@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1656: (2016-05-03 )
MIRHFLRDDDLSPAEQAEVLELAAELKKDPVSRRPLQGPRGVAVIFDKNSTRTRFSFELGIAQLGGHAVVVDSGSTQLGRDETLQDTAKVLSRYVDAIVWRTFGQERLDAMASVATVPVINALSDEFHPCQVLADLQTIAERKGALRGLRLSYFGDGANNMAHSLLLGGVTAGIHVTVAAPEGFLPDPSVRAAAERRAQDTGASVTVTADAHAAAAGADVLVTDTWTSMGQENDGLDRVKPFRPFQLNSRLLALADSDAIVLHCLPAHRGDEITDAVMDGPASAVWDEAENRLHAQKALLVWLLERS
Atome Classification :
(47 SA)
.........10........20..----....---..30--.-.---..---.....40........50........60........-70....------....80-----.-........90........100-....----------....110.......120...-....130.......140--.--..---.--...----.150....-...160.......-.170.......180-..-.....190.......200.......210.......220.......230..-..-.-.-..240...----.....250.-.-.....260.....------------------.------------------.270----------------........280.......290.......300.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
R
H
F
LRDDDL
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---KDP---V-S---RR---PLQGPR
G
V
A
V
I
F
DKNS
T
R
T
R
F
S
F
E
L
G
I
A
QLGG
H
A
V
-
V
VDSGS------TQLGR------
D
-
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
--
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
LSD-EF
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
---
R
--
K
G
---A--LRG----
L
R
L
S
Y
FGD-
G
A
N
N
-
M
A
H
S
L
L
L
G-GVTA
G
I
H
V
T
V
AAPE-GF-LPD
P
S
V
R
A
A
A
E
R
RAQDTG
A
S
V
T
V
T
ADAHAAAAG
A
D
V
L
V
TDTWTSMGQ-EN-DG-L-D-RVK-PFRP----FQLNS
R
L
L
A
-L-ADS
D
A
I
V
L
H
C
LPA------------------H------------------RGD-----------------
E
I
T
D
A
V
MDGP
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
ERS
1
PsiBlast_PDB
97.05
99%
-107
- C9 -
2I6U
5
OTC_MYCTU
A:
[1-307]
V
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
P
---
V
-
S
---
R
R
---
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
------
T
Q
L
G
R
------
D
-
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
--
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
-
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
---
R
--
K
G
---
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
-
G
A
N
N
-
M
A
H
S
L
L
L
G
-
G
V
T
A
G
I
H
V
T
V
A
A
P
E
-
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
-
D
G
-
L
-
D
-
R
V
K
-
P
F
R
P
----
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
------------------
R
G
D
-----------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
25
PsiBlast_CBE
96.37
99%
-104
- C9 -
2I6U
5
OTC_MYCTU
C:
[1-307]
V
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
P
---
V
-
S
---
R
R
---
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
------
T
Q
L
G
R
------
D
-
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
--
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
-
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
---
R
--
K
G
---
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
-
G
A
N
N
-
M
A
H
S
L
L
L
G
-
G
V
T
A
G
I
H
V
T
V
A
A
P
E
-
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
-
D
G
-
L
-
D
-
R
V
K
-
P
F
R
P
----
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
------------------
R
G
D
-----------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
21
PsiBlast_CBE
96.22
99%
-117
- C9 -
2P2G
3
OTC_MYCTU
F:
[1-307]
V
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
P
---
V
-
S
---
R
R
---
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
------
T
Q
L
G
R
------
D
-
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
--
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
-
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
---
R
--
K
G
---
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
-
G
A
N
N
-
M
A
H
S
L
L
L
G
-
G
V
T
A
G
I
H
V
T
V
A
A
P
E
-
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
-----------------
V
K
-
P
F
R
P
----
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
------------------
R
G
D
-----------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
26
PsiBlast_CBE
96.01
99%
-104
- C9 -
2I6U
5
OTC_MYCTU
B:
[1-307]
V
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
P
---
V
-
S
---
R
R
---
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
------
T
Q
L
G
R
------
D
-
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
--
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
-
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
---
R
--
K
G
---
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
-
G
A
N
N
-
M
A
H
S
L
L
L
G
-
G
V
T
A
G
I
H
V
T
V
A
A
P
E
-
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
-
D
G
-
L
-
D
-
R
V
K
-
P
F
R
P
----
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
------------------
R
G
D
-----------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
22
PsiBlast_CBE
95.98
99%
-114
- C9 -
2P2G
3
OTC_MYCTU
D:
[1-307]
V
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
P
---
V
-
S
---
R
R
---
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
------
T
Q
L
G
R
------
D
-
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
--
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
-
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
---
R
--
K
G
---
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
-
G
A
N
N
-
M
A
H
S
L
L
L
G
-
G
V
T
A
G
I
H
V
T
V
A
A
P
E
-
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
-----------------
V
K
-
P
F
R
P
----
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
------------------
R
G
D
-----------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
24
PsiBlast_CBE
95.57
99%
-114
- C9 -
2P2G
5
OTC_MYCTU
B:
[1-307]
V
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
P
---
V
-
S
---
R
R
---
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
------
T
Q
L
G
R
------
D
-
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
--
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
-
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
---
R
--
K
G
---
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
-
G
A
N
N
-
M
A
H
S
L
L
L
G
-
G
V
T
A
G
I
H
V
T
V
A
A
P
E
-
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
-----------------
V
K
-
P
F
R
P
----
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
------------------
R
G
D
-----------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
111
HHSearch
94.78
98%
-104
- C9 -
2I6U
5
OTC_MYCTU
A:
[2-307]
-
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
P
---
V
S
R
---
R
P
---
L
Q
G
P
-
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
------
T
Q
L
G
R
------
D
-
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
--
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
-
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
---
R
--
K
G
---
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
-
G
A
N
N
-
M
A
H
S
L
L
L
G
-
G
V
T
A
G
I
H
V
T
V
A
A
P
E
-
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
N
-
D
G
-
L
-
D
-
R
V
K
-
P
F
R
P
----
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
------------------
R
G
D
-----------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
2
PsiBlast_PDB
94.55
99%
-113
- C9 -
2P2G
5
OTC_MYCTU
A:
[1-307]
V
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
P
---
V
-
S
---
R
R
---
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
------
T
Q
L
G
R
------
D
-
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
--
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
-
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
---
R
--
K
G
---
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
-
G
A
N
N
-
M
A
H
S
L
L
L
G
-
G
V
T
A
G
I
H
V
T
V
A
A
P
E
-
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
-----------------
V
K
-
P
F
R
P
----
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
------------------
R
G
D
-----------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
23
PsiBlast_CBE
94.28
99%
-111
- C9 -
2P2G
5
OTC_MYCTU
C:
[1-307]
V
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
----
A
E
L
K
---
K
D
P
---
V
-
S
---
R
R
---
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
-
V
V
D
S
G
S
------
T
Q
L
G
R
------
D
-
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
--
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
-
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
---
R
--
K
G
---
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
-
G
A
N
N
-
M
A
H
S
L
L
L
G
-
G
V
T
A
G
I
H
V
T
V
A
A
P
E
-
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
--------------
R
V
K
-
P
F
R
P
----
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
------------------
R
G
D
-----------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
120
HHSearch
79.82
48%
-101
- C9 -
4OH7
3
?
A:
[14-315]
G
I
K
H
F
I
D
L
S
T
V
P
A
T
E
L
R
A
I
L
E
D
A
----
K
A
R
K
---
A
R
L
K
A
-
G
E
V
---
E
R
---
P
Y
A
G
-
K
V
L
A
M
I
F
E
K
L
S
T
R
T
R
V
S
F
D
V
G
M
R
Q
L
G
G
E
T
I
-
M
L
T
G
S
E
------
M
Q
L
G
R
------
S
-
E
T
I
A
D
T
A
K
V
L
S
R
Y
V
D
A
I
M
I
R
--
T
T
A
H
----------
E
R
M
L
E
L
A
E
Y
A
T
V
P
V
I
N
A
L
T
D
-
D
T
H
P
C
Q
I
M
A
D
V
L
T
Y
E
E
---
H
--
R
G
---
P
--
I
K
G
----
K
T
F
A
W
M
G
D
-
G
N
-
N
-
V
L
H
S
L
V
E
A
-
A
A
R
F
D
F
N
V
N
I
A
T
P
K
-
G
S
-
E
P
K
S
Q
Y
I
D
W
A
R
A
N
----
G
A
G
I
M
S
T
T
D
P
E
K
A
A
S
G
A
D
C
I
V
T
D
T
W
V
S
M
G
Q
-
E
D
-
H
A
-
R
---
G
H
N
-
V
F
I
P
----
Y
Q
V
N
A
N
L
M
A
-
K
-
A
D
P
K
A
L
F
M
H
C
L
P
A
------------------
H
------------------
R
G
E
-----------------
E
V
T
D
E
V
I
D
G
P
Q
S
V
V
F
D
E
A
E
N
R
L
H
A
Q
K
A
I
L
A
W
C
L
Q
D
-
116
HHSearch
79.73
49%
-99
- C9 -
1PVV
2
OTC_PYRFU
A:
[6-312]
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
----
K
M
F
K
---
I
W
Q
K
I
-
G
K
P
---
H
R
---
L
L
E
G
-
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
-
Y
L
N
A
Q
D
------
L
Q
L
R
R
------
G
-
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
--
V
Y
D
H
----------
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
-
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
---
K
--
K
G
---
T
--
I
K
G
----
V
K
V
V
Y
V
G
D
-
G
N
-
N
-
V
A
H
S
L
M
I
A
-
G
T
K
L
G
A
D
V
V
V
A
T
P
E
-
G
Y
-
E
P
D
E
K
V
I
K
W
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
A
-
E
A
-
E
-
E
-
R
R
K
-
I
F
R
P
----
F
Q
V
N
K
D
L
V
K
-
H
-
A
K
P
D
Y
M
F
M
H
C
L
P
A
------------------
H
------------------
R
G
E
-----------------
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
G
G
-
117
HHSearch
79.56
44%
-100
- C9 -
4NF2
5
OTC_BACAN
A:
[34-335]
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
---
K
N
K
-----
Q
---
E
P
---
L
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
-
F
L
N
G
K
E
------
M
Q
M
Q
R
------
G
-
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
--
T
F
S
H
----------
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
-
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
---
E
--
T
N
---
T
--
F
K
G
----
I
K
L
A
Y
V
G
D
-
G
N
-
N
-
V
C
H
S
L
L
L
A
-
S
A
K
V
G
M
H
M
T
V
A
T
P
V
-
G
Y
-
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
G
-
E
E
-
E
---
K
Y
T
-
L
F
Q
P
----
Y
Q
I
N
K
E
L
V
K
-
H
-
A
K
Q
T
Y
H
F
L
H
C
L
P
A
------------------
H
------------------
R
E
E
-----------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
-
8
PsiBlast_PDB
79.11
48%
-100
- C9 -
4OH7
3
?
A:
[15-314]
-
I
K
H
F
I
D
L
S
T
V
P
A
T
E
L
R
A
I
L
E
D
A
K
A
R
K
A
R
L
K
---
A
G
E
---
V
-
E
---
R
----
P
Y
A
G
-
K
V
L
A
M
I
F
E
K
L
S
T
R
T
R
V
S
F
D
V
G
M
R
Q
L
G
G
E
T
I
-
M
L
T
G
S
E
------
M
Q
L
G
R
------
S
-
E
T
I
A
D
T
A
K
V
L
S
R
Y
V
D
A
I
M
I
R
--
T
T
A
H
----------
E
R
M
L
E
L
A
E
Y
A
T
V
P
V
I
N
A
L
T
D
-
D
T
H
P
C
Q
I
M
A
D
V
L
T
Y
E
E
---
H
--
R
G
---
P
--
I
K
G
----
K
T
F
A
W
M
G
D
-
G
-
N
N
-
V
L
H
S
L
V
E
A
-
A
A
R
F
D
F
N
V
N
I
A
T
P
K
-
G
S
-
E
P
----
K
S
Q
Y
I
D
W
A
R
A
N
G
A
G
I
M
S
T
T
D
P
E
K
A
A
S
G
A
D
C
I
V
T
D
T
W
V
S
M
G
Q
-
E
D
-
H
A
-
R
-
G
-
H
-
N
-
V
F
I
P
----
Y
Q
V
N
A
N
L
M
A
-
K
-
A
D
P
K
A
L
F
M
H
C
L
P
A
------------------
H
------------------
R
G
E
-----------------
E
V
T
D
E
V
I
D
G
P
Q
S
V
V
F
D
E
A
E
N
R
L
H
A
Q
K
A
I
L
A
W
C
L
Q
--
4
PsiBlast_PDB
79.06
50%
-95
- C9 -
1A1S
-
OTC_PYRFU
A:
[7-305]
--
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
----
K
M
F
K
I
W
Q
K
I
G
---
K
-
P
---
H
R
---
L
L
E
G
-
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
-
Y
L
N
A
Q
D
------
L
Q
L
R
R
------
G
-
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
--
V
Y
D
H
----------
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
-
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
---
K
--
K
G
---
T
--
I
K
G
----
V
K
V
V
Y
V
G
D
-
G
-
N
N
-
V
A
H
S
L
M
I
A
-
G
T
K
L
G
A
D
V
V
V
A
T
P
E
-
G
Y
-
E
P
D
E
K
V
I
K
W
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
A
-
E
A
-
E
-
E
-
R
R
K
-
I
F
R
P
----
F
Q
V
N
K
D
L
V
K
-
H
-
A
K
P
D
Y
M
F
M
H
C
L
P
A
------------------
H
------------------
R
G
E
-----------------
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
-------
112
HHSearch
78.99
52%
-111
- C9 -
3GD5
-
OTC_GLOVI
A:
[12-313]
F
R
P
D
L
L
S
L
D
D
L
D
E
A
Q
L
H
A
L
L
T
L
A
----
H
Q
L
K
---
R
G
E
-----
R
---
V
A
---
N
L
H
G
-
K
V
L
G
L
V
F
L
K
A
S
T
R
T
R
V
S
F
T
V
A
M
Y
Q
L
G
G
Q
V
I
-
D
L
-----------------------
E
P
V
R
D
T
A
R
V
L
G
R
Y
V
D
G
L
A
I
R
--
T
F
A
Q
----------
T
E
L
E
E
Y
A
H
Y
A
G
I
P
V
I
N
A
L
T
D
-
H
E
H
P
C
Q
V
V
A
D
L
L
T
I
R
E
---
N
--
F
G
---
R
--
L
A
G
----
L
K
L
A
Y
V
G
D
-
G
N
-
N
-
V
A
H
S
L
L
L
G
-
C
A
K
V
G
M
S
I
A
V
A
T
P
E
-
G
F
-
T
P
D
P
A
V
S
A
R
A
S
E
I
A
G
R
T
G
A
E
V
Q
I
L
R
D
P
F
E
A
A
R
G
A
H
I
L
Y
T
D
V
W
T
-------------
H
-
R
L
Q
-
L
F
E
Q
----
Y
Q
I
N
A
A
L
L
N
-
C
-
A
A
A
E
A
I
V
L
H
C
L
P
A
------------------
H
------------------
R
G
E
-----------------
E
I
T
D
E
V
M
E
G
P
R
S
R
I
W
D
E
A
E
N
R
L
H
A
Q
K
A
V
L
A
A
L
M
G
--
3
PsiBlast_PDB
78.59
50%
-96
- C9 -
1PVV
2
OTC_PYRFU
A:
[8-306]
--
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
----
K
M
F
K
I
W
Q
K
I
G
---
K
-
P
---
H
R
---
L
L
E
G
-
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
-
Y
L
N
A
Q
D
------
L
Q
L
R
R
------
G
-
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
--
V
Y
D
H
----------
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
-
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
---
K
--
K
G
---
T
--
I
K
G
----
V
K
V
V
Y
V
G
D
-
G
-
N
N
-
V
A
H
S
L
M
I
A
-
G
T
K
L
G
A
D
V
V
V
A
T
P
E
-
G
Y
-
E
P
D
E
K
V
I
K
W
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
A
-
E
A
-
E
-
E
-
R
R
K
-
I
F
R
P
----
F
Q
V
N
K
D
L
V
K
-
H
-
A
K
P
D
Y
M
F
M
H
C
L
P
A
------------------
H
------------------
R
G
E
-----------------
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
-------
7
PsiBlast_PDB
78.31
44%
-96
- C9 -
4NF2
5
OTC_BACAN
A:
[36-335]
--
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
---
K
N
------
K
---
Q
E
---
P
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
-
F
L
N
G
K
E
------
M
Q
M
Q
R
------
G
-
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
--
T
F
S
H
----------
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
-
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
---
E
--
T
N
---
T
--
F
K
G
----
I
K
L
A
Y
V
G
D
-
G
-
N
N
-
V
C
H
S
L
L
L
A
-
S
A
K
V
G
M
H
M
T
V
A
T
P
V
-
G
Y
-
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
G
-
E
E
---
E
-
K
Y
T
-
L
F
Q
P
----
Y
Q
I
N
K
E
L
V
K
-
H
-
A
K
Q
T
Y
H
F
L
H
C
L
P
A
------------------
H
------------------
R
E
E
-----------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
-
27
PsiBlast_CBE
78.15
44%
-97
- C9 -
4NF2
4
OTC_BACAN
C:
[36-335]
--
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
---
K
N
------
K
---
Q
E
---
P
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
-
F
L
N
G
K
E
------
M
Q
M
Q
R
------
G
-
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
--
T
F
S
H
----------
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
-
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
---
E
--
T
N
---
T
--
F
K
G
----
I
K
L
A
Y
V
G
D
-
G
-
N
N
-
V
C
H
S
L
L
L
A
-
S
A
K
V
G
M
H
M
T
V
A
T
P
V
-
G
Y
-
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
G
-
E
E
---
E
-
K
Y
T
-
L
F
Q
P
----
Y
Q
I
N
K
E
L
V
K
-
H
-
A
K
Q
T
Y
H
F
L
H
C
L
P
A
------------------
H
------------------
R
E
E
-----------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
-
28
PsiBlast_CBE
77.97
44%
-98
- C9 -
4NF2
5
OTC_BACAN
B:
[36-335]
--
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
---
K
N
------
K
---
Q
E
---
P
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
-
F
L
N
G
K
E
------
M
Q
M
Q
R
------
G
-
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
--
T
F
S
H
----------
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
-
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
---
E
--
T
N
---
T
--
F
K
G
----
I
K
L
A
Y
V
G
D
-
G
-
N
N
-
V
C
H
S
L
L
L
A
-
S
A
K
V
G
M
H
M
T
V
A
T
P
V
-
G
Y
-
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
G
-
E
E
---
E
-
K
Y
T
-
L
F
Q
P
----
Y
Q
I
N
K
E
L
V
K
-
H
-
A
K
Q
T
Y
H
F
L
H
C
L
P
A
------------------
H
------------------
R
E
E
-----------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
-
6
PsiBlast_PDB
77.84
44%
-104
- C9 -
4EP1
-
OTC_BACAN
A:
[12-311]
--
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
----
I
Y
L
K
---
K
N
------
K
---
Q
E
---
P
L
L
Q
G
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
-
F
L
N
G
K
E
-------------------
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
--
T
F
S
H
----------
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
-
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
---
E
--
T
N
---
T
--
F
K
G
----
I
K
L
A
Y
V
G
D
-
G
-
N
N
-
V
C
H
S
L
L
L
A
-
S
A
K
V
G
M
H
M
T
V
A
T
P
V
-
G
Y
-
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
-------
G
-
E
E
---
E
-
K
Y
T
-
L
F
Q
P
----
Y
Q
I
N
K
E
L
V
K
-
H
-
A
K
Q
T
Y
H
F
L
H
C
L
P
A
------------------
H
------------------
R
E
E
-----------------
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
-
119
HHSearch
77.61
41%
-96
- C9 -
1OTH
1
OTC_HUMAN
A:
[5-311]
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
---
F
R
I
KQK
G
E
Y
---
L
P
---
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
-
F
L
T
T
Q
D
------
I
H
L
G
V
------
N
-
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
--
V
Y
K
Q
----------
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
-
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
---
H
--
Y
S
---
S
--
L
K
G
----
L
T
L
S
W
I
G
D
-
G
N
-
N
-
I
L
H
S
I
M
M
S
-
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
-
G
Y
-
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
-
E
K
-
K
-
K
-
R
L
Q
-
A
F
Q
G
----
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
R
------------------
K
------------------
P
-
E
-----------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
-
14
PsiBlast_PDB
77.42
40%
-97
- C9 -
1EP9
1
OTC_HUMAN
A:
[7-309]
--
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
F
R
I
K
Q
K
---
G
-
E
---
Y
L
---
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
-
F
L
T
T
Q
D
------
I
H
L
G
V
------
N
-
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
--
V
Y
K
Q
----------
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
-
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
---
H
--
Y
S
---
S
--
L
K
G
----
L
T
L
S
W
I
G
D
-
G
-
N
N
-
I
L
H
S
I
M
M
S
-
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
-
G
Y
-
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
-
E
K
-
K
-
K
-
R
L
Q
-
A
F
Q
G
----
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
-------------------
R
------------------
K
P
E
-----------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
---
15
PsiBlast_PDB
77.09
40%
-95
- C9 -
1FVO
1
OTC_HUMAN
A:
[7-309]
--
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
F
R
I
K
Q
K
---
G
-
E
---
Y
L
---
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
-
F
L
T
T
Q
D
------
I
H
L
G
V
------
N
-
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
--
V
Y
K
Q
----------
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
-
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
---
H
--
Y
S
---
S
--
L
K
G
----
L
T
L
S
W
I
G
D
-
G
-
N
N
-
I
L
H
S
I
M
M
S
-
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
-
G
Y
-
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
-
E
K
-
K
-
K
-
R
L
Q
-
A
F
Q
G
----
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
-------------------
R
------------------
K
P
E
-----------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
---
30
PsiBlast_CBE
77.08
40%
-96
- C9 -
1FVO
1
OTC_HUMAN
B:
[7-309]
--
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
FRI
K
Q
K
---
G
-
E
---
Y
L
---
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
-
F
L
T
T
Q
D
------
I
H
L
G
V
------
N
-
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
--
V
Y
K
Q
----------
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
-
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
---
H
--
Y
S
---
S
--
L
K
G
----
L
T
L
S
W
I
G
D
-
G
-
N
N
-
I
L
H
S
I
M
M
S
-
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
-
G
Y
-
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
-
E
K
-
K
-
K
-
R
L
Q
-
A
F
Q
G
----
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
-------------------
R
------------------
K
P
E
-----------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
---
13
PsiBlast_PDB
77.08
40%
-95
- C9 -
1C9Y
2
OTC_HUMAN
A:
[7-309]
--
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
F
R
I
K
Q
K
---
G
-
E
---
Y
L
---
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
-
F
L
T
T
Q
D
------
I
H
L
G
V
------
N
-
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
--
V
Y
K
Q
----------
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
-
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
---
H
--
Y
S
---
S
--
L
K
G
----
L
T
L
S
W
I
G
D
-
G
-
N
N
-
I
L
H
S
I
M
M
S
-
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
-
G
Y
-
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
-
E
K
-
K
-
K
-
R
L
Q
-
A
F
Q
G
----
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
-------------------
R
------------------
K
P
E
-----------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
---
12
PsiBlast_PDB
76.81
40%
-94
- C9 -
1OTH
1
OTC_HUMAN
A:
[7-309]
--
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
----
A
D
L
K
F
R
I
K
Q
K
---
G
-
E
---
Y
L
---
P
L
L
Q
G
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
-
F
L
T
T
Q
D
------
I
H
L
G
V
------
N
-
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
--
V
Y
K
Q
----------
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
-
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
---
H
--
Y
S
---
S
--
L
K
G
----
L
T
L
S
W
I
G
D
-
G
-
N
N
-
I
L
H
S
I
M
M
S
-
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
-
G
Y
-
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
E
-
E
K
-
K
-
K
-
R
L
Q
-
A
F
Q
G
----
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
-------------------
R
------------------
K
P
E
-----------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
---
121
HHSearch
76.21
36%
-106
- C9 -
4A8T
3
PTC_ENTFA
A:
[23-333]
M
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
---
E
A
I
K
N
-
G
Y
Y
---
P
Q
---
L
L
K
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
-
Y
L
A
P
G
-------
I
Q
L
G
G
------
H
-
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
--
V
E
R
H
----------
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
-
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
---
H
--
L
P
EGK
K
--
L
E
D
----
C
K
V
V
F
V
G
D
-
A
T
-
Q
-
V
C
F
S
L
G
L
I
-
T
T
K
M
G
M
N
F
V
H
F
G
P
E
-
G
F
-
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
-
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
-
A
E
L
S
E
-
E
-
E
-
R
M
K
V
F
Y
P
K
----
Y
Q
V
N
Q
E
M
M
D
-
R
-
A
G
A
N
C
K
F
M
H
C
L
P
A
------------------
T
------------------
R
G
E
-----------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
-
68
PsiBlast_CBE
75.95
36%
-104
- C9 -
4A8H
6
PTC_ENTFA
A:
[1-309]
M
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
E
A
I
K
N
G
---
Y
-
Y
---
P
Q
---
L
L
K
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
-
Y
L
A
P
G
Q
------
I
Q
L
G
G
------
H
-
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
--
V
E
R
H
----------
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
-
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
LP
E
--
G
K
---
K
--
L
E
D
----
C
K
V
V
F
V
G
D
--
A
T
Q
-
V
C
F
S
L
G
L
I
-
T
T
K
M
G
M
N
F
V
H
F
G
P
E
-
G
F
-
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
-
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
-
S
E
-
E
-
E
-
R
M
K
-
V
F
Y
P
K---
Y
Q
V
N
Q
E
M
M
D
-
R
-
A
G
A
N
C
K
F
M
H
C
L
P
A
------------------
T
------------------
R
G
E
-----------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
---
50
PsiBlast_CBE
75.89
35%
-101
- C9 -
4JFR
3
OTC_VIBVU
B:
[32-353]
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
A
K
---
Y
-
A
GTE
Q
K
---
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
------
S
Q
I
G
D
------
K
-
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
-
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S-
Q
--
G
K
---
A
--
L
A
D
----
I
Q
F
A
Y
L
G
D
-
A
R
N
N
-
V
G
N
S
L
M
V
G
-
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
-
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
-
E
A
-
W
-
D
E
R
V
A
-
L
M
K
P
----
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
------------------
H
N
D
ET
T
I
G
K
Q
V
A
D
K
F
GMKGL
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
------
48
PsiBlast_CBE
75.87
35%
-103
- C9 -
4JHX
3
OTC_VIBVU
A:
[32-353]
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
A
K
---
Y
-
A
GTE
Q
K
---
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
------
S
Q
I
G
D
------
K
-
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
-
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
-
Q
--
G
K
---
A
--
L
A
D
----
I
Q
F
A
Y
L
G
D
-
A
R
N
N
-
V
G
N
S
L
M
V
G
-
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
-
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
-
E
A
-
W
-
D
E
R
V
A
-
L
M
K
P
----
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
------------------
H
N
D
ET
T
I
G
K
Q
V
A
D
K
F
GMKGL
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
------
60
PsiBlast_CBE
75.49
36%
-109
- C9 -
4A8T
3
PTC_ENTFA
A:
[23-331]
M
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
E
A
I
K
N
G
---
Y
-
Y
---
P
Q
---
L
L
K
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
-
Y
L
A
P
G
-------
I
Q
L
G
G
------
H
-
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
--
V
E
R
H
----------
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
-
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
LP
E
--
G
K
---
K
--
L
E
D
----
C
K
V
V
F
V
G
D
--
A
T
Q
-
V
C
F
S
L
G
L
I
-
T
T
K
M
G
M
N
F
V
H
F
G
P
E
-
G
F
-
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
-
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
-
S
E
-
E
-
E
-
R
M
K
-
V
F
Y
P
K---
Y
Q
V
N
Q
E
M
M
D
-
R
-
A
G
A
N
C
K
F
M
H
C
L
P
A
------------------
T
------------------
R
G
E
-----------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
---
67
PsiBlast_CBE
75.34
36%
-107
- C9 -
4A8H
6
PTC_ENTFA
B:
[1-309]
M
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
----
L
K
I
K
EAI
K
N
G
---
Y
-
Y
---
P
Q
---
L
L
K
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
-
Y
L
A
P
G
Q
------
I
Q
L
G
G
------
H
-
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
--
V
E
R
H
----------
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
-
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
HLP
E
--
G
K
---
K
--
L
E
D
----
C
K
V
V
F
V
G
D
--
A
T
Q
-
V
C
F
S
L
G
L
I
-
T
T
K
M
G
M
N
F
V
H
F
G
P
E
-
G
F
-
Q
L
N
E
E
H
Q
A
K
L
A
K
N
C
E
V
S
G
G
S
F
L
V
T
D
D
A
-
S
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
L
-
S
E
-
E
-
E
-
R
M
K
-
V
F
Y
P
K---
Y
Q
V
N
Q
E
M
M
D
-
R
-
A
G
A
N
C
K
F
M
H
C
L
P
A
------------------
T
------------------
R
G
E
-----------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
---
51
PsiBlast_CBE
75.09
35%
-101
- C9 -
4JFR
2
OTC_VIBVU
A:
[32-353]
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
A
K
---
Y
-
A
GTE
Q
K
---
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
------
S
Q
I
G
D
------
K
-
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
-
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
-
Q
--
G
K
---
A
--
L
A
D
----
I
Q
F
A
Y
L
G
D
-
A
R
N
N
-
V
G
N
S
L
M
V
G
-
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
-
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
-
E
A
-
W
-
D
E
R
V
A
-
L
M
K
P
----
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
------------------
H
N
D
ET
T
I
G
K
Q
V
A
D
K
F
GMKGL
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
------
43
PsiBlast_CBE
74.80
35%
-100
- C9 -
4JQO
6
OTC_VIBVU
C:
[32-353]
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
A
K
---
Y
-
A
GTE
Q
K
---
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
------
S
Q
I
G
D
------
K
-
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
-
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
-
Q
--
G
K
---
A
--
L
A
D
----
I
Q
F
A
Y
L
G
D
-
A
R
N
N
-
V
G
N
S
L
M
V
G
-
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
-
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
-
E
A
-
W
-
D
E
R
V
A
-
L
M
K
P
----
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
------------------
H
N
D
ET
T
I
G
K
Q
V
A
D
K
F
GMKGL
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
------
123
HHSearch
74.73
38%
-100
- C9 -
4H31
14
OTC_VIBVU
A:
[30-357]
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
A
K
Y
A
-
G
T
E
---
Q
K
---
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
------
S
Q
I
G
D
------
K
-
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
-
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
---
H
--
S
Q
GK-
A
--
L
A
D
----
I
Q
F
A
Y
L
G
D
-
A
R
N
N
-
V
G
N
S
L
M
V
G
-
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
-
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
-
E
-
R
V
A
-
L
M
K
P
----
Y
Q
V
N
M
N
V
L
K
-
Q
T
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM-
K
G
L
-----------------
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
--
45
PsiBlast_CBE
74.66
35%
-100
- C9 -
4JQO
8
OTC_VIBVU
A:
[32-353]
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
A
K
---
Y
-
A
GTE
Q
K
---
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
------
S
Q
I
G
D
------
K
-
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
-
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S-
Q
--
G
K
---
A
--
L
A
D
----
I
Q
F
A
Y
L
G
D
-
A
R
N
N
-
V
G
N
S
L
M
V
G
-
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
-
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
-
E
A
-
W
-
D
E
R
V
A
-
L
M
K
P
----
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
------------------
H
N
D
ET
T
I
G
K
Q
V
A
D
K
F
GMKGL
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
------
54
PsiBlast_CBE
74.64
35%
-101
- C9 -
4H31
14
OTC_VIBVU
A:
[32-353]
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
A
K
---
Y
-
A
GTE
Q
K
---
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
------
S
Q
I
G
D
------
K
-
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
-
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
-
Q
--
G
K
---
A
--
L
A
D
----
I
Q
F
A
Y
L
G
D
-
A
R
N
N
-
V
G
N
S
L
M
V
G
-
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
-
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
-
E
A
-
W
-
D
E
R
V
A
-
L
M
K
P
----
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
------------------
H
N
D
ET
T
I
G
K
Q
V
A
D
K
F
GMKGL
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
------
53
PsiBlast_CBE
74.39
35%
-98
- C9 -
4H31
12
OTC_VIBVU
B:
[32-353]
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
A
K
---
Y
-
A
GTE
Q
K
---
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
------
S
Q
I
G
D
------
K
-
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
-
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S-
Q
--
G
K
---
A
--
L
A
D
----
I
Q
F
A
Y
L
G
D
-
A
R
N
N
-
V
G
N
S
L
M
V
G
-
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
-
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
-
E
A
-
W
-
D
E
R
V
A
-
L
M
K
P
----
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
------------------
H
N
D
ET
T
I
G
K
Q
V
A
D
K
F
GMKGL
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
------
44
PsiBlast_CBE
74.20
35%
-100
- C9 -
4JQO
6
OTC_VIBVU
B:
[32-353]
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
----
A
D
L
K
---
K
A
K
---
Y
-
A
GTE
Q
K
---
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
-
Y
I
G
P
S
G
------
S
Q
I
G
D
------
K
-
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
-
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S-
Q
--
G
K
---
A
--
L
A
D
----
I
Q
F
A
Y
L
G
D
-
A
R
N
N
-
V
G
N
S
L
M
V
G
-
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
-
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
-
E
A
-
W
-
D
E
R
V
A
-
L
M
K
P
----
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
------------------
H
N
D
ET
T
I
G
K
Q
V
A
D
K
F
GMKGL
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
------
89
PsiBlast_CBE
74.16
35%
-96
- C9 -
3M5C
2
AOTC_XANCP
A:
[23-354]
-
L
K
H
F
L
N
T
Q
D
W
S
R
A
E
L
D
A
L
L
T
Q
A
----
A
L
F
K
---
R
N
K
---
L
-
G
---
S
E
----
L
K
G
-
K
S
I
A
L
V
F
F
N
P
S
M
R
T
R
T
S
F
E
L
G
A
F
Q
L
G
G
H
A
V
-
V
L
Q
P
G
K
DAWPIE
F
N
L
G
T
VMDGDT
E
-
E
H
I
A
E
V
A
R
V
L
G
R
Y
V
D
L
I
G
V
R
--
A
F
P
K
FVD
W
S
K
D
R
E
D
Q
V
L
K
S
F
A
K
Y
S
P
V
P
V
I
N
-
M
E
T
-
I
T
H
P
C
Q
E
L
A
H
A
L
A
L
Q
E
---
H
--
F
G
---
T
PD
L
R
G
K
K
Y
V
L
T
W
T
Y
H
P
K
-
P
L
N
T
A
V
A
N
S
A
L
T
I
-
A
T
R
M
G
M
D
V
T
L
L
C
P
T
P
D
Y
-
I
L
D
E
R
Y
M
D
W
A
A
Q
N
V
A
E
S
G
G
S
L
Q
V
S
H
D
I
D
S
A
Y
A
G
A
D
V
V
Y
A
K
S
W
G
A
L
P
F
-
F
G
-
N
--
W
-
E
-
P
E
K
-
P
I
R
D
Q
Y
QH
F
I
V
D
E
R
K
M
A
-
L
-
T
N
-
N
G
V
F
S
H
C
L
P
L
------------------
R
------------------
R
N
V
-----------------
E
A
T
D
A
V
M
D
S
P
N
C
I
A
I
D
E
A
E
N
R
L
H
V
Q
K
A
I
M
A
A
L
V
---
91
PsiBlast_CBE
74.13
35%
-94
- C9 -
3M4N
2
AOTC_XANCP
A:
[23-354]
-
L
K
H
F
L
N
T
Q
D
W
S
R
A
E
L
D
A
L
L
T
Q
A
----
A
L
F
K
---
R
N
K
---
L
-
G
---
S
E
----
L
K
G
-
K
S
I
A
L
V
F
F
N
P
S
M
R
T
R
T
S
F
E
L
G
A
F
Q
L
G
G
H
A
V
-
V
L
Q
P
G
K
DAWPIE
F
N
L
G
T
VMDGDT
E
-
E
H
I
A
E
V
A
R
V
L
G
R
Y
V
D
L
I
G
V
R
--
A
F
P
K
FVD
W
S
K
D
R
E
D
Q
V
L
K
S
F
A
K
Y
S
P
V
P
V
I
N
-
M
E
T
-
I
T
H
P
C
Q
E
L
A
H
A
L
A
L
Q
E
---
H
--
F
G
---
T
PD
L
R
G
K
K
Y
V
L
T
W
T
Y
H
P
K
-
P
L
N
T
A
V
A
N
S
A
L
T
I
-
A
T
R
M
G
M
D
V
T
L
L
C
P
T
P
D
Y
-
I
L
D
E
R
Y
M
D
W
A
A
Q
N
V
A
E
S
G
G
S
L
Q
V
S
H
D
I
D
S
A
Y
A
G
A
D
V
V
Y
A
K
S
W
G
A
L
P
F
-
F
G
-
N
--
W
-
E
-
P
E
K
-
P
I
R
D
Q
Y
QH
F
I
V
D
E
R
K
M
A
-
L
-
T
N
-
N
G
V
F
S
H
C
L
P
L
------------------
R
------------------
R
N
V
-----------------
A
A
T
D
A
V
M
D
S
P
N
C
I
A
I
D
E
A
E
N
R
L
H
V
Q
K
A
I
M
A
A
L
V
---
90
PsiBlast_CBE
73.65
35%
-95
- C9 -
3M5D
2
AOTC_XANCP
A:
[23-354]
-
L
K
H
F
L
N
T
Q
D
W
S
R
A
E
L
D
A
L
L
T
Q
A
----
A
L
F
K
---
R
N
K
---
L
-
G
---
S
E
----
L
K
G
-
K
S
I
A
L
V
F
F
N
P
S
M
R
T
R
T
S
F
E
L
G
A
F
Q
L
G
G
H
A
V
-
V
L
Q
P
G
K
DA
W
P
I
E
F
N
L
G
T
VMDGDT
E
-
E
H
I
A
E
V
A
R
V
L
G
R
Y
V
D
L
I
G
V
R
--
A
F
P
K
FVD
W
S
K
D
R
E
D
Q
V
L
K
S
F
A
K
Y
S
P
V
P
V
I
N
-
M
E
T
-
I
T
H
P
C
Q
E
L
A
H
A
L
A
L
Q
E
---
H
--
F
G
---
T
PD
L
R
G
K
K
Y
V
L
T
W
T
Y
H
P
K
-
P
L
N
T
A
V
A
N
S
A
L
T
I
-
A
T
R
M
G
M
D
V
T
L
L
C
P
T
P
D
Y
-
I
L
D
E
R
Y
M
D
W
A
A
Q
N
V
A
E
S
G
G
S
L
Q
V
S
H
D
I
D
S
A
Y
A
G
A
D
V
V
Y
A
K
S
W
G
A
L
P
F
-
F
G
-
N
--
W
-
E
-
P
E
K
-
P
I
R
D
Q
Y
QH
F
I
V
D
E
R
K
M
A
-
L
-
T
N
-
N
G
V
F
S
H
C
L
P
L
------------------
R
------------------
R
N
V
-----------------
R
A
T
D
A
V
M
D
S
P
N
C
I
A
I
D
E
A
E
N
R
L
H
V
Q
K
A
I
M
A
A
L
V
---
19
PsiBlast_PDB
72.72
37%
-94
- C9 -
1DUV
3
OTC1_ECOLI
G:
[6-333]
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
----
A
K
L
K
---
A
D
K
---
K
-
S
---
G
K
EEA
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
-
Y
L
G
P
S
G
------
S
Q
I
G
H
------
K
-
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
Y
G
Q
----------
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
-
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
---
H
LP
G
K
---
A
--
F
N
E
----
M
T
L
V
Y
A
G
D
-
A
R
N
N
-
M
G
N
S
M
L
E
A
-
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
-
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
-
A
K
-
E
K
-
W
A
E
-
R
I
A
-
L
L
R
E
----
Y
Q
V
N
S
K
M
M
Q
-
L
T
G
N
P
E
V
K
F
L
H
C
L
P
A
FHDDQTTLGKKMAEEFGL
H
------------------
G
G
M
-----------------
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
S
K
-
125
HHSearch
72.65
40%
-93
- C9 -
1DUV
3
OTC1_ECOLI
G:
[4-333]
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
----
A
K
L
K
---
A
D
K
KS-
G
K
E
---
E
A
---
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
-
Y
L
G
P
S
G
------
S
Q
I
G
H
------
K
-
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
Y
G
Q
----------
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
-
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
---
H
--
L
P
GK-
A
--
F
N
E
----
M
T
L
V
Y
A
G
D
-
A
R
N
N
-
M
G
N
S
M
L
E
A
-
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
-
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
-
A
K
-
E
K
W
A
-
E
-
R
I
A
-
L
L
R
E
----
Y
Q
V
N
S
K
M
M
Q
-
L
T
G
N
P
E
V
K
F
L
H
C
L
P
A
------------------
F
HDDQTTLGKKMAEEFGLH
G
G
M
-----------------
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
S
K
-
31
PsiBlast_CBE
72.36
37%
-92
- C9 -
1DUV
2
OTC1_ECOLI
I:
[6-333]
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
----
A
K
L
K
---
A
D
K
---
K
-
S
---
G
K
EEA
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
-
Y
L
G
P
S
G
------
S
Q
I
G
H
------
K
-
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
Y
G
Q
----------
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
-
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
---
H
LP
G
K
---
A
--
F
N
E
----
M
T
L
V
Y
A
G
D
-
A
R
N
N
-
M
G
N
S
M
L
E
A
-
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
-
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
-
A
K
-
E
K
-
W
A
E
-
R
I
A
-
L
L
R
E
----
Y
Q
V
N
S
K
M
M
Q
-
L
T
G
N
P
E
V
K
F
L
H
C
L
P
A
FHDDQTTLGKKMAEEFGL
H
------------------
G
G
M
-----------------
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
S
K
-
32
PsiBlast_CBE
72.09
37%
-94
- C9 -
1DUV
2
OTC1_ECOLI
H:
[6-333]
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
----
A
K
L
K
---
A
D
K
---
K
-
S
---
G
K
EEA
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
-
Y
L
G
P
S
G
------
S
Q
I
G
H
------
K
-
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
--
G
Y
G
Q
----------
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
-
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
---
H
LP
G
K
---
A
--
F
N
E
----
M
T
L
V
Y
A
G
D
-
A
R
N
N
-
M
G
N
S
M
L
E
A
-
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
-
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
-
A
K
-
E
K
-
W
A
E
-
R
I
A
-
L
L
R
E
----
Y
Q
V
N
S
K
M
M
Q
-
L
T
G
N
P
E
V
K
F
L
H
C
L
P
A
FHDDQTTLGKKMAEEFGL
H
------------------
G
G
M
-----------------
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
S
K
-
92
PsiBlast_CBE
63.86
34%
-100
- C9 -
3LXM
1
PYRB_YERPE
A:
[32-329]
--
K
H
I
I
S
I
N
D
L
S
R
D
E
L
E
L
V
L
R
T
A
----
A
S
L
K
---
K
T
P
---------
Q
P
---
E
L
L
K
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
I
H
R
L
G
A
S
V
V
G
F
S
D
---------------------G
E
T
L
A
D
T
M
S
V
I
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
----------
S
R
L
A
A
Q
F
S
-
G
N
V
P
I
V
N
A
G
D
G
A
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
---
T
--
Q
G
---
R
--
L
D
N
----
I
N
I
A
M
V
G
D
L
K
Y
G
R
-
T
V
H
S
L
T
Q
A
L
A
K
F
N
G
N
H
F
F
F
I
A
P
D
-
A
L
A
M
P
A
Y
I
L
Q
M
L
E
E
K
E
I
E
-----
Y
S
L
H
E
S
L
E
E
V
V
P
E
L
D
I
L
Y
---
M
T
R
--------------
Y
A
N
-
V
K
A
Q
----
F
I
L
R
S
S
D
L
T
-
G
-
A
R
D
N
L
K
V
L
H
P
L
P
--------------------------------------
R
I
D
-----------------
E
I
T
T
D
V
D
K
T
P
Y
A
Y
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
---