@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1655: (2016-05-03 )
MTGASTTTATMRQRWQAVMMNNYGTPPIALASGDGAVVTDVDGRTYIDLLGGIAVNVLGHRHPAVIEAVTRQMSTLGHTSNLYATEPGIALAEELVALLGADQRTRVFFCNSGAEANEAAFKLSRLTGRTKLVAAHDAFHGRTMGSLALTGQPAKQTPFAPLPGDVTHVGYGDVDALAAAVDDHTAAVFLEPIMGESGVVVPPAGYLAAARDITARRGALLVLDEVQTGMGRTGAFFAHQHDGITPDVVTLAKGLGGGLPIGACLAVGPAAELLTPGLHGSTFGGNPVCAAAALAVLRVLASDGLVRRAEVLGKSLRHGIEALGHPLIDHVRGRGLLLGIALTAPHAKDAEATARDAGYLVNAAAPDVIRLAPPLIIAEAQLDGFVAALPAILDRAVGAP
Atome Classification :
(49 SA)
.........10........20....--....30........40........50........60.........70........80..---.......90........100...-....110.......120....-------.---------.---------.---------130-------.........140.......150..-...----..160.......170.-----------------......180.-.-.----------.--....190........200.......210.......220.......230.......240.......250......-.-260.......270.-....-..280.......290.......300----.......310.......320..-..--.--.--...330.......340--.---...---...---350.-.---.-.---...360....-...370.......380---........390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTGAS
T
T
T
A
T
M
R
Q
R
W
Q
A
V
M
MNNYGT--P
P
I
A
L
ASGD
G
A
V
V
T
DVDG
R
T
Y
I
D
L
L
G
G
I
A
V
N
V
LGH-R
H
P
A
V
I
E
A
V
T
R
Q
M
S
TLGHTS-NL---YATEP
G
I
A
L
A
E
E
L
V
A
L
LGADQ
R
T
-
R
V
F
F
CNSGAEA
N
E
A
A
F
K
L
S
R
L-------T---------G---------R---------
T
---------
K
L
V
A
AHDAFHGRTMG
S
L
A
LTGQPA-KQT----PFAPLPGDVTHVGYG
D
-----------------
V
D
A
L
A
A
A
V-D-D-H----------
T
--
A
A
V
F
L
-
E
P
IMGES
G
V
VVPPA
G
Y
L
A
A
ARDITARR
G
A
L
L
V
L
D
E
V
Q
TGMGRT
G
A
F
F
A
HQHDGI
T
P
D
V
V
T
L
A
K
GLGGG-L-
P
I
G
A
C
LAVG
P
A
A
E
L-LTPG-LHGSTFGG
N
P
V
C
A
A
A
A
L
A
V
L
R
V
L
AS----DG
L
V
R
R
A
E
V
L
G
K
S
L
R
H
G
I
--
E
A
-L
G
--
H
--
P
--
L
I
D
H
VRGR
G
L
L
L
G
I
A
L
--T---APH---AKD---AEAT-A---R-D---A
G
Y
L
VNAAAP-
D
V
I
RLAP
P
L
I
I
A
EAQ----L
D
G
F
V
A
A
L
P
A
I
L
D
R
AVGAP
111
HHSearch
93.45
43%
-111
- C1 -
4ADB
4
ASTC_ECOLI
A:
[14-402]
------------------
M
I
P
V
Y
A
P
--
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
T
F
A
D
----
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
-------
F
A
H
D
R
YGS--
H
---------
K
---------
S
---------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
S
Q
----
D
F
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
-----------------
I
N
S
A
S
A
L
I
-
D
-
D
-
S
----------
T
--
C
A
V
I
V
-
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
-
M
T
V
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
----
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
--
N
T
-
I
N
--
H
R
Y
G
--
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
--
N
---
A
D
Y
AGQ
A
K
Q
---
I
S
Q
E
-
A
---
A
-
K
---
A
G
V
M
V
L
I
A
G
G
-
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
----
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
--
6
PsiBlast_PDB
92.62
45%
-111
- C1 -
1VEF
2
ARGD_THET8
A:
[24-394]
----------------------
Y
N
K
--
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
---
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
-
P
P
E
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
------
T
---------
G
---------
R
---------
K
---------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
----
P
F
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
-----------------
V
E
A
L
K
R
A
V
-
D
-
E
-
E
----------
T
--
A
A
V
I
L
-
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
S
-
M
P
K
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
----
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
--
R
A
-
I
P
--
S
--
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
--
K
---
E
K
A
---
A
P
Y
---
I
A
R
L
-
E
---
K
-
E
---
H
R
V
L
A
L
Q
A
G
P
-
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
----
L
E
R
V
V
E
A
V
R
A
V
L
-------
116
HHSearch
92.61
45%
-111
- C1 -
1VEF
2
ARGD_THET8
A:
[25-395]
-----------------------
N
K
--
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
---
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
-
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
-------
H
---------
T
G--------
R
---------
K
---------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
----
P
F
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
-----------------
V
E
A
L
K
R
A
V
-
D
-
E
-
E
----------
T
--
A
A
V
I
L
-
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
S
-
M
P
K
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
----
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
--
R
A
-
I
P
--
S
--
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
--
K
---
E
K
----
A
A
P
---
Y
I
A
R
-
L
---
E
K
E
---
H
R
V
L
A
L
Q
A
G
P
-
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
----
L
E
R
V
V
E
A
V
R
A
V
L
A
------
8
PsiBlast_PDB
92.28
45%
-110
- C1 -
1WKH
2
ARGD_THET8
A:
[24-394]
----------------------
Y
N
K
--
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
---
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
-
P
P
E
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
------
T
---------
G
---------
R
---------
K
---------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
----
P
F
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
-----------------
V
E
A
L
K
R
A
V
-
D
-
E
-
E
----------
T
--
A
A
V
I
L
-
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
S
-
M
P
K
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
----
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
--
R
A
-
I
P
--
S
--
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
--
K
---
E
K
A
---
A
P
Y
---
I
A
R
L
-
E
---
K
-
E
---
H
R
V
L
A
L
Q
A
G
P
-
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
----
L
E
R
V
V
E
A
V
R
A
V
L
-------
7
PsiBlast_PDB
91.95
45%
-111
- C1 -
1WKG
2
ARGD_THET8
A:
[24-394]
----------------------
Y
N
K
--
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
---
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
-
P
P
E
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
------
T
---------
G
---------
R
---------
K
---------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
----
P
F
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
-----------------
V
E
A
L
K
R
A
V
-
D
-
E
-
E
----------
T
--
A
A
V
I
L
-
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
S
-
M
P
K
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
----
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
--
R
A
-
I
P
--
S
--
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
--
K
---
E
K
A
---
A
P
Y
---
I
A
R
L
-
E
---
K
-
E
---
H
R
V
L
A
L
Q
A
G
P
-
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
----
L
E
R
V
V
E
A
V
R
A
V
L
-------
32
PsiBlast_CBE
91.40
45%
-110
- C1 -
1VEF
2
ARGD_THET8
B:
[24-394]
----------------------
Y
N
K
--
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
---
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
-
P
P
E
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H------
T
---------
G
---------
R
---------
K
---------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
----
P
F
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
-----------------
V
E
A
L
K
R
A
V
-
D
-
E
-
E
----------
T
--
A
A
V
I
L
-
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
S
-
M
P
K
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
----
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
--
R
A
-
I
P
--
S
--
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
--
K
---
E
K
A
---
A
P
Y
---
I
A
R
L
-
E
---
K
-
E
---
H
R
V
L
A
L
Q
A
G
P
-
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
----
L
E
R
V
V
E
A
V
R
A
V
L
-------
117
HHSearch
90.61
41%
-114
- C1 -
2ORD
14
ARGD_THEMA
A:
[21-396]
------------------------
R
--
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
I
H
C
S
-
N
L
---
F
W
N
R
P
Q
M
E
L
A
E
L
L
S
K
N
T
F
G
G
----
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
-------
Y
-------------------
G
K
K
K
SEKK--
Y
---------
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
-
Y
Q
K
----
P
F
E
P
L
V
P
G
F
E
Y
F
E
F
N
N
-----------------
V
E
D
L
R
R
K
M
-
S
-
E
-
D
----------
V
--
C
A
V
F
L
-
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
-
P
I
G
A
V
I
V
N
E
R
A
N
-
V
-
L
E
P
G
-
D
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
----
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
--
Q
E
-
M
K
--
E
E
Y
D
--
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
--
R
---
E
E
V
S--
N
R
E
---
V
A
T
K
-
C
---
F
-
E
---
N
K
L
L
V
V
P
A
G
N
-
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
----
I
D
L
A
V
E
T
L
K
K
V
L
Q
G
-----
31
PsiBlast_CBE
90.39
45%
-107
- C1 -
1WKG
2
ARGD_THET8
B:
[24-394]
----------------------
Y
N
K
--
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
---
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
-
P
P
E
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H------
T
---------
G
---------
R
---------
K
---------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
----
P
F
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
-----------------
V
E
A
L
K
R
A
V
-
D
-
E
-
E
----------
T
--
A
A
V
I
L
-
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
S
-
M
P
K
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
----
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
--
R
A
-
I
P
--
S
--
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
--
K
---
E
K
A
---
A
P
Y
---
I
A
R
L
-
E
---
K
-
E
---
H
R
V
L
A
L
Q
A
G
P
-
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
----
L
E
R
V
V
E
A
V
R
A
V
L
-------
30
PsiBlast_CBE
90.33
45%
-108
- C1 -
1WKH
2
ARGD_THET8
B:
[24-394]
----------------------
Y
N
K
--
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
---
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
-
P
P
E
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H------
T
---------
G
---------
R
---------
K
---------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
----
P
F
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
-----------------
V
E
A
L
K
R
A
V
-
D
-
E
-
E
----------
T
--
A
A
V
I
L
-
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
A
V
M
R
E
E
V
A
R
S
-
M
P
K
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
----
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
--
R
A
-
I
P
--
S
--
P
--
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
--
K
---
E
K
A
---
A
P
Y
---
I
A
R
L
-
E
---
K
-
E
---
H
R
V
L
A
L
Q
A
G
P
-
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
----
L
E
R
V
V
E
A
V
R
A
V
L
-------
2
PsiBlast_PDB
88.23
42%
-108
- C1 -
4ADC
2
ASTC_ECOLI
A:
[7-402]
-----------
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
--
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
T
F
A
D
----
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
YG
S
---------
H
---------
K
---------
S
---------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
S
Q
----
D
F
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
-----------------
I
N
S
A
S
A
L
I
-
D
-
D
-
S
----------
T
--
C
A
V
I
V
-
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
-
M
T
V
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
--
H
R
-
Y
G
--------
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
--
N
---
A
D
Y
---
A
G
Q
---
A
K
Q
I
-
S
---
Q
-
E
A
A
K
A
G
V
M
V
L
I
A
G
G
-
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
103
HHSearch
87.78
40%
-110
- C1 -
4JF1
9
ARGD_SALTY
A:
[27-420]
-------------
T
F
D
E
V
I
L
P
V
Y
A
P
--
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
----
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
-------
Y
A
C
V
R
HSP--
F
---------
K
---------
T
---------
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
----
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
D
-----------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
----------
T
--
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
-------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
----
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
--
Q
A
-
I
D
--
E
Q
F
D
--
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--
K
---
P
K
Y
KGR
A
R
D
---
F
L
Y
A
-
G
---
A
-
E
---
A
G
V
M
V
L
N
A
G
A
-
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
----
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
--
23
PsiBlast_CBE
87.26
42%
-108
- C1 -
4ADD
4
ASTC_ECOLI
B:
[7-402]
-----------
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
--
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
T
F
A
D
----
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
FAHDRYG
S
---------
H
---------
K
---------
S
---------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
S
Q
----
D
F
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
-----------------
I
N
S
A
S
A
L
I
-
D
-
D
-
S
----------
T
--
C
A
V
I
V
-
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
-
M
T
V
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
PEML
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
--
H
R
-
Y
G
--------
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
--
N
---
A
D
Y
---
A
G
Q
---
A
K
Q
I
-
S
---
Q
-
E
AAK
A
G
V
M
V
L
I
A
G
G
-
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
VTTG
L
D
R
F
A
A
A
C
E
H
F
V
S
------
3
PsiBlast_PDB
87.13
42%
-107
- C1 -
4ADD
4
ASTC_ECOLI
A:
[7-402]
-----------
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
--
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
T
F
A
D
----
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
YG
S
---------
H
---------
K
---------
S
---------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
S
Q
----
D
F
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
-----------------
I
N
S
A
S
A
L
I
-
D
-
D
-
S
----------
T
--
C
A
V
I
V
-
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
-
M
T
V
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
--
H
R
-
Y
G
--------
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
--
N
---
A
D
Y
---
A
G
Q
---
A
K
Q
I
-
S
---
Q
-
E
A
A
K
A
G
V
M
V
L
I
A
G
G
-
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
21
PsiBlast_CBE
86.70
42%
-108
- C1 -
4ADD
4
ASTC_ECOLI
D:
[7-402]
-----------
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
--
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
T
F
A
D
----
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
FAHDRYG
S
---------
H
---------
K
---------
S
---------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
S
Q
----
D
F
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
-----------------
I
N
S
A
S
A
L
I
-
D
-
D
-
S
----------
T
--
C
A
V
I
V
-
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
-
M
T
V
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
PEML
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
--
H
R
-
Y
G
--------
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
--
N
---
A
D
Y
---
A
G
Q
---
A
K
Q
I
-
S
---
Q
-
E
AAK
A
G
V
M
V
L
I
A
G
G
-
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
VTTG
L
D
R
F
A
A
A
C
E
H
F
V
S
------
1
PsiBlast_PDB
86.65
42%
-108
- C1 -
4ADB
4
ASTC_ECOLI
A:
[7-402]
-----------
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
--
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
T
F
A
D
----
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
R
YG
S
---------
H
---------
K
---------
S
---------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
S
Q
----
D
F
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
-----------------
I
N
S
A
S
A
L
I
-
D
-
D
-
S
----------
T
--
C
A
V
I
V
-
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
-
M
T
V
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
--
H
R
-
Y
G
--------
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
--
N
---
A
D
Y
---
A
G
Q
---
A
K
Q
I
-
S
---
Q
-
E
A
A
K
A
G
V
M
V
L
I
A
G
G
-
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
24
PsiBlast_CBE
86.27
42%
-108
- C1 -
4ADC
2
ASTC_ECOLI
D:
[7-402]
-----------
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
--
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
T
F
A
D
----
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
FAHDRYG
S
---------
H
---------
K
---------
S
---------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
S
Q
----
D
F
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
-----------------
I
N
S
A
S
A
L
I
-
D
-
D
-
S
----------
T
--
C
A
V
I
V
-
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
-
M
T
V
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
PEML
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
--
H
R
-
Y
G
--------
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
--
N
---
A
D
Y
---
A
G
Q
---
A
K
Q
I
-
S
---
Q
-
E
AAK
A
G
V
M
V
L
I
A
G
G
-
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
VTTG
L
D
R
F
A
A
A
C
E
H
F
V
S
------
22
PsiBlast_CBE
86.25
42%
-106
- C1 -
4ADD
4
ASTC_ECOLI
C:
[7-402]
-----------
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
--
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
T
F
A
D
----
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
FAHDRYG
S
---------
H
---------
K
---------
S
---------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
S
Q
----
D
F
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
-----------------
I
N
S
A
S
A
L
I
-
D
-
D
-
S
----------
T
--
C
A
V
I
V
-
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
-
M
T
V
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
PEML
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
--
H
R
-
Y
G
--------
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
--
N
---
A
D
Y
---
A
G
Q
---
A
K
Q
I
-
S
---
Q
-
E
AAK
A
G
V
M
V
L
I
A
G
G
-
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
VTTG
L
D
R
F
A
A
A
C
E
H
F
V
S
------
27
PsiBlast_CBE
86.13
42%
-110
- C1 -
4ADB
3
ASTC_ECOLI
D:
[7-402]
-----------
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
--
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
T
F
A
D
----
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
FAHDRYG
S
---------
H
---------
K
---------
S
---------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
S
Q
----
D
F
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
-----------------
I
N
S
A
S
A
L
I
-
D
-
D
-
S
----------
T
--
C
A
V
I
V
-
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
-
M
T
V
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
PEML
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
--
H
R
-
Y
G
--------
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
--
N
---
A
D
Y
---
A
G
Q
---
A
K
Q
I
-
S
---
Q
-
E
AAK
A
G
V
M
V
L
I
A
G
G
-
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
VTTG
L
D
R
F
A
A
A
C
E
H
F
V
S
------
5
PsiBlast_PDB
86.09
41%
-110
- C1 -
2E54
5
ARGD_THEMA
A:
[3-383]
------------------
L
M
N
T
Y
S
R
--
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
I
H
C
S
-
N
L
---
F
W
N
R
P
Q
M
E
L
A
E
----
L
L
S
K
N
T
F
G
G
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
-------
Y
---------
G
---------
K
---------
K
K
SEKKY---
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
-
Y
Q
K
----
P
F
E
P
L
V
P
G
F
E
Y
F
E
F
N
N
-----------------
V
E
D
L
R
R
K
M
-
S
-
E
-
D
----------
V
--
C
A
V
F
L
-
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
-
P
I
G
A
V
I
-
V
N
E
R
A
N
V
-
L
E
P
G
-
D
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
----
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
--
Q
E
-
M
K
E
E
Y
--
D
--
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
--
R
---
E
E
V
---
S
N
R
---
E
V
A
T
K
C
---
F
-
E
---
N
K
L
L
V
V
P
A
G
N
-
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
----
I
D
L
A
V
E
T
L
K
K
V
L
Q
------
4
PsiBlast_PDB
85.92
42%
-107
- C1 -
4ADE
-
ASTC_ECOLI
A:
[7-402]
-----------
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
--
A
P
F
I
P
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
---
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
T
F
A
D
----
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
RYG
S
---------
H
---------
K
---------
S
---------
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
-
Y
S
Q
----
D
F
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
-----------------
I
N
S
A
S
A
L
I
-
D
-
D
-
S
----------
T
--
C
A
V
I
V
-
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
L
L
A
T
E
E
C
A
R
V
-
M
T
V
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
--
H
R
-
Y
G
--------
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
--
N
---
A
D
Y
---
A
G
Q
---
A
K
Q
I
-
S
---
Q
-
E
A
A
K
A
G
V
M
V
L
I
A
G
G
-
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
S
------
102
HHSearch
85.46
35%
-110
- C1 -
2OAT
2
OAT_HUMAN
A:
[39-438]
------
T
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
P
--
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
Y
TVKGIQKY
K
---------
A
---------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
Q
D
-
P
-
N
----------
V
--
A
A
F
M
V
-
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
DWD
A
W
K
---
V
C
L
R
-
L
---
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
R
E
S
I
E
I
I
N
K
T
I
L
S
-----
104
HHSearch
83.36
33%
-113
- C1 -
4NOG
3
?
A:
[19-422]
-------
E
E
D
F
F
A
C
D
R
Q
Y
V
C
Q
N
Y
A
P
--
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
---
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
Y
D
----
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
-------
W
A
Y
E
VKEIPP
D
---------
S
---------
A
---------
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
-
C
Y
N
----
N
F
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
-----------------
V
G
A
L
E
E
A
L
-
K
D
P
-
N
----------
V
--
A
A
F
F
V
-
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
-
L
K
P
G
-
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
--
R
R
E
L
Y
--
G
KV
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
--
D
---
S
D
A
ID-
P
N
D
---
V
V
M
K
-
L
---
K
-
E
---
N
G
I
L
S
K
P
T
R
G
-
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
----
H
R
D
A
T
T
R
I
I
K
S
F
L
A
V
E
E
--
121
Fugue
79.11
34%
-111
- C1 -
2OAT
2
OAT_HUMAN
A:
[36-439]
-
G
P
P
T
S
D
--
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
--HP
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
-
S
Q
V
D
K
L
--
T
-
L
T
SRA
F
Y
N
N
V
L
G
E
Y
E
E
-
Y
I
T
K
L
F
--
N
Y
H
-
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
TVKGIQKYK
A
---------
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S-
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
-----------NV
A
A
F
M
V
-
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
-G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
ETK
D
W
D
---
A
W
K
---
V
C
L
R
-
L
---
R
-
D
---
N
G
L
L
A
K
P
T
H
-G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
----
37
PsiBlast_CBE
78.27
39%
-102
- C1 -
4JF1
9
ARGD_SALTY
B:
[33-404]
-------------------
L
P
V
Y
A
P
--
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
----
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
-------
Y
---------
A
C
V
R
HSPF--
K
---------
T
---------
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
----
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
D
-----------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
----------
T
--
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
H
V
G
-
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
----
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
--
Q
A
-
I
D
--
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--
K
---
P
K
Y
KGR
A
R
D
---
F
L
Y
A
-
G
---
A
-
E
---
A
G
V
M
V
L
N
A
G
A
-
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
----
I
------------------
36
PsiBlast_CBE
78.03
40%
-102
- C1 -
4JEW
13
ARGD_SALTY
B:
[31-404]
-----------------
V
I
L
P
V
Y
A
P
--
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
----
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
-------
Y
---------
A
C
V
R
HSPF--
K
---------
T
---------
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
----
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
D
-----------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
----------
T
--
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
H
V
G
-
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
----
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
--
Q
A
-
I
D
--
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--
K
---
P
K
Y
KGR
A
R
D
---
F
L
Y
A
-
G
---
A
-
E
---
A
G
V
M
V
L
N
A
G
A
-
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
----
I
------------------
39
PsiBlast_CBE
77.65
39%
-102
- C1 -
4JEY
13
ARGD_SALTY
B:
[33-404]
-------------------
L
P
V
Y
A
P
--
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
----
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
-------
Y
---------
A
C
V
R
HSPF--
K
---------
T
---------
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
----
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
D
-----------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
----------
T
--
C
A
V
V
V
-
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
H
V
G
-
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
----
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
--
Q
A
-
I
D
--
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--
K
---
P
K
Y
KGR
A
R
D
---
F
L
Y
A
-
G
---
A
-
E
---
A
G
V
M
V
L
N
A
G
A
-
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
----
I
------------------
63
PsiBlast_CBE
76.79
36%
-109
- C1 -
2BYL
1
OAT_HUMAN
C:
[59-425]
----------------------------
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
---------
T
VKGIQKYKA
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
----------
N
--
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
---
D
W
D
---
A
W
K
V
-
C
LRL
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
------------------
59
PsiBlast_CBE
76.09
35%
-104
- C1 -
2OAT
2
OAT_HUMAN
A:
[39-425]
------
T
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
P
--
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
---------
T
VKGIQKYK
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
----------
N
--
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
---
D
W
D
---
A
W
K
V
-
C
L
R
L
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
------------------
38
PsiBlast_CBE
75.87
39%
-102
- C1 -
4JEZ
13
ARGD_SALTY
B:
[33-404]
-------------------
L
P
V
Y
A
P
--
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
R
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
----
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
-------
Y
---------
A
C
V
R
HSPF--
K
---------
T
---------
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
----
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
D
-----------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
----------
T
--
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
----
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
--
Q
A
-
I
D
--
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--
K
---
P
K
Y
KGR
A
R
D
---
F
L
Y
A
-
G
---
A
-
E
---
A
G
V
M
V
L
N
A
G
A
-
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
----
I
------------------
65
PsiBlast_CBE
75.58
36%
-108
- C1 -
2BYL
2
OAT_HUMAN
A:
[59-425]
----------------------------
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
---------
T
VKGIQKYK
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
----------
N
--
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
---
D
W
D
---
A
W
K
V
-
C
L
R
L
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
------------------
75
PsiBlast_CBE
75.24
34%
-106
- C1 -
4ZWM
12
?
A:
[42-420]
---------------
R
Q
Y
V
C
Q
N
Y
A
---
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
---
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
Y
D
----
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
-------
W
---------
A
---------
Y
---------
E
VKEIPPDS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
-
C
Y
N
----
N
F
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
-----------------
V
G
A
L
E
E
A
L
-
K
-
D
P
N
----------
V
--
A
A
F
F
V
-
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
-
L
K
P
G
-
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
-
Y
G
--
K
V-
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
DS
D
---
A
I
D
---
P
N
D
---
V
V
M
K
-
L
---
K
-
E
---
N
G
I
L
S
K
P
T
R
G
-
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
-----------------------
50
PsiBlast_CBE
74.64
35%
-103
- C1 -
2BYJ
2
OAT_HUMAN
A:
[39-425]
------
T
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
P
--
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
---------
T
VKGIQKYK
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
----------
N
--
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
---
D
W
D
---
A
W
K
V
-
C
L
R
L
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
------------------
78
PsiBlast_CBE
74.46
34%
-107
- C1 -
4NOG
6
?
B:
[27-405]
---------------
R
Q
Y
V
C
Q
N
Y
A
P
--
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
---
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
Y
D
----
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
-------
W
---------
A
---------
Y
---------
E
VKEIPPDS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
-
C
Y
N
----
N
F
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
-----------------
V
G
A
L
E
E
A
L
-
K
-
D
P
N
----------
V
--
A
A
F
F
V
-
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
-
L
K
P
G
-
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
-
Y
G
--
K
V-
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
DS
D
---
A
I
D
---
P
N
D
---
V
V
M
K
-
L
---
K
-
E
---
N
G
I
L
S
K
P
T
R
G
-
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
-----------------------
64
PsiBlast_CBE
73.90
36%
-107
- C1 -
2BYL
2
OAT_HUMAN
B:
[59-425]
----------------------------
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
---------
T
VKGIQKYKA
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
----------
N
--
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
---
D
W
D
---
A
W
K
V
-
C
LRL
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
------------------
76
PsiBlast_CBE
73.85
34%
-108
- C1 -
4ZLV
6
?
B:
[42-420]
---------------
R
Q
Y
V
C
Q
N
Y
A
P
--
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
---
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
Y
D
----
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
-------
W
---------
A
---------
Y
---------
E
VKEIPPDSA
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
-
C
Y
N
----
N
F
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
-----------------
V
G
A
L
E
E
A
L
-
K
-
D
P
N
----------
V
--
A
A
F
F
V
-
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
-
L
K
P
G
-
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
RR
E
L
-
Y
G
--
K
V-
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
DS
D
---
A
I
D
---
P
N
D
---
V
V
M
K
-
L
---
K
-
E
---
N
G
I
L
S
K
P
T
R
G
-
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
-----------------------
48
PsiBlast_CBE
73.84
35%
-103
- C1 -
2BYJ
1
OAT_HUMAN
C:
[39-425]
------
T
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
P
--
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
---------
T
VKGIQKYKA
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
----------
N
--
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
---
D
W
D
---
A
W
K
V
-
C
LRL
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
------------------
40
PsiBlast_CBE
73.79
39%
-102
- C1 -
4JEX
17
ARGD_SALTY
B:
[33-404]
-------------------
L
P
V
K
A
P
--
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
---
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
E
----
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
-------
Y
---------
A
C
V
R
HSPF--
K
---------
T
---------
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
----
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
D
-----------------
L
H
A
V
K
A
V
M
-
D
-
D
-
H
----------
T
--
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
----
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
--
Q
A
-
I
D
--
E
--
Q
FD
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
--
K
---
P
K
Y
KGR
A
R
D
---
F
L
Y
A
-
G
---
A
-
E
---
A
G
V
M
V
L
N
A
G
A
-
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
----
I
------------------
71
PsiBlast_CBE
73.70
34%
-106
- C1 -
5EQC
7
?
A:
[42-420]
---------------
R
Q
Y
V
C
Q
N
Y
A
P
--
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
---
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
Y
D
----
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
-------
W
---------
A
---------
Y
---------
E
VKEIPPDS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
-
C
Y
N
----
N
F
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
-----------------
V
G
A
L
E
E
A
L
-
K
-
D
P
N
----------
V
--
A
A
F
F
V
-
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
-
L
K
P
G
-
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
-
Y
G
--
K
V-
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
DS
D
---
A
I
D
---
P
N
D
---
V
V
M
K
-
L
---
K
-
E
---
N
G
I
L
S
K
P
T
R
G
-
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
-----------------------
57
PsiBlast_CBE
73.53
35%
-105
- C1 -
2OAT
1
OAT_HUMAN
C:
[39-425]
------
T
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
P
--
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
---------
T
VKGIQKYKA
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
----------
N
--
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
---
D
W
D
---
A
W
K
V
-
C
LRL
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
------------------
62
PsiBlast_CBE
73.44
35%
-105
- C1 -
1OAT
2
OAT_HUMAN
A:
[39-425]
------
T
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
P
--
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
---------
T
VKGIQKYK
A
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
----------
N
--
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
---
D
W
D
---
A
W
K
V
-
C
L
R
L
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
------------------
74
PsiBlast_CBE
73.37
34%
-107
- C1 -
4ZWM
10
?
B:
[42-420]
---------------
R
Q
Y
V
C
Q
N
Y
A
---
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
---
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
Y
D
----
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
-------
W
---------
A
---------
Y
---------
E
VKEIPPDS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
-
C
Y
N
----
N
F
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
-----------------
V
G
A
L
E
E
A
L
-
K
-
D
P
N
----------
V
--
A
A
F
F
V
-
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
-
L
K
P
G
-
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
-
Y
G
--
K
V-
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
DS
D
---
A
I
D
---
P
N
D
---
V
V
M
K
-
L
---
K
-
E
---
N
G
I
L
S
K
P
T
R
G
-
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
-----------------------
60
PsiBlast_CBE
73.37
35%
-105
- C1 -
1OAT
1
OAT_HUMAN
C:
[39-425]
------
T
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
P
--
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
---------
T
VKGIQKYKA
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
----------
N
--
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
---
D
W
D
---
A
W
K
V
-
C
LRL
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
------------------
49
PsiBlast_CBE
73.24
35%
-103
- C1 -
2BYJ
2
OAT_HUMAN
B:
[39-425]
------
T
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
P
--
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
---------
T
VKGIQKYKA
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
----------
N
--
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
---
D
W
D
---
A
W
K
V
-
C
LRL
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
------------------
79
PsiBlast_CBE
73.15
34%
-106
- C1 -
4NOG
3
?
A:
[27-405]
---------------
R
Q
Y
V
C
Q
N
Y
A
P
--
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
---
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
Y
D
----
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
-------
W
---------
A
---------
Y
---------
E
VKEIPPDS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
-
C
Y
N
----
N
F
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
-----------------
V
G
A
L
E
E
A
L
-
K
-
D
P
N
----------
V
--
A
A
F
F
V
-
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
-
L
K
P
G
-
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
-
Y
G
--
K
V-
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
DS
D
---
A
I
D
---
P
N
D
---
V
V
M
K
-
L
---
K
-
E
---
N
G
I
L
S
K
P
T
R
G
-
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
-----------------------
77
PsiBlast_CBE
72.75
34%
-106
- C1 -
4ZLV
5
?
A:
[42-420]
---------------
R
Q
Y
V
C
Q
N
Y
A
P
--
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
---
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
Y
D
----
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
-------
W
---------
A
---------
Y
---------
E
VKEIPPDS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
-
C
Y
N
----
N
F
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
-----------------
V
G
A
L
E
E
A
L
-
K
-
D
P
N
----------
V
--
A
A
F
F
V
-
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
-
L
K
P
G
-
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
-
Y
G
--
K
V-
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
DS
D
---
A
I
D
---
P
N
D
---
V
V
M
K
-
L
---
K
-
E
---
N
G
I
L
S
K
P
T
R
G
-
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
-----------------------
61
PsiBlast_CBE
72.74
35%
-104
- C1 -
1OAT
2
OAT_HUMAN
B:
[39-425]
------
T
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
P
--
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
---------
T
VKGIQKYKA
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
----------
N
--
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
---
D
W
D
---
A
W
K
V
-
C
LRL
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
------------------
58
PsiBlast_CBE
72.61
35%
-103
- C1 -
2OAT
2
OAT_HUMAN
B:
[39-425]
------
T
S
D
D
I
F
E
R
E
Y
K
Y
G
A
H
N
Y
H
P
--
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
---
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
F
N
Y
H
----
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
-------
W
---------
G
---------
Y
---------
T
VKGIQKYKA
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
-
S
Y
D
----
G
F
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
-----------------
L
P
A
L
E
R
A
L
-
Q
-
D
-
P
----------
N
--
V
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
-
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
-
I
K
P
G
-
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
----
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
--
M
K
-
L
P
--
S
--
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
--
K
---
E
T
K
---
D
W
D
---
A
W
K
V
-
C
LRL
R
-
D
---
N
G
L
L
A
K
P
T
H
G
-
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
----
L
------------------
70
PsiBlast_CBE
71.19
34%
-105
- C1 -
5EQC
8
?
B:
[42-420]
---------------
R
Q
Y
V
C
Q
N
Y
A
----
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
Q
A
E
R
L
T
L
T
L
-
R
A
---
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
F
G
Y
D
----
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
-------
W
---------
A
---------
Y
---------
E
VKEIPPDS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
-
C
Y
N
----
N
F
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
-----------------
V
G
A
L
E
E
A
L
-
K
-
D
P
N
----------
V
--
A
A
F
F
V
-
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
V
M
G
R
A
D
V
M
D
V
-
L
K
P
G
-
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
----
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
R
D
C
L
R
R
E
L
-
Y
G
--
K
V-
P
--
W
I
K
E
I
R
G
R
G
L
L
N
A
V
E
V
DS
D
---
A
I
D
---
P
N
D
---
V
V
M
K
-
L
---
K
-
E
---
N
G
I
L
S
K
P
T
R
G
-
R
V
M
R
F
I
P
P
L
V
I
T
D
E
E
-----------------------
80
PsiBlast_CBE
61.74
35%
-96
- C1 -
2EO5
3
?
A:
[25-403]
----------------------------
P
L
V
I
D
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
S
H
P
E
V
I
K
I
G
I
E
Q
M
Q
K
L
A
H
A
A
A
N
D
---
F
Y
N
I
P
Q
L
E
L
A
K
K
L
V
T
Y
S
P
G
N
F
Q
K
-
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
-------
T
---------
G
---------
R
---------
K
---------
Y
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
S
K
A
-
V
Q
R
SIVG
P
F
M
P
---
G
V
I
H
V
P
Y
P
N
PYRNPWHINGYEN
P
S
E
L
V
N
R
V
I
E
F
I
-
E
-
D
-
Y
IFVNLVPPEE
V
--
A
G
I
F
F
-
E
P
I
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
M
-
P
I
G
A
T
I
F
---
R
K
D
L
D
F
K
-------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
D
------
L
L
P
H
V
N
E
I
G
K
I
F
A
E
E
L
--
Q
G
-
L
A
----------
D
D
V
R
G
I
G
L
A
W
G
L
E
Y
--
N
---
E
K
K
---
V
R
D
R
I
I
G
E
S
F
-
K
---
R
------
G
L
L
L
L
P
A
G
R
-
S
A
I
R
V
I
P
P
L
V
I
S
E
E
E
-----------------------