@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1649: (2016-05-03 )
MLSPEALTTAVDAAQQAIALADTLDVLARVKTEHLGDRSPLALARQALAVLPKEQRAEAGKRVNAARNAAQRSYDERLATLRAERDAAVLVAEGIDVTLPSTRVPAGARHPIIMLAEHVADTFIAMGWELAEGPEVETEQFNFDALNFPADHPARGEQDTFYIAPEDSRQLLRTHTSPVQIRTLLARELPVYIISIGRTFRTDELDATHTPIFHQVEGLAVDRGLSMAHLRGTLDAFARAEFGPSARTRIRPHFFPFTEPSAEVDVWFANKIGGAAWVEWGGCGMVHPNVLRATGIDPDLYSGFAFGMGLERTLQFRNGIPDMRDMVEGDVRFSLPFGVGA
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.....--------..130.-.....---------.140.......150.......160.------------...------------.------------..170.......180.....--..190.......200.......210.......220----------------------------------......-----------------------------------..230.......240.......250.......260....-..------.270....------.---...280.......290..-------....--.300-------..-.......310.......320.......330.......340-------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ML
S
P
E
A
L
T
T
A
V
D
A
A
Q
Q
A
I
A
L
A
D
T
L
D
V
L
A
R
V
K
T
E
HLGDR
S
P
L
A
L
A
R
Q
A
L
A
VL
P
K
E
Q
R
A
E
AGKR
V
N
A
A
R
N
A
A
Q
R
S
Y
D
E
R
L
A
T
L
RAER
D
A
A
V
L
V
AEG
I
D
V
TLPSTRVPAGARHP
I
I
M
L
A
E
H
V
A
D
T
F
I
A
MG--------WELAEG-PEVET---------EQFNFDALNFPADHPARGEQ
D
T
F
Y
I------------APE------------D------------
S
R
Q
L
L
R
THTS
P
V
Q
I
R
T
L
L
A
R--EL
P
V
Y
I
I
SIGRTFRTDELDATHT
P
I
F
H
Q
VEGLAV-----------------------------------DRGL
S
M
-----------------------------------
A
H
L
R
G
T
L
D
A
F
A
R
AEFGPSARTRIRPHFFPFTEPSA
E
V
D
V
-
W
F
------AN-KIGG
A
------
A
---
W
V
EWGGCGMVHP
N
V
LRAT-------GI
D
P
--
D
L
---------
Y
S
-
G
F
A
FGM
G
L
E
R
T
L
Q
F
RNGIP
D
M
R
D
M
VEG
D
V
R
F
SLPFGVGA--------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
88.13
39%
-83
- C3 -
1EIY
-
SYFA_THET8
A:
[6-342]
--------------
L
A
A
I
Q
N
A
R
D
L
E
E
L
K
A
L
K
A
R
Y
L
G
K
K
G
L
L
T
Q
E
M
K
G
L
S
A
L
P
L
E
E
R
R
K
R
G
Q
E
L
N
A
I
K
A
A
L
E
A
A
L
E
A
R
E
K
A
L
E
E
A
A
L
K
E
A
L
E
R
E
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
----
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
Y
RG-------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
----------------------------------------------------------------------------------------------------------------
55
Fugue
87.43
41%
-76
- C3 -
1EIY
-
SYFA_THET8
A:
[6-350]
--------------
L
A
A
I
Q
N
A
R
D
L
E
E
L
K
A
L
K
A
R
Y
L
G
K
K
G
L
L
T
Q
E
M
K
G
L
S
A
L
P
L
E
E
R
R
K
R
G
Q
E
L
N
A
I
K
A
A
L
E
A
A
L
E
A
R
E
K
A
L
E
E
A
A
L
K
E
A
L
E
R
E
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
E
G
F
R
L
E
G
PLG
E
E
V
------------
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
-
G
---
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
-------
D
A
Y
R
--
E
R
L
GLPPAYRG
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
--------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
86.18
39%
-83
- C3 -
2IY5
1
SYFA_THETH
A:
[15-342]
-----------------------
L
E
E
L
K
A
L
K
A
R
Y
L
G
K
K
G
L
L
T
Q
E
M
K
G
L
S
A
L
P
L
E
E
R
R
K
R
G
Q
E
L
N
A
I
K
A
A
L
E
A
A
L
E
A
R
E
K
A
L
E
E
A
A
L
K
E
A
L
E
R
E
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
----
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
Y
RG-------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
----------------------------------------------------------------------------------------------------------------
39
HHSearch
85.91
48%
-99
- C3 -
2RHQ
2
SYFA_STAHJ
A:
[33-289]
-----------------------------------------------------------------------------------------
L
A
E
E
T
I
D
V
T
L
P
S
R
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
--------
Y
E
I
V
D
G
-
Y
E
V
E
Q
---------
D
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
------------
T
---------------------------
D
E
I
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
K
R
NG
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
R
D
S
D
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
-----------------------------------
D
K
N
I
K
M
-----------------------------------
S
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
I
R
L
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
-
S
C
FKCKGK
G
C
N
V
C
K
H
T
------
G
---
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
S
--
N
E
---------
Y
S
-
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
L
E
Q
F
K
A
V
---------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
84.19
46%
-86
- C3 -
3PCO
2
SYFA_ECOLI
C:
[5-326]
-------
A
E
L
V
A
S
A
K
A
A
I
S
Q
A
S
D
V
A
A
L
D
N
V
R
V
E
Y
L
G
K
K
G
H
L
T
L
Q
M
T
T
L
R
E
L
P
P
E
E
R
P
A
A
G
A
V
I
N
E
A
K
E
Q
V
Q
Q
A
L
N
A
R
K
A
E
L
E
S
A
A
L
N
A
R
L
A
A
E
T
I
D
V
S
L
P
G
R
R
I
E
N
G
G
L
H
P
V
T
R
T
I
D
R
I
E
S
F
F
G
E
L
G
--------
F
T
V
A
T
G
-
P
E
I
E
D
---------
D
Y
H
N
F
D
A
L
N
I
P
G
H
H
P
A
R
A
D
H
D
T
F
W
F
---------------------------
D
------------
T
T
R
L
L
R
T
Q
T
S
G
V
Q
I
R
T
M
K
A
Q
--
Q
P
P
I
R
I
I
A
P
G
R
V
Y
R
N
D
-
Y
D
Q
T
H
T
P
M
F
H
Q
M
E
G
L
I
V
-----------------------------------
D
T
N
I
S
F
-----------------------------------
T
N
L
K
G
T
L
H
D
F
L
R
N
F
F
E
E
D
L
Q
I
R
F
R
P
S
Y
F
P
F
T
E
P
S
A
E
V
D
V
-
M
G
------
K
N
-----
G
------
K
---
W
L
E
V
L
G
C
G
M
V
H
P
N
V
L
R
N
V
-------
G
I
D
P
--
E
V
---------
Y
S
-
G
F
A
F
G
M
G
M
E
R
L
T
M
L
R
Y
G
V
T
D
L
R
S
F
F
E
N
D
L
R
F
L
K
Q
F
------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
82.93
47%
-99
- C3 -
2RHQ
2
SYFA_STAHJ
A:
[25-282]
---------------------------------------------------------------------------------
L
M
E
K
L
N
Q
Q
L
A
E
E
T
I
D
V
T
L
P
S
R
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
--------
Y
E
I
V
D
G
-
Y
E
V
E
Q
---------
D
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
------------
T
D
E
---------------------------
I
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
K
R
NG
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
R
D
S
D
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
-----------------------------------
D
K
N
I
K
M
-----------------------------------
S
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
I
R
L
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
S
C
F
------
K
C
-
K
G
K
G
C
NVCKHT
G
---
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
S
--
N
E
---------
Y
S
-
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
----------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.86
44%
-98
- C3 -
4P71
-
SYFA_PSEAE
C:
[9-254]
------------------------------------------------------------------------------------------
A
A
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
--------
Y
E
V
A
E
G
-
P
E
V
E
D
---------
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------------------
N
------------
A
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-----------------------------------
D
E
G
V
S
F
-----------------------------------
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
-
Q
C
---------------------QTG
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
K
---------
F
Q
-
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
----------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
81.45
47%
-94
- C3 -
2RHS
2
SYFA_STAHJ
C:
[24-282]
--------------------------------------------------------------------------------
E
L
M
E
K
L
N
Q
Q
L
A
E
E
T
I
D
V
T
L
P
S
R
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
--------
Y
E
I
V
D
G
-
Y
E
V
E
Q
---------
D
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
------------
T
D
E
---------------------------
I
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
K
R
NG
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
R
D
S
D
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
-----------------------------------
D
K
N
I
K
M
-----------------------------------
S
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
I
R
L
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
S
C
F
------
K
C
-
K
G
K
G
C
NVCKHT
G
---
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
S
--
N
E
---------
Y
S
-
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
----------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
81.27
43%
-95
- C3 -
2ALY
2
SYFA_THETH
A:
[2-258]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
----
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
Y
RG-------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
----------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
80.68
43%
-102
- C3 -
2AMC
2
SYFA_THETH
A:
[2-258]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
----
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
Y
RG-------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
----------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.51
44%
-98
- C3 -
4P73
1
SYFA_PSEAE
C:
[88-333]
------------------------------------------------------------------------------------------
A
A
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
--------
Y
E
V
A
E
G
-
P
E
V
E
D
---------
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------------------
N
------------
A
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-----------------------------------
D
E
G
V
S
F
-----------------------------------
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
-
Q
C
---------------------QTG
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
K
---------
F
Q
-
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
----------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
80.48
43%
-98
- C3 -
2AKW
2
SYFA_THETH
A:
[2-258]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
----
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
Y
RG-------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
----------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.29
44%
-98
- C3 -
4P75
1
SYFA_PSEAE
C:
[90-333]
--------------------------------------------------------------------------------------------
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
--------
Y
E
V
A
E
G
-
P
E
V
E
D
---------
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------------------
N
------------
A
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-----------------------------------
D
E
G
V
S
F
-----------------------------------
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
-
Q
C
---------------------G--
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
K
---------
F
Q
-
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
----------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
80.27
39%
-101
- C3 -
1JJC
2
SYFA_THET8
A:
[85-342]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
G
F
R
L
E
G
PLGE
E
V
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
----
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
Y
RG-------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
----------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.21
39%
-103
- C3 -
1PYS
1
SYFA_THET8
A:
[85-342]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
G
F
R
L
E
G
PLGEEV
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
----
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
Y
RG-------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
----------------------------------------------------------------------------------------------------------------
36
HHSearch
79.91
45%
-99
- C3 -
4P72
1
SYFA_PSEAE
C:
[90-338]
--------------------------------------------------------------------------------------------
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
--------
Y
E
V
A
E
G
-
P
E
V
E
D
---------
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
------------
N
---------------------------
A
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-----------------------------------
D
E
G
V
S
F
-----------------------------------
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
-
Q
C
--------------------
G
---
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
K
---------
F
Q
-
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
-----------------------------------------------------------------------------------------------------------
57
Fugue
79.79
30%
-96
- C3 -
3CMQ
2
SYFM_HUMAN
A:
[11-415]
---------------------------------------------------
P
G
S
V
V
E
L
L
G
K
S
Y
P
---
Q
D
D
H
S
N
L
T
R
K
V
L
T
R
------------------
V
G
R
N
L
H
N
Q
Q
H
H
P
L
W
L
I
K
E
R
V
K
E
H
F
Y
K
Q
Y
--------
V
G
R
F
G
T
-
P
L
F
S
V
Y
DNLSPVVT
T
W
Q
N
F
D
S
L
L
I
P
A
D
H
P
S
R
K
K
G
D
N
Y
Y
L
---------------------------
N
------------
R
T
H
M
L
R
A
H
T
S
-
A
H
Q
W
D
L
L
H
A
--
G
L
D
A
F
L
V
-
V
G
D
V
Y
R
R
D
Q
I
D
S
Q
H
Y
P
I
F
H
Q
L
E
A
V
R
L
-----------------------------------
F
S
K
H
E
L
F
AGIKDGESLQL
F
E
Q
S
S
R
S
AHKQETHT
M
E
A
V
K
L
V
E
F
D
L
K
Q
T
L
T
R
L
M
A
H
L
F
G
D
E
L
E
I
R
W
V
D
C
Y
F
P
F
T
H
P
S
F
E
M
E
I
-
N
F
------
H
G
------------
E
---
W
L
E
V
L
G
C
G
V
M
E
Q
Q
L
V
N
S
A
-------
G
A
Q
D
-------------
R
I
-
G
W
A
F
G
L
G
L
E
R
L
A
M
I
L
Y
D
I
P
D
I
R
L
F
W
C
E
D
E
R
F
L
K
Q
F
C
V
S
N
INQKVK
F
Q
P
L
S
K
Y
P
A
V
I
N
D
I
S
F
W
L
P
SENYA
E
N
D
F
Y
D
L
V
R
T
I
GGDLVEKVDLI
D
K
F
V
H
PKTH
K
T
S
H
C
Y
R
I
T
Y
R
H
ME
R
T
L
S
Q
R
E
V
R
H
I
H
Q
A
L
Q
E
A
A
V
Q
LLGVEGRF
22
PsiBlast_CBE
79.58
44%
-94
- C3 -
4P75
1
SYFA_PSEAE
D:
[87-333]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
--------
Y
E
V
A
E
G
-
P
E
V
E
D
---------
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------------------
N
------------
A
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-----------------------------------
D
E
G
V
S
F
-----------------------------------
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
-
Q
C
------
V
I
-
C
S
G
---------G--
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
K
---------
F
Q
-
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
----------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
79.39
39%
-99
- C3 -
3HFZ
1
SYFA_THET8
A:
[85-342]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
----
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
Y
RG-------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
----------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
79.26
44%
-95
- C3 -
4P73
1
SYFA_PSEAE
D:
[87-333]
-----------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
--------
Y
E
V
A
E
G
-
P
E
V
E
D
---------
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
---------------------------
N
------------
A
N
M
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
E
S
Q
--
Q
P
P
I
R
I
V
C
P
G
R
V
Y
R
C
D
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
-----------------------------------
D
E
G
V
S
F
-----------------------------------
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
E
K
Q
L
E
V
R
F
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
-
Q
C
------
V
I
-
C
-----------QTG
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
P
--
E
K
---------
F
Q
-
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
----------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
78.68
39%
-101
- C3 -
4TVA
1
SYFA_THETH
A:
[85-342]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
----
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
Y
RG-------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
----------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
78.62
39%
-103
- C3 -
3TEH
1
SYFA_THETH
A:
[85-342]
---------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
GFRLEGPLG
E
E
V
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
----
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
Y
RG-------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
----------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.19
39%
-96
- C3 -
1B70
2
SYFA_THETH
A:
[86-342]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
----
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
Y
RG-------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
----------------------------------------------------------------------------------------------------------------
37
HHSearch
78.08
42%
-97
- C3 -
1B7Y
2
SYFA_THETH
A:
[86-349]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
------------
G
F
R
L
E
G
PLG
E
E
V
E
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
----
E
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
AY
R
G
---------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
---------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.30
39%
-98
- C3 -
1B7Y
2
SYFA_THETH
A:
[86-342]
----------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
--------
Y
Q
A
V
E
G
-
P
E
V
E
S
---------
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
------------
T
G
E
G
F
R
L
E
G
PLG
E
E
V
E
------------
G
R
L
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
T
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
-----------------------------------
G
E
G
I
A
M
-----------------------------------
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
P
D
S
K
V
R
F
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
-
W
W
------
P
E
----
G
G
------
K
---
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
P
--
A
Y
RG-------
V
T
-
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
----------------------------------------------------------------------------------------------------------------
40
HHSearch
67.07
34%
-97
- C3 -
3CMQ
2
SYFM_HUMAN
A:
[41-307]
------------------------------------------------------------------------------------------------------
N
L
H
N
Q
Q
H
H
P
L
W
L
I
K
E
R
V
K
E
H
F
Y
K
Q
Y
V
G
R
F
GT
P
L
F
S
V
Y
D
N
L
S
P
V
V
T
---------
T
W
Q
N
F
D
S
L
L
I
P
A
D
H
P
S
R
K
K
G
D
N
Y
Y
L
------------
N
R
---------------------------
T
H
M
L
R
A
H
T
S
A
H
Q
W
D
L
L
H
A
----
G
L
D
A
F
L
V
V
G
D
V
Y
R
R
D
Q
I
D
S
Q
H
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H
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AGIKDGESLQL
F
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AHKQETHT
M
E
A
V
K
L
V
E
-----------------------------------
F
D
L
K
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T
L
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M
A
H
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D
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L
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-
N
F
------------
H
G
------
E
---
W
L
E
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L
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C
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M
E
Q
Q
L
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N
S
A
-------
G
A
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--------------
D
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F
------------------------------------------------------------------------------------------------------------