----
24
PsiBlast_CBE
95.30
39%
-69
- C6 -
3E9I
4
SYK_GEOSE
C:
[5-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
----
E
LYGDLSKEEL
E
----------
E
-----------
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
E
L
F
---
K
I
-
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
----------
T
T
K
I
Q
Y
G
E
-----
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
-
S
P
S
I
R
D
V
L
L
F
P
-----
7
PsiBlast_PDB
95.23
39%
-65
- C6 -
3E9I
4
SYK_GEOSE
A:
[5-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
----
E
L
YGDLS
K
E
E
L
E
----------
E
-----------
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
E
L
F
---
K
I
-
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
----------
T
T
K
I
Q
Y
G
E
-----
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
-
S
P
S
I
R
D
V
L
L
F
P
-----
54
HHSearch
95.20
40%
-72
- C6 -
3A74
5
SYK_GEOSE
A:
[4-492]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
---------------
E
----------
L
YGDLS
K
E
E
L
E
E
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
-
E
L
---
F
K
I
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
-
T
K
-
I
Q
Y
G
---------------
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
S
P
-
S
I
R
D
V
L
L
F
P
Q
M
R
H
-
56
HHSearch
95.03
41%
-64
- C6 -
1E1O
9
SYK2_ECOLI
A:
[12-502]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
---------------
E
----------
E
FDAKD
N
Q
E
L
E
S
L
N
I
------
E
---------
V
S
--
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
-
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
--
L
-
P
-
E
G
V
Y
N
D
Q
---
F
K
K
W
-------
D
L
---
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
--
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
-
T
K
-
V
T
Y
G
---------------
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
--
E
A
I
K
K
Y
R
P
E
T
D
M
---
A
D
-
L
D
N
------
F
--
D
A
------
A
K
A
L
A
E
S
I
G
I
T
----
V
----
E
K
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
-
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
-
N
S
H
-
T
I
R
D
V
I
L
F
P
A
M
R
P
-
28
PsiBlast_CBE
94.93
39%
-68
- C6 -
3E9H
2
SYK_GEOSE
B:
[5-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
----
E
LYGDLSKEEL
E
----------
E
-----------
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
E
L
F
---
K
I
-
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
----------
T
T
K
I
Q
Y
G
E
-----
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
-
S
P
S
I
R
D
V
L
L
F
P
-----
25
PsiBlast_CBE
94.91
39%
-66
- C6 -
3E9I
4
SYK_GEOSE
B:
[5-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
----
E
LYGDLSKEEL
E
----------
E
-----------
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
E
L
F
---
K
I
-
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
----------
T
T
K
I
Q
Y
G
E
-----
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
-
S
P
S
I
R
D
V
L
L
F
P
-----
23
PsiBlast_CBE
94.67
39%
-68
- C6 -
3E9I
4
SYK_GEOSE
D:
[5-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
----
E
LYGDLSKEEL
E
----------
E
-----------
Q
Q
I
------
E
---------
V
A
--
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
-
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
--
V
-
G
-
E
Q
Q
Y
E
L
F
---
K
I
-
S
-------
D
L
---
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
--
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
----------
T
T
K
I
Q
Y
G
E
-----
H
L
--
V
D
L
T
P
E
W
R
R
L
H
M
V
--
D
A
I
K
E
Y
V
G
V
D
F
W
---
R
Q
-
M
-
S
------
D
--
E
E
------
A
R
E
L
A
K
E
H
G
V
E
----
V
----
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
-
L
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
-
N
-
S
P
S
I
R
D
V
L
L
F
P
-----
2
PsiBlast_PDB
94.28
40%
-62
- C6 -
1E1O
9
SYK2_ECOLI
A:
[16-502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
FD
A
----------
K
----------
D
-----------
N
Q
E
L
E
S
L
N
I
E
---------
V
S
--
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
-
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
--
L
-
P
-
E
G
V
Y
N
D
Q
---
F
K
K
W
-------
D
L
---
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
--
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
----------
T
T
K
V
T
Y
G
-----
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
--
E
A
I
K
K
Y
R
P
E
T
D
M
---
A
D
L
D
-
N
------
F
--
D
A
------
A
K
A
L
A
E
S
I
G
I
T
----
V
----
E
K
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
-
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
-
N
S
H
-
T
I
R
D
V
I
L
F
P
A
M
R
P
-
3
PsiBlast_PDB
94.14
40%
-63
- C6 -
1E1T
11
SYK2_ECOLI
A:
[16-502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
FD
A
----------
K
----------
D
-----------
N
Q
E
L
E
S
L
N
I
E
---------
V
S
--
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
-
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
--
L
-
P
-
E
G
V
Y
N
D
Q
---
F
K
K
W
-------
D
L
---
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
--
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
----------
T
T
K
V
T
Y
G
-----
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
--
E
A
I
K
K
Y
R
P
E
T
D
M
---
A
D
L
D
-
N
------
F
--
D
A
------
A
K
A
L
A
E
S
I
G
I
T
----
V
----
E
K
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
-
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
-
N
S
H
-
T
I
R
D
V
I
L
F
P
A
M
R
P
-
1
PsiBlast_PDB
94.14
40%
-63
- C6 -
1LYL
1
SYK2_ECOLI
A:
[16-502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
FD
A
----------
K
----------
D
-----------
N
Q
E
L
E
S
L
NI
E
---------
V
S
--
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
-
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
--
L
-
P
-
E
G
V
Y
N
D
Q
---
F
K
K
W
-------
D
L
---
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
--
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
----------
T
T
K
V
T
Y
G
-----
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
--
E
A
I
K
K
Y
R
P
E
T
D
M
---
A
D
L
D
-
N
------
F
--
D
A
------
A
K
A
L
A
E
S
I
G
I
T
----
V
----
E
K
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
-
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
-
N
S
H
-
T
I
R
D
V
I
L
F
P
A
M
R
P
-
21
PsiBlast_CBE
94.04
40%
-65
- C6 -
1LYL
1
SYK2_ECOLI
C:
[16-502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
EEFD
A
----------
K
----------
D
-----------
N
Q
E
LESLNI
E
---------
V
S
--
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
-
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
--
L
-
P
-
E
G
V
Y
N
D
Q
---
F
K
K
W
-------
D
L
---
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
--
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
----------
T
T
K
V
T
Y
G
-----
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
--
E
A
I
K
K
Y
R
P
E
T
D
M
---
A
D
L
D
-
N
------
F
--
D
A
------
A
K
A
L
A
E
S
I
G
I
T
----
V
----
E
K
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
-
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
-
N
S
H
-
T
I
R
D
V
I
L
F
P
A
M
R
P
-
5
PsiBlast_PDB
93.77
40%
-65
- C6 -
1E24
7
SYK2_ECOLI
A:
[16-502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
FD
A
----------
K
----------
D
-----------
N
Q
E
L
E
S
L
N
I
E
---------
V
S
--
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
-
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
--
L
-
P
-
E
G
V
Y
N
D
Q
---
F
K
K
W
-------
D
L
---
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
--
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
----------
T
T
K
V
T
Y
G
-----
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
--
E
A
I
K
K
Y
R
P
E
T
D
M
---
A
D
L
D
-
N
------
F
--
D
A
------
A
K
A
L
A
E
S
I
G
I
T
----
V
----
E
K
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
-
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
-
N
S
H
-
T
I
R
D
V
I
L
F
P
A
M
R
P
-
75
Fugue
93.62
41%
-66
- C6 -
1LYL
1
SYK2_ECOLI
A:
[14-502]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
-
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
----
E
----------
E
FDAKD
N
Q
E
L
E
S
-----------
L
N
I
------
E
---------
V
S
--
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
-
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
--DS
L
-
P
-
E
G
V
Y
N
D
Q
---
F
K
K
W
-------
D
L
---
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
--
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
-------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
--------------
T
T
K
V
T
---
Y
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
--
E
A
I
K
K
Y
R
P
E
T
D
M
---
A
D
-
L
D
N
------
F
--
D
A
------
A
K
A
L
A
E
S
I
G
I
T
----
V
----
E
K
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
-
Q
P
T
F
I
T
E
Y
P
A
E
V
S
-P
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
-
N
S
H
-
T
I
R
D
V
I
L
F
P
A
M
R
P
-
9
PsiBlast_PDB
93.57
39%
-63
- C6 -
1BBU
1
SYK1_ECOLI
A:
[14-502]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
E
L
K
T
R
R
E
K
L
A
N
L
R
E
Q
G
I
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
----
A
----------
E
F---------
D
-----------
G
K
E
------
N
E
E
L
E
A
L
N
I
E
V
A
--
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
-
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
D
--
L
-
P
-
E
G
V
Y
N
E
Q
---
F
K
K
W
-------
D
L
---
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
--
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
D
I
L
G
K
-
T
E
-
V
T
Y
------
G
D
V
T
---------
L
D
F
G
K
P
F
E
K
L
T
M
R
--
E
A
I
K
K
Y
R
P
E
T
D
M
---
A
D
L
D
-
N
------
F
--
D
S
------
A
K
A
I
A
E
S
I
G
I
H
----
V
----
E
K
S
W
G
L
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
-
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
Q
R
F
L
D
Q
V
A
A
K
D
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
-
N
S
H
-
T
I
R
D
V
I
L
F
P
A
M
R
P
-
4
PsiBlast_PDB
93.07
40%
-64
- C6 -
1E22
11
SYK2_ECOLI
A:
[16-502]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
FD
A
----------
K
----------
D
-----------
N
Q
E
L
E
S
L
N
I
E
---------
V
S
--
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
-
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
--
L
-
P
-
E
G
V
Y
N
D
Q
---
F
K
K
W
-------
D
L
---
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
--
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
----------
T
T
K
V
T
Y
G
-----
E
H
V
--
F
D
F
G
K
P
F
E
K
L
T
M
R
--
E
A
I
K
K
Y
R
P
E
T
D
M
---
A
D
L
D
-
N
------
F
--
D
A
------
A
K
A
L
A
E
S
I
G
I
T
----
V
----
E
K
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
-
L
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
-
N
S
H
-
T
I
R
D
V
I
L
F
P
A
M
R
P
-
59
HHSearch
92.55
37%
-67
- C6 -
4UP7
1
?
A:
[11-569]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
L
F
L
N
R
C
K
D
V
E
E
Y
Q
K
A
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
---------------
A
----------
K
YSGLEKSQV--
S
D
D
------
I
---------
V
S
--
V
A
G
R
V
L
S
K
R
S
S
S
S
A
-
L
M
-
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
K
S
A
--
Y
-
E
N
K
E
D
F
V
S
L
---
T
K
M
I
-------
Y
R
---
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
--
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
G
-
S
T
K
L
E
I
K
----------FV
T
E
K
K
M
V
L
D
F
T
A
P
F
K
R
I
S
Y
V
--
H
A
L
E
E
K
F
G
E
K
I
P
---
R
P
-
L
-
D
------
G
--
P
E
------
A
L
T
F
L
K
K
Q
A
I
R
F
N
A
I
C
----
A
E
P
Q
T
T
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
-
L
V
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
-
L
A
K
Y
H
R
S
E
P
E
L
T
E
R
F
E
L
F
I
L
K
R
E
I
A
N
A
Y
T
E
L
N
N
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
A
G
D
D
E
A
Q
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
-
D
V
D
-
N
I
K
E
V
I
L
F
P
T
M
R
P
-
55
HHSearch
91.94
40%
-64
- C6 -
4EX5
1
SYK_BURTA
A:
[36-527]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Q
I
V
A
E
R
R
D
K
L
R
A
L
R
D
Q
G
I
A
-
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
---------------
T
----------
A
Y
A
DAD
K
E
A
L
E
A
K
S
L
------
E
---------
V
A
--
I
A
G
R
M
M
L
K
R
V
M
G
-
K
-
A
S
-
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
T
P
A
D
--
V
-
G
-
A
E
T
Y
D
-
A
---
F
K
K
W
-------
D
L
---
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
--
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
------
D
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
G
T
-
A
T
-
I
Q
Y
Q
---------------
G
R
E
L
D
L
A
Q
P
F
H
R
L
T
I
T
--
Q
A
I
Q
K
Y
A
P
S
Y
T
D
---
G
Q
-
L
S
D
------
D
--
A
F
------
L
R
S
E
L
K
R
L
G
V
D
----
V
TQPA
F
L
N
A
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
-
L
W
E
P
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
-
D
S
P
-
T
I
R
D
V
L
L
F
P
H
L
R
R
-
57
HHSearch
91.57
35%
-68
* C6 *
4YCU
4
SYK_HUMAN
A:
[4-507]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
Q
Y
Y
K
I
R
S
Q
A
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
---------------
Q
----------
K
Y
SHLQPGDHL-
T
D
I
------
T
---------
L
K
--
V
A
G
R
I
H
A
K
R
A
S
G
G
K
-
L
I
-
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
--
Y
K
S
-
E
E
E
F
I
H
I
---
N
N
K
L
-------
R
R
---
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
--
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
H
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
G
S
-
Y
K
-
V
T
Y
H
P
D
G
--
P
---
E
---
G
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
--
E
E
L
E
K
A
L
G
M
K
L
P
---
E
T
-
N
-
L
FET
E
E
T
R
--
K
I
------
L
D
D
I
C
V
A
K
A
V
E
----
C
----
P
P
P
R
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
-
C
I
N
P
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
-
D
S
N
-
N
I
K
E
V
L
L
F
P
A
M
K
P
-
36
PsiBlast_CBE
91.55
35%
-70
- C6 -
4YCU
4
SYK_HUMAN
B:
[10-507]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
S
Q
A
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
----
Q
----------
K
Y
SHLQPG---
D
-----------
H
L
T
------
D
---------
I
T
L
K
V
A
G
R
I
H
A
K
R
A
S
G
-
G
K
L
I
-
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
-
N
S
R
----
N
-
Y
K
S
E
E
E
F
I
H
I
N
N
K
L
-------
R
R
---
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
--
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
-----
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
G
S
Y
K
V
-
T
Y
H
P
---
D
G
P
E
G
--------
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
G
M
K
L
P
---
E
T
-
N
-
L
------
F
--
E
T
E
E
T
R
K
I
L
D
D
I
C
V
A
K
A
V
E
----
C
----
P
P
P
R
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
-
C
I
N
P
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
-
N
-
N
I
K
E
V
L
L
F
P
A
M
K
P
-
14
PsiBlast_PDB
91.22
35%
-68
- C6 -
4YCU
4
SYK_HUMAN
A:
[10-507]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
S
Q
A
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
----
Q
----------
K
Y
SHLQPG---
D
-----------
H
L
T
------
D
---------
I
T
L
K
V
A
G
R
I
H
A
K
R
A
S
G
-
G
K
L
I
-
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
-
N
S
R
----
N
-
Y
K
S
E
E
E
F
I
H
I
N
N
K
L
-------
R
R
---
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
--
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
H
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
G
S
Y
K
V
-
T
Y
H
P
---
D
G
P
E
G
--------
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
G
M
K
L
P
---
E
T
-
N
-
L
------
F
--
E
T
E
E
T
R
K
I
L
D
D
I
C
V
A
K
A
V
E
----
C
----
P
P
P
R
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
-
C
I
N
P
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
-
N
-
N
I
K
E
V
L
L
F
P
A
M
K
P
-
11
PsiBlast_PDB
90.38
39%
-65
- C6 -
4EX5
1
SYK_BURTA
A:
[40-523]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
E
R
R
D
K
L
R
A
L
R
D
Q
G
I
-
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
----
T
----------
A
Y
A
DA------
D
-----------
K
E
A
L
E
A
K
S
L
E
---------
V
A
--
I
A
G
R
M
M
L
K
R
V
M
G
-
K
-
A
S
-
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
------------
T
P
A
D
V
---
G
A
E
T
Y
D
A
F
K
K
W
D
L
---
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
--
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
------
D
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
--------------
L
G
T
A
T
I
Q
---
Y
Q
G
R
E
L
D
L
A
Q
P
F
H
R
L
T
I
T
--
Q
A
I
Q
K
Y
A
P
S
Y
T
D
G
Q
L
S
D
-
D
-
A
------
F
L
R
S
E
------
L
K
R
L
G
V
D
V
T
Q
P
----
A
----
F
L
N
A
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
-
L
W
E
P
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
-
D
-
S
P
T
I
R
D
V
L
L
F
P
-----
32
PsiBlast_CBE
89.76
39%
-65
- C6 -
4EX5
1
SYK_BURTA
B:
[40-523]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
E
R
R
D
K
L
R
A
L
R
D
Q
G
I
-
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
----
T
----------
A
Y
A
DA------
D
-----------
K
E
A
L
E
A
K
S
L
E
---------
V
A
--
I
A
G
R
M
M
L
K
R
V
M
G
-
K
-
A
S
-
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
------------
T
P
A
D
V
---
G
A
E
T
Y
D
A
F
K
K
W
D
L
---
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
--
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
-------
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
--------------
L
G
T
A
T
I
Q
---
Y
Q
G
R
E
L
D
L
A
Q
P
F
H
R
L
T
I
T
--
Q
A
I
Q
K
Y
A
P
S
Y
T
D
G
Q
L
S
D
-
D
-
A
------
F
L
R
S
E
------
L
K
R
L
G
V
D
V
T
Q
P
----
A
----
F
L
N
A
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
-
L
W
E
P
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
-
D
-
S
P
T
I
R
D
V
L
L
F
P
-----
20
PsiBlast_PDB
65.41
46%
-46
- C6 -
4UPA
1
?
A:
[62-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
--
V
A
G
R
V
L
S
K
R
S
S
S
-
S
-
A
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
K
S
A
--
Y
-
E
-
N
--
K
E
D
F
---
V
S
L
T
-------
K
M
IYR
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
--
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
65.39
46%
-45
- C6 -
4UP9
1
?
A:
[62-376]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
--
V
A
G
R
V
L
S
K
R
S
S
S
-
S
-
A
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
K
S
A
--
Y
-
E
-
N
--
K
E
D
F
---
V
S
L
T
-------
K
M
IYR
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
--
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
65.37
46%
-42
- C6 -
4UP7
1
?
A:
[62-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
--
V
A
G
R
V
L
S
K
R
S
S
S
-
S
-
A
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
N
K
S
A
--
Y
-
E
-
N
--
K
E
D
F
---
V
S
L
T
-------
K
M
IYR
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
--
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
T
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------