@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1689: (2016-05-04 )
MSGMILDELSWRGLIAQSTDLDTLAAEAQRGPMTVYAGFDPTAPSLHAGHLVPLLTLRRFQRAGHRPIVLAGGATGMIGDPRDVGERSLNEADTVAEWTERIRGQLERFVDFDDSPMGAIVENNLEWTGSLSAIEFLRDIGKHFSVNVMLARDTIRRRLAGEGISYTEFSYLLLQANDYVELHRRHGCTLQIGGADQWGNIIAGVRLVRQKLGATVHALTVPLVTAADGTKFGKSTGGGSLWLDPQMTSPYAWYQYFVNTADADVIRYLRWFTFLSADELAELEQATAQRPQQRAAQRRLASELTVLVHGEAATAAVEHASRALFGRGELARLDEATLAAALRETTVAELKPGSPDGIVDLLVASGLSASKGAARRTIHEGGVSVNNIRVDNEEWVPQSSDFLHGRWLVLRRGKRSIAGVERIG
Atome Classification :
(31 SA)
.........10........20.-...----....30........40........50........60........70........80--.-.-..-....90........100.......------110..-----------...--..------------120........130.......140.......150.......160--.--.......170.......180.......190.......200.......-----------210-.-----------------..-....------220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350........360.......370.......380.......390.......400.......410.......420..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSGMILDELSWRGLIAQST
D
L
D
-
T
L
A
----
A
EAQRG
P
M
T
V
YAGFDPTAPSLHAG
H
L
V
P
L
L
T
L
R
R
F
Q
RAGHR
P
I
V
L
AGGATGMIGD
P
--
R
-
D
-
V
G
-
E
RSLNE
A
D
T
V
A
E
W
T
E
R
I
R
G
Q
L
E
R
F
------VDFDD-----------SP
M
--
G
A
------------
I
-
V
ENNLEWTG
S
L
S
A
I
E
F
L
R
D
I
G
K
HF
S
V
N
V
M
L
A
R
D
T
I
R
R
R
LA-G--E--GISY
T
E
F
S
Y
L
L
L
QAN
D
Y
V
E
L
H
R
RHG
C
T
L
Q
IG
G
A
D
Q
W
G
N
I
I
A
G
V
R
L
V
R
-----------
Q
K
L-G-----------------A
T
-
V
H
A
L
------
T
V
P
L
V
TAADGTKFGKSTGGG
S
L
W
LDPQMTS
P
Y
A
W
Y
Q
Y
F
VNTA
D
A
D
V
I
R
Y
L
R
W
F
T
FL
S
A
D
E
L
A
E
L
E
Q
A
T
A
Q
R
P
Q
Q
R
A
A
Q
R
R
L
A
S
E
L
T
V
L
V
HGE
A
A
T
A
A
V
E
H
A
S
R
A
LFGR
G
E
L
A
R
L
D
E
A
T
L
A
A
A
L
R
E
T
T
V
A
EL-KPGSP
D
G
I
V
D
L
L
V
ASGLSASKGAAR
R
T
IHEGG
V
S
V
N
N
I
R
VDNEEWVPQSSDFLH
G
R
W
L
V
L
RRG
K
R
SIAGVERIG
1
PsiBlast_PDB
99.68
100%
-114
- C3 -
2JAN
-
SYY_MYCTU
A:
[5-423]
----
I
L
D
E
L
S
W
R
G
L
I
A
Q
S
T
D
L
D
-
T
L
A
----
A
E
A
Q
R
G
P
M
T
V
Y
A
G
F
D
P
T
A
P
S
L
H
A
G
H
L
V
P
L
L
T
L
R
R
F
Q
R
A
G
H
R
P
I
V
L
A
G
G
A
T
G
M
I
G
D
P
--
R
-
D
-
V
G
-
E
R
S
L
N
E
A
D
T
V
A
E
W
T
E
R
I
R
G
Q
L
E
R
F
------
V
D
F
D
D
-----------
S
P
M
--
G
A
------------
I
-
V
E
N
N
L
E
W
T
G
S
L
S
A
I
E
F
L
R
D
I
G
K
H
F
S
V
N
V
M
L
A
R
D
T
I
R
R
R
L
A
-
G
--
E
--
G
I
S
Y
T
E
F
S
Y
L
L
L
Q
A
N
D
Y
V
E
L
H
R
R
H
G
C
T
L
Q
I
G
G
A
D
Q
W
G
N
I
I
A
G
V
R
L
V
R
-----------
Q
K
L
-
G
-----------------
A
T
-
V
H
A
L
------
T
V
P
L
V
T
A
A
D
G
T
K
F
G
K
S
T
G
G
G
S
L
W
L
D
P
Q
M
T
S
P
Y
A
W
Y
Q
Y
F
V
N
T
A
D
A
D
V
I
R
Y
L
R
W
F
T
F
L
S
A
D
E
L
A
E
L
E
Q
A
T
A
Q
R
P
Q
Q
R
A
A
Q
R
R
L
A
S
E
L
T
V
L
V
H
G
E
A
A
T
A
A
V
E
H
A
S
R
A
L
F
G
R
G
E
L
A
R
L
D
E
A
T
L
A
A
A
L
R
E
T
T
V
A
E
L
-
K
P
G
S
P
D
G
I
V
D
L
L
V
A
S
G
L
S
A
S
K
G
A
A
R
R
T
I
H
E
G
G
V
S
V
N
N
I
R
V
D
N
E
E
W
V
P
Q
S
S
D
F
L
H
G
R
W
L
V
L
R
R
G
K
R
S
I
A
G
V
E
R
I
-
38
HHSearch
98.87
99%
-114
- C3 -
2JAN
-
SYY_MYCTU
A:
[5-423]
----
I
L
D
E
L
S
W
R
G
L
I
A
Q
S
T
D
L
D
-
T
L
A
----
A
E
A
Q
R
G
P
M
T
V
Y
A
G
F
D
P
T
A
P
S
L
H
A
G
H
L
V
P
L
L
T
L
R
R
F
Q
R
A
G
H
R
P
I
V
L
A
G
G
A
T
G
M
I
G
D
P
--
R
-
D
-
V
G
-
E
R
S
L
N
E
A
D
T
V
A
E
W
T
E
R
I
R
G
Q
L
E
R
F
------
V
D
F
D
D
-----------
S
P
M
--
G
A
------------
I
-
V
E
N
N
L
E
W
T
G
S
L
S
A
I
E
F
L
R
D
I
G
K
H
F
S
V
N
V
M
L
A
R
D
T
I
R
R
R
L
A
-
G
--
E
--
G
I
S
Y
T
E
F
S
Y
L
L
L
Q
A
N
D
Y
V
E
L
H
R
R
H
G
C
T
L
Q
I
G
G
A
D
Q
W
G
N
I
I
A
G
V
R
L
V
R
-----------
Q
K
L
-
G
-----------------
A
T
-
V
H
A
L
------
T
V
P
L
V
T
A
A
D
G
T
K
F
G
K
S
T
G
G
G
S
L
W
L
D
P
Q
M
T
S
P
Y
A
W
Y
Q
Y
F
V
N
T
A
D
A
D
V
I
R
Y
L
R
W
F
T
F
L
S
A
D
E
L
A
E
L
E
Q
A
T
A
Q
R
P
Q
Q
R
A
A
Q
R
R
L
A
S
E
L
T
V
L
V
H
G
E
A
A
T
A
A
V
E
H
A
S
R
A
L
F
G
R
G
E
L
A
R
L
D
E
A
T
L
A
A
A
L
R
E
T
T
V
A
E
L
K
P
G
S
P
-
D
G
I
V
D
L
L
V
A
S
G
L
S
A
S
K
G
A
A
R
R
T
I
H
E
G
G
V
S
V
N
N
I
R
V
D
N
E
E
W
V
P
Q
S
S
D
F
L
H
G
R
W
L
V
L
R
R
G
K
R
S
I
A
G
V
E
R
I
-
17
PsiBlast_PDB
76.32
51%
-94
- C3 -
1WQ4
1
SYY_ECOLI
A:
[2-320]
-
S
S
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
-
A
L
A
----
E
R
L
A
Q
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
F
K
-
A
A
-
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
------
L
D
F
D
C
-----------
G
E
N
--
S
A
------------
I
-
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
-
R
--
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------
R
L
H
-
Q
-----------------
N
Q
-
V
F
G
L
------
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
-----------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.99
55%
-96
- C3 -
1TYD
1
SYY_GEOSE
E:
[3-311]
----
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
-
G
L
R
----
K
L
L
N
E
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
S
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
G
K
-
K
S
-
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
------
L
D
F
E
A
-----------
D
G
N
--
P
A
------------
K
-
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
E
----
T
--
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------
K
T
K
-
G
------------------
R
-
A
F
G
L
------
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
----------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.89
49%
-94
- C3 -
3TS1
1
SYY_GEOSE
A:
[3-319]
----
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
-
G
L
R
----
K
L
L
N
E
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
G
K
-
K
S
-
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
------
L
D
F
E
A
-----------
D
G
N
--
P
A
------------
K
-
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
E
----
T
--
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------
K
T
K
-
G
------------------
R
-
A
F
G
L
------
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
74.84
52%
-97
- C3 -
1VBN
1
SYY_ECOLI
A:
[2-317]
----
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
-
A
L
A
----
E
R
L
A
Q
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
F
K
-
A
A
-
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
------
L
D
F
D
C
-----------
G
E
N
--
S
A
------------
I
-
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
-
R
--
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------
R
L
H
-
Q
-----------------
N
Q
-
V
F
G
L
------
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
-----------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.71
56%
-95
- C3 -
1TYC
-
SYY_GEOSE
A:
[3-311]
----
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
-
G
L
R
----
K
L
L
N
E
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
P
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
G
K
-
K
S
-
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
------
L
D
F
E
A
-----------
D
G
N
--
P
A
------------
K
-
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
E
----
T
--
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------
K
T
K
-
G
------------------
R
-
A
F
G
L
------
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
----------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.62
51%
-92
- C3 -
2YXN
1
SYY_ECOLI
A:
[3-321]
-
S
S
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
-
A
L
A
----
E
R
L
A
Q
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
F
K
-
A
A
-
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
------
L
D
F
D
C
-----------
G
E
N
--
S
A
------------
I
-
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
-
R
--
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------
R
L
H
-
Q
-----------------
N
Q
-
V
F
G
L
------
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
-----------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.62
55%
-95
- C3 -
1TYA
1
SYY_GEOSE
E:
[3-311]
----
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
-
G
L
R
----
K
L
L
N
E
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
A
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
G
K
-
K
S
-
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
------
L
D
F
E
A
-----------
D
G
N
--
P
A
------------
K
-
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
E
----
T
--
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------
K
T
K
-
G
------------------
R
-
A
F
G
L
------
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
----------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.55
51%
-91
- C3 -
1WQ3
1
SYY_ECOLI
A:
[3-321]
-
S
S
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
-
A
L
A
----
E
R
L
A
Q
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
F
K
-
A
A
-
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
------
L
D
F
D
C
-----------
G
E
N
--
S
A
------------
I
-
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
-
R
--
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------
R
L
H
-
Q
-----------------
N
Q
-
V
F
G
L
------
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
-----------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.55
52%
-93
- C3 -
1X8X
2
SYY_ECOLI
A:
[3-321]
-
S
S
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
-
A
L
A
----
E
R
L
A
Q
G
P
I
A
L
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
F
K
-
A
A
-
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
------
L
D
F
D
C
-----------
G
E
N
--
S
A
------------
I
-
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
-
R
--
E
DQ
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------
R
L
H
-
Q
-----------------
N
Q
-
V
F
G
L
------
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
-----------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.50
55%
-93
- C3 -
1TYB
1
SYY_GEOSE
E:
[3-311]
----
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
-
G
L
R
----
K
L
L
N
E
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
G
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
G
K
-
K
S
-
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
------
L
D
F
E
A
-----------
D
G
N
--
P
A
------------
K
-
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
E
----
T
--
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------
K
T
K
-
G
------------------
R
-
A
F
G
L
------
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
----------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.39
55%
-95
- C3 -
4TS1
1
SYY_GEOSE
A:
[3-311]
----
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
-
G
L
R
----
K
L
L
N
E
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
G
K
-
K
S
-
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
------
L
D
F
E
A
-----------
D
G
N
--
P
A
------------
K
-
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
E
----
T
--
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------
K
T
K
-
G
------------------
R
-
A
F
G
L
------
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
----------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
74.35
55%
-95
- C3 -
4TS1
1
SYY_GEOSE
B:
[3-311]
----
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
-
G
L
R
----
K
L
L
N
E
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
G
K
-
K
S
-
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
------
L
D
F
E
A
-----------
D
G
N
--
P
A
------------
K
-
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
E
----
T
--
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------
K
T
K
-
G
------------------
R
-
A
F
G
L
------
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
----------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
74.29
52%
-97
- C3 -
1VBN
1
SYY_ECOLI
B:
[2-317]
----
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
-
A
L
A
----
E
R
L
A
Q
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
F
K
-
A
A
-
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
------
L
D
F
D
C
-----------
G
E
N
--
S
A
------------
I
-
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
-
R
--
E
DQ
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------
R
L
H
-
Q
-----------------
N
Q
-
V
F
G
L
------
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
-----------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.23
49%
-93
- C3 -
2TS1
-
SYY_GEOSE
A:
[3-319]
----
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
-
G
L
R
----
K
L
L
N
E
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
G
K
-
K
S
-
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
------
L
D
F
E
A
-----------
D
G
N
--
P
A
------------
K
-
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
E
----
T
--
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------
K
T
K
-
G
------------------
R
-
A
F
G
L
------
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.05
43%
-91
- C3 -
1JIL
1
SYY_STAAE
A:
[2-324]
-
T
N
V
L
I
E
D
L
K
W
R
G
L
I
Y
Q
Q
T
D
E
Q
-
G
I
E
----
D
L
L
N
K
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
--
S
-
G
-
K
S
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
H
N
I
------
F
E
F
-
G
-----------
T
D
H
--
G
A
------------
V
-
L
V
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
E
----
H
--
G
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
-----------
R
M
Y
-
G
-----------------
Q
T
D
A
Y
G
L
------
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
S
E
-
S
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
S
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
E
Q
S
K
N
E
A
P
H
L
R
E
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
Q
A
L
F
----------------------------------------------------------------------------------------------------
45
HHSearch
73.82
52%
-92
- C3 -
2YXN
1
SYY_ECOLI
A:
[3-322]
-
S
S
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
-
A
L
A
----
E
R
L
A
Q
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
-
F
K
A
A
-
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
------
L
D
F
D
-------------
C
G
EN
S
A
------------
I
-
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
-
R
ED
Q
--
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------
R
L
H
-
Q
-----------------
N
Q
-
V
F
G
L
------
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
T
E
-
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
----------------------------------------------------------------------------------------------------------
40
HHSearch
73.32
49%
-93
* C3 *
2TS1
-
SYY_GEOSE
A:
[2-319]
---
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
-
G
L
R
----
K
L
L
N
E
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
-
G
K
K
S
-
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
------
L
D
F
E
A
-----------
D
G
N
--
P
A
------------
K
-
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
E
----
T
--
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------
K
T
K
-
G
------------------
R
-
A
F
G
L
------
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
T
E
-
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
E
Q
E
L
R
E
A
P
E
K
R
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
73.24
52%
-97
- C3 -
1VBM
3
SYY_ECOLI
B:
[2-317]
----
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
-
A
L
A
----
E
R
L
A
Q
G
P
I
A
L
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
F
K
-
A
A
-
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
------
L
D
F
D
C
-----------
G
E
N
--
S
A
------------
I
-
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
-
R
--
E
DQ
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------
R
L
H
-
Q
-----------------
N
Q
-
V
F
G
L
------
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
-----------------------------------------------------------------------------------------------------------
41
HHSearch
73.07
43%
-91
- C3 -
1JIL
1
SYY_STAAE
A:
[2-324]
-
T
N
V
L
I
E
D
L
K
W
R
G
L
I
Y
Q
Q
T
D
E
Q
-
G
I
E
----
D
L
L
N
K
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
--
S
-
G
K
S
E
-
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
H
N
I
------
F
E
F
G
------------
T
D
H
--
G
A
------------
V
-
L
V
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
E
----
H
--
G
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
-----------
R
M
Y
G
Q
-----------------
T
D
-
A
Y
G
L
------
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
S
E
-
S
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
S
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
E
Q
S
K
N
E
A
P
H
L
R
E
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
Q
A
L
F
----------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.61
43%
-88
- C3 -
1JIK
1
SYY_STAAE
A:
[2-320]
-
T
N
V
L
I
E
D
L
K
W
R
G
L
I
Y
Q
Q
T
D
E
Q
-
G
I
E
----
D
L
L
N
K
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
--
S
-
G
-
K
S
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
H
N
I
------
F
E
F
-
G
-----------
T
D
H
--
G
A
------------
V
-
L
V
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
E
----
H
--
G
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
-----------
R
M
Y
-
G
-----------------
Q
T
D
A
Y
G
L
------
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
S
E
-
S
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
S
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
E
Q
S
K
N
E
A
P
H
L
R
E
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.51
52%
-94
- C3 -
1VBM
3
SYY_ECOLI
A:
[2-317]
----
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
-
A
L
A
----
E
R
L
A
Q
G
P
I
A
L
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
--
S
F
K
-
A
A
-
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
------
L
D
F
D
C
-----------
G
E
N
--
S
A
------------
I
-
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
-
R
--
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------
R
L
H
-
Q
-----------------
N
Q
-
V
F
G
L
------
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
E
E
E
D
K
N
S
G
K
A
P
R
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
-----------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
72.07
43%
-94
- C3 -
1JIJ
1
SYY_STAAE
A:
[2-320]
-
T
N
V
L
I
E
D
L
K
W
R
G
L
I
Y
Q
Q
T
D
E
Q
-
G
I
E
----
D
L
L
N
K
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
--
S
-
G
-
K
S
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
H
N
I
------
F
E
F
-
G
-----------
T
D
H
--
G
A
------------
V
-
L
V
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
E
----
H
--
G
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
-----------
R
M
Y
-
G
-----------------
Q
T
D
A
Y
G
L
------
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
S
E
-
S
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
S
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
E
Q
S
K
N
E
A
P
H
L
R
E
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.02
43%
-90
- C3 -
1JII
1
SYY_STAAE
A:
[2-320]
-
T
N
V
L
I
E
D
L
K
W
R
G
L
I
Y
Q
Q
T
D
E
Q
-
G
I
E
----
D
L
L
N
K
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
--
S
-
G
-
K
S
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
H
N
I
------
F
E
F
-
G
-----------
T
D
H
--
G
A
------------
V
-
L
V
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
E
----
H
--
G
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
-----------
R
M
Y
-
G
-----------------
Q
T
D
A
Y
G
L
------
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
S
E
-
S
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
S
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
E
Q
S
K
N
E
A
P
H
L
R
E
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
--------------------------------------------------------------------------------------------------------
43
HHSearch
66.85
34%
-86
- C3 -
1Y42
1
SYYM_NEUCR
X:
[34-388]
--
Q
N
T
W
D
L
F
E
E
R
G
Y
V
K
D
T
A
G
T
K
E
H
I
A
----
E
L
M
R
T
R
R
I
G
A
Y
V
G
I
D
P
T
A
P
S
L
H
V
G
H
L
L
P
L
M
P
L
F
W
M
Y
L
E
G
Y
K
A
F
T
L
I
G
G
S
T
A
K
I
G
D
P
--
T
-
G
------------
D
A
T
M
N
M
T
K
I
H
Y
Q
L
K
K
L
------
W
E
N
V
D
TQMRARGYEAD
W
A
R
--
K
R
------------
G
-
I
V
N
N
N
H
W
W
N
K
Q
P
M
L
E
V
L
R
R
V
G
H
A
L
R
I
G
P
M
L
S
R
D
T
V
K
N
K
M
T
-
Q
G-
D
--
G
V
S
F
A
E
F
T
Y
P
I
M
Q
G
W
D
W
F
E
L
F
Y
Q
Q
G
V
Q
M
Q
I
G
G
S
D
Q
Y
G
N
I
I
S
G
L
E
V
V
K
-----------
A
A
R
-
E
SEPDPQERKYVTPKTAL
D
E
-
C
V
G
F
------
T
V
P
L
L
T
D
S
S
G
A
K
F
G
K
S
A
-
G
N
A
I
W
L
D
P
Y
Q
T
S
V
F
D
F
Y
G
Y
F
V
R
R
S
D
Q
E
V
E
N
L
L
K
L
F
T
F
M
P
I
S
E
I
T
K
T
M
E
E
H
I
K
D
P
S
K
R
V
A
Q
H
T
L
A
R
E
V
V
T
L
V
H
G
K
Q
E
A
S
A
A
E
D
Q
H
R
M
M
Y
T
G
--------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
64.61
40%
-93
- C3 -
2PID
1
SYYM_HUMAN
B:
[46-346]
------------------------------------
P
Q
T
I
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
--
S
-
G
R
T
K
-
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
N
H
Q
Q
L
F
T
D
G
-----------
R
S
W
--
G
S
------------
F
T
V
L
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
K
-
S
P-
E
--
G
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
-----------
K
L
T
-
G
-----------------
E
D
-
V
F
G
I
------
T
V
P
L
I
T
--------------
A
V
W
L
N
R
D
K
T
S
P
F
E
L
Y
Q
F
F
V
R
Q
P
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
M
Q
L
H
V
K
E
P
E
R
R
G
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
-----------------------------------------------------------------------------------------------------
44
HHSearch
64.46
39%
-87
- C3 -
2PID
1
SYYM_HUMAN
A:
[10-346]
---
G
L
L
A
A
Q
K
A
R
G
L
F
K
D
F
F
P
E
T
-
G
T
K
IELP
E
L
F
---
P
Q
T
I
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
--
S
-
G
R
T
K
-
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
-------
A
A
N
H
Q
Q
LFTDGR---
S
W
G
--
S
F
------------
T
-
V
L
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
K
-
S
P-
E
--
G
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
-----------
K
L
T
-
G
-----------------
E
D
-
V
F
G
I
------
T
V
P
L
I
T
--------------
A
V
W
L
N
R
D
K
T
S
P
F
E
L
Y
Q
F
F
V
R
Q
P
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
M
Q
L
H
V
K
E
P
E
R
R
G
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
-----------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.89
40%
-91
- C3 -
2PID
1
SYYM_HUMAN
A:
[46-346]
------------------------------------
P
Q
T
I
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
--
S
-
G
R
T
K
-
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
N
H
Q
Q
L
F
T
D
G
-----------
R
S
W
--
G
S
------------
F
T
V
L
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
K
-
S
P-
E
--
G
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
-----------
K
L
T
-
G
-----------------
E
D
-
V
F
G
I
------
T
V
P
L
I
T
--------------
A
V
W
L
N
R
D
K
T
S
P
F
E
L
Y
Q
F
F
V
R
Q
P
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
M
Q
L
H
V
K
E
P
E
R
R
G
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
-----------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
60.55
36%
-85
- C3 -
4OJM
1
SYYM_NEUCR
X:
[68-386]
----------------------------------------
Y
V
G
I
D
P
T
A
P
S
L
H
V
G
H
L
L
P
L
M
P
L
F
W
M
Y
L
E
G
Y
K
A
F
T
L
I
G
G
S
T
A
K
I
G
D
P
TG-----------
S
S
S
D
A
T
M
N
M
T
-
K
I
H
Y
Q
L
K
K
L
------
W
E
N
V
D
-----------
T
Q
M
--
R
A
RGYEADWARKRG
I
-
V
N
N
N
-
H
W
W
N
K
Q
P
M
L
E
V
L
R
R
V
G
H
A
L
R
I
G
P
M
L
S
R
D
T
V
K
N
K
M
T
Q
G
--
D
--
G
V
S
F
A
E
F
T
Y
P
I
M
Q
G
W
D
W
F
E
L
F
Y
Q
Q
G
V
Q
M
Q
I
G
G
S
D
Q
Y
G
N
I
I
S
G
L
E
V
V
K
AARESEPDPQE
R
K
Y
-
V
-----------------
T
P
-
K
T
A
L
DECVGF
T
V
P
L
L
T
D
S
S
G
A
K
F
G
K
S
-
A
G
N
A
I
W
L
D
P
Y
Q
T
S
V
F
D
F
Y
G
Y
F
V
R
R
S
D
Q
E
V
E
N
L
L
K
L
F
T
F
M
P
I
S
E
I
T
K
T
M
E
E
H
I
K
D
P
S
K
R
V
A
Q
H
T
L
A
R
E
V
V
T
L
V
H
G
K
Q
E
A
S
A
A
E
D
Q
H
R
M
M
Y
----------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
60.45
36%
-86
- C3 -
1Y42
1
SYYM_NEUCR
X:
[68-386]
----------------------------------------
Y
V
G
I
D
P
T
A
P
S
L
H
V
G
H
L
L
P
L
M
P
L
F
W
M
Y
L
E
G
Y
K
A
F
T
L
I
G
G
S
T
A
K
I
G
D
P
TG--------------
D
A
T
M
N
M
T
-
K
I
H
Y
Q
L
K
K
L
------
W
E
N
V
D
-----------
T
Q
M
--
R
A
RGYEADWARKRG
I
-
V
N
N
N
-
H
W
W
N
K
Q
P
M
L
E
V
L
R
R
V
G
H
A
L
R
I
G
P
M
L
S
R
D
T
V
K
N
K
M
T
Q
G
--
D
--
G
V
S
F
A
E
F
T
Y
P
I
M
Q
G
W
D
W
F
E
L
F
Y
Q
Q
G
V
Q
M
Q
I
G
G
S
D
Q
Y
G
N
I
I
S
G
L
E
V
V
K
AARESEPDPQE
R
K
Y
-
V
-----------------
T
P
-
K
T
A
L
DECVGF
T
V
P
L
L
T
D
S
S
G
A
K
F
G
K
S
-
A
G
N
A
I
W
L
D
P
Y
Q
T
S
V
F
D
F
Y
G
Y
F
V
R
R
S
D
Q
E
V
E
N
L
L
K
L
F
T
F
M
P
I
S
E
I
T
K
T
M
E
E
H
I
K
D
P
S
K
R
V
A
Q
H
T
L
A
R
E
V
V
T
L
V
H
G
K
Q
E
A
S
A
A
E
D
Q
H
R
M
M
Y
----------------------------------------------------------------------------------------------------